4-Ethoxyphenol supplier | CasNO.622-62-8

Name
4-Ethoxyphenol
EINECS 210-748-1
CAS No. 622-62-8
Article Data61
CAS DataBase
Density 1.076 g/cm³
Solubility slightly soluble in water
Melting Point 64-67 °C
Formula C₈H₁₀O₂
Boiling Point 246.393 °C at 760 mmHg
Molecular Weight 138.166
Flash Point 123.986 °C
Transport Information
Appearance beige crystalline powder or chunks
Safety 37/39-26-36
Risk Codes 41-37/38-22-36/37/38
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms Phenol,p-ethoxy- (6CI,7CI,8CI);Hydroquinoneethyl ether;Hydroquinone monoethyl ether;NSC 9885;p-Ethoxyphenol;p-Hydroxyphenetole;
PSA 29.46000
LogP 1.79090

Synthetic route

: 5076-72-2
1-ethoxy-4-methoxybenzene

: 622-62-8
4-Ethoxyphenol

Conditions

Conditions	Yield
With L-Selectride In tetrahydrofuran at 67℃; for 72h;	92%
With 1-methyl-pyrrolidin-2-one; potassium carbonate; 2-amino-benzenethiol for 0.25h; Heating;	90%

: 22237-13-4
(4-ethoxyphenyl)boronic acid

: 622-62-8
4-Ethoxyphenol

Conditions

Conditions	Yield
With dihydrogen peroxide In water at 20℃;	88%
With tert-butylammonium hexafluorophosphate(V); N,N'-dimethyl-4,4'-bipyridinium dihexafluorophosphate; triethylamine In N,N-dimethyl-formamide Electrochemical reaction;	68%

: 69697-44-5
4-ethoxyphenyl benzyl ether

: 622-62-8
4-Ethoxyphenol

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In ethanol at 20℃; under 760 Torr; Hydrogenolysis;	87%
With palladium 10% on activated carbon; ammonium formate In tetrahydrofuran; ethanol

: 75-03-6
ethyl iodide

: 123-31-9
hydroquinone

A: 622-62-8
4-Ethoxyphenol

B: 122-95-2
1,4-diethoxybenzene

Conditions

Conditions	Yield
With potassium carbonate In acetone for 70h; Heating;	A 11% B 83%

...Expand

: 64-17-5
ethanol

: 123-31-9
hydroquinone

: 622-62-8
4-Ethoxyphenol

Conditions

Conditions	Yield
With phosphomolybdic acid for 6h; Heating;	78%

: 563-43-9
ethylaluminum dichloride

: 106-51-4
p-benzoquinone

: 622-62-8
4-Ethoxyphenol

Conditions

Conditions	Yield
In hexane; dichloromethane -78 deg C, 1 h, then room temp., 2 h;	77%
In diethyl ether

: 64-17-5
ethanol

: 106-51-4
p-benzoquinone

: 622-62-8
4-Ethoxyphenol

Conditions

Conditions	Yield
With Amberlyst-15 for 4h; Reflux;	69%

: 123-31-9
hydroquinone

: 105-58-8
Diethyl carbonate

A: 622-62-8
4-Ethoxyphenol

B: 122-95-2
1,4-diethoxybenzene

Conditions

Conditions	Yield
With Magnesium-Aluminum layered double oxides catalyst at 149.84℃; under 760.051 Torr; for 12h; Autoclave; Inert atmosphere; Irradiation; Green chemistry;	A 60.5% B 15.7%

...Expand

: 106-51-4
p-benzoquinone

A: 622-62-8
4-Ethoxyphenol

B: 123-31-9
hydroquinone

Conditions

Conditions	Yield
With triethylaluminum In toluene at -78℃; for 2h;	A 8 % Spectr. B 56%

: 563-43-9
ethylaluminum dichloride

: 106-51-4
p-benzoquinone

A: 622-62-8
4-Ethoxyphenol

B: 123-31-9
hydroquinone

Conditions

Conditions	Yield
In toluene at -78℃; for 2h;	A 26 % Spectr. B 50%

...Expand

: 122-95-2
1,4-diethoxybenzene

: 622-62-8
4-Ethoxyphenol

Conditions

Conditions	Yield
With copper(I) oxide; sodium methylate In methanol at 185℃; for 12h; Autoclave;	45%

