2'-Deoxyuridine supplier | CasNO.951-78-0

Name
2'-Deoxyuridine
EINECS 213-455-7
CAS No. 951-78-0
Article Data90
CAS DataBase
Density 1.533 g/cm³
Solubility 300 g/L at 20°C in water
Melting Point 167-169 °C(lit.)
Formula C₉H₁₂N₂O₅
Boiling Point 370.01°C (rough estimate)
Molecular Weight 228.205
Flash Point
Transport Information
Appearance White crystalline powder
Safety 22-24/25-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms 1-(2-Deoxy-b-D-erythro-pentofuranosyl)uracil;2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-b-D-erythro-pentofuranosyl)-;2,4(1H,3H)-Pyrimidinedione,1-(2-deoxy-b-D-ribofuranosyl)-;2'-Desoxyuridine;Deoxyribose uracil;Deoxyuridine;NSC 23615;Uracildeoxyriboside;1-(2-Deoxy-b-D-ribofuranosyl)uracil;1-(2-Deoxy-D-erythro-pentofuranosyl)uracil;Uridine, 2'-deoxy-;
PSA 104.55000
LogP -1.82270

Synthetic route

: 14270-73-6
O5'-trityl-2'-deoxy-uridine

: 951-78-0
2'-deoxyuridine

Conditions

Conditions	Yield
With silica gel; trifluoroacetic acid In methanol; chloroform	100%

: 951-77-9
2'-Deoxycytidine

: 951-78-0
2'-deoxyuridine

Conditions

Conditions	Yield
With cytidine deaminase enzyme In aq. phosphate buffer at 37℃; for 0.0833333h; pH=7; Enzymatic reaction;	99%
With acetic acid; sodium nitrite
With sodium hydroxide at 90.1℃; Rate constant; Mechanism; various reagent concentration, decomposition to nonchromophoric products;

: 130197-82-9
4-O-(2,4,6-Trimethylphenyl)-2'-deoxyuridine

A: 951-78-0
2'-deoxyuridine

B: 951-77-9
2'-Deoxycytidine

Conditions

Conditions	Yield
With ammonium hydroxide at 65℃; for 2h;	A n/a B 98%

: 59-14-3
5-bromo-2'-deoxyuridine

: 951-78-0
2'-deoxyuridine

Conditions

Conditions	Yield
With triethylamine In methanol; water at 4℃; for 12h; Irradiation; sensitizer: methylene blue;	96%
Multi-step reaction with 3 steps 1: 99.7 percent / p-toluenesulfonic acid / tetrahydrofuran / 2 h / Ambient temperature 2: n-BuLi, MeI / tetrahydrofuran; hexane / -78 °C 3: 1N HCl / methanol / 0.08 h / Heating View Scheme
Multi-step reaction with 2 steps 1: (NH4)2SO4 / Heating 2: 1) PdCl3, Ph3P, 2) NH4Cl, H2O / 1) THF, reflux, 12 h, 2) MeOH, reflux, 3 h View Scheme
With sodium tetrahydroborate; Naphthalene-1,8-diselenol In aq. phosphate buffer at 37℃; pH=7; Reagent/catalyst;
With sodium tetrahydroborate; C10H8Te In aq. phosphate buffer at 37℃; pH=7; Kinetics; Reagent/catalyst;

: 64911-18-8
3',5'-O-di(tert-butyldimethylsilyl)-2'-deoxyuridine

: 951-78-0
2'-deoxyuridine

Conditions

Conditions	Yield
With K 10 clay In methanol; water at 75℃; for 12h;	94%

: 98495-56-8
3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyuridine

: 951-78-0
2'-deoxyuridine

Conditions

Conditions	Yield
With K 10 clay In methanol; water at 75℃; for 60h;	90%
With tetrabutyl ammonium fluoride Yield given;

: 66-22-8
uracil

: 7-methyl-2′-deoxyguanosine hydroiodide

: 951-78-0
2'-deoxyuridine

Conditions

Conditions	Yield
With potassium dihydrogenphosphate; Escherichia coli thymidine phosphorylase; Escherichia coli purine nucleoside phosphorylase In aq. buffer at 20℃; for 20h; pH=7.5; Enzymatic reaction;	80%

