Product Name

  • Name

    4,4'-Dichlorodiphenyl sulfone

  • EINECS 201-247-9
  • CAS No. 80-07-9
  • Article Data108
  • CAS DataBase
  • Density 1.54 g/cm3
  • Solubility water: <0.1 g/100 mL at 20 °C
  • Melting Point 143-146 °C(lit.)
  • Formula C12H8Cl2O2S
  • Boiling Point 419.9 °C at 760 mmHg
  • Molecular Weight 287.166
  • Flash Point 211.2 °C
  • Transport Information
  • Appearance off-white crystals or powder
  • Safety 22-24/25-37/39-26
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 80-07-9 (4,4'-Dichlorodiphenyl sulfone)
  • Hazard Symbols IrritantXi,CorrosiveC
  • Synonyms Sulfone,bis(p-chlorophenyl) (6CI,8CI);1,1'-Sulfonylbis(4-chlorobenzene);4-Chloro-1-(4-chlorophenylsulfonyl)benzene;4-Chlorophenyl sulfone;B 0810;Bis(4-chlorophenyl) sulfone;Di-p-chlorophenyl sulfone;NSC 23899;NSC 38759;NSC 50730;NSC 7207;p,p'-Dichlorodiphenyl sulfone;p-Chlorophenyl sulfone;
  • PSA 42.52000
  • LogP 4.90700

Synthetic route

chlorobenzene
108-90-7

chlorobenzene

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

Conditions
ConditionsYield
With sulfuric acid; trifluoroacetic acid; trifluoroacetic anhydride; Η-β Zeochem at 10 - 53℃; for 4h; Product distribution / selectivity;100%
With sulfuric acid at 20℃; for 4h;95.02%
Stage #1: chlorobenzene With aluminum (III) chloride; thionyl chloride In water at 50 - 90℃; for 3h;
Stage #2: With sulfuric acid; dihydrogen peroxide; acetic acid In water at 80℃; for 3h;
93.8%
bis(4-chlorophenyl)sulfoxide
3085-42-5

bis(4-chlorophenyl)sulfoxide

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

Conditions
ConditionsYield
With dihydrogen peroxide; acetic acid at 80℃; for 2h;99.3%
With tetrabutyl-ammonium chloride; dihydrogen peroxide In water at 95℃; for 5h; Temperature; Reagent/catalyst;97.8%
With N-(n-butyl)tridemorph phosphotungstate; dihydrogen peroxide In benzene at 90℃; for 2h; Catalytic behavior; Temperature;96.2%
4-chlorobenzenesulfonyl chloride
98-60-2

4-chlorobenzenesulfonyl chloride

chlorobenzene
108-90-7

chlorobenzene

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

Conditions
ConditionsYield
iron(III) chloride at 144℃; for 0.333333h; microwave irradiation;95%
With iron(III) chloride at 100 - 120℃;
With aluminium trichloride
With iron(III) chloride at 100 - 120℃;
sodium p-chlorobenzenesulphinate
14752-66-0

sodium p-chlorobenzenesulphinate

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

Conditions
ConditionsYield
With copper diacetate In acetonitrile at 60℃; for 3h;94%
para-dichlorobenzene
106-46-7

para-dichlorobenzene

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

Conditions
ConditionsYield
With aluminum (III) chloride; thionyl chloride at 20℃; for 3h; Temperature;94%
bis(4-chlorophenyl)sulfide
5181-10-2

bis(4-chlorophenyl)sulfide

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

Conditions
ConditionsYield
With sodium bromate In water at 80℃; for 0.5h; Ionic liquid;92%
With palladium; dihydrogen peroxide In methanol at 100℃; for 6h; Green chemistry; chemoselective reaction;90%
With dihydrogen peroxide In methanol at 40℃; for 1.58333h; chemoselective reaction;89%
p-chlorobenzenesulfonyl azide
4547-68-6

p-chlorobenzenesulfonyl azide

chlorobenzene
108-90-7

chlorobenzene

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

Conditions
ConditionsYield
With trifluorormethanesulfonic acid In dichloromethane at 25℃; for 3h; regiospecific reaction;81%
bis(4-chlorophenyl)sulfoxide
3085-42-5

