2-Acetylpyridine supplier | CasNO.1122-62-9

Name
2-Acetylpyridine
EINECS 214-355-6
CAS No. 1122-62-9
Article Data172
CAS DataBase
Density 1.06 g/cm³
Solubility Soluble in water (18.2 g/100g @ 25C). Soluble in and acetate. Slightly soluble in carbon tetrachloride.
Melting Point 8-10 ºC
Formula C₇H₇NO
Boiling Point 192.8 ºC at 760 mmHg
Molecular Weight 121.139
Flash Point 73.3 ºC
Transport Information
Appearance clear colorless to slightly brown liquid
Safety 26-36-37
Risk Codes 36/37/38-38
Molecular Structure
Hazard Symbols Xi
Synonyms FEMA 3251;2-Acetopyridine;1-(2-Pyridinyl)ethanone;Ethanone, 1-(2-pyridinyl)-;1-pyridin-2-ylethanone;Methyl 2-pyridyl ketone;Ketone, methyl 2-pyridyl;2-Acetylpyridine (natural);2-Pyridyl methyl ketone;2-Acetyl pyridine;Acetyl Pyridine;
PSA 29.96000
LogP 1.28420

Synthetic route

: 2457-50-3
2-acetylpyridine N-oxide

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
With cis-Cyclooctene; trans-dioxo(5,10,15,20-tetramesitylporphirinato)ruthenium(VI) In benzene at 80℃; for 15h;	99%

: 2,3-Dihydro-3-oxo-1H-4λ5-pyrrolo[1,2-a]pyridin-4-ylium-1-olate

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
With sodium hydroxide; water at 20℃; Decarboxylation; Ring cleavage;	99%

: 7734-05-6
2-acetylpyridine phenylhydrazone

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
With Oxone; water; potassium hydrogencarbonate In acetone for 0.5h; Heating;	96%
With sulfuric acid; silica gel In hexane for 1.5h;

: 20988-55-0, 18728-61-5, 27911-63-3, 59042-90-9
1-(pyridine-2-yl)ethanol

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
With 9-azabicyclo[3.3.1]nonan-3-one N-oxyl oxide; oxygen; nitric acid; sodium nitrite In acetonitrile at 20℃; under 760.051 Torr; for 3h; Reagent/catalyst; Solvent;	94%
With Langlois reagent In acetonitrile at 25℃; for 12h; Irradiation; Sealed tube;	93%
With (NH4)4[CuMo6O18(OH)6]·5H2O; oxygen; sodium chloride In water; acetonitrile at 60℃; for 24h;	91%

: 98-98-6
2-Picolinic acid

: 917-54-4
methyllithium

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
Stage #1: methyllithium With copper(l) cyanide In diethyl ether at 0℃; for 0.0833333h; Inert atmosphere; Stage #2: 2-Picolinic acid In diethyl ether at 0 - 20℃; for 15h; Inert atmosphere;	94%

: 100-71-0
2-Ethylpyridine

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
With tert.-butylhydroperoxide In water; acetonitrile at 50℃; for 15h; Electrolysis;	93%
With pyridine; N-hydroxyphthalimide; tetrabutylammonium perchlorate In acetone; acetonitrile at 50℃; Electrochemical reaction;	89%
With pyridine; N-hydroxyphthalimide; oxygen; tetrabutylammonium dihydrogen phosphate In acetone; acetonitrile at 50℃; under 760.051 Torr; for 18h; Reagent/catalyst; Solvent; Heating;	82%

: 123440-85-7
t-butyl 3-oxo-3-(2-pyridyl)propanoate

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
With sulfuric acid at 60 - 70℃; for 8h; Reagent/catalyst;	92.6%

: 1945-84-2
2-ethynylpyridine

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
With C20H14AuN2O2(1+)*Cl(1-); water; trifluoroacetic acid In methanol at 80℃; for 5h; Sealed tube;	92%
With Ag3STA; water at 100℃; for 6h; neat (no solvent); regioselective reaction;	88%
With water; silver trifluoromethanesulfonate for 10h; Heating;	82%

: 17997-47-6
2-tri-n-butylstannylpyridine

: 5704-66-5
pyruvoyl chloride

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
In benzene for 0.5h; Ambient temperature;	91%

: 1758-54-9, 79462-42-3, 81563-77-1
1-pyridin-2-yl-ethanone oxime

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
With tetrachlorosilane; silica gel In hexane; water for 0.42h; Heating;	90%
With molybdenum(V) chloride; zinc In acetonitrile at 20℃; for 0.5h;	85%
With [bis(acetoxy)iodo]benzene In dichloromethane for 0.5h; Ambient temperature;	61%
With oxygen In acetonitrile at 27 - 37℃; under 760.051 Torr; for 7h; Irradiation;	100 %Chromat.
With oxygen In acetonitrile under 760.051 Torr; for 48h; Irradiation;	38 %Chromat.

