Product Name

  • Name

    1-Phenyl-1-propanol

  • EINECS 202-256-0
  • CAS No. 93-54-9
  • Article Data544
  • CAS DataBase
  • Density 0.994 g/cm3
  • Solubility insoluble in water
  • Melting Point
  • Formula C9H12O
  • Boiling Point 219 °C at 760 mmHg
  • Molecular Weight 136.194
  • Flash Point 97.3 °C
  • Transport Information UN 2810
  • Appearance clear colorless liquid
  • Safety 23-24/25
  • Risk Codes 22
  • Molecular Structure Molecular Structure of 93-54-9 (1-Phenyl-1-propanol)
  • Hazard Symbols HarmfulXn
  • Synonyms Benzylalcohol, a-ethyl- (8CI);(RS)-1-Phenylpropan-1-ol;(RS)-1-Phenylpropanol;1-Hydroxy-1-phenylpropane;1-Phenyl-1-hydroxypropane;1-Phenyl-n-propanol;1-Propanol, 1-phenyl-;Bilergon;Carbicol;Ejibil;Epatoxfen;Felicur;Felitrope;Fepar;Livonal;NSC 41708;Phenicol;Phenycholon;Phenylchol;SH 261;a-Ethylbenzenemethanol;a-Hydroxypropylbenzene;
  • PSA 20.23000
  • LogP 2.13000

Synthetic route

ethylmagnesium bromide
925-90-6

ethylmagnesium bromide

benzaldehyde
100-52-7

benzaldehyde

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Conditions
ConditionsYield
With methylaluminum bis(2,6-di-tert-butylphenoxide) In diethyl ether; toluene at -78℃; for 2h;100%
In diethyl ether at 0 - 20℃;87%
Stage #1: ethylmagnesium bromide; benzaldehyde In tetrahydrofuran at 30℃; for 24h; Inert atmosphere;
Stage #2: With water In tetrahydrofuran Inert atmosphere;
73%
1-phenyl-propan-1-one
93-55-0

1-phenyl-propan-1-one

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Conditions
ConditionsYield
With potassium hydride; ditriptylethylborane In tetrahydrofuran for 0.0833333h;100%
With zirconium dioxide hydrate; isopropyl alcohol at 130℃; for 0.5h; Meerwein-Ponndorf-Verley Reduction;100%
With hydrogen In methanol at 40℃; for 24h; chemoselective reaction;100%
1-Phenyl-2-propen-1-ol
4393-06-0

1-Phenyl-2-propen-1-ol

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Conditions
ConditionsYield
With C35H41ClFeIrPS; hydrogen; sodium methylate In tetrahydrofuran at 25℃; under 22502.3 Torr; for 2h; Reagent/catalyst; Autoclave; Inert atmosphere;100%
With sodium tetrahydroborate; C11H18Cl2CoN2S; hydrogen In isopropyl alcohol at 100℃; under 37503.8 Torr; for 16h; Glovebox; Autoclave;97%
With 1,1'-bis(diphenylphosphino)ferrocene; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; Butane-1,4-diol; potassium tert-butylate at 110℃; for 24h; Inert atmosphere;92%
2-(1-phenyl-propoxy)-tetrahydro-pyran
321884-15-5

2-(1-phenyl-propoxy)-tetrahydro-pyran

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Conditions
ConditionsYield
silica-supported prop-1-ylsulfonic acid In methanol99.6%
With tetra-N-butylammonium tribromide In methanol at 20℃; for 1h;97%
With tetra-N-butylammonium tribromide In methanol for 1.2h;97%
With trichloroisocyanuric acid In methanol at 20℃; for 4h;92%
diethylzinc
557-20-0

diethylzinc

benzaldehyde
100-52-7

benzaldehyde

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Conditions
ConditionsYield
With (1R,2S)-2-aminomethyl-2-hydroxy-1,7,7-trimethylbicyclo[2.2.1]heptane In hexane for 48h;99%
With polystyrene bond triphenylphosphonium chloride In toluene at 0 - 23℃; Inert atmosphere; chemoselective reaction;99%
With 15-crown-5; sodium iodide In toluene at 0 - 23℃; for 24h; Reagent/catalyst; Solvent; Inert atmosphere; Schlenk technique;99%
1-Phenyl-2-propyn-1-ol
4187-87-5