: 123-31-9
hydroquinone

C2H5-halide: C2H5-halide

: 622-62-8
4-Ethoxyphenol

Conditions

Conditions	Yield
Stage #1: hydroquinone With pyridine; poly(ethylene glycol) 4000; oxalyl dichloride In dichloromethane at 20℃; for 18h; Stage #2: C2H5-halide With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 18h; Stage #3: With sodium hydroxide at 20℃; for 2h;	33.7%

: 122-95-2
1,4-diethoxybenzene

A: 622-62-8
4-Ethoxyphenol

B: 123-31-9
hydroquinone

Conditions

Conditions	Yield
With copper(I) oxide; sodium methylate In methanol at 185℃; for 12h; Autoclave;	A 30% B 25%

: 64-17-5
ethanol

: 89713-14-4, 932-97-8
4-diazo-2,5-cyclohexadienone

: 622-62-8
4-Ethoxyphenol

Conditions

Conditions	Yield
beim Belichten.Irradiation;

: 89713-14-4, 932-97-8
4-diazo-2,5-cyclohexadienone

: 622-62-8
4-Ethoxyphenol

Conditions

Conditions	Yield
With ethanol Einwirkung von Licht;

: 38491-02-0
Diethyl-(4-ethoxy-phenyl)-phosphat

: 622-62-8
4-Ethoxyphenol

Conditions

Conditions	Yield
With potassium hydroxide

: 75631-63-9
trichloro-acetic acid-(4-ethoxy-phenyl ester)

: furan-2,3,5(4H)-trione pyridine (1:1)

: 622-62-8
4-Ethoxyphenol

: 64-67-5
diethyl sulfate

: 123-31-9
hydroquinone

: 622-62-8
4-Ethoxyphenol

Conditions

Conditions	Yield
With sodium hydroxide; nitrobenzene at 40℃;
With potassium hydroxide

: 123-31-9
hydroquinone

: 622-62-8
4-Ethoxyphenol

Conditions

Conditions	Yield
durch Aethylierung;

: 30008-10-7
sodium 4-hydroxybenzen-1-olate

: 80-40-0
ethyl ester of p-toluenesulfonic acid

A: 622-62-8
4-Ethoxyphenol

B: 122-95-2
1,4-diethoxybenzene

Conditions

Conditions	Yield
With methanol

...Expand

: 1988-78-9
4-(1-phenylethyl)phenetole

A: 622-62-8
4-Ethoxyphenol

B: 98-86-2
acetophenone

Conditions

Conditions	Yield
With oxygen at 120 - 140℃;

: 74-96-4
ethyl bromide

: 123-31-9
hydroquinone

: 622-62-8
4-Ethoxyphenol

: 106-41-2
4-bromo-phenol

: 141-52-6
sodium ethanolate

: 622-62-8
4-Ethoxyphenol

Conditions

Conditions	Yield
With 2,3,5-trimethyl-pyridine; copper(l) iodide Heating;

: 588-96-5
4-bromoethoxybenzene

: 622-62-8
4-Ethoxyphenol

Conditions

Conditions	Yield
(i) Li, (ii) B2H6, (iii) aq. NaOH, H2O2; Multistep reaction;

: 69217-37-4
4-ethoxy-2,4,6-tri-tertbutylcyclohexa-2,5-dienone

: 622-62-8
4-Ethoxyphenol

Conditions

Conditions	Yield
With aluminium trichloride; toluene In nitromethane

1-ethoxy-benzenediazonium sulfate-(4): 1-ethoxy-benzenediazonium sulfate-(4)

: 622-62-8
4-Ethoxyphenol

Conditions

Conditions	Yield
With sulfuric acid

: 7664-93-9
sulfuric acid

: O1-(4-ethoxy-phenyl)-ξ-D-glucopyranuronic acid

: 622-62-8
4-Ethoxyphenol

: 7647-01-0
hydrogenchloride

: (2-ethoxy-[1]naphthyl)-(4-ethoxy-phenyl)-diazene; dinitrate

A: 622-62-8
4-Ethoxyphenol

B: 622-61-7
1-chloro-4-ethoxybenzene

C: 117-17-9
2-ethoxy-1-nitronaphthalene

D: 3010-60-4
1-{4-ethoxy-benzeneazo}-2-naphthol

...Expand

: 4-ethoxy-benzenediazonium; hydrogen sulfate

aqueous sulfuric acid: aqueous sulfuric acid

: 622-62-8
4-Ethoxyphenol

: 622-62-8
4-Ethoxyphenol

: 106349-63-7
4-ethoxycyclohexan-1-ol

Conditions

Conditions	Yield
With nickel(II) oxide; hydrogen; palladium In hexane at 80℃; under 22502.3 Torr; for 10h;	99%
With hydrogen In water at 20℃; under 7500.75 Torr; for 8h; Autoclave;	94.8%
With ethanol; nickel at 200℃; under 102971 Torr; Hydrogenation;

