2-Methoxyethanol supplier | CasNO.109-86-4

Name
2-Methoxyethanol
EINECS 203-713-7
CAS No. 109-86-4
Article Data154
CAS DataBase
Density 0.958 g/cm³
Solubility soluble in water
Melting Point -85 °C
Formula C₃H₈O₂
Boiling Point 124.4 °C at 760 mmHg
Molecular Weight 76.0953
Flash Point 46.1 °C
Transport Information UN 1188 3/PG 3
Appearance clear colorless liquid
Safety 53-45-36/37-16-26-23
Risk Codes 60-61-10-20/21/22-39/23/24/25-23/24/25-11-35
Molecular Structure
Hazard Symbols T,F,C
Synonyms 1-Hydroxy-2-methoxyethane;2-Methoxy-1-ethanol;2-Methoxyethyl alcohol;2-Methyloxyethanol;3-Oxa-1-butanol;Amsco-Solv EE;Dowanol EM;Ektasolve EM;Ethylene glycol methyl ether;Ethylene glycol monomethyl ether;Methyl Cellosolve;Methyl glycol;Methyl oxitol;Monoethylene glycol methyl ether;Monomethylglycol;NSC 1258;Poly-Solv EM;b-Methoxyethanol;
PSA 29.46000
LogP -0.37490

Synthetic route

: 1245613-17-5
4-benzyloxycarbonylaminobutyric acid 2-methoxyethyl ester

A: 109-86-4
2-methoxy-ethanol

B: 5105-78-2
4-(benzyloxycarbonylamino)butyric acid

Conditions

Conditions	Yield
With methanol; Bacillus subtilis esterase In hexane at 37℃; for 0.5h; pH=7.4; Kinetics; Reagent/catalyst; Time; aq. phosphate buffer; Enzymatic reaction;	A n/a B 100%

: 6290-49-9
methyl methoxyacetate

: 109-86-4
2-methoxy-ethanol

Conditions

Conditions	Yield
With trans-RuCl2(PPh3)[PyCH2NH(CH2)2PPh2]; potassium tert-butylate; hydrogen In tetrahydrofuran at 40℃; under 37503.8 Torr; for 16h;	100%
With hydrogen; sodium methylate; [carbonylchlorohydrido{bis[2-(diphenylphosphinomethyl)ethyl]amino}ethylamino] ruthenium(II) In methanol at 80℃; under 37503.8 Torr; for 8h;
With ruthenium(bis[2‐(ethylsulfanyl)ethyl]amine)(dichloro)(triphenylphosphine); potassium methanolate; hydrogen In tetrahydrofuran at 60℃; under 37503.8 Torr; for 16h; Glovebox; Inert atmosphere;
With C24H38Cl2N3PRu; hydrogen; sodium methylate In isopropyl alcohol at 25℃; under 38002.6 Torr; for 4h; Autoclave;	99 %Chromat.
With C24H38Cl2N3PRu; hydrogen; sodium methylate In isopropyl alcohol at 25℃; under 37503.8 Torr; for 4h;	99 %Spectr.

: 75-21-8
oxirane

: 67-56-1
methanol

: 109-86-4
2-methoxy-ethanol

Conditions

Conditions	Yield
With bentonite clay at 50℃; for 18h; Product distribution; other oxides and reactions partners; var. temperatures and amounts of reaction partners;	98.1%
With sulfuric acid
With boron trifluoride diethyl etherate at -10℃;

: 4819-82-3
2-(2-methoxy-ethoxy)-tetrahydro-pyran

: 109-86-4
2-methoxy-ethanol

Conditions

Conditions	Yield
With methanol at 20℃; for 0.5h;	97%

: 100-51-6
benzyl alcohol

: 74-88-4
methyl iodide

: 109-86-4
2-methoxy-ethanol

Conditions

Conditions	Yield
With iron(III) perchlorate at 20℃; for 1.5h; neat (no solvent);	88%

: 75-21-8
oxirane

: 143-24-8
Tetraethylene glycol dimethyl ether

: 201230-82-2
carbon monoxide

A: 109-86-4
2-methoxy-ethanol

B: 6149-41-3
methyl ester (3-hydroxy) propionic acid

C: 27313-49-1
methyl β-(β-hydroxypropionyloxy)propionate

D: 75-07-0
acetaldehyde

Conditions

Conditions	Yield
3-HYDROXYPYRIDINE; dicobalt octacarbonyl at 75℃; under 45004.5 Torr; for 4h; Heating / reflux;	A n/a B 81.08% C n/a D n/a

