1-Hydroxy-2-naphthoic acid supplier

Name
1-Hydroxy-2-naphthoic acid
EINECS 201-674-0
CAS No. 86-48-6
Article Data54
CAS DataBase
Density 1.399 g/cm³
Solubility soluble in hot water
Melting Point 195-200 °C (dec.)(lit.)
Formula C₁₁H₈O₃
Boiling Point 367.7 °C at 760 mmHg
Molecular Weight 188.183
Flash Point 190.4 °C
Transport Information
Appearance beige to brown-grey powder
Safety 26-36-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 2-Naphthoicacid, 1-hydroxy- (8CI);1-Hydroxy-2-naphthalenecarboxylic acid;
PSA 57.53000
LogP 2.24360

Synthetic route

: 90-15-3
α-naphthol

: 4861-79-4
magnesium methyl carbonate

: 86-48-6
1-hydroxy-2-naphthoic acid

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 180℃; under 25857.4 Torr; for 6h;	96%

: 90-15-3
α-naphthol

: 17201-44-4
sodium ethyl carbonate

: 86-48-6
1-hydroxy-2-naphthoic acid

Conditions

Conditions	Yield
at 140 - 190℃; under 7600 Torr; for 5h;	93.4%

: 90-15-3
α-naphthol

: 86-48-6
1-hydroxy-2-naphthoic acid

Conditions

Conditions	Yield
With potassium hydrogencarbonate at 200℃; for 5h;	60%
With salicylic acid decarboxylase from Trichosporon moniliiforme; potassium hydrogencarbonate In acetonitrile at 30℃; for 24h; pH=8.5; aq. phosphate buffer; Enzymatic reaction; regioselective reaction;
Multi-step reaction with 4 steps 1.1: 1H-imidazole / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C / Inert atmosphere 1.2: 0 - 20 °C / Inert atmosphere 2.1: water; sodium hydrogencarbonate / N,N-dimethyl-formamide; diethyl ether / 0.5 h / 20 °C / Inert atmosphere 3.1: palladium diacetate; silver(I) acetate; N-tert-butoxycarbonyl-L-leucine; 2,2,2-trifluoroethanol / 1,2-dichloro-ethane / 0.08 h / 95 °C / Inert atmosphere 3.2: 18 h / 95 °C / Inert atmosphere 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / Inert atmosphere View Scheme

: 623-11-0
1-methyl-4-nitrosobenzene

: 858438-04-7
4-isopropyl-benzo[h]chromen-2-one

: 86-48-6
1-hydroxy-2-naphthoic acid

: 1885-78-5
1-nitro-naphthalene-2-carbonitrile

: 86-48-6
1-hydroxy-2-naphthoic acid

Conditions

Conditions	Yield
With barium dihydroxide

: 69796-59-4
3-acetyl-2-methyl-benzo[h]chromen-4-one

: furan-2,3,5(4H)-trione pyridine (1:1)

: 86-48-6
1-hydroxy-2-naphthoic acid

: 67176-26-5
1-hydroxynaphthalene-2-carbonitrile

: 86-48-6
1-hydroxy-2-naphthoic acid

Conditions

Conditions	Yield
With alkaline solution

: 3019-88-3
sodium naphtholate

: 15719-64-9, 15719-76-3, 97762-63-5
methylammonium carbonate

: 86-48-6
1-hydroxy-2-naphthoic acid

Conditions

Conditions	Yield
With 1,4-dioxane
With pyridine

: 2-cyano-naphthalene-1-sulfonic acid ; sodium-salt

: 86-48-6
1-hydroxy-2-naphthoic acid

Conditions

Conditions	Yield
at 200 - 220℃; In der Kalischmelze;

: 104095-33-2
3-benzoyl-5-chloromethyl-dihydro-furan-2-one

: 86-48-6
1-hydroxy-2-naphthoic acid

Conditions

Conditions	Yield
With aluminium trichloride

: 75-44-5
phosgene

: 90-15-3
α-naphthol

: 86-48-6
1-hydroxy-2-naphthoic acid

Conditions

Conditions	Yield
Yield given. Multistep reaction;

: 61035-03-8
2-(diethylamino)-4H-naphtho[1,2-b]pyran-4-one

: 86-48-6
1-hydroxy-2-naphthoic acid

Conditions

Conditions	Yield
With potassium hydroxide In ethanol Heating;

: 28591-61-9
6-Diazo-benzocycloheptene-5,7-dione

: 86-48-6
1-hydroxy-2-naphthoic acid

Conditions

Conditions	Yield
With water

: 574-96-9
1-hydroxy-2-naphthaldehyde

A: 59648-32-7
2-(hydroxymethyl)-1-naphthol

B: 86-48-6
1-hydroxy-2-naphthoic acid

Conditions

Conditions	Yield
With barium dihydroxide; formaldehyd at 100 - 110℃; for 4h;	A 85 % Chromat. B 9 % Chromat.