: 40873-06-1
1,5-bis[p-chlorocarbonylphenoxy]pentane

: 622-62-8
4-Ethoxyphenol

: 102101-73-5
C35H36O8

Conditions

Conditions	Yield
With pyridine r.t., 2 h, 70 deg C, 2 h;	98%

: 622-62-8
4-Ethoxyphenol

: 106-51-4
p-benzoquinone

Conditions

Conditions	Yield
With Oxone; 4-iodophenoxyacetic acid In 2,2,2-trifluoroethanol; water at 20℃; for 0.5h;	97%
With bis-[(trifluoroacetoxy)iodo]benzene In water; acetonitrile for 0.166667h; Ambient temperature;	93%
With oxone; tetrabutylammomium bromide In water; acetonitrile at 20℃; for 1h;	92%
With Oxone In water; acetonitrile at 20℃; for 17h;	79%

: 32315-10-9
bis(trichloromethyl) carbonate

: 622-62-8
4-Ethoxyphenol

: 37782-55-1
4-(ethoxy)phenyl chloroformate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0℃; for 12h;	97%

: 622-62-8
4-Ethoxyphenol

: 302962-49-8
dasatanib

: dasatinib 4-ethoxyphenol co-crystal

Conditions

Conditions	Yield
In water at 50℃;	97%

: 1486-50-6
4-(benzyloxy)benzoic acid chloride

: 622-62-8
4-Ethoxyphenol

: 4-ethoxyphenyl 4-(benzyloxy) benzoate

Conditions

Conditions	Yield
With 4-pyrrolidin-1-ylpyridine; triethylamine In dichloromethane for 3h; Heating;	95%
With triethylamine In butanone at 0 - 20℃; for 3h;

: 622-62-8
4-Ethoxyphenol

: 604-69-3
β-D-glucose pentaacetate

: 50610-98-5
Acetic acid (2R,3R,4S,5R,6S)-3,5-diacetoxy-2-acetoxymethyl-6-(4-ethoxy-phenoxy)-tetrahydro-pyran-4-yl ester

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In benzene for 8h; Ambient temperature;	95%

: 622-62-8
4-Ethoxyphenol

polymer, Mn = 610, Mw/Mn = 1.6, unit ratio phenylene/oxyphenylene = 21/79; monomer(s): 4-ethoxyphenol: polymer, Mn = 610, Mw/Mn = 1.6, unit ratio phenylene/oxyphenylene = 21/79; monomer(s): 4-ethoxyphenol

Conditions

Conditions	Yield
With phosphate buffer; dihydrogen peroxide; horseradish peroxidase In isopropyl alcohol at 20℃; for 3h; pH=7;	94%

: 226396-63-0
1-(tert-butyl) 4-ethyl 4-[(4-fluorophenyl)sulfonyl]piperidine-1,4-dicarboxylate

: 622-62-8
4-Ethoxyphenol

: 226401-06-5
C27H35NO8S

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 24h;	94%

: 622-62-8
4-Ethoxyphenol

polymer, Mn = 650, Mw/Mn = 1.7, unit ratio phenylene/oxyphenylene = 15/85; monomer(s): 4-ethoxyphenol: polymer, Mn = 650, Mw/Mn = 1.7, unit ratio phenylene/oxyphenylene = 15/85; monomer(s): 4-ethoxyphenol

Conditions

Conditions	Yield
With phosphate buffer; dihydrogen peroxide; horseradish peroxidase In propan-1-ol at 20℃; for 3h; pH=7;	93%

: 622-62-8
4-Ethoxyphenol

: N-(3-bromophenethyl)-2-chloroacetamide

: N-(3-bromophenethyl)-2-(4-ethoxyphenoxy)acetamide

Conditions

Conditions	Yield
Stage #1: 4-Ethoxyphenol With caesium carbonate In acetonitrile for 2h; Stage #2: N-(3-bromophenethyl)-2-chloroacetamide In acetonitrile for 15h;	92%

: 622-62-8
4-Ethoxyphenol

: 106-96-7
propargyl bromide

: 5651-84-3
1-ethoxy-4-(prop-2-yn-1yloxy)benzene

Conditions

Conditions	Yield
With potassium carbonate In acetone; toluene for 8h; Heating;	91%

