4-Methylpyridine supplier | CasNO.108-89-4

Name
4-Methylpyridine
EINECS 203-626-4
CAS No. 108-89-4
Article Data229
CAS DataBase
Density 0.95 g/cm³
Solubility Soluble in water
Melting Point 2.4 °C(lit.)
Formula C₆H₇N
Boiling Point 144.2 °C at 760 mmHg
Molecular Weight 93.1283
Flash Point 40 °C
Transport Information UN 1992 3/PG 3
Appearance colourless liquid
Safety 26-36-45
Risk Codes 10-20/22-24-36/37/38
Molecular Structure
Hazard Symbols T
Synonyms 4-Picoline(8CI);Ba 35846;NSC 18252;p-Methylpyridine;p-Picoline;g-Methylpyridine;g-Picoline;
PSA 12.89000
LogP 1.39000

Synthetic route

: 1003-67-4
4-methylpyridine-1-oxide

: 108-89-4
picoline

Conditions

Conditions	Yield
With methyloxorhenium(V)(2-(mercaptomethyl)thiophenolate) triphenylphosphine; tetrabutylammomium bromide; triphenylphosphine In water; benzene at 20℃; for 0.7h;	100%
With titanium In tetrahydrofuran for 0.25h; Ambient temperature;	98%
With titanium tetrachloride; tin(ll) chloride In benzene for 0.5h; Ambient temperature;	98%

: 7250-28-4
4-methyl-1-(2-oxo-2-phenylethyl)pyridinium bromide

A: 108-89-4
picoline

B: 98-86-2
acetophenone

Conditions

Conditions	Yield
With tetraethylammonium perchlorate In acetic acid; acetonitrile preparative electrolyse, - 1.33 V;	A 96% B 90%

: bromo(di-4-methylpyridine)(dicarbonyl)(phenylcarbyne)tungsten

: 119072-55-8, 7188-38-7
tert-butylisonitrile

A: 108-89-4
picoline

B: bromo(di-tert-butylisonitrile)(dicarbonyl)(phenylcarbyne)tungsten

Conditions

Conditions	Yield
In dichloromethane under N2 or Ar, refluxed for 3 h, solvent removed under HV; chromd. (silica gel, 0°C, CH2Cl2/Et2O (1/2)), solvent removed, pentane added; elem. anal., IR, NMR, mass spectra;	A n/a B 93%

...Expand

: 4-methyl-1,4-dihydropyridine

: 108-89-4
picoline

Conditions

Conditions	Yield
With dipotassium peroxodisulfate In acetonitrile for 1.5h; Heating;	92%

: 126963-91-5
benzyltri(2-(4-methylpyridyl))phosphonium bromide

A: 108-89-4
picoline

B: 366-18-7
[2,2]bipyridinyl

C: 1134-35-6
4,4'-dimethyl-2,2'-bipyridines

Conditions

Conditions	Yield
With hydrogenchloride In water for 0.5h; Product distribution; Ambient temperature; variation of pH, temp. and time;	A 17% B n/a C 84%

...Expand

: 126963-91-5
benzyltri(2-(4-methylpyridyl))phosphonium bromide

A: 108-89-4
picoline

B: 1134-35-6
4,4'-dimethyl-2,2'-bipyridines

C: C19H19N2OP

Conditions

Conditions	Yield
With hydrogenchloride In water for 0.5h; Ambient temperature;	A 17% B 84% C n/a

...Expand

: 6844-47-9
4-[(trimethylsilanyl)methyl]-pyridine

: 100-52-7
benzaldehyde

A: 108-89-4
picoline

B: 20151-37-5
1-phenyl-2-( pyridin-4-yl)ethanol

Conditions

Conditions	Yield
With hydrogenchloride; potassium fluoride; 18-crown-6 or silica-supported tetrabutylammonium fluoride In tetrahydrofuran at 20℃; for 12h; Yields of byproduct given;	A n/a B 80%

...Expand

: 15854-87-2
4-iodopyridine

: 31729-70-1
bis(iodozinc)methane

: 108-89-4
picoline

Conditions

Conditions	Yield
Stage #1: 4-iodopyridine; bis(iodozinc)methane With triphenylphosphine; nickel dichloride In tetrahydrofuran at 40℃; Stage #2: With hydrogenchloride In tetrahydrofuran; water Reagent/catalyst; chemoselective reaction;	74%

