4'-Methoxyacetophenone supplier

Name
4'-Methoxyacetophenone
EINECS 202-815-9
CAS No. 100-06-1
Article Data1225
CAS DataBase
Density 1.035 g/cm³
Solubility Insoluble in water
Melting Point 36-38 °C(lit.)
Formula C₉H₁₀O₂
Boiling Point 256.4 °C at 760 mmHg
Molecular Weight 150.177
Flash Point 113.2 °C
Transport Information
Appearance White crystals or crystalline powder
Safety 37-37/39-26-36
Risk Codes 22-38-36/38-20/21/22
Molecular Structure
Hazard Symbols Xn
Synonyms Acetophenone,4'-methoxy- (8CI);Benzophenone, p-methoxy- (3CI);1-(4-Methoxyphenyl)ethanone;1-Acetyl-4-methoxybenzene;4-Acetylanisole;4-Methoxyphenyl methyl ketone;Acetoanisole;Linarodin;Methyl 4-methoxyphenyl ketone;Methyl p-methoxyphenyl ketone;Novatone;Vananote;p-Acetylanisole;p-Anisyl methyl ketone;p-Methoxy(acetyl)benzene;p-Methoxyacetophenone;p-Methoxyphenyl methyl ketone;para-Methoxyacetophenone;
PSA 26.30000
LogP 1.89780

Synthetic route

: 637-69-4
4-Methoxystyrene

: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; C21H19N5Pd(2+)*2BF4(1-) In decane; acetonitrile at 45℃; for 4h; Wacker Oxidation;	100%
With water; oxygen In methanol; dimethyl sulfoxide at 80℃; under 1520.1 Torr; for 20h; Wacker Oxidation; Autoclave;	99%
With palladium diacetate; 9-tert-butyl-10-methylanthracene ozonide In acetonitrile for 72h; Ambient temperature;	93%

: 3319-15-1
rac-1-(4-methoxyphenyl)-ethanol

: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With 2.9-dimethyl-1,10-phenanthroline; oxygen; sodium hydrogencarbonate; gold(I) chloride In water at 100℃; under 38002.6 Torr; for 24h;	100%
With Cp*Ir(6,6'-dionato-2,2'-bipyridine)(H2O) In pentane for 5h; Reflux;	100%
With diisopropoxyaluminium trifluoroacetate; 4-nitrobenzaldehdye In benzene for 0.25h; Ambient temperature;	99%

: 108-24-7
acetic anhydride

: 100-66-3
methoxybenzene

: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With polystyrene-bound tetrafluorophenylbis(triflyl)methane In nitromethane at 50℃; for 2h; Friedel-Crafts acylation;	100%
With lithium perchlorate at 60℃; for 1h;	100%
With Sulfate; zirconium(IV) oxide at 110℃;	100%

: 64-19-7
acetic acid

: 100-66-3
methoxybenzene

: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
Stage #1: acetic acid; methoxybenzene With trifluoroacetic anhydride In dichloromethane at 20℃; for 0.25h; Stage #2: With trifluorormethanesulfonic acid In dichloromethane at 20℃; for 1h;	100%
With methanesulfonic acid; pyrographite at 80℃; for 0.333333h; Friedel-Crafts acylation;	98%
With aluminum oxide; trifluoroacetic anhydride for 0.166667h; Ambient temperature;	96%

: 128881-90-3
1-(1,1-Bis-ethylsulfanyl-ethyl)-4-methoxy-benzene

: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With gallium(III) trichloride In dichloromethane; water for 0.25h; Ambient temperature;	100%

: 100-66-3
methoxybenzene

: 79562-11-1
N,N-diacetyl-p-nitrophenylsulphenamide

A: 22865-50-5
4-(4-methoxyphenylsulfanyl)nitrobenzene

B: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With trifluoroacetic acid at 190 - 200℃;	A 100% B 21%

...Expand

: 768-60-5
4-methoxyphenylacetylen

: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With gold(III) tribromide; water at 200℃; for 0.333333h; microwave irradiation;	100%
With Au nanoparticles covalently bonded to HS/SO3H functionalized periodic mesoporous organosilica (Et) at 70℃; for 1.5h; neat (no solvent);	100%
With hydrogenchloride; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane at 48℃; for 20h; Solvent; Schlenk technique; Inert atmosphere;	100%

