3-Hydroxypropanoic acid supplier

Name
3-HYDROXYPROPIONIC ACID
EINECS 207-974-8
CAS No. 503-66-2
Article Data105
CAS DataBase
Density 1.283 g/cm³
Solubility 270.1g/L(25 oC)
Melting Point 16.8°C (estimate)
Formula C₃H₆O₃
Boiling Point 279.7 °C at 760 mmHg
Molecular Weight 90.0788
Flash Point 137.2 °C
Transport Information
Appearance
Safety 26-36/37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Hydracrylicacid (6CI,7CI,8CI);2-Deoxyglyceric acid;Ethylenelactic acid;b-Hydroxypropionic acid;b-Lactic acid;
PSA 57.53000
LogP -0.54660

Synthetic route

: 535-17-1
2-acetoxypropionic acid

: 4272-12-2
3-acetoxypropionic acid

A: 849585-22-4
LACTIC ACID

B: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
With water; Amberlite IR 120 at 80℃; for 16h; Product distribution / selectivity;	A 100% B 100%
With water; hydrogenchloride at 100℃; for 16h; Product distribution / selectivity;
With water; toluene-4-sulfonic acid at 100℃; for 16h; Product distribution / selectivity;

...Expand

: 3-(hydroperoxy)propanoic acid

: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol under 2888.19 Torr; for 0.666667h;	100%
With palladium 10% on activated carbon; hydrogen In methanol under 2888.19 Torr; for 0.666667h; Baeyer-Villiger Ketone Oxidation;	100%

: 141-76-4
3-iodopropanoic acid

: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
With sodium hydroxide In water; hexan-1-ol at 80℃; for 2h; Solvent; Temperature; Reagent/catalyst;	99%
With rhodium on carbon; water; hydrogen iodide; hydrogen at 99.84℃; under 20686.5 Torr; for 1h; Autoclave;	69.4%
With water; silver(l) oxide
With water; silver(l) oxide man behandelt das Filtrat mit Schwefelwasserstoff, filtriert ab, neutralisiert das Filtrat mit Soda, verdampft und zieht das hydracrylsaure Natrium durch Alkohol aus und krystallisiert beim Erkalten aus;

: 109-78-4
3-Hydroxypropionitrile

: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
Stage #1: 3-Hydroxypropionitrile With sodium hydroxide In water for 8h; Reflux; Saturated solution; Stage #2: With hydrogenchloride In water	92.1%
With hydrogenchloride; water for 4h; Reagent/catalyst;	89%
With sodium hydroxide for 12h; Ambient temperature;	75%

: 57-57-8
β-Propiolactone

: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
With sodium hydroxide In methanol	77%
With barium dihydroxide; water
With water In 1,4-dioxane at 25℃; Kinetics; Further Variations:; Temperatures; Solvents;

: ammonium 3-hydroxypropionate

A: 79-06-1
2-propenamide

B: acrylic acid ammonium salt

C: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
With ammonia; Ti-0720 (Engelhard) catalyst In water at 200 - 250℃; for 37h; Product distribution / selectivity;	A n/a B 75% C n/a
titanium catalyst In water at 180℃; for 37h; Product distribution / selectivity;	A 1.5% B 65% C n/a
titanium catalyst In water at 180℃; for 37h; Product distribution / selectivity;	A 1.5% B 65% C n/a

...Expand

: 107-18-6
allyl alcohol

A: 79-10-7
acrylic acid

B: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
With oxygen; sodium hydroxide In water at 50℃; Reagent/catalyst; Sonication;	A 60.1% B 21.3%
With water; oxygen; sodium hydroxide at 50℃; under 2250.23 Torr; for 24h;	A 51.1% B 28.4%
With oxygen; sodium hydroxide In water at 50℃; under 2250.23 Torr; for 12h;

: 123-76-2
levulinic acid

A: 64-18-6
formic acid

B: 110-15-6
succinic acid

C: 431-47-0
trifluoroacetic acid-methyl ester

D: 64-19-7
acetic acid

E: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; trifluoroacetic acid In water at -78 - 90℃; for 1.66667h;	A 45% B 60% C 45% D 43% E 9%

...Expand

: 123-76-2
levulinic acid

: 76-05-1
trifluoroacetic acid

A: 64-18-6
formic acid

B: 110-15-6
succinic acid

C: 431-47-0
trifluoroacetic acid-methyl ester

D: 64-19-7
acetic acid

E: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In water at 90℃; for 1h;	A 45 %Spectr. B 60% C 45 %Spectr. D 43 %Spectr. E 9 %Spectr.

