Product Name

  • Name

    17-Methyltestosterone

  • EINECS 200-366-3
  • CAS No. 58-18-4
  • Article Data57
  • CAS DataBase
  • Density 1.1 g/cm3
  • Solubility water: ≤0.5 mg/mL
  • Melting Point 162-168 °C(lit.)
  • Formula C20H30O2
  • Boiling Point 434.4 °C at 760 mmHg
  • Molecular Weight 302.457
  • Flash Point 185.3 °C
  • Transport Information
  • Appearance white to slightly yellowish-white crystalline
  • Safety 53-36/37-45-24/25-22
  • Risk Codes 45-63-22-20-19-11-61-60-36/37/38
  • Molecular Structure Molecular Structure of 58-18-4 (17-Methyltestosterone)
  • Hazard Symbols ToxicT,HarmfulXn,IrritantXi,FlammableF
  • Synonyms Androst-4-en-3-one,17b-hydroxy-17-methyl- (8CI);17a-Methyl-17b-hydroxyandrost-4-en-3-one;17a-Methyl-3-oxo-4-androsten-17b-ol;17a-Methyltestosterone;17b-Hydroxy-17a-methylandrost-4-ene-3-one;Android;Androsan;Androst-4-ene-17a-methyl-17b-ol-3-one;CDB 110;Glosso-Sterandryl;Homandren;Mesterone;Metandren;Oreton Methyl;Perandren;Steronyl;Synandrotabs;Testora;Testoviron (tablet);Testred;
  • PSA 37.30000
  • LogP 4.26930

Synthetic route

(8R,9S,10R,13S,14S,17S)-10,13,17-Trimethyl-17-(tetrahydro-furan-2-yloxy)-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
111222-36-7

(8R,9S,10R,13S,14S,17S)-10,13,17-Trimethyl-17-(tetrahydro-furan-2-yloxy)-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one

17-methyltestosterone
58-18-4

17-methyltestosterone

Conditions
ConditionsYield
With toluene-4-sulfonic acid In ethanol for 1h; Ambient temperature;100%
methylandrostenediol
521-10-8

methylandrostenediol

17-methyltestosterone
58-18-4

17-methyltestosterone

Conditions
ConditionsYield
With <(C4Ph4COHOCC4Ph4)(μ-H)><(CO)4Ru2>; acetone at 56℃; for 18h;93%
With chromium(VI) oxide; bromine; acetic acid Behandeln des Reaktionsprodukts mit CrCl2 in wss.Methanol unter Kohlendioxyd;
With aluminum tri-tert-butoxide; acetone; benzene
C22H34O2

C22H34O2

17-methyltestosterone
58-18-4

17-methyltestosterone

Conditions
ConditionsYield
With hydrogenchloride In water; toluene at 60 - 65℃; Solvent; Reagent/catalyst;81.6%
Conditions
ConditionsYield
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In dimethyl sulfoxide at 65℃; for 24h;A 10%
B 74%
With 1-n-butyl-3-methylimidazolim bromide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione at 65℃; for 22h;A 10%
B 74%
metandienone
72-63-9

metandienone

17-methyltestosterone
58-18-4

17-methyltestosterone

Conditions
ConditionsYield
With thallium(III) nitrate trihydrate In diethylene glycol dimethyl ether for 24h; Ambient temperature;34%
pyridine
110-86-1

pyridine

methylandrostenediol
521-10-8

methylandrostenediol

trityl chloride
76-83-5

trityl chloride

17-methyltestosterone
58-18-4

17-methyltestosterone

Conditions
ConditionsYield
Erhitzen des Reaktionsprodukts mit Kupfer-Spaenen unter vermindertem Druck auf 250-300grad;
3-ethoxyandrosta-3,5-dien-17-one
972-46-3

