Product Name

  • Name

    2-Chloroethyl chloroformate

  • EINECS 210-982-4
  • CAS No. 627-11-2
  • Article Data25
  • CAS DataBase
  • Density 1.37 g/cm3
  • Solubility
  • Melting Point -70oC BOLING
  • Formula C3H4Cl2O2
  • Boiling Point 156.9 °C at 760 mmHg
  • Molecular Weight 142.97
  • Flash Point 59.8 °C
  • Transport Information
  • Appearance Liquid
  • Safety 26-36/37/39-45
  • Risk Codes 23-34
  • Molecular Structure Molecular Structure of 627-11-2 (2-Chloroethyl chloroformate)
  • Hazard Symbols ToxicT
  • Synonyms Formicacid, chloro-, 2-chloroethyl ester (6CI,7CI,8CI);(2-Chloroethoxy)carbonylchloride;2-Chloroethyl carbonochloridate;Chloroformic acid 2-chloroethyl ester;b-Chloroethyl chloroformate;
  • PSA 26.30000
  • LogP 1.60060

Synthetic route

phosgene
75-44-5

phosgene

2-chloro-ethanol
107-07-3

2-chloro-ethanol

2-Chloroethyl chloroformate
627-11-2

2-Chloroethyl chloroformate

Conditions
ConditionsYield
at 10 - 25℃; for 2.5h;97%
at 0℃;
With water; calcium carbonate at 0℃;
oxirane
75-21-8

oxirane

pyridine
110-86-1

pyridine

phosgene
75-44-5

phosgene

A

chloroethyl carbonate
623-97-2

chloroethyl carbonate

B

2-Chloroethyl chloroformate
627-11-2

2-Chloroethyl chloroformate

oxirane
75-21-8

oxirane

phosgene
75-44-5

phosgene

2-Chloroethyl chloroformate
627-11-2

2-Chloroethyl chloroformate

Conditions
ConditionsYield
With ethyl bromide
With pyridine
With hydrogenchloride at 150℃;
phosgene
75-44-5

phosgene

2-chloroethyl nitrite
10288-17-2

2-chloroethyl nitrite

2-Chloroethyl chloroformate
627-11-2

2-Chloroethyl chloroformate

Conditions
ConditionsYield
at 65℃; unter Druck;
at 65℃; unter Druck;
ethylenebis(chloroformate)
124-05-0

ethylenebis(chloroformate)

A

1,1-dichloroethane
75-34-3

1,1-dichloroethane

B

Vinyl chloroformate
5130-24-5

Vinyl chloroformate

C

carbonochloridic acid 1-chloro-ethyl ester
50893-53-3

carbonochloridic acid 1-chloro-ethyl ester

D

2-Chloroethyl chloroformate
627-11-2

2-Chloroethyl chloroformate

Conditions
ConditionsYield
at 460℃; Produkt 5: 1.2-Dichlor-aethan.Pyrolysis;
2-chloroethyl nitrite
10288-17-2

2-chloroethyl nitrite

trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

2-Chloroethyl chloroformate
627-11-2

2-Chloroethyl chloroformate

2-chloroethyl nitrite
10288-17-2

2-chloroethyl nitrite

trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

A

chloroethyl carbonate
623-97-2

chloroethyl carbonate

B

2-Chloroethyl chloroformate
627-11-2

2-Chloroethyl chloroformate

[1,3]-dioxolan-2-one
96-49-1

[1,3]-dioxolan-2-one

2-Chloroethyl chloroformate
627-11-2

2-Chloroethyl chloroformate

Conditions
ConditionsYield
With phosphorus pentachloride
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

2-chloro-ethanol
107-07-3

2-chloro-ethanol

2-Chloroethyl chloroformate
627-11-2

2-Chloroethyl chloroformate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0 - 20℃; for 0.5h;
2-chloro-ethanol
107-07-3

2-chloro-ethanol

2-Chloroethyl chloroformate
627-11-2

2-Chloroethyl chloroformate

N-benzyl-4-chlorobenzenesulfonamide
10504-90-2

N-benzyl-4-chlorobenzenesulfonamide

potassium carbonate
584-08-7

potassium carbonate

2-Chloroethyl chloroformate
627-11-2

2-Chloroethyl chloroformate

2-chloroethyl N-(p-chlorobenzenesulfonyl) N-benzyl carbamate
52001-78-2

2-chloroethyl N-(p-chlorobenzenesulfonyl) N-benzyl carbamate

Conditions
ConditionsYield
In water; acetone100%
1-pentanamine
110-58-7

1-pentanamine

2-Chloroethyl chloroformate
627-11-2

2-Chloroethyl chloroformate

2-chloroethyl pentylcarbamate
98997-81-0

2-chloroethyl pentylcarbamate

Conditions
ConditionsYield
In hexane at 0 - 20℃; for 1.5h;99%
With benzene
2-Chloroethyl chloroformate
627-11-2

