4-Fluoro-3-phenoxybenzaldehyde supplier

Name
4-Fluoro-3-phenoxybenzaldehyde
EINECS 269-856-2
CAS No. 68359-57-9
Article Data6
CAS DataBase
Density 1.229 g/cm³
Solubility
Melting Point
Formula C₁₃H₉FO₂
Boiling Point 320 °C at 760 mmHg
Molecular Weight 216.212
Flash Point 142.5 °C
Transport Information UN 3082 9/PG 3
Appearance Light yellowish liquid.
Safety 61
Risk Codes 22-51/53
Molecular Structure
Hazard Symbols Xn; N
Synonyms 3-Phenoxy-4-fluorobenzaldehyde;4-Fluoro-3-phenoxybenzaldehyde;
PSA 26.30000
LogP 3.43050

Synthetic route

: 68359-37-5
cyfluthrin

A: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

B: 55701-05-8
3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide In methanol for 2h; Heating;

: 68359-55-7
4-fluoro-3-phenoxybenzyl bromide

: 108-03-2
1-Nitropropane

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

Conditions

Conditions	Yield
In ethanol

: 77771-05-2
4-fluoro-3-phenoxy-benzaldehyde ethyleneacetal

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water; toluene

: cis-α-cyano-3-phenoxy-4-fluoro-benzyl 2,2-dimethyl-3-(2-chloro-vinyl)cyclopropanecarboxylate

A: 541-47-9
3-Methylbutenoic acid

B: 60310-82-9
3-(2-chloro-vinyl)-2,2-dimethylcyclopropanecarboxylic acid

C: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

D: C8H11ClO

E: 76783-44-3
2-(4-fluoro-3-phenoxyphenyl)-2-hydroxyethanenitrile

F: 77279-89-1
4-fluoro-3-phenoxy benzoic acid

Conditions

Conditions	Yield
In hexane for 17h; UV-irradiation;

...Expand

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: 77279-89-1
4-fluoro-3-phenoxy benzoic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; acetic acid In ethanol for 4h; Heating;	100%
With potassium permanganate In water for 2h; Heating;	65%
With dihydrogen peroxide; acetic acid at 60 - 80℃; for 2h;

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: 68359-53-5
4-fluoro-3-phenoxyphenylmethanol

Conditions

Conditions	Yield
With formic acid; C20H29ClIrN4(1+)*Cl(1-) In ethanol; water at 80℃; for 0.25h; chemoselective reaction;	98%
With sodium hydroxide In diethyl ether; water
With sodium hydroxide In diethyl ether; water
With sodium hydroxide In diethyl ether; water

: potassium cyanide

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: C9H9Br2Cl2F3O

: C23H18Br2ClF4NO2

Conditions

Conditions	Yield
With tetrabutylammomium bromide In water; benzene at 15 - 20℃; for 10h;	95%

...Expand

: 773837-37-9
sodium cyanide

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: cis-2,2-dimethyl-3-(2-chloropropenyl)cyclopropanecarboxylic acid chloride

: cis-α-cyano-4-fluoro-3-phenoxybenzyl-2,2-dimethyl-3-(2-chloropropenyl)cyclopropanecarboxylate

Conditions

Conditions	Yield
With triethylamine In water; toluene at 20℃; for 4h;	95%

...Expand

: potassium cyanide

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: (1R)-trans-2,2-dimethyl-3-(2-chloropropenyl)cyclopropanecarboxylic acid chloride

: (1R)-trans-α-cyano-4-fluoro-3-phenoxybenzyl-2,2-dimethyl-3-(2-chloropropenyl)cyclopropanecarboxylate

Conditions

Conditions	Yield
With pyridine In cyclohexane; water at 20℃; for 4h;	93%

...Expand

: 17176-77-1
Dibenzyl phosphite

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: dibenzyl α-hydroxy(4-fluoro-3-phenoxy)benzylphosphonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 14h;	92%

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: 52314-67-7
permethric acid chloride