bis(4-chlorophenyl)sulfoxide

A

bis(4-chlorophenyl)sulfide
5181-10-2

bis(4-chlorophenyl)sulfide

B

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

Conditions
ConditionsYield
With [ReOCl3(PPh3)2] In ethanol for 18h; Reflux;A 33%
B 65%
With phenyltrifluorodiazoethane; oxygen; 5,15,10,20-tetraphenylporphyrin In dichloromethane; acetonitrile at 20℃; for 0.5h; Irradiation;
sodium p-chlorobenzenesulphinate
14752-66-0

sodium p-chlorobenzenesulphinate

bis(4-chlorophenyl)iodonium bromide
26018-88-2

bis(4-chlorophenyl)iodonium bromide

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

Conditions
ConditionsYield
With 1-butyl-3-methylimidazolium Tetrafluoroborate at 40℃;62%
sodium p-chlorobenzenesulphinate
14752-66-0

sodium p-chlorobenzenesulphinate

bis(4-chlorophenyl)iodonium tetrafluoroborate

bis(4-chlorophenyl)iodonium tetrafluoroborate

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 50℃; for 4h;55%
chlorobenzene
108-90-7

chlorobenzene

A

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

B

1-chloro-2-(4-chlorophenylsulfonyl)benzene
38980-51-7

1-chloro-2-(4-chlorophenylsulfonyl)benzene

Conditions
ConditionsYield
With cadmium(II) sulfate crystallohydrate; phosphorus pentoxide at 20℃; for 5h; Milling; Sealed tube; Green chemistry;A 53%
B 14%
With sulfur trioxide; dimethyl sulfate at 50℃; for 1.33333h; exclusion of air humidity;
bromochlorobenzene
106-39-8

bromochlorobenzene

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

Conditions
ConditionsYield
With potassium pyrosulfite; palladium diacetate; N-ethyl-N,N-diisopropylamine; tri tert-butylphosphoniumtetrafluoroborate In N,N-dimethyl-formamide at 100℃; for 20h; Inert atmosphere;19%
4-chloro-benzenesulfonic acid
98-66-8

4-chloro-benzenesulfonic acid

chlorobenzene
108-90-7

chlorobenzene

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

Conditions
ConditionsYield
With sulfur trioxide; trifluoroacetic acid at 40 - 100℃; for 8.5h; Product distribution / selectivity; Inert atmosphere;11%
With acetic anhydride at 100 - 120℃; for 3h; Product distribution / selectivity;2%
unter kontinuierlicher Entfernung des gebildeten Wassers;
methyl p-chlorobenzenesulphonate
15481-45-5

methyl p-chlorobenzenesulphonate

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

Conditions
ConditionsYield
With sulfur trioxide anschliessendes Erwaermen mit Chlorbenzol;
chlorobenzene
108-90-7

chlorobenzene

A

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

B

4-chlorobenzenesulfonyl chloride
98-60-2

4-chlorobenzenesulfonyl chloride

Conditions
ConditionsYield
With chlorosulfonic acid
With chlorosulfonic acid at 25℃;
With chlorosulfonic acid; sulfuric acid Edukt 4:SO3;
bis(4-chlorophenyl)sulfide
5181-10-2

bis(4-chlorophenyl)sulfide

A

bis(4-chlorophenyl)sulfoxide
3085-42-5

bis(4-chlorophenyl)sulfoxide

B

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

Conditions
ConditionsYield
With 1-oxo-10-tert-butyl-3,3,7,7-tetrakis(trifluoromethyl)-4,6-benzo-1-ioda-2,8-dioxabicyclo<3.3.0>octane at 130℃; for 24h; other substrates;
chlorobenzene
108-90-7

chlorobenzene

A

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

B

bis(2-chlorophenyl) sulfone
5097-15-4

bis(2-chlorophenyl) sulfone

C

1-chloro-2-(4-chlorophenylsulfonyl)benzene
38980-51-7

1-chloro-2-(4-chlorophenylsulfonyl)benzene

Conditions
ConditionsYield
With antimony pentafluoride; fluorosulphonic acid at 50℃; for 1h; Yield given. Yields of byproduct given;
chlorobenzene
108-90-7