: 2632-13-5
2-Bromo-4'-methoxyacetophenone

: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With AcrH2 In acetonitrile at 298℃; for 19h; Irradiation;	100%
With AcrH2 In acetonitrile at 298℃; for 19h; Irradiation;	100%
With decaborane; palladium on activated charcoal In methanol at 20℃; for 2h;	99%

: 99-93-4
4-Hydroxyacetophenone

: 74-88-4
methyl iodide

: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With potassium carbonate In acetone Heating;	100%
With potassium hydroxide; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate at 25℃; for 2h; Williamson synthesis;	99%
With potassium carbonate In acetone Heating;	98%

: 717-14-6
4-methoxyacetophenone semicarbazone

: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With hydrogenchloride; Tonsil In ethyl acetate for 1.5h; Heating;	100%
With CuCl2*2H2O for 0.00277778h; microwave irradiation;	95%
With benzyltriphenylphosphonium dichromate; silica gel for 0.25h;	95%

: 100-66-3
methoxybenzene

: 75-36-5
acetyl chloride

: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With aluminium trichloride; 1-ethyl-3-methyl-1H-imidazol-3-ium chloride at -10℃; for 0.25h;	99%
With zinc at 80 - 82℃; for 0.00194444h; Friedel-Crafts acylation; microwave irradiation;	99%
With indium(III) tosylate In dodecane; nitromethane for 1h; Friedel-Crafts Acylation; Schlenk technique; Reflux;	99%

: 2475-92-5
4-methoxyacetophenone oxime

: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
Stage #1: 4-methoxyacetophenone oxime With hexachlorodisilane; silica gel In toluene at 110℃; for 0.5h; Stage #2: With water In toluene for 0.5h;	99%
With N,N'-dibromo-N,N'-(1,2-ethanediyl)bis(p-toluenesulfonamide) In tetrachloromethane at 20℃; for 2h; Product distribution;	97%
With formaldehyd; sodium dodecyl-sulfate In water at 50℃; for 2h; Ultrasound irradiation;	97%

: 1515-95-3
p-ethylanisole

: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With oxygen In dimethyl sulfoxide at 20℃; under 760.051 Torr; for 6h; Irradiation;	99%
With tert.-butylhydroperoxide In chlorobenzene at 99.84℃; for 10h;	98%
With dihydroxy-methyl-borane; bathophenanthroline; copper (I) acetate; lithium carbonate; N-fluorobis(benzenesulfon)imide In chlorobenzene at 45℃; for 16h;	96%

: 36881-00-2
2-(4-methoxyphenyl)-2-methyI-1,3-dioxolane

: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With cerium triflate In nitromethane; water at 20℃; for 6h;	99%
With water at 120℃; for 0.5h; microwave irradiation;	99%
With Montmorillonite K 10; water In acetone for 0.5h; Heating;	97%

: 19513-78-1
1-(4-methoxy-phenyl)-2-phenoxy-ethanone

: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With ammonium chloride; zinc In ethanol for 0.5h; Heating;	99%
With 2,6-bis[1-(2,6-dimethylphenylimino)ethyl]pyridine cobalt(II)dichloride; bis(pinacol)diborane; sodium t-butanolate In tetrahydrofuran; methanol at 65℃; for 3h; Schlenk technique; Inert atmosphere;	92%
Multi-step reaction with 2 steps 1: sodium tetrahydroborate / tetrahydrofuran; water / 2 h / 20 °C 2: sodium salt of dibutyl phosphate; Methyl thioglycolate; [Ir(ppy)2(dtbpy)]PF6 / N,N-dimethyl acetamide / 24 h / 25 °C / Irradiation; Sealed tube; Inert atmosphere View Scheme

: 19513-80-5
2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)ethan-1-one

A: 90-05-1
2-methoxy-phenol

B: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With formic acid; N-ethyl-N,N-diisopropylamine; Lumogen F Orange 240 In acetonitrile at 25℃; for 8h; Reagent/catalyst; UV-irradiation; Inert atmosphere;	A 99% B 99%
With formic acid; (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; N-ethyl-N,N-diisopropylamine In ethanol at 20℃; Irradiation; chemoselective reaction;	A 95% B 72%
With formic acid; (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 12h; Reagent/catalyst; Irradiation; chemoselective reaction;	A 89% B 88%

