6-Methoxy-2-Naphthaldehyde supplier

Name
6-Methoxy-2-naphthaldehyde
EINECS 222-377-2
CAS No. 3453-33-6
Article Data67
CAS DataBase
Density 1.169 g/cm³
Solubility 150.1mg/L at 25℃
Melting Point 80-82 °C
Formula C₁₂H₁₀O₂
Boiling Point 340.2 °C at 760 mmHg
Molecular Weight 186.21
Flash Point 162.7 °C
Transport Information
Appearance Slightly yellow crystalline powder
Safety 26-36-24/25-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 2-Naphthaldehyde,6-methoxy- (6CI,7CI,8CI);2-Methoxy-6-naphthalenecarboxaldehyde;6-Methoxy-2-naphthalenecarboxaldehyde;MONAL 62;6-Methoxy-2-naphthaldehyde;
PSA 26.30000
LogP 2.66090

Synthetic route

: 5111-65-9
2-Bromo-6-methoxynaphthalene

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃;	97%
Stage #1: 2-Bromo-6-methoxynaphthalene With n-butyllithium In tetrahydrofuran Stage #2: N,N-dimethyl-formamide	90%
Stage #1: 2-Bromo-6-methoxynaphthalene With n-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 0.25h; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; cyclohexane at -78℃; for 0.25h; Further stages.;	74%

: 60201-22-1
(6-methoxy-2-naphthyl)methanol

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In water; acetic acid for 4h; Heating;	95%
With 1-hydroxy-1H-1,2,3-benziodoxathiole 1,3,3-trioxide; Oxone; cetyltrimethylammonim bromide In water at 20℃; for 2h; Green chemistry; chemoselective reaction;	95%
With pyridinium chlorochromate In dichloromethane at 20℃;

: 92190-49-3
(6-methoxynaphthalene-2-yl)methyl acetate

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In water; acetic acid for 4h; Heating;	95%

: C13H13N3O2

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

Conditions

Conditions	Yield
With (Bu4N)2S2O8 In 1,2-dichloro-ethane at 80℃; for 0.6h; oxidative cleavage;	94%

: 201230-82-2
carbon monoxide

: 5111-65-9
2-Bromo-6-methoxynaphthalene

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; hydrogen; palladium diacetate; propyl di-tert-butylphosphinite In toluene at 100℃; under 3750.38 Torr; for 20h; Inert atmosphere;	93%
With N,N,N,N,-tetramethylethylenediamine; hydrogen; palladium diacetate; catacxium A In toluene at 120℃; under 9000.9 Torr; Flow reactor; Green chemistry;	84%
With 4-methoxy-N'-tetramethylethylenediamine; hydrogen; catacxium A; palladium diacetate In toluene at 100℃; under 3750.3 Torr; for 16h;	99 % Chromat.
With N,N,N,N,-tetramethylethylenediamine; hydrogen; catacxium A; palladium diacetate In toluene at 100℃; under 3750.38 Torr; for 16h;	99 % Chromat.

: 26386-94-7
2-methyl-6-methoxynaphthalene

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In water; acetic acid for 5h; Heating;	90%
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In water; acetic acid for 4h; Heating;	90%

: 201230-82-2
carbon monoxide

: C11H9FO4S

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

Conditions

Conditions	Yield
With pyridine; 1,3-bis-(diphenylphosphino)propane; hydrogen; palladium diacetate In dimethyl sulfoxide at 120℃; under 7500.75 Torr; for 2h; Flow reactor;	90%

: 5111-65-9
2-Bromo-6-methoxynaphthalene

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; N,N-dimethyl-formamide at -78 - 20℃; for 2h; Inert atmosphere;	88.6%
With n-butyllithium In tetrahydrofuran; hexane; N,N-dimethyl-formamide
With magnesium; acetic acid In tetrahydrofuran; N,N-dimethyl-formamide