chlorobenzene

A

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

B

p-chlorobenzenesulfonic anhydride
14248-65-8

p-chlorobenzenesulfonic anhydride

Conditions
ConditionsYield
With sulfur trioxideA 6 % Chromat.
B n/a
aluminium trichloride
7446-70-0

aluminium trichloride

4-chlorobenzenesulfonyl chloride
98-60-2

4-chlorobenzenesulfonyl chloride

chlorobenzene
108-90-7

chlorobenzene

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

chlorosulfonic acid
7790-94-5

chlorosulfonic acid

chlorobenzene
108-90-7

chlorobenzene

A

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

B

4-chloro-benzenesulfonic acid
98-66-8

4-chloro-benzenesulfonic acid

C

4-chlorobenzenesulfonyl chloride
98-60-2

4-chlorobenzenesulfonyl chloride

Conditions
ConditionsYield
at -5℃; auch bei Zusatz von wasserfreier Schwefelsaeure;
<4-chloro-phenyl>-<4-amino-phenyl>-sulfone acetate

<4-chloro-phenyl>-<4-amino-phenyl>-sulfone acetate

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

Conditions
ConditionsYield
With sulfuric acid; acetic acid; sodium nitrite Behandeln der erhaltenen Diazoniumsalz-Loesung mit einer Loesung von CuCl in konz. wss. HCl;
chlorobenzene
108-90-7

chlorobenzene

p-chloro-benzenesulfonic acid chloride

p-chloro-benzenesulfonic acid chloride

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

Conditions
ConditionsYield
With aluminium trichloride
disulfuric acid
7783-05-3

disulfuric acid

chlorobenzene
108-90-7

chlorobenzene

A

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

B

4-chloro-benzenesulfonic acid
98-66-8

4-chloro-benzenesulfonic acid

Conditions
ConditionsYield
With sulfuric acid
4-chlorobenzenesulfonyl chloride
98-60-2

4-chlorobenzenesulfonyl chloride

chlorobenzene
108-90-7

chlorobenzene

A

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

B

1-chloro-2-(4-chlorophenylsulfonyl)benzene
38980-51-7

1-chloro-2-(4-chlorophenylsulfonyl)benzene

Conditions
ConditionsYield
iron(III) chloride at 144℃; for 0.333333h; Product distribution / selectivity; Irradiation;
5-p-(p-chlorophenylsulphonyl)phenyl-3-mercapto-1,2,4-triazole
141212-57-9

5-p-(p-chlorophenylsulphonyl)phenyl-3-mercapto-1,2,4-triazole

A

4-Chlorophenyl phenyl sulfone
80-00-2

4-Chlorophenyl phenyl sulfone

B

phenyl p-chlorophenyl sulfide
13343-26-5

phenyl p-chlorophenyl sulfide

C

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

D

1-(4-chlorophenylsulfonyl)-4-cyanobenzene
80988-11-0

1-(4-chlorophenylsulfonyl)-4-cyanobenzene

Conditions
ConditionsYield
at 475℃; under 2 Torr; Pyrolysis; Inert atmosphere;A 12.1 %Chromat.
B 6 %Chromat.
C 3.9 %Chromat.
D 60.6 %Chromat.
5-p-(p-chlorophenylsulphonyl)phenyl-3-mercapto-1,2,4-triazole
141212-57-9

5-p-(p-chlorophenylsulphonyl)phenyl-3-mercapto-1,2,4-triazole

A

4-Chlorophenyl phenyl sulfone
80-00-2

4-Chlorophenyl phenyl sulfone

B

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

C

4-((4- chlorophenyl) thio) benzo nitrile
96461-81-3

4-((4- chlorophenyl) thio) benzo nitrile

D

1-(4-chlorophenylsulfonyl)-4-cyanobenzene
80988-11-0

1-(4-chlorophenylsulfonyl)-4-cyanobenzene

Conditions
ConditionsYield
at 750℃; under 2 Torr; Pyrolysis; Inert atmosphere;A 16 %Chromat.
B 4 %Chromat.
C 5 %Chromat.
D 40.2 %Chromat.
5-p-(p-chlorophenylsulphonyl)phenyl-3-mercapto-1,2,4-triazole
141212-57-9