: 629-45-8
dibutyl disulfide

: 65505-76-2
C5-chloromercuri-2'-deoxyuridine

A: 951-78-0
2'-deoxyuridine

B: 21740-34-1
5-(1-Thiapentyl)-2'-deoxyuridine

Conditions

Conditions	Yield
With lithium tetrachloropalladate(II) In methanol for 16h; Ambient temperature;	A n/a B 73%
With lithium tetrachloropalladate(II) In methanol for 16h; Ambient temperature; other organic disulfides;	A n/a B 73%

...Expand

: 1140622-65-6
3'-O-acetyl-5'-O-t-butyldimethylsilyl-2'-deoxyuridine

: 100-51-6
benzyl alcohol

A: 53172-91-1
(benzyloxy)(tert-butyl)dimethylsilane

B: 951-78-0
2'-deoxyuridine

C: 66-22-8
uracil

D: 23197-88-8
3'-O-acetyl-2'-deoxyuridine

Conditions

Conditions	Yield
With copper(II) sulfate In xylene for 2h; Heating;	A n/a B n/a C n/a D 72%

...Expand

: 58-96-8
uridine

: 951-78-0
2'-deoxyuridine

Conditions

Conditions	Yield
Multistep reaction;	60%
Multi-step reaction with 4 steps 1: 90 percent / pyridine / 2 h / Ambient temperature 2: 4-(dimethylamino)pyridine / acetonitrile / 6 h / Ambient temperature 3: tri-n-butylstannane, α,α'-azoisobutyronitrile / toluene / 3 h / 75 °C 4: tetra-n-butylammonium fluoride View Scheme
Multi-step reaction with 3 steps 1: sodium hydroxide; bis(phenyl) carbonate / N,N-dimethyl-formamide / 12 h / 140 °C 2: hydrogenchloride / N,N-dimethyl-formamide / 14 h / 40 °C 3: sodium hydroxide; nickel; hydrogen / methanol / 20 h / 40 °C View Scheme

: 64911-18-8
3',5'-O-di(tert-butyldimethylsilyl)-2'-deoxyuridine

: 100-51-6
benzyl alcohol

A: 53172-91-1
(benzyloxy)(tert-butyl)dimethylsilane

B: 951-78-0
2'-deoxyuridine

C: 65-71-4
thymin

Conditions

Conditions	Yield
With copper(II) sulfate In xylene Heating;	A 0.92 g B 53% C n/a

...Expand

: 65505-76-2
C5-chloromercuri-2'-deoxyuridine

: 882-33-7
diphenyldisulfane

A: 951-78-0
2'-deoxyuridine

B: 100634-97-7
5-phenylsulfanyl-2'-deoxyuridine

Conditions

Conditions	Yield
With lithium tetrachloropalladate(II) In methanol for 16h; Ambient temperature;	A n/a B 52%

...Expand

: 65505-76-2
C5-chloromercuri-2'-deoxyuridine

: 118042-46-9
N,N'-Bis(trifluoroacetyl)cystamine

A: 951-78-0
2'-deoxyuridine

B: 118042-45-8
5-<3-(Trifluoroacetamido)-1-thiapropyl>-2'-deoxyuridine

Conditions

Conditions	Yield
With lithium tetrachloropalladate(II) In methanol for 16h; Ambient temperature;	A n/a B 51%

...Expand

: 54-42-2
5-Iodo-2'-deoxyuridine

: 762-72-1
allyl-trimethyl-silane

A: 951-78-0
2'-deoxyuridine

B: 73-39-2
C5-(allyl)-2'-deoxyuridine

Conditions

Conditions	Yield
In water; acetonitrile Irradiation;	A 31% B 49%
In water; acetonitrile for 10h; Ambient temperature; Irradiation;	A 31% B 49%

...Expand

: 54-42-2
5-Iodo-2'-deoxyuridine

A: 951-78-0
2'-deoxyuridine

B: 73-39-2
C5-(allyl)-2'-deoxyuridine

Conditions

Conditions	Yield
With allyl-trimethyl-silane In water; acetonitrile Irradiation;	A 31% B 49%
With allyl-trimethyl-silane In water; acetonitrile for 10h; Ambient temperature; Irradiation;	A 31% B 49%

: 1140622-58-7
2'-deoxy-3',5'-bis-O-triphenylmethyluridine

: 100-51-6
benzyl alcohol

A: 519-73-3
triphenylmethane

B: 5333-62-0
benzyl trityl ether

C: 951-78-0
2'-deoxyuridine

D: 66-22-8
uracil

Conditions

Conditions	Yield
With copper(II) sulfate In xylene for 5h; Heating;	A n/a B n/a C 49% D n/a

