5-Aminosalicylic acid supplier

Name
5-Aminosalicylic acid
EINECS 201-919-1
CAS No. 89-57-6
Article Data80
CAS DataBase
Density 1.491 g/cm³
Solubility <0.1 g/100 mL at 21 °C in water
Melting Point 275-280 °C (dec.)(lit.)
Formula C₇H₇NO₃
Boiling Point 403.9 °C at 760 mmHg
Molecular Weight 153.137
Flash Point 198.1 °C
Transport Information
Appearance Off-white crystals
Safety 26-36-24/25
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Benzoic acid, 5-amino-2-hydroxy-;Asacol (TN);Benzoic acid, 5-amino-2-hydroxy-, hydrochloride;Pentasa (TN);Rowasa;Canasa;5-amino-2-hydroxy-benzoate;Mesalazine (JAN);5-amino-2-hydroxy-benzoic acid hydrochloride;Salofalk;Asacol;Mesalamine [USAN];Mesalazine;p-Aminosalicylsaeure [German];sodium 5-amino-2-hydroxy-benzoate;5-Amino Salicylic Acid;Mesalamine;Claversal;4-14-00-02058 (Beilstein Handbook Reference);5-amino-2-hydroxy-benzoic acid;Pentasa;Mesalazina [Spanish];Mesalamine (USP);Benzoic acid,5-amino-2-hydroxy-;Mesalazinum [Latin];Rowasa (TN);m-Aminosalicylic acid;Sodium 5-aminosalicylate;5-Aminosalicyclic Acid;Mesalazine5-Aminosalicylic acid;5-Aminosalicylic acid (Mesalazine);Malasazine;2-Hydroxy-5-aminobenzoic acid;Masalazine;
PSA 83.55000
LogP 1.25380

Synthetic route

: 96-97-9
5-nitrosalicylic acid

: 89-57-6
5-Aminosalicylic Acid

Conditions

Conditions	Yield
Stage #1: 5-nitrosalicylic acid at 95 - 98℃; pH=2; Stage #2: With sodium hydroxide at 85 - 95℃; for 2.5h; pH=11.5 - 12; Product distribution / selectivity;	91.6%
With G-CAT; R-CAT In water at 95 - 98℃; Product distribution / selectivity;	91.6%
With hydrogenchloride; zinc In water for 4h; Reflux;	88%

: 124-38-9
carbon dioxide

: 123-30-8
4-amino-phenol

: 89-57-6
5-Aminosalicylic Acid

Conditions

Conditions	Yield
Stage #1: 4-amino-phenol With sodium hydroxide at 130 - 150℃; Kolbe-Schmitt reaction; Stage #2: carbon dioxide under 67506.8 Torr; Kolbe-Schmitt reaction; Autoclave; Heating; Stage #3: With sulfuric acid pH=2 - 3; Kolbe-Schmitt reaction;	90.5%
Stage #1: carbon dioxide; 4-amino-phenol With sodium carbonate; sodium chloride at 200℃; under 7500.75 Torr; for 6h; Kolbe-Schmidt Synthesis; Autoclave; Stage #2: With hydrogenchloride In water pH=1 - 6; Reagent/catalyst; Temperature; Pressure;	90%
In tetrahydrofuran for 8h; Quantum yield; UV-irradiation; Schlenk technique;	34 %Spectr.