: 7757-82-6
sodium sulfate

: 68359-33-1
3'-phenoxy-4'-fluoro-benzyl 2,2-dimethyl-3-(2,2-dichlorovinyl)-cyclopropane-carboxylate

Conditions

Conditions	Yield
In water; ethyl acetate	91.5%

...Expand

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: 1384471-91-3
2-amino-N'-hydroxychroman-3-carboxamidine

: 1384471-90-2
N-(4-fluoro-3-phenoxybenzylidene)-3-(5-(4-fluoro-3-phenoxyphenyl)-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2H-chromen-2-amine

Conditions

Conditions	Yield
for 0.0833333h; Irradiation;	91%

: 773837-37-9
sodium cyanide

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: cis/trans-2,2-dimethyl-3-(2-chloropropenyl)cyclopropanecarboxylic acid chloride

: cis/trans-α-cyano-4-fluoro-3-phenoxybenzyl-2,2-dimethyl-3-(2-chloropropenyl)cyclopropanecarboxylate

Conditions

Conditions	Yield
With pyridine In cyclohexane; water at 20℃; for 4h;	91%

...Expand

: 5112-36-7
pyridine-2,6-dicarbohydrazide

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: N'2,N’6-bis [(4-fluoro-3-phenoxyphenyl)methylidene]pyridine-2,6-dicarbohydrazide

Conditions

Conditions	Yield
With acetic acid In ethanol Reflux;	89%

: 3156-37-4
4-bromo-β-nitrostyrene

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: 135-19-3
β-naphthol

: C31H19BrFNO2

Conditions

Conditions	Yield
With ammonium acetate; sodium hydroxide In water at 80℃; for 8h; Green chemistry;	87%

...Expand

: 292871-44-4
ethyl 4-[4-(methylthio)phenyl]-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: 79-11-8
chloroacetic acid

: CH3SC6H4C6HN2SOCH3CO2CH2CH3CHC6H3FOC6H5

Conditions

Conditions	Yield
With sodium acetate; acetic anhydride; acetic acid for 3h; Heating;	84%

...Expand

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: 1576-35-8
toluene-4-sulfonic acid hydrazide

: N'-[(4-fluoro-3-phenoxyphenyl)methylidene]-4-methylbenzenesulfonohydrazide

Conditions

Conditions	Yield
In ethanol Reflux;	84%

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: 588-05-6
m-tyramine

: C21H18FNO2

Conditions

Conditions	Yield
With acetic acid at 50℃; for 5h; Pictet-Spengler Synthesis; Molecular sieve; Inert atmosphere;	83%

: 27784-76-5
tert-butyl diethylphosphonoacetate

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: 1393363-56-8
tert-butyl (E)-3-(3'-phenoxy-4'-fluorophenyl)prop-2-enoate

Conditions

Conditions	Yield
Stage #1: tert-butyl diethylphosphonoacetate With methylmagnesium bromide In tetrahydrofuran; diethyl ether at 20℃; for 0.25h; Inert atmosphere; Stage #2: 4-fluoro-3-phenoxybenzaldehyde In tetrahydrofuran; diethyl ether for 15h; Horner-Wadsworth-Emmons olefination; Inert atmosphere; Reflux; optical yield given as %de; diastereoselective reaction;	82%

: 120-72-9
indole

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: C29H21FN2O

Conditions

Conditions	Yield
With sulfated anatase titania In neat (no solvent) at 20℃; for 0.5h; Green chemistry;	82%
With BiCl3-loaded montmorillonite K10 In neat (no solvent) at 20℃; for 0.666667h; Green chemistry;	82%

: 102-96-5
(2-nitroethenyl)benzene

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 108-59-8
malonic acid dimethyl ester

: 6-(4-fluoro-3-phenoxyphenyl)-5-nitro-4-phenylpiperidin-2-one

Conditions

Conditions	Yield
Stage #1: (2-nitroethenyl)benzene; malonic acid dimethyl ester With sodium hydroxide In methanol at 0℃; for 0.75h; Stage #2: 4-fluoro-3-phenoxybenzaldehyde; formamide In methanol Reflux;	78%

