2,3-Dichloropyridine supplier

Name
2,3-Dichloropyridine
EINECS 219-281-8
CAS No. 2402-77-9
Article Data55
CAS DataBase
Density 1.388 g/cm³
Solubility slightly soluble in water
Melting Point 64-67 °C(lit.)
Formula C₅H₃Cl₂N
Boiling Point 192.5 °C at 760 mmHg
Molecular Weight 147.992
Flash Point 87.5 °C
Transport Information
Appearance White to slightly beige crystalline powder
Safety 26-36-37/39
Risk Codes 36/37/38-22
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms Pyridine, 2,3-dichloro-;2,3-Dichloro-pyridine;
PSA 12.89000
LogP 2.38840

Synthetic route

: 14121-36-9
2,3,4,6-Tetrachloropyridine

: 2402-77-9
2,3-dichloro-pyridine

Conditions

Conditions	Yield
With hydrogen; triethylamine; urea; citric acid In ethyl acetate at 50℃; under 7500.75 Torr; for 7h; Solvent; Temperature; Pressure; Reagent/catalyst; Autoclave;	98.1%

: 6515-09-9
2,3,6-trichloropyridine

: 2402-77-9
2,3-dichloro-pyridine

Conditions

Conditions	Yield
With carbonylhydridetris(triphenylphosphine)rhodium(I); hydrogen; triethylamine In methanol at 60℃; under 450045 Torr; Temperature; Solvent; Pressure; Autoclave;	98%
With methanol; palladium 10% on activated carbon; 3-p-menthene at 60℃; for 4h; Temperature; Reagent/catalyst;	95%
With hydrogen In methanol at 75℃; under 750.075 Torr; for 8h; Reagent/catalyst; Autoclave;	95.3%

: 2402-78-0
2,6-dichloropyridine

A: 2402-77-9
2,3-dichloro-pyridine

B: 1513-65-1
2,6-difluoro pyridine

Conditions

Conditions	Yield
In dimethyl sulfoxide	A 96.3% B n/a

: 6298-19-7
2-chloro-3-aminopyridine

: 2402-77-9
2,3-dichloro-pyridine

Conditions

Conditions	Yield
Stage #1: 2-chloro-3-aminopyridine With hydrogenchloride; sodium nitrite In water at 5 - 15℃; for 0.75h; Stage #2: With hydrogenchloride; aminosulfonic acid; copper(II) chloride dihydrate In water at 55 - 62℃; Product distribution / selectivity;	95%
With hydrogenchloride; thionyl chloride; nitric acid In water at 0 - 5℃;	91%
With hydrogenchloride; sodium nitrite In water at -5 - 40℃; for 1h; Sandmeyer Reaction; Cooling with ice; Inert atmosphere;	83%

: 13466-35-8
2-hydroxy-3-chloropyridine

: 2402-77-9
2,3-dichloro-pyridine

Conditions

Conditions	Yield
With phosphorus pentachloride In 1,2-dichloro-ethane at 60 - 65℃; for 10h; Reagent/catalyst; Temperature; Solvent;	94.9%
With phosphorus pentachloride In 1,2-dichloro-ethane at 60 - 65℃; for 10h; Reagent/catalyst; Temperature;	94.9%
With trichlorophosphate In 1,2-dichloro-ethane; N,N-dimethyl-formamide Reflux;	43g

: 452-58-4
2,3-Diaminopyridine

: 2402-77-9
2,3-dichloro-pyridine

Conditions

Conditions	Yield
With hydrogenchloride; copper dichloride; sodium nitrite In water at 20 - 45℃; for 5h; Reagent/catalyst; Large scale;	89.5%

: 6636-78-8
2-chloro-3-hydroxypyridine

: 2402-77-9
2,3-dichloro-pyridine

Conditions

Conditions	Yield
With trichlorophosphate In N,N-dimethyl-formamide at 0 - 30℃; for 9h; Reagent/catalyst;	88%
With chlorine In dichloromethane at 35 - 40℃; for 4h; Solvent; Temperature;	126 g
With sulfolane; phosphorus pentachloride; trichlorophosphate at 150℃; for 6h; Reagent/catalyst;