: 875224-19-4
3-ethyl-2-methyl-benzo[h]chromen-4-one

aqueous alkaline solution: aqueous alkaline solution

: 86-48-6
1-hydroxy-2-naphthoic acid

: 3-acetyl-benzo[h]chromene-2,4-dione

KOH-solution: KOH-solution

: 86-48-6
1-hydroxy-2-naphthoic acid

: 2,4-dioxo-3,4-dihydro-2H-benzo[h]chromene-3-carboxylic acid ethyl ester

KOH-solution: KOH-solution

: 86-48-6
1-hydroxy-2-naphthoic acid

: 95703-28-9
3-benzyl-4-methyl-benzo[h]chromen-2-one

KOH-solution: KOH-solution

A: 2550-26-7
4-Phenyl-2-butanone

B: 86-48-6
1-hydroxy-2-naphthoic acid

...Expand

: 861353-04-0
4-methyl-3-phenyl-benzo[h]chromen-2-one

KOH-solution: KOH-solution

A: 10166-08-2
2-methyl-benzeneacetaldehyde

B: 86-48-6
1-hydroxy-2-naphthoic acid

...Expand

: 7446-70-0
aluminium trichloride

: 104095-33-2
3-benzoyl-5-chloromethyl-dihydro-furan-2-one

: 71-43-2
benzene

A: 94540-41-7
phenyl(1,2,3,4-tetrahydronaphthalen-1-yl)methanone

B: 112863-69-1
1,4,5-triphenyl-pentan-1-one

C: 86-48-6
1-hydroxy-2-naphthoic acid

...Expand

: 90-15-3
α-naphthol

: 124-38-9
carbon dioxide

: 86-48-6
1-hydroxy-2-naphthoic acid

Conditions

Conditions	Yield
With sodium
With sodium; toluene
With potassium carbonate under 36775.4 Torr;
With potassium hydrogencarbonate; glycerol

1-oxy-3.4-dihydro-naphthoic acid-(2)-ethyl ester: 1-oxy-3.4-dihydro-naphthoic acid-(2)-ethyl ester

: 86-48-6
1-hydroxy-2-naphthoic acid

Conditions

Conditions	Yield
With sodium; sodium cyclohexanolate; cyclohexanol at 190 - 200℃;

: 124-38-9
carbon dioxide

: 3019-88-3
sodium naphtholate

: 86-48-6
1-hydroxy-2-naphthoic acid

Conditions

Conditions	Yield
at 135℃;

: 124-38-9
carbon dioxide

alkali-α-naphtholate: alkali-α-naphtholate

: 86-48-6
1-hydroxy-2-naphthoic acid

Conditions

Conditions	Yield
With alkali sulfite

: 15719-64-9, 15719-76-3, 97762-63-5
methylammonium carbonate

alkali salt of α-naphthol: alkali salt of α-naphthol

: 86-48-6
1-hydroxy-2-naphthoic acid

Conditions

Conditions	Yield
Erhitzen des entstandenen Salzes im Autoklaven auf 120-140grad;
Erhitzen des entstandenen Salzes im Autoklaven auf 120-140grad;

sodium salt of/the/ 2-cyano-naphthalene-sulfonic acid-(1): sodium salt of/the/ 2-cyano-naphthalene-sulfonic acid-(1)

: 86-48-6
1-hydroxy-2-naphthoic acid

Conditions

Conditions	Yield
at 200 - 220℃; durch Kalischmelze;

: 90-15-3
α-naphthol

: 124-38-9
carbon dioxide

sodium: sodium

: 86-48-6
1-hydroxy-2-naphthoic acid

...Expand

: 90-15-3
α-naphthol

: 124-38-9
carbon dioxide

: 108-88-3
toluene

sodium: sodium

: 86-48-6
1-hydroxy-2-naphthoic acid

...Expand

: 1885-78-5
1-nitro-naphthalene-2-carbonitrile

aq. barium hydroxide solution: aq. barium hydroxide solution

: 86-48-6
1-hydroxy-2-naphthoic acid

: 77-78-1
dimethyl sulfate

: 86-48-6
1-hydroxy-2-naphthoic acid

: 948-03-8
1-hydroxy-naphthalene-2-carboxylic acid methyl ester

Conditions

Conditions	Yield
With lithium hydroxide In tetrahydrofuran for 1h; Methylation; esterification; Heating;	100%
Stage #1: 1-hydroxy-2-naphthoic acid With lithium hydroxide In tetrahydrofuran for 0.5h; Stage #2: dimethyl sulfate In tetrahydrofuran for 3h; Heating;	95.9%
Stage #1: 1-hydroxy-2-naphthoic acid With triethylamine In acetone for 0.25h; Inert atmosphere; Stage #2: dimethyl sulfate In acetone at 55℃; for 12h; Inert atmosphere;	95%