...Expand

: 109-99-9
tetrahydrofuran

: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In water at 90℃; under 7600.51 Torr; for 12h; Reagent/catalyst; Temperature; Solvent; Pressure; Inert atmosphere;	58%

: 79-10-7
acrylic acid

: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
With water at 230℃; for 2h; sealed tube;	56%
With water at 200℃; reaction order of hydration, kinetic curves; other temperatures;
With sulfuric acid at 101.5℃; Kinetics; var. ratio of reactants, var. temperature;
With 4-methoxy-phenol In water at 80℃; Temperature; Flow reactor;

: 123-76-2
levulinic acid

: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; potassium hydroxide In water at 0 - 115℃; for 1h; Baeyer-Villiger Ketone Oxidation;	45%

: 107-18-6
allyl alcohol

A: 473-81-4
glyceric acid

B: 79-10-7
acrylic acid

C: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
With oxygen; sodium hydroxide In water at 50℃; Reagent/catalyst; Sonication;	A 6.9% B 30.1% C 7.2%

...Expand

: 107-18-6
allyl alcohol

A: 473-81-4
glyceric acid

B: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
With cerium(IV) oxide Reagent/catalyst;	A 19% B 23.2%
With nano gold salt supported on cerium oxide	A 10.7% B 9.4%

: 107-19-7
propargyl alcohol

A: 74-85-1
ethene

B: 116-09-6
hydroxy-2-propanone

C: 79-10-7
acrylic acid

D: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
With water; ruthenium tetrasulphthalocyanine at 80℃; for 24h; Product distribution; Further Variations:; Catalysts; anti-Markovnikov hydration;	A n/a B 10% C 22% D 10%

...Expand

: 107-18-6
allyl alcohol

: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
With nano gold salt	21.1%
With iron(III) oxide	14.4%

: 75-21-8
oxirane

: 74-90-8
hydrogen cyanide

A: 79-10-7
acrylic acid

B: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
at 50 - 60℃; Behandeln des erhaltenen Nitrils mit rauchender Salzsaeure;

...Expand

: 590-92-1
3-Bromopropionic acid

: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
With water quantitativer Verlauf der Bildung;
With sodium hydroxide quantitativer Verlauf der Bildung;

: 71-23-8
propan-1-ol

A: 849585-22-4
LACTIC ACID

B: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
With Fehling's solution at 240℃;
at 240℃; bei loegeren Erhitzen mit Fehlingscher Loesung;
at 240℃; bei 200-stuendigem Erhitzen mit Fehlingscher Loesung;

: 141-76-4
3-iodopropanoic acid

A: 79-10-7
acrylic acid

B: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
With water
With calcium hydroxide

: 855955-85-0
1-hydroxy-5-methyl-hept-4-en-3-one

: 67-66-3
chloroform

A: 78-93-3
butanone

B: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
bei der Ozonspaltung; 7-hydroxy-3-methyl-hepten-(3)-one-(5);

...Expand

: 79-21-0
peracetic acid

: 105-50-0
diethyl 1,3-acetonedicarboxylate

A: 144-62-7
oxalic acid

B: 503-66-2
3-hydroxypropionic acid

...Expand

: 151-50-8
potassium cyanide

: 107-07-3
2-chloro-ethanol

A: 849585-22-4
LACTIC ACID

B: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
Verseifung des gebildeten Nitrils mit Natronlauge;
Verseifung des gebildeten Nitrils mit rauchender Salzsaeure;

...Expand

: 4244-83-1
β-carboxyethyl-N-nitroamine

: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
With sulfuric acid In water at 25℃; Rate constant;
With sulfuric acid at 25 - 85℃; Kinetics; Mechanism; Thermodynamic data; ΔH(excit.), -ΔS(excit.);

: 86641-76-1
3,12-bis(3'-bromo-1'-oxopropyl)-3,12-diaza-6,9-diazoniadispiro<5.2.5.2>hexadecane dichloride

A: 590-92-1
3-Bromopropionic acid

B: 107-94-8
chloropropionic acid

C: 121051-82-9
3,12-bis(3'-chloro-1'-oxopropyl)-3,12-diaza-6,9-diazoniadispiro<5.2.5.2>hexadecane dibromide

D: 95461-34-0
3,12-Bisacrylyl-3,12-diaza-6,9-diazoniadispiro<5,2,5,2>hexadecane dichloride

E: 122842-21-1
3,12-bis(3'-hydroxy-1'-oxopropyl)-3,12-diaza-6,9-diazoniadispiro<5.2.5.2>hexadecane dichloride

F: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
In water at 70℃; for 5h; Product distribution; Kinetics; Rate constant; various time; other temperature;

...Expand

: 802294-64-0
propionic acid

A: 64-18-6
formic acid

B: 79-14-1
glycolic Acid

C: 849585-22-4
LACTIC ACID

D: 141-82-2
malonic acid

E: 64-19-7
acetic acid

F: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In water at 20℃; Product distribution; Mechanism; Irradiation; effect of H2O2/proponic acid ratio, iraadiation time;