: 628-13-7
pyridine hydrochloride

: 2402-77-9
2,3-dichloro-pyridine

Conditions

Conditions	Yield
With pyridine; hydrogen In water at 40 - 60℃; under 2250.23 - 3750.38 Torr; Reagent/catalyst; Temperature; Pressure; Large scale;	86.6%
With pyridine; hydrogen In water at 40 - 60℃; under 2250.23 - 3750.38 Torr; Temperature; Pressure; Reagent/catalyst; Large scale;	86.6%

: 5470-18-8
2-Chloro-3-nitropyridine

: 2402-77-9
2,3-dichloro-pyridine

Conditions

Conditions	Yield
With Dichlorophenylphosphine In various solvent(s) at 170℃; for 5h;	81%
With sulfolane; phosphorus pentachloride; trichlorophosphate at 150℃; for 6h; Reagent/catalyst;

: 3-chloro-2-pyridinesulfonic acid

: 2402-77-9
2,3-dichloro-pyridine

Conditions

Conditions	Yield
Stage #1: 3-chloro-2-pyridinesulfonic acid With hydrogenchloride; water In water at 103℃; for 5h; Stage #2: With sodium chlorate for 5h; Temperature; Reflux;	80.3%

: 626-60-8
3-Chloropyridine

: 78948-09-1
acetyl hypofluorite

: 2402-77-9
2,3-dichloro-pyridine

Conditions

Conditions	Yield
With dichloromethane	80%

: 57266-69-0
3-chloropyridine-2-carboxylic acid

: 2402-77-9
2,3-dichloro-pyridine

Conditions

Conditions	Yield
With tert-butylhypochlorite; dichloromethane; sodium hydrogencarbonate at 60℃; for 20h; Green chemistry;	80%
With tert-butylhypochlorite; sodium carbonate; sodium chloride In dichloromethane at 30℃; for 20h; Schlenk technique;	50%

: 177743-06-5
2-Ethoxy-3-chloropyridine

: 2402-77-9
2,3-dichloro-pyridine

Conditions

Conditions	Yield
With N,N-dimethyl-formamide; trichlorophosphate at 95℃; for 12h;	66%

: 2-Benzyloxy-3-chloro-pyridine

: 2402-77-9
2,3-dichloro-pyridine

Conditions

Conditions	Yield
With N,N-dimethyl-formamide; trichlorophosphate at 95℃; for 12h;	66%

Pyridin-Palladium(II)-chlorid-Komplex: Pyridin-Palladium(II)-chlorid-Komplex

A: 109-09-1
2-chloropyridine

B: 2402-77-9
2,3-dichloro-pyridine

C: 16063-70-0
2,3,5-trichloropyridine

Conditions

Conditions	Yield
With chlorine In cyclohexane at 75℃; for 1h;	A 9% B 62% C 4.5%

...Expand

: 626-60-8
3-Chloropyridine

: 2402-77-9
2,3-dichloro-pyridine

Conditions

Conditions	Yield
Stage #1: 3-Chloropyridine With n-butyllithium In hexane at -60℃; for 1h; Stage #2: With hexachloroethane In tetrahydrofuran; hexane at -60 - 20℃;	60%
Multi-step reaction with 3 steps 1: 3-chloro-benzenecarboperoxoic acid / chloroform / 20 °C 2: 30 h / Reflux 3: trichlorophosphate / 6 h / 100 °C View Scheme

: 13472-84-9
2-methoxy,3-chloropyridine

: 2402-77-9
2,3-dichloro-pyridine

Conditions

Conditions	Yield
With trichlorophosphate In N,N-dimethyl-formamide at 95℃; for 12h;	59%
With N,N-dimethyl-formamide; trichlorophosphate at 95℃; for 12h;	59%

: 41667-95-2
5,6-dichloronicotinic acid

: 2402-77-9
2,3-dichloro-pyridine

Conditions

Conditions	Yield
at 150℃; bei vorsichtiger Destillation unter vermindertem Druck;

: 1851-22-5
3-chloropyridine-N-oxide

A: 16110-09-1
2,5 dichloropyridine

B: 2402-77-9
2,3-dichloro-pyridine

C: 55934-00-4
3,4-dichloropyridine

Conditions

Conditions	Yield
With trichlorophosphate at 110℃; for 2h; Yield given. Yields of byproduct given;