2-Chloroethyl chloroformate

benzylamine
100-46-9

benzylamine

2-chloroethyl N-benzylcarbamate
412308-23-7

2-chloroethyl N-benzylcarbamate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0℃; for 0.5h;99%
With benzene
(S)-1-phenyl-ethylamine
2627-86-3

(S)-1-phenyl-ethylamine

2-Chloroethyl chloroformate
627-11-2

2-Chloroethyl chloroformate

2-chloroethyl (S)-N-(1-phenylethyl)carbamate

2-chloroethyl (S)-N-(1-phenylethyl)carbamate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0℃; for 0.5h;99%
3,5-dimethyl-4-(3-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)aniline hydrochloride

3,5-dimethyl-4-(3-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)aniline hydrochloride

2-Chloroethyl chloroformate
627-11-2

2-Chloroethyl chloroformate

C17H19ClF3N3O2

C17H19ClF3N3O2

Conditions
ConditionsYield
With pyridine In dichloromethane at -8℃; for 2h; Temperature; Large scale;99%
n-Octylamine
111-86-4

n-Octylamine

2-Chloroethyl chloroformate
627-11-2

2-Chloroethyl chloroformate

2-chloroethyl octylcarbamate
99993-44-9

2-chloroethyl octylcarbamate

Conditions
ConditionsYield
In hexane at 0 - 20℃; for 1.5h;98%
2-Chloroethyl chloroformate
627-11-2

2-Chloroethyl chloroformate

2-methyl-4-nitro-benzenamine
99-52-5

2-methyl-4-nitro-benzenamine

3-(2-methyl-4-nitrophenyl)-1,3-oxazolidin-2-one
444002-92-0

3-(2-methyl-4-nitrophenyl)-1,3-oxazolidin-2-one

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran at 0 - 20℃; for 14h; Reflux;96%
2-Chloroethyl chloroformate
627-11-2

2-Chloroethyl chloroformate

But-3-ynyl-[1-[1-(4-methoxy-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-meth-(E)-ylidene]-amine

But-3-ynyl-[1-[1-(4-methoxy-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-meth-(E)-ylidene]-amine

6-(4-Methoxy-benzenesulfonyl)-3,5,6,10c-tetrahydro-2H-pyrrolo[3,2-c]carbazole-1-carboxylic acid 2-chloro-ethyl ester

6-(4-Methoxy-benzenesulfonyl)-3,5,6,10c-tetrahydro-2H-pyrrolo[3,2-c]carbazole-1-carboxylic acid 2-chloro-ethyl ester

Conditions
ConditionsYield
With diisopropylamine In benzene at 80℃; for 1h;95%
2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-4,5-diamine hydrochloride
1354041-35-2

2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-4,5-diamine hydrochloride

2-Chloroethyl chloroformate
627-11-2

2-Chloroethyl chloroformate

C20H17ClFN7O3
1354041-82-9

C20H17ClFN7O3

Conditions
ConditionsYield
With pyridine In dichloromethane95%
Lorcaserin hydrochloride
846589-98-8

Lorcaserin hydrochloride

2-Chloroethyl chloroformate
627-11-2

2-Chloroethyl chloroformate

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine 3-carboxylic acid 2-chloroethyl ester

(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine 3-carboxylic acid 2-chloroethyl ester

Conditions
ConditionsYield
Stage #1: Lorcaserin hydrochloride With triethylamine In dichloromethane at 0℃; for 0.166667h;
Stage #2: 2-Chloroethyl chloroformate In dichloromethane at 0℃; for 2h;
94.5%
DL-tryptophan ethyl ester hydrochloride
6519-67-1

DL-tryptophan ethyl ester hydrochloride

2-Chloroethyl chloroformate
627-11-2

2-Chloroethyl chloroformate

N-<(chloroethoxy)carbonyl>-D,L-tryptophan ethyl ester

N-<(chloroethoxy)carbonyl>-D,L-tryptophan ethyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20 - 25℃; for 1.5h;94%
2-Chloroethyl chloroformate
627-11-2