: 2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)ethan-1-ol

A: 90-05-1
2-methoxy-phenol

B: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With sodium tetrahydroborate; palladium on activated charcoal In water; ethyl acetate at 80℃; for 1h;	A 95% B 99%
With 5%-palladium/activated carbon; ammonium formate In water at 80℃; for 1h;	A n/a B 98%
With C32H25Cl2N6O2Rh2(1+)*Cl(1-); sodium hydroxide In water at 110℃; for 18h; Inert atmosphere;	A 89% B 86%

: 2040-01-9
2',3',4',5',6'-pentamethylacetophenone

: 100-66-3
methoxybenzene

A: 579-74-8
2-Methoxyacetophenone

B: 700-12-9
pentamethylbenzene,

C: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
trifluoroacetic acid for 20h; Heating;	A n/a B 98% C n/a
With sodium 2,2,2-trifluoroacetate; trifluoroacetic acid for 0.5h; Product distribution; Rate constant; Heating; with various additives and additive amounts;	A n/a B 38% C n/a

...Expand

: 24310-46-1
4-methoxyacetophenone phenylhydrazone

: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With benzyltriphenylphosphonium dichromate; silica gel for 0.116667h;	98%
With 1-benzyl-1-aza-4-azoniabicyclo<2.2.2>octane periodate In acetonitrile for 0.75h; Oxidation; Heating;	97%
With Oxone; water; potassium hydrogencarbonate In acetone for 0.5h; Heating;	97%

: 5757-98-2
p-Methoxyacetophenone N,N-dimethylhydrazone

: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With 1-benzyl-4-aza-1-azoniabiyclo<2.2.2>octane peroxodisulfate In acetonitrile for 0.916667h; Heating;	98%
With Oxone; water; potassium hydrogencarbonate In acetonitrile for 0.5h; Heating;	98%
With benzyltriphenylphosphonium dichromate In acetonitrile for 0.583333h; Oxidation; Heating;	98%

: 108-24-7
acetic anhydride

: 100-66-3
methoxybenzene

A: 64-19-7
acetic acid

B: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With lanthanum(lll) triflate In nitromethane at 50℃; for 24h; Kinetics; Product distribution; Further Variations:; Temperatures; Solvents; Reagents; Friedel-Crafts acylation;	A n/a B 98%
Ce-Clay at 100℃; for 1 - 5h;	A n/a B 35%
La-Clay at 100℃; for 1 - 5h;	A n/a B 15%

...Expand

: 29509-29-3
1-(4-methoxyphenyl)-2-phenoxyethan-1-ol

A: 100-06-1
1-(4-methoxyphenyl)ethanone

B: 108-95-2
phenol

Conditions

Conditions	Yield
With carbonyl bis(hydrido)tris(triphenylphosphine)ruthenium(II); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In toluene at 135℃; for 4h; Inert atmosphere;	A 98% B n/a
With sodium tetrahydroborate; palladium on activated charcoal In water; ethyl acetate at 80℃; for 1h;	A 98% B n/a
With [Ir(ppy)2(dtbpy)]PF6; sodium salt of dibutyl phosphate; Methyl thioglycolate In N,N-dimethyl acetamide at 25℃; for 24h; Reagent/catalyst; Solvent; Irradiation; Sealed tube; Inert atmosphere;	A 86% B 71%

: 19513-80-5
2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)ethan-1-one

: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With 5%-palladium/activated carbon; ammonium formate In ethanol; water at 80℃; for 1h;	98%
With 2,6-bis[1-(2,6-dimethylphenylimino)ethyl]pyridine cobalt(II)dichloride; bis(pinacol)diborane; sodium t-butanolate In tetrahydrofuran; methanol at 65℃; for 3h; Schlenk technique; Inert atmosphere;	89%
With formic acid; (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; N-ethyl-N,N-diisopropylamine In ethanol at 20℃; for 12h; Irradiation; chemoselective reaction;

