1-Phenylcyclopentylamine supplier

Name
1-Phenylcyclopentylamine
EINECS
CAS No. 17380-74-4
Article Data17
CAS DataBase
Density 1.014g/cm³
Solubility
Melting Point
Formula C₁₁ H₁₅ N
Boiling Point 253.2 °C at 760 mmHg
Molecular Weight 161.247
Flash Point 110 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Cyclopentylamine,1-phenyl- (7CI,8CI);1-Phenylcyclopentylamine;
PSA 26.02000
LogP 3.11490

Synthetic route

: 77-55-4
1-phenyl-1-cyclopentanecarboxylic acid

: 17380-74-4
1-phenylcyclopentylamine

Conditions

Conditions	Yield
Stage #1: 1-phenyl-1-cyclopentanecarboxylic acid With chloroformic acid ethyl ester; triethylamine In water; acetone at 0℃; for 0.5h; Stage #2: With sodium azide In water; acetone at 0℃; for 1h; Stage #3: With hydrogenchloride; tert-butyl alcohol more than 3 stages;	61%
Multi-step reaction with 2 steps 1: SOCl2 / dimethylformamide 2: (i) NaN3, xylene, (ii) aq. HCl View Scheme

: 77-55-4
1-phenyl-1-cyclopentanecarboxylic acid

: 1487-43-0
2-chloroethyl formate

: 17380-74-4
1-phenylcyclopentylamine

Conditions

Conditions	Yield
Stage #1: 1-phenyl-1-cyclopentanecarboxylic acid; 2-chloroethyl formate In water; acetone at 0℃; for 0.5h; Stage #2: With sodium azide In H20 at 0℃; for 1h; Stage #3: With hydrogenchloride; tert-butyl alcohol more than 3 stages;	61%

: 66021-70-3
1-(1-azidocyclopentyl)benzene

: 17380-74-4
1-phenylcyclopentylamine

Conditions

Conditions	Yield
With Raney nickel In isopropyl alcohol at 60 - 70℃;	40%
With lithium aluminium tetrahydride In diethyl ether for 3h; Yield given;
With lithium aluminium tetrahydride In diethyl ether at 20℃; for 3h; Inert atmosphere;
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 3h; Inert atmosphere;	291 mg

: 10487-96-4
1-phenylcyclopentanol

: 17380-74-4
1-phenylcyclopentylamine

Conditions

Conditions	Yield
(i) NaN3, CF3CO2H, CHCl3, (ii) Raney-Ni, iPrOH; Multistep reaction;
Multi-step reaction with 2 steps 1: NaN3, CF3COOH / CHCl3 / Ambient temperature 2: LiAlH4 / diethyl ether / 3 h View Scheme
Multi-step reaction with 2 steps 1: sodium azide; trifluoroacetic acid / dichloromethane / 1.25 h / -5 - 0 °C / Inert atmosphere 2: lithium aluminium tetrahydride / diethyl ether / 3 h / 20 °C / Inert atmosphere View Scheme
Multi-step reaction with 2 steps 1: trifluoroacetic acid; sodium azide / dichloromethane / 1 h / -5 - 0 °C / Inert atmosphere 2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere View Scheme
Multi-step reaction with 2 steps 1: sodium azide; trifluoroacetic acid / chloroform / 0 - 20 °C 2: Raney nickel / isopropyl alcohol / 60 - 70 °C View Scheme

: 17380-62-0
1-phenylcyclopentanecarboxylic acid chloride

: 17380-74-4
1-phenylcyclopentylamine

Conditions

Conditions	Yield
With sodium azide In toluene
(i) NaN3, xylene, (ii) aq. HCl; Multistep reaction;

: 17380-67-5
Methyl-(1-phenylcyclopentyl)-carbamat

: 17380-74-4
1-phenylcyclopentylamine

Conditions

Conditions	Yield
With potassium hydroxide In diethylene glycol

: phenylmagnesium bromide

: 17380-74-4
1-phenylcyclopentylamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: tetrahydrofuran / 0.33 h 2: NaN3, CF3COOH / CHCl3 / Ambient temperature 3: LiAlH4 / diethyl ether / 3 h View Scheme

