2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone supplier

Name
2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone
EINECS 812-641-0
CAS No. 204205-33-4
Article Data21
CAS DataBase
Density 1.574 g/cm³
Solubility
Melting Point
Formula C₁₁H₁₀BrFO
Boiling Point 293.012 °C at 760 mmHg
Molecular Weight 257.102
Flash Point 131.009 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 2-Bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone;Ethanone,2-bromo-1-cyclopropyl-2-(2-fluorophenyl)-;a-(Cyclopropylcarbonyl)-2-fluorobenzyl bromide;
PSA 17.07000
LogP 3.24080

Synthetic route

: 150322-73-9
1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions

Conditions	Yield
With iodine(I) bromide; 1-n-butyl-3-methylimidazolim bromide In tetrahydrofuran at 40℃; for 4h; Temperature; Time; Concentration;	95.3%
With bromine In methanol at 25 - 30℃; for 6h; Concentration;	94.65%
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; 2,2'-azobis(isobutyronitrile) In cyclohexane at 10℃; Product distribution / selectivity; Reflux;	93.28%

: 451-82-1
(2-fluorophenyl)acetic acid

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: triethylamine / dichloromethane / 0.25 h / 0 - 5 °C 1.2: 6 h / 0 - 5 °C 2.1: iodine; magnesium / tetrahydrofuran / 25 - 50 °C 2.2: 40 - 50 °C 2.3: 0.25 h / 0 - 30 °C 3.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux View Scheme
Multi-step reaction with 2 steps 1.1: magnesium; isopropyl bromide / toluene; tetrahydrofuran / 15 - 65 °C 1.2: 5 - 65 °C 2.1: dibenzoyl peroxide; N-Bromosuccinimide / ethyl acetate / 25 - 60 °C View Scheme
Multi-step reaction with 2 steps 1.1: magnesium; isopropyl bromide / toluene; tetrahydrofuran / 15 - 65 °C 1.2: 5 - 65 °C 2.1: dibenzoyl peroxide; N-Bromosuccinimide / ethyl acetate / 25 - 60 °C View Scheme
Multi-step reaction with 2 steps 1: sodium hydride / toluene; dimethyl sulfoxide / 1.5 h / 95 - 110 °C / Large scale 2: bromine / methanol / Large scale View Scheme

: 946402-23-9
2-(2-fluorophenyl)-N-methoxy-N-methylacetamide

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: iodine; magnesium / tetrahydrofuran / 25 - 50 °C 1.2: 40 - 50 °C 1.3: 0.25 h / 0 - 30 °C 2.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux View Scheme
Multi-step reaction with 2 steps 1.1: iodine; magnesium / tetrahydrofuran / 40 - 50 °C 1.2: 0.25 h / 0 - 30 °C 2.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / toluene-4-sulfonic acid / dichloromethane / 4.75 h / 0 - 5 °C / Reflux View Scheme

: 345-35-7
2-fluorobenzyl chloride

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: tetrabutylammomium bromide / dichloromethane; water / 25 °C 2.1: sodium hydroxide; water / 5 - 95 °C 2.2: pH 2 - 3 3.1: magnesium; isopropyl bromide / toluene; tetrahydrofuran / 15 - 65 °C 3.2: 5 - 65 °C 4.1: dibenzoyl peroxide; N-Bromosuccinimide / ethyl acetate / 25 - 60 °C View Scheme
Multi-step reaction with 4 steps 1.1: tetrabutylammomium bromide / dichloromethane; water / 25 °C 2.1: sodium hydroxide; water / 5 - 95 °C 2.2: pH 2 - 3 3.1: magnesium; isopropyl bromide / toluene; tetrahydrofuran / 15 - 65 °C 3.2: 5 - 65 °C 4.1: dibenzoyl peroxide; N-Bromosuccinimide / ethyl acetate / 25 - 60 °C View Scheme
Multi-step reaction with 2 steps 1: magnesium; iodine / tetrahydrofuran; 2-methyltetrahydrofuran / 1.5 h / 40 - 45 °C / Inert atmosphere 2: N-Bromosuccinimide; toluene-4-sulfonic acid / acetonitrile / 24 h / 40 °C View Scheme
Multi-step reaction with 2 steps 1: magnesium; iodine / tetrahydrofuran; toluene / 1.5 h / 40 - 45 °C / Inert atmosphere 2: N-Bromosuccinimide; toluene-4-sulfonic acid / acetonitrile / 24 h / 40 °C View Scheme

