Product Name

  • Name

    1-Adamantanamine hydrochloride

  • EINECS 211-560-2
  • CAS No. 665-66-7
  • Article Data22
  • CAS DataBase
  • Density 1.067g/cm3
  • Solubility Soluble in water
  • Melting Point >300 °C(lit.)
  • Formula C10H18ClN
  • Boiling Point 1-Adamantanamine hydrochloride
  • Molecular Weight 187.713
  • Flash Point 96 °C
  • Transport Information
  • Appearance Crystalline solid
  • Safety 22-36/37-36
  • Risk Codes 22-40-20/21/22
  • Molecular Structure Molecular Structure of 665-66-7 (1-Adamantanamine hydrochloride)
  • Hazard Symbols IrritantXi
  • Synonyms 1-Adamantanamine HCl;1-Adamantanamine,hydrochloride (8CI);Adamantanamine hydrochloride (6CI);Tricyclo[3.3.1.13,7]decan-1-amine, hydrochloride (9CI);1-Adamantaminehydrochloride;Adamantylamine hydrochloride;Adamin;Adamine;Amazolon;Aminoadamantane hydrochloride;EXP 105-1;Mantadan;Mantadine;Midantane;Symmetrel;Virasol;Virofral;Tricyclo[3.3.1.13,7]decan-1-amine,hydrochloride (1:1);
  • PSA 26.02000
  • LogP 3.41620

Synthetic route

1-Adamantanamine
768-94-5

1-Adamantanamine

amantadine hydrochloride
665-66-7

amantadine hydrochloride

Conditions
ConditionsYield
With hydroxylamine hydrochloride In ethanol for 2h; Reflux;100%
With hydrogenchloride In water; toluene at 0 - 20℃; for 1h; Product distribution / selectivity;
With hydrogenchloride In diethyl ether
1-Azidoadamantane
24886-73-5

1-Azidoadamantane

amantadine hydrochloride
665-66-7

amantadine hydrochloride

Conditions
ConditionsYield
With propan-1-ol; 2,2'-azobis(isobutyronitrile); phenylsilane; bis(tri-n-butyltin)oxide In benzene Reduction; Heating;99%
2,2,2-trichloroethyl (adamantan-1-yl)carbamate
17341-91-2

2,2,2-trichloroethyl (adamantan-1-yl)carbamate

amantadine hydrochloride
665-66-7

amantadine hydrochloride

Conditions
ConditionsYield
Stage #1: 2,2,2-trichloroethyl 1-adamantylcarbamate With acetic acid; zinc
Stage #2: With acetyl chloride In methanol Heating;		99%
N-(1-adamantyl)acetamide
880-52-4

N-(1-adamantyl)acetamide

amantadine hydrochloride
665-66-7

amantadine hydrochloride

Conditions
ConditionsYield
Stage #1: N-(1-adamantyl)acetamide With sodium heptadecanoic acid; β‐cyclodextrin; sodium hydroxide In ethanol; water for 20h; Reflux;
Stage #2: With hydrogenchloride In water at 70℃;		96.5%
Stage #1: N-(1-adamantyl)acetamide With propylene glycol; potassium hydroxide In water at 125 - 130℃; for 8h; Green chemistry;
Stage #2: With hydrogenchloride In dichloromethane; water at 55 - 60℃; for 1h; Temperature; Time; Green chemistry;		82%
Stage #1: N-(1-adamantyl)acetamide With methanol; water; sodium hydroxide at 145℃; for 8h; Autoclave;
Stage #2: With hydrogenchloride In dichloromethane; water at 50℃; for 0.5h; Autoclave;		82.2%
N-(1-adamantyl)formamide
3405-48-9

N-(1-adamantyl)formamide

amantadine hydrochloride
665-66-7

amantadine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water at 85 - 90℃; for 1h;93%
1-nitroadamantane
7575-82-8

1-nitroadamantane

amantadine hydrochloride
665-66-7

amantadine hydrochloride

Conditions
ConditionsYield
Stage #1: 1-nitroadamantane With iron(III) chloride hexahydrate; hydrazine hydrate In diethyl ether; ethanol at 40℃; Inert atmosphere;
Stage #2: With hydrogenchloride In water at 70℃; for 0.5h;		89.5%
Stage #1: 1-nitroadamantane With C36H56Cl3CrN2O; magnesium; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In tetrahydrofuran at 60℃; for 24h; Inert atmosphere; Schlenk technique;
Stage #2: With hydrogenchloride In tetrahydrofuran; water; ethyl acetate at 20℃;		83%
adamantylmagnesium bromide
57680-77-0

