1,6-Dichlorohexane supplier

Name
1,6-Dichlorohexane
EINECS 218-491-7
CAS No. 2163-00-0
Article Data45
CAS DataBase
Density 1.031 g/cm³
Solubility Sparingly soluble in water
Melting Point -13 °C
Formula C₆H₁₂Cl₂
Boiling Point 204 °C at 760 mmHg
Molecular Weight 155.067
Flash Point 73.9 °C
Transport Information UN 3082 9/PG 3
Appearance Clear colourless liquid
Safety 26-36-61-37/39
Risk Codes 36/37/38-53
Molecular Structure
Hazard Symbols Xi
Synonyms NSC 60700;
PSA 0.00000
LogP 3.02440

Synthetic route

: 629-11-8
1,6-hexanediol

: 2163-00-0
1,6-dichlorohexane

Conditions

Conditions	Yield
Stage #1: 1,6-hexanediol With N,N-dimethylthiourea In dichloromethane at 20℃; Stage #2: With N-chloro-succinimide In dichloromethane at 20℃; for 1h; Irradiation;	98%
With hydrogenchloride; ammonium chloride In water at 50 - 110℃; for 3h; Reagent/catalyst;	96%
With thionyl chloride; Triphenylphosphine oxide at 20 - 80℃; for 3h;	87%

: 2916-20-3
1,6-bis-chlorocarbonyloxy-hexane

: 2163-00-0
1,6-dichlorohexane

Conditions

Conditions	Yield
With hexabutylguanidinium chloride at 120℃; for 4h;	93%

: 19432-96-3
3-(phenylsulfonyl)propyl chloride

A: 540-54-5
1-Chloropropane

B: 17637-57-9
(cyclopropylsulfonyl)benzene

C: 2163-00-0
1,6-dichlorohexane

Conditions

Conditions	Yield
With sodium amalgam In benzene for 6h; Heating;	A 17% B 53% C 13%

...Expand

: 629-11-8
1,6-hexanediol

A: 2009-83-8
6-chloro-1-hexanol

B: 2163-00-0
1,6-dichlorohexane

Conditions

Conditions	Yield
With tetrachloromethane; triphenylphosphine In acetonitrile Product distribution; Mechanism;	A 48% B 39%
With hydrogenchloride at 92 - 96℃;
With hydrogenchloride

: 124-09-4
1,6-Hexanediamine

: 2163-00-0
1,6-dichlorohexane

Conditions

Conditions	Yield
With nitrosylchloride

: 5326-21-6
N,N'-dibenzoylhexane-1,6-diamine

A: 100-47-0
benzonitrile

B: 2163-00-0
1,6-dichlorohexane

Conditions

Conditions	Yield
With phosphorus pentachloride Destillieren der erhaeltlichen Verbindung;

: 75-44-5
phosgene

: 822-06-0
Hexamethylene diisocyanate

: 2163-00-0
1,6-dichlorohexane

: 544-10-5
1-Chlorohexane

A: 54305-90-7
1,5-dichloro-hexane

B: 56375-88-3
1,3-dichlorohexane

C: 50635-35-3, 140238-71-7, 140238-72-8
1,4-dichlorohexane

D: 2163-00-0
1,6-dichlorohexane

Conditions

Conditions	Yield
With chlorine Further byproducts given;
With sulfuryl dichloride; dibenzoyl peroxide at 90℃; Further byproducts given;
With sulfuryl dichloride; dibenzoyl peroxide Further byproducts given;

...Expand

: 544-10-5
1-Chlorohexane

A: 54305-90-7
1,5-dichloro-hexane

B: 2162-92-7
1,2-dichlorohexane

C: 56375-88-3
1,3-dichlorohexane

D: 50635-35-3, 140238-71-7, 140238-72-8
1,4-dichlorohexane

E: 62017-16-7
1,1-dichloro-n-hexane

F: 2163-00-0
1,6-dichlorohexane

Conditions

Conditions	Yield
With N-chloropiperidine; 2,2'-azobis(isobutyronitrile) In trifluoroacetic acid at 30℃; Product distribution; Rate constant; Irradiation; relative rate constants, position selectivity, substrate selectivity;
With chlorine In benzene at -10.1℃; Product distribution; dependence of the selectivity of chlorination on the conc. of benzene;
With N-chloropiperidine; 2,2'-azobis(isobutyronitrile) In trifluoroacetic acid at 30℃; for 3h; Product distribution; Rate constant; Irradiation; other objects - relative reactivities and relative rate constants for the various positions of chlorination;

...Expand

: 6222-17-9
1,6-diacetoxyhexane

A: 40200-18-8
6-chloro-1-hexyl acetate

B: 2163-00-0
1,6-dichlorohexane

Conditions

Conditions	Yield
With aluminium trichloride at 154℃; for 1h; Product distribution; Mechanism; var. temp.;	A 29 % Chromat. B 4 % Chromat.