: 29509-29-3
1-(4-methoxyphenyl)-2-phenoxyethan-1-ol

: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With 5%-palladium/activated carbon; ammonium formate In tert-butyl methyl ether; water at 80℃; for 3h;	98%

: 296278-03-0
1-(4-methoxyphenyl)-2-(naphthalen-2-yloxy)ethan-1-one

: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With 2,6-bis[1-(2,6-dimethylphenylimino)ethyl]pyridine cobalt(II)dichloride; bis(pinacol)diborane; sodium t-butanolate In tetrahydrofuran; methanol at 65℃; for 3h; Schlenk technique; Inert atmosphere;	98%

: 637-69-4
4-Methoxystyrene

A: 3319-15-1
rac-1-(4-methoxyphenyl)-ethanol

B: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With 2.9-dimethyl-1,10-phenanthroline; phenylsilane; iron(II) chloride In ethanol at 20℃; for 4.5h; Reagent/catalyst; Wacker Oxidation;	A 2% B 97%
With triethylsilane; (1,2,3,4,8,9,10,11,15,16,17,18,22,23,24,25-Hexadecafluorophthalocyaninato)iron(II); oxygen In ethanol at 20℃; under 760.051 Torr; for 9.5h; Wacker Oxidation; Sealed tube; Green chemistry; chemoselective reaction;	A 12% B 85%
With sodium hydroxide; sodium tetrahydroborate; oxygen; 5,10,15,20-tetrakis(1-methyl-4-pyridino)porphyrine tertachloride In water Ambient temperature; pH 12;	A 14% B 65%
With triethylsilane; [5,10,15,20-tetra(2,6-dichlorophenyl)porphyrinato]cobalt(II); oxygen; phosphorous acid trimethyl ester 1.) 2-propanol, dichloromethane, 28 deg C, 1 atm, 30 min, 2.) 2-propanol, dichloromethane, RT, 2 h; Yield given. Multistep reaction. Yields of byproduct given;

: 3319-15-1
rac-1-(4-methoxyphenyl)-ethanol

: 74087-85-7
3,3-dimethyldioxirane

A: 4136-21-4
p-methoxybenzoylmethanol

B: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
In acetone at 25℃; for 3h;	A 3% B 97%
In acetone at 25℃; for 3h; Thermodynamic data; Rate constant; Ea, ΔH(excit.), ΔS(excit.), ΔG(excit.);	A 3% B 97%

...Expand

sodium bicarbonate NaHCO3: sodium bicarbonate NaHCO3

triethylaluminum (C2H5)3Al: triethylaluminum (C2H5)3Al

: 100-66-3
methoxybenzene

: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With potassium chloride; acetic anhydride In nitromethane; toluene	97%

...Expand

: 6298-96-0
1-(4-methoxyphenyl)ethanamine

: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With 4-phenylnaphthalene-1,2-dione In acetonitrile at 80℃; for 36h;	97%
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; laccasefrom Trametes versicolor; oxygen In water at 30℃; pH=4.5; Enzymatic reaction;	84%
With caesium carbonate; dibenzoyl peroxide In N,N-dimethyl-formamide at 0 - 50℃;	69%

: 100-52-7
benzaldehyde

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 22966-19-4
trans-4'-methoxychalcone

Conditions

Conditions	Yield
With sodium hydroxide In ethanol for 0.025h; Irradiation;	100%
With 4 A molecular sieve; NAP-MgO In toluene for 16h; Claisen-Schmidt condensation; Heating;	98%
With sodium hydroxide In ethanol at 20℃; Cooling with ice;	95%

: 123-11-5
4-methoxy-benzaldehyde

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 41564-67-4
(E)-1,3-bis(4-methoxyphenyl)-2-propene-1-one

Conditions

Conditions	Yield
With sodium hydroxide In methanol at 20℃; for 20h; Aldol Condensation;	100%
With sodium hydroxide In ethanol at 20℃; for 48h;	99%
With sodium hydroxide In ethanol at 20℃; for 48h; Claisen-Schmidt Condensation;	98%

: 95-92-1
oxalic acid diethyl ester

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 35322-20-4
ethyl 3-(4-methoxybenzoyl)pyruvate

