2-Furoic acid supplier | CasNO.88-14-2

Name
2-Furoic acid
EINECS 201-803-0
CAS No. 88-14-2
Article Data355
CAS DataBase
Density 1.322 g/cm³
Solubility 36 g/L (20 °C) in water
Melting Point -2 °C(lit.)
Formula C₅H₄O₃
Boiling Point 232.14 °C at 760 mmHg
Molecular Weight 112.085
Flash Point 94.195 °C
Transport Information UN 3265 8/PG 2
Appearance white to light yellow crystal powder
Safety 26-36/37/39-45
Risk Codes 34-36/37/38
Molecular Structure
Hazard Symbols C, Xi
Synonyms 2-Furoicacid (7CI,8CI);2-Carboxyfuran;NSC 58965;NSC 8842;Pyromucic acid;a-Furancarboxylic acid;a-Furoic acid;2-Furancarboxylicacid;
PSA 50.44000
LogP 0.97780

Synthetic route

: 611-13-2
2-furoic acid methyl ester

: 88-14-2
2-furanoic acid

Conditions

Conditions	Yield
With potassium carbonate; thiophenol In 1-methyl-pyrrolidin-2-one at 190℃; for 0.166667h; Substitution;	100%
With potassium fluoride; thiophenol In various solvent(s) at 190℃; for 0.166667h;	90%
With potassium fluoride; thiophenol In 1-methyl-pyrrolidin-2-one for 0.166667h; Heating;	90%

: 55790-00-6
furfural α-hydroxyhydroperoxide

: 88-14-2
2-furanoic acid

Conditions

Conditions	Yield
With pyridine at 24℃; for 0.25 - 0.333333h; Kinetics; Thermodynamic data; Reagent/catalyst;	100%

: 98-01-1
furfural

A: 98-00-0
(2-furyl)methyl alcohol

B: 88-14-2
2-furanoic acid

Conditions

Conditions	Yield
Stage #1: furfural With potassium hydroxide for 0.0833333h; Cannizzaro Reaction; Milling; Inert atmosphere; Sealed tube; Green chemistry; Stage #2: With hydrogenchloride In water for 0.0833333h; Green chemistry;	A 99% B 99%
With TEA; magnesium bromide In dichloromethane at 20℃; for 48h; Cannizzaro reaction;	A 90% B n/a
With sodium hydroxide In water at 0 - 20℃; for 12h; Reagent/catalyst; Cannizzaro Reaction;	A 88% B 83%

: 98-01-1
furfural

: 88-14-2
2-furanoic acid

Conditions

Conditions	Yield
With copper acetylacetonate; oxygen; sodium hydroxide; 1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene In water at 50℃; under 760.051 Torr; for 12h; Sealed tube;	99%
With 4H3N4H(1+)CuMo6O18(OH)6(4-); water; oxygen; sodium carbonate at 50℃; under 760.051 Torr; for 12h;	99%
With NADH oxidase and coniferyl aldehyde dehydrogenase 2 co-expressed in Escherichia coli cells In aq. phosphate buffer at 30℃; for 12h; pH=7; Reagent/catalyst; Microbiological reaction;	99%

: 98-00-0
(2-furyl)methyl alcohol

: 88-14-2
2-furanoic acid

Conditions

Conditions	Yield
With manganese(IV) oxide; oxygen; sodium hydrogencarbonate In water at 100℃; under 7500.75 Torr; for 24h;	99%
With oxygen; 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazolium chloride; sodium t-butanolate In dichloromethane at 20℃; for 30h; Reagent/catalyst; Molecular sieve;	95%
With sodium carbonate In water at 30℃; for 40h; Wavelength; Irradiation;	93%

: 74117-32-1
Furan-2-yl-indol-1-yl-methanone

: 88-14-2
2-furanoic acid

Conditions

Conditions	Yield
With lithium hydroxide; dihydrogen peroxide In tetrahydrofuran; water for 2.5h; Product distribution; other reag.; other solvent;	99%

: 5380-40-5
furan-2-carboxylic acid benzyl ester

: 108-88-3
toluene

A: 88-14-2
2-furanoic acid

B: 620-47-3
1-methyl-3-(phenylmethyl)-benzene

C: 620-83-7
1-methyl-4-(phenylmethyl)benzene

D: 713-36-0
2-benzyltoluene

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate; water at 80℃; for 2h; regioselective reaction;	A 99% B n/a C n/a D n/a

