4-Chloro-4'-hydroxybenzophenone supplier

Name
4-Chloro-4'-hydroxybenzophenone
EINECS 255-627-4
CAS No. 42019-78-3
Article Data41
CAS DataBase
Density 1.307 g/cm³
Solubility
Melting Point 177-181 °C
Formula C₁₃H₉ClO₂
Boiling Point 404 ºC at 760 mmHg
Molecular Weight 232.666
Flash Point 198.1ºC
Transport Information
Appearance light grey to beige-brown powder
Safety 24/25-37/39-26-36
Risk Codes 36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xi,Xn
Synonyms Benzophenone,4-chloro-4'-hydroxy- (6CI);(4-Chlorophenyl)(4-hydroxyphenyl)methanone;1-(4-Chlorophenyl)-1-(4-hydroxyphenyl)methanone;4-(4-Chlorobenzoyl)phenol;
PSA 37.30000
LogP 3.27660

Synthetic route

: C19H23ClO2Si

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Schlenk technique;	97%

: 2069-48-9
4-chloro-4'-fluoro-benzophenone

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
With sodium hydroxide In water; dimethyl sulfoxide at 120℃; for 16h; Inert atmosphere; Schlenk technique;	94%
With potassium hydroxide In water; dimethyl sulfoxide at 60℃; for 18h;

: 10547-60-1
4-chloro-4'-methoxybenzophenone

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid In water at 125℃; Reagent/catalyst;	94%
With boron tribromide In tetrahydrofuran at -78 - 20℃; for 2h;	92%
With aluminum (III) chloride In toluene at 0 - 100℃; for 4h;	90%

: 873-73-4
4-n-chlorophenylacetylene

: 106-51-4
p-benzoquinone

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; trifluoroacetic acid In water; acetonitrile at 25℃; for 6h; Irradiation;	90%

: 623-03-0
4-Cyanochlorobenzene

: 108-95-2
phenol

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
With hydrogenchloride; zinc(II) chloride In water; 1,2-dichloro-ethane at 90℃; for 7h; Reflux;	88.1%
Stage #1: 4-Cyanochlorobenzene; phenol With hydrogenchloride; zinc(II) chloride In 1,2-dichloro-ethane at 90℃; Stage #2: With hydrogenchloride; water In 1,2-dichloro-ethane at 20℃; for 5h; Temperature; Reflux;	88.2%

: 873-73-4
4-n-chlorophenylacetylene

: 108-95-2
phenol

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
With oxygen; copper(l) chloride In acetonitrile at 25 - 28℃; for 20h; Irradiation; regioselective reaction;	86%

: 164852-89-5
4-((4-chlorophenyl)(hydroxy)methyl)phenol

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
With oxygen; Langlois reagent In acetonitrile at 25℃; under 760.051 Torr; for 12h; Irradiation;	76%

: 1871-38-1
phenyl 4-chlorobenzoate

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
With aluminium trichloride for 0.0833333h;	41.3%
With aluminium trichloride

: 1871-38-1
phenyl 4-chlorobenzoate

A: 42019-78-3
4-chloro-4'-hydroxybenzophenone

B: 2985-79-7
4'-chloro-2-hydroxybenzophenone

Conditions

Conditions	Yield
With aluminium trichloride

: 4913-77-3
4-amino-4'-chlorobenzophenone

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
With ethanol; sulfuric acid; sodium nitrite
Multi-step reaction with 2 steps 1: sodium nitrite; alcoholic sulfuric acid / Diazotization.und nachfolgenden Kochen 2: glacial acetic acid; hydrobromic acid View Scheme

: 71783-49-8
4-ethoxy-4'-chloro-benzophenone

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid

: 74-11-3
para-chlorobenzoic acid

: 108-95-2
phenol

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
With PPA

: 122-01-0
4-chloro-benzoyl chloride

: 100-66-3
methoxybenzene

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
With sodium hydroxide; aluminium trichloride 1.) dichloroethane, 50 deg C, 6 h; Multistep reaction;
With aluminium trichloride
With aluminum (III) chloride In toluene at 0℃; for 1.5h; Inert atmosphere; Reflux;

: fenofibric acid sodium salt

A: 42019-78-3
4-chloro-4'-hydroxybenzophenone

B: (4-chlorophenyl)(4-isopropoxyphenyl)methanone

C: 4-chloro-4'-(1-hydroxy-1-methylethyl)benzophenone

Conditions

Conditions	Yield
With oxygen In methanol Product distribution; Further Variations:; Reagents; reagents conc.; photolysis; Irradiation;