Conditions

Conditions	Yield
Stage #1: 1-(4-methoxyphenyl)ethanone With sodium In ethanol at 20℃; for 0.5h; Stage #2: oxalic acid diethyl ester at 20 - 80℃; for 3h;	100%
With sodium hydride In N,N-dimethyl-formamide at 0 - 100℃;	100%
Stage #1: oxalic acid diethyl ester With sodium methylate In diethyl ether at 20℃; Inert atmosphere; Stage #2: 1-(4-methoxyphenyl)ethanone In diethyl ether at 20℃; for 12h;	92%

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 3319-15-1
rac-1-(4-methoxyphenyl)-ethanol

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol at 0℃; Inert atmosphere;	100%
Stage #1: 1-(4-methoxyphenyl)ethanone With C24H20Cl2F5NRuS; isopropyl alcohol at 82℃; for 0.166667h; Stage #2: With potassium hydroxide at 82℃; for 1h;	100%
With hydrogen; Ru(1,3-dimesityl-2,3-dihydro-1H-imidazol-2-yl)(PPh3)2CO(H)2 In benzene at 70℃; under 3800 Torr; for 24h;	99%

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 2475-92-5
4-methoxyacetophenone oxime

Conditions

Conditions	Yield
With hydroxylamine hydrochloride	100%
With hydroxylamine hydrochloride; sodium acetate In ethanol; water at 95℃;	100%
With pyridine; hydroxylamine hydrochloride In ethanol at 75℃; for 22h;	99%

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 1076-95-5
p-methoxyphenylglyoxal

Conditions

Conditions	Yield
With selenium (IV) oxide In 1,4-dioxane; water Heating;	100%
With tris(2,2'-bipyridyl)ruthenium dichloride; dioxane dibromide; sodium L-ascorbate In acetonitrile at 20℃; for 8h; Irradiation; Green chemistry;	91%
With selenium(IV) oxide In 1,4-dioxane for 3h; Reflux;	88%

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 2632-13-5
2-Bromo-4'-methoxyacetophenone

Conditions

Conditions	Yield
With bromine In 1,4-dioxane; diethyl ether for 0.5h; Ambient temperature;	100%
With N-Bromosuccinimide; toluene-4-sulfonic acid In chloroform at 20℃; for 12h;	98.7%
With bis(dimethylacetamide)hydrogen tribromide In methanol at 20 - 45℃; for 0.25h;	96%

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 1515-95-3
p-ethylanisole

Conditions

Conditions	Yield
With hydrogen under 2250.23 Torr; for 4h;	100%
With palladium dichloride In methanol at 40℃; for 24h; Inert atmosphere; Green chemistry; chemoselective reaction;	99%
With hydrogen In 1,4-dioxane at 200℃; under 15001.5 Torr;	98.9%

: 122-51-0
orthoformic acid triethyl ester

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 1,5-diethoxy-1,5-di(p-methoxyphenyl)penta-2,4-dienylium perchlorate

Conditions

Conditions	Yield
With perchloric acid for 0.666667h;	100%

: 616-38-6
carbonic acid dimethyl ester

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 22027-50-5
methyl 3-(4-methoxybenzoyl)acetate

Conditions

Conditions	Yield
With sodium hydride In toluene at 110℃;	100%
Stage #1: carbonic acid dimethyl ester With sodium hydride In toluene at 110℃; Stage #2: 1-(4-methoxyphenyl)ethanone In toluene at 110℃;	100%
With sodium hydride In toluene for 4h; Inert atmosphere; Reflux;	98%

: 33868-76-7
1-(4-methoxyphenyl)-3,3-bis(methylsulfanyl)propenone

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 78227-65-3
(E)-1,5-Bis-(4-methoxy-phenyl)-3-methylsulfanyl-pent-2-ene-1,5-dione

Conditions

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran for 3h; Ambient temperature;	100%

: 33868-76-7
1-(4-methoxyphenyl)-3,3-bis(methylsulfanyl)propenone

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 78227-65-3
(E)-1,5-Bis-(4-methoxy-phenyl)-3-methylsulfanyl-pent-2-ene-1,5-dione

Conditions

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran Ambient temperature;	100%

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 18212-22-1
4-(4-methoxy-phenyl)-[1,2,3]thiadiazole