...Expand

: 2-(azulen-6-yl)ethyl 2-furoate

: 88-14-2
2-furanoic acid

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃; for 4h;	97%

: 552-86-3
furoin

: 88-14-2
2-furanoic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; methyltrioxorhenium(VII); magnesium sulfate In acetonitrile for 1.5h; Heating;	96%
With sodium hypochlorite for 0.25h; Irradiation;	83%
With sodium carbonate In acetone for 1h; Irradiation;	69%
With graphitic carbon nitride; oxygen; acetic acid In water; acetonitrile at 100℃; under 2250.23 Torr; for 16h; Autoclave; Irradiation; Green chemistry;	55 %Chromat.

: 326-90-9
4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione

: 88-14-2
2-furanoic acid

Conditions

Conditions	Yield
With oxygen; sodium hydrogencarbonate In acetonitrile for 4h; Molecular sieve; Irradiation;	96%

: 1192-62-7
1-(2-furyl)-1-ethanone

: 88-14-2
2-furanoic acid

Conditions

Conditions	Yield
With iodine; sodium hydroxide In water at 30℃; pH=7; Reagent/catalyst; Temperature;	95%
With hydroxylamine hydrochloride; iodine In dimethyl sulfoxide at 100℃; for 5h;	80%
With Oxone; trifluoroacetic acid In 1,4-dioxane for 10h; Reflux; Green chemistry;	67%

: C9H10O2S2

: 88-14-2
2-furanoic acid

Conditions

Conditions	Yield
With sodium hydroxide In water at 100℃; for 9h; Reflux; chemoselective reaction;	95%

: 2-(furan-2-yl)-5,5-dimethyl-[1,3,2]dioxaborinane

: 124-38-9
carbon dioxide

: 88-14-2
2-furanoic acid

Conditions

Conditions	Yield
Stage #1: 2-(furan-2-yl)-5,5-dimethyl-[1,3,2]dioxaborinane; carbon dioxide With [Ni(N,N'-bis[2,6-bis(diphenylmethyl)-4-methylphenyl]imidazole-2-ylidene)(allyl)Cl]; potassium tert-butylate In toluene at 100℃; under 760.051 Torr; for 15h; Schlenk technique; Inert atmosphere; Stage #2: With hydrogenchloride In water; ethyl acetate; toluene at 20℃;	93%
Stage #1: 2-(furan-2-yl)-5,5-dimethyl-[1,3,2]dioxaborinane; carbon dioxide With potassium tert-butylate; silver(I) acetate; triphenylphosphine In tetrahydrofuran at 70℃; under 15201 Torr; for 16h; Inert atmosphere; Autoclave; Stage #2: With hydrogenchloride In tetrahydrofuran; water Inert atmosphere;	83%
With potassium tert-butylate; copper(l) chloride; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride In tetrahydrofuran at 70℃; under 760.051 Torr; for 24h;	73%

: 614-99-3
Ethyl 2-furoate

: 88-14-2
2-furanoic acid

Conditions

Conditions	Yield
With methanol; potassium hydroxide at 35℃;	91%
Stage #1: Ethyl 2-furoate With iron(III) chloride In 1,1,2,2-tetrachloroethane at 115℃; for 24h; Inert atmosphere; Stage #2: With hydrogenchloride; water In 1,1,2,2-tetrachloroethane Inert atmosphere;	54%
With alkaline H2O In dimethyl sulfoxide at 30℃; Rate constant; other solvent (EtOH); variation of water concentrations;
Stage #1: Ethyl 2-furoate With sodium hydroxide In water at 20℃; Stage #2: With hydrogenchloride In water

: 584-12-3
2-bromofuran

: 590-29-4
potassium formate

: 88-14-2
2-furanoic acid

Conditions

Conditions	Yield
With [PhCOPd(PtBu3)I]; dtbpf In 2-methyltetrahydrofuran at 80℃; for 18h; Inert atmosphere;	91%

: 617-90-3
2-furancarbonitrile

: 88-14-2
2-furanoic acid

Conditions

Conditions	Yield
With benzene-1,2-dicarboxylic acid for 0.75h; microwave-irradiation;	90%
With phosphate buffer at 30℃; for 72h; rhodococcus rhodocrous AJ270, pH 7.0;	83%
With potassium phosphate buffer at 30℃; for 7h; Rhodococcus sp. AJ270 cells;	83.1%