3-ethoxyandrosta-3,5-dien-17-one

methylmagnesium bromide
75-16-1

methylmagnesium bromide

17-methyltestosterone
58-18-4

17-methyltestosterone

Conditions
ConditionsYield
With diethyl ether; toluene anschliessend Behandeln mit wss.NH4Cl und Behandeln des Reaktionsprodukts mit wss.Saeure;
methylandrostenediol
521-10-8

methylandrostenediol

cyclohexanone
108-94-1

cyclohexanone

17-methyltestosterone
58-18-4

17-methyltestosterone

Conditions
ConditionsYield
With aluminum isopropoxide; toluene
methylandrostenediol
521-10-8

methylandrostenediol

cyclohexanone
108-94-1

cyclohexanone

aluminum isopropoxide
555-31-7

aluminum isopropoxide

toluene
108-88-3

toluene

17-methyltestosterone
58-18-4

17-methyltestosterone

methylandrostenediol
521-10-8

methylandrostenediol

trityl chloride
76-83-5

trityl chloride

17-methyltestosterone
58-18-4

17-methyltestosterone

Conditions
ConditionsYield
With pyridine Erhitzen des Reaktionsprodukts mit Kupfer-Spaenen unter vermindertem Druck auf 250-300grad;
With pyridine Erhitzen des Reaktionsprodukts mit Kupfer-Spaenen unter vermindertem Druck auf 250-300grad;
methylandrostenediol
521-10-8

methylandrostenediol

aluminum isopropoxide
555-31-7

aluminum isopropoxide

acetone
67-64-1

acetone

benzene
71-43-2

benzene

17-methyltestosterone
58-18-4

17-methyltestosterone

methylandrostenediol
521-10-8

methylandrostenediol

aluminum tri-tert-butoxide
556-91-2

aluminum tri-tert-butoxide

acetone
67-64-1

acetone

benzene
71-43-2

benzene

17-methyltestosterone
58-18-4

17-methyltestosterone

methylmagnesium bromide
75-16-1

methylmagnesium bromide

3.3-ethylenedioxy-androsten-(4)-one-(17)

3.3-ethylenedioxy-androsten-(4)-one-(17)

17-methyltestosterone
58-18-4

17-methyltestosterone

Conditions
ConditionsYield
With diethyl ether; toluene anschliessend mit wss.NH4Cl und Behandeln des Reaktionsprodukts mit wss.Saeure;
methylandrostenediol
521-10-8

methylandrostenediol

bromine
7726-95-6

bromine

acetic acid
64-19-7

acetic acid

CrO3

CrO3

17-methyltestosterone
58-18-4

17-methyltestosterone

Conditions
ConditionsYield
Behandeln des Reaktionsprodukts mit wss.-methanol. CrCl2-Loesung unter Kohlendioxyd;
Behandeln des Reaktionsprodukts in Aethanol und Benzol oder in Eisessig mit Zink-Pulver;
Behandeln des Reaktionsprodukts in Aethanol und Benzol oder in Eisessig mit Zink-Pulver;
methylandrostenediol
521-10-8

methylandrostenediol

acetone
67-64-1

acetone

benzene
71-43-2

benzene

magnesium chloride tert-butylate

magnesium chloride tert-butylate

17-methyltestosterone
58-18-4

17-methyltestosterone

17β-hydroxy-17α-methylandrost-4-ene
5225-36-5

17β-hydroxy-17α-methylandrost-4-ene

acetic acid
64-19-7

acetic acid

CrO3

CrO3

17-methyltestosterone
58-18-4

17-methyltestosterone

dehydroepiandrosterone
53-43-0

dehydroepiandrosterone

17-methyltestosterone
58-18-4

17-methyltestosterone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diethyl ether
2: bromine; acetic acid; CrO3 / Behandeln von Loesungen des Reaktionsprodukts in Aethanol und Benzol oder in Essigsaeure mit Zink-Pulver
View Scheme
Multi-step reaction with 2 steps
1: diethyl ether
2: bromine; acetic acid; CrO3 / Behandeln des Reaktionsprodukts mit CrCl2 in wss.Methanol unter Kohlendioxyd
View Scheme
Progesterone
57-83-0