: 6844-47-9
4-[(trimethylsilanyl)methyl]-pyridine

: 100-39-0
benzyl bromide

A: 108-89-4
picoline

B: 2116-64-5
4-(2-phenylethyl)pyridine

Conditions

Conditions	Yield
With hydrogenchloride; potassium fluoride; 18-crown-6 or silica-supported tetrabutylammonium fluoride In tetrahydrofuran at 20℃; for 12h; Yields of byproduct given;	A n/a B 70%

...Expand

: {C6H6NCr(H2O)5}(2+)

A: 108-89-4
picoline

B: 4916-57-8
1,2-bis(4'-pyridyl)ethane

Conditions

Conditions	Yield
In perchloric acid addn. of Na2CO3;;	A 70% B 30%
With sodium carbonate byproducts: pyridine-4-aldehyde;	A 20% B n/a
With Na2CO3
In perchloric acid

: 13295-94-8
4-(phenylethynyl)pyridine

: 107-15-3
ethylenediamine

A: 108-89-4
picoline

B: 936-49-2
2-phenyl-2-imidazoline

Conditions

Conditions	Yield
In pyridine for 40h; Reflux;	A 27 %Chromat. B 70%

...Expand

: 1453-82-3
isonicotinamide

: 108-89-4
picoline

Conditions

Conditions	Yield
With samarium diiodide; phosphoric acid In tetrahydrofuran for 0.000833333h; Ambient temperature;	67%

: 122913-50-2
2,6-bis(methylthio)-4-methylpyridine

: 108-89-4
picoline

Conditions

Conditions	Yield
With nickel In ethanol for 3h; Ambient temperature;	65%

: 10445-91-7
4-(Chloromethyl)pyridine

: 100-52-7
benzaldehyde

A: 108-89-4
picoline

B: 20151-37-5
1-phenyl-2-( pyridin-4-yl)ethanol

Conditions

Conditions	Yield
With dipotassium hydrogenphosphate; silver nitrate; zinc In water at 30℃; for 1h;	A 48% B 64%

...Expand

: 75-07-0
acetaldehyde

A: 110-86-1
pyridine

B: 109-06-8
α-picoline

C: 108-89-4
picoline

Conditions

Conditions	Yield
With ammonia; Pb(5.3percent)/borotitano silicate at 420℃; for 1h; Product distribution / selectivity; Molecular sieve;	A 2.4% B 61.3% C 21.6%
With ammonia; Pb/SnS-1B at 395℃; Product distribution / selectivity;	A 1% B 53.4% C 22.3%
With ammonia; titanium-silicate catalyst (sample C) at 250 - 400℃; Conversion of starting material;	A 0.88% B 53.44% C 20.55%

...Expand

: 50-00-0
formaldehyd

: 75-07-0
acetaldehyde

A: 110-86-1
pyridine

B: 109-06-8
α-picoline

C: 108-89-4
picoline

D: 108-99-6
3-Methylpyridine

Conditions

Conditions	Yield
With Pb-ZSM-5 zeolite; ammonia In gas	A 60% B 7% C 4% D 8%
With Co-ZSM-5 zeolite; ammonia In gas	A 57% B 6% C 8% D 7%
With Ag-ZSM-5 zeolite; ammonia In gas	A 42% B 3% C 6% D 11%
With pentasil zeolite H-ZSM-5; ammonia In gas at 450℃; Product distribution; synthesis of pyridine bases over ion-exchanged pentasil zeolite; var. zeolites, var. Si/Al atomic ratio;	A 42% B 3% C 5% D 11%

...Expand

: 586-95-8
pyridine-4-methanol

: 108-89-4
picoline

Conditions

Conditions	Yield
With samarium diiodide; Trimethylacetic acid In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide at 20℃; for 0.166667h; Reduction;	60%
Multi-step reaction with 2 steps 1: benzene 2: palladium; methanol. NaOH-solution / Hydrogenation View Scheme

: 65350-59-6
N-butyl-4-methylpyridinium bromide

: 4984-82-1
sodium cyclopentadienylide

: 108-89-4
picoline

Conditions

Conditions	Yield
Stage #1: sodium cyclopentadienylide In tetrahydrofuran; N,N-dimethyl-formamide at 0℃; for 0.166667h; Inert atmosphere; Stage #2: N-butyl-4-methylpyridinium bromide In tetrahydrofuran; N,N-dimethyl-formamide at 20 - 190℃; for 4h; Inert atmosphere;	60%