: 326-62-5
2-fluorophenyl acetonitrile

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: sodium hydroxide; water / 5 - 95 °C 1.2: pH 2 - 3 2.1: magnesium; isopropyl bromide / toluene; tetrahydrofuran / 15 - 65 °C 2.2: 5 - 65 °C 3.1: dibenzoyl peroxide; N-Bromosuccinimide / ethyl acetate / 25 - 60 °C View Scheme
Multi-step reaction with 3 steps 1.1: sodium hydroxide; water / 5 - 95 °C 1.2: pH 2 - 3 2.1: magnesium; isopropyl bromide / toluene; tetrahydrofuran / 15 - 65 °C 2.2: 5 - 65 °C 3.1: dibenzoyl peroxide; N-Bromosuccinimide / ethyl acetate / 25 - 60 °C View Scheme

: 4606-07-9
ethyl cyclopropylcarboxylate

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions

Conditions	Yield
Stage #1: With iodine; magnesium; isopropyl bromide In tetrahydrofuran at 65℃; for 3h; Stage #2: ethyl cyclopropylcarboxylate In tetrahydrofuran at 5 - 70℃; for 3.16667h; Stage #3: With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); toluene-4-sulfonic acid In chloroform at 28 - 65℃; for 4h;

: 2-(2-fluorophenyl acetic acid)

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: triethylamine / dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 6 h / 0 - 5 °C 2.1: iodine; magnesium / tetrahydrofuran / 40 - 50 °C 2.2: 0.25 h / 0 - 30 °C 3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / toluene-4-sulfonic acid / dichloromethane / 4.75 h / 0 - 5 °C / Reflux View Scheme

: 462-06-6
fluorobenzene

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: tin(IV) chloride / tetrahydrofuran / 4 h / 45 °C 2: dichloromethane / 4 h / 20 °C 3: bromine / tetrahydrofuran / 10 h / 20 °C View Scheme

: 57486-67-6
methyl o-fluorophenylacetate

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: pyridine / tetrahydrofuran / 6 h / 20 - 60 °C 2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 8 h / 20 °C View Scheme

: 446-48-0
o-fluorobenzyl bromide

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: magnesium / methyl iodide / diethyl ether / 20 °C 1.2: 20 °C 1.3: 0 °C 2.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; 2,2'-azobis(isobutyronitrile) / cyclohexane / 10 °C / Reflux View Scheme

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: 150322-38-6
5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one

Conditions

Conditions	Yield
With ammonium bicarbonate In dichloromethane at 5 - 20℃;	98%
With copper(l) iodide; sodium carbonate; XPhos In 1,4-dioxane at 60℃; for 3h; Reagent/catalyst; Temperature; Inert atmosphere;	90.2%
With potassium phosphate; iodine In 1,4-dioxane at 80℃; for 4h; Temperature; Time; Reagent/catalyst;	87.6%

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 57-06-7
N-allyl isothiocyanate

: 589-16-2
4-aminoethylbenzene

: 3-allyl-2-(4'-ethylphenylimino)-4-cyclopropyl-5-(2'-fluorophenyl)-thiazole

Conditions

Conditions	Yield
With polyvinyl pyridine (PVP) In ethanol at 20℃; for 18h; regioselective reaction;	96%
With 1-octyl-3-methylimidazole hexafluorophosphate at 20℃; for 1h; regioselective reaction;	96%

...Expand

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 133477-39-1
2-[1-(2-naphthenyl)ethyledene]hydrazinecarbothioamide

: 4-cyclopropyl-5-(2-fluorophenyl)-2-((1-(naphthalen-2-yl)ethylidene)hydrazono)-2,3-dihydrothiazole

Conditions

Conditions	Yield
With triethylamine In ethanol for 0.333333h; Hantzsch Thiazole Synthesis; Reflux;	96%