: 124-38-9
carbon dioxide

: 103-90-2
4-acetaminophenol

: 89-57-6
5-Aminosalicylic Acid

Conditions

Conditions	Yield
Stage #1: carbon dioxide; 4-acetaminophenol With potassium hydroxide at 220℃; under 37503.8 Torr; for 1h; Stage #2: With hydrogenchloride; water at 80℃; pH=4; Reagent/catalyst; Temperature; Pressure; Time;	90%

: 5-(4'-sulphophenylazo)salicylic acid sodium salt

: 89-57-6
5-Aminosalicylic Acid

Conditions

Conditions	Yield
With sodium hydroxide; sodium dithionite In water for 0.00555556h; microwave irradiation;	71%

: 21460-89-9
2-hydroxy-5-phenylazobenzoic acid methyl ester

: 89-57-6
5-Aminosalicylic Acid

Conditions

Conditions	Yield
With hydrogenchloride; tin
With phenylhydrazine at 100 - 120℃;

: 96-97-9
5-nitrosalicylic acid

A: 89-57-6
5-Aminosalicylic Acid

B: 51-59-2
N-Acetyl-5-aminosalicylic acid

Conditions

Conditions	Yield
With tin; acetic acid dann verduennt man mit Wasser und faellt mit Schwefelwasserstoff;
With tin; acetic acid

: 51-78-5
p-aminophenol hydrochloride

: 15719-64-9, 15719-76-3, 97762-63-5
methylammonium carbonate

: 89-57-6
5-Aminosalicylic Acid

Conditions

Conditions	Yield
With potassium carbonate at 200℃; under 36775.4 Torr;

: 21460-89-9
2-hydroxy-5-phenylazobenzoic acid methyl ester

: 100-63-0
phenylhydrazine

: 89-57-6
5-Aminosalicylic Acid

Conditions

Conditions	Yield
at 100 - 120℃;

: 21460-90-2
2-hydroxy-5-phenylazo-benzoic acid ethyl ester

: 100-63-0
phenylhydrazine

: 89-57-6
5-Aminosalicylic Acid

Conditions

Conditions	Yield
at 100 - 120℃;

: 100-63-0
phenylhydrazine

: 3147-53-3
2-hydroxy-5-phenylazo-benzoic acid

A: 89-57-6
5-Aminosalicylic Acid

B: 62-53-3
aniline

...Expand

: 121-92-6
3-nitrobenzoic acid

: 89-57-6
5-Aminosalicylic Acid

Conditions

Conditions	Yield
With sulfuric acid Electrolysis;
With sulfuric acid; platinum at 115 - 145℃; under 25742.8 Torr; Hydrogenation;
With sulfuric acid; zinc at 50 - 80℃;

: 64-17-5
ethanol

: 6283-26-7
2-hydroxy-5-(3-nitro-phenylazo)-benzoic acid

A: 89-57-6
5-Aminosalicylic Acid

B: 21371-44-8, 140661-36-5
3,3'-diaminoazobenzene

Conditions

Conditions	Yield
With potassium hydroxide; zinc

...Expand

: 3147-53-3
2-hydroxy-5-phenylazo-benzoic acid

: 89-57-6
5-Aminosalicylic Acid

Conditions

Conditions	Yield
With phenylhydrazine
With sodium hydroxide; zinc
With sulfuric acid bei der elektrolytischen Reduktion;

: 7664-93-9
sulfuric acid

: 121-92-6
3-nitrobenzoic acid

platinum: platinum

: 89-57-6
5-Aminosalicylic Acid

Conditions

Conditions	Yield
at 115 - 145℃; under 35 - 22065.2 Torr; Hydrogenation;

...Expand

: 64-17-5
ethanol

: 6283-26-7
2-hydroxy-5-(3-nitro-phenylazo)-benzoic acid

zinc: zinc

KOH-solution: KOH-solution

A: 89-57-6
5-Aminosalicylic Acid

B: 21371-44-8, 140661-36-5
3,3'-diaminoazobenzene

...Expand

: 6283-26-7
2-hydroxy-5-(3-nitro-phenylazo)-benzoic acid

hydrosulfite sodium: hydrosulfite sodium

A: 89-57-6
5-Aminosalicylic Acid

B: 108-45-2
m-phenylenediamine

...Expand

: 7647-01-0
hydrogenchloride

: 6283-26-7
2-hydroxy-5-(3-nitro-phenylazo)-benzoic acid

tin dichloride: tin dichloride

A: 89-57-6
5-Aminosalicylic Acid

B: 108-45-2
m-phenylenediamine

...Expand

: 7664-93-9
sulfuric acid

: 3147-53-3
2-hydroxy-5-phenylazo-benzoic acid

: 89-57-6
5-Aminosalicylic Acid

Conditions

Conditions	Yield
durch elektrolytische Reduktion;

