Product Name

  • Name

    1,4-Dihydroxynaphthalene

  • EINECS 209-336-4
  • CAS No. 571-60-8
  • Article Data140
  • CAS DataBase
  • Density 1.33 g/cm3
  • Solubility slightly soluble in Water
  • Melting Point 191-192 °C (dec.)
  • Formula C10H8 O2
  • Boiling Point 391 °C at 760 mmHg
  • Molecular Weight 162.188
  • Flash Point 202.5 °C
  • Transport Information
  • Appearance almost white Solid
  • Safety 26-39-45-36/37/39-28A-24
  • Risk Codes R25;R36/37/38;R43   
  • Molecular Structure Molecular Structure of 571-60-8 (1,4-Dihydroxynaphthalene)
  • Hazard Symbols
  • Synonyms 1,4-Dihydroxynaphthalene;1,4-Naphthohydroquinone; 1,4-Naphthoquinol; Hydronaphthoquinone;Naphthohydroquinone; a-Naphthoquinhydrone
  • PSA 40.46000
  • LogP 2.25100

Synthetic route

[1,4]naphthoquinone
130-15-4

[1,4]naphthoquinone

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

Conditions
ConditionsYield
With acetic acid; zinc Ambient temperature; sonication, less than 5 min;100%
With hydrogen; palladium 10% on activated carbon under 2585.81 Torr; for 6h;100%
With sodium dithionite In diethyl ether; water at 20℃; for 1h;100%
3-mercaptopropionic acid ethyl ester
5466-06-8

3-mercaptopropionic acid ethyl ester

[1,4]naphthoquinone
130-15-4

[1,4]naphthoquinone

A

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

B

2-[2-(ethoxycarbonyl)ethyl]thio-1,4-naphthoquinone
234112-67-5

2-[2-(ethoxycarbonyl)ethyl]thio-1,4-naphthoquinone

Conditions
ConditionsYield
In ethanol at 20℃; Substitution;A n/a
B 93%
1,4-diacetoxynaphthalene
5697-00-7

1,4-diacetoxynaphthalene

A

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

B

1-acetoxy-4-hydroxynaphthalene
70662-30-5

1-acetoxy-4-hydroxynaphthalene

Conditions
ConditionsYield
With lipase of Pseudomonas sp; water In various solvent(s) at 25℃; for 2.5h; Hydrolysis; deacetylation;A n/a
B 89%
1-methoxy-1,3-butadiene
10034-09-0

1-methoxy-1,3-butadiene

p-benzoquinone
106-51-4

p-benzoquinone

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

Conditions
ConditionsYield
With [O=P(2-py)3W(CO)(NO)2](BF4)2 In water at 20℃; for 1.5h; Diels-Alder reaction;85%
butyraldehyde
123-72-8

butyraldehyde

[1,4]naphthoquinone
130-15-4

[1,4]naphthoquinone

A

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

B

1-(1,4-dihydroxynaphthalen-2-yl)butan-1-one
72827-02-2

1-(1,4-dihydroxynaphthalen-2-yl)butan-1-one

Conditions
ConditionsYield
In acetone Irradiation; Inert atmosphere; Flow reactor; Green chemistry;A 7 %Spectr.
B 83%
With 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide for 16h; Friedel Crafts acylation; Irradiation; Inert atmosphere; chemoselective reaction;A n/a
B 40%
In acetone; iso-butanol for 14.5h; Friedel-Crafts Acylation; Irradiation; Green chemistry;
Hepta<2.2.2>starphen-5,6,11,12,17,18-hexaol
96722-19-9

Hepta<2.2.2>starphen-5,6,11,12,17,18-hexaol

A

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

B

Hepta<2.2.2>starphen-5,18:6,11:12,17-trichinon
6880-74-6

Hepta<2.2.2>starphen-5,18:6,11:12,17-trichinon

C

5,12,17,18-Tetrahydroxyhepta<2.2.2>starphen-6,11-chinon
96722-21-3

5,12,17,18-Tetrahydroxyhepta<2.2.2>starphen-6,11-chinon

Conditions
ConditionsYield
With [1,4]naphthoquinone In acetic acid at 100℃; for 0.0833333h; Yield given;A n/a
B n/a
C 80%
With [1,4]naphthoquinone In acetic acid at 100℃; for 0.0833333h; Yields of byproduct given;A n/a
B n/a
C 80%
2-formylthiophenol
29199-11-9

