Product Name

  • Name

    3-Chlorosalicylic acid

  • EINECS 217-379-5
  • CAS No. 1829-32-9
  • Article Data35
  • CAS DataBase
  • Density 1.536 g/cm3
  • Solubility
  • Melting Point 184-186 ºC
  • Formula C7H5ClO3
  • Boiling Point 291.7 ºC at 760 mmHg
  • Molecular Weight 172.568
  • Flash Point 130.2 ºC
  • Transport Information
  • Appearance White Solid
  • Safety S26;S36
  • Risk Codes R36/37/38   
  • Molecular Structure Molecular Structure of 1829-32-9 (3-Chlorosalicylic acid)
  • Hazard Symbols
  • Synonyms 3EINECS 217-379-5;NSC 18854;Benzoic acid, 3-chloro-2-hydroxy- (9CI);Salicylic acid, 3-chloro- (8CI);
  • PSA 57.53000
  • LogP 1.74380

Synthetic route

3-chloro-2-hydroxy-thiobenzoic acid S-methyl ester
116025-20-8

3-chloro-2-hydroxy-thiobenzoic acid S-methyl ester

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

Conditions
ConditionsYield
With lithium hydroxide In methanol at 20℃; for 6h;100%
carbon dioxide
124-38-9

carbon dioxide

chloro-1 methoxymethylenoxy-2 benzene
27701-22-0

chloro-1 methoxymethylenoxy-2 benzene

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

Conditions
ConditionsYield
Stage #1: chloro-1 methoxymethylenoxy-2 benzene With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 1.5h;
Stage #2: carbon dioxide In tetrahydrofuran; hexane at -78℃; for 1.5h;
Stage #3: With hydrogenchloride In tetrahydrofuran; hexane at 20℃;
91%
2,3-dichlorbenzoic acid
50-45-3

2,3-dichlorbenzoic acid

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

Conditions
ConditionsYield
With pyridine; copper; potassium carbonate In water for 2h; Heating;85%
With copper(l) iodide; copper; potassium carbonate at 180℃; under 7355.08 Torr;
N-(4-fluorophenyl)glycine potassium salt

N-(4-fluorophenyl)glycine potassium salt

A

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

B

N-(4-fluorophenyl)-N-(2-carboxyphenyl)glycin
180911-99-3

N-(4-fluorophenyl)-N-(2-carboxyphenyl)glycin

Conditions
ConditionsYield
Stage #1: N-(4-fluorophenyl)glycine potassium salt With potassium 2,5-dichlorobenzoate; copper; potassium carbonate In water for 20.5h; Heating / reflux;
Stage #2: With hydrogenchloride In water at 75 - 80℃; for 0.5h;
A n/a
B 80.3%
2-monochlorophenol
95-57-8

2-monochlorophenol

sodium ethyl carbonate
17201-44-4

sodium ethyl carbonate

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

Conditions
ConditionsYield
With carbon dioxide at 190℃; under 7600.51 Torr; for 6h; Autoclave; regioselective reaction;68.2%
carbon dioxide
124-38-9

carbon dioxide

2-monochlorophenol
95-57-8

2-monochlorophenol

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

Conditions
ConditionsYield
Stage #1: 2-monochlorophenol With Mesitol; sodium hydride In mineral oil at 100℃; for 0.0833333h; Glovebox;
Stage #2: carbon dioxide In mineral oil at 185℃; under 3800.26 Torr; for 2h;
55%
With potassium carbonate at 170℃; under 29420.3 Torr;
3-chloro-2-hydroxy-benzoic acid-(2,2,2-trichloro-1-hydroxy-ethylamide)
873975-79-2

3-chloro-2-hydroxy-benzoic acid-(2,2,2-trichloro-1-hydroxy-ethylamide)

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

Conditions
ConditionsYield
With sodium hydroxide
salicylic acid disodium salt
54-21-7, 13639-21-9, 79211-80-6

salicylic acid disodium salt

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

Conditions
ConditionsYield
With sodium hypochlorite
5-sulfosalicylic Acid
97-05-2

