3-Methoxypropionitrile supplier

Name
3-Methoxypropionitrile
EINECS 203-790-7
CAS No. 110-67-8
Article Data38
CAS DataBase
Density 0.902 g/cm³
Solubility 335 g/L (20 °C) in water
Melting Point -62.9 °C
Formula C₄H₇NO
Boiling Point 163 °C at 760 mmHg
Molecular Weight 85.1057
Flash Point 61.1 °C
Transport Information
Appearance colourless liquid
Safety 26-36-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms NSC61486;b-Methoxypropionitrile;3-Methoxy propionitrile;Propionitrile,3-methoxy- (6CI,7CI,8CI);1-Cyano-2-methoxyethane;1-Methoxy-2-cyanoethane;2-Cyanoethyl methyl ether;Methyl b-cyanoethyl ether;NSC 4090;
PSA 33.02000
LogP 0.54648

Synthetic route

: 67-56-1
methanol

: 107-13-1
acrylonitrile

: 110-67-8
3-Methoxypropionitrile

Conditions

Conditions	Yield
With [μN,κP,κC,κN-{2-(i-Pr2PO),6-(CH2NBn)-(C6H3)}Ni]2 In benzene at 50℃; for 1h;	100%
With 1-Methylpyrrolidine; barium(II) hydroxide In methanol at 25℃; for 7h;	98%
	86%

: 124-41-4
sodium methylate

: 107-13-1
acrylonitrile

: 110-67-8
3-Methoxypropionitrile

Conditions

Conditions	Yield
In methanol; water at 45℃; for 3h; Temperature;	93%

: 67-56-1
methanol

: 50434-02-1
2-cyanoethyl nitrate

: 110-67-8
3-Methoxypropionitrile

Conditions

Conditions	Yield
With sodium hydroxide In water at 9 - 11℃; for 1h; Etherification;	83%

: 67-56-1
methanol

: 107-13-1
acrylonitrile

A: 151-18-8
2-cyanoethylamine

B: 110-67-8
3-Methoxypropionitrile

C: 107-12-0
propiononitrile

Conditions

Conditions	Yield
With ammonia; hydrogen; chromium; cobalt; iron; nickel at 100℃; under 60004.8 Torr;	A 65% B 20% C 15%

...Expand

: 186581-53-3, 908094-01-9
diazomethane

: 109-78-4
3-Hydroxypropionitrile

: 110-67-8
3-Methoxypropionitrile

: 15438-67-2
(3-methoxypropyl)amide

: 110-67-8
3-Methoxypropionitrile

Conditions

Conditions	Yield
With phosphorus pentoxide

: 67-56-1
methanol

: 124-41-4
sodium methylate

: 107-13-1
acrylonitrile

: 110-67-8
3-Methoxypropionitrile

Conditions

Conditions	Yield
at 20℃; Rate constant;
at 20℃; Kinetics;

...Expand

: 107-31-3
Methyl formate

: 109-78-4
3-Hydroxypropionitrile

A: 110-67-8
3-Methoxypropionitrile

B: 2141-62-0
3-(ethoxy)propionitrile

Conditions

Conditions	Yield
With diethyl ether; sodium ethanolate

...Expand

: 109-78-4
3-Hydroxypropionitrile

: 616-38-6
carbonic acid dimethyl ester

: 110-67-8
3-Methoxypropionitrile

Conditions

Conditions	Yield
With sodium methylate; benzene

: 96-34-4
methyl chloroacetate

: 107-13-1
acrylonitrile

: 110-67-8
3-Methoxypropionitrile

Conditions

Conditions	Yield
With sodium amalgam; water

: 67-56-1
methanol

: 107-13-1
acrylonitrile

A: 110-67-8
3-Methoxypropionitrile

B: 57597-62-3
3,3-dimethoxypropionitrile

Conditions

Conditions	Yield
With carbon dioxide; oxygen; copper dichloride; palladium dichloride at 57℃; under 97507.8 Torr; for 12h;	A 10.7 % Chromat. B 87.5 % Chromat.

