Product Name

  • Name

    2-(Trifluoromethyl)benzyl bromide

  • EINECS 206-901-7
  • CAS No. 395-44-8
  • Article Data6
  • CAS DataBase
  • Density 1.568 g/cm3
  • Solubility
  • Melting Point 34-35 °C
  • Formula C8H6BrF3
  • Boiling Point 201.9 °C at 760 mmHg
  • Molecular Weight 239.035
  • Flash Point 83.3 °C
  • Transport Information UN 1760
  • Appearance Colorless to light yellow liquid
  • Safety 45-36/37/39-25-26
  • Risk Codes 34
  • Molecular Structure Molecular Structure of 395-44-8 (2-(Trifluoromethyl)benzyl bromide)
  • Hazard Symbols CorrosiveC， IrritantXi
  • Synonyms o-Xylene, a'-bromo-a,a,a-trifluoro- (6CI,7CI,8CI);1-(Bromomethyl)-2-(trifluoromethyl)benzene;2-Trifluoromethylbenzyl bromide;o-(Trifluoromethyl)benzyl bromide;a'-Bromo-a,a,a-trifluoro-o-xylene;
  • PSA 0.00000
  • LogP 3.60030

Synthetic route

diethyl 2,6-dimethyl-4-(2-(trifluoromethyl)benzyl)-1,4-dihydropyridine-3,5-dicarboxylate

diethyl 2,6-dimethyl-4-(2-(trifluoromethyl)benzyl)-1,4-dihydropyridine-3,5-dicarboxylate

o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

Conditions
ConditionsYield
With dipotassium peroxodisulfate; tris(2,2′-bipyridyl)dichlororuthenium(II) hexahydrate; sodium bromide In water; acetonitrile at 20℃; for 24h; Sealed tube; Inert atmosphere; Irradiation; regioselective reaction;62%
(2-(trifluoromethyl)phenyl)methanol
346-06-5

(2-(trifluoromethyl)phenyl)methanol

o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

Conditions
ConditionsYield
(bromination);
With pyridine; phosphorus tribromide at -10 - -5℃;
With sulfuric acid; hydrogen bromide
With carbon tetrabromide; triphenylphosphine In dichloromethane for 2h; Substitution; reflux;
With phosphorus tribromide In dichloromethane; water; toluene
[2-(trifluoromethyl)phenyl]magnesium bromide
395-47-1

[2-(trifluoromethyl)phenyl]magnesium bromide

o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: (bromination)
View Scheme
2-trifluoromethylbenzoic acid
433-97-6

2-trifluoromethylbenzoic acid

o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: LiAlH4 / diethyl ether
2: PBr3, Py / -10 - -5 °C
View Scheme
2-trifluoromethylphenylmagnesium chloride
3796-19-8

2-trifluoromethylphenylmagnesium chloride

o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: aq. HBr, H2SO4
View Scheme
2-Trifluoromethylbenzaldehyde
447-61-0

2-Trifluoromethylbenzaldehyde

o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetra(n-butyl)ammonium hydrogensulfate / ethylene glycol / 4 h / 80 °C / Sealed tube; Inert atmosphere
2: sodium bromide; dipotassium peroxodisulfate; tris(2,2′-bipyridyl)dichlororuthenium(II) hexahydrate / acetonitrile; water / 24 h / 20 °C / Sealed tube; Inert atmosphere; Irradiation
View Scheme
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

triphenylphosphine
603-35-0

triphenylphosphine

2-trifluoromethylbenzyltriphenylphosphonium bromide

2-trifluoromethylbenzyltriphenylphosphonium bromide

Conditions
ConditionsYield
In toluene for 12h; Reflux;100%
In toluene Reflux;77%
In toluene at 80℃; for 16h;
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

6-Mercaptopurine
157930-09-1, 157930-10-4, 157930-11-5, 157930-13-7, 157930-14-8

6-Mercaptopurine

A

6-((2-(trifluoromethyl)benzyl)thio)-9H-purine

6-((2-(trifluoromethyl)benzyl)thio)-9H-purine

B

9-[2-(trifluoromethyl) benzyl]-6-[(2-(trifluoromethyl)benzyl)thio]-9H-purine

9-[2-(trifluoromethyl) benzyl]-6-[(2-(trifluoromethyl)benzyl)thio]-9H-purine

Conditions
ConditionsYield
Stage #1: 6-Mercaptopurine With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 1h;
Stage #2: o-trifluoromethylbenzyl bromide In N,N-dimethyl-formamide at 20℃; Further stages;		A 91%
B 99%
...Expand
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