: oxime of 6-methoxy-2-naphthyl aldehyde

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

Conditions

Conditions	Yield
With (Bu4N)2S2O8 In 1,2-dichloro-ethane for 1.5h; Heating;	87.5%

: 50-00-0
formaldehyd

: 5111-65-9
2-Bromo-6-methoxynaphthalene

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

Conditions

Conditions	Yield
With triethylsilane; dichloro bis(acetonitrile) palladium(II); sodium carbonate; 1,4-di(diphenylphosphino)-butane In N,N-dimethyl-formamide at 20 - 100℃; under 15001.5 Torr; for 20h; Inert atmosphere; Autoclave;	61%

: 581-42-0
2.6-dimethylnaphthalene

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In water; acetic acid for 4h; Heating;	50%

: 3-hydroxy-4-(6-methoxynaphthalen-2-yl)butan-2-one

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

Conditions

Conditions	Yield
With copper(II) acetate monohydrate In ethanol; water at 60℃; for 5h;	40%

: 67886-70-8
2-cyano-6-methoxynaphthalene

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

Conditions

Conditions	Yield
With diisobutylaluminium hydride In n-heptane; toluene at -40℃; for 1h;	22%

: 23981-48-8
methyl 6-methoxy-2-naphthylacetate

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

Conditions

Conditions	Yield
With oxygen In acetonitrile for 0.25h; Oxidation; decarboxylation; Irradiation;	2%

: 58601-32-4
6-methoxy-2-naphthoyl chloride

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

Conditions

Conditions	Yield
With quinoline; Pd-BaSO4; sulfur Hydrogenation.Reagens 4:Xylol;

: 58902-04-8
(E)-2-methoxy-6-(prop-1-en-1-yl)naphthalene

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

Conditions

Conditions	Yield
With osmium(VIII) oxide; periodic acid

: 408528-32-5
N-benzenesulfonyl-N'-(6-methoxy-[2]naphthoyl)-hydrazine

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

Conditions

Conditions	Yield
With sodium carbonate; ethylene glycol

: 38046-82-1
6-methoxynaphthalen-2-ylmagnesium bromide

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

Conditions

Conditions	Yield
With tetrahydrofuran; N,N-dimethyl-formamide

: 38046-82-1
6-methoxynaphthalen-2-ylmagnesium bromide

: 122-51-0
orthoformic acid triethyl ester

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

Conditions

Conditions	Yield
With diethyl ether; benzene Erhitzen des nach dem Eindampfen erhaltenen Rueckstands auf 100grad und anschlissendes Behandeln mit Eis und Essigsaeure;

: 23981-47-7
6-methoxy-2-naphthylacetic acid

A: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

B: 60201-22-1
(6-methoxy-2-naphthyl)methanol

Conditions

Conditions	Yield
With oxygen In phosphate buffer for 0.25h; Product distribution; Further Variations:; Solvents; addition of CCl4; without O2; Oxidation; decarboxylation; Irradiation;

: 220786-56-1, 98386-83-5
(±)-4-hydroxy-4-(6-methoxy-2-naphthyl)-2-butanone

A: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

B: 67-64-1
acetone

C: (S)-4-hydroxy-4-(6-methoxynaphthalen-2-yl)butan-2-one

Conditions

Conditions	Yield
With phosphate buffer; sodium chloride; antibody 93F3 from mice pH=7.4; Enzyme kinetics; Further Variations:; Catalysts; Kinetic resolution; Retro aldol reaction;

...Expand

: 1-hydroxy-1-(6-methoxynaphthalen-2-yl)pentan-3-one

A: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

B: 78-93-3
butanone

C: (S)-1-Hydroxy-1-(6-methoxy-naphthalen-2-yl)-pentan-3-one

Conditions

Conditions	Yield
With phosophate buffer; antibody 93F3 from mice pH=7.7; Enzyme kinetics; Further Variations:; Catalysts; Kinetic resolution; Retro aldol reaction;