: 622-62-8
4-Ethoxyphenol

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 5076-72-2
1-ethoxy-4-methoxybenzene

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 140℃; for 1h; Microwave irradiation;	91%

: 16013-85-7
2,6-dicholoro-3-nitropyridine

: 622-62-8
4-Ethoxyphenol

: 1179106-41-2
C13H11ClN2O4

Conditions

Conditions	Yield
With potassium carbonate In tert-butyl alcohol at 20℃; for 12h;	91%

: 50-00-0
formaldehyd

: 622-62-8
4-Ethoxyphenol

: C10H14O4

Conditions

Conditions	Yield
Stage #1: formaldehyd; 4-Ethoxyphenol With sodium t-butanolate In water at 20℃; for 48h; Stage #2: With hydrogenchloride In dichloromethane; water pH=3;	91%

: 67-56-1
methanol

: 622-62-8
4-Ethoxyphenol

: 73010-52-3
4-ethoxy-4-methoxycyclohexa-2,5-dien-1-one

Conditions

Conditions	Yield
With potassium carbonate; bis-[(trifluoroacetoxy)iodo]benzene In acetonitrile for 0.166667h; Ambient temperature;	90%
With Ni0.64Al0.36(OH)2[(WO4)0.045(NO3)027]*0.6H2O; dihydrogen peroxide; ammonium bromide In water; ethyl acetate at 60℃;	92 % Chromat.
With [bis(acetoxy)iodo]benzene at 0 - 20℃; Inert atmosphere;

: 622-62-8
4-Ethoxyphenol

: 70856-65-4
4,4'-(decane-1,1'-diylbis(oxy))dibenzoic acid

: 102101-67-7
C40H46O8

Conditions

Conditions	Yield
With pyridine r.t., 2 h, 70 deg C, 2 h;	90%

: 622-62-8
4-Ethoxyphenol

: 105-45-3
acetoacetic acid methyl ester

: 4-methyl-6-ethoxy-2H-chromen-2-one

Conditions

Conditions	Yield
at 20℃; for 0.583333h; Sonication; Neat (no solvent);	90%

: 622-62-8
4-Ethoxyphenol

: 98-83-9
isopropenylbenzene

: 5-ethoxy-2-methyl-2-phenyl-2,3-dihydrobenzofuran

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone	90%
With 2,3-dicyano-5,6-dichloro-p-benzoquinone at 20℃; for 0.25h;	90%

: 622-62-8
4-Ethoxyphenol

: 14638-68-7
4,4′-hexylenedioxydibenzoyl chloride

: 102101-60-0
C36H38O8

Conditions

Conditions	Yield
With pyridine r.t., 2 h, 70 deg C, 2 h;	88%

: 622-62-8
4-Ethoxyphenol

: 1592-20-7
4-Vinylbenzyl chloride

: 1422547-43-0
C17H18O2

Conditions

Conditions	Yield
With tetrabutylammomium bromide; potassium carbonate In acetone Reflux; Inert atmosphere;	88%

: 622-62-8
4-Ethoxyphenol

: 105-36-2
ethyl bromoacetate

: 15267-81-9
ethyl 2-(4-ethoxyphenoxy)acetate

Conditions

Conditions	Yield
With potassium carbonate In acetone for 12h; Reflux;	88%

: 622-62-8
4-Ethoxyphenol

: 106-89-8
epichlorohydrin

: 18110-26-4
2-((4-ethyoxyphenoxy)methyl)oxirane

Conditions

Conditions	Yield
With potassium carbonate In acetone for 48h; Reflux; Inert atmosphere;	87%
With potassium carbonate In acetone Reflux;	83%
With potassium carbonate In acetone for 16h; Reflux;	83%

: (hydrotris(3,5-dimethyl-1-pyrazolyl)borate)oxomolybdenum(V)(Cl)2

: 622-62-8
4-Ethoxyphenol

: bis(para-ethoxy-phenolato hydrotris(3,5-dimethyl-1-pyrazolyl)borate)oxo molybdenum(V)

Conditions

Conditions	Yield
With triethylamine In benzene N2; exclusion of light; 70-75°C; 4-9 h;; filtered at room temp.; evapd.; dissolved in CH2Cl2; chromd. (SiO2, benzene/CH2Cl2); recrystd. from benzene; elem. anal.;;	87%
With triethylamine In toluene N2; exclusion of light; 70-75°C; 4-9 h;; filtered at room temp.; evapd.; dissolved in CH2Cl2; chromd. (SiO2, benzene/CH2Cl2); recrystd. from benzene; elem. anal.;;	87%