: 1-o-Nitrobenzyl-4-methylpyridinium bromide

A: 108-89-4
picoline

B: 16968-19-7
2,2'-dinitrobibenzyl

C: 88-72-2
1-methyl-2-nitrobenzene

Conditions

Conditions	Yield
With tetraethylammonium perchlorate In acetonitrile preparative electrolyse, - 0.89 V;	A 52% B n/a C 18%

...Expand

: 1-o-Nitrobenzyl-4-methylpyridinium bromide

A: 108-89-4
picoline

B: 88-72-2
1-methyl-2-nitrobenzene

Conditions

Conditions	Yield
With tetraethylammonium perchlorate In acetonitrile at 20℃; Rate constant; electrolyse, -0.89 V;	A 52% B 18%

: {C6H6NCr(H2O)5}(2+)

A: 108-89-4
picoline

B: 69046-49-7
4-{α-D1}-methylpyridine

Conditions

Conditions	Yield
With water-d2 In water-d2	A 50% B n/a
With D2O In water-d2

: 55-22-1
pyridine-4-carboxylic acid

: 108-89-4
picoline

Conditions

Conditions	Yield
With samarium diiodide; phosphoric acid In tetrahydrofuran for 0.000833333h; Ambient temperature;	48%
With sulfuric acid elektrochemische Reduktion;
With sulfuric acid elektrochemische Reduktion;
With acetic acid; zinc

: 1003-67-4
4-methylpyridine-1-oxide

: 16420-13-6
N,N-Dimethylthiocarbamoyl chloride

A: 108-89-4
picoline

B: C9H12N2OS

C: C9H12N2OS

Conditions

Conditions	Yield
In acetonitrile at 81℃; for 4h;	A 39% B 3% C 4%

...Expand

: 1003-67-4
4-methylpyridine-1-oxide

: 123-39-7
N-Methylformamide

A: 108-89-4
picoline

B: 107427-71-4
N,4-dimethylpyridine-2-carboxamide

Conditions

Conditions	Yield
for 32h; Heating;	A n/a B 38%

...Expand

: 57042-61-2
4-methyl-N-(4-nitrobenzyl)pyridinium bromide

A: 108-89-4
picoline

B: 99-99-0
1-methyl-4-nitrobenzene

Conditions

Conditions	Yield
With tetraethylammonium perchlorate In acetonitrile preparative electrolyse, - 0.99 V;	A 38% B 35%
With tetraethylammonium perchlorate In acetonitrile electrolysis reaction;	A 38% B 35%
With tetraethylammonium perchlorate In acetonitrile at 20℃; Rate constant; electrolyse, -0.99 V;	A 38% B 35%

: 108-47-4
2,4-lutidine

: 108-89-4
picoline

Conditions

Conditions	Yield
nickel(II) nitrate In methanol for 24h; Product distribution; Irradiation;	37%

: 1453-82-3
isonicotinamide

A: 108-89-4
picoline

B: 626-58-4
4-methylpiperidin

Conditions

Conditions	Yield
With hydrogenchloride; samarium for 0.166667h; Ambient temperature;	A 21% B 37%

: 108-89-4
picoline

: 109-65-9
1-bromo-butane

: 65350-59-6
N-butyl-4-methylpyridinium bromide

Conditions

Conditions	Yield
Darkness;	100%
Darkness;	100%
In ethanol for 24h; Reflux;	100%

: 108-89-4
picoline

: 74-96-4
ethyl bromide

: 32353-49-4
1-ethyl-4-methylpyridin-1-ium bromide

Conditions

Conditions	Yield
Darkness;	100%
Darkness;	100%

: 108-89-4
picoline

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 57042-61-2
4-methyl-N-(4-nitrobenzyl)pyridinium bromide

Conditions

Conditions	Yield
In acetone; benzene at 20℃; for 24h;	100%
In dichloromethane at 20℃; for 2h;	46%

: 108-89-4
picoline

: 74-88-4
methyl iodide

: 2301-80-6
N-methyl-4-methylpyridinium iodide

Conditions

Conditions	Yield
In diethyl ether at 20℃; for 120h; Methylation;	100%
In acetone for 2h; Reflux;	100%
In methanol at 90℃; for 12h; Inert atmosphere;	97%