: 7647-01-0
hydrogenchloride

: 3147-53-3
2-hydroxy-5-phenylazo-benzoic acid

titanium (III)-chloride: titanium (III)-chloride

: 89-57-6
5-Aminosalicylic Acid

...Expand

: 3147-53-3
2-hydroxy-5-phenylazo-benzoic acid

hydrosulfite sodium: hydrosulfite sodium

A: 89-57-6
5-Aminosalicylic Acid

B: 62-53-3
aniline

...Expand

: 7647-01-0
hydrogenchloride

: 3147-53-3
2-hydroxy-5-phenylazo-benzoic acid

tin dichloride: tin dichloride

A: 89-57-6
5-Aminosalicylic Acid

B: 62-53-3
aniline

...Expand

: furan-2,3,5(4H)-trione pyridine (1:1)

: 3147-53-3
2-hydroxy-5-phenylazo-benzoic acid

zinc: zinc

A: 89-57-6
5-Aminosalicylic Acid

B: 62-53-3
aniline

...Expand

: 2243-76-7
alizarin yellow R

Na2S2O4: Na2S2O4

A: 89-57-6
5-Aminosalicylic Acid

B: 106-50-3
1,4-phenylenediamine

Conditions

Conditions	Yield
in alkal.Loesung;

...Expand

: 7647-01-0
hydrogenchloride

: 21460-89-9
2-hydroxy-5-phenylazobenzoic acid methyl ester

tin: tin

: 89-57-6
5-Aminosalicylic Acid

...Expand

: 7647-01-0
hydrogenchloride

: 21460-90-2
2-hydroxy-5-phenylazo-benzoic acid ethyl ester

tin: tin

: 89-57-6
5-Aminosalicylic Acid

...Expand

: 21542-82-5
4-[(3-carboxyl-4-hydroxy)phenylazo]benzenesulfonic acid

tin dichloride hydrochloride: tin dichloride hydrochloride

A: 89-57-6
5-Aminosalicylic Acid

B: 121-57-3
4-aminobenzene sulfonic acid

...Expand

: 7647-01-0
hydrogenchloride

: 13252-72-7
acide 3-hydroxylaminobenzoique

: 89-57-6
5-Aminosalicylic Acid

3-nitro-benzoate sodium: 3-nitro-benzoate sodium

: 89-57-6
5-Aminosalicylic Acid

Conditions

Conditions	Yield
With sodium hydrogensulfide; hydrogen sulfide at 25℃; nachfolgend Umlagerung durch Eindampfen mit Salzsaeure;

5-nitroso-salicylic acid: 5-nitroso-salicylic acid

: 89-57-6
5-Aminosalicylic Acid

Conditions

Conditions	Yield
With hydrogenchloride; tin
With sodium dithionite

: 24424-99-5
di-tert-butyl dicarbonate

: 89-57-6
5-Aminosalicylic Acid

: 135321-95-8
2-hydroxy-5-<(tert-butoxycarbonyl)amino>benzoic acid

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane; water at 0 - 20℃; for 16.5h;	100%
Stage #1: di-tert-butyl dicarbonate; 5-Aminosalicylic Acid With triethylamine In 1,4-dioxane; water at 0 - 20℃; for 16.5h; Stage #2: With hydrogenchloride In water at 0℃;	100%
With triethylamine In 1,4-dioxane; water for 3h; Ambient temperature;	97%