: 17090-71-0
furan-2-yl-oxo-acetaldehyde

: 88-14-2
2-furanoic acid

Conditions

Conditions	Yield
With iodine; dimethyl sulfoxide at 180℃; for 0.0833333h; Inert atmosphere; Microwave irradiation;	89%
With tert.-butylhydroperoxide for 13h;	74%

: 98-01-1
furfural

A: 88-14-2
2-furanoic acid

B: 110-16-7
maleic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; 5 weight percent methyltrioxorhenium on polystyrene In water at 20℃; Product distribution / selectivity;	A 87% B 1%
With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide In water; acetonitrile at 10℃; for 1h;	A 82% B 15%
With dihydrogen peroxide; 5 weight percent methyltrioxorhenium on polystyrene In water at 20℃; for 24h; Product distribution / selectivity;	A 18% B 82%
With water; dihydrogen peroxide at 60℃; for 4h; pH=7.5;	A 45 %Spectr. B n/a

: 5380-40-5
furan-2-carboxylic acid benzyl ester

: 88-14-2
2-furanoic acid

Conditions

Conditions	Yield
With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate at 20℃; for 0.166667h; chemoselective reaction;	86%

: 609-38-1
furan-2-carboxylic acid amide

: 88-14-2
2-furanoic acid

Conditions

Conditions	Yield
With niobium(V) oxide; water In neat (no solvent) for 20h; Reflux; Inert atmosphere;	85%

: 617-90-3
2-furancarbonitrile

A: 88-14-2
2-furanoic acid

B: 609-38-1
furan-2-carboxylic acid amide

Conditions

Conditions	Yield
With phosphate buffer at 30℃; for 1h; rhodococcus rhodocrous AJ270, pH 7.0;	A 12.5% B 82%
With potassium phosphate buffer at 30℃; for 1h; Rhodococcus sp. AJ270 cells;	A 12.5% B 82.2%

: 98-01-1
furfural

A: 88-14-2
2-furanoic acid

B: 110-15-6
succinic acid

C: 110-16-7
maleic acid

Conditions

Conditions	Yield
With tetrafluoroboric acid; dihydrogen peroxide; 5 weight percent methyltrioxorhenium on polystyrene In water at 20℃; for 24h; Product distribution / selectivity;	A 9% B 10% C 81%
With dihydrogen peroxide; acetic acid; 5 weight percent methyltrioxorhenium on poly(4-vinylpyridine) In water at 20℃;	A 41% B 6% C 40%
With water; dihydrogen peroxide at 60℃; for 4h; pH=6; pH-value;	A 50 %Spectr. B n/a C n/a

...Expand

: 98-00-0
(2-furyl)methyl alcohol

A: 98-01-1
furfural

B: 88-14-2
2-furanoic acid

Conditions

Conditions	Yield
With potassium carbonate In Petroleum ether Ambient temperature; electrolysis (Beaker type circulation cell): nickel anode, steel cathode, 0.2 A, current consumption 4.2 F/mol;	A 78% B 11 % Chromat.
With sodium hydroxide; oxygen In toluene at 70℃; for 2h; or KOH; Yields of byproduct given. Title compound not separated from byproducts;	A n/a B 35%
With potassium carbonate In Petroleum ether Ambient temperature; electrolysis (Beaker type circulation cell): nickel anode, steel cathode, 0.2 A, current consumption 4.2 F/mol;	A 78 % Chromat. B 11%

: 504-29-0
2-aminopyridine

: 492-94-4
furil

A: 88-14-2
2-furanoic acid

B: 35218-40-7
N-(pyridin-2-yl)furan-2-carboxamide

Conditions

Conditions	Yield
With oxygen; copper dichloride; Trimethylacetic acid In m-xylene; tert-butyl alcohol at 80 - 85℃; for 48h;	A 5% B 76%

...Expand

: 623-15-4
4-(furan-2-yl)but-3-en-2-one

: 88-14-2
2-furanoic acid

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; iodine In dimethyl sulfoxide at 100℃; for 6h;	75%

: 584-12-3
2-bromofuran

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

A: 88-14-2
2-furanoic acid

B: 611-13-2
2-furoic acid methyl ester

Conditions

Conditions	Yield
With tert-Amyl alcohol; sodium hydride; cobalt(II) acetate In tetrahydrofuran at 40℃; under 760 Torr; for 42h; Irradiation;	A 2% B 72%