5-p-(p-chlorophenylsulphonyl)phenyl-3-mercapto-1,2,4-triazole

A

4-Chlorophenyl phenyl sulfone
80-00-2

4-Chlorophenyl phenyl sulfone

B

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

C

1-(4-chlorophenylsulfonyl)-4-cyanobenzene
80988-11-0

1-(4-chlorophenylsulfonyl)-4-cyanobenzene

Conditions
ConditionsYield
at 550℃; under 2 Torr; Pyrolysis; Inert atmosphere;A 10.4 %Chromat.
B 3.8 %Chromat.
C 56 %Chromat.
4,4'-sulfonediphenol
80-09-1

4,4'-sulfonediphenol

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydroxide / water / 2 h / Reflux
1.2: 50 °C / pH 10.85
2.1: sulfuric acid / water / pH 5
View Scheme
Monosodium salt of 4,4'-dihydroxydiphenylsulfone

Monosodium salt of 4,4'-dihydroxydiphenylsulfone

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

Conditions
ConditionsYield
With sulfuric acid In water pH=5;
chlorine-terminated poly(ethylene oxide)

chlorine-terminated poly(ethylene oxide)

4,4'-Dihydroxybiphenyl
92-88-6

4,4'-Dihydroxybiphenyl

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

polysulfone-block-poly(ethylene oxide), Mn = 56000 (GPC), Mw = 67000 (GPC), polydispersity = 1.9 (GPC); monomer(s): chlorine-terminated poly(ethylene oxide); 4,4'-dichlorodiphenyl sulfone; 4,4'-dihydroxybiphenyl

polysulfone-block-poly(ethylene oxide), Mn = 56000 (GPC), Mw = 67000 (GPC), polydispersity = 1.9 (GPC); monomer(s): chlorine-terminated poly(ethylene oxide); 4,4'-dichlorodiphenyl sulfone; 4,4'-dihydroxybiphenyl

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl acetamide; toluene at 160℃; for 20h;100%
4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

bis(4-chloro-3-nitrophenyl)sulfone
1759-05-3

bis(4-chloro-3-nitrophenyl)sulfone

Conditions
ConditionsYield
With sulfuric acid; nitric acid In 1,2-dichloro-ethane99%
With sodium nitrate; sulfuric acid at 80℃;95%
With sulfuric acid; nitric acid In water at 20℃; for 6h;92%
4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

2-hydroxyethanethiol
60-24-2

2-hydroxyethanethiol

2,2’-((sulfonylbis(4,1-phenylene))bis(sulfanediyl))bis(ethan-1-ol)
53680-66-3

2,2’-((sulfonylbis(4,1-phenylene))bis(sulfanediyl))bis(ethan-1-ol)

Conditions
ConditionsYield
With potassium carbonate In ISOPROPYLAMIDE at 150℃; for 5h;98%
With sodium hydride In 1-methyl-pyrrolidin-2-one at 10 - 50℃; for 2h;90%
4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

trimethyltin(IV)chloride
1066-45-1

trimethyltin(IV)chloride

4,4'-sulfonylbis(4,1-phenylene)bis(trimethylstannane)

4,4'-sulfonylbis(4,1-phenylene)bis(trimethylstannane)

Conditions
ConditionsYield
Stage #1: 4,4'-dichlorodiphenyl sulphone With n-butyllithium In tetrahydrofuran at -78℃; for 2h;
Stage #2: trimethyltin(IV)chloride In tetrahydrofuran at -78 - 20℃;
97%
4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

phenylboronic acid
98-80-6

phenylboronic acid

4,4''-sulfonyldi-1,1'-biphenyl
19942-80-4

4,4''-sulfonyldi-1,1'-biphenyl

Conditions
ConditionsYield
With palladium diacetate; 1,3-bis-(diphenylphosphino)propane; cesium fluoride In various solvent(s) at 100℃; for 10h;95%
4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

