3-(Methylamino)-1-propanol supplier

Name
3-(METHYLAMINO)-1-PROPANOL
EINECS
CAS No. 42055-15-2
Article Data38
CAS DataBase
Density 0.917
Solubility Slightly soluble in water.
Melting Point
Formula C4H11 N O
Boiling Point 169oC
Molecular Weight 89.1374
Flash Point 82oC
Transport Information
Appearance
Safety
Risk Codes R22; R34
Molecular Structure
Hazard Symbols
Synonyms (3-Hydroxypropyl)methylamine;3-(Methylamino)-1-propanol; 3-(Methylamino)propanol;3-(N-Methylamino)-1-propanol; 3-(N-Methylamino)propanol; AMP-P 5;N-(3-Hydroxypropyl)-N-methylamine; N-(3-Hydroxypropyl)methylamine;N-Methyl-3-aminopropanol; N-Methylpropanolamine; g-(Methylamino)propanol
PSA 32.26000
LogP -0.02090

Synthetic route

: 98642-44-5
tert-butyl (3-hydroxypropyl)methylcarbamate

: 42055-15-2
N-methyl-3-hydroxypropylamine

Conditions

Conditions	Yield
With hydrogenchloride for 17h;	100%

: 49807-74-1
3-(N-formylamino)propan-1-ol

: 42055-15-2
N-methyl-3-hydroxypropylamine

Conditions

Conditions	Yield
With potassium hydroxide	86.6%
Stage #1: N-(3-hydroxypropyl)formamide With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 5h; Heating / reflux; Stage #2: With potassium hydroxide; water In tetrahydrofuran for 0.5h; Heating / reflux;	86.6%
With lithium aluminium tetrahydride In diethyl ether at 25℃; for 15h;	84%

: 74-89-5
methylamine

: 627-30-5
1-chloro-3-hydroxypropane

: 42055-15-2
N-methyl-3-hydroxypropylamine

Conditions

Conditions	Yield
In ethanol at 20℃; for 144h;	65%
In ethanol at 25℃; for 15h;	40%
In water at 0 - 30℃; for 17h;	100.4 g

3-(N-benzyl-N-methylamino)-propan-1-ol: 3-(N-benzyl-N-methylamino)-propan-1-ol

: 42055-15-2
N-methyl-3-hydroxypropylamine

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In ethanol at 60℃; under 15201 Torr; for 4h; Autoclave;	61%
With hydrogen; nickel In ethanol

: 2213-08-3
ethyl 3-methylaminopropionate

: 42055-15-2
N-methyl-3-hydroxypropylamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran	56%
With lithium aluminium tetrahydride
With lithium aluminium tetrahydride In diethyl ether Heating;

N-methyl-3-hydroxypropylamine: N-methyl-3-hydroxypropylamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 80℃; for 32.5h;	50%

: 79-22-1
methyl chloroformate

: 156-87-6
propan-1-ol-3-amine

: 42055-15-2
N-methyl-3-hydroxypropylamine

Conditions

Conditions	Yield
With sodium carbonate In dichloromethane 1.) 10 deg C, 2.) reflux;	37%

: 503-30-0
trimethylene oxide

: 74-89-5
methylamine

: 42055-15-2
N-methyl-3-hydroxypropylamine

Conditions

Conditions	Yield
With water at 150℃;
With water

: 42050-46-4
methyl-carbamic acid-(3-chloro-propyl ester)

: 42055-15-2
N-methyl-3-hydroxypropylamine

Conditions

Conditions	Yield
With potassium hydroxide

: 107-18-6
allyl alcohol

: 74-89-5
methylamine

: 42055-15-2
N-methyl-3-hydroxypropylamine

Conditions

Conditions	Yield
With sodium 2-propenoate at 120 - 150℃;

: 107-18-6
allyl alcohol

: 74-89-5
methylamine

A: 42055-15-2
N-methyl-3-hydroxypropylamine

B: 2158-67-0
3,3'-(methylazanediyl)bis(propan-1-ol)

Conditions

Conditions	Yield
With sodium 2-propenoate at 120 - 150℃;

...Expand

: 156-87-6
propan-1-ol-3-amine

: 74-88-4
methyl iodide

: 42055-15-2
N-methyl-3-hydroxypropylamine

Conditions

Conditions	Yield
In methanol Heating;

: 77-78-1
dimethyl sulfate

: 156-87-6
propan-1-ol-3-amine

A: 42055-15-2
N-methyl-3-hydroxypropylamine

B: 3179-63-3
3-Dimethylamino-1-propanol

Conditions

Conditions	Yield
With lithium hydride 1.) THF, room temp., 1 h; 2.) room temp., 1 h; Yield given. Multistep reaction;
With calcium hydride 1.) THF, room temp., 2.) room temp., 1 h; Yield given. Multistep reaction;