Progesterone

A

16-dehydroprogesterone
1096-38-4

16-dehydroprogesterone

B

17-methyltestosterone
58-18-4

17-methyltestosterone

C

Pregnenolone
145-13-1

Pregnenolone

D

21-Hydroxyprogesterone
64-85-7

21-Hydroxyprogesterone

E

pregna-4,7-diene-3,20-dione
17398-60-6

pregna-4,7-diene-3,20-dione

F

pregnane-3,6,20-trione
30802-24-5

pregnane-3,6,20-trione

G

pregnane-3,20-dione
7350-00-7

pregnane-3,20-dione

Conditions
ConditionsYield
With Hortaea werneckii B-763 at all growth phases In YNB growth medium; N,N-dimethyl-formamide at 28℃; for 24h; Enzymatic reaction;
Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

C22H36O3

C22H36O3

17-methyltestosterone
58-18-4

17-methyltestosterone

Conditions
ConditionsYield
Stage #1: Chlorodifluoromethane With iodine; triethylamine In tetrahydrofuran at 40 - 45℃; for 1h;
Stage #2: C22H36O3 In tetrahydrofuran; toluene at 1 - 45℃; for 24h;
33.9 g
C23H33NO3

C23H33NO3

17-methyltestosterone
58-18-4

17-methyltestosterone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridine; trichlorophosphate / N,N-dimethyl-formamide
2: sodium hydroxide; sodium tetrahydroborate
3: manganese(IV) oxide
View Scheme
chloroform
67-66-3

chloroform

3,17-dihydroxy-5-androstene
14504-94-0

3,17-dihydroxy-5-androstene

17-methyltestosterone
58-18-4

17-methyltestosterone

Conditions
ConditionsYield
With manganese(IV) oxide
3-acetyloxypregna-5,16-diene-20-one
38521-84-5

3-acetyloxypregna-5,16-diene-20-one

17-methyltestosterone
58-18-4

17-methyltestosterone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydroxylamine hydrochloride
2: pyridine; trichlorophosphate / N,N-dimethyl-formamide
3: sodium hydroxide; sodium tetrahydroborate
4: manganese(IV) oxide
View Scheme
Androstenedione
63-05-8

Androstenedione

17-methyltestosterone
58-18-4

17-methyltestosterone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogenchloride / ethanol / 20 - 25 °C
2.1: magnesium / tetrahydrofuran / 45 - 50 °C
2.2: 50 - 55 °C
3.1: hydrogenchloride / toluene; water / 60 - 65 °C
View Scheme
Multi-step reaction with 3 steps
1.1: hydrogenchloride / ethanol / 20 - 25 °C
2.1: magnesium / diethyl ether / 35 - 40 °C
2.2: 50 - 55 °C
3.1: hydrogenchloride / toluene; water / 60 - 65 °C
View Scheme
3-ethoxyandrosta-3,5-dien-17-one
972-46-3

3-ethoxyandrosta-3,5-dien-17-one

17-methyltestosterone
58-18-4

17-methyltestosterone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: magnesium / tetrahydrofuran / 45 - 50 °C
1.2: 50 - 55 °C
2.1: hydrogenchloride / toluene; water / 60 - 65 °C
View Scheme
tetrahydrofuran
109-99-9

tetrahydrofuran

17-methyltestosterone
58-18-4

17-methyltestosterone

(8R,9S,10R,13S,14S,17S)-10,13,17-Trimethyl-17-(tetrahydro-furan-2-yloxy)-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
111222-36-7

(8R,9S,10R,13S,14S,17S)-10,13,17-Trimethyl-17-(tetrahydro-furan-2-yloxy)-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one

Conditions
ConditionsYield
With tetrachloromethane; manganese at 65℃; for 8h;91%
With ceric triethylammonium nitrate In toluene at 100℃; for 8h;40%
17-methyltestosterone
58-18-4

17-methyltestosterone

2,17beta-Dihydroxy-17-methylandrosta-1,4-dien-3-one
2304-17-8

2,17beta-Dihydroxy-17-methylandrosta-1,4-dien-3-one

Conditions
ConditionsYield
With 18-crown-6 ether; potassium tert-butylate; oxygen In toluene at -25℃; for 4h;91%
17-methyltestosterone
58-18-4