Conditions

Conditions	Yield
Stage #1: 1-(4-methoxyphenyl)ethanone With polystyrene-sulfonylhydrazide resin; acetic acid In tetrahydrofuran at 50℃; for 4h; Solid phase reaction; Stage #2: With thionyl chloride In 1,2-dichloro-ethane at 60℃; for 5h; Solid phase reaction; Hurd-Mori cyclization;	100%
With iodine; potassium thioacyanate; toluene-4-sulfonic acid hydrazide; copper dichloride In dimethyl sulfoxide at 100℃; for 1h; Sealed tube;	81%
With iodine; potassium thioacyanate; toluene-4-sulfonic acid hydrazide; copper(l) chloride In dimethyl sulfoxide at 130℃; for 1h;	81%

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 1200-06-2
4-methoxyphenyl acetate

Conditions

Conditions	Yield
With Mg10Al2(OH)24CO3; oxygen; benzaldehyde In 1,2-dichloro-ethane at 40℃; for 24h;	100%
With bis-trimethylsilanyl peroxide; 4 A molecular sieve; tin(IV) chloride; rac-diaminocyclohexane In tetrahydrofuran; dichloromethane for 3h; Ambient temperature;	97%
With 3-chloro-benzenecarboperoxoic acid; scandium tris(trifluoromethanesulfonate) In dichloromethane for 1h; Ambient temperature;	95%

: 139343-81-0
(S(S)R)-(+)-3-methyl-2-pivaloyl-2,3-dihydroisothiazole 1-oxide

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 174736-11-9
N-((R)-1-{2-[(S)-2-(4-Methoxy-phenyl)-2-oxo-ethanesulfinyl]-phenyl}-ethyl)-2,2-dimethyl-propionamide

Conditions

Conditions	Yield
With sodium hexamethyldisilazane In tetrahydrofuran; toluene 1.) -78 deg C, 1 h, 2.) -78 deg C, 1 h; -78 deg C to r.t.;	100%

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 1517-70-0, 1572-97-0, 3319-15-1, 43230-31-5
(S)-1-(4-Methoxyphenyl)ethanol

Conditions

Conditions	Yield
With dimethylsulfide borane complex; 4-chloro-2-(((1S,2R)-1-hydroxy-1-phenylpropan-2-ylamino)methyl)phenol In tetrahydrofuran for 2h; Inert atmosphere; Reflux; optical yield given as %ee; enantioselective reaction;	100%
diethylzinc; (+)-N,N'-Bis<(R)-1-phenylethyl>-1,2-ethylendiamin	99%
With (mer-[(S,S)-1,5-dimethyl-2,4-bis(4-phenyl-1,3-oxazolin-2-yl)benzene(1-)]Ru(CO)Cl)2(ZnCl2); hydrogen; sodium methylate; (-)-(S)-1-Anthracen-9-ylethanol In isopropyl alcohol at 40℃; under 22801.5 Torr; for 24h; Inert atmosphere; Autoclave; optical yield given as %ee; enantioselective reaction;	99%

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 1517-70-0
(R)-1-(4-Methoxyphenyl)ethanol

Conditions

Conditions	Yield
With (S,S)-RuCl2(2,2'-bis(di-3,5-xylylphosphino)-1,1'-binaphthyl)(1,1-dianisyl-2-isopropyl-1,2-ethylenediamine); potassium tert-butylate; hydrogen In isopropyl alcohol at 26 - 30℃; under 7600 Torr; for 1h;	100%
With Trimethyl borate; (S)-diphenylprolinol; dimethylsulfide borane complex In tetrahydrofuran; toluene at 25℃;	99%
With potassium tert-butylate; hydrogen; [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); (R)-Ph-BINAN-H-Py In isopropyl alcohol at 25℃; under 38000 Torr; for 15h;	99.3%

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 2475-92-5
(E)-1-(4-methoxyphenyl)ethanone oxime

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; sodium acetate In methanol Heating;	100%
With hydroxylamine hydrochloride; sodium acetate In methanol; water Reflux;	100%
With hydroxylamine hydrochloride; sodium acetate In methanol Reflux;	100%