...Expand

: 220786-56-1, 98386-83-5
(±)-4-hydroxy-4-(6-methoxy-2-naphthyl)-2-butanone

A: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

B: 67-64-1
acetone

Conditions

Conditions	Yield
With aldolase antibody Fab 28 In dimethyl sulfoxide at 25℃; pH=7.4; Kinetics; Further Variations:; Reagents; retro-aldolization; Enzymatic reaction;
With YLK-18-opt peptide In phosphate buffer; acetonitrile at 25℃; pH=7.5; Enzyme kinetics; Further Variations:; Reagents;
With recombinant mutant Tyr78Phe RA61 retroaldolase; water In dimethyl sulfoxide at 25℃; pH=7.5; Kinetics; Reagent/catalyst; aq. phosphate buffer; Enzymatic reaction;
With C39H60N6O5 In aq. phosphate buffer pH=7.45; Catalytic behavior; Kinetics; Reagent/catalyst; Solvent;

: 2-(hydroxy(6-methoxynaphthalen-2-yl)methyl)cyclohexanone

A: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

B: 108-94-1
cyclohexanone

Conditions

Conditions	Yield
With aldolase antibody Fab 28 In dimethyl sulfoxide at 25℃; pH=7.4; Kinetics; Further Variations:; Reagents; retro-aldolization; Enzymatic reaction;

: 2-(hydroxy(6-methoxynaphthalen-2-yl)methyl)cyclohexanone

A: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

B: 108-94-1
cyclohexanone

Conditions

Conditions	Yield
With aldolase antibody Fab 28 In dimethyl sulfoxide at 25℃; pH=7.4; Kinetics; Further Variations:; Reagents; retro-aldolization; Enzymatic reaction;

: (R)-2-[(S)-Hydroxy-(6-methoxy-naphthalen-2-yl)-methyl]-cyclohexanone

A: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

B: 108-94-1
cyclohexanone

Conditions

Conditions	Yield
With YLK-18-opt peptide In phosphate buffer; dimethyl sulfoxide at 25℃; pH=7.5; Enzyme kinetics; Further Variations:; Reagents;

: 377088-74-9
(R)-2-(6-methoxy-2-naphthyl)-1,2-epoxyethane

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

Conditions

Conditions	Yield
With sodium periodate; bovine serum albumin In phosphate buffer; N,N-dimethyl-formamide at 26℃; pH=7.2; Enzyme kinetics; Further Variations:; pH-values;

: 473999-53-0
(+/-)-2-(6-methoxy-2-naphthyl)-1,2-ethanediol

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

Conditions

Conditions	Yield
With sodium periodate; bovine serum albumin In phosphate buffer; N,N-dimethyl-formamide at 26℃; pH=7.2; Enzyme kinetics; Further Variations:; pH-values;

: 220786-56-1, 98386-83-5
(±)-4-hydroxy-4-(6-methoxy-2-naphthyl)-2-butanone

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

Conditions

Conditions	Yield
With sodium phosphate In acetonitrile at 25℃; pH=7.5; Enzyme kinetics;
With mAb 38C2
With monoclonal aldolase antibody 85H6 In ethanol retro-aldol reaction; aq. phosphate buffer;

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: 7417-21-2
2-(3,4-dimethoxyphenyl)ethyl alcohol

: 1220970-36-4
3,4-dihydro-6,7-dimethoxy-1-(2-methoxynaphthalen-6-yl)-1H-isochromene

Conditions

Conditions	Yield
With bismuth(lll) trifluoromethanesulfonate; water In toluene at 80℃; oxa Pictet-Spengler reaction;	99%

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: oxime of 6-methoxy-2-naphthyl aldehyde

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; sodium hydroxide In ethanol at 80℃; for 4h; Inert atmosphere;	99%
With hydroxylamine hydrochloride; sodium acetate In ethanol at 20℃; for 6h;

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: 67886-70-8
2-cyano-6-methoxynaphthalene