Quinoline-2-thiol
2637-37-8

Quinoline-2-thiol

2-((2-(trifluoromethyl)benzyl)thio)quinoline

2-((2-(trifluoromethyl)benzyl)thio)quinoline

Conditions
ConditionsYield
Stage #1: Quinoline-2-thiol With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 20℃; for 0.5h;
Stage #2: o-trifluoromethylbenzyl bromide In toluene at 20℃; for 17h;		99%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

m-nitrobenzene boronic acid
13331-27-6

m-nitrobenzene boronic acid

1-(3-nitrobenzyl)-2-(trifluoromethyl)benzene
886211-35-4

1-(3-nitrobenzyl)-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,2-dimethoxyethane; water at 50℃; for 16h;98%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

5-bromosalicyclaldehyde
1761-61-1

5-bromosalicyclaldehyde

5-bromo-2-[2-(trifluoromethyl)benzyloxy]benzaldehyde
1198307-34-4

5-bromo-2-[2-(trifluoromethyl)benzyloxy]benzaldehyde

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;98%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

phenylboronic acid
98-80-6

phenylboronic acid

1-benzyl-2-(trifluoromethyl)benzene
7552-71-8

1-benzyl-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
With trans-(imidazole-κN)diiodo(3-isopropylbenzothiazolin-2-ylidene)palladium(II); potassium carbonate In water; N,N-dimethyl-formamide at 60℃; for 2h; Suzuki-Miyaura coupling;98%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

methyl 2-cyanoacetate
105-34-0

methyl 2-cyanoacetate

methyl 2-cyano-3-[2-(trifluoromethyl)phenyl]-2-{[2-(trifluoromethyl)phenyl]methyl}propionate

methyl 2-cyano-3-[2-(trifluoromethyl)phenyl]-2-{[2-(trifluoromethyl)phenyl]methyl}propionate

Conditions
ConditionsYield
Stage #1: methyl 2-cyanoacetate With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 0℃; for 0.0333333h;
Stage #2: o-trifluoromethylbenzyl bromide In dichloromethane at 0 - 20℃;		98%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃;
ethyl 6-(4-fluorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-4-pyridazinecarboxylate
1040543-17-6

ethyl 6-(4-fluorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-4-pyridazinecarboxylate

o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

ethyl 6-(4-fluorophenyl)-5-hydroxy-3-oxo-2-{[2-(trifluoromethyl)phenyl]methyl}-2,3-dihydro-4-pyridazinecarboxylate
1040544-19-1

ethyl 6-(4-fluorophenyl)-5-hydroxy-3-oxo-2-{[2-(trifluoromethyl)phenyl]methyl}-2,3-dihydro-4-pyridazinecarboxylate

Conditions
ConditionsYield
Stage #1: ethyl 6-(4-fluorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-4-pyridazinecarboxylate With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 0.75h;
Stage #2: o-trifluoromethylbenzyl bromide In N,N-dimethyl-formamide at 0 - 20℃; for 3h;
Stage #3: With hydrogenchloride In water; N,N-dimethyl-formamide at 20℃;		97%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

4-methoxy-2-nitroaniline
96-96-8

4-methoxy-2-nitroaniline

4-methoxy-2-nitro-N-(2-(trifluoromethyl)benzyl)aniline

4-methoxy-2-nitro-N-(2-(trifluoromethyl)benzyl)aniline

Conditions
ConditionsYield
Stage #1: 4-methoxy-2-nitroaniline With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 0.5h; Inert atmosphere;
Stage #2: o-trifluoromethylbenzyl bromide In N,N-dimethyl-formamide at 90℃; Inert atmosphere;		97%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine
103057-44-9

N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine

(±)-tert-butyl 3-((2-(trifluoromethyl)benzyl)oxy)pyrrolidine-1-carboxylate

(±)-tert-butyl 3-((2-(trifluoromethyl)benzyl)oxy)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h; Inert atmosphere;
Stage #2: o-trifluoromethylbenzyl bromide In N,N-dimethyl-formamide at 0 - 25℃; for 16h; Inert atmosphere;		97%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