...Expand

: 110-67-8
3-Methoxypropionitrile

: β-methoxypropionamidine

Conditions

Conditions	Yield
Stage #1: With trimethylaluminum; ammonium chloride In toluene at 20℃; for 1.5h; Stage #2: 3-Methoxypropionitrile In toluene at 85℃; for 9h;	98%

: 110-67-8
3-Methoxypropionitrile

: 137-07-5
2-amino-benzenethiol

: 1427180-60-6
2-(2-methoxyethyl)benzo[d]thiazole

Conditions

Conditions	Yield
With copper diacetate; triethylamine In ethanol at 70℃; for 6h;	97%

: 110-67-8
3-Methoxypropionitrile

: 5332-73-0
3-methoxypropylamine

Conditions

Conditions	Yield
With hydrogen at 60 - 98℃; under 1500.15 - 22502.3 Torr; for 6h; Temperature;	95%
With hydrogenchloride; platinum(IV) oxide; hydrogen In ethanol under 2280 Torr; for 4h;	30%
With ammonia; hydrogen; Rh catalyst under 51485.6 Torr;

: 110-67-8
3-Methoxypropionitrile

: 77113-75-8
3,5-bis(hydroxymethyl)benzaldehyde

: 77113-64-5
(Z)-3-(3,5-Bis-hydroxymethyl-phenyl)-2-methoxymethyl-acrylonitrile

Conditions

Conditions	Yield
With sodium methylate In methanol for 7h; Heating;	95%

: 67-56-1
methanol

: 110-67-8
3-Methoxypropionitrile

: 61737-87-9
methyl 3-(methoxy)propionimidate hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether at 0℃; for 72h;	92%
With hydrogenchloride In cyclopentyl methyl ether Pinner amidine synthesis; Cooling with ice;	91%
With hydrogenchloride In diethyl ether at 10℃; for 72h;	88%
With hydrogenchloride In diethyl ether at 0℃; for 24h;	87%

: 110-67-8
3-Methoxypropionitrile

: 260783-56-0
Cp*IrCl(η3-CH2CHCHPh)

: 2923-28-6
silver trifluoromethanesulfonate

: 299410-01-8
[(C5(CH3)5)Ir(η3-CH2CHCHC6H5)(NCCH2CH2OCH3)](OSO2CF3)

Conditions

Conditions	Yield
In chloroform byproducts: AgCl; under N2; AgOSO2CF3 and CH3OCH2CH2CN were added to a CHCl3 soln. of thecomplex, the mixt. was stirred at 25°C for 1 h; the mixt. was filtered and distd. under vac., the solid was recrystd. in cold (CHCl3/(C2H5)2O); elem. anal.;	91%

...Expand

: 76-84-6
triphenylmethyl alcohol

: 110-67-8
3-Methoxypropionitrile

: 1412436-23-7
C23H23NO2

Conditions

Conditions	Yield
With silica-bonded N-propylsulphamic acid In neat (no solvent) at 80℃; for 2.83333h; Ritter Amidation; Green chemistry;	91%

: 91-01-0
1,1-Diphenylmethanol

: 110-67-8
3-Methoxypropionitrile

: 1412436-26-0
C17H19NO2

Conditions

Conditions	Yield
With silica-bonded N-propylsulphamic acid In neat (no solvent) at 80℃; for 1h; Ritter Amidation; Green chemistry;	91%

: 50-00-0
formaldehyd

: 110-67-8
3-Methoxypropionitrile

: 3001-75-0
1,3,5-tris-(3-methoxy-propionyl)-[1,3,5]triazinane

Conditions

Conditions	Yield
Amberlyst 15 resin In chlorobenzene at 80℃; for 6h;	90%

: 688-61-9, 53588-88-8, 90721-85-0, 151452-33-4, 151452-35-6
Triallylborane

: 110-67-8
3-Methoxypropionitrile

: 315248-93-2
4-(2-methoxyethyl)-1,6-heptadien-4-amine

Conditions

Conditions	Yield
Stage #1: Triallylborane; 3-Methoxypropionitrile at 110℃; for 1h; Neat (no solvent); Stage #2: With water; sodium hydroxide In methanol at 110 - 120℃;	89%
Stage #1: Triallylborane; 3-Methoxypropionitrile at -30 - -20℃; Inert atmosphere; Stage #2: at 100 - 140℃; Further stages;	89%

: 110-67-8
3-Methoxypropionitrile

: 4-acetoxy-1-acetyl-4-phenylazo-1,2,3,4-tetrahydroquinoline

: 6-acetyl-2-(2-methoxyethyl)-1-phenyl-5,6-dihydro-4H-benzo[b][1,2,4]triazolo[1,5-d][1,4]diazepinium chloride

Conditions

Conditions	Yield
Stage #1: 3-Methoxypropionitrile; 4-acetoxy-1-acetyl-4-phenylazo-1,2,3,4-tetrahydroquinoline With aluminum (III) chloride In dichloromethane at -40 - 20℃; for 1.5h; Inert atmosphere; Stage #2: With hydrogenchloride In water; acetonitrile	88%

: 110-67-8
3-Methoxypropionitrile

: C37H70N2O12

: C41H75N3O13

Conditions

Conditions	Yield
Stage #1: C37H70N2O12 With sodium sulfate In dichloromethane for 0.5h; Stage #2: 3-Methoxypropionitrile In dichloromethane at 0 - 5℃; for 2h; Inert atmosphere;	88%