: 2417-72-3
Methyl 4-(bromomethyl)benzoate

: 622-62-8
4-Ethoxyphenol

: methyl 4-((4-ethoxyphenoxy)methyl)benzoate

Conditions

Conditions	Yield
With potassium carbonate In acetone for 48h; Reflux; Inert atmosphere;	87%

: 622-62-8
4-Ethoxyphenol

: 2-chloro-N-(3-(cyclopentyloxy)phenethyl)acetamide

: N-(3-(cyclopentyloxy)phenethyl)-2-(4-ethoxyphenoxy)acetamide

Conditions

Conditions	Yield
Stage #1: 4-Ethoxyphenol With caesium carbonate In acetonitrile for 2h; Stage #2: 2-chloro-N-(3-(cyclopentyloxy)phenethyl)acetamide In acetonitrile for 15h;	86%

: 622-62-8
4-Ethoxyphenol

: 2-fluoro-1-nitro-4-(prop-2-yn-1-yloxy)benzene

: 2-(4-ethoxyphenoxy)-1-nitro-4-(prop-2-yn-1-yloxy)benzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl acetamide at 160℃; for 2h; Inert atmosphere;	86%

4-Ethoxyphenol Chemical Properties

Product Name: 4-Ethoxyphenol (CAS NO.622-62-8)

Molecular Formula: C₈H₁₀O₂
Molecular Weight: 138.16g/mol
Mol File: 622-62-8.mol
EINECS: 210-748-1
Melting Point: 64-67 °C
Boiling point: 246.4 °C at 760 mmHg
Flash Point: 124 °C
Density: 1.076 g/cm³
Water Solubility: sightly soluble
Index of Refraction: 1.526
Molar Refractivity: 39.44 cm³
Molar Volume: 128.3 cm³
Surface Tension: 38 dyne/cm
Enthalpy of Vaporization: 50.31 kJ/mol
Vapour Pressure: 0.0173 mmHg at 25°C
XLogP3-AA: 1.8
H-Bond Donor: 1
H-Bond Acceptor: 2
Structure Descriptors of 4-Ethoxyphenol (CAS NO.622-62-8):
IUPAC Name: 4-ethoxyphenol
Canonical SMILES: CCOC1=CC=C(C=C1)O
InChI: InChI=1S/C8H10O2/c1-2-10-8-5-3-7(9)4-6-8/h3-6,9H,2H2,1H3
InChIKey: LKVFCSWBKOVHAH-UHFFFAOYSA-N
Product Categories: Liquid Crystal intermediates; Aromatic Phenols; Anthraquinones, Hydroquinones and Quinones; Phenetole; Building Blocks for Liquid Crystals; Functional Materials; Phenols (Building Blocks for Liquid Crystals)

4-Ethoxyphenol Uses

Intermediates of Liquid Crystals

4-Ethoxyphenol Toxicity Data With Reference

ipr-mus LDLo:250 mg/kg

RBPMAZ Revue Belge de Pathologie et de Medecine Experimentale. 22 (1952),1.

4-Ethoxyphenol Consensus Reports

Reported in EPA TSCA Inventory.

4-Ethoxyphenol Safety Profile

Poison by intraperitoneal route. Experimental reproductive effects. An irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes Xn Harmful ,Xi
Risk Statements 41-37/38-22-36/37/38
R41:Risk of serious damage to the eyes.
R37/38:Irritating to respiratory system and skin.
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements 37/39-26-36
S37/39:Wear suitable gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
RTECS SL3790000

4-Ethoxyphenol Specification

4-Ethoxyphenol , its CAS NO. is 622-62-8, the synonyms are Ether monoethylique de l'hydroquinone ; Hydroquinone monoethyl ether ; Phenol, 4-ethoxy- ; Phenol, p-ethoxy- ; p-Ethoxyphenol ; p-Hydroxyphenetole .

Product Name

4-Ethoxyphenol

Synthetic route

4-Ethoxyphenol Chemical Properties

4-Ethoxyphenol Uses

4-Ethoxyphenol Toxicity Data With Reference

4-Ethoxyphenol Consensus Reports

4-Ethoxyphenol Safety Profile

4-Ethoxyphenol Specification

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