...Expand

: 121983-37-7
2-Chloro-pyridine-3-diazonium; chloride

: 2402-77-9
2,3-dichloro-pyridine

Conditions

Conditions	Yield
With hydrogenchloride; copper(II) oxide In n-BuCl; water at 55 - 62℃; Product distribution / selectivity;
With hydrogenchloride; copper dichloride In n-Butyl chloride; water at 60℃; for 1.5h; Product distribution / selectivity;

: 6298-19-7
2-chloro-3-aminopyridine

A: 2402-77-9
2,3-dichloro-pyridine

B: 69212-33-5
3,3'-dithiobis(2-chloropyridine)

C: 6684-06-6
2-chloro-3-pyridinesulfonyl chloride

D: 6602-56-8
2-chloropyridine-3-sulfonic acid

E: 3,3'-sulfonylbis(2-chloropyridine)

Conditions

Conditions	Yield
Stage #1: 2-chloro-3-aminopyridine With hydrogenchloride; acetic acid; sodium nitrite In water at 0℃; Sandmeyer reaction; Stage #2: With sulfur dioxide; water; acetic acid; copper(l) chloride at 0℃; Sandmeyer reaction;

...Expand

: 462-08-8
pyridin-3-ylamine

: 2402-77-9
2,3-dichloro-pyridine

Conditions

Conditions	Yield
Stage #1: pyridin-3-ylamine With hydrogenchloride; iron(III) chloride; chlorine; sodium nitrite In water at -8 - 20℃; Stage #2: With hydrogenchloride; copper(l) chloride In water at 60 - 70℃;
Multi-step reaction with 2 steps 1: iron(III) chloride; hydrogenchloride; chlorine / water / 25 °C 2: iron(III) chloride; sodium nitrite / water / 30 °C View Scheme
Stage #1: pyridin-3-ylamine With hydrogenchloride; dihydrogen peroxide In water at 5℃; for 2h; Stage #2: With sodium nitrite In water at -5℃; for 0.416667h; Stage #3: With copper(l) chloride In dichloromethane; water at 15 - 30℃; for 1.33333h;
Multi-step reaction with 2 steps 1: dihydrogen peroxide / 1 h / 5 - 15 °C 2: copper(l) chloride; sodium nitrite / water / 0.5 h / 33 - 38 °C View Scheme

: 49609-84-9
2-Chloronicotinoyl chloride

: 2402-77-9
2,3-dichloro-pyridine

Conditions

Conditions	Yield
With oxalyl dichloride; palladium 10% on activated carbon In chlorobenzene at 380 - 395℃; for 1h; Time; Reagent/catalyst; Temperature; Solvent; Concentration; Inert atmosphere;	43 %Spectr.

: 98-92-0
nicotinamide

: 2402-77-9
2,3-dichloro-pyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium hydroxide; sodium hypochlorite / 2 h / 10 - 95 °C 2: iron(III) chloride; hydrogenchloride; chlorine / water / 25 °C 3: iron(III) chloride; sodium nitrite / water / 30 °C View Scheme
Multi-step reaction with 3 steps 1: sodium hypochlorite / water / 2.5 h / 0 - 100 °C 2: dihydrogen peroxide / 1 h / 5 - 15 °C 3: copper(l) chloride; sodium nitrite / water / 0.5 h / 33 - 38 °C View Scheme

: 98273-80-4
2-acetyloxy-3-chloropyridine

: 2402-77-9
2,3-dichloro-pyridine

Conditions

Conditions	Yield
With trichlorophosphate at 100℃; for 6h; Reagent/catalyst;

: 6515-09-9
2,3,6-trichloropyridine

A: 626-60-8
3-Chloropyridine

B: 2402-77-9
2,3-dichloro-pyridine

Conditions

Conditions	Yield
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; hydrogen; triethylamine In isopropyl alcohol at 85℃; under 3750.38 Torr; for 3h;