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 106-49-0
p-toluidine

: 57-06-7
N-allyl isothiocyanate

: 3-allyl-2-(4'-methylphenylimino)-4-cyclopropyl-5-(2'-fluorophenyl)-thiazole

Conditions

Conditions	Yield
With polyvinyl pyridine (PVP) In ethanol at 20℃; for 20h; Reagent/catalyst; Temperature; Time; regioselective reaction;	95%
With 1-octyl-3-methylimidazole hexafluorophosphate at 20℃; for 1h; regioselective reaction;	95%

...Expand

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 156-43-4
4-Ethoxyaniline

: 57-06-7
N-allyl isothiocyanate

: 3-allyl-2-(4'-ethoxylphenylimino)-4-cyclopropyl-5-(2'-fluorophenyl)-thiazole

Conditions

Conditions	Yield
With polyvinyl pyridine (PVP) In ethanol at 20℃; for 14h; regioselective reaction;	95%

...Expand

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 304458-95-5
6-methoxy-tetral-4-one thiosemicarbazone

: 4-cyclopropyl-5-(2-fluorophenyl)-2-((6-methoxy-3,4-dihydronaphthalen-1(2H)-ylidene)hydrazono)-2,3-dihydrothiazole

Conditions

Conditions	Yield
With triethylamine In ethanol for 0.5h; Reagent/catalyst; Solvent; Temperature; Hantzsch Thiazole Synthesis; Reflux;	95%

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 156-43-4
4-Ethoxyaniline

: 57-06-7
N-allyl isothiocyanate

: 3-allyl-2-(4'-ethoxylphenylimino)-4-cyclopropyl-5-(2'-fluoro-phenyl)-thiazole

Conditions

Conditions	Yield
With 1-octyl-3-methylimidazole hexafluorophosphate at 20℃; for 0.75h; regioselective reaction;	95%

...Expand

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 3689-17-6
2-(3,4-dihydronaphthalen-1(2H)-ylidene)hydrazinecarbothioamide

: 4-cyclopropyl-2-((3,4-dihydronaphthalen-1(2H)-ylidene)hydrazono)-5-(2-fluorophenyl)-2,3-dihydrothiazole

Conditions

Conditions	Yield
With triethylamine In ethanol for 0.5h; Hantzsch Thiazole Synthesis; Reflux;	94%

: 5382-16-1
4-HYDROXYPIPERIDINE

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 1-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4-hydroxypiperidine

Conditions

Conditions	Yield
With potassium carbonate In N-methyl-acetamide; water	93%
With potassium carbonate In N-methyl-acetamide; water	93%

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 1263407-24-4
(5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)boronic acid

Conditions

Conditions	Yield
Stage #1: C7H10BNO2S*C7H8O3S With triethylamine In ethanol at 50℃; Inert atmosphere; Stage #2: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone In ethanol at 50℃; for 8h;	93%

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 1563931-94-1
3-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)thiazolidine-2,4-dione

Conditions

Conditions	Yield
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 20℃; for 6h;	93%

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 104-94-9
4-methoxy-aniline

: 556-61-6
methyl thioisocyanate

: 3-methyl-2-(4'-methoxyphenylimino)-4-cyclopropyl-5-(2'-fluorophenyl)-thiazole

Conditions

Conditions	Yield
With polyvinyl pyridine (PVP) In ethanol at 20℃; for 16h; regioselective reaction;	93%
With 1-octyl-3-methylimidazole hexafluorophosphate at 20℃; for 1.5h; regioselective reaction;	93%

...Expand

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 74227-66-0
1-indanone thiosemicarbazone

: 4-cyclopropyl-2-((2,3-dihydro-1H-inden-1-ylidene)hydrazono)-5-(2-fluorophenyl)-2,3-dihydrothiazole

Conditions

Conditions	Yield
With triethylamine In ethanol for 0.333333h; Hantzsch Thiazole Synthesis; Reflux;	93%

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 542-85-8
Ethyl isothiocyanate