17-methyltestosterone

17β-hydroxy-17α-methyl-3,5-seco-4-nor-5-oxo-androstan-3-oic acid
2931-65-9

17β-hydroxy-17α-methyl-3,5-seco-4-nor-5-oxo-androstan-3-oic acid

Conditions
ConditionsYield
With ozone at -31 - -29℃; for 1.5h; Inert atmosphere;87%
With acetic acid Ozonolyse;
With ruthenium(IV) oxide; sodium periodate In tetrachloromethane; water; acetone for 0.5h;10.96 g
17-methyltestosterone
58-18-4

17-methyltestosterone

A

(1R,8S,9S,10R,13S,14S,17S)-1,17-Dihydroxy-10,13,17-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-2-oxa-cyclopenta[a]phenanthren-3-one
138513-20-9

(1R,8S,9S,10R,13S,14S,17S)-1,17-Dihydroxy-10,13,17-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-2-oxa-cyclopenta[a]phenanthren-3-one

B

(1S,8S,9S,10R,13S,14S,17S)-1,17-Dihydroxy-10,13,17-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-2-oxa-cyclopenta[a]phenanthren-3-one
110716-65-9

(1S,8S,9S,10R,13S,14S,17S)-1,17-Dihydroxy-10,13,17-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-2-oxa-cyclopenta[a]phenanthren-3-one

Conditions
ConditionsYield
With crown ether; potassium tert-butylate; oxygen In toluene 1.) -25 deg C, 1.5-4 h, 2.) room temperature, 3 d; Title compound not separated from byproducts;A n/a
B 85%
17-methyltestosterone
58-18-4

17-methyltestosterone

ethylene glycol
107-21-1

ethylene glycol

3,3-(ethylenedioxy)-17α-methyl-5-androsten-17β-ol
1099-72-5

3,3-(ethylenedioxy)-17α-methyl-5-androsten-17β-ol

Conditions
ConditionsYield
With toluene-4-sulfonic acid In benzene for 4.5h; Heating;82%
With toluene-4-sulfonic acid; benzene
With boron trifluoride diethyl etherate; orthoformic acid triethyl ester In chloroform at 30 - 35℃; for 9h; Solvent;22.3 g
17-methyltestosterone
58-18-4

17-methyltestosterone

metandienone
72-63-9

metandienone

Conditions
ConditionsYield
With tert-butyldimethylsilyl chloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone In 1,4-dioxane at 0 - 20℃; for 48h;78%
With selenium(IV) oxide
mit Hilfe von Didymella lycopersici;
17-methyltestosterone
58-18-4

17-methyltestosterone

6-Ketomethyltestosterone
96992-13-1

6-Ketomethyltestosterone

Conditions
ConditionsYield
With potassium hydroxide; tetrazolium blue In ethanol Heating;73%
Multi-step reaction with 2 steps
1: mit Hilfe von Rhizopus nigricans
2: CrO3; acetic acid
View Scheme
17-methyltestosterone
58-18-4

17-methyltestosterone

17,17-dimethyl-18-norandrosta-4,13(14)-dien-3-one
1971-59-1

17,17-dimethyl-18-norandrosta-4,13(14)-dien-3-one

Conditions
ConditionsYield
With hydrogenchloride at 60℃; for 0.5h;65%
With N-(2-chloro-1,1,2-trifluoroethyl)diethylamine In acetonitrile
With hydrogenchloride In methanol Heating;
With hydrogenchloride
With hydrogenchloride; acetic acid
17-methyltestosterone
58-18-4

17-methyltestosterone

A

15α-hydroxy-17α-methyltestosterone

15α-hydroxy-17α-methyltestosterone

B

15α,17β-dihydroxy-17α-methyl-5α-androstan-3-one

15α,17β-dihydroxy-17α-methyl-5α-androstan-3-one

Conditions
ConditionsYield
With Penicillium notatum KCH 904 In water; acetone at 27℃; for 312h; Enzymatic reaction;A 65%
B 31%
17-methyltestosterone
58-18-4