...Expand

: 802294-64-0
propionic acid

A: 849585-22-4
LACTIC ACID

B: 141-82-2
malonic acid

C: 64-19-7
acetic acid

D: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In water at 20℃; Irradiation; Further byproducts given;

...Expand

: C9H10N2O6S

A: 31867-78-4
3-benzenesulfonylamino-propionic acid

B: 98-11-3
benzenesulfonic acid

C: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
With sulfuric acid In water at 25℃; Rate constant;

...Expand

: 79-10-7
acrylic acid

A: 849585-22-4
LACTIC ACID

B: 473-81-4
glyceric acid

C: 802294-64-0
propionic acid

D: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In water at 30℃; Product distribution; Irradiation; 40/90 mA, 750 V, photooxidation by glow discharge electrolysis in various cells, with various reaction times and currents, at various temperatures with or without irradiation;
With dihydrogen peroxide In water Product distribution; Quantum yield; Irradiation; var. amount of absorbed energy;

...Expand

: 503-66-2
3-hydroxypropionic acid

: 79-10-7
acrylic acid

Conditions

Conditions	Yield
titanium catalyst 16-30 mesh at 180 - 190℃; for 45h; Product distribution / selectivity;	100%
With 4-methoxy-phenol; silica gel at 250℃; Gas phase;	97%
sulfuric acid at 160℃; Product distribution / selectivity;	96.2%

: 77377-52-7
N-methyl-N-tert-butyldimethylsilyl-1,1,1-trifluoroacetamide

: 503-66-2
3-hydroxypropionic acid

: 82112-30-9
C15H34O3Si2

Conditions

Conditions	Yield
With tert-butyldimethylsilyl chloride In acetonitrile for 0.0833333h; Ambient temperature; other silylating agent;	100%

: 67-56-1
methanol

: 503-66-2
3-hydroxypropionic acid

: 292638-85-8
acrylic acid methyl ester

Conditions

Conditions	Yield
With 4-methoxy-phenol; EM-1500 zeolite at 150℃; Product distribution / selectivity; Gas phase;	97.4%
With sulfuric acid; copper at 155 - 165℃;
With phosphoric acid; copper at 135 - 145℃;

: 503-66-2
3-hydroxypropionic acid

: 141-82-2
malonic acid

Conditions

Conditions	Yield
With sodium hydroxide In water	97%
With sodium hydroxide elektrochemische Oxydation, am besten an einer Nickelanode;

: 100-46-9
benzylamine

: 503-66-2
3-hydroxypropionic acid

: 19340-82-0
3-hydroxy-N-(phenylmethyl)propanamide

Conditions

Conditions	Yield
With 4-(2-(1,3-dioxa-3a1,8,10-triaza-2,3a,14b-triboradibenzo[fg,op]tetracen-2-yl)phenyl)benzo[c]pyrimido[4,5-e][1,2]azaborinin-6(5H)-ol In fluorobenzene at 85℃; for 8h; Molecular sieve;	94%

: 62-53-3
aniline

: 503-66-2
3-hydroxypropionic acid

: 66223-76-5
N-phenyl hydroxy-3 propanamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 14h;	93%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 503-66-2
3-hydroxypropionic acid

: 120821-20-7
3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propanoic acid

Conditions

Conditions	Yield
With 1H-imidazole In dichloromethane	92%

: 1630-83-7
4-bromo-β-estradiol

: 503-66-2
3-hydroxypropionic acid

: C21H28O5

Conditions

Conditions	Yield
In methanol at 60℃; for 20h;	92%

: 503-66-2
3-hydroxypropionic acid

A: 71-23-8
propan-1-ol

B: 110-63-4
Butane-1,4-diol

Conditions

Conditions	Yield
With hydrogen In water at 100℃; under 37503.8 Torr; for 30h; Pressure; Reagent/catalyst; Autoclave;	A 10% B 85%

: 134532-14-2
N-δ-Boc-3-hydroxy-DL-ornithine tert-butyl ester

: 503-66-2
3-hydroxypropionic acid

: 134532-15-3
5-tert-Butoxycarbonylamino-3-hydroxy-2-(3-hydroxy-propionylamino)-pentanoic acid tert-butyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 16h;	82%

: 73995-50-3
H-Orn(Z)-OBzl

: 503-66-2
3-hydroxypropionic acid

: 134532-11-9
(S)-5-Benzyloxycarbonylamino-2-(3-hydroxy-propionylamino)-pentanoic acid benzyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 16h;	81%

: 503-66-2
3-hydroxypropionic acid

A: 71-23-8
propan-1-ol

B: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With ruthenium-carbon composite; hydrogen In water at 119.84℃; under 7500.75 - 60006 Torr; for 2h; Catalytic behavior; Autoclave; Sealed tube;	A 18% B 79%