: 110-67-8
3-Methoxypropionitrile

: 124-41-4
sodium methylate

: 34450-83-4
sodium 2-cyano-3-methoxyprop-1-en-1-olate

Conditions

Conditions	Yield
In ethyl methyl ether; toluene at 48 - 50℃; for 28h; Temperature; Solvent;	87%

: 19392-93-9, 32490-70-3
trans-hydridochloro-di-{1,2-bis(diphenylphosphino)ethane}iron(II)

: 110-67-8
3-Methoxypropionitrile

: 252659-26-0
trans-[FeH(3-methoxypropionitrile)(dppe)2]Cl

Conditions

Conditions	Yield
In further solvent(s) Ar-atmosphere; stirring in MeOCH2CH2CN for 2 h; solvent removal (vac.), washing (Et2O); elem. anal.;	86.2%

methanolic potassium hydroxide: methanolic potassium hydroxide

: 110-67-8
3-Methoxypropionitrile

: 120-14-9
3,4-dimethoxy-benzaldehyde

: α-(3,4-dimethoxy-benzal)-β-methoxy-propionitrile

Conditions

Conditions	Yield
In methanol; water	85%

...Expand

: 19392-93-9, 32490-70-3
trans-hydridochloro-di-{1,2-bis(diphenylphosphino)ethane}iron(II)

: 110-67-8
3-Methoxypropionitrile

: 143-66-8
sodium tetraphenyl borate

: 252659-28-2
trans-[FeH(3-methoxypropionitrile)(dppe)2][BPh4]

Conditions

Conditions	Yield
In further solvent(s) byproducts: NaCl; Ar-atmosphere; stirring Fe-complex in MeOCH2CH2CN for 4 h, addn. of NaBPh4, stirring for 1 h; filtration, solvent removal (vac.), extn. into CH2Cl2, solvent removal, washing (THF), recrystn. (CH2Cl2/hexane); elem. anal.;	85%

...Expand

: 38117-54-3
cyclopentadienyl iron(II) dicarbonyl dimer

: 1282-37-7
ferrocenium(III) tetrafluoroborate

: 110-67-8
3-Methoxypropionitrile

: {(C5H5)Fe(CO)2(CH3OC2H4CN)}(1+)*{BF4}(1-)={(C5H5)Fe(CO)2(CH3OC2H4CN)}{BF4}

Conditions

Conditions	Yield
In dichloromethane byproducts: (C5H5)2Fe; addn. of soln. of excess nitrile in CH2Cl2 to soln. of (C5H5Fe(CO)2)2 and ferricenium salt in CH2Cl2 (under N2, room temp.), stirred (0.2-1.5 h, room temp., color change from deep blue to dark orange-brown); soln. filtered, pptn. by addn. of ether, ppt. filtered off, washed with ether and pentane, recrystn. from CH2Cl2/ether (1/1 to 1/3);	82%

...Expand

: 110-67-8
3-Methoxypropionitrile

: 1295561-35-1
N-methyl-p-toluenesulfonyl-N-(hex-1-yn-1-yl)amine

: N,N'-(3,5-dibutyl-6-(2-methoxyethyl)pyridine-2,4-diyl)bis(N,4-dimethylbenzenesulfonamide)

Conditions

Conditions	Yield
With bis(trifluoromethanesulfonyl)amide In 1,2-dichloro-ethane at 20℃; for 12h; Inert atmosphere; regioselective reaction;	82%

: 110-67-8
3-Methoxypropionitrile

: 104-85-8
para-methylbenzonitrile

: C12H14N2O

Conditions

Conditions	Yield
With potassium tert-butylate In tert-butyl alcohol at 20℃; for 3h; Thorpe reaction; sonication;	78%

: 110-67-8
3-Methoxypropionitrile

: 28746-20-5
3-(methoxymethyl)benzaldehyde

: 77113-69-0
(Z)-2-Methoxymethyl-3-(3-methoxymethyl-phenyl)-acrylonitrile

Conditions

Conditions	Yield
With sodium methylate In methanol for 7h; Heating;	77.9%

: 110-67-8
3-Methoxypropionitrile

: 105-36-2
ethyl bromoacetate

: 104629-86-9
5-methoxy-3-oxopentanic acid ethyl ester

Conditions

Conditions	Yield
With hydrogenchloride; Zn/Cu In tetrahydrofuran	77.5%
With copper; zinc In tetrahydrofuran for 0.5h; Heating;	75%

