Product Name

  • Name

    4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride

  • EINECS 249-220-0
  • CAS No. 28783-41-7
  • Article Data12
  • CAS DataBase
  • Density 1.143g/cm3
  • Solubility
  • Melting Point 212-215°C
  • Formula C7H10ClNS
  • Boiling Point 242.9 °C at 760 mmHg
  • Molecular Weight 175.682
  • Flash Point 100.7 °C
  • Transport Information
  • Appearance Off-White Solid
  • Safety 26-36/37/39-37
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 28783-41-7 (4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride)
  • Hazard Symbols
  • Synonyms Thieno[3,2-c]pyridine,4,5,6,7-tetrahydro-, hydrochloride (8CI,9CI);
  • PSA 40.27000
  • LogP 2.52460

Synthetic route

[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

formaldehyd
50-00-0

formaldehyd

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

Conditions
ConditionsYield
Stage #1: [2-(2-thyenyl)ethyl]amine; formaldehyd In dichloromethane at 40 - 45℃;
Stage #2: With hydrogenchloride In dichloromethane; water; N,N-dimethyl-formamide at 20 - 70℃;		99%
Stage #1: [2-(2-thyenyl)ethyl]amine; formaldehyd In toluene for 1.5h; Reflux; Inert atmosphere; Dean-Stark;
Stage #2: With hydrogenchloride In 1,4-dioxane; toluene at 60℃; for 0.5h; Inert atmosphere;		98%
Stage #1: [2-(2-thyenyl)ethyl]amine; formaldehyd In 1,2-dichloro-ethane for 4h; Heating / reflux;
Stage #2: With hydrogenchloride In 1,2-dichloro-ethane; N,N-dimethyl-formamide at 70℃; for 4h;		90%
N-methoxycarbonyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine
68559-49-9

N-methoxycarbonyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

Conditions
ConditionsYield
Stage #1: N-methoxycarbonyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine With sodium hydroxide In methanol for 12h; Reflux;
Stage #2: With hydrogenchloride In 1,4-dioxane pH=1;		82%
N-methylene-2-(thien-2-yl)ethanamine
111954-31-5

N-methylene-2-(thien-2-yl)ethanamine

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In N,N-dimethyl-formamide
With hydrogenchloride In isopropyl alcohol at 60℃; for 5h;
dihydro-6,7 thieno<3,2-c>pyridine
107112-93-6

dihydro-6,7 thieno<3,2-c>pyridine

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

Conditions
ConditionsYield
Stage #1: dihydro-6,7 thieno<3,2-c>pyridine With methanol; sodium tetrahydroborate at 20℃; for 2h;
Stage #2: With hydrogenchloride
2-thiophenethanol
5402-55-1

2-thiophenethanol

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: triethylamine / dichloromethane / 2 h / -5 - 20 °C
2: formic acid / 8.5 h / 80 °C / Inert atmosphere
3: trifluoroacetic acid / 20 °C
4: sodium tetrahydroborate; methanol / 2 h / 20 °C
View Scheme
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: formic acid / 8.5 h / 80 °C / Inert atmosphere
2: trifluoroacetic acid / 20 °C
3: sodium tetrahydroborate; methanol / 2 h / 20 °C
View Scheme
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

6,7-dihydro-4H-thieno[3,2-c]-pyridine-5-carboxylic acid tert-butyl ester
230301-73-2

6,7-dihydro-4H-thieno[3,2-c]-pyridine-5-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 2h;100%
With triethylamine In dichloromethane at 20℃; for 4.5h;100%
With triethylamine In dichloromethane at 20℃; for 6h;92.3%
Stage #1: 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride With potassium carbonate In 1,4-dioxane at 80℃; for 0.5h;
Stage #2: di-tert-butyl dicarbonate In 1,4-dioxane for 1h;		16.8 g
trityl chloride
76-83-5

trityl chloride

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

5-trityl-4,5,6,7-tetrahydro-tieno[3,2-c]pyridine
109904-25-8

5-trityl-4,5,6,7-tetrahydro-tieno[3,2-c]pyridine

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 2h; Inert atmosphere;100%
With triethylamine In dichloromethane at 12 - 28℃;99%
With N-ethyl-N,N-diisopropylamine In acetonitrile for 3h;94%
C15H13ClO5S