...Expand

: 98056-36-1
diethylphosphoramidate de N-methyle et de N-(hydroxy-3 propyle)

: 42055-15-2
N-methyl-3-hydroxypropylamine

Conditions

Conditions	Yield
With hydrogenchloride In water for 12h; Heating;

: 98056-38-3
diethylthiophosphoramidate de N-methyle et de N-(hydroxy-3 propyle)

: 42055-15-2
N-methyl-3-hydroxypropylamine

Conditions

Conditions	Yield
With hydrogenchloride In water for 12h; Heating;

: 98056-40-7
bis-dimethylphosphoramide de N-methyle et de N-(hydroxy-3 propyle)

: 42055-15-2
N-methyl-3-hydroxypropylamine

Conditions

Conditions	Yield
With hydrogenchloride In water for 12h; Heating;

: 42050-46-4
methyl-carbamic acid-(3-chloro-propyl ester)

alcoholic KOH-solution: alcoholic KOH-solution

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 593-51-1
methylamine hydrochloride

: 107-18-6
allyl alcohol

sodium: sodium

A: 42055-15-2
N-methyl-3-hydroxypropylamine

B: 2158-67-0
3,3'-(methylazanediyl)bis(propan-1-ol)

...Expand

: 67-56-1
methanol

: 156-87-6
propan-1-ol-3-amine

A: 42055-15-2
N-methyl-3-hydroxypropylamine

B: 3179-63-3
3-Dimethylamino-1-propanol

Conditions

Conditions	Yield
With Cs-P-Si mixed-oxide at 300℃; under 61504.9 Torr; Title compound not separated from byproducts;

...Expand

: 67-56-1
methanol

: 156-87-6
propan-1-ol-3-amine

: 42055-15-2
N-methyl-3-hydroxypropylamine

Conditions

Conditions	Yield
With Cs-P-Si at 300℃; under 61504.9 Torr;
With mesoporous Cs-B-Zr mixed oxide In neat (no solvent) at 220℃; under 32253.2 Torr; for 0.5h; Autoclave; Inert atmosphere; Green chemistry;

: 627-30-5
1-chloro-3-hydroxypropane

: 42055-15-2
N-methyl-3-hydroxypropylamine

Conditions

Conditions	Yield
Stage #1: 1-chloro-3-hydroxypropane With methylamine In water for 72h; Heating / reflux; Stage #2: With potassium carbonate In water at 20℃; Product distribution / selectivity;
Stage #1: 1-chloro-3-hydroxypropane With methylamine; sodium iodide In water at 20℃; for 17h; Stage #2: With potassium carbonate In water at 20℃; Product distribution / selectivity;

: 58885-60-2
N-(tert-butoxycarbonyl)-3-aminopropanal

: 42055-15-2
N-methyl-3-hydroxypropylamine

Conditions

Conditions	Yield
Stage #1: N-(tert-butoxycarbonyl)-3-aminopropanal With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 17.3333h; Reflux; Inert atmosphere; Stage #2: With sodium sulfate decahydrate In tetrahydrofuran at 20℃; Inert atmosphere;

: 74-89-5
methylamine

: 627-18-9
1-bromo-3-propanol

: 42055-15-2
N-methyl-3-hydroxypropylamine

Conditions

Conditions	Yield
In water at 20℃; for 14h; Cooling with ice;	6 g

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 243982-49-2
3-Chloro-4-((R)-3,3,3-trifluoro-2-hydroxy-2-methyl-propionylamino)-benzoic acid

: 3-chloro-N-(3-hydroxy-propyl)-N-methyl-4-(3,3,3-trifluoro-2-hydroxy-2-methyl-propionylamino)-benzamide

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 18h; Acylation;	100%

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 24424-99-5
di-tert-butyl dicarbonate

: 98642-44-5
tert-butyl (3-hydroxypropyl)methylcarbamate

Conditions

Conditions	Yield
With 1-methylimidazolium tetrafluoroborate at 30 - 35℃; for 0.0833333h;	100%
With triethylamine In dichloromethane at 20℃; for 11h;	100%
With triethylamine In methanol at 20℃;	99%

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 1419843-78-9
(9H-fluoren-9-yl)methyl 3-hydroxypropylmethylcarbamate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at -18℃; Cooling with ice;	100%

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 40662-29-1
3-methyl-3-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-butyric acid

: 1426551-48-5
N-(3-hydroxypropyl)-N,3-dimethyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide

Conditions

Conditions	Yield
Stage #1: 3-methyl-3-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-butyric acid With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at 0℃; for 0.5h; Stage #2: N-methyl-3-hydroxypropylamine In tetrahydrofuran at 20℃;	100%

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 3,3'-bis(3-bromopropoxy)-2,2'-dimethyl-1,1'-biphenyl