2-Chloroethyl chloroformate

2-chloro-4-methyl-benzenamine
615-65-6

2-chloro-4-methyl-benzenamine

2-chloroethyl-N-[(4-chloro-2-methyl-5-nitro)phenyl]-carbamate
173552-30-2

2-chloroethyl-N-[(4-chloro-2-methyl-5-nitro)phenyl]-carbamate

Conditions
ConditionsYield
With calcium carbonate In 1,4-dioxane94%

2-CHLOROETHYL CHLOROFORMATE Chemical Properties

Chemical Name: 2-Chloroethyl chloroformate
IUPAC NAME: 2-chloroethyl carbonochloridate
CAS No.: 627-11-2
EINECS: 210-982-4
RTECS: LQ5950000
RTECS Class: Mutagen
Molecular Formula: : C3H4Cl2O2
Molecular Weight: 142.97 g/mol
Density: 1.385g/cm3
Melting Point: -48°C
Flash Point: 158°F
Boiling Point: 155-156°C
Storage temp.: Refrigerator
The liquid incompatible with strong oxidizing agents, alcohols, amines, alkali May react vigorously or explosively and the structure of 2-CHLOROETHYL CHLOROFORMATE(627-11-2) as follows:

                     
The chemical synonymous of 2-CHLOROETHYL CHLOROFORMATE(627-11-2) are 2-Chlorethylester kyseliny chlormravenci;2-chlorethylesterkyselinychlormravenci;2-chlorethylesterkyselinychlormravenci(czech);2-Chloroethyl chloridocarbonate;2-Chloroethyl chlorocarbonate;beta-chloroethylchlorocarbonate;Carbonochloridicacid,2-chloroethylester;Carbonochloridicacid2-chloroethylester

2-CHLOROETHYL CHLOROFORMATE Uses

 2-CHLOROETHYL CHLOROFORMATE(627-11-2) is a bactericide oxadixyl intermediates.it is used as a pharmaceutical, agrochemical intermediates and for synthesis of pesticides, perfumes, drugs, polymers, dyes, and other chemicals chloroformates.

2-CHLOROETHYL CHLOROFORMATE Production

Product Categories about 2-CHLOROETHYL CHLOROFORMATE(627-11-2) is mainly CHLOROFORMATES.

2-CHLOROETHYL CHLOROFORMATE Toxicity Data With Reference

1.   

ihl-mus LCLo:200 mg/m3/10M

   NDRC**    National Defense Research Committee, Office of Scientific Research and Development, Progress Report NCDrc-132,June ,1942.

2. mouse     LCLo     inhalation    200mg/m3/10M (200mg/m3)     National Defense Research Committee, Office of Scientific Research and Development, Progress Report.Vol. NDCrc-132, Pg. JUN1942,

2-CHLOROETHYL CHLOROFORMATE Consensus Reports

EPA Extremely Hazardous Substances List. EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.

2-CHLOROETHYL CHLOROFORMATE Safety Profile

Poison by inhalation. May also cause fatalities by ingestion or skin contact. May cause burns to the eyes and skin. When heated to decomposition it emits toxic fumes of Cl.
Health Hazard: (Non-Specific -- Ethyl Chloroformate) Poisonous; may be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes.
Hazard Codes:
    T: Toxic 
Risk Statements about  2-CHLOROETHYL CHLOROFORMATE(627-11-2):
    R23 Toxic by inhalation.
    R34 Causes burns.
Safety Statements about  2-CHLOROETHYL CHLOROFORMATE(627-11-2):
    S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    S45 In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
    S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.

2-CHLOROETHYL CHLOROFORMATE Standards and Recommendations

DOT Classification:  6.1; Label: Poison, Corrosive

2-CHLOROETHYL CHLOROFORMATE Specification

1. Storage: Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
2. Handling:All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
3. Personal Protection: Wear appropriate protective gloves, clothing and goggles.
4. Fire Fighting: Note: Most foams will react with the material and release corrosive/toxic gases. Small Fires: carbon dioxide, dry chemical, dry sand, alcohol-resistant foam. Large Fires: Water spray, fog or alcohol-resistant foam.
5. Air & Water Reactions: Decomposed slowly by water forming ethanol, HCl, and CO2; on contact with moist air, 2-Chloroethyl chloroformate gives off HCl fumes; attacks many metals especially in humid atmosphere. REF [Handling Chemicals Safely, 1980. p. 476].
6. Reactivity Profile: 2-Chloroethyl chloroformate is an acid halide. Acid halides are water reactive; some are violently reactive. They are incompatible with strong oxidizing agents, alcohols, amines, alkali. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

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