N-(diphenylmethylene)glycine tert-butyl ester
81477-94-3

N-(diphenylmethylene)glycine tert-butyl ester

(S)-tert-butyl 3-(2-trifluoromethylphenyl)-2-(diphenylmethyleneamino)propanoate

(S)-tert-butyl 3-(2-trifluoromethylphenyl)-2-(diphenylmethyleneamino)propanoate

Conditions
ConditionsYield
With C58H42F12N(1+)*Br(1-); potassium hydroxide In water; toluene at -20℃; for 3h; Reagent/catalyst; enantioselective reaction;96%
With C30H32N3O(1+)*Br(1-); potassium hydroxide In water; toluene at -40℃; for 10h; Reagent/catalyst; enantioselective reaction;95%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

trimethylphosphane
594-09-2

trimethylphosphane

trimethyl(2-(trifluoromethyl)benzyl)phosphonium bromide

trimethyl(2-(trifluoromethyl)benzyl)phosphonium bromide

Conditions
ConditionsYield
In toluene; acetonitrile at 20℃; for 1h; Inert atmosphere;96%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

demethyltetrandrine
436-77-1, 10172-02-8, 33889-68-8, 38769-07-2, 53834-87-0, 119478-08-9

demethyltetrandrine

C45H45F3N2O6

C45H45F3N2O6

Conditions
ConditionsYield
With triethylhexadecylammonium chloride In water at 200℃; for 0.1h; Reagent/catalyst; Solvent; Temperature;95.81%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

1-(azidomethyl)-2-(trifluoromethyl)benzene
823189-03-3

1-(azidomethyl)-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
With sodium azide In water; tert-butyl alcohol95.8%
With sodium azide In water; acetone90%
With sodium azide In water; acetone at 22℃;87%
3,4-dihydro-2(1H)-quinolone
553-03-7

3,4-dihydro-2(1H)-quinolone

o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

1-[2-(trifluoromethyl)benzyl]-3,4-dihydroquinolin-2(1H)-one
1247021-75-5

1-[2-(trifluoromethyl)benzyl]-3,4-dihydroquinolin-2(1H)-one

Conditions
ConditionsYield
Stage #1: 3,4-dihydro-2(1H)-quinolone With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃;
Stage #2: o-trifluoromethylbenzyl bromide In N,N-dimethyl-formamide at 20℃;		95%
(3α,5α)-3-hydroxy-3-(piperazin-1-ylmethyl)androstan-17-one
1326702-42-4

(3α,5α)-3-hydroxy-3-(piperazin-1-ylmethyl)androstan-17-one

o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

(3α,5α)-3-hydroxy-3-((4-[2-(trifluoromethyl)benzyl]-piperazin-1-yl)methyl)androstan-17-one
1326702-55-9

(3α,5α)-3-hydroxy-3-((4-[2-(trifluoromethyl)benzyl]-piperazin-1-yl)methyl)androstan-17-one

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃;95%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl isoselenuronium bromide
50793-60-7

2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl isoselenuronium bromide

2-(trifluoromethyl)benzyl 2,3,4,6-tetra-O-acetyl-1-seleno-β-D-glucopyranoside
1383478-50-9

2-(trifluoromethyl)benzyl 2,3,4,6-tetra-O-acetyl-1-seleno-β-D-glucopyranoside

Conditions
ConditionsYield
With triethylamine at 20℃;95%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

C18H21NO
115-46-8

C18H21NO

(1-(2-(trifluoromethyl)benzyl)piperidin-4-yl)diphenylmethanol

(1-(2-(trifluoromethyl)benzyl)piperidin-4-yl)diphenylmethanol

Conditions
ConditionsYield
With triethylamine In acetonitrile at 70℃; for 4h;95%
Na[CpMo(CO)3]
12107-35-6

Na[CpMo(CO)3]

o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

[CpMo(CO)3Bz-o-CF3]

[CpMo(CO)3Bz-o-CF3]

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 24h;95%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

mercaptoacetic acid
68-11-1

mercaptoacetic acid

2-[2-(trifluoromethyl)benzylthio]acetic acid

2-[2-(trifluoromethyl)benzylthio]acetic acid

Conditions
ConditionsYield
With sodium hydroxide In methanol at 20℃; for 1h;94.5%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