...Expand

: 625-45-6
2-methoxyacetic acid

: 109-86-4
2-methoxy-ethanol

Conditions

Conditions	Yield
With ruthenium-carbon composite; hydrogen In water at 119.84℃; under 7500.75 - 60006 Torr; for 2h; Catalytic behavior; Autoclave; Sealed tube;	81%

: 41017-81-6
2-methoxyethyl trifluoroacetate

A: 109-86-4
2-methoxy-ethanol

B: 75-89-8
2,2,2-trifluoroethanol

Conditions

Conditions	Yield
With trans-[(2,6-bis(di-tert-butylphosphinomethyl)pyridine)Fe(H)2(CO)]; hydrogen; sodium methylate In 1,4-dioxane at 40℃; under 18751.9 Torr; for 16h; Glovebox; Inert atmosphere;	A n/a B 80%

: 67-56-1
methanol

: 107-07-3
2-chloro-ethanol

: 109-86-4
2-methoxy-ethanol

Conditions

Conditions	Yield
With sodium ethanolate at 78℃; for 1h;	78%

: 31600-56-3
[(2-methoxyethoxy)methyl] benzene

A: 109-86-4
2-methoxy-ethanol

B: 65-85-0
benzoic acid

Conditions

Conditions	Yield
With bis(acetylacetonate)oxovanadium; methyl 3,5-bis((1H-1,2,4-triazol-1-yl)methyl)benzoate; oxygen; sodium acetate at 120℃; for 48h;	A 76% B 78%

: 111-77-3
2-(2-methoxyethoxy)ethyl alcohol

A: 110-71-4
1,2-dimethoxyethane

B: 112-49-2
Triethylene glycol dimethyl ether

C: 109-86-4
2-methoxy-ethanol

D: 111-96-6
diethylene glycol dimethyl ether

Conditions

Conditions	Yield
5%-palladium/activated carbon; nickel at 220℃; under 2250.23 Torr; for 10h;	A 75% B 2% C 10% D 11%

...Expand

: 625-45-6
2-methoxyacetic acid

A: 67-56-1
methanol

B: 109-86-4
2-methoxy-ethanol

Conditions

Conditions	Yield
With hydrogen In water at 119.84℃; under 7500.75 - 60006 Torr; for 2h; Catalytic behavior; Reagent/catalyst; Autoclave; Sealed tube;	A 12% B 74%

: 1-Methoxy-4-(2-methoxy-ethoxymethyl)-benzene

A: 109-86-4
2-methoxy-ethanol

B: 83318-92-7
ethyl p-methoxybenzyl sulfide

Conditions

Conditions	Yield
With aluminium trichloride; ethanethiol In dichloromethane for 3h; Ambient temperature;	A 73% B n/a

: 96-49-1
[1,3]-dioxolan-2-one

: 67-56-1
methanol

A: 109-86-4
2-methoxy-ethanol

B: 107-21-1
ethylene glycol

C: 616-38-6
carbonic acid dimethyl ester

D: 111-46-6
diethylene glycol

Conditions

Conditions	Yield
at 76.7 - 79.6℃; under 757.576 Torr; Product distribution / selectivity; Industry scale;	A n/a B 72% C 72% D n/a

...Expand

: 109-85-3
2-methoxyethylamine

: 109-86-4
2-methoxy-ethanol

Conditions

Conditions	Yield
With carbonylchloro[4,5-bis(diisopropylphosphinomethyl)acridine]hydridoruthenium(II); water In 1,4-dioxane at 135℃; for 48h; Pressure; Schlenk technique; Inert atmosphere;	66%

: 107-21-1
ethylene glycol

A: 110-91-8
morpholine

B: 109-02-4
4-methyl-morpholine

C: 100-74-3
N-ethylmorpholine;

D: 109-86-4
2-methoxy-ethanol

E: 109-85-3
2-methoxyethylamine

Conditions

Conditions	Yield
With ammonia; hydrogen at 200℃; for 0.00175h; Product distribution; 190 - 260 deg C;	A 46% B 2.1 % Chromat. C 1.4 % Chromat. D 0.7 % Chromat. E 0.6 % Chromat.