: C11H14O4

: 503-66-2
3-hydroxypropionic acid

: C17H22O8

Conditions

Conditions	Yield
With pyridinium p-toluenesulfonate In N,N-dimethyl-formamide at 70℃; for 5h;	75%

: (R)-N-(4-(tert-butyl)-3-fluorophenyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxamide

: 503-66-2
3-hydroxypropionic acid

: (1R)-N-(4-tert-butyl-3-fluorophenyl)-2-(3-hydroxypropanoyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In water; N,N-dimethyl-formamide at 20℃; for 15h;	74.3%

: 67-56-1
methanol

: 503-66-2
3-hydroxypropionic acid

: 6149-41-3
methyl ester (3-hydroxy) propionic acid

Conditions

Conditions	Yield
With sodium at 50℃;	72.1%
With copper(II) sulfate
sulfuric acid at 20℃; for 1.5 - 22h; Product distribution / selectivity;	75 - 95 %Chromat.

: 4-[(trans-4-aminocyclohexyl)oxy]-5-bromo-1-methylpyridin-2(1H)-one hydrochloride

: 503-66-2
3-hydroxypropionic acid

: N-{trans-4-[(5-bromo-1-methyl-2-oxo-1,2-dihydropyridin-4-yl)oxy]cyclohexyl}-3-hydroxypropanamide

Conditions

Conditions	Yield
With triethylamine; N-ethyl-N,N-diisopropylamine; HATU In tetrahydrofuran at 20℃; for 2h; Inert atmosphere;	68%

: 64-17-5
ethanol

: 503-66-2
3-hydroxypropionic acid

: 623-72-3
ethyl 3-hydroxypropanoate

Conditions

Conditions	Yield
With sulfuric acid at 78 - 80℃; under 760.051 Torr; for 10h; Time;	67.24%
With copper(II) sulfate
amberlyst-15 at 20℃; for 19h; Product distribution / selectivity;	17 - 68 %Chromat.
Nafion NR-50 at 20℃; for 21h; Product distribution / selectivity;	71 %Chromat.

: 921935-07-1
C20H14ClN3O4

: 503-66-2
3-hydroxypropionic acid

: 921935-08-2
C23H19N3O7

Conditions

Conditions	Yield
In tetrahydrofuran; N,N-dimethyl-formamide for 1h;	61%

: 60547-97-9
4-amino-6,7-dimethoxy-2-piperazin-1-ylquinazoline

: 503-66-2
3-hydroxypropionic acid

: 1-(4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)-3-hydroxypropan-1-one

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; ethyl cyanoglyoxylate-2-oxime In N,N-dimethyl-formamide at 20℃;	61%

: 503-66-2
3-hydroxypropionic acid

: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With hydrogen; molybdenum(IV) oxide In water at 150℃; under 78334.3 Torr; for 3h; Product distribution / selectivity;	60%
With hydrogen; molybdenum In ISOPAR K; water at 150℃; under 78334.3 Torr; for 3h; Product distribution / selectivity;	57%
With hydrogen In water at 100℃; under 78334.3 Torr; for 16h; Product distribution / selectivity;	47%

3-Hydroxypropanoic acid Chemical Properties

Molecular structure of Propanoic acid,3-hydroxy- (CAS NO.503-66-2) is:

Product Name: Propanoic acid,3-hydroxy-
CAS Registry Number: 503-66-2
IUPAC Name: 3-Hydroxypropanoic acid
Molecular Weight: 90.07794 [g/mol]
Molecular Formula: C₃H₆O₃
XLogP3-AA: -1
H-Bond Donor: 2
H-Bond Acceptor: 3
EINECS: 207-974-8
Surface Tension: 53.7 dyne/cm
Density: 1.283 g/cm³
Flash Point: 137.2 °C
Enthalpy of Vaporization: 60.18 kJ/mol
Boiling Point: 279.7 °C at 760 mmHg
Vapour Pressure: 0.000476 mmHg at 25°C
Product Categories: Aliphatics;Carboxylic Acids;omega-Functional Alkanols, Carboxylic Acids, Amines & Halides;omega-Hydroxycarboxylic Acids;Carboxylic Acids

3-Hydroxypropanoic acid Safety Profile

Safty information about Propanoic acid,3-hydroxy- (CAS NO.503-66-2) is:
Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.

3-Hydroxypropanoic acid Specification

Propanoic acid,3-hydroxy- , its cas register number is 503-66-2. It also can be called 3-Hydroxypropanoic acid ; Ethylene lactic acid ; Glyceric acid, 2-deoxy- ; Hydracrylic acid ; beta-Hydroxypropionic acid ; beta-Lactic acid .

Product Name

3-HYDROXYPROPIONIC ACID

Synthetic route

3-Hydroxypropanoic acid Chemical Properties

3-Hydroxypropanoic acid Safety Profile

3-Hydroxypropanoic acid Specification

Related Products

Hot Products