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 18096-70-3
3-(dimethylamino)-1-(4-methoxyphenyl)prop-2-en-1-one

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 3.5h; Reflux;	100%
In N,N-dimethyl-formamide for 24h; Reflux;	98%
In neat (no solvent) at 160℃; for 0.25h; Microwave irradiation;	95%

: 50-00-0
formaldehyd

: 31252-42-3
4-benzylpyperidine

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 1037020-22-6
C35H44N2O2

Conditions

Conditions	Yield
With hydrogenchloride In ethanol Mannich reaction; Heating;	100%

...Expand

4'-Methoxyacetophenone Consensus Reports

Reported in EPA TSCA Inventory.

4'-Methoxyacetophenone Standards and Recommendations

DOT Classification: 3; Label: Flammable Liquid

4'-Methoxyacetophenone Specification

The 4'-Methoxyacetophenone with CAS registry number of 100-06-1 is also known as 4-Acetylanisole. The IUPAC name is 1-(4-Methoxyphenyl)ethanone. It belongs to product categories of Acetophenone Series; FINE Chemical & INTERMEDIATES; Aromatic Acetophenones & Derivatives (substituted); Acetophenones (Building Blocks for Liquid Crystals); Building Blocks for Liquid Crystals; Functional Materials. Its EINECS registry number is 202-815-9. In addition, the formula is C₉H₁₀O₂ and the molecular weight is 150.19. This chemical is a white crystals or crystalline powder and should be sealed in ventilated, cool place away from fire, heat. What's more, this chemical is used for the preparation of flavor and it can also be used in organic synthesis.

Physical properties about 4'-Methoxyacetophenone are: (1)ACD/LogP: 1.74; (2)ACD/LogD (pH 5.5): 1.74; (3)ACD/LogD (pH 7.4): 1.74; (4)ACD/BCF (pH 5.5): 12.37; (5)ACD/BCF (pH 7.4): 12.37; (6)ACD/KOC (pH 5.5): 210.65; (7)ACD/KOC (pH 7.4): 210.65; (8)#H bond acceptors: 2; (9)#Freely Rotating Bonds: 2; (10)Index of Refraction: 1.504; (11)Molar Refractivity: 42.95 cm³; (12)Molar Volume: 144.9 cm³; (13)Surface Tension: 33.6 dyne/cm; (14)Density: 1.035 g/cm³; (15)Flash Point: 113.2 °C; (16)Enthalpy of Vaporization: 49.39 kJ/mol; (17)Boiling Point: 256.4 °C at 760 mmHg; (18)Vapour Pressure: 0.0155 mmHg at 25 °C.

Preparation of 4'-Methoxyacetophenone: it is prepared synthetically by Friedel-Crafts acylation of anisole with acetyl chloride.

4'-Methoxyacetophenone is prepared synthetically by Friedel-Crafts acylation of anisole with acetyl chloride.

When you are using this chemical, please be cautious about it. As a chemical, it is irritating to eyes and skin and even harmful by inhalation, in contact with skin and if swallowed. During using it, wear suitable protective clothing, gloves and eye/face protection. If contact with eyes accidently, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: CC(=O)C1=CC=C(C=C1)OC
2. InChI: InChI=1S/C9H10O2/c1-7(10)8-3-5-9(11-2)6-4-8/h3-6H,1-2H3
3. InChIKey: NTPLXRHDUXRPNE-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
human	TCLo	inhalation	1700ug/m³/39W (1.7mg/m³)	CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(4), Pg. 86, 1985.
mouse	LD50	oral	820mg/kg (820mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: IRRITABILITY BEHAVIORAL: MUSCLE WEAKNESS	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(4), Pg. 86, 1985.
rabbit	LD50	skin	> 5gm/kg (5000mg/kg)		Food and Cosmetics Toxicology. Vol. 12, Pg. 927, 1974.
rat	LD50	oral	1720mg/kg (1720mg/kg)		Food and Cosmetics Toxicology. Vol. 12, Pg. 927, 1974.

Product Name

4'-Methoxyacetophenone

Synthetic route

4'-Methoxyacetophenone Consensus Reports

4'-Methoxyacetophenone Standards and Recommendations

4'-Methoxyacetophenone Specification

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