1-Phenyl-2-propyn-1-ol

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Conditions
ConditionsYield
With hydrogen; TMSB; palladium In ethanol at 20℃; under 760 Torr; for 20h;98%
With riboflavin tetrabutyrate; oxygen; hydrazine hydrate In acetonitrile at 30℃; under 760.051 Torr; for 30h;92%
With oxygen; hydrazine hydrate; riboflavin 2’,3’,4’,5’-tetrabutanoate In acetonitrile at 25 - 30℃; for 30h; chemoselective reaction;92%
tetraethyllead(IV)
78-00-2

tetraethyllead(IV)

benzaldehyde
100-52-7

benzaldehyde

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Conditions
ConditionsYield
With titanium tetrachloride In dichloromethane at -78 - -30℃; Product distribution; further aldehydes and tetraalkylleads; reaction with mixed tetraalkylleads; other conditions;98%
With titanium tetrachloride In dichloromethane at -78 - -30℃;98%
With titanium tetrachloride In dichloromethane at -78 - -30℃;96%
triethyl-butyl plumbane
64346-32-3

triethyl-butyl plumbane

benzaldehyde
100-52-7

benzaldehyde

A

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

B

1-Phenyl-1-pentanol
583-03-9

1-Phenyl-1-pentanol

Conditions
ConditionsYield
With titanium tetrachloride In dichloromethane at -78 - -30℃;A 98%
B 1.7%
1-phenyl-1-tert-butyldimethylsiloxypropane
136116-42-2

1-phenyl-1-tert-butyldimethylsiloxypropane

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Conditions
ConditionsYield
With tetra-N-butylammonium tribromide In methanol for 7h;98%
With N-iodo-succinimide In methanol at 20℃; for 19h;95%
With methanol at 20℃; for 3.33333h;93%
sulfonic acid functionalized nanoporous silica In methanol at 35℃; for 12h;87%
With tetrabutyl ammonium fluoride
ethyl sodium ; compound with diethyl zinc

ethyl sodium ; compound with diethyl zinc

benzaldehyde
100-52-7

benzaldehyde

A

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

B

benzyl alcohol
100-51-6

benzyl alcohol

Conditions
ConditionsYield
In toluene for 0.166667h; Alkylation; reduction; Title compound not separated from byproducts.;A 97%
B 2%
benzaldehyde
100-52-7

benzaldehyde

C4H10Zn*C2H5Li

C4H10Zn*C2H5Li

A

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

B

benzyl alcohol
100-51-6

benzyl alcohol

Conditions
ConditionsYield
In toluene for 24h; Alkylation; reduction; Title compound not separated from byproducts.;A 97%
B 2%
ethylmagnesium iodide
10467-10-4

ethylmagnesium iodide

benzaldehyde
100-52-7

benzaldehyde

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Conditions
ConditionsYield
In diethyl ether Heating;96%
With diethyl ether
With 2,3-Dimethylaniline; benzene
(1-Chloro-propyl)-benzene
934-11-2

(1-Chloro-propyl)-benzene

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Conditions
ConditionsYield
With iron(III) sulfate; water In toluene at 110℃; for 1h; Ionic liquid;96%
In ethanol at 25℃; Rate constant; Kinetics; Thermodynamic data; ΔH(excit.), ΔS(excit.);
1-(4-chlorophenyl)-1-propanol
13856-85-4