...Expand

: 76223-04-6
1-((2R,4S,5R)-5-((tert-butyldimethylsilyloxy)methyl)-4-hydroxy-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

: 100-51-6
benzyl alcohol

A: 53172-91-1
(benzyloxy)(tert-butyl)dimethylsilane

B: 951-78-0
2'-deoxyuridine

C: 65-71-4
thymin

Conditions

Conditions	Yield
With copper(II) sulfate In xylene Heating;	A n/a B 49% C n/a

...Expand

: 14270-73-6
O5'-trityl-2'-deoxy-uridine

: 100-51-6
benzyl alcohol

A: 519-73-3
triphenylmethane

B: 5333-62-0
benzyl trityl ether

C: 951-78-0
2'-deoxyuridine

D: 66-22-8
uracil

Conditions

Conditions	Yield
With copper(II) sulfate In xylene for 5h; Heating;	A n/a B n/a C 49% D n/a

...Expand

: 15441-06-2
dimethyl 3,3'-dithiodipropionate

: 65505-76-2
C5-chloromercuri-2'-deoxyuridine

A: 951-78-0
2'-deoxyuridine

B: 118042-44-7
5-<3-(Methoxycarbonyl)-1-thiapropyl>-2'-deoxyuridine

Conditions

Conditions	Yield
With lithium tetrachloropalladate(II) In methanol for 16h; Ambient temperature;	A n/a B 46%

...Expand

: 110-91-8
morpholine

: 1165952-92-0
cyclohexa-1,4-diene

: 54-42-2
5-Iodo-2'-deoxyuridine

A: 1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-(5-morpholin-4-yl-cyclohex-3-enyl)-1H-pyrimidine-2,4-dione

B: 951-78-0
2'-deoxyuridine

Conditions

Conditions	Yield
With tetrabutyl-ammonium chloride; zinc(II) chloride; bis(dibenzylideneacetone)-palladium(0) In acetonitrile at 100℃; for 24h;	A n/a B 40%

...Expand

: 14270-73-6
O5'-trityl-2'-deoxy-uridine

A: 1140622-61-2
2'-deoxy-3'-O-triphenylmethyluridine

B: 1140622-58-7
2'-deoxy-3',5'-bis-O-triphenylmethyluridine

C: 951-78-0
2'-deoxyuridine

D: 66-22-8
uracil

Conditions

Conditions	Yield
With copper(II) sulfate In xylene for 4h; Heating;	A 6% B 37% C 10% D n/a

...Expand

: 76223-04-6
1-((2R,4S,5R)-5-((tert-butyldimethylsilyloxy)methyl)-4-hydroxy-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

A: 951-78-0
2'-deoxyuridine

B: 64911-18-8
3',5'-O-di(tert-butyldimethylsilyl)-2'-deoxyuridine

C: 76223-05-7
1-((2R,4S,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

D: 66-22-8
uracil

Conditions

Conditions	Yield
With copper(II) sulfate In xylene Heating;	A 10% B 36% C 6% D n/a

...Expand

: 60136-06-3
5-tert-Butyl-2'-deoxyuridine

A: 951-78-0
2'-deoxyuridine

B: 4-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-7,7-dimethyl-2,4-diaza-bicyclo[4.2.0]octa-1,5-dien-3-one

Conditions

Conditions	Yield
In water for 48h; Irradiation;	A n/a B 35%

: 56-87-1
L-lysine

: 1-(β-D-2'-deoxyribofuranosyl)-2-oxopyrimidine-4-diazoate

A: 951-78-0
2'-deoxyuridine

B: dCyd-εLys

C: dCyd-αLys

Conditions

Conditions	Yield
In various solvent(s) at 37℃; for 72h; pH=7.4; Kinetics;	A 11.1% B 13.4% C 28%

...Expand

: 109368-38-9
O5'-acetyl-2'-iodo-2'-deoxy-uridine

: 951-78-0
2'-deoxyuridine

Conditions

Conditions	Yield
With Pd-BaSO4; ammonia Hydrogenation;

: 34279-87-3
1-(O3,O5-bis-trimethylsilanyl-β-D-erythro-2-deoxy-pentofuranosyl)-5-bromo-4-trimethylsilanyloxy-1H-pyrimidin-2-one