Conditions

Conditions	Yield
With ammonium sulfate; sodium carbonate; sulfur In dimethyl sulfoxide at 120℃; for 10h; Sealed tube;	99%
With oxygen; copper(ll) bromide; potassium hexacyanoferrate(III) In N,N-dimethyl-formamide at 150℃; for 12h; Sealed tube;	73%
Multi-step reaction with 2 steps 1: sodium acetate / methanol; water / 20 °C 2: bis[2-(diphenylphosphino)phenyl] ether; bis(1,5-cyclooctadiene)nickel (0) / tetrahydrofuran / 17 h / 60 °C View Scheme

: 16532-79-9
4-Bromophenylacetonitrile

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: C20H14BrNO

Conditions

Conditions	Yield
In ethanol at 20℃; Alkaline conditions;	99%
With alkali hydroxide In ethanol at 20℃;	99%

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: 60201-22-1
(6-methoxy-2-naphthyl)methanol

Conditions

Conditions	Yield
With sodium tetrahydroborate In ethanol at 0 - 20℃; for 0.333333h; Inert atmosphere;	98%
With lithium aluminium tetrahydride	95%
With sodium tetrahydroborate In methanol; water for 2h; Ambient temperature;	91.7%

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: 2,5-dimethylbenzyl triphenylphosphonium chloride

: 1-(2,5-dimethylphenyl)-2-(6-methoxy-2-naphthyl)ethene

Conditions

Conditions	Yield
Stage #1: 2,5-dimethylbenzyl triphenylphosphonium chloride With sodium methylate In methanol at 20℃; for 1.5h; Stage #2: 6-methoxynaphthalene-2-carbaldehyde In methanol for 36h; Further stages.;	98%

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: 141-97-9
ethyl acetoacetate

: 57-13-6
urea

: ethyl 4-(6-methoxynaphthalen-2-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Conditions

Conditions	Yield
Wells-Dawson heteropolyacid catalyst at 80℃; for 1.5h; Biginelli reaction;	98%
With polyvinylsulfonic acid In water at 90℃; for 1.66667h; Solvent; Temperature; Biginelli Pyrimidone Synthesis; Green chemistry;	86%

...Expand

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: 100-46-9
benzylamine

: benzyl-(6-methoxy-naphthalen-2-ylmethylene)-amine

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane	98%

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: 615-43-0
2-iodophenylamine

: 1345838-83-6
C18H14N2O

Conditions

Conditions	Yield
With sodium azide; N,N,N,N,-tetramethylethylenediamine; copper(l) chloride In dimethyl sulfoxide at 120℃; for 12h;	98%

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: 24350-54-7
diisopropyl trimethylsily phosphite

: (R)-diisopropyl (hydroxy(6-methoxynaphthalen-2-yl)methyl)phosphonate

Conditions

Conditions	Yield
With 3,3’-bis[3,5-bis(perfluoropropan-2-yl)phenyl]-1,1’-binaphthalene-2,2’-sulfonimide In diethyl ether at -78℃; for 96h; Abramov Phosphorylation; enantioselective reaction;	98%

: 870-50-8
di-tert-butyl-diazodicarboxylate

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: 103421-61-0
3-amino-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

: di-tert-butyl 5'-(6-methoxynaphthalen-2-yl)-1-methyl-2-oxo-5-phenyl-1,2-dihydrospiro[benzo[e][1,4]diazepine-3,3'-[1,2,4]triazolidine]-1',2'-dicarboxylate

Conditions

Conditions	Yield
With benzoic acid In tetrahydrofuran at 20℃; for 24h; diastereoselective reaction;	98%
With benzoic acid In tetrahydrofuran at 20℃; for 24h;	98%

...Expand

: 75-52-5
nitromethane

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: 30780-82-6
2-methoxy-6-(2-nitrovinyl)naphthalene