...Expand

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carbohydrazide

: (E)-2-(3-cyano-4-isobutoxyphenyl)-N’-(4-fluoro-3-phenoxybenzylidene)-4-methylthiazole-5-carbohydrazide

Conditions

Conditions	Yield
With acetic acid In ethanol for 8h; Reflux;	72%

: 1658-27-1
1,5-dioxaspiro[5.5]undecane-2,4-dione

: 102-96-5
(2-nitroethenyl)benzene

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: 2-aza-1,3-di(4-fluoro-3-phenoxyphenyl)-4-nitro5-phenyl-8,15-dioxa-7,16-dioxodispiro[5,2,59,26]hexadecane

Conditions

Conditions	Yield
Stage #1: 1,5-dioxaspiro[5.5]undecane-2,4-dione; (2-nitroethenyl)benzene With triethylamine In ethanol at 20℃; for 3h; Michael Addition; Stage #2: 4-fluoro-3-phenoxybenzaldehyde With ammonium acetate In ethanol at 45℃; for 20h; Mannich Aminomethylation;	71%

...Expand

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: 141-97-9
ethyl acetoacetate

: 109-77-3
malononitrile

: 6-amino-4-(4-fluoro-3-phenoxyphenyl)-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

Conditions

Conditions	Yield
With hydrazine hydrate; morpholine triflate In ethanol; water for 8h; Reflux; Green chemistry;	67%

...Expand

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: 5-amino-1-(2-hydroxy-2-phenylethyl)-1H-pyrazole-4-carbohydrazide

: (E)-5-amino-1-(2-hydroxy-2-phenylethyl)-N’-(4-fluoro-3-phenoxybenzylidene)-1H-pyrazole-4-carbohydrazide

Conditions

Conditions	Yield
In methanol; ethanol at 100℃; for 18h;	65%

: 3179-10-0
1-methoxy-4-(2-nitro-vinyl)-benzene

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 108-59-8
malonic acid dimethyl ester

: 6-(4-fluoro-3-phenoxyphenyl)-4-(4-methoxyphenyl)-5-nitropiperidin-2-one

Conditions

Conditions	Yield
Stage #1: 1-methoxy-4-(2-nitro-vinyl)-benzene; malonic acid dimethyl ester With sodium hydroxide In methanol at 0℃; for 0.75h; Stage #2: 4-fluoro-3-phenoxybenzaldehyde; formamide In methanol Reflux;	63%

...Expand

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: 1643-39-6
2-amino-4,6-di-tertbutylphenol

: 2,4-di-tert-butyl-6-{[(4-fluoro-3-phenoxyphenyl)methylene]amino}phenol

Conditions

Conditions	Yield
for 2h; Heating;	62%

: 3179-10-0
1-methoxy-4-(2-nitro-vinyl)-benzene

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: 504-02-9
1,3-cylohexanedione

: 2-(4-fluoro-3-phenoxybenzylideneamino)-3-(4-methoxyphenyl)benzofuran-4-ol

Conditions

Conditions	Yield
With piperidine; ammonium acetate In N,N-dimethyl-formamide at 20℃; for 7h; Michael Addition; Reflux;	61%

...Expand

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: 89765-17-3
3-(4-Ethoxyphenyl)-3-methyl-2-butanone

: 89765-18-4
1-(4-Fluoro-3-phenoxyphenyl)-4-(4-ethoxyphenyl)-4-methylpent-1-ene-3-one

Conditions

Conditions	Yield
With potassium hydroxide In ethanol at 20℃; for 6h; Condensation;	60%

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: 1530-32-1
ethyltriphenylphosphonium bromide

: (E)-1-fluoro-2-phenoxy-4-(prop-1-en-1-yl)benzene

Conditions

Conditions	Yield
With potassium carbonate In 1,4-dioxane at 110℃;	56.8%

: 2033-24-1
cycl-isopropylidene malonate

: 3179-10-0
1-methoxy-4-(2-nitro-vinyl)-benzene

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: 8-aza-7,9-di(4-fluoro-3-phenoxyphenyl)-11-(p-methoxyphenyl)-3,3-dimethyl-10-nitro-2,4-dioxa-1,5-dioxospiro[5,5]undecane