(p-hydroxyphenyl)boronic acid
71597-85-8

(p-hydroxyphenyl)boronic acid

4,4'-bis(4-hydroxyphenyl)diphenyl sulfone
170275-06-6

4,4'-bis(4-hydroxyphenyl)diphenyl sulfone

Conditions
ConditionsYield
With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; water at 90℃; for 20h;95%
2,6-di-tert-butylphenol
128-39-2

2,6-di-tert-butylphenol

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

4'-<(4-Chlorophenyl)sulfonyl>-3,5-di-tert-butyl-<1,1'-biphenyl>-4-ol
139225-66-4

4'-<(4-Chlorophenyl)sulfonyl>-3,5-di-tert-butyl-<1,1'-biphenyl>-4-ol

Conditions
ConditionsYield
With 2,3-diethynylquinoxaline; potassium tert-butylate; ammonia at -40℃; electrolysis, current density 1.5 A*dm-2;90%
With 2,3-diethynylquinoxaline; potassium tert-butylate In ammonia at -38℃; electrosynthesis: cathode - platinum grid, 10 cm2, 1024 mesh/cm2; anode - magnesium rod, h = 8 cm, Φ = 1 cm; constant current density 0,5 A dm2, KBr as supporting electrolyte;90%
4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

sodium thiophenolate
930-69-8

sodium thiophenolate

C24H18O2S3
93103-32-3

C24H18O2S3

Conditions
ConditionsYield
1-(2'-ethylhexyl)-4-dimethylaminopyridinium chloride In 1,2-dichloro-benzene at 150℃; for 2h;90%
4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

4,4'-dihydrazinodiphenyl sulfone
14052-65-4

4,4'-dihydrazinodiphenyl sulfone

Conditions
ConditionsYield
With hydrazine hydrate; triethylamine for 20h; Heating;90%
With hydrazine hydrate; triethylamine for 24h; Reflux;90%
4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

2-Mercaptobenzothiazole
149-30-4

2-Mercaptobenzothiazole

4,4'-di(2-benzothiazolylthio)diphenyl sulfone
1334840-69-5

4,4'-di(2-benzothiazolylthio)diphenyl sulfone

Conditions
ConditionsYield
With sodium hydride In 1-methyl-pyrrolidin-2-one at 10 - 150℃; for 13h;90%
3,5-dimethoxyphenol
500-99-2

3,5-dimethoxyphenol

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

4,4'-bis(3,5-dimethoxyphenoxy)diphenyl sulfone

4,4'-bis(3,5-dimethoxyphenoxy)diphenyl sulfone

Conditions
ConditionsYield
Stage #1: 3,5-dimethoxyphenol; 4,4'-dichlorodiphenyl sulphone With potassium carbonate In N,N-dimethyl acetamide; toluene at 140℃; for 4h; Dean-Stark; Inert atmosphere;
Stage #2: In N,N-dimethyl-formamide at 150℃; for 1h; Dean-Stark; Inert atmosphere;
90%
With N,N-dimethyl acetamide; potassium carbonate In toluene at 150℃; for 15h; Temperature; Inert atmosphere; Reflux;
4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

ortho-cresol
95-48-7

ortho-cresol

4,4'-bis(2-methylphenyloxy)diphenylsulfone
53895-55-9

4,4'-bis(2-methylphenyloxy)diphenylsulfone

Conditions
ConditionsYield
92%
4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

dapsone
80-08-0

dapsone

Conditions
ConditionsYield
With ammonium chloride In ethanol for 5h; Reflux;91.9%
With ammonia; water; copper; copper(I) bromide at 200℃;
With ammonia; copper(II) sulfate; ethylene glycol at 245℃;
4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

4-tert-butylphenylboronic acid
123324-71-0

4-tert-butylphenylboronic acid

bis(4'-t-butylbiphenyl-4-yl)sulfone

bis(4'-t-butylbiphenyl-4-yl)sulfone

Conditions
ConditionsYield
With sodium phosphate In water; isopropyl alcohol at 85℃; for 2h; Suzuki-Miyaura Coupling;90%
4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

sodium phenoxide
139-02-6

sodium phenoxide

4,4'-sulfonylbis(phenoxybenzene)
1623-91-2

4,4'-sulfonylbis(phenoxybenzene)