: 110-67-8
3-Methoxypropionitrile

: 30225-99-1
2,3,4,5-Tetramethoxyphenol

: β-methoxy-α-(2,3,4,5,6-pentamethoxybenzylidene)propionitrile

Conditions

Conditions	Yield
With sodium methylate In methanol for 15h; Heating;	76%

: 110-67-8
3-Methoxypropionitrile

: 38187-09-6
2-amino-3,4-bis(aminocarbonyl)-5-(methylthio)pyrrole

: 122283-86-7
2-[(3-Methoxy-propionimidoyl)-amino]-5-methylsulfanyl-1H-pyrrole-3,4-dicarboxylic acid diamide

Conditions

Conditions	Yield
With hydrogenchloride for 2h; Ambient temperature;	76%

: 110-67-8
3-Methoxypropionitrile

: 96-32-2
bromoacetic acid methyl ester

: 62462-05-9
methyl 5-methoxy-3-oxopentanoate

Conditions

Conditions	Yield
With copper; zinc In tetrahydrofuran for 0.5h; Heating;	76%

: 64-17-5
ethanol

: 110-67-8
3-Methoxypropionitrile

: 20914-90-3
3-methoxypropionimidic acid ethyl ester hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether for 24h; cooling;	76%
With hydrogenchloride at 0 - 20℃; for 12h; Inert atmosphere;	63%
With hydrogenchloride In toluene at 0 - 20℃;
With hydrogenchloride at 20℃;

: 110-67-8
3-Methoxypropionitrile

: 1333483-14-9
N-methyll-N-(phenylethylnyl)methanesulfonamide

: C18H25N3O4S

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid In dichloromethane at -40℃; Inert atmosphere; Molecular sieve; Green chemistry;	76%

: 623-03-0
4-Cyanochlorobenzene

: 110-67-8
3-Methoxypropionitrile

: C11H11ClN2O

Conditions

Conditions	Yield
With potassium tert-butylate In tert-butyl alcohol at 20℃; for 3h; Thorpe reaction; sonication;	75%

3-Methoxypropionitrile Chemical Properties

Product Name: 3-Methoxypropionitrile (CAS NO.110-67-8)

Molecular formula: C₄H₇NO
Molecular Weight: 85.1
EINECS: 203-790-7
Boiling Point: 163 °C at 760 mmHg
Flash Point: 61.1 °C
Index of Refraction: 1.387
Molar Refractivity: 22.23 cm³
Molar Volume: 94.3 cm³
Surface Tension: 29.2 dyne/cm
Density: 0.902 g/cm³
Enthalpy of Vaporization: 39.95 kJ/mol
Vapour Pressure: 2.11 mmHg at 25°C
Refractive index: n20/D 1.403(lit.)
Water Solubility: 335 g/L (20 °C)
BRN: 1739284
IUPAC Name: 3-methoxypropanenitrile
Product Categories: C1 to C5;Cyanides/Nitriles; Nitrogen Compounds
Synonyms: 2-Cyanoethyl methyl ether ; 1-Cyano-2-methoxyethane ; 2-cyanoethylmethylether ; 3-methoxy-propionitril ; 3-Methoxypropylnitrile ; 3-methoxy-propanenitril ; 3-Methoxypropanenitrile ; 3-Methoxypropannitril

3-Methoxypropionitrile Uses

3-Methoxypropionitrile (CAS NO.110-67-8) is used in organic synthesis, but also a good solvent for plastic polymers.

3-Methoxypropionitrile Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	2900mg/kg (2900mg/kg)	Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. Vol. 19, Pg. 225, 1969.
mouse	LD50	oral	3200mg/kg (3200mg/kg)	"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 916, 1986.
rabbit	LD50	skin	> 10mL/kg (10mL/kg)	American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.
rat	LD50	oral	4390mg/kg (4390mg/kg)	American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.

3-Methoxypropionitrile Consensus Reports

Reported in EPA TSCA Inventory. Cyanide and its compounds are on the Community Right-To-Know List.

3-Methoxypropionitrile Safety Profile

Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. Flammable liquid when exposed to heat, flame, or oxidizers. Reacts with water, steam, or acids to produce toxic and flammable vapors. To fight fire, use CO₂, dry chemical. When heated to decomposition it emits highly toxic fumes of CN⁻. See also NITRILES.
Safety Information of 3-Methoxypropionitrile (CAS NO.110-67-8):
The Hazard Codes: Xi
HazardClass: 3.2
The Risk Statements information:
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements information:
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37/39: Wear suitable gloves and eye/face protection
RIDADR: 3276
WGK Germany: 2
RTECS: TZ4870000
PackingGroup: III
HS Code: 29269095

Product Name

3-Methoxypropionitrile

Synthetic route

3-Methoxypropionitrile Chemical Properties

3-Methoxypropionitrile Uses

3-Methoxypropionitrile Toxicity Data With Reference

3-Methoxypropionitrile Consensus Reports

3-Methoxypropionitrile Safety Profile

Related Products

Hot Products