: 3653-39-2
N-benzoyl-1H-hexahydroazepine

: 10026-13-8, 874483-75-7
phosphorus pentachloride

: 2163-00-0
1,6-dichlorohexane

Conditions

Conditions	Yield
folgend Destillieren;

hexanediol-(1.6)-diphenyl ether: hexanediol-(1.6)-diphenyl ether

: 2163-00-0
1,6-dichlorohexane

Conditions

Conditions	Yield
With hydrogenchloride at 165 - 175℃;

N-benzoyl-hexamethyleneimine: N-benzoyl-hexamethyleneimine

: 2163-00-0
1,6-dichlorohexane

Conditions

Conditions	Yield
With phosphorus pentachloride

: 124-09-4
1,6-Hexanediamine

: 60-29-7
diethyl ether

nitrosyl chloride: nitrosyl chloride

A: 54305-90-7
1,5-dichloro-hexane

B: 2163-00-0
1,6-dichlorohexane

C unsaturated chloro compounds C6H11Cl: unsaturated chloro compounds C6H11Cl

...Expand

: 7647-01-0
hydrogenchloride

: 629-11-8
1,6-hexanediol

CuCl: CuCl

A: 2009-83-8
6-chloro-1-hexanol

B: 2163-00-0
1,6-dichlorohexane

Conditions

Conditions	Yield
unter kontinuierlicher Extraktion mit Toluol;

...Expand

: 7647-01-0
hydrogenchloride

: 629-11-8
1,6-hexanediol

A: 2009-83-8
6-chloro-1-hexanol

B: 91692-23-8
1,13-dichloro-7-oxatridecane

C: 108291-44-7
13-chloro-7-oxatridecane-1-ol

D: 2163-00-0
1,6-dichlorohexane

Conditions

Conditions	Yield
at 92 - 96℃; weitere Produkte: 6.6'-Dihydroxy-dihexylaether und Hexamethylenglykol-bis-<6-hydroxy-hexyl>-aether;

...Expand

: 7647-01-0
hydrogenchloride

: 10125-18-5
1,6-diphenoxyhexane

: 2163-00-0
1,6-dichlorohexane

Conditions

Conditions	Yield
at 165 - 175℃; im geschlossenen Rohr;

: C7H12ClFO2

A: 373-29-5
1,6-difluorohexane

B: 1550-09-0
1-chloro-6-fluorohexane

C: 2163-00-0
1,6-dichlorohexane

Conditions

Conditions	Yield
With HBGF at 120℃; for 1.5h; Title compound not separated from byproducts;	A n/a B 57 % Spectr. C n/a

...Expand

: 505-48-6
octane-1,8-dioic acid

: 2163-00-0
1,6-dichlorohexane

Conditions

Conditions	Yield
With lead(IV) acetate; ammonium chloride at 20℃; for 4h; mechanical activation;	0.92 mmol
With lead(IV) acetate; ammonium chloride at 20℃; for 6h; mechanical activation;	0.94 mmol

: 505-48-6
octane-1,8-dioic acid

A: 821-57-8
7-chloroheptanoic acid

B: 2163-00-0
1,6-dichlorohexane

Conditions

Conditions	Yield
With lead(IV) acetate; ammonium chloride at 20℃; for 48h;	A 0.13 mmol B 0.60 mmol
With lead(IV) acetate; ammonium chloride at 20℃; for 96h;	A 0.11 mmol B 0.44 mmol

: 629-11-8
1,6-hexanediol

A: bis(6-chlorohexyl) ether

B: 2163-00-0
1,6-dichlorohexane

Conditions

Conditions	Yield
With hydrogenchloride; 1-methylimidazolium chloride at 80 - 135℃; Conversion of starting material;

: 35487-17-3
1-methylimidazolium chloride

: 2163-00-0
1,6-dichlorohexane

Conditions

Conditions	Yield
With hydrogenchloride

: 1013-90-7
(c-C6H11)2SbLi

: 2163-00-0
1,6-dichlorohexane

: 1060-74-8
{(c-C6H11)2Sb}2(CH2)6

Conditions

Conditions	Yield
In tetrahydrofuran; diethyl ether drop by drop addn. of 1,6-dichlorohexane in THF over 30 min to a (c-C6H11)2SbLi soln. in ether at -45°C; mixt. treated with aq. NH4Cl, evapn. of the ether;	98.9%
In tetrahydrofuran; diethyl ether drop by drop addn. of 1,6-dichlorohexane in THF over 30 min to a (c-C6H11)2SbLi soln. in ether at -45°C; mixt. treated with aq. NH4Cl, evapn. of the ether;	98.9%