...Expand

: 75-21-8
oxirane

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

A: 534-15-6
1,1-dimethoxyethane

B: 109-86-4
2-methoxy-ethanol

C: 6149-41-3
methyl ester (3-hydroxy) propionic acid

D: 27313-49-1
methyl β-(β-hydroxypropionyloxy)propionate

E: 75-07-0
acetaldehyde

Conditions

Conditions	Yield
1H-imidazole; dicobalt octacarbonyl at 60 - 80℃; under 25502.6 - 60006 Torr; for 3 - 4h; Heating / reflux;	A n/a B n/a C 40.2% D n/a E n/a

...Expand

: 646-06-0
1,3-DIOXOLANE

: 100-99-2
triisobutylaluminum

A: 109-86-4
2-methoxy-ethanol

B: 7521-79-1
2-(3-methylbutoxy)-ethanol

Conditions

Conditions	Yield
In dichloromethane at 0 - 20℃;	A 31% B 13%

...Expand

: 1067-52-3
tributyltin methoxide

: 107-07-3
2-chloro-ethanol

A: 109-86-4
2-methoxy-ethanol

B: 1461-22-9
tributyltin chloride

C: 35952-59-1
(C4H9)3SnOCH2CH2Cl

Conditions

Conditions	Yield
byproducts: (CH2CH2O)2;	A 11% B n/a C n/a

...Expand

: 75-21-8
oxirane

: 67-56-1
methanol

: 120-18-3
naphthalene-2-sulfonate

: 109-86-4
2-methoxy-ethanol

...Expand

: 75-21-8
oxirane

: 67-56-1
methanol

: 109-63-7
trifluoroborane diethyl ether

: 109-86-4
2-methoxy-ethanol

Conditions

Conditions	Yield
at -10℃;

...Expand

: 75-21-8
oxirane

: 124-41-4
sodium methylate

: 109-86-4
2-methoxy-ethanol

: 512-56-1
trimethyl phosphite

: 107-21-1
ethylene glycol

: 109-86-4
2-methoxy-ethanol

: 107-21-1
ethylene glycol

: 74-88-4
methyl iodide

: 109-86-4
2-methoxy-ethanol

Conditions

Conditions	Yield
With sodium

: 124-41-4
sodium methylate

: 107-07-3
2-chloro-ethanol

: 109-86-4
2-methoxy-ethanol

: 75-21-8
oxirane

: 593-53-3
Methyl fluoride

: 109-86-4
2-methoxy-ethanol

Conditions

Conditions	Yield
With water; oxygen at 37.5℃; Mechanism; Product distribution; Thermodynamic data; Irradiation; ΔH0;

: 503-30-0
trimethylene oxide

A: 75-21-8
oxirane

B: 107-25-5
methoxyethene

C: 109-86-4
2-methoxy-ethanol

Conditions

Conditions	Yield
With methane; water; oxygen at 37.5℃; Mechanism; Product distribution; Thermodynamic data; Irradiation; ΔH0;

...Expand

: 646-06-0
1,3-DIOXOLANE

: 109-86-4
2-methoxy-ethanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; boron trichloride 1.) CH2Cl2, 0.2 h, 2.) Et2O, 30 min; Yield given. Multistep reaction;

: 109-86-4
2-methoxy-ethanol

: 124-63-0
methanesulfonyl chloride

: 16427-44-4
2-methoxyethyl methanesulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 25℃;	100%
With triethylamine In dichloromethane at 0 - 25℃;	100%
With triethylamine In 1,2-dichloro-ethane at 0 - 20℃; for 12h; Inert atmosphere;	100%

: 109-86-4
2-methoxy-ethanol

: 98-59-9
p-toluenesulfonyl chloride

: 17178-10-8
2-methoxy-ethyl p-toluenesulfonyloxy ester

Conditions

Conditions	Yield
In pyridine at 0℃; for 3.5h;	100%
With triethylamine In dichloromethane at 25℃; for 12h;	97.1%
With triethylamine In toluene at 5 - 30℃;	95%

: 109-86-4
2-methoxy-ethanol

: 3282-30-2
pivaloyl chloride

: 36584-85-7
2-methoxyethyl pivalate

Conditions

Conditions	Yield
at 20℃; for 0.0833333h; Neat (no solvent);	100%
With lanthanum(III) nitrate at 20℃; for 0.25h;	93%
In pyridine; benzene for 2h; Heating;
With pyridine In diethyl ether Heating;