5-sulfosalicylic Acid

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

Conditions
ConditionsYield
With chlorine; acetic acid Behandeln des Reaktionsprodukts mit ueberhitztem Wasserdampf;
With hydrogenchloride; potassium permanganate Behandeln des Reaktionsprodukts mit ueberhitztem Wasserdampf;
tetrachloromethane
56-23-5

tetrachloromethane

tert-butylhypochlorite
507-40-4

tert-butylhypochlorite

salicylic acid
69-72-7

salicylic acid

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

tert-butylhypochlorite
507-40-4

tert-butylhypochlorite

salicylic acid
69-72-7

salicylic acid

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

Conditions
ConditionsYield
With tetrachloromethane
salicylic acid
69-72-7

salicylic acid

A

5-chloro-2-hydroxybenzoic acid
321-14-2

5-chloro-2-hydroxybenzoic acid

B

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

Conditions
ConditionsYield
With sodium carbonate bei der Chlorierung;
With sodium hydroxide; sodium hypochlorite at 20℃; for 2.5h; pH > 12; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With N-chlorotriethylammonium chloride In trifluoroacetic acid Ambient temperature; Yield given. Yields of byproduct given;
3-chlorosalicylaldehyde
1927-94-2

3-chlorosalicylaldehyde

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

Conditions
ConditionsYield
With sodium hydroxide; potassium permanganate Heating;
2-amino-3-chlorobenzoic acid
6388-47-2

2-amino-3-chlorobenzoic acid

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

Conditions
ConditionsYield
With copper(II) sulfate 1.) diazotized; Yield given. Multistep reaction;
dipotassium 5-chlorosalicyl sulphate

dipotassium 5-chlorosalicyl sulphate

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

Conditions
ConditionsYield
With HCl-chloroacetate; potassium chloride at 70℃; Rate constant; dependence on pH;
7-chloro-1,1-dioxo-1,2-dihydro-1λ6-benzo[d]isothiazol-3-one
89999-91-7

7-chloro-1,1-dioxo-1,2-dihydro-1λ6-benzo[d]isothiazol-3-one

water
7732-18-5

water

sodium hydroxide

sodium hydroxide

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

Conditions
ConditionsYield
beim Schmelzen;
chlorine
7782-50-5

chlorine

acetic acid
64-19-7

acetic acid

5-sulfosalicylic Acid
97-05-2

5-sulfosalicylic Acid

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

Conditions
ConditionsYield
Behandeln des Reaktionsprodukts mit Wasserdampf;
carbon dioxide
124-38-9

carbon dioxide

2-chloro-phenol sodium

2-chloro-phenol sodium

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

Conditions
ConditionsYield
at 140 - 150℃; im Autoklaven;
2-hydroxy-1-carboxy-benzenediazonium-(3)-betaine

2-hydroxy-1-carboxy-benzenediazonium-(3)-betaine

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

Conditions
ConditionsYield
With hydrogenchloride Sonnenlicht;
sodium salicylate
54-21-7

sodium salicylate

chlorine
7782-50-5

chlorine

natrium carbonate

natrium carbonate

A

5-chloro-2-hydroxybenzoic acid
321-14-2

5-chloro-2-hydroxybenzoic acid

B

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

3-chloro-2-methoxymethoxy-benzoic acid

3-chloro-2-methoxymethoxy-benzoic acid

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

Conditions
ConditionsYield
With hydrogenchloride In water pH=1;3.19 g
3-chlorobenzoate
535-80-8

3-chlorobenzoate

A

5-chloro-2-hydroxybenzoic acid
321-14-2

5-chloro-2-hydroxybenzoic acid

B

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

Conditions
ConditionsYield
Stage #1: 3-chlorobenzoate With [bis(acetonitrile)(N,N'-dimethyl-N,N'-bis(2-pyridylmethyl)-1,2-diaminoethane)iron(II)] perchlorate; dihydrogen peroxide In acetonitrile at 20℃; for 0.333333h;
Stage #2: With hydrogenchloride In acetonitrile
With [Fe(II)(N,N'-dimethyl-N,N'-bis(2-pyridylmethyl)-1,2-ethylenediamine)(CH3CN)2](ClO4)2; dihydrogen peroxide In water; acetonitrile at 20℃; Inert atmosphere; regioselective reaction;
chloro-1 methoxymethylenoxy-2 benzene
27701-22-0

chloro-1 methoxymethylenoxy-2 benzene

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: butyllithium / tetrahydrofuran; hexane / 6 h / -75 °C
1.2: tetrahydrofuran; hexane
2.1: 3.19 g / HCl / H2O / pH 1
View Scheme
2-monochlorophenol
95-57-8