2-formylthiophenol

[1,4]naphthoquinone
130-15-4

[1,4]naphthoquinone

A

12-hydroxy-12H-benzo[b]thioxanthene-6,11-dione

12-hydroxy-12H-benzo[b]thioxanthene-6,11-dione

B

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

Conditions
ConditionsYield
In ethanol at 20℃; for 4h;A 65%
B n/a
3,4-dihydronaphthalene-1(2H)-one
529-34-0

3,4-dihydronaphthalene-1(2H)-one

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

Conditions
ConditionsYield
With iodosylbenzene; racemic (salen)Mn(III) In acetonitrile at 0℃; for 3h;63%
3-mercaptopropionic acid
107-96-0

3-mercaptopropionic acid

[1,4]naphthoquinone
130-15-4

[1,4]naphthoquinone

A

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

B

3-[(1,4-dioxo-1,4-dihydronaphthalene-2-yl)thio]propionic acid
65726-66-1

3-[(1,4-dioxo-1,4-dihydronaphthalene-2-yl)thio]propionic acid

Conditions
ConditionsYield
Stage #1: 3-mercaptopropionic acid; [1,4]naphthoquinone In ethanol at 20℃; for 24h;
Stage #2: With lead dioxide In chloroform at 20℃; for 4h;
A n/a
B 52%
[(R)-1-(3,4-Dimethoxy-phenyl)-ethyl]-(4-methoxy-naphthalen-1-yl)-amine
293307-92-3

[(R)-1-(3,4-Dimethoxy-phenyl)-ethyl]-(4-methoxy-naphthalen-1-yl)-amine

A

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

B

1-(R)-(3,4-dimethoxyphenyl)ethylamine
100570-24-9

1-(R)-(3,4-dimethoxyphenyl)ethylamine

Conditions
ConditionsYield
Stage #1: [(R)-1-(3,4-Dimethoxy-phenyl)-ethyl]-(4-methoxy-naphthalen-1-yl)-amine With ammonium cerium(IV) nitrate In water; acetonitrile Oxidation; C-N bond cleavage;
Stage #2: With sodium tetrahydroborate In water; acetonitrile Reduction;
A n/a
B 47%
quinoclamine
2797-51-5

quinoclamine

[1,4]naphthoquinone
130-15-4

[1,4]naphthoquinone

A

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

B

N-(naphthoquinonyl)-N-(3-chloro-1,4-naphthoquinonyl)amine

N-(naphthoquinonyl)-N-(3-chloro-1,4-naphthoquinonyl)amine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 12h; pH=12;A n/a
B 41%
3,4-dihydro-2H-pyran
110-87-2

3,4-dihydro-2H-pyran

[1,4]naphthoquinone
130-15-4

[1,4]naphthoquinone

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

Conditions
ConditionsYield
With oxygen; toluene-4-sulfonic acid In 1,2-dichloro-ethane at 83℃; under 760.051 Torr; Diels-Alder Cycloaddition; Reflux;41%
(3-methyl-2-butenyl)trifluorosilane
114067-34-4

(3-methyl-2-butenyl)trifluorosilane

[1,4]naphthoquinone
130-15-4

[1,4]naphthoquinone

A

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

B

deoxylapachol
3568-90-9

deoxylapachol

C

2,2-di-(3-methyl-but-2-enyl)-2,3-dihydro-1,4-naphthoquinone
82214-84-4

2,2-di-(3-methyl-but-2-enyl)-2,3-dihydro-1,4-naphthoquinone

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran at -20℃; for 1h;A 38%
B 28%
C 32%
[1,4]naphthoquinone
130-15-4

[1,4]naphthoquinone

A

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

B

deoxylapachol
3568-90-9

deoxylapachol

C

2,2-di-(3-methyl-but-2-enyl)-2,3-dihydro-1,4-naphthoquinone
82214-84-4

2,2-di-(3-methyl-but-2-enyl)-2,3-dihydro-1,4-naphthoquinone

Conditions
ConditionsYield
With (3-methyl-2-butenyl)trifluorosilane; tetrabutyl ammonium fluoride In tetrahydrofuran at -20℃; for 1h;A 38%
B 28%
C 32%
Dodecanal
112-54-9