adamantylmagnesium bromide

amantadine hydrochloride
665-66-7

amantadine hydrochloride

Conditions
ConditionsYield
Stage #1: adamantylmagnesium bromide With N,N,N,N,N,N-hexamethylphosphoric triamide; copper(I) cyanide*lithium chloride; 4,4'-bis(4-trifluoromethyl)benzophenone O-methylsulfonyloxime In tetrahydrofuran at 0℃; for 1h; Substitution;
Stage #2: With hydrogenchloride In water; acetone at 25℃; for 0.5h; Hydrolysis;		82%
Multi-step reaction with 2 steps
1: chlorobenzene; diethyl ether / 0.5 h / 0 °C
2: 334 mg / aq. HCl / ethanol / 10 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: CuCN*2LiCl / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.5 h / 0 °C
2: aq. HCl
View Scheme
1-Adamantyl bromide
768-90-1

1-Adamantyl bromide

amantadine hydrochloride
665-66-7

amantadine hydrochloride

Conditions
ConditionsYield
Stage #1: 1-Adamantyl bromide With urea at 180 - 240℃;
Stage #2: With hydrogenchloride In water Temperature;		49.7%
1-(Chloroamino)adamantane
24375-06-2

1-(Chloroamino)adamantane

A

N,N-dichloro-adamantan-1-amine
24375-05-1

N,N-dichloro-adamantan-1-amine

B

amantadine hydrochloride
665-66-7

amantadine hydrochloride

Conditions
ConditionsYield
silica gel In methanol; dichloromethane disproportionation; Yields of byproduct given;
Adamantan-1-yl-[bis-(4-trifluoromethyl-phenyl)-methylene]-amine

Adamantan-1-yl-[bis-(4-trifluoromethyl-phenyl)-methylene]-amine

amantadine hydrochloride
665-66-7

amantadine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride Yield given;
adamantan-1-yl-(4,4,5,5-tetramethyl-[1,3]dioxolan-2-ylidene)-amine

adamantan-1-yl-(4,4,5,5-tetramethyl-[1,3]dioxolan-2-ylidene)-amine

amantadine hydrochloride
665-66-7

amantadine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 10h; Heating;334 mg
adamantane
281-23-2

adamantane

amantadine hydrochloride
665-66-7

amantadine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: nitric acid / 0.5 h / 25 - 30 °C
2: acetic acid / 0.5 h / 125 °C
3: acetic acid; nitric acid / water / 125 °C
4: sodium hydroxide / water
5: hydrogenchloride / diethyl ether
View Scheme
Multi-step reaction with 2 steps
1.1: Nitrogen dioxide; ozone / 0.5 h / -78 - 30 °C
2.1: iron(III) chloride hexahydrate; hydrazine hydrate / ethanol; diethyl ether / 40 °C / Inert atmosphere
2.2: 0.5 h / 70 °C
View Scheme
1-nitroxyadamantane
32314-61-7

1-nitroxyadamantane

amantadine hydrochloride
665-66-7

amantadine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetic acid / 0.5 h / 125 °C
2: acetic acid; nitric acid / water / 125 °C
3: sodium hydroxide / water
4: hydrogenchloride / diethyl ether
View Scheme
1-(carbamoylamino)adamantne
13072-69-0

1-(carbamoylamino)adamantne

amantadine hydrochloride
665-66-7

amantadine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic acid; nitric acid / water / 125 °C
2: sodium hydroxide / water
3: hydrogenchloride / diethyl ether
View Scheme
With hydrogenchloride; pyrographite In water at 70℃; for 1h; pH=3 - 4; Industrial scale;6.4 kg
adamantan-1-amine hydronitrate

adamantan-1-amine hydronitrate

amantadine hydrochloride
665-66-7

amantadine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / water
2: hydrogenchloride / diethyl ether
View Scheme
1-acetyladamantane
1660-04-4

1-acetyladamantane

amantadine hydrochloride
665-66-7

amantadine hydrochloride

Conditions
ConditionsYield
Stage #1: 1-acetyladamantane With tetrabutylammomium bromide; sodium hydroxide In water; ethylene glycol at 40 - 190℃; for 12h; Autoclave;
Stage #2: With hydrogenchloride In water; ethylene glycol pH=4;
adamantane
281-23-2

adamantane

A

amantadine hydrochloride
665-66-7

amantadine hydrochloride

B

adamantan-2-amine hydrochloride
10523-68-9

adamantan-2-amine hydrochloride

Conditions
ConditionsYield
Stage #1: adamantane With methanol; cerium(III) chloride; di-tert-butyl-diazodicarboxylate; tetrabutyl-ammonium chloride In acetonitrile at 20℃; for 10h; Irradiation; Inert atmosphere; Sealed tube;
Stage #2: With trifluoroacetic acid In dichloromethane at 20℃; for 1h; Reagent/catalyst; Further stages;
Trimethyl orthoacetate
1445-45-0