2-monochlorophenol

(+-)-ethylphosphonic acid ethyl ester chloride

(+-)-ethylphosphonic acid ethyl ester chloride

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: BCl3; AlCl3 / 1,2-dichloro-ethane / 4 h / 20 °C
1.2: 51 percent / aq. HCl / 1,2-dichloro-ethane / 0.17 h / 20 °C
2.1: 100 percent / aq. LiOH / methanol / 6 h / 20 °C
View Scheme
2-monochlorophenol
95-57-8

2-monochlorophenol

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 96 percent / NaH / tetrahydrofuran; methyl acetate / 2 h / 0 - 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 1.5 h / 0 °C
2.2: tetrahydrofuran; hexane / 1.5 h / -78 °C
2.3: 91 percent / 6M HCl / tetrahydrofuran; hexane / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: (i) aq. NaOH, (ii) /BRN= 1731042/
2: KMnO4, aq. NaOH / Heating
View Scheme
Multi-step reaction with 4 steps
1.1: 1H-imidazole / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: water; sodium hydrogencarbonate / N,N-dimethyl-formamide; diethyl ether / 0.5 h / 20 °C / Inert atmosphere
3.1: palladium diacetate; silver(I) acetate; N-tert-butoxycarbonyl-L-leucine; 2,2,2-trifluoroethanol / 1,2-dichloro-ethane / 0.08 h / 95 °C / Inert atmosphere
3.2: 18 h / 95 °C / Inert atmosphere
3.3: 18 h / 95 °C / Inert atmosphere; Glovebox
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / Inert atmosphere
View Scheme
3-chloro-2-nitro-benzoic acid
4771-47-5

3-chloro-2-nitro-benzoic acid

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 72 percent / tin, hydrochloric acid
2: 2.) CuSO4 / 1.) diazotized
View Scheme
potassium 2,5-dichlorobenzoate

potassium 2,5-dichlorobenzoate

N-(4-fluorophenyl)glycine potassium salt

N-(4-fluorophenyl)glycine potassium salt

A

N-(4-fluorophenyl)-N-(2-carboxy-4-chlorophenyl)glycine

N-(4-fluorophenyl)-N-(2-carboxy-4-chlorophenyl)glycine

B

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

Conditions
ConditionsYield
With potassium carbonate; copper In water at 50℃; for 15 - 20.5h; Heating / reflux; Industry scale;
2-monochlorophenol
95-57-8

2-monochlorophenol

potassium hydrogencarbonate
298-14-6

potassium hydrogencarbonate

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

Conditions
ConditionsYield
With 2,3-dihydroxybenzoate decarboxylase from Aspergillus oryzae In aq. phosphate buffer at 30℃; for 24h; Kolbe-Schmidt Synthesis; Enzymatic reaction; regioselective reaction;
salicylic acid
69-72-7

salicylic acid

A

5-chloro-2-hydroxybenzoic acid
321-14-2

5-chloro-2-hydroxybenzoic acid

B

3,5-dichlorosalicylic acid
320-72-9

3,5-dichlorosalicylic acid

C

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

Conditions
ConditionsYield
With sodium hypochlorite In methanol; water
3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

methyl iodide
74-88-4

methyl iodide

methyl 3-chloro-2-methoxybenzoate

methyl 3-chloro-2-methoxybenzoate

Conditions
ConditionsYield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 80℃; for 23h;100%
With potassium carbonate In N-methyl-acetamide
formaldehyd
50-00-0

formaldehyd

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

3,3'-dicarboxy-5,5'-dichloro-4,4'-dihydroxydiphenylmethane
128626-47-1

3,3'-dicarboxy-5,5'-dichloro-4,4'-dihydroxydiphenylmethane

Conditions
ConditionsYield
With sulfuric acid In methanol; water 1.)0 deg C, 1h 2.) r. t., 24h;96%
With sulfuric acid In methanol; water at -5 - 0℃; for 24.3333h;92%
With sulfuric acid; water In methanol at -5 - 20℃; for 26h;92%
3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