17-methyltestosterone

androsta-3,5-dien-17β-ol, 17-methyl-

androsta-3,5-dien-17β-ol, 17-methyl-

Conditions
ConditionsYield
Stage #1: 17-methyltestosterone With C19H26ClIrN3O(1+)*Cl(1-) In water; acetonitrile at 80℃; for 0.166667h; Green chemistry;
Stage #2: With formic acid In water; acetonitrile at 80℃; for 2h; Green chemistry;
63%
(i) LiAlH4, THF, (ii) aq. HCl, acetone; Multistep reaction;
formaldehyde diethyl acetal
462-95-3

formaldehyde diethyl acetal

17-methyltestosterone
58-18-4

17-methyltestosterone

17β-hydroxy-17α-methyl-6-methyleneandrost-4-en-3-one
80126-38-1

17β-hydroxy-17α-methyl-6-methyleneandrost-4-en-3-one

Conditions
ConditionsYield
With sodium acetate; trichlorophosphate In chloroform for 1h; Heating;51%
With sodium acetate; trichlorophosphate In chloroform
17-methyltestosterone
58-18-4

17-methyltestosterone

Propargylamine
2450-71-7

Propargylamine

A

17α-methyl-17β-hydroxy-5-ene-androst-3-eno[3,4-b]pyridine

17α-methyl-17β-hydroxy-5-ene-androst-3-eno[3,4-b]pyridine

B

C23H33NO

C23H33NO

Conditions
ConditionsYield
With copper(II) nitrate In ethanol for 12h; Heating;A 47%
B 6%
17-methyltestosterone
58-18-4

17-methyltestosterone

A

15α-hydroxy-17α-methyltestosterone

15α-hydroxy-17α-methyltestosterone

B

11α,17β-Dihydroxy-17α-methylandrost-4-en-3-one
1807-02-9

11α,17β-Dihydroxy-17α-methylandrost-4-en-3-one

C

7α,17β-dihydroxy-17-methyl-4-androsten-3-one
972-50-9

7α,17β-dihydroxy-17-methyl-4-androsten-3-one

Conditions
ConditionsYield
With D-glucose In water; acetone at 25℃; Reagent/catalyst; Microbiological reaction;A 19%
B 17%
C 45%
17-methyltestosterone
58-18-4

17-methyltestosterone

A

15α-hydroxy-17α-methyltestosterone

15α-hydroxy-17α-methyltestosterone

B

12β-hydroxy-17α-methyltestosterone

12β-hydroxy-17α-methyltestosterone

C

11α,17β-Dihydroxy-17α-methylandrost-4-en-3-one
1807-02-9

11α,17β-Dihydroxy-17α-methylandrost-4-en-3-one

D

6β,17β-dihydroxy-17α-methylandrost-4-en-3-one
13096-49-6

6β,17β-dihydroxy-17α-methylandrost-4-en-3-one

E

15β-hydroxy-17α-methyltestosterone

15β-hydroxy-17α-methyltestosterone

F

7α,17β-dihydroxy-17-methyl-4-androsten-3-one
972-50-9

7α,17β-dihydroxy-17-methyl-4-androsten-3-one

Conditions
ConditionsYield
With D-glucose In water; acetone at 25℃; Reagent/catalyst; Microbiological reaction;A 9%
B 29%
C 5%
D 34%
E 4%
F 6%
17-methyltestosterone
58-18-4

17-methyltestosterone

A

15α-hydroxy-17α-methyltestosterone

15α-hydroxy-17α-methyltestosterone

B

11α,17β-Dihydroxy-17α-methylandrost-4-en-3-one
1807-02-9

11α,17β-Dihydroxy-17α-methylandrost-4-en-3-one

C

6β,17β-dihydroxy-17α-methylandrost-4-en-3-one
13096-49-6

6β,17β-dihydroxy-17α-methylandrost-4-en-3-one

D

14α-hydroxy-17α-methyltestosterone

14α-hydroxy-17α-methyltestosterone

E

6β,14α-dihydroxy-17α-methyltestosterone

6β,14α-dihydroxy-17α-methyltestosterone

F

9α-hydroxy-17α-methyltestosterone

9α-hydroxy-17α-methyltestosterone

G

7α,17β-dihydroxy-17-methyl-4-androsten-3-one
972-50-9

7α,17β-dihydroxy-17-methyl-4-androsten-3-one

Conditions
ConditionsYield
With D-glucose In water; acetone at 25℃; Reagent/catalyst; Microbiological reaction;A 31%
B 20%
C 7%
D 7%
E 4%
F 5%
G 16%
17-methyltestosterone
58-18-4