Conditions

Conditions	Yield
Stage #1: cycl-isopropylidene malonate; 1-methoxy-4-(2-nitro-vinyl)-benzene With triethylamine In ethanol at 20℃; for 3h; Michael Addition; Stage #2: 4-fluoro-3-phenoxybenzaldehyde With ammonium acetate In ethanol at 45℃; for 20h; Mannich Aminomethylation;	55%

...Expand

: 34040-62-5
o-(chloromethyl)benzoic acid methyl ester

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: 3-(4-fluoro-3-phenoxyphenyl)-3,4-dihydroisocoumarin

Conditions

Conditions	Yield
With N1,N1,N12,N12-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a:2,1'-c][1,4]diazepine-2,12-diamine In N,N-dimethyl-formamide at 20℃; for 16h; Glovebox; Inert atmosphere;	55%

: 3179-10-0, 5576-97-6
(E)-1-methoxy-4-(2-nitrovinyl)benzene

: 68359-57-9
4-fluoro-3-phenoxybenzaldehyde

: 108-59-8
malonic acid dimethyl ester

: C26H23FN2O7

Conditions

Conditions	Yield
Stage #1: (E)-1-methoxy-4-(2-nitrovinyl)benzene; malonic acid dimethyl ester With sodium hydroxide In methanol at 0℃; for 0.75h; Stage #2: 4-fluoro-3-phenoxybenzaldehyde With ammonium acetate In methanol at 20 - 85℃; for 40h;	53%

...Expand

4-Fluoro-3-phenoxybenzaldehyde Chemical Properties

IUPAC Name: 4-Fluoro-3-phenoxybenzaldehyde
Following is the structure of Benzaldehyde,4-fluoro-3-phenoxy- (CAS NO.68359-57-9):

Empirical Formula: C₁₃H₉FO₂
Molecular Weight: 216.2078
EINECS: 269-856-2
Index of Refraction: 1.591
Molar Refractivity: 59.44 cm³
Molar Volume: 175.8 cm³
Polarizability: 23.56 10^-24cm³
Surface Tension: 43 dyne/cm
Density: 1.229 g/cm³
Flash Point: 142.5 °C
Enthalpy of Vaporization: 56.16 kJ/mol
Boiling Point: 320 °C at 760 mmHg
Vapour Pressure: 0.000327 mmHg at 25 °C
Product Categories: Aromatic Aldehydes & Derivatives (substituted);Aldehydes;C10 to C21;Carbonyl Compounds
Canonical SMILES: C1=CC=C(C=C1)OC2=C(C=CC(=C2)C=O)F
InChI: InChI=1S/C13H9FO2/c14-12-7-6-10(9-15)8-13(12)16-11-4-2-1-3-5-11/h1-9H
InChIKey: JDICMOLUAHZVDS-UHFFFAOYSA-N

4-Fluoro-3-phenoxybenzaldehyde Safety Profile

Hazard Codes: Harmful Xn, Dangerous N
Risk Statements: 22-51/53
R22:Harmful if swallowed.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 61
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR UN: 3082 9/PG 3
WGK Germany: 2
Hazard Note: Harmful

4-Fluoro-3-phenoxybenzaldehyde Specification

Benzaldehyde,4-fluoro-3-phenoxy- , its cas register number 68359-57-9. It also can be called 3-(Phenoxy)-4-fluoro-benzaldehyde ; and 4-Fluoro-3-phenoxybenzaldehyde .

Product Name

4-Fluoro-3-phenoxybenzaldehyde

Synthetic route

4-Fluoro-3-phenoxybenzaldehyde Chemical Properties

4-Fluoro-3-phenoxybenzaldehyde Safety Profile

4-Fluoro-3-phenoxybenzaldehyde Specification

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