: 109-86-4
2-methoxy-ethanol

: 67617-64-5
N-(2,6-dimethylphenyl)alanine

: 67617-65-6
2-methoxyethyl N-(2,6-dimethylphenyl)alaninate

Conditions

Conditions	Yield
With thionyl chloride	100%

: 1189-71-5
isocyanate de chlorosulfonyle

: 109-86-4
2-methoxy-ethanol

: C4H8ClNO5S

Conditions

Conditions	Yield
In dichloromethane for 1h;	100%

: 1001253-33-3
Methyl 3-((6-amino-2-chloro-9H-purin-9-yl)methyl)benzoate

: 109-86-4
2-methoxy-ethanol

: 1001253-34-4
C16H17N5O4

Conditions

Conditions	Yield
Stage #1: Methyl 3-((6-amino-2-chloro-9H-purin-9-yl)methyl)benzoate; 2-methoxy-ethanol With sodium hydride for 1.5h; Heating / reflux; Stage #2: With hydrogenchloride In water	100%

: 109-86-4
2-methoxy-ethanol

: 358-23-6
trifluoromethylsulfonic anhydride

: 112981-50-7
2-methoxyethyl trifluoromethanesulphonate

Conditions

Conditions	Yield
With 2,6-dimethylpyridine In dichloromethane at 0℃; for 0.25h; Inert atmosphere;	100%
With triethylamine In diethyl ether at -78℃; for 0.75h; Inert atmosphere;	82%
With pyridine In dichloromethane at -70 - 20℃;	66.8%

: 868552-03-8
C17H13ClF2N2O2

: 109-86-4
2-methoxy-ethanol

: 868551-75-1
methyl 1-(4-fluorobenzyl)-3-[(2-methoxyethoxy)methyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In DMF (N,N-dimethyl-formamide) at 40℃; for 24h;	100%

: 109-86-4
2-methoxy-ethanol

: 26412-87-3
sulfur trioxide pyridine complex

: 630393-28-1
pyridinium methoxyethylsulfate

Conditions

Conditions	Yield
at 20℃; for 4h;	100%

: 926296-21-1
ethyl (E)-3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-hydroxy-1H-pyrazol-5-yl}propenoate

: 109-86-4
2-methoxy-ethanol

: 926299-37-8
ethyl (E)-3-[1-[2-chloro-4-(trifluoromethyl)benzyl]-3-(2-methoxyethoxy)-1H-pyrazol-5-yl]propenoate

Conditions

Conditions	Yield
With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine In tetrahydrofuran at 20℃; Mitsunobu reaction;	100%
With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine In tetrahydrofuran at 50℃; for 1h;

: 918643-41-1
3-Fluoro-4-(2-iodothieno[3,2-b]pyridin-7-yloxy)aniline

: 109-86-4
2-methoxy-ethanol

: 99768-12-4
4-methoxycarbonylphenylboronic acid

: 4-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)benzoic acid

Conditions

Conditions	Yield
Stage #1: 3-Fluoro-4-(2-iodothieno[3,2-b]pyridin-7-yloxy)aniline; 2-methoxy-ethanol; 4-methoxycarbonylphenylboronic acid With caesium carbonate; tetrakis(triphenylphosphine) palladium(0) at 90℃; for 48h; Suzuki Coupling; Stage #2: With sodium hydroxide; water for 2h; Stage #3: With hydrogenchloride In water; ethyl acetate	100%

...Expand

: 143323-49-3
(R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate

: 109-86-4
2-methoxy-ethanol

: 950651-24-8
methyl ({[(1,1-dimethylethyl)oxy]carbonyl}amino)(4-{[2-(methyloxy)ethyl]oxy}phenyl)ethanoate

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 5 - 20℃; for 16.25h;	100%

: tantalum pentaisopropoxide

: 109-86-4
2-methoxy-ethanol

: 199010-11-2
Ta(OCH2CH2OCH3)5

Conditions

Conditions	Yield
In 2-methoxy-ethanol (Ar); refluxing (2h); solvent removal (vac.); elem. anal.;	100%

: 109-86-4
2-methoxy-ethanol

: 23894-12-4
6-aminonaphthalen-1-ol

: 924909-28-4
5-(2-methoxyethoxy)naphthalen-2-ylamine

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; for 4h;	100%

: 23056-36-2
2-chloro-4-nitropyridine

: 109-86-4
2-methoxy-ethanol

: 1067914-32-2
2-chloro-4-(2-methoxyethoxy)pyridine

Conditions

Conditions	Yield
With potassium tert-butylate at 0 - 20℃; for 16.5h;	100%
With sodium hydride In tetrahydrofuran at 0 - 25℃; for 10h;	98%
With potassium tert-butylate at 0 - 20℃; for 2h;	97%

