Product Name

  • Name

    Acetanilide

  • EINECS 203-150-7
  • CAS No. 103-84-4
  • Article Data1332
  • CAS DataBase
  • Density 1.103 g/cm3
  • Solubility slightly soluble in water
  • Melting Point 113-115 °C(lit.)
  • Formula C8H9NO
  • Boiling Point 304.5 °C at 760 mmHg
  • Molecular Weight 135.166
  • Flash Point 173.9 °C
  • Transport Information
  • Appearance odourless solid chemical of leaf or flake-like appearance
  • Safety 22-26-36
  • Risk Codes 22-36/37/38
  • Molecular Structure Molecular Structure of 103-84-4 (Acetanilide)
  • Hazard Symbols HarmfulXn
  • Synonyms Acetanilide;Acetanilide(8CI);Acetamidobenzene;Acetanil;Acetylaniline;Antifebrin;Benzenamine, N-acetyl-;N-Acetylaminobenzene;N-Acetylaniline;N-Phenylacetamide;NSC 203231;NSC 7636;Phenalgene;Phenalgin;Antifebrin;acetamide, N-phenyl-;N-Acetylaniline;N-Phenylacetamid;N-phenylacetamide;N-Phénylacétamide;
  • PSA 29.10000
  • LogP 1.71800

Synthetic route

acetophenone oxime
613-91-2

acetophenone oxime

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With mesoporous silica chloride (SBA-Cl) In toluene for 3h; Beckmann rearrangement; Reflux;100%
trimethylsilylperrhenate; 3,5-bis-trifluromethylphenylboronic acid In acetonitrile at 120℃; for 4h; Product distribution / selectivity; Beckmann Rearrangement; Heating / reflux;99%
With p-toluenesulfonyl chloride; zinc(II) chloride In acetonitrile for 1h; Beckmann rearrangement; Inert atmosphere; Reflux;99%
4-bromoacetanilide
103-88-8

4-bromoacetanilide

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With 4-methyl-morpholine; tetrahydroxydiboron; 5%-palladium/activated carbon In 1,2-dichloro-ethane at 50℃; for 4h;100%
With lithium Zersetzen des Reaktionsprodukts mit Wasser;
With calcium Zersetzen des Reaktionsprodukts mit Wasser;
With formic acid; C59H60N6O2Pt; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 12h; Inert atmosphere; Sealed tube; UV-irradiation;62 %Spectr.
acetic anhydride
108-24-7

acetic anhydride

nitrobenzene
98-95-3

nitrobenzene

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With ammonium formate; titanium(IV) oxide; β‐cyclodextrin In water for 2.5h; Irradiation; Inert atmosphere;100%
Stage #1: nitrobenzene With sodium tetrahydroborate In water at 20℃; for 0.5h; Green chemistry;
Stage #2: acetic anhydride In water at 20℃; for 1.83333h; Catalytic behavior; Green chemistry;		99%
Stage #1: nitrobenzene With sodium tetrahydroborate; water In neat (no solvent) at 20℃; for 0.0166667h;
Stage #2: acetic anhydride In neat (no solvent) at 40℃; for 0.0333333h; Reagent/catalyst; Solvent;		97%
acetic anhydride
108-24-7

acetic anhydride

aniline
62-53-3

aniline

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With pyridine; aluminum oxide at 93 - 95℃; for 1h; microwave irradiation;100%
In dichloromethane at 20℃; Inert atmosphere;100%
In dichloromethane at 21℃; Inert atmosphere;100%
acetic acid
64-19-7

acetic acid

aniline
62-53-3

aniline

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With dmap; 2-chloro-1-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-henicosafluorododecyl)pyridinium trifluoromethanesulfonate; triethylamine In N,N-dimethyl-formamide at 20℃; for 1h;100%
With dmap; 2-chloro-1-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-henicosafluorododecyl)pyridinium trifluoromethanesulfonate; triethylamine In N,N-dimethyl-formamide at 20℃; for 1h;100%
With zinc(II) oxide for 2.33h; Reflux; chemoselective reaction;99%
acetamide
60-35-5

