• Name

  2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid

• EINECS 223-772-2
• CAS No. 4065-45-6
• Article Data14
• CAS DataBase
• Density 1.449 g/cm³
• Solubility 300.92g/L at 25℃
• Melting Point 170 °C
• Formula C₁₄H₁₂O₆S
• Boiling Point 0°C
• Molecular Weight 308.312
• Flash Point 0°C
• Transport Information
• Appearance white to yellowish powder
• Safety 26-36-37/39-36/37/39-27
• Risk Codes 36/37/38
• Molecular Structure
• Hazard Symbols Xi
• Synonyms 1-Phenol-4-sulfonicacid, 2-benzoyl-5-methoxy- (6CI);2-Hydroxy-4-methoxy-5-sulfobenzophenone;2-Methoxy-4-hydroxy-5-benzoylbenzenesulfonic acid;3-Benzoyl-4-hydroxy-6-methoxybenzenesulfonic acid;5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid;Benzophenone 4;Escalol 577;MS 40;NSC 60584;Seesorb 101S;Spectra-Sorb UV 284;Sulisobenzone;
• PSA 109.28000
• LogP 2.95930

Synthetic route

131-57-7

Benzophenone-3

4065-45-6

2-hydroxy-4-methoxybenzophenone-5-sulfonic acid

Conditions

Conditions	Yield
With sulfur trioxide; acetic acid In 1,2-dichloro-ethane at 25℃; for 3h; Inert atmosphere;	98.82%
With chlorosulfonic acid In ethyl acetate at 45℃; Temperature;	96%
With chlorosulfonic acid In phthalic acid dimethyl ester
With chlorosulfonic acid at 25℃; for 20h; Inert atmosphere; Autoclave;

4-benzoyloxy-2-methoxybenzenesulfonic acid

4065-45-6

2-hydroxy-4-methoxybenzophenone-5-sulfonic acid

Conditions

Conditions	Yield
In methanol at 35℃; for 0.333333h; UVB irradiation;

4065-45-6

2-hydroxy-4-methoxybenzophenone-5-sulfonic acid

108-90-7

chlorobenzene

817203-48-8

C14H11O6S(1-)*C18H12Cl3S(1+)

Conditions

Conditions	Yield
Stage #1: chlorobenzene With thionyl chloride; aluminum (III) chloride at 20 - 150℃; for 5h; Stage #2: With water at 60℃; for 1h; Stage #3: 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid In water for 4h;	79%

4065-45-6

2-hydroxy-4-methoxybenzophenone-5-sulfonic acid

158547-83-2

3,5-dichloro-2-hydroxy-4-methoxybenzophenone

Conditions

Conditions	Yield
With trichloroisocyanuric acid; sodium hydrogencarbonate In water	33%

4065-45-6

2-hydroxy-4-methoxybenzophenone-5-sulfonic acid

1631050-95-7

5-benzoyl-3-chloro-4-hydroxy-2-methoxybenzenesulfonic acid

Conditions

Conditions	Yield
With hydrogenchloride; sodium hypochlorite In water for 2h; Cooling with ice;	18%

4065-45-6

2-hydroxy-4-methoxybenzophenone-5-sulfonic acid

1609-47-8

diethyl dicarbonate

19337-04-3

2--4-methoxy-5-sulfo-benzophenon

4065-45-6

2-hydroxy-4-methoxybenzophenone-5-sulfonic acid

77-78-1

dimethyl sulfate

sodium 2,4-dimethoxy-5-benzoylbenzenesulfonate

Conditions

Conditions	Yield
With sodium hydroxide Heating;

4065-45-6

2-hydroxy-4-methoxybenzophenone-5-sulfonic acid

121715-18-2

5-benzoyl-4-hydroxy-2-methoxy-benzenesulfonyl chloride

2-[2-[2-chloro-3-[(1,3-dihydro-1,3,3-trimethyl-2H-indol-2-ylidene)ethylidene]-1-cyclohexen-1-yl]ethenyl]-1,3,3-trimethyl-3H-indolium bromide

4065-45-6

2-hydroxy-4-methoxybenzophenone-5-sulfonic acid

2-[2-[2-chloro-3-[(1,3-dihydro-1,3,3-trimethyl-2H-indol-2-ylidene)ethylidene]-1-cyclohexen-1-yl]ethenyl]-1,3,3-trimethyl-3H-indolium, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid salt

Conditions

Conditions	Yield
Stage #1: 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid With sodium hydrogencarbonate In 1-methoxy-2-propanol; water Stage #2: 2-[2-[2-chloro-3-[(1,3-dihydro-1,3,3-trimethyl-2H-indol-2-ylidene)ethylidene]-1-cyclohexen-1-yl]ethenyl]-1,3,3-trimethyl-3H-indolium bromide In 1-methoxy-2-propanol; water at 20℃; for 2.16667h; In the dark;

4065-45-6

2-hydroxy-4-methoxybenzophenone-5-sulfonic acid

99-09-2

3-nitro-aniline

1243203-31-7

1-[2-hydroxy-4-methoxy-5-(3-nitrophenylazo)phenyl]-1-phenylmethanone

Conditions

Conditions	Yield
Stage #1: 3-nitro-aniline With hydrogenchloride In water at 70℃; for 0.5h; Stage #2: With sodium nitrite In water at 0 - 5℃; Stage #3: 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid regioselective reaction; Further stages;	10.73 %Chromat.