1-(4-chlorophenyl)-1-propanol

A

Propylbenzene
103-65-1

Propylbenzene

B

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Conditions
ConditionsYield
With potassium hydroxide; hydrogen; Aliquat 336; palladium on activated charcoal In 2,2,4-trimethylpentane at 50℃; for 0.833333h; Product distribution; various time, solvents; also in the presence of various aromatic halides as promoters; further benzylic alcohols;A 96%
B 4%
1-phenylpropylene oxide
23355-97-7

1-phenylpropylene oxide

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Conditions
ConditionsYield
With sodium tert-pentoxide; sodium hydride; zinc(II) chloride In 1,2-dimethoxyethane at 65℃; for 6h;95%
1-phenylpropyl trimethylsilyl ether
62559-30-2

1-phenylpropyl trimethylsilyl ether

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Conditions
ConditionsYield
With silica triflate In methanol for 0.0666667h; Heating;95%
With 1-butyl-3-methylimidazolium chloride at 20℃; for 1.33h;94%
With silica gel; iodic acid In water for 0.00833333h; microwave irradiation;90%
2-(1-phenylpropoxy)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-(1-phenylpropoxy)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Conditions
ConditionsYield
With silica gel In methanol for 4h; Reflux;95%
With sodium hydroxide In tetrahydrofuran; diethyl ether; water at 20℃; for 0.5h;
With silica gel In methanol at 60℃; for 6h; Inert atmosphere; Schlenk technique; Glovebox;
With air In diethyl ether129 mg
With dihydrogen peroxide; sodium hydroxide Inert atmosphere;145 mg
2-phenyloxetane
4436-23-1

2-phenyloxetane

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Conditions
ConditionsYield
With dibutylmagnesium; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In toluene at 75℃; for 24h; regioselective reaction;95%
benzaldehyde
100-52-7

benzaldehyde

ethyl iodide
75-03-6

ethyl iodide

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Conditions
ConditionsYield
Stage #1: ethyl iodide With 1-butylpyridinium bromide; N-butylpyridinium tetrafluoroborate; zinc at 50℃; for 1h;
Stage #2: benzaldehyde at 20℃; for 12h;
94%
Stage #1: ethyl iodide With magnesium In diethyl ether Inert atmosphere;
Stage #2: benzaldehyde In diethyl ether at 0 - 20℃; for 2h; Grignard Reaction; Inert atmosphere;
84%
Stage #1: ethyl iodide With N-butylpyridinium tetrafluoroborate at 20℃; for 1h;
Stage #2: benzaldehyde With pyridine at 20℃; for 12h; Further stages.;
83%
With diethyl ether; calcium
benzaldehyde
100-52-7

benzaldehyde

C4H10Zn*C4H9O(1-)*K(1+)

C4H10Zn*C4H9O(1-)*K(1+)

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Conditions
ConditionsYield
In toluene for 0.25h; Alkylation;94%
C6H5COHCHCH3
4397-07-3

C6H5COHCHCH3

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Conditions
ConditionsYield
With hydrogen In ethanol; water at 120℃; under 37503.8 Torr; chemoselective reaction;94%
Propylbenzene
103-65-1

Propylbenzene

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Conditions
ConditionsYield
With C20H24B10Cl4FeN6; dihydrogen peroxide In methanol at 20℃; for 6h;93%
With lithium aluminium tetrahydride; 2,2'-azobis(isobutyronitrile); oxygen Kinetics; relative chain propagation rates;
With NADPH In dimethyl sulfoxide at 30℃; pH=7.4; Product distribution; Further Variations:; Reagents;99 % Chromat.
triethyl borane
97-94-9

triethyl borane

benzaldehyde
100-52-7

benzaldehyde

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)nickel (0); tri-tert-butyl phosphine; 1-(Prop-2-enyl)-1,2,3,4,5-pentamethylcyclopenta-2,4-dien In hexane; toluene at 0℃; for 24h;93%
With tri-tert-butyl phosphine; bis(1,5-cyclooctadiene)nickel (0) In hexane; water at 20℃; for 20h; Product distribution; Further Variations:; Catalysts; Reagents; Solvents;81%
With tetra-(n-butyl)ammonium iodide In tetrahydrofuran; N,N-dimethyl-formamide for 7h; Ambient temperature; electrolysis with Pt/Cu electrodes;74%
1-Phenyl-2-propen-1-ol
4393-06-0