Conditions
ConditionsYield
N-2-ethylhexyl chloride of 4(4-methylpiperidinyl)pyridine In 1,2-dichloro-benzene at 180℃; for 2h;87%
(9,9’-(5-(4,4,5,5-tetramethyl-1,2,3-dioxaborolan-2-yl)-1,3-phenylene)bis(9H-carbazole))
1082549-89-0

(9,9’-(5-(4,4,5,5-tetramethyl-1,2,3-dioxaborolan-2-yl)-1,3-phenylene)bis(9H-carbazole))

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

9,9' ,9'' ,9''' -(sulfonylbis([1,1' -biphenyl]-4',3,5-triyl))tetrakis(9H-carbazole)

9,9' ,9'' ,9''' -(sulfonylbis([1,1' -biphenyl]-4',3,5-triyl))tetrakis(9H-carbazole)

Conditions
ConditionsYield
Stage #1: (9,9’-(5-(4,4,5,5-tetramethyl-1,2,3-dioxaborolan-2-yl)-1,3-phenylene)bis(9H-carbazole)); 4,4'-dichlorodiphenyl sulphone With Aliquat 336; potassium carbonate In water; toluene for 0.25h; Inert atmosphere;
Stage #2: With tetrakis(triphenylphosphine) palladium(0) In water; toluene at 130℃; for 12h; Inert atmosphere;
86%
4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

2,5-Dimercapto-1,3,4-thiadiazole
1072-71-5

2,5-Dimercapto-1,3,4-thiadiazole

C16H10N4O2S7

C16H10N4O2S7

Conditions
ConditionsYield
With potassium carbonate at 180℃; for 18h; Temperature; Reagent/catalyst; Inert atmosphere;85.1%
4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

N1,N1,N3,N3-tetraphenyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1,3-diamine

N1,N1,N3,N3-tetraphenyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1,3-diamine

4' ,4"' -sulfonylbis(N3,N3,N5,N5-tetraphenyl-[1,1' -biphenyl]-3,5-diamine)

4' ,4"' -sulfonylbis(N3,N3,N5,N5-tetraphenyl-[1,1' -biphenyl]-3,5-diamine)

Conditions
ConditionsYield
Stage #1: 4,4'-dichlorodiphenyl sulphone; N1,N1,N3,N3-tetraphenyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1,3-diamine With Aliquat 336; potassium carbonate In water; toluene for 0.25h; Inert atmosphere;
Stage #2: With tetrakis(triphenylphosphine) palladium(0) In water; toluene at 130℃; for 12h; Inert atmosphere;
85%
Stage #1: 4,4'-dichlorodiphenyl sulphone; N1,N1,N3,N3-tetraphenyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1,3-diamine With Aliquat 336; potassium carbonate In water; toluene for 0.25h; Inert atmosphere;
Stage #2: With tetrakis(triphenylphosphine) palladium(0) In water; toluene at 130℃; for 12h; Inert atmosphere;
85%
4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

disodium 4,4'-dichlorodiphenylsulfone-3,3'-disulfonate

disodium 4,4'-dichlorodiphenylsulfone-3,3'-disulfonate

Conditions
ConditionsYield
With sulfuric acid; sulfur trioxide at 75 - 160℃; for 4.5h; Large scale;83%
Stage #1: 4,4'-dichlorodiphenyl sulphone With fuming sulphuric acid at 110℃; for 6h;
Stage #2: With sodium chloride In water
Stage #1: 4,4'-dichlorodiphenyl sulphone With sulfuric acid; sulfur trioxide
Stage #2: With sodium chloride
4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

4,4'-sulfonylbis(1-phenylethyl)benzene

4,4'-sulfonylbis(1-phenylethyl)benzene

Conditions
ConditionsYield
With 2.9-dimethyl-1,10-phenanthroline; nickel(II) perchlorate hexahydrate; tetrabutylammomium bromide In N,N-dimethyl acetamide at 20℃; for 10h; Glovebox; Sealed tube; Electrochemical reaction; Inert atmosphere; regioselective reaction;83%
1,2,2,6,6-pentamethyl-piperidin-4-ol
2403-89-6