: 74-88-4
methyl iodide

: 86-48-6
1-hydroxy-2-naphthoic acid

: 6039-59-4
methyl 1-methoxy-2-naphthoate

Conditions

Conditions	Yield
With potassium carbonate In acetone Reflux;	100%
With potassium carbonate In acetone Reflux;	96%
With potassium carbonate In acetone for 18h; Reflux;	95%

: 71125-38-7
meloxicam

: 86-48-6
1-hydroxy-2-naphthoic acid

: 1174325-92-8
4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide 1-hydroxy-2-naphthoic acid (1:1)

Conditions

Conditions	Yield
In tetrahydrofuran for 0.5h;	100%
In tetrahydrofuran Product distribution / selectivity;
In dimethylsulfoxide-d6; water at 25 - 90℃; Solvent;	71 g

: 59721-28-7
camostat

: 86-48-6
1-hydroxy-2-naphthoic acid

: N,N-dimethyl-carbamoylmethyl p-(p-guanidinobenzoyloxy)phenylacetate xinafoate

Conditions

Conditions	Yield
In water; isopropyl alcohol at 25 - 60℃;	99.1%

: 86-48-6
1-hydroxy-2-naphthoic acid

: 5813-37-6
4-bromo-1-hydroxy-2-naphthoic acid

Conditions

Conditions	Yield
With bromine In acetic acid at 20℃;	99%
With bromine; acetic acid at 20℃;	99%
With bromine In acetic acid at 20℃; Inert atmosphere;	92%

: 71-23-8
propan-1-ol

: 23519-77-9
zirconium tetrapropoxide

: 86-48-6
1-hydroxy-2-naphthoic acid

: Zr6O2(OC3H7)16(O2CC10H6O)2(C3H7OH)2

Conditions

Conditions	Yield
In propan-1-ol (argon); storing in a Schlenk tube (ambient temp., 14 d);	99%

...Expand

: 81-16-3
2-aminonaphthalenesulfonic acid

: 86-48-6
1-hydroxy-2-naphthoic acid

A: 1402066-96-9
2-[(1-hydroxy-2-naphthalenyl)azo]-1-naphthalenesulfonic acid sodium salt

B: 1-hydroxy-4-[(1-sulfo-2-naphthalenyl)azo]-2-naphthalenecarboxylic acid disodium salt

Conditions

Conditions	Yield
Stage #1: 2-aminonaphthalenesulfonic acid With hydrogenchloride; sodium hydroxide; sodium nitrite In water at 0℃; for 0.5h; Stage #2: 1-hydroxy-2-naphthoic acid With sodium carbonate In ethanol; water at 0℃;	A 12% B 97%

...Expand

: 86-48-6
1-hydroxy-2-naphthoic acid

: 6301-40-2
1-acetoxy-2-naphthoic acid

Conditions

Conditions	Yield
With sulfuric acid In acetic anhydride at 100℃; for 0.166667h;	97%

: 77-78-1
dimethyl sulfate

: 86-48-6
1-hydroxy-2-naphthoic acid

: 6039-59-4
methyl 1-methoxy-2-naphthoate

Conditions

Conditions	Yield
With potassium carbonate In acetone at 50℃; Temperature;	96%
Stage #1: 1-hydroxy-2-naphthoic acid With potassium carbonate In acetone for 0.25h; Inert atmosphere; Stage #2: dimethyl sulfate In acetone at 55℃; for 12h; Inert atmosphere;	95%
With potassium carbonate In acetone Heating;
With potassium carbonate In acetone for 8h; Reflux;

: 86-48-6
1-hydroxy-2-naphthoic acid

A: 179041-74-8
9-methoxy-2-amino-1,2,3,4-tetrahydroanthracene

B: 179041-75-9
10-methoxy-2-amino-1,2,3,4-tetrahydrophenanthrene

Conditions

Conditions	Yield
	A 95% B n/a

: 1310717-02-2
3,6-diazabicyclo[3.1.1]heptan-3-yl(cyclopropyl) methanone

: 86-48-6
1-hydroxy-2-naphthoic acid

: 1400593-10-3
C9H14N2O*C11H8O3

Conditions

Conditions	Yield
In Isopropyl acetate; water at 60℃;	95%

: (R)-N-(3-(5-fluoro-2-(2-fluoro-3-(methylsulfonyl)phenylamino)pyrimidin-4-yl)-1H-indol-7-yl)-3-methoxy-2-(4-methylpiperazin-1-yl)propanamide