: 75-15-0
carbon disulfide

: 89-57-6
5-Aminosalicylic Acid

: 116569-31-4
5-isothiocyanatosalicylic acid

Conditions

Conditions	Yield
Stage #1: carbon disulfide; 5-Aminosalicylic Acid With triethylamine In tetrahydrofuran; water at 20℃; for 17h; Stage #2: With iodine In tetrahydrofuran; water at 0℃; for 2.58333h; Stage #3: With hydrogenchloride In tetrahydrofuran; water	100%

: 89-57-6
5-Aminosalicylic Acid

: 117041-94-8
3-carboxy-4-hydroxybenzenediazonium chloride

Conditions

Conditions	Yield
With hydrogenchloride; Nitrogen dioxide In water at 20℃; Reagent/catalyst;	100%

: 89-57-6
5-Aminosalicylic Acid

: 5-azido-2-hydroxybenzoic acid

Conditions

Conditions	Yield
Stage #1: 5-Aminosalicylic Acid With sulfuric acid; sodium nitrite In water at 0℃; Inert atmosphere; Stage #2: With sodium azide In water at 0 - 20℃; Inert atmosphere;	99%
Stage #1: 5-Aminosalicylic Acid With sulfuric acid; sodium nitrite In water at 0℃; for 1.5h; Inert atmosphere; Stage #2: With sodium azide In water at 0 - 20℃; for 14.5h; Inert atmosphere;	99%
Stage #1: 5-Aminosalicylic Acid With sulfuric acid; sodium nitrite In water at 0℃; for 1.5h; Stage #2: With sodium azide In water at 0 - 20℃; for 14.5h;	99%

: 89-57-6
5-Aminosalicylic Acid

: 5794-62-7
1,4-benzoquinone-2-carboxylic acid

Conditions

Conditions	Yield
With tetra(n-butyl)ammonium dichromate(VI) In dichloromethane for 0.133333h; Reflux;	99%

: 67-56-1
methanol

: 89-57-6
5-Aminosalicylic Acid

: 42753-75-3
methyl 5-amino-2-hydroxybenzoate

Conditions

Conditions	Yield
With sulfuric acid at 85℃; for 19h;	98%
With sulfuric acid for 26h; Heating;	96%
With sulfuric acid Reflux;	96%

: 915282-88-1
sulfurous acid 2-mercapto-ethyl ester

: 89-57-6
5-Aminosalicylic Acid

: 916248-51-6
5-amino-2-hydroxy-benzoic acid mercaptoethanesulfonate

Conditions

Conditions	Yield
In ethyl acetate at 20 - 25℃; for 0.5 - 0.75h;	98%

: 89-57-6
5-Aminosalicylic Acid

: 2778-42-9
1,3-bis(1-isocyanato-1-methylethyl)benzene

: 121-44-8
triethylamine

: C28H30N4O8*2C6H15N

Conditions

Conditions	Yield
In ethanol; chloroform for 4h; Reflux;	97%

...Expand

: 89-57-6
5-Aminosalicylic Acid

: barium(II) hydroxide

: barium mesalamine

Conditions

Conditions	Yield
In water for 16h;	96.5%

: 89-57-6
5-Aminosalicylic Acid

: mesalamine-d3

Conditions

Conditions	Yield
With 10% Pt/activated carbon; palladium 10% on activated carbon; hydrogen; water-d2 at 145℃; for 24h; Reagent/catalyst; Temperature; Sealed tube; regioselective reaction;	96%

: 67-56-1
methanol

: 89-57-6
5-Aminosalicylic Acid

: methyl 5-aminosalicylate hydrochloride

Conditions

Conditions	Yield
Stage #1: methanol With thionyl chloride Cooling; Stage #2: 5-Aminosalicylic Acid for 1.5h; Reflux;	96%

: 89-57-6
5-Aminosalicylic Acid

: N-tert-butoxycarbonyl-O-diethylcarbamoyl-N-bromopropylhydroxylamine

: 3-((tert-butoxycarbonyl)((diethylcarbamoyl)oxy)amino)propyl 5-amino-2-hydroxybenzoate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 60℃;	96%