: 10445-92-8
2-(1-chloroethyl)pyridine

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
With 4Na(1+)6H(1+)NiMo6O24(10-)=Na4H6NiMo6O24; oxygen In water; acetonitrile at 20℃; under 760.051 Torr; for 12h; Irradiation;	90%
With (NH4)4[ZnMo6O18(OH)6]; oxygen In water; acetonitrile at 60℃; under 760.051 Torr; for 12h;	83%

: 109-04-6
2-bromo-pyridine

: 97674-02-7
tributyl(1-ethoxyvinyl)stannane

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
Stage #1: 2-bromo-pyridine; tributyl(1-ethoxyvinyl)stannane With copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride In acetonitrile Stille reaction; Heating; Stage #2: With hydrogenchloride In acetonitrile for 1h; Heating;	88%

: 109-04-6
2-bromo-pyridine

: 111-34-2
-butyl vinyl ether

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
Stage #1: 2-bromo-pyridine; -butyl vinyl ether With 1,3-bis-(diphenylphosphino)propane; triethylamine; palladium diacetate In various solvent(s) at 125℃; for 30h; Regioselective Heck arylation; Stage #2: With hydrogenchloride In various solvent(s) for 1h;	88%

: 54856-82-5
3-methyl-[1,2,3]triazolo[1,5-a]pyridine

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
With selenium(IV) oxide In chlorobenzene at 132℃; for 10h;	84%

: 13737-05-8
2-trimethylstannylpyridine

: 5704-66-5
pyruvoyl chloride

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
In benzene for 0.5h; Ambient temperature;	83%

: 21970-13-8
(pyridin-2-yl)magnesium bromide

: 75-36-5
acetyl chloride

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
Stage #1: acetyl chloride With 1-methyl-pyrrolidin-2-one In toluene at 0℃; for 0.5h; Stage #2: (pyridin-2-yl)magnesium bromide In tetrahydrofuran; toluene at -10 - -5℃; for 4.25h; chemoselective reaction;	79%

: 5029-67-4
2-iodopyridine

: 201230-82-2
carbon monoxide

: 143-36-2
methylmercury(II) iodide

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
With dichloro bis(acetonitrile) palladium(II); tetra-(n-butyl)ammonium iodide In N,N,N,N,N,N-hexamethylphosphoric triamide under 760 Torr; for 7h; Ambient temperature;	78%

...Expand

: 100-69-6
2-vinylpyridine

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
With palladium diacetate; Dess-Martin periodane In water; acetonitrile at 50℃; Wacker-Tsuji Olefin Oxidation; Inert atmosphere;	76%
With dihydrogen peroxide In water; acetonitrile at 55℃; for 12h; Wacker Oxidation;	75%
Stage #1: 2-vinylpyridine With N-iodo-succinimide; oxygen In water; ethyl acetate for 7h; Wacker type oxidation; Visible light irradiation; Air atmosphere; Stage #2: With acetone; trifluoroacetic acid In water; ethyl acetate at 60℃; for 3h; Wacker type oxidation; Air atmosphere;	64%
With methanol; sodium hydroxide; chlorine Erwaermen der Reaktionsloesung nach Zusatz von Natriumhydroxid und anschliessenden Erwaermen mit wss.Salzsaeure;

: 2,5-bis(2-pyridyl)-3,4-diaza-2,4-hexadiene

A: 1122-62-9
2-acetylpyridine

B: 54856-82-5
3-methyl-[1,2,3]triazolo[1,5-a]pyridine

Conditions

Conditions	Yield
With ammonium cerium(IV) nitrate In water; acetonitrile at 20℃; for 20h;	A 75% B 23%
With 2-phenyl-1,2-benzoisoselenazol-3(2H)-one; dihydrogen peroxide In methanol for 45h; Heating;	A 58% B 42%