...Expand

: 584-12-3
2-bromofuran

: 201230-82-2
carbon monoxide

A: 88-14-2
2-furanoic acid

B: 611-13-2
2-furoic acid methyl ester

Conditions

Conditions	Yield
With methanol; tert-Amyl alcohol; sodium hydride; cobalt(II) acetate In tetrahydrofuran at 40℃; under 760 Torr; for 42h; Irradiation;	A 2% B 72%

...Expand

: 492-94-4
furil

: 88-14-2
2-furanoic acid

Conditions

Conditions	Yield
With sodium hypochlorite for 0.666667h; Irradiation;	71%
With tetraethylammonium bromide; potassium oxide In N,N-dimethyl-formamide at 30℃; for 3.5h;	65%

: 110-00-9
furan

: 124-38-9
carbon dioxide

: 88-14-2
2-furanoic acid

Conditions

Conditions	Yield
With 2,6-Dibromopyridine; ethylaluminum dichloride In hexane; toluene at 60℃; under 22502.3 Torr; for 3h; Autoclave; Inert atmosphere;	71%
Stage #1: furan With n-butyllithium In tetrahydrofuran; hexane at -30℃; Stage #2: carbon dioxide In tetrahydrofuran; hexane under 975.098 Torr; Stage #3: With hydrogenchloride In tetrahydrofuran; hexane; water at 0℃;	> 80 %Chromat.

: 88-14-2
2-furanoic acid

: 16874-33-2
tetrahydro-2-furancarboxylic acid

Conditions

Conditions	Yield
With (S)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyldicyclohexylphosphine; hydrogen; di(norbornadiene)rhodium(I) tetrafluoroborate In methanol at 60℃; under 75006 Torr; for 19h; Product distribution; Further Variations:; Reagents;	100%
With hydrogen; palladium on activated charcoal In ethyl acetate	95%
With water; palladium Hydrogenation;

: 88-14-2
2-furanoic acid

: 14032-66-7
5-hydroxy-2-(5H)-furanone

Conditions

Conditions	Yield
With oxygen; rose bengal In methanol at 25℃; for 4h; Irradiation;	100%
With oxygen; fullerene-C60; [5,6]fullerene-C70 In methanol; toluene for 3.5h; Ambient temperature; Irradiation;	100%
With rose bengal In methanol at 25℃; for 3h; Irradiation;	100%

: 88-14-2
2-furanoic acid

: 617-89-0
furan-2-ylmethanamine

: 61190-74-7
N-(furan-2-ylmethyl)furan-2-carboxamide

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 25℃;	100%
With 4-methyl-morpholine; 4‐(4,6‐dimethoxy‐1,3,5‐triazin‐2‐yl)‐4‐methylmorpholinium toluene‐4‐sulfonate In dichloromethane at 90℃; for 0.166667h; Reagent/catalyst; Solvent; Microwave irradiation;	84%

: 88-14-2
2-furanoic acid

: 1792-81-0
cis-1,2-cyclohexane

: cis-1,2-cyclohexane-1,2-diyl di(2-furoate)

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃;	100%

: 88-14-2
2-furanoic acid

: 14690-00-7
2-O-benzylglycerol

: 2-(benzyloxy)propane-1,3-diyl di(2-furoate)

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃;	100%

: 88-14-2
2-furanoic acid

: 513-86-0, 52217-02-4
3-hydroxy-2-butanon

: 3-oxobutan-2-yl furan-2-carboxylate

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 5h;	100%

: 88-14-2
2-furanoic acid

: 1619984-56-3
C21H33N3O

: 1619983-85-5
N-((2R,3S,4S,4aS)-4-((furan-2-carboxamido)methyl)-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl)nicotinamide

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 18h; Inert atmosphere;	100%

: 88-14-2
2-furanoic acid

: 83768-75-6
2-hydroxy-1-(2-hydroxy-4,6-dimethoxyphenyl)ethan-1-one

: 2-(2-((furan-2-carbonyl)oxy)-4,6-dimethoxyphenyl)-2-oxoethyl furan-2-carboxylate