: 303-45-7
(rac)-gossypol

: 89-57-6
5-Aminosalicylic Acid

: gossypolydenebis-N-(3-carboxy-4-hydroxyaniline)

Conditions

Conditions	Yield
In ethanol for 3h; Heating;	95.31%

: 89-57-6
5-Aminosalicylic Acid

: 68596-89-4
5-Diazo-salicylsaeure

Conditions

Conditions	Yield
With pyridine hydrogenfluoride; sodium nitrite 1.) O deg C, 20 min, 2.) 20 deg C, 1 h;	95%
With pyridine hydrogenfluoride; sodium nitrite 1) -50 deg C, 30 min, 2) 20 deg C, 60 min;	90%

: 89-57-6
5-Aminosalicylic Acid

: 108-24-7
acetic anhydride

: 51-59-2
N-Acetyl-5-aminosalicylic acid

Conditions

Conditions	Yield
With acetic acid In water for 0.5h; Reflux;	94%
In water; acetone at 20℃; for 1.33333h; Reflux;	94%
With multi-walled carbonnanotubes functionalized with phosphonic acid In neat (no solvent) at 20℃; for 0.333333h;	90%

: 89-57-6
5-Aminosalicylic Acid

: 1,6,9-trioxa-3,12-dithiacyclotridecane

: 2-hydroxy-5-(1,11-dioxa-4,8-dithia-6-azacyclotridecan-6-yl)benzoic acid

Conditions

Conditions	Yield
With samarium(III) nitrate hexahydrate In chloroform at 20℃; for 3h; Inert atmosphere;	94%

: 7446-70-0, 7784-13-6
aluminum (III) chloride

: 89-57-6
5-Aminosalicylic Acid

: aluminum mesalamine

Conditions

Conditions	Yield
Stage #1: 5-Aminosalicylic Acid With sodium hydroxide In water Stage #2: aluminum (III) chloride In tetrahydrofuran; water for 16h;	94%

: 108-31-6
maleic anhydride

: 89-57-6
5-Aminosalicylic Acid

: 175730-33-3
3-carboxy-4-hydroxymaleanilic acid

Conditions

Conditions	Yield
In chloroform for 0.5h;	93%
With acetic acid Ambient temperature;	46%

: 98-01-1
furfural

: 89-57-6
5-Aminosalicylic Acid

: 5-{[1-Furan-2-yl-meth-(E)-ylidene]-amino}-2-hydroxy-benzoic acid

Conditions

Conditions	Yield
In ethanol	93%

: 89-57-6
5-Aminosalicylic Acid

: C12H7F3N4O2S

: 2-hydroxy-5-(3-(6-(trifluoromethoxy)benzo[d]thiazol-2-yl)ureido)benzoic acid

Conditions

Conditions	Yield
In acetonitrile for 20h; Reflux;	93%

: 1178-81-0
tris(2-phenyl-2-methylpropyl)tin hydroxide

: 89-57-6
5-Aminosalicylic Acid

: 148-53-8
3-methoxy-2-hydroxybenzaldehyde

: tris(2‐methyl‐2‐phenylpropyl)tin 5‐(3‐methoxysalicylideneamino)salicylate

Conditions

Conditions	Yield
In ethanol; benzene for 6h; Reflux; Dean-Stark;	93%

...Expand

: 89-57-6
5-Aminosalicylic Acid

: 1202816-93-0
4-nitrososulfopyridine

: 599-79-1
sulfosalazine

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water at 20 - 50℃; pH=3; Concentration; pH-value; Temperature;	92.5%
With hydrogenchloride In methanol; water at 30 - 50℃; Temperature;	92.5%