: 86-48-6
1-hydroxy-2-naphthoic acid

: (R)-N-(3-(5-fluoro-2-((2-fluoro-3-(methylsulfonyl)phenyl)amino)pyrimidin-4-yl)-1H-indol-7-yl)-3-methoxy-2-(4-methylpiperazin-1-yl)propanamide xinafoic acid

Conditions

Conditions	Yield
Stage #1: (R)-N-(3-(5-fluoro-2-(2-fluoro-3-(methylsulfonyl)phenylamino)pyrimidin-4-yl)-1H-indol-7-yl)-3-methoxy-2-(4-methylpiperazin-1-yl)propanamide In methanol; ethyl acetate at 65℃; Inert atmosphere; Stage #2: 1-hydroxy-2-naphthoic acid In methanol; ethyl acetate at 50℃; Inert atmosphere;	95%

: 89365-50-4
salmeterol

: 86-48-6
1-hydroxy-2-naphthoic acid

: salmeterol xinafoate

Conditions

Conditions	Yield
In acetone at 30℃; for 0.666667h; Temperature; Solvent;	94.1%
In acetone at 25 - 45℃; for 1.5h;	69%
In diethyl ether at 20℃; for 16h;
In isopropyl alcohol
Stage #1: salmeterol With pyrographite In methanol at 25 - 30℃; for 0.5h; Stage #2: 1-hydroxy-2-naphthoic acid In methanol at 18 - 30℃; for 3h;	20.75 g

: 50-00-0
formaldehyd

: 86-48-6
1-hydroxy-2-naphthoic acid

: 1175-41-3
4,4'-methylenebis(1-hydroxy-2-naphthoic acid)

Conditions

Conditions	Yield
With sulfuric acid 1.) 90 deg C, 6 h, 2.) RT, 12 h;	94%

: 64-17-5
ethanol

: 86-48-6
1-hydroxy-2-naphthoic acid

: 33950-71-9
ethyl 1-hydroxy-2-naphthoate

Conditions

Conditions	Yield
With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In toluene at 20℃; for 7.5h; Inert atmosphere;	93%
With sulfuric acid
Stage #1: 1-hydroxy-2-naphthoic acid With thionyl chloride Stage #2: ethanol With triethylamine
With sulfuric acid Reflux;

: 77-78-1
dimethyl sulfate

: 86-48-6
1-hydroxy-2-naphthoic acid

: 883-21-6
1-methoxy-2-naphthoic acid

Conditions

Conditions	Yield
Stage #1: dimethyl sulfate; 1-hydroxy-2-naphthoic acid With potassium carbonate Stage #2: With lithium hydroxide In tetrahydrofuran; water	92%
With sodium hydroxide In water

: 1416767-53-7
5,5-dibenzyl-2,3,4,5-tetrahydropyridine

: 86-48-6
1-hydroxy-2-naphthoic acid

: 1416767-44-6
12,12-dibenzyl-10,11,12,12a-tetrahydronaphtho[2,1-e]pyrido[2,1-b][1,3]oxazin-7(9H)-one

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In toluene at 90℃; for 20h; Inert atmosphere;	92%
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In toluene at 90℃; for 20h;	92%

: 100-39-0
benzyl bromide

: 86-48-6
1-hydroxy-2-naphthoic acid

: 1-benzyloxynaphthalene-2-carboxylic acid

Conditions

Conditions	Yield
With potassium carbonate; tetrabutylammomium bromide In tetrahydrofuran at 30℃; for 0.166667h;	91%

: 67-56-1
methanol

: 86-48-6
1-hydroxy-2-naphthoic acid

: 948-03-8
1-hydroxy-naphthalene-2-carboxylic acid methyl ester

Conditions

Conditions	Yield
With sulfuric acid	90%
With sulfuric acid	90%
With sulfuric acid at 80℃; for 8h;	80%

: 86-48-6
1-hydroxy-2-naphthoic acid

: 33950-71-9
ethyl 1-hydroxy-2-naphthoate

Conditions

Conditions	Yield
With ethanol; sulfuric acid for 8h; Reflux;	90%
Multi-step reaction with 2 steps 1: SOCl2 / tetrahydrofuran / 2 h / 20 °C 2: 88 percent / 0.17 h / 120 °C / microwave irradiation View Scheme
Multi-step reaction with 2 steps 1: petroleum ether; thionyl chloride View Scheme