: 75-24-1
trimethylaluminum

A: 951-78-0
2'-deoxyuridine

B: 50-89-5
thymidine

Conditions

Conditions	Yield
With water; ammonium chloride; triphenylphosphine 1) THF, reflux, 12 h, 2) MeOH, reflux, 3 h; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 75-77-4
chloro-trimethyl-silane

: 116-15-4
perfluoropropylene

: 54-42-2
5-Iodo-2'-deoxyuridine

A: 951-78-0
2'-deoxyuridine

B: 83107-63-5, 83107-64-6
(E)-2'-deoxy-5-(perfluoropropen-1-yl)uridine

C: 83107-64-6
(Z)-2'-deoxy-5-(perfluoropropen-1-yl)uridine

D: 70523-31-8
5-Trimethylsilyl-2'-deoxy-β-uridine

Conditions

Conditions	Yield
With pyridine; n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane Yield given. Multistep reaction. Title compound not separated from byproducts;

...Expand

: 75-77-4
chloro-trimethyl-silane

: 79-38-9
Chlorotrifluoroethylene

: 54-42-2
5-Iodo-2'-deoxyuridine

A: 951-78-0
2'-deoxyuridine

B: 82473-10-7
(E)-5-(2-chloro-1,2-difluorovinyl)-2'-deoxyuridine

C: 82473-11-8
(Z)-5-(2-chloro-1,2-difluorovinyl)-2'-deoxyuridine

D: 70523-31-8
5-Trimethylsilyl-2'-deoxy-β-uridine

Conditions

Conditions	Yield
With pyridine; n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane Yield given. Multistep reaction. Yields of byproduct given;
With pyridine; n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 951-78-0
2'-deoxyuridine

: 5626-99-3
Tetrahydrodeoxyuridine

Conditions

Conditions	Yield
With hydrogen; Rh/Al2O3 In methanol under 1810.02 Torr; for 4h;	100%
With 5% Rh/Al2O3; hydrogen In water under 2327.23 Torr; for 18h;	100%
With Rh/Al2O3; hydrogen In water at 20℃; under 22502.3 Torr;	96%

: 951-78-0
2'-deoxyuridine

: 54-42-2
5-Iodo-2'-deoxyuridine

Conditions

Conditions	Yield
With iodine; silver nitrate In methanol at 40℃; for 3h;	100%
With iodine; silver nitrate In methanol at 40℃; for 3h;	100%
With sodium azide; Iodine monochloride In acetonitrile at 25℃; for 24h; Product distribution; Mechanism; other uracil nucleosides; other halogenation agents; var. temp. and time;	96%

: 69304-37-6
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

: 951-78-0
2'-deoxyuridine

: 98495-56-8
3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyuridine

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 23h;	100%
With pyridine for 2h;	94%
With pyridine for 2.5h; Ambient temperature;	91.5%

: 951-78-0
2'-deoxyuridine

: 108-24-7
acetic anhydride

: 13030-62-1
3',5'-di-O-acetyl-2'-deoxyuridine

Conditions

Conditions	Yield
With dmap	100%
With pyridine at 20℃; for 24h;	100%
With pyridine at 0 - 20℃; for 5h; Acetylation;	99%

: 951-78-0
2'-deoxyuridine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 64911-18-8
3',5'-O-di(tert-butyldimethylsilyl)-2'-deoxyuridine

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 50℃; for 3h;	100%
With pyridine; 1H-imidazole at 0 - 20℃;	100%
With 1H-imidazole In N,N-dimethyl-formamide Etherification;	97%

: 951-78-0
2'-deoxyuridine

: 58479-61-1
tert-butylchlorodiphenylsilane

: 183269-46-7
1-[5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at -50 - 20℃; for 4h;	100%
With 1H-imidazole In N,N-dimethyl-formamide at 0℃; for 1h;	87%
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 17h;	76%
With dmap In pyridine
With pyridine at 20℃; Etherification;

: 951-78-0
2'-deoxyuridine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 23669-79-6
DMT-dU

Conditions

Conditions	Yield
With pyridine for 3h; Ambient temperature;	99%
In pyridine at 20℃; for 3h;	98%
With pyridine at 20℃; for 21h;	93%

: 951-78-0
2'-deoxyuridine

: 14470-28-1
mono-4-methoxytrityl chloride

: 14270-73-6
O5'-trityl-2'-deoxy-uridine

Conditions

Conditions	Yield
With pyridine for 2h; Heating / reflux;	99%

: 951-78-0
2'-deoxyuridine

: 14470-28-1
mono-4-methoxytrityl chloride

: 70255-96-8
1-{4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydrofuran-2-yl}-1H-pyrimidine-2,4-dione