17-methyltestosterone

A

17-methyl-estra-1,3,5(10)-triene-3,17α-diol
302-76-1

17-methyl-estra-1,3,5(10)-triene-3,17α-diol

B

6β,12β-dihydroxy-17α-methyltestosterone

6β,12β-dihydroxy-17α-methyltestosterone

C

7β-hydroxy-17α-methyltestosterone

7β-hydroxy-17α-methyltestosterone

D

6β,17β-dihydroxy-17α-methylandrost-4-en-3-one
13096-49-6

6β,17β-dihydroxy-17α-methylandrost-4-en-3-one

E

6β,17β-dihydroxy-17α-methyl-1,4-androstadien-3-one
33526-41-9

6β,17β-dihydroxy-17α-methyl-1,4-androstadien-3-one

Conditions
ConditionsYield
With Acremonium strictum PTCC 5282 strain at 25℃; for 144h; pH=6.5; Enzymatic reaction;A 7.6%
B 24.3%
C 16.7%
D 28.4%
E 9.5%
17-methyltestosterone
58-18-4

17-methyltestosterone

A

6β,17β-dihydroxy-17α-methylandrost-4-en-3-one
13096-49-6

6β,17β-dihydroxy-17α-methylandrost-4-en-3-one

B

6β,11α,17β-trihydroxy-17α-methylandrost-4-en-3-one

6β,11α,17β-trihydroxy-17α-methylandrost-4-en-3-one

Conditions
ConditionsYield
With fungus Cephalosporium aphidicola In ethanol for 120h; hydroxylation;A 17%
B 4%
17-methyltestosterone
58-18-4

17-methyltestosterone

UDP-glucuronic acid
2616-64-0

UDP-glucuronic acid

A

17α-methyl-5β-androstane-3α-ol-17β-O-glucuronide

17α-methyl-5β-androstane-3α-ol-17β-O-glucuronide

B

17α-methyl-5α-androstane-17β-ol-3α-O-glucuronide

17α-methyl-5α-androstane-17β-ol-3α-O-glucuronide

C

17α-methyl-5β-androstane-17β-ol-3α-O-glucuronide

17α-methyl-5β-androstane-17β-ol-3α-O-glucuronide

Conditions
ConditionsYield
With liver microsomes from Aroclor 1254-induced male Wistar rat In methanol; phosphate buffer at 37℃; pH=7.4;A 14%
B n/a
C n/a
17-methyltestosterone
58-18-4

17-methyltestosterone

17-Methyl-13,17-seco-androst-4-en-3,17-dion

17-Methyl-13,17-seco-androst-4-en-3,17-dion

Conditions
ConditionsYield
With silica gel for 46h; Irradiation;7.9%
17-methyltestosterone
58-18-4

17-methyltestosterone

A

C40H58O3

C40H58O3

B

C40H58O3

C40H58O3

Conditions
ConditionsYield
for 4h; Irradiation;A 1%
B 5%
pyrrolidine
123-75-1

pyrrolidine

17-methyltestosterone
58-18-4

17-methyltestosterone

17α-methyl-3-pyrrolidino-androsta-3,5-dien-17β-ol
95908-76-2

17α-methyl-3-pyrrolidino-androsta-3,5-dien-17β-ol

Conditions
ConditionsYield
With benzene
isoniazid
54-85-3

isoniazid

17-methyltestosterone
58-18-4

17-methyltestosterone

17β-hydroxy-17α-methyl-androst-4-en-3-one-isonicotinoylhydrazone
6180-04-7

17β-hydroxy-17α-methyl-androst-4-en-3-one-isonicotinoylhydrazone

17-methyltestosterone
58-18-4

17-methyltestosterone

17-Methylene-4-androstene-3-one
846-45-7

17-Methylene-4-androstene-3-one

Conditions
ConditionsYield
With copper(II) sulfate at 135 - 150℃; under 0.01 Torr;