Conditions

Conditions	Yield
With ammonium acetate; acetic acid at 90 - 100℃; Aldol Condensation;	97.4%
With methylamine hydrochloride; sodium acetate In methanol at 20℃; for 2h;

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: 67-64-1
acetone

: 127053-22-9, 56600-90-9
4-(2-methoxynaphthalene-6-yl)but-3-en-2-one

Conditions

Conditions	Yield
With sodium hydroxide In water at 70℃; for 0.125h; Aldol condensation; Microwave irradiation; Continuous flow;	97%
With sodium hydroxide
With sodium hydroxide In water for 4h; Aldol Condensation;
With Nickel-Lanthanum-Magnesium mixed oxide on mesoporous silica at 140℃; for 6h; Reagent/catalyst;

: 373-44-4
1,8-diaminooctan

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: 1075173-24-8
N,N'-bis[(6-methoxynaphthalen-2-yl)methylene]octane-1,8-diamine

Conditions

Conditions	Yield
In ethanol for 0.5h; Heating;	97%

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: 1439-36-7
1-triphenylphosphoranylidene-2-propanone

: 127053-22-9, 56600-90-9
4-(2-methoxynaphthalene-6-yl)but-3-en-2-one

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 210℃; Wittig reaction; Continuous flow;	97%

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: 17763-67-6
Phenyl triflate

: 84255-35-6
(6-methoxynaphthalen-2-yl)(phenyl)methanone

Conditions

Conditions	Yield
With 2,2,6,6-tetramethyl-piperidine; bis(1,5-cyclooctadiene)nickel (0); [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In toluene at 110℃; for 20h; Inert atmosphere; Sealed tube;	97%

: 27318-90-7
1,10-phenanthroline-5,6-dione

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: 2-(6-methoxynaphthyl)-1H-imidazo[4,5-f][1,10]phenanthroline

Conditions

Conditions	Yield
With ammonium acetate; acetic acid at 180℃; for 0.25h; Microwave irradiation;	97%

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: (6-methoxy-naphthalen-2-ylmethylene)-methyl-amine

Conditions

Conditions	Yield
With magnesium sulfate; methylamine In ethanol; dichloromethane	96%

: 124-09-4
1,6-Hexanediamine

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: 1075173-23-7
N,N'-bis[(6-methoxynaphthalen-2-yl)methylene]hexane-1,6-diamine

Conditions

Conditions	Yield
In ethanol for 0.5h; Heating;	96%

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: 5782-85-4
3,4,5-trihydroxybenzoic acid hydrazide

: (E)-3,4,5-trihydroxy-N’-((6-methoxynaphthalen-2-yl)methylene)benzohydrazide

Conditions

Conditions	Yield
In methanol for 16h; Reflux;	96%

: 917481-50-6
1-(isopropylsulfonyl)-3,5-bis(trifluoromethyl)benzene

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: 211871-45-3
2-methoxy-6-(2-methylprop-1-en-1-yl)naphthalene

Conditions

Conditions	Yield
With phosphazene base-P4-tert-butyl In tetrahydrofuran; hexane at 20℃; Julia-Kocienski olefination;	95%

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: 93-04-9
2-Methoxynaphthalene

Conditions

Conditions	Yield
With rhodium(II) acetate; 1,3-bis-(diphenylphosphino)propane In toluene at 200℃; under 7500.75 Torr; Inert atmosphere;	95%

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: C12H12N2O

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol at 20℃; for 12h;	95%

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: 21204-67-1
methyl (triphenylphosphoranylidene)acetate

: 3-(6-methoxynaphthalen-2-yl)propan-1-ol

Conditions

Conditions	Yield
Stage #1: 6-methoxynaphthalene-2-carbaldehyde; methyl (triphenylphosphoranylidene)acetate In dichloromethane at 20℃; for 24h; Inert atmosphere; Stage #2: With methanol; sodium hydride In tetrahydrofuran at 55℃; for 6.5h; Inert atmosphere;	95%