: 616-47-7
1-methyl-1H-imidazole

: 109-86-4
2-methoxy-ethanol

: 77-78-1
dimethyl sulfate

: 1,3-dimethylimidazolium 2-methoxyethylsulfate

Conditions

Conditions	Yield
Stage #1: 1-methyl-1H-imidazole; dimethyl sulfate at 0 - 20℃; Stage #2: 2-methoxy-ethanol at 130℃; for 48h;	100%

...Expand

: 812699-95-9
N-{3-[4-(6-chloropyridin-3-yl)-pyrimidin-2-ylamino]-4-methylphenyl}-3-trifluoromethylbenzamide

: 109-86-4
2-methoxy-ethanol

: N-{3-[4-(6-(2-methoxyethoxy)-pyridin-3-yl)-pyrimidin-2-ylamino]-4-methylphenyl}-3-trifluoromethylbenzamide

Conditions

Conditions	Yield
Stage #1: 2-methoxy-ethanol With sodium hydride at 20℃; for 0.5h; Stage #2: N-{3-[4-(6-chloropyridin-3-yl)-pyrimidin-2-ylamino]-4-methylphenyl}-3-trifluoromethylbenzamide at 20℃; for 4h;	100%

: 848470-11-1
6-bromo-N2-(2-ethyl-6-methyl-benzyl)-N4-methyl-3-nitro-pyridine-2,4-diamine

: 109-86-4
2-methoxy-ethanol

: N2-(2-ethyl-6-methyl-benzyl)-6-(2-methoxy-ethoxy)-N4-methyl-3-nitro-pyridine-2,4-diamine

Conditions

Conditions	Yield
Stage #1: 2-methoxy-ethanol With sodium hydride at 0℃; for 0.75h; Stage #2: 6-bromo-N2-(2-ethyl-6-methyl-benzyl)-N4-methyl-3-nitro-pyridine-2,4-diamine for 1.5h; Heating / reflux;	100%

: 109-86-4
2-methoxy-ethanol

: 1258169-42-4
C24H20N2O6S2

: 1258169-46-8
C28H28N2O4

Conditions

Conditions	Yield
Stage #1: 2-methoxy-ethanol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: C24H20N2O6S2 In tetrahydrofuran; mineral oil at 0 - 20℃; Inert atmosphere;	100%

: 109-86-4
2-methoxy-ethanol

: 162012-67-1
N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine

: 402855-06-5
N-(3-chloro-4-fluorophenyl)-7-(2-methoxyethoxy)-6-nitroquinazoline-4-amine

Conditions

Conditions	Yield
Stage #1: 2-methoxy-ethanol With sodium hydride In dimethyl sulfoxide at 40℃; for 2h; Cooling with ice; Stage #2: N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine In dimethyl sulfoxide at 40 - 50℃; for 16h;	100%
Stage #1: 2-methoxy-ethanol With sodium hydride In dimethyl sulfoxide; mineral oil at 40℃; for 2h; Cooling with ice; Inert atmosphere; Stage #2: N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine In dimethyl sulfoxide; mineral oil at 40 - 50℃; for 16h; Inert atmosphere;	100%
Stage #1: 2-methoxy-ethanol With sodium hydride In mineral oil at 0 - 30℃; Stage #2: N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine In mineral oil at 30℃; for 7h;	70.2%
Stage #1: 2-methoxy-ethanol With sodium hydride In tetrahydrofuran at 0 - 20℃; Stage #2: N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine In tetrahydrofuran at 0 - 20℃;
With potassium tert-butylate In dimethyl sulfoxide at 25℃; for 0.5h;

: 109-86-4
2-methoxy-ethanol

: 1600511-80-5
2,5-dichloropyrido[3,4-b]pyrazine

: 1620981-35-2
5-chloro-2-(2-methoxyethoxy)pyrido[3,4-b]pyrazine

Conditions

Conditions	Yield
Stage #1: 2-methoxy-ethanol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.25h; Stage #2: 2,5-dichloropyrido[3,4-b]pyrazine In tetrahydrofuran; mineral oil at 0℃; for 0.333333h;	100%