: 108-89-4
picoline

: 100-48-1
pyridine-4-carbonitrile

Conditions

Conditions	Yield
With ammonia; oxygen; V4Ti4Sn*xO at 375℃; var. temp.; influence of water additions and heat-treatment temperature of catalyst; also 2-picoline;	100%
With ammonia; oxygen; V4Ti4Sn*xO at 375 - 390℃;	100%
	100%

: 108-89-4
picoline

: 451-46-7
4-fluorobenzoic acid ethyl ester

: 6576-05-2
1-(4-fluorophenyl)-2-(4-pyridyl)ethanone

Conditions

Conditions	Yield
With sodium hexamethyldisilazane In tetrahydrofuran	100%
Stage #1: picoline With lithium hexamethyldisilazane In tetrahydrofuran at 0℃; for 1h; Inert atmosphere; Stage #2: 4-fluorobenzoic acid ethyl ester In tetrahydrofuran at 0 - 20℃; for 2.75h;	95%
With lithium hexamethyldisilazane In tetrahydrofuran at 0 - 25℃; flow microreactor;	94%

: 108-89-4
picoline

: 100-39-0
benzyl bromide

: 57042-58-7
1-benzyl-1-bromo-4-methylpyridinium bromide

Conditions

Conditions	Yield
	100%
In acetonitrile at 45℃; for 3h;	99%
In acetonitrile at 100℃; for 12h;	98.71%

: 108-89-4
picoline

: 111-83-1
1-bromo-octane

: 1-(n-octyl)-4-methylpyridinium bromide

Conditions

Conditions	Yield
Darkness;	100%
Darkness;	100%
In acetonitrile at 70℃;	97%

: 108-89-4
picoline

: 638-07-3
ethyl (2-chloroaceto)acetate

: 1-ethoxycarbonylacetonyl-4-methylpyridinium chloride

Conditions

Conditions	Yield
at 20℃; for 24h;	100%

: 108-89-4
picoline

: 1523-15-5
2,4-dinitrophenyl benzoate

: C19H15N3O6

Conditions

Conditions	Yield
In water; dimethyl sulfoxide at 25℃; Kinetics;	100%

: 108-89-4
picoline

: 4286-55-9
1-bromo-6-hexanol

: N-(6-hydroxyhexyl)-4-picolinium bromide

Conditions

Conditions	Yield
In ethanol for 36h; Heating / reflux;	100%

: 108-89-4
picoline

: 7646-78-8
tin(IV) chloride

: [SnCl4(γ-picoline)2]

Conditions

Conditions	Yield
In tetrachloromethane under N2; soln. of SnCl4 in CCl4 mixed with ligand (molar ratio 1:2); stirred for several h; filtered; solid washed with petroleum ether; dried in vac.; stored in desiccator over CaCl2; elem. anal.;	100%

: 108-89-4
picoline

: (η5-pentamethylcyclopentadienyl)rhodium tris(acetonitrile) tetrafluoroborate

: {(C5(CH3)5)Rh(C5H4(CH3)N)3}(2+)*2BF4(1-) = {(C5(CH3)5)Rh(C5H4(CH3)N)3}(BF4)2

Conditions

Conditions	Yield
In dichloromethane (Ar), stirred for 15 min; filtered, solvent reduced, Et2O added, solid washed with Et2O, recrystd. from CH2Cl2/Et2O at -30°C, elem. anal.;	100%

: 108-89-4
picoline

: (C10H7NC(CH3)C6H4)2Pd2Cl2

: (C10H7NC(CH3)C6H4PdCl(C5H4NCH3))*CH2Cl2

Conditions

Conditions	Yield
In dichloromethane add. of excess of methylpyridine to Pd-compound in CH2Cl2; filtration on a Celite column (4cm), evaporation, washing with pentane, elem. anal.;	100%

: 108-89-4
picoline

: {(((CH3O)3Si)(CO)3Fe((C6H5)2PC5H4N)CdBr)2}

: Fe(CO)3(Si(OCH3)3)(P(C6H5)2(C5H4N))CdBr(C5H4(CH3)N)

Conditions

Conditions	Yield
In dichloromethane (N2), 4-picoline added to a soln. of the FeCd-complex, stirred for 5 min; solvent removed, dried in vacuo for several hours, elem. anal.;	100%