17-Methyltestosterone Chemical Properties

IUPAC Name: (8R,9S,10R,13S,14S,17S)-17-Hydroxy-10,13,17-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Molecular Structure:
Molecular Formula : C20H30O2
Molecular Weight : 302.45
CAS NO: 58-18-4
EINECS : 200-366-3
Index of Refraction: 1.556
Surface Tension: 43.7 dyne/cm
Density: 1.1 g/cm3
Flash Point: 185.3 °C
Enthalpy of Vaporization: 79.71 kJ/mol
Boiling Point: 434.4 °C at 760 mmHg
Vapour Pressure: 2.28E-09 mmHg at 25 °C
Melting point 162-168 &dec;C
Alpha : 79 º (c=1, alcohol)
Storage temp: 2-8 °C
Solubility H2O: ≤0.5 mg/mL 
Appearance: Methyltestosterone (CAS NO. 58-18-4) is white to slightly yellowish-white crystalline .
Classification Code of Methyltestosterone (CAS NO. 58-18-4): Anabolic Agents; Androgen; Antineoplastic Agents; Antineoplastic agents, hormonal; Drug / Therapeutic Agent; Hormone; Hormones; Hormones, Hormone Substitutes, and Hormone Antagonists; Human Data; Mutation data; Reproductive Effect; Tumor data

17-Methyltestosterone Uses

1.Methyltestosterone (CAS NO. 58-18-4) is used for androgen medicines, used for supplement treatment with testosterone deficiency .
2.Methyltestosterone (CAS NO. 58-18-4) can also be used for functional bleeding of uterine, aplastic anemia and other diseases treatment.

17-Methyltestosterone Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 39mg/kg/33W-I (39mg/kg) LIVER: "JAUNDICE, CHOLESTATIC" American Journal of Gastroenterology. Vol. 82, Pg. 461, 1987.
mouse LD50 intraperitoneal 400mg/kg (400mg/kg)   Drugs in Japan Vol. 6, Pg. 830, 1982.
mouse LD50 oral 1860mg/kg (1860mg/kg)   Drugs in Japan Vol. 6, Pg. 830, 1982.
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. 6, Pg. 830, 1982.
rat LD50 intraperitoneal 1050mg/kg (1050mg/kg)   Drugs in Japan Vol. 6, Pg. 830, 1982.
rat LD50 oral 2500mg/kg (2500mg/kg)   Drugs in Japan Vol. 6, Pg. 830, 1982.
rat LD50 subcutaneous 5gm/kg (5000mg/kg)   Drugs in Japan Vol. 6, Pg. 830, 1982.

17-Methyltestosterone Safety Profile

Hazard Codes: ToxicT,HarmfulXn,IrritantXi ,F
Risk Statements: 45-63-22-20-19-11-61-60-36/37/38 
R45:May cause cancer. 
R63:Possible risk of harm to the unborn child. 
R22:Harmful if swallowed. 
R20:Harmful by inhalation. 
R19:May form explosive peroxides. 
R11:Highly flammable. 
R60:May impair fertility. 
R61:May cause harm to the unborn child. 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 53-36/37-45-24/25-22 
S53:Avoid exposure - obtain special instructions before use. 
S36/37:Wear suitable protective clothing and gloves. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S24/25:Avoid contact with skin and eyes. 
S22:Do not breathe dust.
RIDADR: 3249
WGK Germany: 3
RTECS: BV8400000
HazardClass: 6.1(b)
PackingGroup: III

17-Methyltestosterone Specification

 Methyltestosterone (CAS NO. 58-18-4), its Synonyms are (17-beta)-17-Hydroxy-17-methylandrost-4-en-3-one ; 17(alpha)-Methyl-delta4-androsten-17(beta)-ol-3-one ; 17-Hydroxy-17-methyl-3-keto-androstene-4 ; 17-beta-Hydroxy-17-methylandrost-4-en-3-one ; 17alpha-Methyl-3-oxo-4-androsten-17beta-ol ; 17alpha-Methyl-delta-androsten-17beta-ol-3-one ; M.T.Mucorettes ; Malestrone ; Androst-4-en-3-one, 17-beta-hydroxy-17-methyl- ; Androst-4-en-3-one, 17-hydroxy-17-methyl-, (17beta)- ; Androst-4-en-3-one, 17beta-hydroxy-17-methyl- .

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