: 109-86-4
2-methoxy-ethanol

: 2369-13-3
3-fluoro-4-nitroaniline

: 880083-47-6
3-(2-methoxyethoxy)-4-nitroaniline

Conditions

Conditions	Yield
Stage #1: 2-methoxy-ethanol With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 1h; Stage #2: 3-fluoro-4-nitroaniline In tetrahydrofuran; mineral oil at 20℃;	100%

: 109-86-4
2-methoxy-ethanol

: 1-bromo-4-methoxy-10-methyl-6H-benzo[c]chromen-6-one

: 2-methoxyethyl (R)-6'-bromo-2'-hydroxy-3'-methoxy-6-methyl-[1,1'-biphenyl]-2-carboxylate

Conditions

Conditions	Yield
With C29H28F6N4OS at 20℃; for 6h; enantioselective reaction;	100%

: 109-86-4
2-methoxy-ethanol

: diethyl 4-((6-amino-2-chloro-9H-purin-9-yl)methyl)benzylphosphonate

: diethyl 4-((6-amino-2-(2-methoxyethoxy)-9H-purin-9-yl)methyl)benzylphosphonate

Conditions

Conditions	Yield
With sodium hydride In mineral oil at 120℃; for 18h;	100%

: 109-86-4
2-methoxy-ethanol

: 5-(4-bromophenoxymethyl)-2-chloropyridine

: 5-(4-bromophenoxymethyl)-2-(2-methoxyethoxy)pyridine

Conditions

Conditions	Yield
Stage #1: 2-methoxy-ethanol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.416667h; Stage #2: 5-(4-bromophenoxymethyl)-2-chloropyridine In tetrahydrofuran; mineral oil at 70℃; for 18h;	100%

: 109-86-4
2-methoxy-ethanol

: 345-18-6
2-fluoro-5-chloronitrobenzene

: 23987-20-4
1-(4-chloro-2-nitro-phenoxy)-2-methoxy-ethane

Conditions

Conditions	Yield
With potassium hexamethylsilazane In tetrahydrofuran at 0 - 20℃; for 2h; Inert atmosphere;	100%

: 109-86-4
2-methoxy-ethanol

: 8-chloro-2-fluoro-3-methyl-1,5-naphthyridine

: 8-chloro-2-(2-methoxyethoxy)-3-methyl-1,5-naphthyridine

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.166667h;	100%

: 2768-02-7
(vinyl)trimethoxylsilane

: 109-86-4
2-methoxy-ethanol

: 1067-53-4
tris(2-methoxy ethoxy)-vinyl silane

Conditions

Conditions	Yield
With potassium aluminum sulfate at 70 - 80℃; for 2h; Reagent/catalyst;	99.5%

2-Methoxyethanol Consensus Reports

Reported in EPA TSCA Inventory. Community Right-To-Know List.

2-Methoxyethanol Standards and Recommendations

OSHA PEL: TWA 25 ppm (skin)
ACGIH TLV: TWA 5 ppm (skin)
DFG MAK: 5 ppm (16 mg/m³)
NIOSH REL: TWA (Glycol Ethers) Reduce to lowest level
DOT Classification: 3; Label: Flammable Liquid

2-Methoxyethanol Analytical Methods

For occupational chemical analysis use OSHA: #53 or NIOSH: Alcohols IV, 1403.

2-Methoxyethanol Specification

The IUPAC name of Ethylene glycol methyl ether is 2-methoxyethanol. With the CAS registry number 109-86-4, it is also named as Methyl cellosolve. The product's categories are Industrial/Fine Chemicals; Ethylene Glycols & Monofunctional Ethylene Glycols; Monofunctional Ethylene Glycols; Two-component reagents; Amber Glass Bottles; Blends- Chromasolv LC-Mschromasolv Solvents (HPLC, LC-MS); Chromasolv Solvents (HPLC, LC-MS); Chromasolv(R) LC-MSSpectroscopy; LC-MS BlendsSolvents; LC-MS Plus and Gradient; Pre-Blended Mobile Phase Solvents; Solvent Bottles; Water and Water Solutions. Besides, it is clear colorless liquid, which should be stored in a cool, ventilated warehouse at 5 °C. The chemical is stable, but contact with air may lead to the formation of explosive peroxides. In addition, its molecular formula is C₃H₈O₂ and molecular weight is 76.09.