: 49669-13-8
1-(6-bromopyridin-2-yl)-ethanone

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
With sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; palladium diacetate; triphenylphosphine In tetrahydrofuran at 25℃; for 7h; Inert atmosphere; chemoselective reaction;	74%

: 950993-48-3
2-[1,1-bis(methylthio)]ethylpyridine

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
With calcium carbonate; mercury dichloride In water; acetonitrile at 20℃;	73%

: 87251-88-5
Fructose-methionine Amadori intermediate

A: 64265-26-5
2,4-Dimethyltetrahydrofuran

B: 96-54-8
N-Methylpyrrole

C: 109-08-0
2-Methylpyrazine

D: 1122-62-9
2-acetylpyridine

E: 3268-49-3
3-(methylsulfenyl)propanal

F: 3740-59-8
3,4-dihydro-6-methyl-2H-pyran-2-one

Conditions

Conditions	Yield
at 260℃; for 0.0833333h; Thermal degradation;	A n/a B n/a C n/a D n/a E 70% F n/a

...Expand

: 2524-52-9
ethyl-2-picolinate

: 141-78-6
ethyl acetate

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
	69%

: 219879-89-7
2-<1-butylsulfanyl-1-(methylsulfanyl)ethyl>pyridine

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
With sulfuric acid In water for 0.75h; Heating;	67%

: 2,5-bis(2-pyridyl)-3,4-diaza-2,4-hexadiene

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
With ammonium cerium(IV) nitrate In water; acetonitrile at 20℃; for 24h; Oxidation;	61%

: 26510-52-1
ethyl 2-pyridylcarbonylacetate

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
Stage #1: ethyl 2-pyridylcarbonylacetate With sulfuric acid In water for 2h; Heating / reflux; Stage #2: With sodium hydroxide In water	60%

: 2459-07-6
methyl pyridine-2-carboxylate

: 75-24-1
trimethylaluminum

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
In dichloromethane -78 deg C to -20 deg C, 30 min, -20 deg C, 12 h;	54%

: 6515-13-5
2-isopropenylpyridine

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
With 2,6-dimethylpyridine; sodium periodate; ruthenium(III) chloride trihydrate In dichloromethane; water; acetonitrile at 20℃; for 1h; Inert atmosphere;	47%

: 32081-57-5
α-methyl-2-pyridylacetonitrile

: 1122-62-9
2-acetylpyridine

Conditions

Conditions	Yield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In toluene for 48h;	45%

: 110-86-1
pyridine

: 1122-62-9
2-acetylpyridine

: 26482-00-8
1-(2-oxo-2-(2-pyridyl)ethyl)pyridinium iodide

Conditions

Conditions	Yield
With iodine	100%
With iodine for 3h; Heating;	100%
With iodine at 140℃; for 3h;	100%

: 1122-62-9
2-acetylpyridine

: 20988-55-0, 18728-61-5, 27911-63-3, 59042-90-9
1-(pyridine-2-yl)ethanol

Conditions

Conditions	Yield
With magnesium(II) perchlorate; polymer-bound NADH (2a) In acetonitrile; benzene at 80℃; for 120h; Further byproducts given;	100%
With polimer supported sodium borohydride In methanol at 20℃; for 72h; not specified;	100%
With [bis({2‐[bis(propan‐2‐yl)phosphanyl]ethyl})amide](carbonyl)(hydride)iron(II); hydrogen In tetrahydrofuran at 50℃; under 3750.38 Torr; for 4h; Glovebox; chemoselective reaction;	100%

: 1122-62-9
2-acetylpyridine

: 54-85-3
isoniazid

: 93086-96-5
N’-(1-(pyridin-2-yl)ethylidene)isonicotinohydrazide

Conditions

Conditions	Yield
In methanol at 20℃;	100%
In methanol at 20℃; for 1h;	100%
In ethanol for 0.0833333h; Concentration; Temperature; Time; Microwave irradiation; Green chemistry;	86%

: 1122-62-9
2-acetylpyridine

: 27911-63-3
(R)-1-(2'-pyridyl)ethanol

Conditions

Conditions	Yield
With formic acid; C38H40ClN2O2RhS; triethylamine In neat (no solvent) at 24 - 30℃; for 6.5h; Reagent/catalyst; Inert atmosphere; enantioselective reaction;	100%
With formic acid; C38H39ClN2O3RhS; triethylamine at 20℃; for 4.5h; enantioselective reaction;	99%
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; (SC,SC,RFC)-1-(diphenylphosphino)-2-[1-N-((4S)-4-tert-butyl-2-oxazolinyl-2-ylmethyl)ethyl]ferrocene; hydrogen; potassium carbonate In isopropyl alcohol at 25℃; under 15201 Torr; for 2h; Glovebox; Autoclave; enantioselective reaction;	99%