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: 108-59-8
malonic acid dimethyl ester

: dimethyl 2-[(6-methoxynaphthalen-2-yl)methylene]malonate

Conditions

Conditions	Yield
With piperidine; acetic acid In benzene Dean-Stark; Reflux;	95%

: 61-54-1
tryptamine

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: 2-(1H-indol-3-yl)-N-((6-methoxynaphthalen-2-yl)methyl)ethan-1-amine

Conditions

Conditions	Yield
Stage #1: tryptamine; 6-methoxynaphthalene-2-carbaldehyde In methanol at 20℃; for 4h; Inert atmosphere; Stage #2: With methanol; sodium tetrahydroborate at 0℃; for 1h; Inert atmosphere;	95%

6-Methoxy-2-Naphthaldehyde Specification

The 6-Methoxy-2-Naphthaldehyde is an organic compound with the formula C₁₂H₁₀O₂. The IUPAC name of this chemical is 6-methoxynaphthalene-2-carbaldehyde. With the CAS registry number 3453-33-6 and EINECS 222-377-2, it is also named as 2-naphthalenecarboxaldehyde, 6-methoxy-. The product's categories are Aromatic Aldehydes & Derivatives (substituted); Aldehydes; C10 to C21; Carbonyl Compounds. It is slightly yellow crystalline powder which is stable under normal temperature and pressure. Additionally, this chemical should be sealed in the container and stored in the cool and dry place.

Physical properties about 6-Methoxy-2-Naphthaldehyde are: (1)ACD/LogP: 2.63; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.63; (4)ACD/LogD (pH 7.4): 2.63; (5)ACD/BCF (pH 5.5): 58.72 ; (6)ACD/BCF (pH 7.4): 58.72; (7)ACD/KOC (pH 5.5): 642.26; (8)ACD/KOC (pH 7.4): 642.26; (9)#H bond acceptors: 2; (10)#Freely Rotating Bonds: 2; (11)Index of Refraction: 1.642 ; (12)Molar Refractivity: 57.527 cm³; (13)Molar Volume: 159.218 cm³; (14)Polarizability: 22.805 10-24cm³; (15)Surface Tension: 45.2000007629395 dyne/cm; (16)Density: 1.17 g/cm³; (17)Flash Point: 162.74 °C; (18)Enthalpy of Vaporization: 58.375 kJ/mol; (19)Boiling Point: 340.216 °C at 760 mmHg

Preparation of 6-Methoxy-2-Naphthaldehyde: It can be obtained by methyl-(6-methyl-[2]naphthyl)-ether. This reaction needs reagent 2,3-dichloro-5,6-dicyano-1,4-benzoquinone and solvents acetic acid, H₂O by heating. The reaction time is 4.0 hours. The yield is 90%.

Preparation of 6-Methoxy-2-Naphthaldehyde

Uses of 6-Methoxy-2-Naphthaldehyde: It is used as intermediate of Nabumetone. It is also used for fluorometric assays for isozymes of human alcohol dehydrogenase. What's more, it can react with malonic acid diethyl ester to get (6-methoxy-[2]naphthylmethylene)-malonic acid diethyl ester. This reaction needs reagent piperidine, benzoic acid and solvent benzene by heating. The reaction time is 16 hours. The yield is 81%.

When you are using this chemical, please be cautious about it as the following:
It is irritating to eyes, respiratory system and skin, so people should avoid contact with skin and eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection.

People can use the following data to convert to the molecule structure.
1. SMILES:O=Cc1ccc2c(c1)ccc(OC)c2
2. InChI:InChI=1/C12H10O2/c1-14-12-5-4-10-6-9(8-13)2-3-11(10)7-12/h2-8H,1H3
3. InChIKey:VZBLASFLFFMMCM-UHFFFAOYAL

Product Name

6-Methoxy-2-naphthaldehyde

Synthetic route

6-Methoxy-2-Naphthaldehyde Specification

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