: 6515-09-9
2,3,6-trichloropyridine

A: 109-09-1
2-chloropyridine

B: 2402-77-9
2,3-dichloro-pyridine

Conditions

Conditions	Yield
With Wilkinson's catalyst; hydrogen; triethylamine In isopropyl alcohol at 85℃; under 3750.38 Torr; for 1h;

: 110-86-1
pyridine

A: 2402-77-9
2,3-dichloro-pyridine

B: 16063-70-0
2,3,5-trichloropyridine

Conditions

Conditions	Yield
Stage #1: pyridine With iron(III) chloride; chlorine In tetrachloromethane Large scale; Stage #2: With palladium on activated charcoal In tetrachloromethane; ethanol at 80℃; under 750.075 Torr; Reagent/catalyst; Solvent; Pressure; Temperature; Large scale;	A 8 kg B 1840.8 kg

: 17747-43-2
3-pyridyl acetate

: 2402-77-9
2,3-dichloro-pyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: chlorine / dichloromethane; water / 4 h / 20 - 30 °C 2: water / dichloromethane / 2 h / 35 - 40 °C 3: chlorine / dichloromethane / 4 h / 35 - 40 °C View Scheme

: 2402-77-9
2,3-dichloro-pyridine

: 14264-16-5, 53996-95-5, 62075-39-2, 39716-73-9
bis(triphenylphosphine)nickel(II) chloride

: 680973-41-5
[NiCl(ClC5H3N)(P(C6H5)3)]2

Conditions

Conditions	Yield
With Zn; azabis(isobutyronitrile) In tetrahydrofuran (Ar); stirring (25°C, 1 h); solvent removal, extracting (CH2Cl2), filtn., solvent removal, stirring (Et2O), filtn., recrystallization (CH2Cl2); elem. anal.;	99%

: 2402-77-9
2,3-dichloro-pyridine

: 109-97-7
pyrrole

: 914457-19-5
3-chloro-2-(1H-pyrrol-1-yl)pyridine

Conditions

Conditions	Yield
Stage #1: pyrrole With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h; Stage #2: 2,3-dichloro-pyridine In N,N-dimethyl-formamide at 80℃; for 3h;	99%

: 2402-77-9
2,3-dichloro-pyridine

: 22841-92-5
(3-chloro-2-pyridyl)hydrazine

Conditions

Conditions	Yield
With N-Methyldiethanolamine; hydrazine hydrate at 102 - 105℃; under 2250.23 - 3000.3 Torr; for 8h; Inert atmosphere; Autoclave; Large scale;	98.12%
With hydrazine hydrate In ethanol for 25h; Reflux;	97.6%
With hydrazine hydrate In ethanol for 25h; Reflux;	96%

: 273-53-0
benzoxazole

: 2402-77-9
2,3-dichloro-pyridine

: 2-(2-chloropyridin-3-yl)benzo[d]oxazole

Conditions

Conditions	Yield
With copper(l) iodide; potassium phosphate tribasic heptahydrate; palladium diacetate; nixantphos In N,N-dimethyl-formamide at 120℃; for 12h; Inert atmosphere;	98%

: 2402-77-9
2,3-dichloro-pyridine

: 5142-75-6
tri(p-tolyl)bismuth

: 892482-36-9
3-chloro-2-(4-methylphenyl)pyridine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In N,N-dimethyl acetamide at 90℃; for 4h; Inert atmosphere; Schlenk technique; regioselective reaction;	97%

: 2402-77-9
2,3-dichloro-pyridine

: 53976-65-1
2,3-dichloropyridine 1-oxide

Conditions

Conditions	Yield
With trifluoromethylsulfonic anhydride; urea hydrogen peroxide adduct In dichloromethane at 10 - 20℃;	96%
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 30℃; for 32h; Inert atmosphere;	74%
With dihydrogen peroxide; acetic anhydride 1.)r.t., 5 h 2.)60-65 deg C, 30 h;
With urea hydrogen peroxide adduct; trifluoroacetic anhydride In dichloromethane at 0 - 20℃;	11 g