1,2,2,6,6-pentamethyl-piperidin-4-ol

4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

4,4’-((sulfonylbis(4,1-phenylene))bis(oxy))bis(1,2,2,6,6-pentamethylpiperidine)

4,4’-((sulfonylbis(4,1-phenylene))bis(oxy))bis(1,2,2,6,6-pentamethylpiperidine)

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran for 72h; Reflux; Inert atmosphere;81.8%
4,4'-dichlorodiphenyl sulphone
80-07-9

4,4'-dichlorodiphenyl sulphone

(S)-[1,1']-binaphthalenyl-2,2'-diol
18531-99-2

(S)-[1,1']-binaphthalenyl-2,2'-diol

C44H28Cl2O6S2

C44H28Cl2O6S2

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 150℃; for 9h;80%

4,4'-Dichlorodiphenyl sulfone Chemical Properties

Molecular Structure:

Molecular Formula: C12H8Cl2O2S
Molecular Weight: 287.1617
IUPAC Name: 1-Chloro-4-(4-chlorophenyl)sulfonylbenzene
Synonyms of Bis(p-chlorophenyl) sulfone (CAS NO.80-07-9): 1,1'-Sulfonylbis(4-chlorobenzene) ; 4,4'-Dichlorodiphenyl sulfone ; 4,4'-Dichlorodiphenyl sulphone ; 4-06-00-01587 (Beilstein Handbook Reference) ; 4-Chloro-1-(4-chlorophenylsulfonyl)benzene ; 4-Chlorophenyl sulfone ; AI3-01386 ; AI3-02901 ; BRN 2052955 ; Benzene, 1,1'-sulfonylbis(4-chloro- ; Bis(4-chlorophenyl) sulfone ; CCRIS 8813 ; Di-p-chlorophenyl sulfone ; EINECS 201-247-9 ; HSDB 5233 ; NSC 23899 ; Sulfone, bis(p-chlorophenyl) ; p,p'-Dichlorodiphenyl sulfone ; p-Chlorophenyl sulfone
CAS NO: 80-07-9
Classification Code: Tumor data
Melting point: 143-146 °C 
Index of Refraction: 1.61
Molar Refractivity: 69.93 cm3
Molar Volume: 201.6 cm3
Surface Tension: 48.1 dyne/cm
Density: 1.423 g/cm3
Flash Point: 211.2 °C
Enthalpy of Vaporization: 64.75 kJ/mol
Boiling Point: 419.9 °C at 760 mmHg
Vapour Pressure: 7.18E-07 mmHg at 25°C

4,4'-Dichlorodiphenyl sulfone Uses

 Bis(p-chlorophenyl) sulfone (CAS NO.80-07-9) is used to product 4,4'-diamino-diphenyl sulfone. It is also used as a raw material for engineering plastics polysulfone.

4,4'-Dichlorodiphenyl sulfone Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 24gm/kg (24000mg/kg) BEHAVIORAL: TREMOR Helvetica Chimica Acta. Vol. 29, Pg. 1317, 1946.
rat LDLo oral 7500mg/kg (7500mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" National Technical Information Service. Vol. OTS0533718,

4,4'-Dichlorodiphenyl sulfone Consensus Reports

Reported in EPA TSCA Inventory.

4,4'-Dichlorodiphenyl sulfone Safety Profile

The safety information of Bis(p-chlorophenyl) sulfone (CAS NO.80-07-9) is as follows:
Hazard Codes:Xi ,C
Hazard Note:Harmful/Corrosive/Moisture Sensitive
Risk Statements:36/37/38
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:22-24/25-37/39-26
22:Do not breathe dust
24/25:Avoid contact with skin and eyes
37/39:Wear suitable gloves and eye/face protection
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
WGK Germany:2
RTECS:WR3450000
HS Code:29309070
Mildly toxic by ingestion. See also SULFONATES. When heated to decomposition it emits very toxic fumes of Cl and SOx.

4,4'-Dichlorodiphenyl sulfone Specification

Storage information of Bis(p-chlorophenyl) sulfone (CAS NO.80-07-9):
Store in a cool, dry place. Store in a tightly closed container.

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