: 120-92-3
cyclopentanone

: 17380-74-4
1-phenylcyclopentylamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: tetrahydrofuran / 0.33 h 2: NaN3, CF3COOH / CHCl3 / Ambient temperature 3: LiAlH4 / diethyl ether / 3 h View Scheme
Multi-step reaction with 3 steps 1.1: magnesium / tetrahydrofuran / 1.17 h / Cooling with ice; Reflux 1.2: 3 h / 0 - 20 °C 2.1: sodium azide; trifluoroacetic acid / dichloromethane / 1.25 h / -5 - 0 °C / Inert atmosphere 3.1: lithium aluminium tetrahydride / diethyl ether / 3 h / 20 °C / Inert atmosphere View Scheme
Multi-step reaction with 3 steps 1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 2: trifluoroacetic acid; sodium azide / dichloromethane / 1 h / -5 - 0 °C / Inert atmosphere 3: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere View Scheme

: 77-57-6
1-phenyl-1-cyclopentanecarbonitrile

: 17380-74-4
1-phenylcyclopentylamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: H2SO4 2: Br2 / methanol 3: KOH / bis-(2-hydroxy-ethyl) ether View Scheme
Multi-step reaction with 3 steps 1: KOH / bis-(2-hydroxy-ethyl) ether 2: SOCl2 / dimethylformamide 3: (i) NaN3, xylene, (ii) aq. HCl View Scheme

: 5296-89-9
1-phenylcyclopentane-1-carboxamide

: 17380-74-4
1-phenylcyclopentylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Br2 / methanol 2: KOH / bis-(2-hydroxy-ethyl) ether View Scheme

: 140-29-4
phenylacetonitrile

n-butyl halide: n-butyl halide

: 17380-74-4
1-phenylcyclopentylamine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: liq. NH3, NaNH2 2: KOH / bis-(2-hydroxy-ethyl) ether 3: SOCl2 / dimethylformamide 4: (i) NaN3, xylene, (ii) aq. HCl View Scheme

: 7647-01-0
hydrogenchloride

: 17380-74-4
1-phenylcyclopentylamine

Conditions

Conditions	Yield
Stage #1: C12H13N3O With tert-butyl alcohol In toluene for 12h; Heating / reflux; Stage #2: hydrogenchloride In water; toluene for 12h; Heating / reflux;

: 457077-86-0
C12H13N3O

: 17380-74-4
1-phenylcyclopentylamine

Conditions

Conditions	Yield
Stage #1: C12H13N3O With tert-butyl alcohol In toluene for 12h; Heating / reflux; Stage #2: With hydrogenchloride In water; toluene; tert-butyl alcohol for 12h; Heating / reflux; Stage #3: With sodium hydroxide at 0℃; pH=12;

: 1-phenyl-cyclopentyl isocyanate

: 17380-74-4
1-phenylcyclopentylamine

Conditions

Conditions	Yield
With sodium trimethylsilanolate In tetrahydrofuran; toluene at 0 - 20℃; for 0.333333h;

: 591-50-4
iodobenzene

: 17380-74-4
1-phenylcyclopentylamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: magnesium / tetrahydrofuran / 1.17 h / Cooling with ice; Reflux 1.2: 3 h / 0 - 20 °C 2.1: sodium azide; trifluoroacetic acid / dichloromethane / 1.25 h / -5 - 0 °C / Inert atmosphere 3.1: lithium aluminium tetrahydride / diethyl ether / 3 h / 20 °C / Inert atmosphere View Scheme

: 100-58-3
phenylmagnesium bromide

: 17380-74-4
1-phenylcyclopentylamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 2: trifluoroacetic acid; sodium azide / dichloromethane / 1 h / -5 - 0 °C / Inert atmosphere 3: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere View Scheme