C15H13ClO5S

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With sodium carbonate In dichloromethane at 25 - 40℃; for 24h; Temperature;97.02%
6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

benzyl chloride
100-44-7

benzyl chloride

5-benzyl-4,5,6,7-tetrahydro-thieno[3,2-c]-pyridine
55142-78-4

5-benzyl-4,5,6,7-tetrahydro-thieno[3,2-c]-pyridine

Conditions
ConditionsYield
With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate In acetonitrile at 70℃;97%
6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

4,5,6,7-tetrahydrothieno[3,2-c]pyridine
54903-50-3

4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Conditions
ConditionsYield
With water; potassium hydroxide In toluene at 25 - 30℃;96.5%
With sodium hydroxide In dichloromethane at 20℃; for 3.5h;3.12 g
methyl (R)-2-(2-chlorophenyl)-2-benzenesulfonyloxyacetate
223123-46-4

methyl (R)-2-(2-chlorophenyl)-2-benzenesulfonyloxyacetate

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

(S)-(+)-clopidogrel bisulfate
120202-66-6

(S)-(+)-clopidogrel bisulfate

Conditions
ConditionsYield
Stage #1: methyl (R)-2-(2-chlorophenyl)-2-benzenesulfonyloxyacetate; 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride With sodium hydrogencarbonate In acetone for 6h; Reflux;
Stage #2: With sulfuric acid In acetone		95.2%
6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-carbaldehyde
29079-79-6

4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-carbaldehyde

Conditions
ConditionsYield
With molybdenum (IV) sulfide at 150℃; for 18h;95%
at 150℃; for 96h; Inert atmosphere; Sealed tube;89%
With graphene oxide at 150℃; for 18h; Sealed tube;81%
(R)-2-(2-chlorophenyl)-2-(4-nitrobenzenesulfonyloxy)acetic acid methyl ester

(R)-2-(2-chlorophenyl)-2-(4-nitrobenzenesulfonyloxy)acetic acid methyl ester

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

(S)-(+)-clopidogrel bisulfate
120202-66-6

(S)-(+)-clopidogrel bisulfate

Conditions
ConditionsYield
Stage #1: (R)-2-(2-chlorophenyl)-2-(4-nitrobenzenesulfonyloxy)acetic acid methyl ester; 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride With potassium carbonate In acetone at 20℃; for 24h;
Stage #2: With sulfuric acid In acetone		93.1%
6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

C8H9NOS*ClH

C8H9NOS*ClH

Conditions
ConditionsYield
With manganese(II) chloride tetrahydrate at 150℃; for 10h; Inert atmosphere; Sealed tube;93%
6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

1-(((2R,3R)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole
135270-13-2

1-(((2R,3R)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole

C19H20F2N4OS

C19H20F2N4OS

Conditions
ConditionsYield
With magnesium 2-methylpropan-2-olate In acetonitrile for 16h; Inert atmosphere; Reflux;93%
6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

cyclopropanecarboxylic acid chloride
4023-34-1

cyclopropanecarboxylic acid chloride

cyclopropyl(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)methanone

cyclopropyl(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)methanone

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0℃; for 1h;93%
6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

methyl 2-bromo-2-(2-chlorophenyl)acetate
85259-19-4

methyl 2-bromo-2-(2-chlorophenyl)acetate

clopidogrel bisulfate
135046-48-9

clopidogrel bisulfate

Conditions
ConditionsYield
Stage #1: 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride With sodium carbonate In water at 25℃; for 0.5h;
Stage #2: methyl 2-bromo-2-(2-chlorophenyl)acetate In water; toluene at 20℃; for 12h;
Stage #3: With sulfuric acid In ethyl acetate for 1h; Reagent/catalyst; Solvent;		90%
Stage #1: 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride; methyl 2-bromo-2-(2-chlorophenyl)acetate With potassium carbonate In acetone
Stage #2: With sulfuric acid
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

2-bromo-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylic acid tert-butyl ester
949922-62-7

2-bromo-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: di-tert-butyl dicarbonate; 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride With tert-butyl methyl ether; sodium hydroxide In water at 0℃;
Stage #2: With bromine In water at 0 - 20℃; for 1.5h;		88.32%
α-bromo-2-chlorophenyl acetic acid
29270-30-2