Trimethyl orthoacetate

amantadine hydrochloride
665-66-7

amantadine hydrochloride

N-(1-adamantyl)acetamide
880-52-4

N-(1-adamantyl)acetamide

Conditions
ConditionsYield
In methanol at 135℃; for 0.25h; Microwave irradiation;100%
2,3,4-trifluorophenyl isocyanate
190774-58-4

2,3,4-trifluorophenyl isocyanate

amantadine hydrochloride
665-66-7

amantadine hydrochloride

1-(adamantan-1-yl)-3-(2,3,4-trifluorophenyl)urea
1338780-86-1

1-(adamantan-1-yl)-3-(2,3,4-trifluorophenyl)urea

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; Inert atmosphere;100%
2,2'-dithiodibenzoic acid dichloride
19602-82-5

2,2'-dithiodibenzoic acid dichloride

amantadine hydrochloride
665-66-7

amantadine hydrochloride

N,N'-bis(1-adamantyl)-2,2'-dithiodibenzamide
847431-86-1

N,N'-bis(1-adamantyl)-2,2'-dithiodibenzamide

Conditions
ConditionsYield
With triethylamine In dichloromethane for 5.5h;98%
With triethylamine In dichloromethane at -15℃; for 0.25h;
poly(ethylene glycol)-carboxylic acid, carboxyl content 6.88E-5 mol/g, Mw = 33300, PDI = 1.1

poly(ethylene glycol)-carboxylic acid, carboxyl content 6.88E-5 mol/g, Mw = 33300, PDI = 1.1

amantadine hydrochloride
665-66-7

amantadine hydrochloride

alpha cyclodextrin
10016-20-3

alpha cyclodextrin

poly(ethylene glycol) 3500, bis[N-(1-adamantyl)aminocarbonyl]-terminated, inclusion complex with α-cyclodextrin, prepared with 1-adamantylamine and proton sponge

poly(ethylene glycol) 3500, bis[N-(1-adamantyl)aminocarbonyl]-terminated, inclusion complex with α-cyclodextrin, prepared with 1-adamantylamine and proton sponge

Conditions
ConditionsYield
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate In N,N-dimethyl-formamide at 4℃;95%
...Expand
Benzyl isothiocyanate
622-78-6

Benzyl isothiocyanate

amantadine hydrochloride
665-66-7

amantadine hydrochloride

1-(adamantane-2-yl)-3-benzylthiourea
29456-84-6

1-(adamantane-2-yl)-3-benzylthiourea

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 80℃; for 8h;95%
1-adamantyl bromomethyl ketone
5122-82-7

1-adamantyl bromomethyl ketone

amantadine hydrochloride
665-66-7

amantadine hydrochloride

1-(adamant-1-yl)-2-((adamant-1-yl)amino)ethan-1-one

1-(adamant-1-yl)-2-((adamant-1-yl)amino)ethan-1-one

Conditions
ConditionsYield
With sodium carbonate In ethanol for 15h; Heating;94%
amantadine hydrochloride
665-66-7

amantadine hydrochloride

1-Adamantanamine
768-94-5

1-Adamantanamine

Conditions
ConditionsYield
With sodium chloride; sodium hydroxide In water94%
With sodium hydroxide In water
With sodium hydroxide In dichloromethane; water
4-((3-formyl-4-hydroxyphenyl)diazenyl)benzenesulfonamide
215177-60-9

4-((3-formyl-4-hydroxyphenyl)diazenyl)benzenesulfonamide

amantadine hydrochloride
665-66-7

amantadine hydrochloride

C23H26N4O3S

C23H26N4O3S

Conditions
ConditionsYield
With acetic acid Reflux;94%
2-hydroxy-5-(p-chlorophenylazo)benzaldehyde
27147-07-5

2-hydroxy-5-(p-chlorophenylazo)benzaldehyde

amantadine hydrochloride
665-66-7

amantadine hydrochloride

C23H24ClN3O

C23H24ClN3O

Conditions
ConditionsYield
With acetic acid Reflux;94%
2,4-Dinitrofluorobenzene
70-34-8