: 86-48-6
1-hydroxy-2-naphthoic acid

: 352662-32-9
2-chloro-4H-naphtho[1,2-d][1,3,2]dioxaphosphinin-4-one

Conditions

Conditions	Yield
With triethylamine; phosphorus trichloride In toluene at 20℃;	90%
With anhydrous phosphorus trichloride In toluene	75%
With Lewatit MP-62; phosphorus trichloride In toluene at 20℃; Product distribution / selectivity;	75%
With triethylamine; phosphorus trichloride In toluene at 0 - 20℃; Product distribution / selectivity;	74.35%

: 105-36-2
ethyl bromoacetate

: 86-48-6
1-hydroxy-2-naphthoic acid

: 1009813-72-2
1-ethoxycarbonylmethoxynaphthalene-2-carboxylic acid

Conditions

Conditions	Yield
With potassium carbonate; tetrabutylammomium bromide In tetrahydrofuran at 30℃; for 0.166667h;	90%

: 106-95-6
allyl bromide

: 86-48-6
1-hydroxy-2-naphthoic acid

: 1009813-71-1
1-(2-propenoxy)-2-naphthoic acid

Conditions

Conditions	Yield
With potassium carbonate; tetrabutylammomium bromide In tetrahydrofuran at 30℃; for 0.166667h;	90%

: manganese(II) hydroxide

: 7732-18-5
water

: 86-48-6
1-hydroxy-2-naphthoic acid

: 869582-71-8
tetraaquabis(1-hydroxy-2-naphthoato-κO)manganese(II)

Conditions

Conditions	Yield
In water suspn. of Mn(OH)2 in H2O added to suspn. of acid in water; mixt. heated at 313 K for 6 wk; sepd. by decantation; dried at room temp.;	90%

...Expand

: 74-88-4
methyl iodide

: 86-48-6
1-hydroxy-2-naphthoic acid

: 883-21-6
1-methoxy-2-naphthoic acid

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 10h; Cooling with ice;	90%

: 86-48-6
1-hydroxy-2-naphthoic acid

: C22H14N2O3

Conditions

Conditions	Yield
With Vilsmeier reagent; hydrazine hydrate; triethylamine In acetonitrile at 20℃; for 8h;	90%

: 496-72-0
4-methyl-1,2-diaminobenzene

: 86-48-6
1-hydroxy-2-naphthoic acid

: 2-(5-methyl-1H-benzo[d]imidazol-2-yl)naphthalen-1-ol

Conditions

Conditions	Yield
With polyphosphoric acid for 0.166667h; Microwave irradiation;	90%

1-Hydroxy-2-naphthoic acid Chemical Properties

Product Name: 1-Hydroxy-2-naphthoic acid (CAS NO.86-48-6)
IUPAC Name: 1-hydroxynaphthalene-2-carboxylic acid

MF: C₁₁H₈O₃
MW: 188.18
EINECS: 201-674-0
MP: 195-200 °C (dec.)(lit.)
Fp: 150 °C
Density: 1.399 g/cm³
Boiling Point: 367.7 °C at 760 mmHg
Water Solubility: Solubility in hot water
Appearance: Slightly gray granules.
Index of Refraction: 1.716
Molar Refractivity: 52.9 cm³
Molar Volume: 134.5 cm³
Categories: Intermediates of Dyes and Pigments

1-Hydroxy-2-naphthoic acid Uses

1-Hydroxy-2-naphthoic acid (CAS NO.86-48-6) is used as coupler and also used as the additive of battery.

1-Hydroxy-2-naphthoic acid Safety Profile

Safety Information of 1-Hydroxy-2-naphthoic acid (CAS NO.86-48-6):
Hazard Codes: Xi
Risk Statements: 36/37/38
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36-37/39
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37/39: Wear suitable gloves and eye/face protection
WGK Germany: 3
HS Code: 29182910

1-Hydroxy-2-naphthoic acid Specification

1-Hydroxy-2-naphthoic acid , its CAS NO. is 86-48-6, the synonyms are 1-hydroxy-2-naphthalenecarboxylicaci ;1-hydroxy-2-Naphthalenecarboxylicacid

Product Name

1-Hydroxy-2-naphthoic acid

Synthetic route

1-Hydroxy-2-naphthoic acid Chemical Properties

1-Hydroxy-2-naphthoic acid Uses

1-Hydroxy-2-naphthoic acid Safety Profile

1-Hydroxy-2-naphthoic acid Specification

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