: 98-01-1
furfural

: 1122-62-9
2-acetylpyridine

: 1-(2-pyridyl)-3-(2-furyl)-prop-2-ene-1-one

Conditions

Conditions	Yield
With sodium hydroxide In methanol at 0℃; for 2h; Condensation;	100%

: 1122-62-9
2-acetylpyridine

: 100-63-0
phenylhydrazine

: 7734-05-6
2-acetylpyridine phenylhydrazone

Conditions

Conditions	Yield
In ethanol at 50℃; for 1.5h;	100%
In ethanol at 80℃; for 2h;	94%
In ethanol for 0.5h; Reflux;	92.4%

: 1122-62-9
2-acetylpyridine

: 34413-88-2
pinocarvone

: (1S,5R)-6,6-Dimethyl-2-(3-oxo-3-pyridin-2-yl-propyl)-bicyclo[3.1.1]heptan-3-one

Conditions

Conditions	Yield
With sodium hydroxide for 0.166667h; Michael addition;	100%

: 1122-62-9
2-acetylpyridine

: 5832-54-2
2-methylene-3-quinuclidinone hydrochloride

: 2-(3-oxo-3-pyridin-2-yl-propyl)-1-aza-bicyclo[2.2.2]octan-3-one

Conditions

Conditions	Yield
With sodium hydroxide for 10h; Michael addition;	100%

: 1122-62-9
2-acetylpyridine

: 3-methylene-2-norbornanone

: (1R,4S)-3-(3-Oxo-3-pyridin-2-yl-propyl)-bicyclo[2.2.1]heptan-2-one

Conditions

Conditions	Yield
With sodium hydroxide for 0.0833333h; Michael addition;	100%

: 1122-62-9
2-acetylpyridine

: 19501-58-7
4-methoxyphenylhydrazine hydrochloride

: 95526-07-1
N-(4-Methoxy-phenyl)-N'-[1-pyridin-2-yl-eth-(E)-ylidene]-hydrazine

Conditions

Conditions	Yield
In tert-butyl alcohol for 5h; Heating;	100%

: 1122-62-9
2-acetylpyridine

: 3132-99-8
m-bromobenzoic aldehyde

: 29816-74-8
(E)-3-(3-bromophenyl)-1-phenyl-2-propen-1-one

Conditions

Conditions	Yield
With sodium hydroxide In methanol	100%

: 27578-60-5
1-(2-aminoethyl)piperidine

: 1122-62-9
2-acetylpyridine

: 1314913-23-9
[(2-(piperidin-1-yl)-N-(1-(pyridin-2-yl)ethylidene)ethanamine)]

Conditions

Conditions	Yield
In methanol at 20℃; for 0.5h;	100%
In methanol

: 1122-62-9
2-acetylpyridine

: 618-40-6
1-Methyl-1-phenylhydrazine

: C14H15N3

Conditions

Conditions	Yield
In ethanol for 6h; Reflux;	100%

: 1122-62-9
2-acetylpyridine

: 4231-74-7
N-methyl-N-(pyridin-2-yl)hydrazine

: C13H14N4

Conditions

Conditions	Yield
In ethanol for 6h; Reflux;	100%

: 1483-24-5
1-methyl-1-benzoylhydrazine

: 1122-62-9
2-acetylpyridine

: C15H15N3O

Conditions

Conditions	Yield
In ethanol for 6h; Reflux;	100%

: 1122-62-9
2-acetylpyridine

: 4-(dimethylamino)-N-methylbenzohydrazide

: C17H20N4O

Conditions

Conditions	Yield
In ethanol for 6h; Reflux;	100%

: 1122-62-9
2-acetylpyridine

: 916322-38-8
1-η**(5)-ferrocenyl-3,3-bis(methylthio)prop-2-en-1-one

: C21H19FeNO2S

Conditions

Conditions	Yield
Stage #1: 2-acetylpyridine With sodium hydride In N,N-dimethyl-formamide; mineral oil; benzene at 0℃; for 0.75h; Inert atmosphere; Stage #2: 3,3-bis(methylsulfanyl)-1-η5-ferrocenyl-2-propen-1-one In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; benzene at 0 - 20℃; for 8h; Inert atmosphere;	100%