: 3,3'-((((2,2'-dimethyl-[1,1'-biphenyl]-3,3'-diyl)bis(oxy))bis(propane-3,1-diyl))bis(methylazanediyl))bis(propan-1-ol)

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In methanol at 65℃; for 18h; Inert atmosphere;	100%

: 16234-14-3
2,4-dichlorothieno[3,2-d]pyrimidine

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 3-((2-chlorothieno[3,2-d]pyrimidin-4-yl)(methyl)amino)propan-1-ol

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In ethyl acetate at 20℃;	99%

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 1943-67-5
4-(t-butyl)phenyl isocyanate

: 1381761-31-4
C15H24N2O2

Conditions

Conditions	Yield
Stage #1: N-methyl-3-hydroxypropylamine; 4-(t-butyl)phenyl isocyanate In dichloromethane at 20℃; Stage #2: With hydrogenchloride In dichloromethane	98%

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 615-18-9
2-chloro-1,3-benzoxazole

: 122321-02-2
3-(benzooxazol-2-ylmethylamino)propan-1-ol

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 60 - 70℃; for 2h; Inert atmosphere;	97%
With triethylamine In tetrahydrofuran at 0 - 20℃; for 3h;
With triethylamine In tetrahydrofuran; dichloromethane
With triethylamine In tetrahydrofuran; dichloromethane

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 104-88-1
4-chlorobenzaldehyde

: 138609-41-3
3-methyl-2-(4-chlorophenyl)tetrahydro-1,3-oxazine

Conditions

Conditions	Yield
In benzene Heating;	96%

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 70415-59-7
N-methyl-N-nitroso-3-hydroxypropylamine

Conditions

Conditions	Yield
With tert.-butylnitrite In tetrahydrofuran Heating;	95%
With hydrogenchloride; sodium nitrite
With tert.-butylnitrite

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 24424-99-5
di-tert-butyl dicarbonate

: 3-([N-(tert-butylcarbonyl)-N-methyl]amino)-1-propanol

Conditions

Conditions	Yield
In tetrahydrofuran; water	95%

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 3-((tert-butyldimethylsilyl)oxy)-N-methylpropan-1-amine

Conditions

Conditions	Yield
With 1H-imidazole In dichloromethane at 20℃; for 12h;	92%
With 1H-imidazole In dichloromethane at 0 - 20℃;	52.6%

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 398489-26-4
tert-butyl 3-oxoazetidine-1-carboxylate

: tert-butyl 3-((3-hydroxypropyl)(methyl)amino)azetidine-1-carboxylate

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride In dichloromethane at 25℃; for 16h;	91.2%

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 15568-85-1
5-methoxymethylene-2,2-dimethyl-1,3-dioxane-4,6-dione

: 5-{[(3-Hydroxy-propyl)-methyl-amino]-methylene}-2,2-dimethyl-[1,3]dioxane-4,6-dione

Conditions

Conditions	Yield
In acetonitrile for 8h; Heating;	90%

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 501-53-1
benzyl chloroformate

: benzyl 3-hydroxypropyl(methyl)carbamate

Conditions

Conditions	Yield
β‐cyclodextrin In water at 20℃; for 0.05h;	89%
With sodium hydroxide In 1,4-dioxane; water at 50℃; for 0.5h;	82.6%
With potassium hydroxide In 1,4-dioxane; water for 1h; pH=10;	82%

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 79-22-1
methyl chloroformate

: 958255-17-9
methyl (3-hydroxypropyl)(methyl)carbamate

Conditions

Conditions	Yield
With potassium carbonate In acetone for 12h; Heating;	89%

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 1073-06-9
3-fluorobromobenzene

: 1248231-90-4
N-methyl-N-(3-hydroxyl-1-propyl)-3-fluoroaniline

Conditions

Conditions	Yield
With potassium phosphate; copper(l) iodide; CVT-2537 In butan-1-ol at 110℃; for 15h; Inert atmosphere; chemoselective reaction;	87%

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 57054-92-9
5-bromo-2-chloro-4-methoxypyrimidine

: 3-((5-bromo-4-methoxypyrimidin-2-yl)(methyl)amino)propan-1-ol

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 80℃; for 16h;	87%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 80℃; for 16h; Inert atmosphere;	87%

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 345-92-6
4,4'-Difluorobenzophenone

: 4-fluoro-4'-N-(methyl-3-hydroxypropylamino)benzophenone

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium carbonate In dimethyl sulfoxide at 100℃; for 48h;	86%

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 98-88-4
benzoyl chloride

: 41880-26-6
N-(3-hydroxylpropyl)-N-methylbenzamide

Conditions

Conditions	Yield
With trimethylamine In tetrahydrofuran at 0℃; Inert atmosphere;	86%