: 589-16-2
4-aminoethylbenzene

: 3-ethyl-2-(4'-ethylphenylimino)-4-cyclopropyl-5-(2'-fluorophenyl)-thiazole

Conditions

Conditions	Yield
With polyvinyl pyridine (PVP) In ethanol at 20℃; for 14h; regioselective reaction;	92%
With 1-octyl-3-methylimidazole hexafluorophosphate at 20℃; for 1.5h; regioselective reaction;	92%

...Expand

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 542-85-8
Ethyl isothiocyanate

: 156-43-4
4-Ethoxyaniline

: 3-ethyl-2-(4'-ethoxyphenylimino)-4-cyclopropyl-5-(2'-fluoro-phenyl)-thiazole

Conditions

Conditions	Yield
With polyvinyl pyridine (PVP) In ethanol at 20℃; for 12h; regioselective reaction;	91%
With 1-octyl-3-methylimidazole hexafluorophosphate at 20℃; for 2h; regioselective reaction;	91%

...Expand

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 16546-08-0
1-(1-(4-methoxyphenyl)ethylidene)thiosemicarbazide

: 4-cyclopropyl-5-(2-fluorophenyl)-2-(2-(1-(4-methoxyphenyl)ethylidene)hydrazinyl)thiazole

Conditions

Conditions	Yield
With triethylamine In ethanol for 0.583333h; Hantzsch Thiazole Synthesis; Reflux;	91%

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 109904-37-2
5,6,7,7a-tetrahydrothieno[3,2-c]pyridine-2(4H)-one monohydrochloride

: 18162-48-6
tert-butyldimethylsilyl chloride

: 952340-38-4
2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Conditions

Conditions	Yield
Stage #1: 5,6,7,7a-tetrahydrothieno[3,2-c]pyridine-2(4H)-one monohydrochloride With triethylamine In dichloromethane at 10℃; for 0.25h; Stage #2: tert-butyldimethylsilyl chloride In dichloromethane at 10℃; Stage #3: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone With triethylamine; sodium iodide In dichloromethane at 10 - 25℃; Temperature;	90%

...Expand

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 71173-46-1
1-(1-(3,4-dimethoxyphenyl)ethylidene)thiosemicarbazide

: 4-cyclopropyl-2-((1-(3,4-dimethoxyphenyl)ethylidene)hydrazono)-5-(2-fluorophenyl)-2,3-dihydrothiazole

Conditions

Conditions	Yield
With triethylamine In ethanol for 0.666667h; Hantzsch Thiazole Synthesis; Reflux;	90%

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 104-94-9
4-methoxy-aniline

: 57-06-7
N-allyl isothiocyanate

: 3-allyl-2-(4'-methoxyphenylimino)-4-cyclopropyl-5-(2'-fluorophenyl)-thiazole

Conditions

Conditions	Yield
With polyvinyl pyridine (PVP) In ethanol at 20℃; for 16h; regioselective reaction;	89%
With 1-octyl-3-methylimidazole hexafluorophosphate at 20℃; for 0.75h; regioselective reaction;	89%

...Expand

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 7410-54-0
2-(1-(4-tolyl)ethylidene)hydrazinecarbothioamide

: 4-cyclopropyl-5-(2-fluorophenyl)-2-((1-(p-tolyl)ethylidene)hydrazono)-2,3-dihydrothiazole

Conditions

Conditions	Yield
With triethylamine In ethanol for 0.583333h; Hantzsch Thiazole Synthesis; Reflux;	89%

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 106-40-1
4-bromo-aniline

: 57-06-7
N-allyl isothiocyanate

: 3-allyl-2-(4'-bromophenylimino)-4-cyclopropyl-5-(2'-fluorophenyl)-thiazole

Conditions

Conditions	Yield
With polyvinyl pyridine (PVP) In ethanol at 20℃; for 20h; regioselective reaction;	88%
With 1-octyl-3-methylimidazole hexafluorophosphate at 20℃; for 1.25h; regioselective reaction;	88%

...Expand

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 5424-45-3
2-[1-(4-nitrophenyl)ethylidene]hydrazine-1-carbothioamide

: 4-cyclopropyl-5-(2-fluorophenyl)-2-((1-(4-nitrophenyl)ethylidene)hydrazono)-2,3-dihydrothiazole