: 17380-74-4
1-phenylcyclopentylamine

: 30084-90-3
9H-fluorene-2-carbaldehyde

: 75783-88-9
[1-(9H-Fluoren-2-yl)-meth-(Z)-ylidene]-(1-phenyl-cyclopentyl)-amine

Conditions

Conditions	Yield
In ethanol for 0.333333h; Heating;	90%

: 17380-74-4
1-phenylcyclopentylamine

: 4-hydroxy-3-[(4-methylpiperazin-1-yl)methyl]benzaldehyde

: 2-[(4-methylpiperazin-1-yl)methyl]-4-[[(1-phenylcyclopentyl)-amino]methyl]phenol

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride In dichloromethane at 20℃;	63%

: 941-55-9
4-toluenesulfonyl azide

: 17380-74-4
1-phenylcyclopentylamine

: C18H22N2O2S

Conditions

Conditions	Yield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; silver(I) triflimide In 1,2-dichloro-ethane at 100℃; Inert atmosphere; Sealed tube;	11%

: 108-55-4
glutaric anhydride,

: 17380-74-4
1-phenylcyclopentylamine

: 22904-86-5
N-(1-Phenylcyclopentyl)-glutarsaeureamid

Conditions

Conditions	Yield
at 180 - 200℃;

: 110-62-3
pentanal

: 17380-74-4
1-phenylcyclopentylamine

: Pent-(E)-ylidene-(1-phenyl-cyclopentyl)-amine

Conditions

Conditions	Yield
With potassium carbonate In benzene

: 17380-74-4
1-phenylcyclopentylamine

: 1,1'-Diphenylazocyclopentan

Conditions

Conditions	Yield
With pyridine; iodine pentafluoride In dichloromethane

: 17380-74-4
1-phenylcyclopentylamine

: 123-38-6
propionaldehyde

: (1-Phenyl-cyclopentyl)-prop-(E)-ylidene-amine

Conditions

Conditions	Yield
With potassium carbonate In benzene

: 17380-74-4
1-phenylcyclopentylamine

: 123-38-6
propionaldehyde

: 762-04-9
phosphonic acid diethyl ester

: [1-(1-Phenyl-cyclopentylamino)-propyl]-phosphonic acid diethyl ester

Conditions

Conditions	Yield
(i) K2CO3, benzene, (ii) /BRN= 605759/; Multistep reaction;

...Expand

: 17380-74-4
1-phenylcyclopentylamine

: 66-25-1
hexanal

: Hex-(E)-ylidene-(1-phenyl-cyclopentyl)-amine

Conditions

Conditions	Yield
With potassium carbonate In benzene

: 17380-74-4
1-phenylcyclopentylamine

: 66-25-1
hexanal

: 762-04-9
phosphonic acid diethyl ester

: [1-(1-Phenyl-cyclopentylamino)-hexyl]-phosphonic acid diethyl ester

Conditions

Conditions	Yield
(i) K2CO3, benzene, (ii) /BRN= 605759/; Multistep reaction;

...Expand

: 17380-74-4
1-phenylcyclopentylamine

: 1122-91-4
4-bromo-benzaldehyde

: 66824-10-0
[1-(4-Bromo-phenyl)-meth-(E)-ylidene]-(1-phenyl-cyclopentyl)-amine

Conditions

Conditions	Yield
With potassium carbonate In benzene
In methanol

: 17380-74-4
1-phenylcyclopentylamine

: 1122-91-4
4-bromo-benzaldehyde

: 762-04-9
phosphonic acid diethyl ester

: 66824-17-7
[(4-Bromo-phenyl)-(1-phenyl-cyclopentylamino)-methyl]-phosphonic acid diethyl ester

Conditions

Conditions	Yield
(i) K2CO3, benzene, (ii) /BRN= 605759/; Multistep reaction;

...Expand

: 110-62-3
pentanal

: 17380-74-4
1-phenylcyclopentylamine

: 762-04-9
phosphonic acid diethyl ester

: [1-(1-Phenyl-cyclopentylamino)-pentyl]-phosphonic acid diethyl ester

Conditions

Conditions	Yield
(i) K2CO3, benzene, (ii) /BRN= 605759/; Multistep reaction;

...Expand

: 17380-74-4
1-phenylcyclopentylamine

: 104-88-1
4-chlorobenzaldehyde

: 66824-08-6
[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-(1-phenyl-cyclopentyl)-amine