: 1122-62-9
2-acetylpyridine

: 40086-66-6
2-Bromoacetylpyridine

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid; pyridinium hydrobromide perbromide at 60℃; for 6h; Cooling;	99.67%
With pol(vinylphenyltrimethylammoniumtribromide) resin In methanol; water at 65℃; for 1h;	96%
With hydrogen bromide; bromine; acetic acid for 24h;	91%

: 1122-62-9
2-acetylpyridine

: 59042-90-9
(1S)-1-(2-pyridyl)ethanol

Conditions

Conditions	Yield
With C60H60P2Rh(1+)*BF4(1-); hydrogen In dichloromethane at 20℃; under 6080.41 Torr; for 24h; Solvent; Autoclave; enantioselective reaction;	99%
With Triisopropyl borate; potassium tert-butylate; hydrogen; trans-RuCl2[(R)-xylbinap][(R)-daipen] In isopropyl alcohol; tert-butyl alcohol at 25℃; under 6080.41 Torr; for 3h; Catalytic hydrogenation;	96%
With formic acid; C29H38N3O2RuS; triethylamine at 40℃; for 2h; Time; Inert atmosphere; enantioselective reaction;	96%

: 1122-62-9
2-acetylpyridine

: 1950-68-1
4-methoxybenzenesulfonyl hydrazide

: 4-methoxy-N'-(1-pyridin-2-ylethylidene)benzenesulfonylhydrazide

Conditions

Conditions	Yield
With silica gel In methanol for 0.0666667h; microwave irradiation;	99%

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 1122-62-9
2-acetylpyridine

: 1310040-01-7
(2-morpholin-4-ylethyl)-(1-pyridin-2-ylethylidene)amine

Conditions

Conditions	Yield
In methanol for 0.5h; Reflux;	99%
In ethanol for 2h; Reflux;	61.5%
In methanol

: 1122-62-9
2-acetylpyridine

: 7175-47-5
4-methylphenyl isocyanide

: C15H14N2O

Conditions

Conditions	Yield
With potassium carbonate; 1,3-bis(mesityl)imidazolium chloride In N,N-dimethyl acetamide at 80℃; for 12h;	99%

: 1122-62-9
2-acetylpyridine

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

: 2-(1-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy)ethyl)pyridine

Conditions

Conditions	Yield
With C84H110N10Zn2 In neat (no solvent) at 20℃; for 6h; Sealed tube; Inert atmosphere; Schlenk technique; Glovebox;	99%
With [((2,6-iPr2-C6H3)NC(Me)CHP(Cy2)N(2,6-Me2-C6H3))MgH]2; methyltriphenylsilane In benzene-d6 at 25℃; Catalytic behavior; chemoselective reaction;	96%
With C14H24N4Si(1+)*I(1-) In benzene-d6 at 90℃; for 7h; Catalytic behavior; Inert atmosphere; Schlenk technique; regioselective reaction;	91%

: 1122-62-9
2-acetylpyridine

: C18H12BrF3N2O4S

: (S)-3-(5-bromo-1-tosyl-1H-indol-3-yl)-4,4,4-trifluoro-3-(nitromethyl)-1-(pyridin-2-yl)butan-1-one

Conditions

Conditions	Yield
With C28H29N3O; cobalt(II) aceylacetonate In tert-butyl methyl ether at 20℃; for 24h; Michael Addition; Schlenk technique; Inert atmosphere; enantioselective reaction;	99%

: 1122-62-9
2-acetylpyridine

: 775-12-2
diphenylsilane

: C26H26N2O2Si

Conditions

Conditions	Yield
With C84H110N10Zn2 In neat (no solvent) at 20℃; for 12h; Sealed tube; Inert atmosphere; Schlenk technique; Glovebox;	99%
With N-(1-[5'-methyl-2,2'-bipyridin-6-yl]ethylidene)-2,4,6-trimethylbenzenamineiron(II) bromide; sodium triethylborohydride In tetrahydrofuran; toluene at 20℃; for 0.5h; Schlenk technique; Inert atmosphere;