2-amino-benzenethiol
137-07-5

2-amino-benzenethiol

2-(2'-Hydroxy-3'-chlorophenyl)benzothiazole
90481-39-3

2-(2'-Hydroxy-3'-chlorophenyl)benzothiazole

Conditions
ConditionsYield
With phosphorus trichloride In toluene for 4h; Heating;94%
With phosphorus trichloride In toluene at 100℃;45%
2,2,2-trifluoroethanol
75-89-8

2,2,2-trifluoroethanol

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

C9H6ClF3O3

C9H6ClF3O3

Conditions
ConditionsYield
With thionyl chloride for 6h; Inert atmosphere; Reflux;82%
2-iodo-propane
75-30-9

2-iodo-propane

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

3-chloro-2-isopropoxybenzoic acid isopropyl ester
894851-25-3

3-chloro-2-isopropoxybenzoic acid isopropyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 66h;77%
3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

acetic anhydride
108-24-7

acetic anhydride

2-(acetylocy)-3-chlorobenzoic acid
16534-19-3

2-(acetylocy)-3-chlorobenzoic acid

Conditions
ConditionsYield
Stage #1: 3-Chloro-2-hydroxybenzoic acid; acetic anhydride With triethylamine In tetrahydrofuran at 20℃; for 22.5h;
Stage #2: With hydrogenchloride In water
76%
With sulfuric acid at 140℃; for 2h;43%
With sulfuric acid
With sulfuric acid In water at 20℃; Heating;
3-aminoquinoline
580-17-6

3-aminoquinoline

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

3-chloro-2-hydroxy-N-(quinolin-3-yl)benzamide
1257883-68-3

3-chloro-2-hydroxy-N-(quinolin-3-yl)benzamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 40℃; for 8h;76%
3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

2-(2'-Hydroxy-3'-chlorophenyl)benzimidazole
96459-82-4

2-(2'-Hydroxy-3'-chlorophenyl)benzimidazole

Conditions
ConditionsYield
With PPA at 150℃;75%
orcinol
504-15-4

orcinol

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

5-chloro-1-hydroxy-3-methyl-9H-xanthen-9-one

5-chloro-1-hydroxy-3-methyl-9H-xanthen-9-one

Conditions
ConditionsYield
With methanesulfonic acid; phosphorus pentoxide at 90℃;71%
2-(4-pyridylmethylene amino) ethanol
106782-22-3

2-(4-pyridylmethylene amino) ethanol

Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

C22H26ClN3O4
917890-17-6

C22H26ClN3O4

Conditions
ConditionsYield
With 3 A molecular sieve In methanol at 20℃; Ugi reaction;64%
Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

(E)-2-(benzylideneamino)ethanol
124948-51-2

(E)-2-(benzylideneamino)ethanol

C23H27ClN2O4
917890-16-5

C23H27ClN2O4

Conditions
ConditionsYield
With 3 A molecular sieve In methanol at 20℃; Ugi reaction;63%
3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