α-bromo-2-chlorophenyl acetic acid

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetic acid
90055-55-3

2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetic acid

Conditions
ConditionsYield
Stage #1: α-bromo-2-chlorophenyl acetic acid; 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride With potassium hydroxide In methanol; water at 10 - 40℃; for 3h;
Stage #2: With hydrogenchloride In methanol; water at 5 - 20℃; for 4h; pH=3.5;		88%
Stage #1: α-bromo-2-chlorophenyl acetic acid; 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride With potassium hydroxide In methanol; water at 15 - 40℃; for 3h;
Stage #2: With hydrogenchloride In methanol; water at 20℃; for 2h; pH=3.5;		88%
Stage #1: 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride With sodium hydroxide In water at 20 - 35℃;
Stage #2: α-bromo-2-chlorophenyl acetic acid In water at 20 - 27℃;
Stage #3: With hydrogenchloride In water; ethyl acetate at 20 - 30℃; pH=3.5 - 4.5;
With potassium hydroxide In water at 0 - 20℃; for 24h;12 g
sodium cyanide
143-33-9

sodium cyanide

2-chloro-benzaldehyde
89-98-5

2-chloro-benzaldehyde

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetonitrile
444728-11-4

2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetonitrile

Conditions
ConditionsYield
Stage #1: sodium cyanide; 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride In methanol; water for 0.666667h;
Stage #2: 2-chloro-benzaldehyde In methanol; water at 23 - 50℃; for 6h;
Stage #3: With sodium metabisulfite In methanol; water at 25 - 30℃; for 2h;		87.4%
...Expand
6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

(+/-)α-chloro-2-(2-chlorophenyl)acetonitrile
5829-89-0

(+/-)α-chloro-2-(2-chlorophenyl)acetonitrile

2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetonitrile
444728-11-4

2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetonitrile

Conditions
ConditionsYield
With sodium hydrogencarbonate In butan-1-ol for 3h; Product distribution / selectivity; Heating / reflux;86%
2-bromo-2-(2-chlorophenyl)acetonitrile
444891-19-4

2-bromo-2-(2-chlorophenyl)acetonitrile

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetonitrile
444728-11-4

2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetonitrile

Conditions
ConditionsYield
With sodium hydrogencarbonate In methanol for 3h; Product distribution / selectivity; Heating / reflux;85%
With sodium hydrogencarbonate In methanol for 3h; Heating / reflux;85%
6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

p-acetylaminobenzenesulfonyl chloride
121-60-8

p-acetylaminobenzenesulfonyl chloride

N-(4-{6,7-dihydrothieno[3,2-c]pyridin-5(4H)-ylsulfonyl}phenyl)acetamide
949779-15-1

N-(4-{6,7-dihydrothieno[3,2-c]pyridin-5(4H)-ylsulfonyl}phenyl)acetamide

Conditions
ConditionsYield
With triethylamine In acetonitrile for 5h; Reflux;84.5%
6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

thieno[3,2-c]pyridine
272-14-0

thieno[3,2-c]pyridine

Conditions
ConditionsYield
Stage #1: 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride With water; sodium hydroxide In dichloromethane at 20℃;
Stage #2: With manganese(IV) oxide In toluene at 140℃; for 24h;		84.42%
Stage #1: 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride With sodium hydroxide In water for 2h;
Stage #2: With manganese(IV) oxide In toluene at 130℃;		650 mg
1-isocyanocyclohexene
1121-57-9

1-isocyanocyclohexene

2-chloro-benzaldehyde
89-98-5

2-chloro-benzaldehyde

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

2-(2-chlorophenyl)-N-cyclohex-2-enyl-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetamide
1130832-62-0

2-(2-chlorophenyl)-N-cyclohex-2-enyl-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetamide

Conditions
ConditionsYield
Stage #1: 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride With triethylamine In methanol at 20℃; for 0.0833333h;
Stage #2: 2-chloro-benzaldehyde In methanol at 20℃; for 1h; Ugi reaction;
Stage #3: 1-isocyanocyclohexene With formic acid In methanol at 60℃; for 1h; Ugi reaction; Microwave irradiation;		83%
...Expand
6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

Cinnamyl bromide
4392-24-9

Cinnamyl bromide

5-cinnamyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
1581720-50-4

5-cinnamyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Conditions
ConditionsYield
Stage #1: 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride With sodium hydroxide In water at 0 - 25℃; for 0.166667h; Inert atmosphere;
Stage #2: Cinnamyl bromide With triethylamine In tetrahydrofuran; water for 0.333333h; Inert atmosphere;		76%
formaldehyd
50-00-0

formaldehyd

tanshinone IIA
568-72-9

tanshinone IIA

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

C27H27NO3S

C27H27NO3S

Conditions
ConditionsYield
With copper diacetate; acetic acid In dimethyl sulfoxide at 60℃;76%
...Expand
(R)-2-(2-chlorophenyl)-2-(4-nitro sulfonyloxy)acetic acid methyl ester-d3