Dodecanal

[1,4]naphthoquinone
130-15-4

[1,4]naphthoquinone

A

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

B

1-(1,4-dihydroxynaphthalen-2-yl)-dodecan-1-one
875243-46-2

1-(1,4-dihydroxynaphthalen-2-yl)-dodecan-1-one

Conditions
ConditionsYield
In acetone Irradiation; Inert atmosphere; Flow reactor; Green chemistry;A 7 %Spectr.
B 32%
With 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide for 16h; Friedel Crafts acylation; Irradiation; Inert atmosphere; chemoselective reaction;
ethylaluminum dichloride
563-43-9

ethylaluminum dichloride

[1,4]naphthoquinone
130-15-4

[1,4]naphthoquinone

A

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

B

4-ethoxy-1-naphthol
27294-38-8

4-ethoxy-1-naphthol

Conditions
ConditionsYield
In toluene at -78℃; for 2h;A 26%
B 44 % Spectr.
[1,4]naphthoquinone
130-15-4

[1,4]naphthoquinone

A

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

B

4-ethoxy-1-naphthol
27294-38-8

4-ethoxy-1-naphthol

Conditions
ConditionsYield
With ethylaluminum dichloride In toluene at -78℃; for 2h;A 26%
B 44 % Spectr.
[1,4]naphthoquinone
130-15-4

[1,4]naphthoquinone

A

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

B

2-chloro-1,4-dihydroxynaphthalene
73661-09-3

2-chloro-1,4-dihydroxynaphthalene

Conditions
ConditionsYield
With (Z)-3-methyl-2-butenyltrichlorosilane In formamide for 24h; Ambient temperature;A 23%
B 18%
2-vinylthiophene
1918-82-7

2-vinylthiophene

[1,4]naphthoquinone
130-15-4

[1,4]naphthoquinone

A

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

B

4,5,6,11-tetrahydro-6,11-dioxoanthra<2,1-b>thiophene
80090-37-5

4,5,6,11-tetrahydro-6,11-dioxoanthra<2,1-b>thiophene

Conditions
ConditionsYield
In toluene for 48h; Heating;A n/a
B 22%
naphthalene
91-20-3

naphthalene

A

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

B

α-naphthol
90-15-3

α-naphthol

Conditions
ConditionsYield
With peroxygenase; dihydrogen peroxide In acetonitrile at 20℃; for 0.416667h; pH=3; pH-value; Enzymatic reaction;A 15.4%
B 6.7%
2-vinyl-4-methylthiophene
84548-65-2

2-vinyl-4-methylthiophene

[1,4]naphthoquinone
130-15-4

[1,4]naphthoquinone

A

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

B

6,11-dihydro-1-methyl-6,11-dioxoanthra<2,1-b>thiophene
84548-67-4

6,11-dihydro-1-methyl-6,11-dioxoanthra<2,1-b>thiophene

C

4,5,6,11-tetrahydro-1-methyl-6,11-dioxoanthra<2,1-b>thiophene
84641-98-5

4,5,6,11-tetrahydro-1-methyl-6,11-dioxoanthra<2,1-b>thiophene

Conditions
ConditionsYield
In toluene for 48h; Heating;A n/a
B 10%
C 5%
α-naphthol
90-15-3

α-naphthol

A

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

B

[1,4]naphthoquinone
130-15-4

[1,4]naphthoquinone

Conditions
ConditionsYield
((2-O-C6H4CN)2CH2C(CH3)2)Cu for 12h;A 4.8%
B 6.9%
1,4-dioxane
123-91-1

1,4-dioxane

1,1-Bisethylene
7478-69-5

1,1-Bisethylene

[1,4]naphthoquinone
130-15-4

[1,4]naphthoquinone

A

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

B

2-[2,2-bis-(4-dimethylamino-phenyl)-vinyl]-[1,4]naphthoquinone

2-[2,2-bis-(4-dimethylamino-phenyl)-vinyl]-[1,4]naphthoquinone

Conditions
ConditionsYield
at 70℃; unter Lichtausschluss;
α-naphthol
90-15-3

α-naphthol

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

Conditions
ConditionsYield
With sodium hydroxide; dipotassium peroxodisulfate
With sodium hydroxide; ammonium peroxydisulfate
With CYP175A1; dihydrogen peroxide In aq. phosphate buffer at 50℃; for 1h; pH=7.5; Kinetics; Enzymatic reaction;
α-naphthol
90-15-3

α-naphthol

A

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

B

1,2-Dihydroxynaphthalene
574-00-5

1,2-Dihydroxynaphthalene

Conditions
ConditionsYield
With sodium metabisulfite; sodium hydroxide; ozone weiteres Reagens: Sauerstoff;
2-diazo-1,2-naphthoquinone
879-15-2

2-diazo-1,2-naphthoquinone

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

Conditions
ConditionsYield
With sulfuric acid
4-amino-1-naphthalenesufonic acid
84-86-6