1-Phenyl-2-propen-1-ol

A

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

B

1-phenyl-propan-1-one
93-55-0

1-phenyl-propan-1-one

Conditions
ConditionsYield
With C35H41FePRhS; hydrogen; sodium methylate In tetrahydrofuran at 82℃; under 22502.3 Torr; for 16h; Autoclave; Inert atmosphere;A 7%
B 93%
With triethylamine; palladium on activated charcoal In toluene at 150℃; for 3h;A 5 % Spectr.
B 91 % Spectr.
With dichloro(η3:η2:η3-dodeca-2,6,10-triene-1,12-diyl)ruthenium(IV); water; sodium formate at 100℃; for 24h; Inert atmosphere;A 82 %Chromat.
B n/a
cis-1-phenylpropene oxide
4541-87-1

cis-1-phenylpropene oxide

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Conditions
ConditionsYield
With alkaline hydrogen peroxide; lithium triethylborohydride In tetrahydrofuran for 1h;92%
(E)-3-(N,N-dimethylamino)-1-phenyl-2-propen-1-one
1131-80-2, 1201-93-0, 31919-75-2

(E)-3-(N,N-dimethylamino)-1-phenyl-2-propen-1-one

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; for 12h; Reagent/catalyst; Temperature;92%
potassium trifluoro(1-phenylpropan-2-yl)borate
1190991-23-1

potassium trifluoro(1-phenylpropan-2-yl)borate

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Conditions
ConditionsYield
With rose bengal; triethylamine In ethanol at 25℃; for 12h; Schlenk technique; Irradiation;91%
triethyl phosphate
78-40-0

triethyl phosphate

benzaldehyde
100-52-7

benzaldehyde

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Conditions
ConditionsYield
With lithium In tetrahydrofuran at -30℃; for 0.25h;90%
benzaldehyde
100-52-7

benzaldehyde

C15H33NO6*2C2H5BrMg

C15H33NO6*2C2H5BrMg

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 0.0833333h;90%
In tetrahydrofuran at 20℃; further carbonyl compounds, further solvents, further Grignard/TDA-1 complexes;90%
1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

1-phenyl-propan-1-one
93-55-0

1-phenyl-propan-1-one

Conditions
ConditionsYield
With silica-supported Jones reagent In dichloromethane for 0.00269444h;100%
With ruthenium trichloride; iodobenzene; potassium peroxomonosulfate In water; acetonitrile at 20℃; for 0.3h;100%
With ruthenium trichloride; iodobenzene; potassium peroxymonosulfate In water; acetonitrile at 20℃; for 0.3h; Inert atmosphere;100%
1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

acetic anhydride
108-24-7

acetic anhydride

1-phenylpropyl acetate
83808-03-1, 2114-29-6

1-phenylpropyl acetate

Conditions
ConditionsYield
indium(III) chloride at 20℃; for 1h;100%
With pyridine99%
With SiO2-supported Co(II) Salen complex catalyst at 50℃; for 0.75h;99%
1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

ethyl iodide
75-03-6

ethyl iodide

(±)-(1-iodopropyl)benzene
4119-41-9

(±)-(1-iodopropyl)benzene

Conditions
ConditionsYield
Stage #1: ethyl iodide With magnesium; N-butylpyridinium tetrafluoroborate at 20℃; for 1h;
Stage #2: 1-Phenyl-1-propanol With magnesium iodide at 20℃; for 12h; Further stages.;
100%
oxalyl dichloride
79-37-8

oxalyl dichloride

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

2-oxo-2-(1-phenylpropoxy)acetic acid

2-oxo-2-(1-phenylpropoxy)acetic acid

Conditions
ConditionsYield
In diethyl ether at 0 - 20℃;100%
1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

chloromethyldiphenylsilane
144-79-6

chloromethyldiphenylsilane

1-phenylpropan-1-yl diphenylmethylsilyl ether
60632-85-1

1-phenylpropan-1-yl diphenylmethylsilyl ether

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 20℃; for 2h; Inert atmosphere;100%
3,4-dihydro-2H-pyran
110-87-2