: 78430-91-8
1-(4-vinylbenzyl)-1H-imidazole

: 2163-00-0
1,6-dichlorohexane

: 3,3'-(hexane-1,6-diyl)bis(1-(4-vinylbenzyl)-1H-imidazol-3-ium) chloride

Conditions

Conditions	Yield
In acetonitrile at 80℃; for 12h; Inert atmosphere; Schlenk technique;	98%

: 616-47-7
1-methyl-1H-imidazole

: 2163-00-0
1,6-dichlorohexane

: 1,6-bis(3-methylimidazolium-1-yl)hexane dichloride

Conditions

Conditions	Yield
With calcium chloride In acetonitrile for 48h; Reflux;	97%
In acetonitrile at 20℃; for 24h; Reflux;	87%
at 70 - 100℃; for 0.025h; Microwave irradiation;	82%

: 141-53-7
sodium formate

: 2163-00-0
1,6-dichlorohexane

: 61836-77-9
hexane-1,6-diyl diformate

Conditions

Conditions	Yield
tetrabutylammomium bromide at 115℃; for 1.5h;	96%

: 14814-09-6
3-Mercaptopropyltriethoxysilane

: 2163-00-0
1,6-dichlorohexane

A: 1-chloro-6-thiopropyltriethoxysilylhexane

B: 1,6-bis(thiopropyltriethoxysilyl) hexane

Conditions

Conditions	Yield
Stage #1: 3-Mercaptopropyltriethoxysilane With sodium ethanolate In ethanol at 20℃; for 3h; Reflux; Stage #2: 1,6-dichlorohexane In ethanol at 80℃; for 3.5h; Reflux;	A 95% B 5%

...Expand

: 17754-90-4
4-(Diethylamino)salicylaldehyde

: 2163-00-0
1,6-dichlorohexane

: C17H26ClNO2

Conditions

Conditions	Yield
With tetrabutylammomium bromide; sodium hydroxide for 6h; Reflux;	93.4%

: 2163-00-0
1,6-dichlorohexane

: hexamethylene-1,6-bis(thiosulfate)disodium salt

Conditions

Conditions	Yield
With sodium hydroxide; sodium thiosulfate In water for 9h; pH=7.1 - 7.3; Product distribution / selectivity; Heating / reflux;	93.3%
With sodium hydroxide; sodium thiosulfate In water for 9h; pH=7.2 - 10.0; Product distribution / selectivity; Heating / reflux;	93.3%
With sodium hydroxide; sodium thiosulfate In water for 9h; pH=4.9 - 5.1; Product distribution / selectivity; Heating / reflux;	91.4%

: 25364-47-0
1-(2,6-diisopropylphenyl)-1H-imidazole

: 2163-00-0
1,6-dichlorohexane

: 1,1'-di(2,6-diisopropropylphenyl)-3,3'-(1,6-hexanediyl)diimidazolium dichloride

Conditions

Conditions	Yield
at 140℃; for 24h;	93%
at 140℃; for 6h; neat (no solvent);	72%

: 2163-00-0
1,6-dichlorohexane

: 115662-09-4
8-hydroxy-1,1,7,7-tetramethyl-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline-9-carbaldehyde

: C23H34ClNO2

Conditions

Conditions	Yield
With tetrabutylammomium bromide; sodium hydroxide for 6h; Reflux;	93%
With 18-crown-6 ether; potassium carbonate In N,N-dimethyl-formamide Reflux;	90%
With potassium carbonate In N,N-dimethyl-formamide for 12h; Reflux; Inert atmosphere;	83%

: 6674-22-2
1,8-diazabicyclo[5.4.0]undec-7-ene

: 2163-00-0
1,6-dichlorohexane

: 1,1'-(hexane-1,6-diyl)bis(1,8-diazabicyclo[5.4.0]undec-7-enium) dichlorine

Conditions

Conditions	Yield
In cyclohexane for 8h; Reflux; Inert atmosphere;	93%

: 120-72-9
indole

: 2163-00-0
1,6-dichlorohexane

: 95133-96-3
1,1'-hexane-1,6-diylbis(1H-indole)