: 1122-62-9
2-acetylpyridine

: C7H7(2)H2NO

Conditions

Conditions	Yield
With d8-isopropanol; [Ir(1-(1′-methylpyrazole)-3-(4′-methylphenyl)triazenide)Cp*Cl]; potassium hydroxide at 90℃; for 39h; Catalytic behavior; Reagent/catalyst; Inert atmosphere; Glovebox;	99%

: 1122-62-9
2-acetylpyridine

: 99-61-6
3-nitro-benzaldehyde

: 16232-04-5, 92905-89-0
(E)-3-(3-nitrophenyl)-1-(pyridin-2-yl)prop-2-en-1-one

Conditions

Conditions	Yield
With sodium carbonate In water at 70℃; for 1.5h;	98%
With potassium hydroxide In methanol; water at 0℃; for 3h;	93%
With sodium hydroxide In methanol; water at 0℃; Claisen-Schmidt Condensation;	80%

: 1122-62-9
2-acetylpyridine

: 555-16-8
4-nitrobenzaldehdye

: 18451-69-9
(2E)-3-(4-nitrophenyl)-1-(pyridin-2-yl)prop-2-en-1-one

Conditions

Conditions	Yield
With sodium carbonate In water at 70℃; for 0.5h;	98%
With sodium hydroxide In ethanol at 0℃; for 2h;	88%
With potassium hydroxide In methanol; water at 0℃; for 3h;	82%

2-Acetylpyridine Chemical Properties

Molecular Structure of 2-Acetylpyridine (CAS NO.1122-62-9):

IUPAC Name: 1-Pyridin-2-ylethanone
Molecular Formula: C₇H₇NO
Molecular Weight: 121.13
EINECS: 214-355-6
FEMA: 3251
XLogP3: 0.9
H-Bond Donor: 0
H-Bond Acceptor: 2
Melting Point: 8-10 °C
Index of Refraction: 1.513
Molar Refractivity: 34.37 cm³
Molar Volume: 114.1 cm³
Surface Tension: 39.6 dyne/cm
Density: 1.06 g/cm³
Flash Point: 73.3 °C
Enthalpy of Vaporization: 42.9 kJ/mol
Boiling Point: 192.8 °C at 760 mmHg
Vapour Pressure: 0.481 mmHg at 25 °C
Appearance: clear colorless to slightly brown liquid
Classification Code: Mutation data; Tumor data
Canonical SMILES: CC(=O)C1=CC=CC=N1
InChI: InChI=1S/C7H7NO/c1-6(9)7-4-2-3-5-8-7/h2-5H,1H3
InChIKey: AJKVQEKCUACUMD-UHFFFAOYSA-N
Product Categories: ACETYLGROUP; Carbonyl Compounds; Heterocycles; Pyridines derivates; pyridine Flavor

2-Acetylpyridine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - wild	LD50	oral	1gm/kg (1000mg/kg)		Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
rat	LD50	oral	2280mg/kg (2280mg/kg)		Food and Cosmetics Toxicology. Vol. 13, Pg. 487, 1975.

2-Acetylpyridine Safety Profile

Moderately toxic by ingestion. Mutation data reported. A flammable liquid. When heated to decomposition it emits toxic vapors of NO_x.
Safety Information of 2-Acetylpyridine (CAS NO.1122-62-9):
Hazard Codes: Irritant Xi
Risk Statements: 36/37/38-38
R36/37/38:Irritating to eyes, respiratory system and skin.
R38:Irritating to skin.
Safety Statements: 26-36-37
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37:Wear suitable gloves.
WGK Germany: 3
RTECS: OB5310000
F: 8
Hazard Note: Irritant

2-Acetylpyridine Standards and Recommendations

DOT Classification: 3; Label: Flammable Liquid

2-Acetylpyridine Specification

2-Acetylpyridine (CAS NO.1122-62-9), its Synonyms are 1-(2-Pyridinyl)ethanone ; 2-Acetylpyridine (natural) ; 2-Pyridyl methyl ketone ; Ketone, methyl 2-pyridyl ; Methyl 2-pyridyl ketone ; Ethanone, 1-(2-pyridinyl)- .

Product Name

2-Acetylpyridine

Synthetic route

2-Acetylpyridine Chemical Properties

2-Acetylpyridine Toxicity Data With Reference

2-Acetylpyridine Safety Profile

2-Acetylpyridine Standards and Recommendations

2-Acetylpyridine Specification

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