: 89-57-6
5-Aminosalicylic Acid

: 501-53-1
benzyl chloroformate

: 143200-61-7
5-benzyloxycarbonylamino-2-hydroxy-benzoic acid

Conditions

Conditions	Yield
With sodium hydrogencarbonate at 0℃; for 5h;	92%

: 89-57-6
5-Aminosalicylic Acid

: 121-33-5
vanillin

: 2-Hydroxy-5-{[1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-amino}-benzoic acid

Conditions

Conditions	Yield
In ethanol	92%

: 89-57-6
5-Aminosalicylic Acid

: 76437-40-6
2,3,5,6-tetrafluoro-4-trifluoromethyl benzyl bromide

: 640290-67-1
2-hydroxy-TTBA

Conditions

Conditions	Yield
With triethylamine In ethanol at 25℃; for 1.5h; Reagent/catalyst; Temperature; Solvent;	91%
With triethylamine at 20℃; for 2h;	64%

: 24677-78-9
2,3-dihydroxybenzaldehyde

: 89-57-6
5-Aminosalicylic Acid

: (E)-5-((2,3-dihydroxybenzylidene)amino)-2-hydroxybenzoicacid

Conditions

Conditions	Yield
In methanol for 1h; Reflux;	91%

: 137-26-8
Thiram

: 89-57-6
5-Aminosalicylic Acid

: 264257-12-7
5-(N',N'-dimethylthioureido)salicylic acid

Conditions

Conditions	Yield
In propan-1-ol at 100℃; for 1h; Substitution; thiocarbamoylation;	90.3%

: 89-57-6
5-Aminosalicylic Acid

: 345-16-4
5-fluoro-2-hydroxybenzoic acid

Conditions

Conditions	Yield
With pyridine hydrogenfluoride; sodium nitrite 1.) O deg C, 20 min, 2.) 140 deg C, 1 h;	90%
With pyridine hydrogenfluoride; sodium nitrite 1) -50 deg C, 30 min, 2) 140 deg C, 60 min;	85%

5-Aminosalicylic acid Consensus Reports

Reported in EPA TSCA Inventory.

5-Aminosalicylic acid Specification

1. Introduction of 5-Aminosalicylic acid
5-aminosalicylic acid (5-ASA), is an anti-inflammatory drug used to treat inflammatory bowel disease, such as ulcerative colitis and mild-to-moderate Crohn's disease. The IUPAC Name is 5-Amino-2-hydroxybenzoic acid. And the classification code is Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-inflammatory; Antirheumatic Agents; Drug/Therapeutic Agent; Human Data; Peripheral Nervous System Agents; Sensory System Agents.

2. Properties of 5-Aminosalicylic acid
Melting Point: 275-280 °C
Polar Surface Area: 38.77 ?2
Index of Refraction: 1.691
Molar Refractivity: 39.3 cm3
Molar Volume: 102.6 cm3
Surface Tension: 83.3 dyne/cm
Density: 1.491 g/cm3
Flash Point: 198.1 °C
Enthalpy of Vaporization: 69.09 kJ/mol
Boiling Point: 403.9 °C at 760 mmHg
Vapour Pressure: 3.01E-07 mmHg at 25°C