...Expand

: 122-01-0
4-chloro-benzoyl chloride

potassium hexacyanoferrate(II): potassium hexacyanoferrate(II)

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: AlCl3 / nitrobenzene 2: aq. HBr; AcOH View Scheme

: 100-66-3
methoxybenzene

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: AlCl3 / nitrobenzene 2: aq. HBr; AcOH View Scheme
Multi-step reaction with 2 steps 1: aluminum (III) chloride / dichloromethane / 0 - 20 °C / Inert atmosphere 2: aluminum (III) chloride / toluene / 2 h / 130 °C / Inert atmosphere View Scheme
Multi-step reaction with 2 steps 1: aluminum (III) chloride / dichloromethane / 3 h / 20 °C 2: aluminum (III) chloride / toluene / 4 h / 0 - 100 °C View Scheme

: 462-06-6
fluorobenzene

nitric acid sulfuric acid-water mixture: nitric acid sulfuric acid-water mixture

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 45 percent / trifluoromethylsulphonic acid / 144 h 2: KOH / H2O; dimethylsulfoxide / 18 h / 60 °C View Scheme

: 122-01-0
4-chloro-benzoyl chloride

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 45 percent / trifluoromethylsulphonic acid / 144 h 2: KOH / H2O; dimethylsulfoxide / 18 h / 60 °C View Scheme
Multi-step reaction with 2 steps 1: aqueous NaOH 2: AlCl3 View Scheme
Multi-step reaction with 2 steps 1: aqueous NaOH 2: AlCl3 View Scheme

: 108-95-2
phenol

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aqueous NaOH 2: AlCl3 View Scheme
Multi-step reaction with 2 steps 1: aqueous NaOH 2: AlCl3 View Scheme

: 103-73-1
Phenetole

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aluminium chloride; carbon disulfide 2: glacial acetic acid; hydrobromic acid View Scheme

: 122-01-0
4-chloro-benzoyl chloride

: 108-95-2
phenol

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
aluminium chloride
aluminium chloride
Stage #1: phenol; aluminum (III) chloride In 1,2-dichloro-benzene at 30℃; for 2h; Stage #2: 4-chloro-benzoyl chloride In 1,2-dichloro-benzene at 30 - 80℃; for 5h; Stage #3: With hydrogenchloride In water; 1,2-dichloro-benzene at 30℃;

: 622-32-2
(Z)-benzaldehyde oxime

: 7497-60-1
(4-Chlorophenyl)(4-nitrophenyl)methanone

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
In dimethyl sulfoxide

: C29H17Cl5NO6Pol

A: C17H9Cl4F3NO4Pol

B: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
With trifluoroacetic acid polystyrene ((aminomethyl)polystyrene); Product distribution / selectivity;

: 1765-93-1
4-fluoroboronic acid

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: C42H36ClFeN2O4PPdS*C6H15N; sodium carbonate / water; toluene / 1 h / 50 °C / Inert atmosphere; Schlenk technique 2: sodium hydroxide / water; dimethyl sulfoxide / 16 h / 120 °C / Inert atmosphere; Schlenk technique View Scheme

: 403-43-0
4-fluorobenzoyl chloride

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: C42H36ClFeN2O4PPdS*C6H15N; sodium carbonate / water; toluene / 1 h / 50 °C / Inert atmosphere; Schlenk technique 2: sodium hydroxide / water; dimethyl sulfoxide / 16 h / 120 °C / Inert atmosphere; Schlenk technique View Scheme

: 1679-18-1
4-Chlorophenylboronic acid

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: C42H36ClFeN2O4PPdS*C6H15N; sodium carbonate / water; toluene / 1 h / 50 °C / Inert atmosphere; Schlenk technique 2: sodium hydroxide / water; dimethyl sulfoxide / 16 h / 120 °C / Inert atmosphere; Schlenk technique View Scheme

: 159191-56-7
(4-((tert-butyldimethylsilyl)oxy)phenyl)boronic acid

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: C42H36ClFeN2O4PPdS*C6H15N; sodium carbonate / water; toluene / 1 h / 50 °C / Inert atmosphere; Schlenk technique 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Schlenk technique View Scheme

: 4-chloro-4'-methoxy-benzhydrylamine

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: dichloromethane / 0.17 h / 0 - 20 °C 2: 2,4,6-triphenylpyrylium tetrafluoroborate / 8 h / 35 °C / Irradiation 3: boron tribromide / tetrahydrofuran / 2 h / -78 - 20 °C View Scheme