(R)-2-(2-chlorophenyl)-2-(4-nitro sulfonyloxy)acetic acid methyl ester-d3

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

(S)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetic acid methyl ester-d3
1093351-48-4

(S)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetic acid methyl ester-d3

Conditions
ConditionsYield
With potassium hydrogencarbonate In acetonitrile at 20℃; for 24h; Inert atmosphere;73.6%
5-bromo-2,3-dihydro-2,2-dimethyl-7-(4-bromo-butoxy)-benzofuran
1089210-23-0

5-bromo-2,3-dihydro-2,2-dimethyl-7-(4-bromo-butoxy)-benzofuran

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

1-[(5-bromo-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl)-oxy]-4-(4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-5-yl)-butane
1089209-66-4

1-[(5-bromo-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl)-oxy]-4-(4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-5-yl)-butane

Conditions
ConditionsYield
With sodium hydroxide; triethylbutylammonium chloride In chloroform; water at 20 - 60℃; for 28h;73.3%
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone
204205-33-4

2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

1-cyclopropyl-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2-fluorophenyl)ethanone hydrobromide salt
1287752-37-7

1-cyclopropyl-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2-fluorophenyl)ethanone hydrobromide salt

Conditions
ConditionsYield
Stage #1: 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride With potassium hydrogencarbonate at 20℃; for 0.5h;
Stage #2: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone In acetonitrile at 20℃; for 25h;
Stage #3: With hydrogen bromide In water; acetone at 10 - 20℃; for 3h; Reagent/catalyst;		73.1%
Multi-step reaction with 2 steps
1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C
2: hydrogen bromide / water; acetone / 5.25 h / 0 - 30 °C
View Scheme
6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

4'-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-ylmethyl)biphenyl-2-carbonitrile
938904-49-5

4'-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-ylmethyl)biphenyl-2-carbonitrile

Conditions
ConditionsYield
With potassium carbonate In methanol72%
6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

propargyl bromide
106-96-7

propargyl bromide

5-(prop-2-yn-1-yl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

5-(prop-2-yn-1-yl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 16h;72%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 16h;72%
6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

tert-butyl 4-(2-iodoethyl)piperidine-1-carboxylate
89151-46-2

tert-butyl 4-(2-iodoethyl)piperidine-1-carboxylate

5-<2-(N-Boc-4-piperidinyl)ethyl>-4,5,6,7-tetrahydrothieno<3,2-c>pyridine
158149-68-9

5-<2-(N-Boc-4-piperidinyl)ethyl>-4,5,6,7-tetrahydrothieno<3,2-c>pyridine

Conditions
ConditionsYield
With sodium hydroxide; Aliquat 336 In dichloromethane for 20h;70%
With sodium hydroxide In dichloromethane

4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride Chemical Properties

IUPAC Name:4,5,6,7-tetrahydrothieno[3,2-c]pyridin-1-ium chloride
Molecular Formula:C7H10ClNS
Molecular Weight:175.679000 g/mol
Melting Point:212-215°C
CAS DataBase Reference:28783-41-7(CAS DataBase Reference)
Synonyms of 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride(28783-41-7):
4,5,6,7-TETRAHYDROTHIENO[3,2,C] PYRIDINE HCL;4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDINE HYDROCHLORIDE;4,5,6,7-tetrahydrotieno[3,2-c]pyridinium chloride;4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDINE HCl(TTP);4,5,6,7-tetrahydrothieno[3,2-c]pyridinium chloride;Tetrahydrothieno pyridine HCl;4,5,6,7-Tetrahydrothieon[3,2-C]pyridine,HCl;4,5,6,7-Tetrahydrothieon[3,2-C]pyridine,hydrochloride
Categories of 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride(28783-41-7):
Heterocyclic Compounds;Bases & Related Reagents;Heterocycles;Nucleotides;Sulfur & Selenium Compounds

4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride Uses

4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride(28783-41-7) is used as an intermediate for Plavix which is an anti-thrombosis drug.

4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride Safety Profile

Safety Information of 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride(28783-41-7):
Risk Statements:36/37/38
36/37/38:Irritating to eyes, respiratory system and skin 
Safety Statements:26-36/37/39
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
36/37/39:Wear suitable protective clothing, gloves and eye/face protection 

Related Products

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View