: 2402-77-9
2,3-dichloro-pyridine

: 124-38-9
carbon dioxide

: 184416-84-0
2,3-dichloroisonicotinic acid

Conditions

Conditions	Yield
Stage #1: 2,3-dichloro-pyridine With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -75℃; for 2h; Stage #2: carbon dioxide at -78℃;	96%
Stage #1: 2,3-dichloro-pyridine With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78 - -25℃; for 3h; Stage #2: carbon dioxide In tetrahydrofuran; hexane at 20℃; for 18h; Stage #3: With hydrogenchloride; water In tetrahydrofuran; diethyl ether; hexane at 0 - 20℃;	80%

: 2402-77-9
2,3-dichloro-pyridine

: 76-37-9
2,2,3,3-tetrafluoropropanol

: 1355067-32-1
3-chloro-2-(2,2,3,3-tetrafluoropropyl)pyridine

Conditions

Conditions	Yield
Stage #1: 2,2,3,3-tetrafluoropropanol With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 1h; Stage #2: 2,3-dichloro-pyridine In tetrahydrofuran; mineral oil for 16h; Reflux;	96%
Stage #1: 2,2,3,3-tetrafluoropropanol With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 1h; Stage #2: 2,3-dichloro-pyridine In tetrahydrofuran; mineral oil for 16h; Reflux;	96%

: 2402-77-9
2,3-dichloro-pyridine

: 444993-18-4
2-(prop-2-yloxycarbonyl)-5-trfluoromethylphenylboronic acid

: 1310-65-2
lithium hydroxide

: 1423022-47-2
2-(3-chloro-pyridin-2-yl)-4-trifluoromethyl-benzoic acid

Conditions

Conditions	Yield
Stage #1: 2,3-dichloro-pyridine; 2-(prop-2-yloxycarbonyl)-5-trfluoromethylphenylboronic acid With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,4-dioxane; water at 30 - 110℃; for 20h; Inert atmosphere; Stage #2: lithium hydroxide In 1,4-dioxane; water at 70℃;	96%

...Expand

: 2402-77-9
2,3-dichloro-pyridine

: 3-bromo-4,5-dihydro-1H-pyrazole-5-carboxylic acid ethyl ester

: 500011-91-6
5-bromo-2-(3-chloro-pyridin-2-yl)-3,4-dihydro-2H-pyrazole-3-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With sodium ethanolate In ethanol at 83℃; for 3h;	94.9%

: 110-85-0
piperazine

: 2402-77-9
2,3-dichloro-pyridine

: 87394-55-6
1-(3-chloro-2-pyridyl)piperazine

Conditions

Conditions	Yield
In butan-1-ol for 3h; Reflux;	94%
In butan-1-ol for 18h; Reflux;	92%
In ethanol 1.) ice bath, 2.) room temperature;	90.8%

: 2402-77-9
2,3-dichloro-pyridine

: 25225-13-2
2-(adamantan-1-yloxy)ethan-1-amine

: N-[2-(1-adamantyloxy)ethyl]-3-chloropyridin-2-amine

Conditions

Conditions	Yield
With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate In 1,4-dioxane Reagent/catalyst; Solvent; Temperature; Inert atmosphere; Reflux;	94%

: 504-29-0
2-aminopyridine

: 2402-77-9
2,3-dichloro-pyridine

: 138144-95-3
3-chloro-N-(pyridin-2-yl)pyridin-2-amine

Conditions

Conditions	Yield
With potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate In toluene for 18h; Heating;	93%
With palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 180℃; for 0.5h; Buchwald-Hartwig amination; Inert atmosphere; Microwave irradiation; regioselective reaction;	81%
With palladium diacetate; triphenylphosphine; sodium t-butanolate In toluene at 120℃; for 17h; Inert atmosphere;	61.7%

: 2402-77-9
2,3-dichloro-pyridine

: 104-94-9
4-methoxy-aniline

: 370571-31-6
3-chloro-N-(4-methoxyphenyl)pyridin-2-amine

Conditions

Conditions	Yield
With potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate In toluene for 18h; Heating;	93%
With palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene for 18h; Buchwald-Hartwig reaction; Reflux; regioselective reaction;	93%
Stage #1: 2,3-dichloro-pyridine With palladium diacetate; triphenylphosphine; sodium t-butanolate In toluene under 20 Torr; for 0.166667h; Buchwald-Hartwig Coupling; Inert atmosphere; Stage #2: 4-methoxy-aniline In toluene at 100℃; for 16h; Buchwald-Hartwig Coupling; Inert atmosphere;	91%
With palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 180℃; for 0.5h; Buchwald-Hartwig amination; Inert atmosphere; Microwave irradiation; regioselective reaction;	82%