: (4-chlorophenyl)(4-methoxyphenyl)methanimine

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: sodium tetrahydroborate / methanol / 60 °C 2: dichloromethane / 0.17 h / 0 - 20 °C 3: 2,4,6-triphenylpyrylium tetrafluoroborate / 8 h / 35 °C / Irradiation 4: boron tribromide / tetrahydrofuran / 2 h / -78 - 20 °C View Scheme

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

: 540-63-6
ethane-1,2-dithiol

: 4-(2-(4-chlorophenyl)-1,3-dithiolan-2-yl)phenol

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; Inert atmosphere;	99%

: 109-80-8
1.3-propanedithiol

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

: 4-(2-(4-chlorophenyl)-1,3-dithian-2-yl)phenol

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; Inert atmosphere;	99%

: 345-83-5
4-fluorobenzophenone

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

poly(ether ketone): poly(ether ketone)

Conditions

Conditions	Yield
Stage #1: 4-chloro-4'-hydroxybenzophenone With potassium carbonate In diphenyl sulphone at 135 - 330℃; for 5.5h; Stage #2: 4-fluorobenzophenone In diphenyl sulphone for 0.5h; Product distribution / selectivity;	96%
Stage #1: 4-chloro-4'-hydroxybenzophenone With potassium carbonate In diphenyl sulphone at 135 - 330℃; for 5.5h; Stage #2: 4-fluorobenzophenone In diphenyl sulphone for 0.5h; Product distribution / selectivity;	95%

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

: 164852-89-5
4-((4-chlorophenyl)(hydroxy)methyl)phenol

Conditions

Conditions	Yield
With methanol; sodium tetrahydroborate at 0 - 20℃;	95%

: 1214-24-0
3,6-dihydroxy-xanthen-9-one

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

: 123853-75-8
3,6-bis-(4'-(4''-chlorobenzoyl)phenoxy)xanthone

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl acetamide; toluene Heating;	81.2%

: 1008-89-5
2-phenylpyridine

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

: (4-hydroxyphenyl)(2'-(pyridin-2-yl)biphenyl-4-yl)methanone

Conditions

Conditions	Yield
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; 1-methyl-2-phenyl-3-(diphenylphosphino)-1H-indole; potassium carbonate In 1-methyl-pyrrolidin-2-one at 120℃; for 24h; Schlenk technique; Inert atmosphere; Sealed tube;	81%

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

: 389634-34-8
4,4'-bis[4''-(4'''-chlorobenzoyl)phenoxy](hexafluoroisopropylidene)dibenzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl acetamide; toluene for 3.5h; Heating;	80%

: 700-58-3
2-Adamantanone

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

: 4-((Z)-((5S,7S)-adamantan-2-ylidene)(4-chlorophenyl)methyl)phenol

Conditions

Conditions	Yield
With titanium tetrachloride; zinc In tetrahydrofuran at -78 - 20℃; for 5h; Cooling with acetone-dry ice; Reflux;	80%

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

: 75-36-5
acetyl chloride

: 4-acetoxy-4'-chlorobenzophenone

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 60℃; for 15h; Inert atmosphere; Schlenk technique;	78%
With triethylamine In benzene Heating;

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

: 106-93-4
ethylene dibromide

: 160412-57-7
[4-(2-bromoethoxy)phenyl]-(4-chlorophenyl)methanone

Conditions

Conditions	Yield
With potassium carbonate In acetone Heating;	75%

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

: 120-92-3
cyclopentanone

: 4-((4-chlorophenyl)(cyclopentylidene)methyl)phenol

Conditions

Conditions	Yield
With titanium tetrachloride; zinc In tetrahydrofuran for 2h; Inert atmosphere; Reflux;	74%

: 67-66-3
chloroform

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

: 67-64-1
acetone

: 42017-89-0
fenofibric acid

Conditions

Conditions	Yield
Stage #1: 4-chloro-4'-hydroxybenzophenone; acetone With sodium hydroxide for 2h; Heating / reflux; Stage #2: chloroform In acetone for 8h; Heating / reflux;	73%
With sodium hydroxide
With sodium hydroxide

...Expand

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

: 25333-24-8
3-benzoylpropionic acid methyl ester

: (E)-methyl 5-(4-chlorophenyl)-5-(4-hydroxyphenyl)-4-phenylpent-4-enoate

Conditions

Conditions	Yield
With titanium tetrachloride; zinc In tetrahydrofuran at 0 - 60℃; for 3h; McMurry Reaction;	73%