Conditions

Conditions	Yield
With pyridine for 2h; Heating;	99%
With pyridine; dmap at 50℃; for 40h; Inert atmosphere;	69%

: 951-78-0
2'-deoxyuridine

: 59-14-3
5-bromo-2'-deoxyuridine

Conditions

Conditions	Yield
With 1-(2-methoxyethyl)-3-methylimidazolium trifluoroacetate; N-Bromosuccinimide at 25℃; for 0.0833333h;	98%
With N-Bromosuccinimide; sodium azide In 1,2-dimethoxyethane; water at 25℃; for 24h;	90%
With ammonium cerium (IV) nitrate; 1-ethylene glycol monomethyl ether-3-methylimidazolium methanesulfonate; lithium bromide at 80℃; for 0.333333h;	86%

: 951-78-0
2'-deoxyuridine

: 3282-30-2
pivaloyl chloride

: 57846-84-1
O5'-(2,2-dimethyl-propionyl)-2'-deoxy-uridine

Conditions

Conditions	Yield
With pyridine at -20℃; for 3h;	98%

: 951-78-0
2'-deoxyuridine

: 66-22-8
uracil

Conditions

Conditions	Yield
With 18-crown-6 ether In dimethyl sulfoxide at 50℃; for 36h;	97.3%
With Lactobacillus animalis ATCC 35046 2’-N-deoxyribosyltransferase immobilized in DEAE-Sepharose; water for 1h; Enzymatic reaction;	22%
With potassium phosphate; 5'-amino-5'-deoxyuridine phosphorylase In Tris HCl buffer at 30℃; for 3h; pH=9; Kinetics; Concentration; Time; Enzymatic reaction;

: 951-78-0
2'-deoxyuridine

: 85272-31-7
di-tert-butylsilyl bis(trifluoromethanesulfonate)

: 117841-54-0
1-[3,5-O-(di-tert-butylsilylene)-2-deoxy-β-D-ribofuranosyl]uracil

Conditions

Conditions	Yield
	97%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 1h;	91%

: 951-78-0
2'-deoxyuridine

: 76-83-5
trityl chloride

: 14270-73-6
O5'-trityl-2'-deoxy-uridine

Conditions

Conditions	Yield
With pyridine at 50℃;	97%
With pyridine; dmap Inert atmosphere; Heating;	93%
With pyridine at 100℃; for 18h;	12.58 g

: 951-78-0
2'-deoxyuridine

: C20H23F2N7O2

: C25H31F2N7O5

Conditions

Conditions	Yield
With potassium dihydrogenphosphate; purine nucleoside phosphorylase Escherichia coli; uridine phosphorylase Escherichia coli In aq. phosphate buffer at 50℃; for 3h; pH=7.0; Kinetics; Enzymatic reaction; diastereoselective reaction;	97%

: 951-78-0
2'-deoxyuridine

: 1904-98-9
2,6-diaminopurine

: 4546-70-7
2-amino-2'-deoxyadenosine

Conditions

Conditions	Yield
With purine nucleoside phosphorylase; uridine phosphorylase In aq. phosphate buffer; dimethyl sulfoxide at 60℃; for 5h; pH=7; Solvent; Temperature; Enzymatic reaction;	96%

: 951-78-0
2'-deoxyuridine

: 98-88-4
benzoyl chloride

: 31615-99-3, 40632-45-9, 41545-90-8, 41545-91-9, 55903-98-5
3',5'-Di-O-benzoyl-2'-deoxyuridine

Conditions

Conditions	Yield
In pyridine at 0℃; for 1h;	95%
With pyridine at 50 - 55℃; for 72h;	91%
With pyridine for 1h; Ambient temperature;

: 951-78-0
2'-deoxyuridine

: 50-66-8
6-methylthiopurine

: 23526-11-6
S-methylthiodeoxyinosine

Conditions

Conditions	Yield
at 37℃; for 7h; alginate gel-entrapped cells of auxotrophic thymine-dependent strain of E. coli, ammonium acetate buffer pH 5.8;	95%

: 951-78-0
2'-deoxyuridine

: 5720-05-8
4-methylphenylboronic acid

: N3-p-tolyl-2'-deoxyuridine

Conditions

Conditions	Yield
With copper diacetate In dimethyl sulfoxide at 60℃; for 16h;	95%