3,4-dihydro-2H-pyran

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

2-(1-phenyl-propoxy)-tetrahydro-pyran
321884-15-5

2-(1-phenyl-propoxy)-tetrahydro-pyran

Conditions
ConditionsYield
silica-supported prop-1-ylsulfonic acid In acetonitrile for 0.166667h;99.8%
With C8H15N2O3S(1+)*Cl5Zn2(1-) In neat (no solvent) at 20℃; for 0.75h; Green chemistry;92%
With trichloroisocyanuric acid at 60 - 80℃; for 6h;90%
bismuth(III) nitrate In dichloromethane at 20℃; for 0.3h;90%
With tetra-N-butylammonium tribromide In dichloromethane at 20℃; for 0.41h;85%
1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

methyl iodide
74-88-4

methyl iodide

(1-methoxypropyl)benzene
59588-12-4

(1-methoxypropyl)benzene

Conditions
ConditionsYield
Stage #1: 1-Phenyl-1-propanol With sodium hydride In tetrahydrofuran at 20℃; for 1h;
Stage #2: methyl iodide at 20℃;
99.2%
1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Propylbenzene
103-65-1

Propylbenzene

Conditions
ConditionsYield
With chloro-trimethyl-silane; acetonitrile; sodium iodide In hexane for 24h; Ambient temperature;99%
With chloro-trimethyl-silane; acetonitrile; sodium iodide In hexane for 24h; Ambient temperature;99%
With hydrogen In ethanol at 80℃; under 2250.23 Torr; for 3h; Catalytic behavior; Temperature; Solvent; Inert atmosphere;94%
Isopropenyl acetate
108-22-5

Isopropenyl acetate

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

Conditions
ConditionsYield
With dicarbonylchlorido(pentabenzylcyclopentadienyl)ruthenium; potassium tert-butylate; sodium carbonate In tetrahydrofuran; toluene at 23℃; for 9h; Inert atmosphere; dynamic kinetic resolution; Enzymatic reaction; optical yield given as %ee; enantioselective reaction;99%
With Candida antarctica lipase B; potassium tert-butylate; sodium carbonate; [chlorodicarbonyl(η-pentaphenylcyclopentadienyl)]Ru(II) In toluene at 20℃; for 17h;90%
Stage #1: Isopropenyl acetate; 1-Phenyl-1-propanol With Novozym 435 In toluene at 60℃; for 1h; Enzymatic reaction;
Stage #2: In toluene at 60℃; for 21h;
n/a
1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

(-)-(S)-(1-chloropropyl)benzene
10316-10-6

(-)-(S)-(1-chloropropyl)benzene

Conditions
ConditionsYield
With 1,3,5-trichloro-2,4,6-triazine; dimethyl sulfoxide at 20℃; for 0.416667h; chemoselective reaction;99%
1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