Conditions

Conditions	Yield
In methanol

: 17380-74-4
1-phenylcyclopentylamine

: 99-61-6
3-nitro-benzaldehyde

: 66824-12-2
[1-(3-Nitro-phenyl)-meth-(E)-ylidene]-(1-phenyl-cyclopentyl)-amine

Conditions

Conditions	Yield
In methanol

: 17380-74-4
1-phenylcyclopentylamine

: 555-16-8
4-nitrobenzaldehdye

: 66824-13-3
[1-(4-Nitro-phenyl)-meth-(E)-ylidene]-(1-phenyl-cyclopentyl)-amine

Conditions

Conditions	Yield
In methanol

: 17380-74-4
1-phenylcyclopentylamine

: 100-52-7
benzaldehyde

: 63207-61-4
(1-Phenyl-cyclopentyl)-[1-phenyl-meth-(E)-ylidene]-amine

Conditions

Conditions	Yield
In methanol

: 17380-74-4
1-phenylcyclopentylamine

: 529-20-4
2-methylphenyl aldehyde

: 66824-07-5
(1-Phenyl-cyclopentyl)-[1-o-tolyl-meth-(E)-ylidene]-amine

Conditions

Conditions	Yield
In methanol

: 17380-74-4
1-phenylcyclopentylamine

: 6287-38-3
3,4-dichlorobenzaldehyde

: 66824-09-7
[1-(3,4-Dichloro-phenyl)-meth-(E)-ylidene]-(1-phenyl-cyclopentyl)-amine

Conditions

Conditions	Yield
In methanol

: 17380-74-4
1-phenylcyclopentylamine

: 552-89-6
2-nitro-benzaldehyde

: 66824-11-1
[1-(2-Nitro-phenyl)-meth-(E)-ylidene]-(1-phenyl-cyclopentyl)-amine

Conditions

Conditions	Yield
In methanol

: 75-21-8
oxirane

: 17380-74-4
1-phenylcyclopentylamine

: 179096-81-2
2-(1-Phenyl-cyclopentylamino)-ethanol

Conditions

Conditions	Yield
With lithium perchlorate 1.) THF, 0 deg C, 10 min, 2.) THF, CH3CN, RT, 1.75 h; Yield given. Multistep reaction;

: 59661-86-8
2-phenylquinoline-4-carbonyl chloride

: 17380-74-4
1-phenylcyclopentylamine

: N-(1-phenylcyclopentyl)-2-phenylquinoline-4-carboxamide

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 24h; Ambient temperature;

1-Phenylcyclopentylamine Specification

The 1-Phenylcyclopentylamine with cas registry number of 17380-74-4, is also named Cyclopentylamine,1-phenyl- (7CI,8CI) ; 1-Phenylcyclopentylamine .

Physical properties of 1-Phenylcyclopentylamine : (1)ACD/LogP: 2.49; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.59; (4)ACD/LogD (pH 7.4): -0.01; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1.69; (9)#H bond acceptors: 1; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 3.24 Å²; (13)Index of Refraction: 1.554; (14)Molar Refractivity: 50.96 cm³; (15)Molar Volume: 158.9 cm³; (16)Polarizability: 20.2×10^-24cm³; (17)Surface Tension: 43.3 dyne/cm; (18)Enthalpy of Vaporization: 49.06 kJ/mol; (19)Vapour Pressure: 0.0185 mmHg at 25°C .

You can still convert the following datas into molecular structure: (1)SMILES:c1cc(ccc1)C2(N)CCCC2; (2)InChI:InChI=1/C11H15N/c12-11(8-4-5-9-11)10-6-2-1-3-7-10/h1-3,6-7H,4-5,8-9,12H2; (3)InChIKey:YXAQCAOJLDGGDZ-UHFFFAOYAR; (4)Std. InChI:InChI=1S/C11H15N/c12-11(8-4-5-9-11)10-6-2-1-3-7-10/h1-3,6-7H,4-5,8-9,12H2; (5)Std. InChIKey:YXAQCAOJLDGGDZ-UHFFFAOYSA-N .

Product Name

1-Phenylcyclopentylamine

Synthetic route

1-Phenylcyclopentylamine Specification

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