Conditions

Conditions	Yield
With triethylamine In ethanol for 0.5h; Hantzsch Thiazole Synthesis; Reflux;	88%

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: C8H14BrNO2S

: C19H23BrFNO3S

Conditions

Conditions	Yield
With potassium phosphate; iodine at 80℃; for 7h; Temperature; Reagent/catalyst;	87.1%

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 536-90-3
m-Anisidine

: 57-06-7
N-allyl isothiocyanate

: 3-allyl-2-(3'-methoxyphenylimino)-4-cyclopropyl-5-(2'-fluoro-phenyl)-thiazole

Conditions

Conditions	Yield
With polyvinyl pyridine (PVP) In ethanol at 20℃; for 18h; regioselective reaction;	87%
With 1-octyl-3-methylimidazole hexafluorophosphate at 20℃; for 1h; regioselective reaction;	87%

...Expand

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 106-47-8
4-chloro-aniline

: 57-06-7
N-allyl isothiocyanate

: 3-allyl-2-(4'-chlorophenylimino)-4-cyclopropyl-5-(2'-fluorophenyl)-thiazole

Conditions

Conditions	Yield
With polyvinyl pyridine (PVP) In ethanol at 20℃; for 20h; regioselective reaction;	87%
With 1-octyl-3-methylimidazole hexafluorophosphate at 20℃; for 1.25h; regioselective reaction;	87%

...Expand

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 123-30-8
4-amino-phenol

: 57-06-7
N-allyl isothiocyanate

: 3-allyl-2-(4'-hydroxyphenylimino)-4-cyclopropyl-5-(2'-fluorophenyl)-thiazole

Conditions

Conditions	Yield
With polyvinyl pyridine (PVP) In ethanol at 20℃; for 24h; regioselective reaction;	82%
With 1-octyl-3-methylimidazole hexafluorophosphate at 20℃; for 1h; regioselective reaction;	82%

...Expand

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: (E)-4-(acetylsulfanyl)-3-((1-[(2-pyridyl)methyl]-1H-pyrazol-3-yl)methylidene)piperidine bis(hydrogen trifluoroacetate)

: (E)-4-(acetylsulfanyl)-1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-3-((1-[(2-pyridyl)methyl]-1H-pyrazol-3-yl)methylidene)piperidine

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 20℃; for 0.5h;	81%

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 853805-52-4
(E)-4-(acetylsulfanyl)-3-((1-[3-(ethoxycarbonyl)propyl]-1H-1,2,3-triazol-4-yl)methylidene)piperidine hydrogen trifluoroacetate

: (E)-4-(acetylsulfanyl)-1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-3-((1-[3-(ethoxycarbonyl)propyl]-1H-1,2,3-triazol-4-yl)methylidene)piperidine

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 20℃; for 2.5h;	77%

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: (E)-3-[(furan-2-yl)methylidene]piperidin-4-ol hydrogen acetate

: (E)-1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-3-[(furan-2-yl)methylidene]piperidin-4-ol

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 0 - 20℃; for 1h;	74%

2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone Chemical Properties

Molecule structure of 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone (CAS NO.204205-33-4):

Molecular Formula: C₁₁H₁₀BrFO
Molecular Weight: 257.10 g/mol
Density: 1.574 g/cm³
Boiling Point: 293.012 °C at 760 mmHg
Flash Point: 131.009 °C
Index of Refraction: 1.592
Molar Refractivity: 55.256 cm³
Molar Volume: 163.331 cm³
Polarizability: 21.905×10^-24 cm³
Surface Tension: 50.662 dyne/cm
Enthalpy of Vaporization: 53.255 kJ/mol
Vapour Pressure: 0.002 mmHg at 25 °C
InChI: InChI=1/C11H10BrFO/c12-10(11(14)7-5-6-7)8-3-1-2-4-9(8)13/h1-4,7,10H,5-6H2
InChIKey of 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone (CAS NO.204205-33-4): LMCZCCDXOZGIND-UHFFFAOYAC

2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone Specification

2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone (CAS NO.204205-33-4) is also named as 2-Bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone ; ethanone, 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)- .

Product Name

2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone

Synthetic route

2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone Chemical Properties

2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone Specification

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