2,6-dimethyl-1-chlorobenzene
6781-98-2

2,6-dimethyl-1-chlorobenzene

2-(2,6-dimethylphenyl)-1-phenyl-1-propanone

2-(2,6-dimethylphenyl)-1-phenyl-1-propanone

Conditions
ConditionsYield
Stage #1: 1-Phenyl-1-propanol With allylchloro[1,3-bis(2,6-di-isopropylphenyl)imidazol-2-ylidine]palladium(II); para-chlorotoluene; potassium tert-butylate In toluene at 40℃; for 2.5h; Inert atmosphere;
Stage #2: 2,6-dimethyl-1-chlorobenzene In toluene at 80℃; for 2h; Inert atmosphere;
99%
1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

chlorobenzene
108-90-7

chlorobenzene

1,2-diphenylpropan-1-one
2042-85-5

1,2-diphenylpropan-1-one

Conditions
ConditionsYield
With allylchloro[1,3-bis(2,6-di-isopropylphenyl)imidazol-2-ylidine]palladium(II); potassium tert-butylate In toluene at 80℃; for 1.5h; Inert atmosphere;99%
1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane
5123-13-7

5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane

1,1-Diphenyl-propan-1-ol
5180-33-6

1,1-Diphenyl-propan-1-ol

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)nickel (0); potassium tert-butylate; chlorobenzene; cesium fluoride; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride In toluene at 80℃; for 4h; Inert atmosphere;99%
1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

benzoic acid
65-85-0

benzoic acid

2-benzoyloxypropiophenone
1030-23-5

2-benzoyloxypropiophenone

Conditions
ConditionsYield
Stage #1: 1-Phenyl-1-propanol; benzoic acid With N-Bromosuccinimide In 1,4-dioxane at 60℃; for 1h; Sealed tube;
Stage #2: With 1,8-diazabicyclo[5.4.0]undec-7-ene In 1,4-dioxane at 60℃; for 2h; Reagent/catalyst; Solvent; Temperature;
99%
Stage #1: 1-Phenyl-1-propanol; benzoic acid With N-Bromosuccinimide In 1,4-dioxane at 60℃; for 1h;
Stage #2: With 1,8-diazabicyclo[5.4.0]undec-7-ene In 1,4-dioxane for 2h;
99%
Stage #1: 1-Phenyl-1-propanol; benzoic acid With N-Bromosuccinimide In 1,4-dioxane at 60℃; for 1h;
Stage #2: With 1,8-diazabicyclo[5.4.0]undec-7-ene In 1,4-dioxane for 2h;
99%
With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide In water; ethyl acetate at 100℃; for 12h; Catalytic behavior; Reagent/catalyst; Solvent; Schlenk technique;72%
methanol
67-56-1

methanol

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

rac-2-methyl-1-phenylpropan-1-ol
611-69-8

rac-2-methyl-1-phenylpropan-1-ol

Conditions
ConditionsYield
With C24H24IrN4O4(1+)*BF4(1-); sodium t-butanolate at 140℃; for 24h; Sealed tube; Inert atmosphere;99%
With caesium carbonate at 150℃; for 24h;87%
With carbonylhydrido(tetrahydroborato)[bis(2-diphenylphosphinoethyl)amino]ruthenium(II); sodium methylate at 150℃; for 20h; Inert atmosphere; Autoclave; Glovebox; Green chemistry;83 %Spectr.
With trimethylamine-N-oxide; (1,4-dimethyl-5,7-diphenyl-1,2,3,4-tetrahydro-6H-cyclopenta[b]pyrazin-6-one) irontricarbonyl complex3; sodium hydroxide at 130℃; for 24h;12 %Spectr.
1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

benzoyl chloride
98-88-4

benzoyl chloride

(α-benzoyloxypropyl)benzene
58687-92-6

(α-benzoyloxypropyl)benzene

Conditions
ConditionsYield
With potassium hydroxide98.4%
With dmap; triethylamine In tetrahydrofuran; dichloromethane Heating;84%
1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

1,1,1,3,3,3-hexamethyl-disilazane
999-97-3

1,1,1,3,3,3-hexamethyl-disilazane

1-phenylpropyl trimethylsilyl ether
62559-30-2

1-phenylpropyl trimethylsilyl ether

Conditions
ConditionsYield
With polyvinylpolypyrrolidonium tribromide In acetonitrile at 20℃; for 0.116667h;98%
With L-Aspartic acid In acetonitrile at 20℃; for 0.0666667h;98%
With bismuth(lll) trifluoromethanesulfonate at 20℃; for 0.0333333h; Neat (no solvent);96%
1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