4065-45-6

2-hydroxy-4-methoxybenzophenone-5-sulfonic acid

88-74-4

2-nitro-aniline

1243203-29-3

1-[2-hydroxy-4-methoxy-5-(2-nitrophenylazo)phenyl]-1-phenylmethanone

Conditions

Conditions	Yield
Stage #1: 2-nitro-aniline With hydrogenchloride In water at 70℃; for 0.5h; Stage #2: With sodium nitrite In water at 0 - 5℃; Stage #3: 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid regioselective reaction; Further stages;	5.14 %Chromat.

4065-45-6

2-hydroxy-4-methoxybenzophenone-5-sulfonic acid

97-02-9

2,4-Dinitroanilin

1446786-84-0

C20H14N4O7

Conditions

Conditions	Yield
Stage #1: 2,4-Dinitroanilin With sulfuric acid; sodium nitrite at 0 - 70℃; Stage #2: 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid With sodium carbonate In ethanol at -20℃; for 2.5h; pH=8 - 9; Stage #3: With hydrogenchloride In ethanol; water pH=3; regioselective reaction;	9.9 %Chromat.

455-14-1

4-trifluoromethylphenylamine

4065-45-6

2-hydroxy-4-methoxybenzophenone-5-sulfonic acid

1446786-85-1

C21H15F3N2O3

Conditions

Conditions	Yield
Stage #1: 4-trifluoromethylphenylamine With hydrogenchloride; sodium nitrite In water at 0 - 5℃; Stage #2: 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid With sodium carbonate In ethanol; water at -20℃; for 2.5h; pH=8 - 9; Stage #3: With hydrogenchloride In ethanol; water pH=3; regioselective reaction;	13.2 %Chromat.

4065-45-6

2-hydroxy-4-methoxybenzophenone-5-sulfonic acid

100-01-6

4-nitro-aniline

1243203-30-6

1-[2-hydroxy-4-methoxy-5-(4-nitrophenylazo)phenyl]-1-phenylmethanone

Conditions

Conditions	Yield
Stage #1: 4-nitro-aniline With hydrogenchloride In water at 70℃; for 0.5h; Stage #2: With sodium nitrite In water at 0 - 5℃; Stage #3: 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid Temperature; Solvent; regioselective reaction; Further stages;	43.94 %Chromat.

4065-45-6

2-hydroxy-4-methoxybenzophenone-5-sulfonic acid

C14H11O6S

Conditions

Conditions	Yield
In water; acetonitrile Photolysis; Inert atmosphere;

4065-45-6

2-hydroxy-4-methoxybenzophenone-5-sulfonic acid

131-57-7

Benzophenone-3

Conditions

Conditions	Yield
With sulfuric acid; water at 110℃; for 5h; Temperature; Reagent/catalyst;	85.95 g

magnesium(II) nitrate hexahydrate

zinc(II) nitrate hexahydrate

aluminum nitrate hexahydrate

140-10-3

(E)-3-phenylacrylic acid

4065-45-6

2-hydroxy-4-methoxybenzophenone-5-sulfonic acid

7732-18-5

water

1310-73-2

sodium hydroxide

Mg0.499Zn0.221Al0.280(OH)2(cinnamate)0.140(2-hydroxy-4-methoxybenzophenone-5-sulphonate)0.140*1.06H2O

Conditions

Conditions	Yield
Stage #1: (E)-3-phenylacrylic acid; 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid; water; sodium hydroxide at 80℃; Inert atmosphere; Stage #2: magnesium(II) nitrate hexahydrate; zinc(II) nitrate hexahydrate; aluminum nitrate hexahydrate; water at 20℃; for 0.666667h; Inert atmosphere; Stage #3: (E)-3-phenylacrylic acid With sodium hydroxide at 95℃; for 12h; pH=Ca. 6.62; Inert atmosphere;

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magnesium(II) nitrate hexahydrate

zinc(II) nitrate hexahydrate

aluminum nitrate hexahydrate

4065-45-6

2-hydroxy-4-methoxybenzophenone-5-sulfonic acid

7732-18-5

water

1310-73-2

sodium hydroxide

Mg0.465Zn0.245Al0.291(OH)2(2-hydroxy-4-methoxybenzophenone-5-sulphonate)0.291*1.28H2O

Conditions

Conditions	Yield
Stage #1: 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid; water; sodium hydroxide at 80℃; Inert atmosphere; Stage #2: magnesium(II) nitrate hexahydrate; zinc(II) nitrate hexahydrate; aluminum nitrate hexahydrate; water at 20℃; for 0.666667h; Inert atmosphere; Stage #3: With sodium hydroxide at 95℃; for 12h; pH=Ca. 6.62; Inert atmosphere;

...Expand

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Chemical Properties

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Uses

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Toxicity Data With Reference

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Safety Profile

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Specification