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane Reflux;	100%

: 88-14-2
2-furanoic acid

: 4077-58-1
2-(iodomethyl)-5-nitrofuran

: 25294-74-0
Furan-2-carboxylic acid 5-nitro-furan-2-ylmethyl ester

Conditions

Conditions	Yield
With IRA 904 In acetonitrile 2.) 25 deg C, 20 h;	99%

: 88-14-2
2-furanoic acid

: 4525-33-1
dimethyl dicarbonate

: 611-13-2
2-furoic acid methyl ester

Conditions

Conditions	Yield
magnesium(II) perchlorate In nitromethane at 40℃; for 16h;	99%
With dmap In tetrahydrofuran for 88h;	97%

: 88-14-2
2-furanoic acid

: 685089-20-7
1-acetyl-3,3-bis(hydroxymethyl)oxindole

: 685089-26-3
1-acetyl-3,3-bis(2-furoyloxymethyl)oxindole

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 20℃; for 7h;	99%

: 88-14-2
2-furanoic acid

: 685089-19-4
1-(benzyloxycarbonyl)-3,3-bis(hydroxymethyl)oxindole

: 685089-25-2
1-(benzyloxycarbonyl)-3,3-bis(2-furoyloxymethyl)oxindole

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 20℃;	99%

: 743477-27-2
2-hydroxy-1,1,2-trimethylpropyl ethylcarbamate

: 88-14-2
2-furanoic acid

A: 19424-29-4
4,4,5,5-tetramethyl-1,3-dioxolan-2-one

B: 614-99-3
Ethyl 2-furoate

Conditions

Conditions	Yield
With tert.-butylnitrite; 3 A molecular sieve In dichloromethane at 60℃; for 12h;	A n/a B 99%

...Expand

: 88-14-2
2-furanoic acid

: 603-36-1
triphenylantimony

: 126117-45-1
triphenylantimony bis(2-furoinate)

Conditions

Conditions	Yield
With H2O2 In diethyl ether; water 42% aq. soln. of hydrogen peroxide added to reagent mixt. at 20°C, stored for 12 h; solvent evapd., recrystd. (toluene), elem. anal.;	99%

: 88-14-2
2-furanoic acid

: (-)-englerin B

: C29H34O6

Conditions

Conditions	Yield
With dmap; 2,4,6-trichlorobenzoyl chloride; triethylamine In toluene at 20℃; Yamaguchi esterification; Inert atmosphere;	99%

: 88-14-2
2-furanoic acid

: AuOH(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)

: [N,N-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](furan-2-yl)gold(I)

Conditions

Conditions	Yield
In toluene byproducts: CO2, H2O; N2 or air, 1:1 mixt. refluxed at 110°C for 0.5 h; dried (vac.);	99%

: 88-14-2
2-furanoic acid

: 1117-97-1
N,0-dimethylhydroxylamine

: 95091-92-2
N-methoxy-N-methyl-2-furancarboxamide

Conditions

Conditions	Yield
Stage #1: 2-furanoic acid; N,0-dimethylhydroxylamine In toluene at 0℃; for 0.166667h; Stage #2: With phosphorus trichloride In toluene at 20 - 60℃; for 0.5h;	99%

: 88-14-2
2-furanoic acid

: 108-23-6
isopropyl chloroformate

: C9H10O5

Conditions

Conditions	Yield
Stage #1: 2-furanoic acid With trimethylamine In tetrahydrofuran at 20℃; for 0.166667h; Inert atmosphere; Sealed tube; Stage #2: isopropyl chloroformate With triethylamine In tetrahydrofuran; toluene at 0 - 20℃; for 1.66667h; Inert atmosphere; Sealed tube;	99%

: 88-14-2
2-furanoic acid

: 156-87-6
propan-1-ol-3-amine

: 3-hydroxypropyl furan-2-carboxylate

Conditions

Conditions	Yield
With propane-1,3-diyl dinitrite In tert-butyl alcohol at 80℃; for 16h; Solvent;	99%

: 88-14-2
2-furanoic acid

: 3-benzyl-4-(4-hydroxy-2-methoxytetrahydro-2H-pyran-2-yl)thiazolidin-2-one

: 2-((R)-3-benzyl-2-oxothiazolidin-4-yl)-2-methoxytetrahydro-2H-pyran-4-yl furan-2-carboxylate