1-phenylpropyl-1-tosylate

1-phenylpropyl-1-tosylate

Conditions
ConditionsYield
With aluminum dodecatungstophosphate at 20℃; for 0.166667h;98%
succinic acid anhydride
108-30-5

succinic acid anhydride

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

3-((1-phenylpropyloxy)carbonyl)propanoic acid

3-((1-phenylpropyloxy)carbonyl)propanoic acid

Conditions
ConditionsYield
Stage #1: succinic acid anhydride; 1-Phenyl-1-propanol With dmap In dichloromethane at 20℃; for 2h; Inert atmosphere;
Stage #2: With hydrogenchloride In water
98%
With dmap In dichloromethane at 20℃; Inert atmosphere;
2-methylchlorobenzene
95-49-8

2-methylchlorobenzene

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

2-(2-methylphenyl)-1-phenylpropan-1-one
53423-27-1

2-(2-methylphenyl)-1-phenylpropan-1-one

Conditions
ConditionsYield
With allylchloro[1,3-bis(2,6-di-isopropylphenyl)imidazol-2-ylidine]palladium(II); potassium tert-butylate In toluene at 80℃; for 4h; Inert atmosphere;98%

1-Phenyl-1-propanol Chemical Properties

Molecular Formula:C9H12O
Molar mass:136.19098g/mol
Structure of 1-Phenyl-1-propanol(93-54-9):
                               
Synonyms of 1-Phenyl-1-propanol(93-54-9):.alpha.-Hydroxypropylbenzene;alpha-ethylbenzyl alcohol;1-Phenyl-1-propanol;Gallenperlen;Phenycholon;1-Phenyl-1-Hydroxypropane;1-Phenylpropan-1-ol;1-phenyl-propan-1-ol;1-Propanol, 1-phenyl-
Density:0.994 g/cm3                               
Flash Point:97.3 °C                    
Boiling Point:219 °C at 760 mmHg         
Index of Refraction:1.524               
Vapour Pressure:0.0707 mmHg at 25°C  
Water solubility:insoluble
Appearance:Colorless oily liquid

1-Phenyl-1-propanol Uses

1-Phenyl-1-propanol(93-54-9)  is also a gallbladder medicine,and can be used as a spice and heat-transfering medium.

1-Phenyl-1-propanol Production

Derived from the reduction of acetone from benzene in ethanol by potassium borohydride .

1-Phenyl-1-propanol Toxicity Data With Reference

1.   

orl-rat LD50:1600 mg/kg

   ARZNAD    Arzneimittel-Forschung. Drug Research. 12 (1962),347.
2.   

orl-mus LD50:500 mg/kg

   AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 116 (1958),154.
3.   

scu-mus LD50:700 mg/kg

   AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 116 (1958),154.
Carcinogenicity:1-Phenyl-1-propanol(93-54-9)- Not listed as a carcinogen by  NTP, IARC,ACGIH, or CA Prop 65. 
Other: See actual entry in RTECS for complete information.The toxicological properties have not been fully investigated. Mutagenicity: Ames-test: negative.

1-Phenyl-1-propanol Safety Profile

Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes:Xn
Risk Statements:
22:  Harmful if swallowed 
Safety Statements:
23:  Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer)
24:  Avoid contact with skin
25:  Avoid contact with eyes

1-Phenyl-1-propanol Specification

Stability and Reactivity of 1-Phenyl-1-propanol(93-54-9):
Conditions to Avoid:Incompatible materials. 
Chemical Stability:Stable under normal temperatures and pressures.
Incompatibilities with Other Materials:Incompatible materials, acid anhydrides, acid chlorides, acids.
Hazardous Decomposition Products: carbon dioxide,Carbon monoxide.
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