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

: 3068-31-3
1-bromo-2,3,4-tri-O-acetyl-α-D-xylopyranose

: 99482-83-4
4-(4-chlorobenzoyl)phenyl 2,3,4-tri-O-acetyl-β-D-xylopyranoside

Conditions

Conditions	Yield
With silver(l) oxide In acetonitrile for 0.5h; Ambient temperature;	72%

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

: 572-09-8
2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide

: Acetic acid (2R,3R,4S,5R,6S)-3,5-diacetoxy-2-acetoxymethyl-6-[4-(4-chloro-benzoyl)-phenoxy]-tetrahydro-pyran-4-yl ester

Conditions

Conditions	Yield
With silver(l) oxide In acetonitrile for 0.5h; Ambient temperature;	71%

: 600-00-0
ethyl 2-bromoisobutyrate

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

: 123-41-1
cholin hydroxide

: 856676-23-8
choline fenofibrate

Conditions

Conditions	Yield
Stage #1: ethyl 2-bromoisobutyrate; 4-chloro-4'-hydroxybenzophenone With potassium carbonate at 145℃; for 3h; Stage #2: cholin hydroxide In propan-1-ol; water for 3h; Heating / reflux;	70%

...Expand

: 75-61-6
dibromodifluoromethane

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

: 229027-51-4
[4-(bromo-difluoro-methoxy)-phenyl]-(4-chloro-phenyl)-methanone

Conditions

Conditions	Yield
Stage #1: 4-chloro-4'-hydroxybenzophenone With sodium hydride In N,N-dimethyl-formamide Metallation; Stage #2: dibromodifluoromethane In N,N-dimethyl-formamide Alkylation;	69%
Stage #1: With sodium hydride In N,N-dimethyl-formamide for 1.5h; Stage #2: at 20℃; for 2h; Stage #3: dibromodifluoromethane; 4-chloro-4'-hydroxybenzophenone With potassium tert-butylate at 20℃; for 16h;

: 42019-78-3
4-chloro-4'-hydroxybenzophenone

: 814-68-6
acryloyl chloride

: (4-(acryloyloxy)phenyl)-(4-chlorophenyl)methanone

Conditions

Conditions	Yield
With sodium hydroxide; tetrabutyl-ammonium chloride In dichloromethane; water at 0 - 5℃;	68.8%

4-Chloro-4'-hydroxybenzophenone Chemical Properties

The Molecular Structure of 4-Chloro-4'-hydroxybenzophenone (CAS NO.42019-78-3):

Empirical Formula: C₁₃H₉ClO₂
Molecular Weight: 232.6624
IUPAC Name: (4-chlorophenyl)-(4-hydroxyphenyl)methanone
Appearance: light grey to beige-brown powder
Nominal Mass: 232 Da
Average Mass: 232.6624 Da
Monoisotopic Mass: 232.029107 Da
Index of Refraction: 1.623
Molar Refractivity: 62.82 cm³
Molar Volume: 177.9 cm³
Surface Tension: 51.9 dyne/cm
Density: 1.307 g/cm³
Flash Point: 198.1 °C
Enthalpy of Vaporization: 68.09 kJ/mol
Boiling Point: 404 °C at 760 mmHg
Vapour Pressure: 4.17E-07 mmHg at 25°C
Synonyms: 4-p-Chlorobenzoylphenol ; EINECS 255-627-4 ; 4-Chloro-4'-hydroxybenzophenone ; Methanone, (4-chlorophenyl)(4-hydroxyphenyl)-
Product Categories: FINE Chemical & INTERMEDIATES;Aromatic Benzophenones & Derivatives (substituted)

4-Chloro-4'-hydroxybenzophenone Safety Profile

Hazard Codes: Harmful Xn Irritant Xi
Risk Statements: 36/37/38-20/21/22
R36/37/38: Irritating to eyes, respiratory system and skin
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed
Safety Statements: 24/25-37/39-26-36
S24/25: Avoid contact with skin and eyes
S37/39: Wear suitable gloves and eye/face protection
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36: Wear suitable protective clothing
Hazard Note: Irritant

Product Name

4-Chloro-4'-hydroxybenzophenone

Synthetic route

4-Chloro-4'-hydroxybenzophenone Chemical Properties

4-Chloro-4'-hydroxybenzophenone Safety Profile

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