3,5-Bis-(trifluoromethyl)aniline
328-74-5

3,5-Bis-(trifluoromethyl)aniline

N-(3,5-bis-trifluoromethyl-phenyl)-3-chloro-2-hydroxy-benzamide

N-(3,5-bis-trifluoromethyl-phenyl)-3-chloro-2-hydroxy-benzamide

Conditions
ConditionsYield
With pyridine; phosphorus trichloride In toluene Inert atmosphere; Reflux;59%
With phosphorus trichloride In toluene Inert atmosphere; Reflux;24%
With phosphorus trichloride In 5,5-dimethyl-1,3-cyclohexadiene for 5h; Reflux;
3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

propyl bromide
106-94-5

propyl bromide

3-chloro-2-propoxybenzoic acid propyl ester
894851-30-0

3-chloro-2-propoxybenzoic acid propyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 30℃; for 66h;51%
3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

ethyl 2-amino-2,3-dihydro-1H-indene-2-carboxylate
141104-65-6

ethyl 2-amino-2,3-dihydro-1H-indene-2-carboxylate

2-(3-chloro-2-hydroxy-benzoylamino)-indan-2-carboxylic acid ethyl ester
1092447-22-7

2-(3-chloro-2-hydroxy-benzoylamino)-indan-2-carboxylic acid ethyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃;49%
3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

methyl 3-((4-acetylpiperazin-1-yl)methyl)benzoate

methyl 3-((4-acetylpiperazin-1-yl)methyl)benzoate

methyl 3-((4-(8-chloro-4-oxochromen-2-yl)piperazin-1-yl)methyl)benzoate

methyl 3-((4-(8-chloro-4-oxochromen-2-yl)piperazin-1-yl)methyl)benzoate

Conditions
ConditionsYield
Stage #1: methyl 3-[(4-acetylpiperazin-1-yl)methyl]benzoate With trichlorophosphate In dichloromethane at 0 - 25℃; for 1h;
Stage #2: 3-Chloro-2-hydroxybenzoic acid In dichloromethane at 0 - 60℃; for 15h;
Stage #3: With sodium acetate In dichloromethane at 60℃; for 4h;
48.4%
C20H15N2PS2
89430-08-0

C20H15N2PS2

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

8-chloro-2-thioxo-2,3-dihydro-4H-1,3-benzoxazin-4-one

8-chloro-2-thioxo-2,3-dihydro-4H-1,3-benzoxazin-4-one

Conditions
ConditionsYield
In dichloromethane48%
tert-Octylamine
107-45-9

tert-Octylamine

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

3-chloro-2-hydroxy-N-(2,4,4-trimethylpentan-2-yl)benzamide

3-chloro-2-hydroxy-N-(2,4,4-trimethylpentan-2-yl)benzamide

Conditions
ConditionsYield
Stage #1: 3-Chloro-2-hydroxybenzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0℃; for 0.25h; Inert atmosphere;
Stage #2: tert-Octylamine In N,N-dimethyl-formamide at 0 - 20℃; for 16h;
43.08%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 16h; Inert atmosphere;36.58%
perfluoro-2-methylpent-2-ene
1584-03-8

perfluoro-2-methylpent-2-ene

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

4-(F-ethyl)-3-(F-methyl)-10-chloro-2H,6H-1,5-benzodioxocin-2,6-dione

4-(F-ethyl)-3-(F-methyl)-10-chloro-2H,6H-1,5-benzodioxocin-2,6-dione

Conditions
ConditionsYield
With triethylamine In acetonitrile for 5h; Ambient temperature;41%
3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

diazomethyl-trimethyl-silane
18107-18-1

diazomethyl-trimethyl-silane

methyl 3-chloro-5-nitrosalicylate
337520-41-9

methyl 3-chloro-5-nitrosalicylate

Conditions
ConditionsYield
With sulfuric acid; nitric acid In methanol; hexane; benzene39%
3-nitro-5-(trifluoromethyl)-phenylamine
401-94-5

3-nitro-5-(trifluoromethyl)-phenylamine

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

3-chloro-2-hydroxy-N-(3-nitro-5-(trifluoromethyl)phenyl)benzamide

3-chloro-2-hydroxy-N-(3-nitro-5-(trifluoromethyl)phenyl)benzamide

Conditions
ConditionsYield
With phosphorus trichloride In 5,5-dimethyl-1,3-cyclohexadiene for 5h; Reflux;39%
3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