4-amino-1-naphthalenesufonic acid

furan-2,3,5(4H)-trione pyridine (1:1)

furan-2,3,5(4H)-trione pyridine (1:1)

A

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

B

α-naphthol
90-15-3

α-naphthol

C

1-hydroxy-4-naphthalenesulfonate
84-87-7

1-hydroxy-4-naphthalenesulfonate

Conditions
ConditionsYield
at 220 - 300℃; im Autoklaven;
4-amino-1-naphthalenesufonic acid
84-86-6

4-amino-1-naphthalenesufonic acid

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

Conditions
ConditionsYield
With sodium hydroxide at 220 - 300℃; unter Druck;
1,4-diacetoxynaphthalene
5697-00-7

1,4-diacetoxynaphthalene

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

Conditions
ConditionsYield
With sodium hydroxide; ethanol Kochen des Reaktionsgemisches mit konz. wss. HCl und SnCl2;
Multi-step reaction with 5 steps
1: sodium tetrahydroborate / methanol
2: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere
3: sodium hydroxide / ethanol / 3 h / 0 °C
4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / N,N-dimethyl-formamide / 0.33 h / 120 °C / Microwave irradiation; Inert atmosphere
5: dihydrogen peroxide
View Scheme
hydroxynaphthylamine
607-30-7

hydroxynaphthylamine

A

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

B

4-amino-1-naphthol
2834-90-4

4-amino-1-naphthol

Conditions
ConditionsYield
With ethanol; sulfuric acid
1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

[1,4]naphthoquinone
130-15-4

[1,4]naphthoquinone

Conditions
ConditionsYield
With 2,2'-bipyridylchromium peroxide In benzene for 0.5h; Heating;100%
With dihydrogen peroxide; bis-(tributyltin oxide) dioxochromium(VI) In benzene at 50℃; for 1.5h;100%
With 2,2'-bipyridylchromium peroxide In benzene for 0.5h; Product distribution; Heating; effect of various chromium(VI) based oxidants;100%
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

2-((thiophen-2-yl)ethylamino)naphthalene-1,4-dione

2-((thiophen-2-yl)ethylamino)naphthalene-1,4-dione

Conditions
ConditionsYield
With cerium(III) chloride heptahydrate; triethylamine In ethanol at 20℃; Further stages;100%
1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

benzoyl chloride
98-88-4

benzoyl chloride

1,4-dibenzoyloxy naphthalene
7437-73-2

1,4-dibenzoyloxy naphthalene

Conditions
ConditionsYield
In dichloromethane at 35℃; Flow reactor;99%
With pyridine at 0 - 20℃; for 16h; Reflux;86%
1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

methacryloyl anhydride
760-93-0

methacryloyl anhydride

1,4-dimethacryloyloxynaphthalene

1,4-dimethacryloyloxynaphthalene

Conditions
ConditionsYield
With dmap In dichloromethane at 35℃; Flow reactor;99%
1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

dimethyl sulfate
77-78-1

dimethyl sulfate

1,4-dimethoxynaphthalene
10075-62-4

1,4-dimethoxynaphthalene

Conditions
ConditionsYield
With potassium hydroxide In tetrahydrofuran; water Flow reactor;97%
With barium dihydroxide; hydrogen; palladium on activated charcoal In N,N-dimethyl-formamide92%
With potassium carbonate In acetone for 1h; Reflux;89%
1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

ethanol
64-17-5

ethanol

4-ethoxy-1-naphthol
27294-38-8

4-ethoxy-1-naphthol

Conditions
ConditionsYield
With hydrogenchloride for 0.25h;97%
1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

benzene
71-43-2

benzene

2-phenyl[1,4]naphthoquinone
2348-77-8

2-phenyl[1,4]naphthoquinone

Conditions
ConditionsYield
With palladium(II) acetylacetonate; dimethyl sulfoxide; silver carbonate; Trimethylacetic acid at 140℃; for 24h; Catalytic behavior; Reagent/catalyst; Sealed tube;97%
1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

diethylene glycol
111-46-6

diethylene glycol

4-(1,4,7-Trioxaheptyl)-1-naphthol
135664-65-2

4-(1,4,7-Trioxaheptyl)-1-naphthol

Conditions
ConditionsYield
With hydrogenchloride96%
1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