: 108-89-4
picoline

: 77514-81-9
[PdC5H5NC5H3N(CH2C(CO2C2H5)2)2]

: 74468-77-2
[Pd(C5H3NCH2C(CO2C2H5)2)2]

Conditions

Conditions	Yield
In dichloromethane stirred soln. of complex and γ-picoline in CH2Cl2 at 25°C for 12 h, removed the solvent in vac.; chromy., elem. anal.;	100%

: 108-89-4
picoline

: Fe(2+)*(C5H4B(CH3)2)2(C10H8N2)(2-)=((C5H4B(CH3)2)2(C10H8N2))Fe

: 215434-76-7
(C5H4B(CH3)2(C6H7N))2Fe

Conditions

Conditions	Yield
In dichloromethane byproducts: 4,4'-bipyridine; Ar atmosphere;	100%

: 108-89-4
picoline

: Fe(2+)*(C5H4B(CH3)2)2(C12H12N2)(2-)=((C5H4B(CH3)2)2(C12H12N2))Fe

: 215434-76-7
(C5H4B(CH3)2(C6H7N))2Fe

Conditions

Conditions	Yield
In not given byproducts: 1,2-bis(4-pyridyl)ethane; Ar atmosphere;	100%

: 108-89-4
picoline

: palladium dichloride

: 67528-42-1, 21256-09-7
trans-dichlorobis(γ-picoline)palladium(II)

Conditions

Conditions	Yield
In acetonitrile dissoln. of Pd-compd. under reflux (1-2 h), ligand addn.; cooling, ppt. filtration off, washing (ethanol), drying; elem. anal.;	100%
In acetonitrile (Ar), room temp., 24 h;
In acetonitrile at 20℃; for 24h; Inert atmosphere;
In acetonitrile at 20℃; for 24h; Inert atmosphere;

: 108-89-4
picoline

: 345298-30-8
di-μ-chloro-dichloro-bis[η5-(perfluorobutyl)tetramethylcyclopentadienyl]-dirhodium(III)

: 933802-67-6
dichloro-(perfluorohexyl)tetramethylcyclopentadienyl-(4-methylpyridine)-rhodium(III)

Conditions

Conditions	Yield
In chloroform (Ar); methylpyridine was added to soln. of Rh complex in CHCl3; mixt. was stirred for 2 h at room temp.; evapd.; dried (vac.); elem. anal.;	100%

: 108-89-4
picoline

: 110-53-2
1-Bromopentane

: 27876-24-0
4-hexylpyridine

Conditions

Conditions	Yield
Stage #1: picoline With lithium diisopropyl amide In tetrahydrofuran; n-heptane; ethylbenzene at -78℃; for 0.5h; Inert atmosphere; Stage #2: 1-Bromopentane In tetrahydrofuran; n-heptane; ethylbenzene at 20℃; for 20h;	100%

: 108-89-4
picoline

: copper(l) cyanide

: 4-methylpyridine copper(I) cyanide complex

Conditions

Conditions	Yield
In further solvent(s) suspn. of CuCN in 4MePy heated in sealed tube under Ar to 70°C overnight, cooled; ppt. filtered off, washed with Et2O, air dried for 15 min; elem. anal.;	100%

: 108-89-4
picoline

: 627-32-7
1-iodopropan-3-ol

: 1-(3-hydroxypropyl)-4-methylpyridin-1-ium iodide

Conditions

Conditions	Yield
In 1,4-dioxane at 101℃; for 16h; Inert atmosphere;	100%

: 108-89-4
picoline

: Ti10O12(catecholato)8(pyridine)8

: Ti10O12(catecholato)8(4-picoline)8

Conditions

Conditions	Yield
In chloroform	100%

: 108-89-4
picoline

: 25542-62-5
6-bromo-hexanoic acid ethyl ester

: 1-(6-ethoxy-6-oxohexyl)-4-methylpyridinium bromide

Conditions

Conditions	Yield
In acetonitrile at 90℃; Reflux;	100%

: 108-89-4
picoline

: 1207958-19-7
C12H15NO

: N,N-dimethyl-4-(pyridin-4-yl)-3-(o-tolyl)butanamide

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium hexamethylsilazane In tetrahydrofuran at 0℃; for 3h; Inert atmosphere;	100%