3,5-dimethylaminoaniline
108-69-0

3,5-dimethylaminoaniline

3-chloro-N-(3,5-dimethylphenyl)-2-hydroxybenzamide

3-chloro-N-(3,5-dimethylphenyl)-2-hydroxybenzamide

Conditions
ConditionsYield
With phosphorus trichloride In toluene Inert atmosphere; Reflux;27%
1-[4-(3-aminophenyl)piperazin-1-yl]-2-(5-methyl-3-trifluoromethylpyrazol-1-yl)ethanone
1392267-89-8

1-[4-(3-aminophenyl)piperazin-1-yl]-2-(5-methyl-3-trifluoromethylpyrazol-1-yl)ethanone

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

3-chloro-2-hydroxy-N-(3-{4-[2-(5-methyl-3-trifluoromethylpyrazol-1-yl)acetyl]piperazin-1-yl}phenyl)benzamide
1392267-90-1

3-chloro-2-hydroxy-N-(3-{4-[2-(5-methyl-3-trifluoromethylpyrazol-1-yl)acetyl]piperazin-1-yl}phenyl)benzamide

Conditions
ConditionsYield
Stage #1: 3-Chloro-2-hydroxybenzoic acid With 1,1'-carbonyldiimidazole In acetonitrile at 60℃; for 2h;
Stage #2: 1-[4-(3-aminophenyl)piperazin-1-yl]-2-(5-methyl-3-trifluoromethylpyrazol-1-yl)ethanone With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 60℃;
26%
Stage #1: 3-Chloro-2-hydroxybenzoic acid With 1,1'-carbonyldiimidazole In acetonitrile at 60℃; for 2h;
Stage #2: 1-[4-(3-aminophenyl)piperazin-1-yl]-2-(5-methyl-3-trifluoromethylpyrazol-1-yl)ethanone With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 60℃;
2-amino-6-bromobenzothiazole
15864-32-1

2-amino-6-bromobenzothiazole

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

3-chloro-N-(6-bromo-1,3-benzothiazol-2-yl)-2-hydroxybenzamide

3-chloro-N-(6-bromo-1,3-benzothiazol-2-yl)-2-hydroxybenzamide

Conditions
ConditionsYield
Stage #1: 3-Chloro-2-hydroxybenzoic acid With phosphorus trichloride In chlorobenzene for 0.5h; Reflux;
Stage #2: 2-amino-6-bromobenzothiazole In chlorobenzene for 4h; Reflux;
26%
(1R)-5-chloroindan-1-amine

(1R)-5-chloroindan-1-amine

3-Chloro-2-hydroxybenzoic acid
1829-32-9

3-Chloro-2-hydroxybenzoic acid

C16H13Cl2NO2

C16H13Cl2NO2

Conditions
ConditionsYield
With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 12h;21%

3-Chlorosalicylic acid Chemical Properties

IUPAC Name: 3-chloro-2-hydroxybenzoic acid
Synonyms of 3-Chlorosalicylic acid (CAS NO,1829-32-9): 3EINECS 217-379-5 ; NSC 18854 ; Benzoic acid, 3-chloro-2-hydroxy- (9CI) ; Salicylic acid, 3-chloro- (8CI)
CAS NO: 1829-32-9
Molecular Formula: C7H5ClO3
Molecular Weight: 172.5658
Molecular Structure:

Melting Point: 184-186 °C
ProductCategories: Aromatics ; C7 ; Carbonyl Compounds ; Carboxylic Acids 
H bond acceptors: 3
H bond donors: 2
Freely Rotating Bonds: 2
Polar Surface Area: 35.53 Å2
Index of Refraction: 1.629
Molar Refractivity: 39.95 cm3
Molar Volume: 112.3 cm3
Surface Tension: 66 dyne/cm
Density of 3-Chlorosalicylic acid (CAS NO,1829-32-9): 1.536 g/cm3
Flash Point: 130.2 °C
Enthalpy of Vaporization: 56.1 kJ/mol
Boiling Point: 291.7 °C at 760 mmHg
Vapour Pressure: 0.000876 mmHg at 25°C

3-Chlorosalicylic acid Safety Profile

Hazard Codes: IrritantXi
Risk Statements: 36/37/38 
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36: Wear suitable protective clothing.
WGK Germany: 3

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