4-methylphenylboronic acid
5720-05-8

4-methylphenylboronic acid

1-(4-methylbenzyl)-2-(trifluoromethyl)benzene
1130704-36-7

1-(4-methylbenzyl)-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
With trans-(benzimidazole-κN)diiodo(3-isopropylbenzothiazolin-2-ylidene)palladium(II); potassium carbonate In water; N,N-dimethyl-formamide at 60℃; for 17h; Suzuki-Miyaura coupling;94%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

N-t-butoxycarbonyl-tyramine
64318-28-1

N-t-butoxycarbonyl-tyramine

tert-butyl (4-((2-(trifluoromethyl)benzyl)oxy)phenethyl)carbamate

tert-butyl (4-((2-(trifluoromethyl)benzyl)oxy)phenethyl)carbamate

Conditions
ConditionsYield
With potassium carbonate In acetone for 4h; Williamson Ether Synthesis; Reflux;94%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

N-(diphenylmethylene)glycine tert-butyl ester
81477-94-3

N-(diphenylmethylene)glycine tert-butyl ester

(R)-tert-butyl 3-(2-trifluoromethylphenyl)-2-(diphenylmethyleneamino)propanoate

(R)-tert-butyl 3-(2-trifluoromethylphenyl)-2-(diphenylmethyleneamino)propanoate

Conditions
ConditionsYield
With C28H28F6N3(1+)*Br(1-); potassium hydroxide In diethyl ether; water at -40℃; for 5h; enantioselective reaction;93%
4-tert-Butylstyrene
1746-23-2

4-tert-Butylstyrene

o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

butan-1-ol
71-36-3

butan-1-ol

1-(3-butoxy-3-(4-tert-butylphenyl)propyl)-2-(trifluoromethyl)benzene

1-(3-butoxy-3-(4-tert-butylphenyl)propyl)-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
With sodium carbonate; copper(l) chloride at 100℃; for 24h; Inert atmosphere; Schlenk technique;93%
...Expand
2-(4-chlorophenoxy)-1,3-propanedioic acid diethyl ester
24101-91-5

2-(4-chlorophenoxy)-1,3-propanedioic acid diethyl ester

o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

diethyl 2-(4-chlorophenoxy)-2-[2-(trifluormethyl)benzyl]malonate
1093231-91-4

diethyl 2-(4-chlorophenoxy)-2-[2-(trifluormethyl)benzyl]malonate

Conditions
ConditionsYield
Stage #1: 2-(4-chlorophenoxy)-1,3-propanedioic acid diethyl ester With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 0.333333h;
Stage #2: o-trifluoromethylbenzyl bromide In N,N-dimethyl-formamide at 20 - 60℃;		92%
1,1-dimethylethyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-1-pyrrolidnecarboxylate
940865-64-5

1,1-dimethylethyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-1-pyrrolidnecarboxylate

o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

1,1-dimethylethyl (3S)-3-((3-chloro-4-cyanophenyl){[2-(trifluoromethyl)phenyl]methyl}amino)-1-pyrrolidinecarboxylate
940865-65-6

1,1-dimethylethyl (3S)-3-((3-chloro-4-cyanophenyl){[2-(trifluoromethyl)phenyl]methyl}amino)-1-pyrrolidinecarboxylate

Conditions
ConditionsYield
Stage #1: 1,1-dimethylethyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-1-pyrrolidnecarboxylate With sodium hydride In N,N-dimethyl-formamide for 1h; Cooling with ice;
Stage #2: o-trifluoromethylbenzyl bromide In N,N-dimethyl-formamide at 0 - 25℃; for 1h;		92%
Stage #1: 1,1-dimethylethyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-1-pyrrolidnecarboxylate With sodium hydride In hexane; N,N-dimethyl-formamide at 0℃; for 1h;
Stage #2: o-trifluoromethylbenzyl bromide In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h;
Stage #3: With water; ammonium chloride In N,N-dimethyl-formamide		92%
Stage #1: 1,1-dimethylethyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-1-pyrrolidnecarboxylate With sodium hydride In N,N-dimethyl-formamide; mineral oil
Stage #2: o-trifluoromethylbenzyl bromide In N,N-dimethyl-formamide; mineral oil
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