: 108-89-4
picoline

: 21469-80-7
C11H12FNO

: 3-(4-fluorophenyl)-N,N-dimethyl-4-(pyridin-4-yl)butanamide

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium hexamethylsilazane In tetrahydrofuran at 0℃; for 3h; Inert atmosphere;	100%

: 108-89-4
picoline

: C36H54N4Zn2

: C48H68N6Zn2

Conditions

Conditions	Yield
In toluene at 20℃; for 2h; Inert atmosphere; Schlenk technique;	100%

: 108-89-4
picoline

: 64443-05-6
tetrakis(actonitrile)copper(I) hexafluorophosphate

: 192226-54-3
2,9-dimesityl-[1,10]-phenanthroline

: C30H28N2*Cu(1+)*C6H7N

Conditions

Conditions	Yield
In dichloromethane-d2 for 0.0333333h; Sonication;	100%

...Expand

4-Methylpyridine Consensus Reports

Reported in EPA TSCA Inventory.

4-Methylpyridine Specification

The 4-Methylpyridine, with the CAS registry number 108-89-4, is also known as p-Methylpyridine. It belongs to the product category of Pyridines Derivates. Its EINECS registry number is 203-626-4. This chemical's molecular formula is C₆H₇N and molecular weight is 93.13. Its IUPAC name is called 4-methylpyridine. This chemical's classification code is Skin / Eye Irritant.

Physical properties of 4-Methylpyridine: (1)ACD/LogP: 1.33; (2)ACD/LogD (pH 5.5): 0.756; (3)ACD/LogD (pH 7.4): 1.315; (4)ACD/BCF (pH 5.5): 1.61; (5)ACD/BCF (pH 7.4): 5.831; (6)ACD/KOC (pH 5.5): 33.622; (7)ACD/KOC (pH 7.4): 121.758; (8)#H bond acceptors: 1; (9)Index of Refraction: 1.501; (10)Molar Refractivity: 29.169 cm³; (11)Molar Volume: 98.932 cm³; (12)Surface Tension: 34.098 dyne/cm; (13)Density: 0.941 g/cm³; (14)Flash Point: 56.667 °C; (15)Enthalpy of Vaporization: 37.51 kJ/mol; (16)Boiling Point: 144.24 °C at 760 mmHg; (17)Vapour Pressure: 6.465 mmHg at 25°C.

Preparation of 4-Methylpyridine: this chemical can be prepared by acetaldehyde and ammonia. At last, you should collect 142-144 °C fractions. The yield is about 20%.

3CH₃CHO+NH₃→C₆H₇N+3H₂O+H₂↑

Uses of 4-Methylpyridine: it can be used in the production of drugs isoniazid, alexipharmac
obidoxime chloride and trimedoximum. Meanwhile, it is also used in the production of pesticide; dyes; rubber additives and synthetic resin. 4-Methylpyridine can also be used for the preparation of different tobacco acid, different tobacco hydrazine, pesticides, synthetic resin, rubber vulcanization promoting agents, etc. What's more, this chemical can also be used as a solvent.

When you are using this chemical, please be cautious about it as the following:
This chemical is toxic. It is harmful by inhalation and if swallowed. In addition, it is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CC1=CC=NC=C1
(2)InChI: InChI=1S/C6H7N/c1-6-2-4-7-5-3-6/h2-5H,1H3
(3)InChIKey: FKNQCJSGGFJEIZ-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - wild	LD50	oral	422mg/kg (422mg/kg)		Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
guinea pig	LDLo	skin	500mg/kg (500mg/kg)		"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 841, 1986.
mouse	LC50	inhalation	4gm/m³(4000mg/m³)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 57(9-10), Pg. 64, 1992.
mouse	LD50	intraperitoneal	335mg/kg (335mg/kg)		Toxicon. Vol. 23, Pg. 815, 1985.
mouse	LD50	oral	350mg/kg (350mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 57(9-10), Pg. 64, 1992.
rabbit	LD50	skin	270uL/kg (0.27mL/kg)		AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 10, Pg. 61, 1954.
rat	LCLo	inhalation	1000ppm/4H (1000ppm)		AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 10, Pg. 61, 1954.
rat	LD50	intraperitoneal	163mg/kg (163mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Fundamental and Applied Toxicology. Vol. 5, Pg. 920, 1985.
rat	LD50	oral	440mg/kg (440mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 57(9-10), Pg. 64, 1992.

Product Name

4-Methylpyridine

Synthetic route

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