The other characteristics of this product can be summarized as: (1)EINECS: 203-713-7; (2)ACD/LogP: -0.80; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): -0.8; (5)ACD/LogD (pH 7.4): -0.8; (6)ACD/BCF (pH 5.5): 1; (7)ACD/BCF (pH 7.4): 1; (8)ACD/KOC (pH 5.5): 8.77; (9)ACD/KOC (pH 7.4): 8.77; (10)#H bond acceptors: 2; (11)#H bond donors: 1; (12)#Freely Rotating Bonds: 3; (13)Index of Refraction: 1.385; (14)Molar Refractivity: 19.22 cm³; (15)Molar Volume: 81.9 cm³; (16)Surface Tension: 27.6 dyne/cm; (17)Density: 0.928 g/cm³; (18)Flash Point: 46.1 °C; (19)Melting Point: -85 °C; (20)Water Solubility: 1.00E+06 mg/L at 25 °C; (21)Enthalpy of Vaporization: 37.54 kJ/mol; (22)Boiling Point: 124.4 °C at 760 mmHg; (23)Vapour Pressure: 5.98 mmHg at 25 °C.

Preparation of Ethylene glycol methyl ether: this chemical can be prepared by the reaction of Ethylene oxide with Methanol.

This reaction will occur at high temperature and pressure.

Uses of Ethylene glycol methyl ether: this chemical is the intermediate of cinosulfuron. It is also a solvent of fats and oils nitro cellulose and synthetic resin. And it can be used as as paint solvent, penetrant, leveling agent. Moreover, it is used as an intermediate in organic synthesis. The product is used as an additive of jet fuel. Additionally, it can be used for the determination of iron, sulfate and Carbon disulfide.

When you are using this chemical, please be cautious about it as the following: it is highly flammable that may cause severe burns.Please keep away from sources of ignition. It is also harmful by inhalation, in contact with skin and if swallowed. And it is toxic by inhalation, in contact with skin and if swallowed. Please do not breathe vapour. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Furthermore, you should wear suitable protective clothing and gloves. And in case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible). What's more, it is danger of very serious irreversible effects that may cause harm to the unborn child. Similarly, it may impair fertility. You should avoid exposure - obtain special instructions before use.

People can use the following data to convert to the molecule structure.
(1)Canonical SMILES: COCCO
(2)InChI: InChI=1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3
(3)InChIKey: XNWFRZJHXBZDAG-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	oral	950mg/kg (950mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES	Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.
human	LDLo	oral	3380mg/kg (3380mg/kg)	GASTROINTESTINAL: GASTRITIS LIVER: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES	Journal of Industrial Hygiene and Toxicology. Vol. 28, Pg. 267, 1946.
human	TCLo	inhalation	25ppm (25ppm)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Journal of Industrial Hygiene and Toxicology. Vol. 20, Pg. 134, 1938.
mouse	LC50	inhalation	1480ppm/7H (1480ppm)	BEHAVIORAL: ANALGESIA KIDNEY, URETER, AND BLADDER: HEMATURIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Journal of Industrial Hygiene and Toxicology. Vol. 25, Pg. 157, 1943.
mouse	LD50	intraperitoneal	2147mg/kg (2147mg/kg)	KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI BLOOD: CHANGES IN SPLEEN BLOOD: OTHER CHANGES	Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 342, 1947.
mouse	LD50	oral	2560mg/kg (2560mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) CARDIAC: OTHER CHANGES BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(3), Pg. 48, 1988.
rabbit	LD50	oral	890mg/kg (890mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA	AMA Archives of Industrial Health. Vol. 14, Pg. 114, 1956.
rabbit	LD50	skin	1280mg/kg (1280mg/kg)		Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 57, 1974.
rat	LC50	inhalation	1500ppm/7H (1500ppm)		Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 57, 1974.
rat	LD50	intraperitoneal	2500mg/kg (2500mg/kg)		Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 57, 1974.
rat	LD50	intravenous	2068mg/kg (2068mg/kg)	BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA	AMA Archives of Industrial Health. Vol. 14, Pg. 114, 1956.
rat	LD50	oral	2370mg/kg (2370mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Veterinary and Human Toxicology. Vol. 29, Pg. 361, 1987.

Product Name

2-Methoxyethanol

Synthetic route

2-Methoxyethanol Consensus Reports

2-Methoxyethanol Standards and Recommendations

2-Methoxyethanol Analytical Methods

2-Methoxyethanol Specification

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