(S)-1-(2,6-diisopropylphenyl)-4-isopropyl-4,5-dihydro-1H-imidazole

(S)-1-(2,6-diisopropylphenyl)-4-isopropyl-4,5-dihydro-1H-imidazole

(S)-1-(2,6-diisopropylphenyl)-4-isopropyl-3-(2-(trifluoromethyl)benzyl)-4,5-dihydro-1Himidazol-3-ium bromide

(S)-1-(2,6-diisopropylphenyl)-4-isopropyl-3-(2-(trifluoromethyl)benzyl)-4,5-dihydro-1Himidazol-3-ium bromide

Conditions
ConditionsYield
In toluene at 100℃; for 1h;92%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

(3aS,9bR)-8-hydroxy-6,9-dimethyl-3-methylene-3a,4,5,9b-tetrahydronaphtho[1,2-b]furan-2(3H)-one

(3aS,9bR)-8-hydroxy-6,9-dimethyl-3-methylene-3a,4,5,9b-tetrahydronaphtho[1,2-b]furan-2(3H)-one

(3aS,9bR)-6,9-dimethyl-3-methylene-8-((2-(trifluoromethyl)-benzyl)oxy)-3a,4,5,9b-tetrahydronaphtho[1,2-b]furan-2(3H)-one

(3aS,9bR)-6,9-dimethyl-3-methylene-8-((2-(trifluoromethyl)-benzyl)oxy)-3a,4,5,9b-tetrahydronaphtho[1,2-b]furan-2(3H)-one

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃;92%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

ethyl 1-(2-fluoropyridin-4-yl)-4-hydroxy-1H-pyrazole-3-carboxylate

ethyl 1-(2-fluoropyridin-4-yl)-4-hydroxy-1H-pyrazole-3-carboxylate

C19H15F4N3O3

C19H15F4N3O3

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 0℃; for 1h;92%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

C14H14N2O3

C14H14N2O3

3-(4-(2-(trifluoromethyl)benzyl)piperazine-1-carbonyl)-2H-chromen-2-one

3-(4-(2-(trifluoromethyl)benzyl)piperazine-1-carbonyl)-2H-chromen-2-one

Conditions
ConditionsYield
With triethylamine In acetonitrile for 8h; Reflux;91%

2-(Trifluoromethyl)benzyl bromide Chemical Properties

IUPAC Name: 1-(bromomethyl)-2-(trifluoromethyl)benzene
The MF of 2-(Trifluoromethyl)benzyl bromide(395-44-8): C8H6BrF3
The MW of 2-(Trifluoromethyl)benzyl bromide(395-44-8): 239.03
EINECS: 206-901-7
mp: 34-35 °C 
bp: 72 °C (7.5 mmHg) 
density: 1.57 
refractive index: 1.496-1.499 
Fp: 83 °C 
Sensitive: Lachrymatory
Solubility in water: Insoluble
Appearance: Colorless to light yellow liquid
Categories: Fluoro-contained benzyl bromide series
Synonyms: ALPHA'-BROMO-ALPHA,ALPHA,ALPHA-TRIFLUORO-O-XYLENE;2-(TRIFLUOROMETHYL)BENZYL BROMIDE;O-(TRIFLUOROMETHYL)BENZYL BROMIDE;Benzene,1-(bromomethyl)-2-(trifluoromethyl)-;TIMTEC-BB SBB006692;
The Structure of 2-(Trifluoromethyl)benzyl bromide(395-44-8):

2-(Trifluoromethyl)benzyl bromide Safety Profile

Hazard Codes: C,Xi
Risk Statements: 34
34:  Causes burns 
Safety Statements: 45-36/37/39-25-26
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) 
36/37/39:  Wear suitable protective clothing, gloves and eye/face protection 
25:  Avoid contact with eyes 
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
RIDADR: 1760
Hazard Note: Corrosive/Lachrymatory
HazardClass: 8
PackingGroup: III

2-(Trifluoromethyl)benzyl bromide Specification

1. First Aid Measures
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Skin:
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Eyes:
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
2. Handling and Storage
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling:
Wash thoroughly after handling. Use only in a well ventilated area. Ground and bond containers when transferring material. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.

Related Products

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View