Conditions

Conditions	Yield
Stage #1: indole With sodium hydroxide In dimethyl sulfoxide Stage #2: 1,6-dichlorohexane In dimethyl sulfoxide at 20℃; for 3h; Further stages.;	92%

: 2163-00-0
1,6-dichlorohexane

: 69506-88-3
1,1'-(1,6-hexanediyl)bisimidazole

: 2Br(1-)*C18H30N4(2+)

Conditions

Conditions	Yield
In toluene for 24h; Reflux;	92%

: 55310-46-8
sodium dibenzyldithiocarbamate

: 2163-00-0
1,6-dichlorohexane

: 1,6-bis(N, N-dibenzylcarbamothioyl)hexane

Conditions

Conditions	Yield
With potassium iodide for 4h; Reagent/catalyst; Reflux;	91.8%

: 55310-46-8
sodium dibenzyldithiocarbamate

: 2163-00-0
1,6-dichlorohexane

: 1,6-bis(N,N-dibenzylthiocarbamoyl disulfide)hexane

Conditions

Conditions	Yield
Stage #1: 1,6-dichlorohexane With sodium hydroxide; sodium thiosulfate In water for 9h; pH=7.1 - 7.3; Heating / reflux; Stage #2: sodium dibenzyldithiocarbamate With formaldehyd; sodium hydrogencarbonate In water; toluene at 22 - 23℃; for 23h; Product distribution / selectivity;	91%

: 55310-46-8
sodium dibenzyldithiocarbamate

: sodium thiosulfate

: 2163-00-0
1,6-dichlorohexane

: 1,6-bis(N,N-dibenzylthiocarbamoyl disulfide)hexane

Conditions

Conditions	Yield
Stage #1: sodium thiosulfate; 1,6-dichlorohexane With sodium hydroxide In water for 9h; pH=7.2; Heating / reflux; Stage #2: sodium dibenzyldithiocarbamate With formaldehyd; sodium hydrogencarbonate In water; toluene at 20 - 23℃; for 23h; pH=~ 8.3 - ~ 10.7; Product distribution / selectivity;	91%

...Expand

: 4376-01-6
sodium diphenylphosphide

: 2163-00-0
1,6-dichlorohexane

: 100649-32-9
(6-chlorohexyl)diphenylphosphane

Conditions

Conditions	Yield
In tetrahydrofuran; toluene at -40℃; 5 hour's addition;	90.6%

: 621-72-7
2-benzylbenzimidazole

: 2163-00-0
1,6-dichlorohexane

: 1039358-79-6
C20H23ClN2

Conditions

Conditions	Yield
With sodium hydroxide Heating;	90%

: 6637-29-2
2-(phenoxymethyl)-1H-benzimidazole

: 2163-00-0
1,6-dichlorohexane

: 1039358-72-9
C20H23ClN2O

Conditions

Conditions	Yield
With sodium hydroxide Heating;	90%

: 14814-09-6
3-Mercaptopropyltriethoxysilane

: 2163-00-0
1,6-dichlorohexane

: 1-chloro-6-thiopropyltriethoxysilylhexane

Conditions

Conditions	Yield
Stage #1: 3-Mercaptopropyltriethoxysilane With sodium ethanolate In ethanol at 20℃; for 3h; Reflux; Stage #2: 1,6-dichlorohexane In ethanol at 80℃; for 3.5h; Reflux;	89%
Stage #1: 3-Mercaptopropyltriethoxysilane With sodium ethanolate In ethanol at 20℃; for 3h; Reflux; Stage #2: 1,6-dichlorohexane In ethanol at 80℃; for 3.5h; Reflux;	89%
Stage #1: 3-Mercaptopropyltriethoxysilane With sodium ethanolate In ethanol at 80℃; for 3h; Stage #2: 1,6-dichlorohexane In ethanol at 80℃; for 5h;

: 14814-09-6
3-Mercaptopropyltriethoxysilane

: 2163-00-0
1,6-dichlorohexane

: 1,6-bis(thiopropyltriethoxysilyl) hexane

Conditions

Conditions	Yield
Stage #1: 3-Mercaptopropyltriethoxysilane With sodium ethanolate In ethanol at 35℃; for 2h; Reflux; Stage #2: 1,6-dichlorohexane In ethanol at 80℃; for 4.5h; Reflux;	88%
Stage #1: 3-Mercaptopropyltriethoxysilane With ethanol; sodium ethanolate for 2h; Reflux; Stage #2: 1,6-dichlorohexane at 80℃; for 4.5h; Reflux;	88%