: 2402-77-9
2,3-dichloro-pyridine

: 10272-07-8
3,5-Dimethoxyaniline

: 1146547-65-0
C13H13ClN2O2

Conditions

Conditions	Yield
Stage #1: 2,3-dichloro-pyridine With palladium diacetate; triphenylphosphine; sodium t-butanolate In toluene under 20 Torr; for 0.166667h; Buchwald-Hartwig Coupling; Inert atmosphere; Stage #2: 3.5-dimethoxyaniline In toluene at 100℃; for 16h; Buchwald-Hartwig Coupling; Inert atmosphere;	93%
Stage #1: 2,3-dichloro-pyridine; 3.5-dimethoxyaniline With palladium diacetate; triphenylphosphine; sodium t-butanolate In o-xylene at 120℃; for 3h; Inert atmosphere; Stage #2: With palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tricyclohexylphosphine tetrafluoroborate In N,N-dimethyl acetamide; o-xylene at 145℃; for 16h; Inert atmosphere;	66%
With palladium diacetate; triphenylphosphine; sodium t-butanolate Inert atmosphere; Heating;

: 2402-77-9
2,3-dichloro-pyridine

: 824-79-3
sodium 4-methylbenzenesulfinate

: 1258786-39-8
3-chloro-2-(toluene-4-sulfonyl)-pyridine

Conditions

Conditions	Yield
With hydrogenchloride; tetrabutyl-ammonium chloride In N,N-dimethyl acetamide; water at 100℃; for 24h;	93%

: 5382-16-1
4-HYDROXYPIPERIDINE

: 2402-77-9
2,3-dichloro-pyridine

: 1250282-78-0
1-(3-chloropyridin-2-yl)piperidin-4-ol

Conditions

Conditions	Yield
In dimethyl sulfoxide at 120℃;	93%
In N,N-dimethyl-formamide at 80 - 90℃; for 3h;	1.76 g

: 2402-77-9
2,3-dichloro-pyridine

: 3-bromo-4,5-dihydro-1H-pyrazole-5-carboxylic acid methyl ester

: 3-bromo-1-(3-chloro-2-pyridyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid methyl ester

Conditions

Conditions	Yield
With sodium methylate In methanol at 80℃; for 3h;	92.7%

: 2402-77-9
2,3-dichloro-pyridine

: 177-11-7
4,4-ethylenedioxy-piperidine

: 828265-97-0
C12H15ClN2O2

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 150℃; for 16h;	92.5%
With triethylamine In ethanol at 160℃;
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 125℃; for 12h;

: 2402-77-9
2,3-dichloro-pyridine

: 33397-21-6
tris(4-methoxyphenyl)bismuth

: 3-chloro-2-(4-methoxyphenyl)pyridine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In N,N-dimethyl acetamide at 90℃; for 4h; Inert atmosphere; Schlenk technique; regioselective reaction;	92%

: 5049-61-6
2-Aminopyrazine

: 2402-77-9
2,3-dichloro-pyridine

: (2-pyrazyl)(3-chloro-2-pyridyl)amine

Conditions

Conditions	Yield
With potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate In toluene for 18h; Heating;	91%

: 2402-77-9
2,3-dichloro-pyridine

: 90-04-0
2-methoxy-phenylamine

: 1005499-19-3
3-chloro-N-(2-methoxyphenyl)pyridin-2-amine

Conditions

Conditions	Yield
With palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene for 18h; Buchwald-Hartwig reaction; Reflux; regioselective reaction;	91%
Stage #1: 2,3-dichloro-pyridine With palladium diacetate; triphenylphosphine; sodium t-butanolate In toluene under 20 Torr; for 0.166667h; Buchwald-Hartwig Coupling; Inert atmosphere; Stage #2: 2-methoxy-phenylamine In toluene at 100℃; for 16h; Buchwald-Hartwig Coupling; Inert atmosphere;	82%
With potassium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 120℃; for 2h;	81%