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 65232-62-4
methyl-3-chloropropylamine

Conditions

Conditions	Yield
With thionyl chloride at 0 - 20℃;	86%

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 5784-45-2
1-chlorophthalazine

: 126650-64-4
1-phthalazine

Conditions

Conditions	Yield
In ethanol for 6h; Heating;	85%

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 104-92-7
1-bromo-4-methoxy-benzene

: 1251248-66-4
N-methyl-N-(3-hydroxyl-1-propyl)-4-methoxyaniline

Conditions

Conditions	Yield
With potassium phosphate; copper(l) iodide; CVT-2537 In butan-1-ol at 110℃; for 15h; Inert atmosphere; chemoselective reaction;	85%

: 4-(4-((benzyloxy)carbonyl)-1,4-diazepan-1-yl)benzoic acid

: 42055-15-2
N-methyl-3-hydroxypropylamine

: benzyl 4-(4-((3-hydroxypropyl)(methyl)carbamoyl)phenyl)-1,4-diazepane-1-carboxylate

Conditions

Conditions	Yield
Stage #1: 4-{4-[(benzyloxy)carbonyl]-1,4-diazepan-1-yl}benzoic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 0.333333h; Stage #2: N-methyl-3-hydroxypropylamine In dichloromethane at 20℃; for 4h;	85%

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 7515-46-0
(E)-(4-chlorobut-1-en-1-yl)benzene

: 112403-53-9
3-amino>-1-propanol

Conditions

Conditions	Yield
With potassium carbonate In ethanol for 168h; Heating;	84%

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 207399-07-3
2-[2-[2-chloro-3-[(1,3-dihydro-3,3-dimethyl-1-propyl-2H-indolyl-2-ylidenyl)ethylidenyl]-1-cyclohexen-1-yl]ethenyl]-3,3-dimethyl-1-propylindolium iodide

: C40H54N3O(1+)*I(1-)

Conditions

Conditions	Yield
In acetonitrile at 80℃; for 0.166667h; Inert atmosphere;	84%
In acetonitrile at 80℃; for 0.166667h; Sealed tube;	84%

: 42055-15-2
N-methyl-3-hydroxypropylamine

: 35444-44-1
methyl adipoyl chloride

: 1185730-64-6
methyl 6-((3-hydroxypropyl)(methyl)amino)-6-oxohexanoate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane Inert atmosphere;	82%
With N-ethyl-N,N-diisopropylamine In dichloromethane at -78 - 0℃; Inert atmosphere;	42%
In dichloromethane at -78 - 0℃; Inert atmosphere;	42%

: 42055-15-2
N-methyl-3-hydroxypropylamine

: C9H12Cl2N(1+)*CF3O3S(1-)

: 85507-24-0
N-methyl-3-(2,4-dichlorophenoxy)propylamine

Conditions

Conditions	Yield
Stage #1: N-methyl-3-hydroxypropylamine With potassium hexamethylsilazane In tetrahydrofuran; N,N-dimethyl-formamide at 25℃; for 0.166667h; Inert atmosphere; Schlenk technique; Stage #2: C9H12Cl2N(1+)*CF3O3S(1-) In tetrahydrofuran; N,N-dimethyl-formamide at 25℃; for 3h; Inert atmosphere; Schlenk technique;	82%

3-(Methylamino)-1-propanol Chemical Properties

Product Name: 3-(Methylamino)-1-propanol
Molecular Structure:

Molecular Formula: C₄H₁₁NO
Molecular Weight: 89.1362
Synonyms of 3-(Methylamino)-1-propanol (CAS NO.42055-15-2): N-(Methylamino)-1-propanol ; 3-(Methylamino)propane-1-ol
CAS NO: 42055-15-2
Index of Refraction: 1.423
Molar Refractivity: 25.71 cm³
Molar Volume: 100.885 cm³
Surface Tension: 29.938 dyne/cm
Density: 0.884 g/cm³
Flash Point: 82.21 °C
Enthalpy of Vaporization: 46.647 kJ/mol
Boiling Point: 164.048 °C at 760 mmHg
Vapour Pressure of 3-(Methylamino)-1-propanol (CAS NO.42055-15-2): 0.679 mmHg at 25°C

3-(Methylamino)-1-propanol Safety Profile

Hazard Codes of 3-(Methylamino)-1-propanol (CAS NO.42055-15-2): Corrosive C
Risk Statements: 10-34-22
R10: Flammable.
R34: Causes burns.
R22: Harmful if swallowed.
Safety Statements: 16-36/37/39-45-26
S16: Keep away from sources of ignition.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: 2735

Product Name

3-(METHYLAMINO)-1-PROPANOL

Synthetic route

3-(Methylamino)-1-propanol Chemical Properties

3-(Methylamino)-1-propanol Safety Profile

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