: 51-17-2
benzoimidazole

: 951-78-0
2'-deoxyuridine

: 1-(2-deoxy-β-D-ribofuranosyl)-1,3-benzimidazole

Conditions

Conditions	Yield
With recombinant Escherichia coli purine nucleoside phosphorylase Ser90Ala mutant In aq. phosphate buffer; dimethyl sulfoxide at 50℃; for 24h; pH=7; Reagent/catalyst; Enzymatic reaction;	95%

: 951-78-0
2'-deoxyuridine

: 2926-29-6
Langlois reagent

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
With tert.-butylhydroperoxide In water at -3 - 60℃; for 2h; Temperature; Inert atmosphere;	94.3%
With tert.-butylhydroperoxide In water at -5 - 65℃; for 3h; Inert atmosphere; Large scale;	94.8%
With tert-butyl alcohol In water at 0 - 20℃; for 3h;	59%
With mesoporous graphitic carbon nitride In dimethyl sulfoxide at 25℃; Irradiation;	47%
With acetone In water at 20℃; for 40h; UV-irradiation; Inert atmosphere;	44%

: 106-43-4
para-chlorotoluene

: 951-78-0
2'-deoxyuridine

: 4449-38-1
2'-deoxy-3',5'-di-O-(4-methylbenzoyl)uridine

Conditions

Conditions	Yield
In pyridine 1.) 0 degC to R.T., 2.) 50 degC, 2 h;	94%

: 994-30-9
triethylsilyl chloride

: 951-78-0
2'-deoxyuridine

: 340721-64-4
2'-deoxy-3',5'-bis-O-(triethylsilyl)uridine

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 23℃; for 16h;	94%

: 2-benzofuranyl boronic acid

: 951-78-0
2'-deoxyuridine

: 5-(2-benzofuranyl)-2'-deoxyuridine

Conditions

Yield

Stage #1: 2'-deoxyuridine With (1,3,5-triaza-7-phosphaadamantan-1-ium-1-yl)butane-1-sulfonate; palladium diacetate In water at 80℃; for 0.0833333h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique; Green chemistry;
Stage #2: 2-benzofuranyl boronic acid With triethylamine In water at 80℃; Reagent/catalyst; Temperature; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique; Green chemistry;

94%

: 951-78-0
2'-deoxyuridine

: C11H11F2N3O

: C16H19F2N3O4

Conditions

Conditions	Yield
With uridine phosphorylase; purine nucleosidephosphorylase E.coli In aq. phosphate buffer at 50℃; for 2.5h; pH=7; Enzymatic reaction;	93%

2'-Deoxyuridine Consensus Reports

Reported in EPA TSCA Inventory.

2'-Deoxyuridine Specification

The 2'-Deoxyuridine, with the CAS registry number 951-78-0 and EINECS registry number 213-455-7, has the IUPAC name of 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione. It is a kind of white crystalline powder which is also air sensitive. The molecular formula of the chemical is C₉H₁₂N₂O₅. What's more, while dealing with this chemical, you should not breathe dust and then try to avoid contacting with skin and eyes.

The physical properties of 2'-Deoxyuridine are as followings: (1)ACD/LogP: -1.70; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.7; (4)ACD/LogD (pH 7.4): -1.74; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 2.82; (8)ACD/KOC (pH 7.4): 2.58; (9)#H bond acceptors: 7; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 68.31 Å²; (13)Index of Refraction: 1.603; (14)Molar Refractivity: 51.14 cm³; (15)Molar Volume: 148.8 cm³; (16)Polarizability: 20.27×10^-24cm³; (17)Surface Tension: 71.1 dyne/cm; (18)Density: 1.533 g/cm³.

Uses of 2'-Deoxyuridine: It is always used as an uridine derivative as therapeutic agent for treating allergy, cancer, infection and autoimmune disease. And it is also used as intermediates.

You should be cautious while dealing with this chemical. It irritates to eyes, respiratory system and skin. Therefore, you had better take the following instructions: Do not breathe dust and avoid contacting with skin and eyes; Wear suitable gloves and eye/face protection, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C/1NC(=O)N(\C=C\1)C2O[C@@H]([C@@H](O)C2)CO
(2)InChI: InChI=1/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8?/m0/s1
(3)InChIKey: MXHRCPNRJAMMIM-FWHJPCMOBR

Product Name

2'-Deoxyuridine

Synthetic route

2'-Deoxyuridine Consensus Reports

2'-Deoxyuridine Specification

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