3. Toxicity of 5-Aminosalicylic acid

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	51mg/kg/5D-I (51mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Lancet. Vol. 1, Pg. 917, 1984.
man	TDLo	oral	321mg/kg/15D- (321mg/kg)	SKIN AND APPENDAGES (SKIN): PHOTOSENSITIVITY: AFTER SYSTEMIC EXPOSURE	American Journal of Gastroenterology. Vol. 94, Pg. 3386, 1999.
man	TDLo	oral	2057mg/kg/17W (2057mg/kg)	BLOOD: AGRANULOCYTOSIS	Lancet. Vol. 341, Pg. 1476, 1993.
man	TDLo	oral	6857mg/kg/17W (6857mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING LIVER: "JAUNDICE, CHOLESTATIC"	Journal of Hepathology. Vol. 26, Pg. 425, 1997.
monkey	LDLo	oral	3gm/kg (3000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) KIDNEY, URETER, AND BLADDER: HEMATURIA	Oyo Yakuri. Pharmacometrics. Vol. 47, Pg. 509, 1994.
mouse	LD50	intraperitoneal	469mg/kg (469mg/kg)		Archiv der Pharmazie Vol. 332, Pg. 321, 1999.
mouse	LD50	oral	3370mg/kg (3370mg/kg)		Archiv der Pharmazie Vol. 332, Pg. 321, 1999.
rabbit	LD50	skin	> 5gm/kg (5000mg/kg)		National Technical Information Service. Vol. OTS0570511,
rat	LD50	intraperitoneal	1gm/kg (1000mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD SKIN AND APPENDAGES (SKIN): HAIR: OTHER KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION	Oyo Yakuri. Pharmacometrics. Vol. 47, Pg. 505, 1994.
rat	LD50	oral	2800mg/kg (2800mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: FOOD INTAKE (ANIMAL) GASTROINTESTINAL: OTHER CHANGES	National Technical Information Service. Vol. OTS0570511,
women	TDLo	oral	8mg/kg (8mg/kg)	BEHAVIORAL: HEADACHE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Lancet. Vol. 1, Pg. 917, 1984.
women	TDLo	oral	80mg/kg/1D-I (80mg/kg)	CARDIAC: PULSE RATE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	American Journal of Gastroenterology. Vol. 93, Pg. 470, 1998.
women	TDLo	oral	5400mg/kg/90D (5400mg/kg)	GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF ENDOCRINE PANCREAS	American Journal of Gastroenterology. Vol. 92, Pg. 2302, 1997.
women	TDLo	oral	8760mg/kg/1Y- (8760mg/kg)	BEHAVIORAL: ANOREXIA (HUMAN BEHAVIORAL: MUSCLE WEAKNESS KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	Clinical Nephrology. Vol. 49, Pg. 265, 1998.
women	TDLo	oral	21800mg/kg/39 (21800mg/kg)	LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)" LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BLOOD: EOSINOPHILIA	American Journal of Gastroenterology. Vol. 91, Pg. 1039, 1996.

4. Safety Information of 5-Aminosalicylic acid
Poison by intraperitoneal route. Moderately toxic by ingestion. Human systemic effects by ingestion: hypermotility, diarrhea, dermatitis, increased body temperature. When heated to decomposition it emits toxic fumes of NO_x.
Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-24/25
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
S24/25: Avoid contact with skin and eyes.
WGK Germany: 2
RTECS: VO1400000
F: 8-10-23
Hazard Note: Irritant
HS Code: 29225000

5. Use of 5-Aminosalicylic acid
5-Aminosalicylic acid can be used in the active metabolite of Sulfasalazine. It is administered orally or as a suppository. When administered orally, it is usually in a time-released or extended released form so it will work for an extended period of time.

6. Side Effects of 5-Aminosalicylic Acid
When taken as a suppository, possible side effects are usually limited to GI system, including but not limited to: Diarrhea; Cramping; Increased Flatulence.

7. Other details of 5-Aminosalicylic acid
Chemical Stability: Air sensitive. Light sensitive.
Conditions to Avoid: Incompatible materials, light, dust generation, exposure to air, temperatures above 30°C.
Incompatibilities with Other Materials Strong oxidizing agents, acids, acid chlorides, iron, acid anhydrides, chloroformates.
Hazardous Decomposition Products Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization Will not occur.
First Aid Measures:
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Get medical aid. Wash mouth out with water.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician: Treat symptomatically and supportively.
Handling and Storage:
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Storage: Store in a cool, dry place. Do not store in direct sunlight. Store in a tightly closed container. Store at around 20°C. Store under an inert atmosphere.

Product Name

5-Aminosalicylic acid

Synthetic route

5-Aminosalicylic acid Consensus Reports

5-Aminosalicylic acid Specification

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