1-thiopropane
107-03-9

1-thiopropane

1,4-bis(1-propylthio)naphthalene

1,4-bis(1-propylthio)naphthalene

Conditions
ConditionsYield
With toluene-4-sulfonic acid In benzene for 1h; Heating;96%
1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

ethane-1,2-dithiol
540-63-6

ethane-1,2-dithiol

1,4-bis(2-mercapto-1-ethylthio)naphthalene

1,4-bis(2-mercapto-1-ethylthio)naphthalene

Conditions
ConditionsYield
With toluene-4-sulfonic acid In benzene for 1h; Heating;96%
1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

acetyl chloride
75-36-5

acetyl chloride

1,4-diacetoxynaphthalene
5697-00-7

1,4-diacetoxynaphthalene

Conditions
ConditionsYield
With dmap; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 3h; Inert atmosphere;96%
methanol
67-56-1

methanol

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

A

4-methoxynaphth-1-ol
84-85-5

4-methoxynaphth-1-ol

B

1,4-dimethoxynaphthalene
10075-62-4

1,4-dimethoxynaphthalene

Conditions
ConditionsYield
With hydrogenchloride for 0.25h; Mechanism;A 95%
B 2%
With hydrogenchloride for 0.25h;A 95%
B 2%
With boron trifluoride
propan-1-ol
71-23-8

propan-1-ol

1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

4-Propoxy-[1]naphthol
85-13-2

4-Propoxy-[1]naphthol

Conditions
ConditionsYield
With hydrogenchloride for 0.25h;95%
With hydrogenchloride
1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

isopropyl alcohol
67-63-0

isopropyl alcohol

4-isopropyloxynaphth-1-ol
41426-37-3

4-isopropyloxynaphth-1-ol

Conditions
ConditionsYield
With hydrogenchloride for 0.25h;95%
With boron trifluoride at 80℃;
With hydrogenchloride
1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

1,3-diphenyl-benzo[c]thiophene-5,6-dicarbaldehyde
64218-57-1

1,3-diphenyl-benzo[c]thiophene-5,6-dicarbaldehyde

1,3-Diphenylnaphthaceno<2,3-c>thiophene-6,11-quinone
84165-86-6

1,3-Diphenylnaphthaceno<2,3-c>thiophene-6,11-quinone

Conditions
ConditionsYield
With toluene-4-sulfonic acid In chloroform for 4h; Heating;95%
1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

2-chloro-ethanol
107-07-3

2-chloro-ethanol

4-(2-chloroethoxy)-1-naphthol
73661-04-8

4-(2-chloroethoxy)-1-naphthol

Conditions
ConditionsYield
With hydrogenchloride for 0.25h;95%
With hydrogenchloride94%
With hydrogenchloride at 20℃; for 7h; Inert atmosphere;91%
1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

N-Boc-1,3-diaminopropane
75178-96-0

N-Boc-1,3-diaminopropane

tert-butyl 3-(4-hydroxynaphth-1-ylamino)propylcarbamate
1191288-43-3

tert-butyl 3-(4-hydroxynaphth-1-ylamino)propylcarbamate

Conditions
ConditionsYield
In toluene at 120℃; for 1h;95%
1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

acetic anhydride
108-24-7

acetic anhydride

1,4-diacetoxynaphthalene
5697-00-7

1,4-diacetoxynaphthalene

Conditions
ConditionsYield
With pyridine at 20℃; for 1h;94%
With pyridine at 20℃; for 5h;83%
In pyridine at 20℃; for 1h;54%
With zinc(II) chloride
With sodium acetate
1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

2-methyl-propan-1-ol
78-83-1

2-methyl-propan-1-ol

4-Isobutoxy-1-naphthol
73661-02-6

4-Isobutoxy-1-naphthol

Conditions
ConditionsYield
With hydrogenchloride for 0.25h;94%
1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

5-chloro-2-methyl-4-nitroaniline
13852-51-2

5-chloro-2-methyl-4-nitroaniline

2-chloro-5-methyl-1,4-phenylenediamine
5307-03-9

2-chloro-5-methyl-1,4-phenylenediamine

Conditions
ConditionsYield
With sodium hydroxide In water; toluene94%
1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

butan-1-ol
71-36-3

butan-1-ol

4-Butoxy-[1]naphthol
73661-01-5

4-Butoxy-[1]naphthol

Conditions
ConditionsYield
With hydrogenchloride for 0.25h;93%
With hydrogenchloride
1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

4-sec-Butoxy-1-naphthol
73661-03-7

4-sec-Butoxy-1-naphthol

Conditions
ConditionsYield
With hydrogenchloride for 0.25h;93%
1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