: 868-84-8
S,S-dimethyl dithiocarbonate

: 2163-00-0
1,6-dichlorohexane

: 98429-85-7
6-chloro-1-methylsulfanylhexane

Conditions

Conditions	Yield
With tetrabutylammomium bromide; potassium hydroxide In water for 0.5h; Reflux;	87%

: 4316-42-1
1-Butylimidazole

: 2163-00-0
1,6-dichlorohexane

: 1,6-bis(3-butylimidazolium-1-yl)hexane dichloride

Conditions

Conditions	Yield
In isopropyl alcohol for 16h; Reflux;	87%

: 67-51-6
3,5-dimethyl-1H-pyrazole

: 2163-00-0
1,6-dichlorohexane

: 135585-65-8
1,1'-(hexane-1,6-diyl)-bis(3,5-dimethyl-1H-pyrazole)

Conditions

Conditions	Yield
Stage #1: 3,5-dimethyl-1H-pyrazole With potassium hydroxide In dimethyl sulfoxide at 20 - 22℃; for 0.333333h; Stage #2: 1,6-dichlorohexane In dimethyl sulfoxide at 20 - 30℃;	84%

: 2163-00-0
1,6-dichlorohexane

: 108-95-2
phenol

: 71933-93-2
1-chloro-6-phenoxyhexane

Conditions

Conditions	Yield
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate for 16h; Heating;	82%

: 280-57-9
1,4-diaza-bicyclo[2.2.2]octane

: 2163-00-0
1,6-dichlorohexane

: C18H36N4(2+)*2Cl(1-)

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 24h;	82%

: 2163-00-0
1,6-dichlorohexane

: C12H27ClN(1+)*Cl(1-)

Conditions

Conditions	Yield
With nickel; triethylamine at 100℃; for 12h; Autoclave; Inert atmosphere;	82%

: 1739-84-0
1,2-dimethyl-1H-imidazole

: 2163-00-0
1,6-dichlorohexane

: 1,6-bis(2,3-dimethylimidazolium-1-yl)hexane dichloride

Conditions

Conditions	Yield
In isopropyl alcohol for 16h; Reflux;	81%

1,6-Dichlorohexane Chemical Properties

Molecular Structure of Hexane,1,6-dichloro- (CAS NO.2163-00-0):

IUPAC Name: 1,6-dichlorohexane
Empirical Formula: C₆H₁₂Cl₂
Molecular Weight: 155.0655
H bond acceptors: 0
H bond donors: 0
Freely Rotating Bonds: 5
Polar Surface Area: 0 Å²
Index of Refraction: 1.438
Molar Refractivity: 39.54 cm³
Molar Volume: 150.3 cm³
Surface Tension: 28.6 dyne/cm
Density: 1.031 g/cm³
Flash Point: 73.9 °C
Enthalpy of Vaporization: 42.22 kJ/mol
Boiling Point: 204 °C at 760 mmHg
Vapour Pressure: 0.385 mmHg at 25°C
Melting point: -13 °C
Water Solubility: sparingly soluble
BRN: 773673
InChI
InChI=1/C6H12Cl2/c7-5-3-1-2-4-6-8/h1-6H2
Smiles
C(CCCCl)CCCl
EINECS: 218-491-7
Product Categories: Industrial/Fine Chemicals; alpha,omega-Bifunctional Alkanes; alpha,omega-Dichloroalkanes; Monofunctional & alpha,omega-Bifunctional Alkanes

1,6-Dichlorohexane Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38-53
R36/37/38:Irritating to eyes, respiratory system and skin.
R53:May cause long-term adverse effects in the aquatic environment.
Safety Statements: 26-36-61-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
S37/39:Wear suitable gloves and eye/face protection.
RIDADR: UN 3082 9/PG 3
WGK Germany: 1
HazardClass: 9
PackingGroup: III
HS Code: 29031980

1,6-Dichlorohexane Specification

Hexane,1,6-dichloro- , with CAS number of 2163-00-0, can be called 1,6-Dichlorohexane . Hexane,1,6-dichloro- (CAS NO.2163-00-0) is a clear colourless liquid, being incompatible with strong oxidizing and reducing agents. Also incompatible with many amines, nitrides, azo/diazo compounds, alkali metals and epoxides. When involved in fire it will irritating vapors and toxic gases, such as hydrogen chloride and carbon monoxide, even exposure can cause irritation of eyes, nose and throat. It is an important chemical raw material, can be used in organic synthesis.

Product Name

1,6-Dichlorohexane

Synthetic route

1,6-Dichlorohexane Chemical Properties

1,6-Dichlorohexane Safety Profile

1,6-Dichlorohexane Specification

Related Products

Hot Products