2,4-Dinitrofluorobenzene

amantadine hydrochloride
665-66-7

amantadine hydrochloride

N-(2,4-dinitrophenyl)adamantan-1-amine
149874-11-3

N-(2,4-dinitrophenyl)adamantan-1-amine

Conditions
ConditionsYield
With triethylamine In acetonitrile for 48h; Reflux; Darkness;93%
With potassium carbonate; triethylamine In acetonitrile for 48h; pH=8 - 9; Darkness;50%
Boc-Glu-OBn
30924-93-7

Boc-Glu-OBn

amantadine hydrochloride
665-66-7

amantadine hydrochloride

N-(tert-butyloxycarbonyl)-L-glutamic acid α-benzyl ester γ-(1-adamantylamide)
102651-06-9

N-(tert-butyloxycarbonyl)-L-glutamic acid α-benzyl ester γ-(1-adamantylamide)

Conditions
ConditionsYield
With diphenylphosphoranyl azide; diethylamine In N,N-dimethyl-formamide at 0 - 25℃; for 21h;92%
amantadine hydrochloride
665-66-7

amantadine hydrochloride

phenyl isothiocyanate
103-72-0

phenyl isothiocyanate

1-(adamantane-2-yl)-3-phenylthiourea
25444-88-6

1-(adamantane-2-yl)-3-phenylthiourea

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 80℃; for 8h;92%
Phenethyl isothiocyanate
2257-09-2

Phenethyl isothiocyanate

amantadine hydrochloride
665-66-7

amantadine hydrochloride

1-(adamantane-2-yl)-3-phenethylthiourea

1-(adamantane-2-yl)-3-phenethylthiourea

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 80℃; for 8h;92%
amantadine hydrochloride
665-66-7

amantadine hydrochloride

3-aminoadamantan-1-ol
702-82-9

3-aminoadamantan-1-ol

Conditions
ConditionsYield
With sulfuric acid; nitric acid at 10 - 15℃;90%
With sulfuric acid; nitric acid at 0 - 10℃; for 2h;81%
Stage #1: amantadine hydrochloride With sulfuric acid; nitric acid at 0 - 20℃; Inert atmosphere;
Stage #2: With sodium hydroxide In water		72%
sodium metavanadate

sodium metavanadate

water
7732-18-5

water

amantadine hydrochloride
665-66-7

amantadine hydrochloride

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

4C10H15NH3(1+)*2H(1+)*V10O28(6-)*2HCON(CH3)2*2H2O=(C10H15NH3)4(H2V10O28)*2HCON(CH3)2*2H2O

4C10H15NH3(1+)*2H(1+)*V10O28(6-)*2HCON(CH3)2*2H2O=(C10H15NH3)4(H2V10O28)*2HCON(CH3)2*2H2O

Conditions
ConditionsYield
With aq. HCl In water stirring mixture of adamantane deriv., vanadium compd., water and DMF for few sec. at room temp., adjusting pH to 3 by addn. of 0.1 M aqueous HCl; filtration, keeping in air at room temp. for 2 w, elem. anal.;90%
...Expand
(1R)-4-(2-tert-butoxycarbonylamino-2-carboxyethyl)imidazole-1-carboxylic acid tert-butyl ester

(1R)-4-(2-tert-butoxycarbonylamino-2-carboxyethyl)imidazole-1-carboxylic acid tert-butyl ester

amantadine hydrochloride
665-66-7

amantadine hydrochloride

N,N'-di(tert-butylcarbamate)adamantylamino-D-histidine amide
1190215-11-2

N,N'-di(tert-butylcarbamate)adamantylamino-D-histidine amide

Conditions
ConditionsYield
With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; trimethylamine In dichloromethane at 20℃; Cooling with ice;90%
hydrogenchloride
7647-01-0

hydrogenchloride

18-crown-6 ether
17455-13-9

18-crown-6 ether

amantadine hydrochloride
665-66-7

amantadine hydrochloride

copper dichloride

copper dichloride

2C10H15NH3(1+)*Cu2Cl6(2-)*C12H24O6=(C10H15NH3)2Cu2Cl6(C12H24O6)

2C10H15NH3(1+)*Cu2Cl6(2-)*C12H24O6=(C10H15NH3)2Cu2Cl6(C12H24O6)

Conditions
ConditionsYield
In hydrogenchloride; methanol adamantan-1-aminium chloride, 18-crown-6 were dissolved in MeOH, CuCl2 was added followed by concd. aq. HCl; filtered, slow evapd. at room temp., elam. anal.;90%
...Expand