2-methoxy-ethanol
109-86-4

2-methoxy-ethanol

4-(2-Methoxyethoxy)-1-naphthol
70524-63-9

4-(2-Methoxyethoxy)-1-naphthol

Conditions
ConditionsYield
With hydrogenchloride for 0.25h;92%
1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

2,2'-[1,2-ethanediylbis(oxy)]bisethanol
112-27-6

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

4-(1,4,7,10-Tetraoxadecyl)-1-naphthol
135664-66-3

4-(1,4,7,10-Tetraoxadecyl)-1-naphthol

Conditions
ConditionsYield
With hydrogenchloride92%
1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

bis[(2-pyridyl)methyl]amine
1539-42-0

bis[(2-pyridyl)methyl]amine

2-(bis(pyridin-2-ylmethyl)amino)naphthalene-1,4-dione

2-(bis(pyridin-2-ylmethyl)amino)naphthalene-1,4-dione

Conditions
ConditionsYield
With cerium(III) chloride heptahydrate; triethylamine In ethanol at 20℃; for 4h;92%
With cerium(III) chloride heptahydrate; triethylamine In ethanol at 20℃; for 6h;92%
1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

2-chloroethyl tosylate
80-41-1

2-chloroethyl tosylate

1,4-bis(2-chloroethoxy)naphthalene

1,4-bis(2-chloroethoxy)naphthalene

Conditions
ConditionsYield
With potassium hydroxide In tetrahydrofuran; water for 4h; Reflux;90%
1,4-Dihydroxynaphthalene
571-60-8

1,4-Dihydroxynaphthalene

trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

naphthalene-1,4-diyl bis(trifluoromethanesulfonate)
152873-78-4

naphthalene-1,4-diyl bis(trifluoromethanesulfonate)

Conditions
ConditionsYield
In dichloromethane Flow reactor;89%
With pyridine at 20℃; for 2h; Cooling with ice;72.6%
With pyridine 1.) 0 deg C, 5 min, 2.) 0 deg C to r.t., 24 h; Yield given;

1,4-Dihydroxynaphthalene Chemical Properties

Chemical Name: 1,4-Dihydroxynaphthalene
IUPAC NAME: Naphthalene-1,4-diol
CAS No.: 571-60-8
EINECS: 209-336-4
RTECS: QJ4730000
RTECS Class: Agricultural Chemical and Pesticide; Mutagen
Molecular Formula: C10H8O2
Molecular Weight: 160.17 g/mol
Melting Point: 191-192 °C (dec.)
Density: 1.33 g/cm3 
Flash Point: 202.5 °C
Boiling Point: 391 °C at 760 mmHg 
Following is the structure 1,4-Naphthalenediol (571-60-8):


Product Categories about 1,4-Naphthalenediol (571-60-8)are Intermediates of Dyes and Pigments;Naphthalene derivatives
The chemical synonymous of 1,4-Naphthalenediol (571-60-8) are Alpha-naphthohydroquinone;1,4-Dihydroxynaphthalene;1,4-Ndo;1,4-Naphthalenediol;1,4-Naphthohydroquinone;1,4-Napthalenediol;P-Naphthohydroquinone;Naphthalene-1,4-DIOL

1,4-Dihydroxynaphthalene Toxicity Data With Reference

1.    

orl-rat LDLo:100 mg/kg

    NCNSA6    National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. 5 (1953),35.

1,4-Dihydroxynaphthalene Consensus Reports

Reported in EPA TSCA Inventory.

1,4-Dihydroxynaphthalene Safety Profile

Poison by ingestion. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes:
T: Toxic
Xn: Harmful
Risk Statements about 1,4-Naphthalenediol (571-60-8):
R24/25 Toxic in contact with skin and if swallowed. 
R26 Very toxic by inhalation. 
R36/37/38 Irritating to eyes, respiratory system and skin. 
R41 Risk of serious damage to eyes. 
R43 May cause sensitization by skin contact. 
R50 Very toxic to aquatic organisms. 
Safety Statements about 1,4-Naphthalenediol (571-60-8):
S24 Avoid contact with skin. 
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S28A After contact with skin, wash immediately with plenty of water. 
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection. 
S38 In case of insufficient ventilation, wear suitable respiratory equipment. 
S45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). 
S61 Avoid release to the environment. Refer to special instructions/safety data sheets. 
Attentions:
1. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
2. Handling: Avoid ingestion and inhalation. Avoid contact with eyes, skin, and clothing. Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Keep container tightly closed. Wash clothing before reuse.

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