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;	99%

: 88-14-2
2-furanoic acid

: 124-38-9
carbon dioxide

: 3238-40-2
furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With Pd/G In 1,2-dimethoxyethane at 70℃; under 7500.75 Torr; for 10h; Reagent/catalyst; Temperature; Pressure; Autoclave; Sealed tube; Green chemistry;	98%
With Pd/4A molecular sieve catalyst In 1,2-dimethoxyethane at 70 - 100℃; under 75.0075 Torr; for 1.66667h; Solvent; Reagent/catalyst; Temperature; Pressure; Molecular sieve; Large scale;	98.8%
Stage #1: 2-furanoic acid With potassium carbonate; caesium carbonate In water Green chemistry; Stage #2: carbon dioxide at 260 - 285℃; under 6000.6 Torr; for 24h; Flow reactor; Green chemistry; Stage #3: With hydrogenchloride In water pH=2; Reagent/catalyst; Pressure; Temperature; Green chemistry;	89%

: 88-14-2
2-furanoic acid

: 4-isopropyl-1-methylcyclohex-3-en-1-amine

: N-(4-isopropyl-1-methylcyclohex-3-en-1-yl)furan-2-carboxamide

Conditions

Conditions	Yield
Stage #1: 2-furanoic acid With thionyl chloride; N,N-dimethyl-formamide In dichloromethane Reflux; Stage #2: 4-isopropyl-1-methylcyclohex-3-en-1-amine With triethylamine In dichloromethane; N,N-dimethyl-formamide Reflux;	98.53%

: 67-56-1
methanol

: 88-14-2
2-furanoic acid

: 611-13-2
2-furoic acid methyl ester

Conditions

Conditions	Yield
With phosphotungstic acid for 4h; Reflux;	98%
With sulfuric acid for 4h; Reflux;	93%
With potassium carbonate In ethyl acetate for 1.5h; Heating;	92%

2-Furoic acid Consensus Reports

A poison by intraperitoneal route. Reported in EPA TSCA Inventory.

2-Furoic acid Specification

The 2-Furoic acid, with the CAS registry number 88-14-2, is also known as Acide 2-furanecarboxylique. It belongs to the product categories of Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts; Furan & Benzofuran; Organic Acids; Furans. Its EINECS registry number is 208-422-9. This chemical's molecular formula is C₅H₄O₃ and molecular weight is 112.08. What's more, its IUPAC name is called Furan-2-carboxylic acid. It should be stored in a cool, dry and well-ventilated place.

Physical properties about 2-Furoic acid are: (1)ACD/LogP: 0.636; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.64; (4)ACD/LogD (pH 7.4): -2.48; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 3; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 50.44 Å²; (13)Index of Refraction: 1.513; (14)Molar Refractivity: 25.483 cm³; (15)Molar Volume: 84.758 cm³; (16)Polarizability: 10.102×10^-24cm³; (17)Surface Tension: 48.248 dyne/cm; (18)Density: 1.322 g/cm³; (19)Flash Point: 94.195 °C; (20)Enthalpy of Vaporization: 49.548 kJ/mol; (21)Boiling Point: 232.14 °C at 760 mmHg; (22)Vapour Pressure: 0.033 mmHg at 25 °C.

Preparation of 2-Furoic acid: this chemical can be prepared by furfural. This reaction needs reagent pyridinium chlorochromate at temperature of 20 °C. The reaction time is 6 hours. The yield is 82 %.

2-Furoic acid can be prepared by furfural.

Uses of 2-Furoic acid: (1) it is used as plasticizer, preservative and fungicide; (2) it is used to produce other chemicals. For example, it can react with methanol to get furan-2-carboxylic acid methyl ester. The reaction occurs with reagent H₂SO₄ and other condition of heating for 10 hours. The yield is 80 %.

2-Furoic acid can react with methanol to get furan-2-carboxylic acid methyl ester.

When you are dealing with this chemical, you should be very careful. This chemical is inflammation to the skin or other mucous membranes and may destroy living tissue on contacting. What's more, it may cause burns. Therefore, you should wear suitable protective clothing, gloves and eye/face protection. And you must take off immediately all contaminated clothing. In case of contacting with eyes or skin, you should rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1) SMILES: OC(=O)c1ccco1
(2) InChI: InChI=1S/C5H4O3/c6-5(7)4-2-1-3-8-4/h1-3H,(H,6,7)
(3) InChIKey: SMNDYUVBFMFKNZ-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	100mg/kg (100mg/kg)		Pharmaceutical Research. Vol. 2, Pg. 233, 1985.

Product Name

2-Furoic acid

Synthetic route

2-Furoic acid Consensus Reports

2-Furoic acid Specification

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