1-Adamantanamine hydrochloride Chemical Properties

Molecular Structure:
Molecular Formula: C10H18ClN
Molecular Weight: 187.71g/mol
CAS NO: 665-66-7
Mol File: 665-66-7.mol 
EINECS: 211-560-2 
H bond acceptors: 1
H bond donors: 2
Freely Rotating Bonds: 1
Polar Surface Area: 3.24 Å2
Melting Point: >300 °C(lit.)
Boiling point: 225.7 °C at 760 mmHg
Flash Point: 96 °C
Water Solubility: 50 mg/mL
Sensitive: Hygroscopic
Enthalpy of Vaporization: 46.22 kJ/mol
Vapour Pressure: 0.0852 mmHg at 25°C 
Appearance: Crystalline Solid
IUPAC Name: Adamantan-1-amine hydrochloride
InChI : InChI=1/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H     
Smiles: Cl.C1C2CC3CC1CC(C3)(C2)N
Product Categories of Amantadine hydrochloride (CAS NO.665-66-7): Adamantane derivatives; chiral; Adamantanes; Intermediates & Fine Chemicals; Pharmaceuticals; API's; Dopamine receptor

1-Adamantanamine hydrochloride Uses

 Amantadine hydrochloride (CAS NO.665-66-7) is used as NMDA-receptor antagonist.

1-Adamantanamine hydrochloride Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 37mg/kg (37mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Toxicology and Applied Pharmacology. Vol. 15, Pg. 642, 1969.
guinea pig LD50 oral 360mg/kg (360mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Toxicology and Applied Pharmacology. Vol. 15, Pg. 642, 1969.
man LDLo oral 28571ug/kg (28.571mg/kg) BEHAVIORAL: TOXIC PSYCHOSIS

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BLOOD: HEMORRHAGE		 American Journal of Psychiatry. Vol. 145, Pg. 267, 1988.
man LDLo oral 286mg/kg (286mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: TOXIC PSYCHOSIS		 American Journal of Psychiatry. Vol. 145, Pg. 267, 1988.
man TDLo oral 13mg/kg/5D-I (13mg/kg) BEHAVIORAL: EUPHORIA

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"		 American Journal of Psychiatry. Vol. 143, Pg. 1170, 1985.
man TDLo oral 24mg/kg/1D-I (24mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: EXCITEMENT		 Annals of Emergency Medicine. Vol. 19, Pg. 668, 1990.
mouse LD50 intraperitoneal 198mg/kg (198mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
mouse LD50 intravenous 95mg/kg (95mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
mouse LD50 oral 700mg/kg (700mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Toxicology and Applied Pharmacology. Vol. 15, Pg. 642, 1969.
mouse LD50 subcutaneous 290mg/kg (290mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
rat LD50 intraperitoneal 150mg/kg (150mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Toxicology and Applied Pharmacology. Vol. 15, Pg. 642, 1969.
rat LD50 intravenous 90mg/kg (90mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
rat LD50 oral 800mg/kg (800mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
rat LD50 subcutaneous 500mg/kg (500mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 13, Pg. 1269, 1971.
women LDLo oral 50mg/kg (50mg/kg) BEHAVIORAL: COMA

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

CARDIAC: PULSE RATE		 American Journal of Medicine. Vol. 77, Pg. 388, 1984.

1-Adamantanamine hydrochloride Safety Profile

Safety Information of Amantadine hydrochloride (CAS NO.665-66-7):
Hazard Codes: XnHarmful
Risk Statements: 22-40-20/21/22
20: Harmful by inhalation 
21: Harmful in contact with skin 
22: Harmful if swallowed 
40: Limited evidence of a carcinogenic effect 
Safety Statements: 22-36/37-36
22: Do not breathe dust 
36: Wear suitable protective clothing  
37: Wear suitable gloves 

1-Adamantanamine hydrochloride Specification

 The chemical synonyms of Amantadine hydrochloride (CAS NO.665-66-7): 1-Adamantanamine hydrochloride ; AI3-52211 ; Adamantanamine hydrochloride ; Adamantine hydrochloride ; Amantadine HCl ; Amantan ; Amazolon ; Aminoadamantane hydrochloride ; EXP 105-1 ; GP 38026 ; Influenol ; Mydantane ; NSC 83653 ; Symmetrel ; Trivaline ; UNII-M6Q1EO9TD0 ; Tricyclo(3.3.1.1(sup 3,7))decan-1-amine, hydrochloride (9CI) ; Tricyclo(3.3.1.13,7)decan-1-amine, hydrochloride .

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