: 2402-77-9
2,3-dichloro-pyridine

: 100-46-9
benzylamine

: 1042512-03-7
N-benzyl-3-chloro-2-pyridinamine

Conditions

Conditions	Yield
With palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 130℃; for 16h; Inert atmosphere;	91%
With palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 130℃; for 16h; Buchwald-Hartwig Coupling; Inert atmosphere;	91%
With palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 130℃; for 16h; Inert atmosphere;	91%
With palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 130℃; for 16h; Inert atmosphere;	90%
With palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 180℃; for 0.5h; Buchwald-Hartwig amination; Inert atmosphere; Microwave irradiation; regioselective reaction;	52%

: 2402-77-9
2,3-dichloro-pyridine

: 123324-71-0
4-tert-butylphenylboronic acid

: C15H16ClN

Conditions

Conditions	Yield
With palladium diacetate; potassium carbonate; nixantphos In tetrahydrofuran; water at 20℃; for 6h; Suzuki-Miyaura Coupling;	91%

: 2402-77-9
2,3-dichloro-pyridine

: 62673-31-8
benzyl(bromo)zinc

: 2-benzyl-3-chloropyridine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 70℃; for 18h; Inert atmosphere;	91%

2,3-Dichloropyridine Chemical Properties

Molecular Structure of 2,3-Dichloropyridine (CAS NO.2402-77-9):

IUPAC Name: 2,3-Dichloropyridine
Canonical SMILES: C1=CC(=C(N=C1)Cl)Cl
InChI: InChI=1S/C5H3Cl2N/c6-4-2-1-3-8-5(4)7/h1-3H
InChIKey: MAKFMOSBBNKPMS-UHFFFAOYSA-N
Molecular Weight: 147.99002 [g/mol]
Molecular Formula: C₅H₃Cl₂N
XLogP3: 2.1
H-Bond Donor: 0
H-Bond Acceptor: 1
EINECS: 219-281-8
Index of Refraction: 1.553
Molar Refractivity: 34.13 cm³
Molar Volume: 106.5 cm³
Surface Tension: 43.1 dyne/cm
Density: 1.388 g/cm³
Flash Point: 87.5 °C
Enthalpy of Vaporization: 41.11 kJ/mol
Boiling Point: 192.5 °C at 760 mmHg
Vapour Pressure: 0.679 mmHg at 25 °C
Appearance: White to slightly beige crystalline powder
Melting Point: 64-67 °C(lit.)
Water Solubility: slightly soluble
Product Categories: blocks; Pyridines; Pyridine; Halides; Heterocycles; Pyridines, Pyrimidines, Purines and Pteredines; Pyridine series; Pyridines derivates; Chloropyridines; Halopyridines; Boronic Acid; C5Heterocyclic Building Blocks; Halogenated Heterocycles; Heterocyclic Building Blocks; Chlorinated heterocyclic series

2,3-Dichloropyridine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	135mg/kg (135mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ANTIPSYCHOTIC LIVER: FATTY LIVER DEGERATION	Toxicology and Applied Pharmacology. Vol. 11, Pg. 361, 1967.

2,3-Dichloropyridine Safety Profile

Safety Information of 2,3-Dichloropyridine (CAS NO.2402-77-9):
Hazard Codes: Irritant Xi, Harmful Xn
Risk Statements: 36/37/38-22
R36/37/38:Irritating to eyes, respiratory system and skin.
R22:Harmful if swallowed.
Safety Statements: 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany: 3
RTECS: US8050000
Hazard Note: Irritant
HazardClass: IRRITANT

2,3-Dichloropyridine Specification

2,3-Dichloropyridine (CAS NO.2402-77-9), its Synonyms are Pyridine, 2,3-dichloro- ; 2,3-Dichlopyridine ; 2,3-Dichloro-pyridine .

Product Name

2,3-Dichloropyridine

Synthetic route

2,3-Dichloropyridine Chemical Properties

2,3-Dichloropyridine Toxicity Data With Reference

2,3-Dichloropyridine Safety Profile

2,3-Dichloropyridine Specification

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