acetamide

iodobenzene
591-50-4

iodobenzene

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With acetamide; potassium phosphate; CuI In dodecane; ethyl acetate; toluene100%
With potassium phosphate; copper(l) iodide; L-arginine In 1,4-dioxane at 100℃; for 24h; Goldberg reaction;99%
With aluminum oxide; potassium fluoride; copper(l) iodide; 1,10-Phenanthroline In toluene at 110℃; for 5h;97%
phenyl isocyanate
103-71-9

phenyl isocyanate

acetic acid
64-19-7

acetic acid

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With zinc diacetate for 2h; Heating;100%
In toluene for 24h; Yield given;
N-(phenyl)bromoacetamide
5326-87-4

N-(phenyl)bromoacetamide

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With indium; acetic acid In methanol at 20℃; for 1h;100%
With nickel In isopropyl alcohol for 20h; Heating;81%
With tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) In toluene for 14h; Heating;81%
Multi-step reaction with 2 steps
1: 64 percent / NaBH4, 5percent aq. NaOH / ethanol
2: 24 percent / lithium 2-thienyltellurolate / tetrahydrofuran / 0.5 h
View Scheme
N-(4-chlorophenyl)acetamide
539-03-7

N-(4-chlorophenyl)acetamide

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With 4-methyl-morpholine; tetrahydroxydiboron; 5%-palladium/activated carbon In 1,2-dichloro-ethane at 50℃; for 1h;100%
acetamide
60-35-5

acetamide

chlorobenzene
108-90-7

chlorobenzene

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With C33H37N4P; potassium carbonate; bis(dibenzylideneacetone)-palladium(0) In tert-butyl alcohol at 95℃; for 18h; Catalytic behavior; Solvent; Temperature; Reagent/catalyst; Time; Inert atmosphere; Sonication;99.1%
With 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; potassium carbonate In 1,4-dioxane at 90℃; for 18h; Buchwald-Hartwig Coupling; Inert atmosphere; Glovebox;80%
With potassium phosphate; copper(l) iodide In N,N-dimethyl-formamide at 120℃; for 48h; Ullmann condensation;33%
With copper(l) iodide; potassium carbonate; pipecolic Acid In N,N-dimethyl-formamide at 110℃; for 30h; Goldberg coupling reaction;24%
With C33H37N4P; potassium carbonate; bis(dibenzylideneacetone)-palladium(0) In tert-butyl alcohol at 95℃; for 18h; Catalytic behavior; Reagent/catalyst; Solvent; Inert atmosphere; Sonication;
(E)-1-phenylethanone oxime
10341-75-0

(E)-1-phenylethanone oxime

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With 1,3,5-trichloro-2,4,6-triazine; zinc(II) chloride In acetonitrile for 2h; Beckmann rearrangement; Heating;99%
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In tetrahydrofuran; ethyl acetate at 70℃; for 2h; Beckmann rearrangement; Inert atmosphere;99%
With oxalyl dichloride at 0 - 20℃; for 2h; Catalytic behavior; Reagent/catalyst; Time; Beckmann Rearrangement;99%
thioacetanilide
637-53-6

thioacetanilide

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With 6H(1+)*Mo9O40PV3(6-); oxygen In acetonitrile at 60℃; under 760.051 Torr; for 0.5h; Inert atmosphere; Glovebox;99%
With eosin; oxygen In N,N-dimethyl-formamide at 20℃; for 6h; Reagent/catalyst; Solvent; Irradiation; Green chemistry;93%
With P,P-dichlorophenylphosphine oxide In acetonitrile at -4℃; for 3h;90%
acetyl chloride
75-36-5

acetyl chloride

aniline
62-53-3

aniline

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With ruthenium(III) 2,4-pentanedionate at 25℃; for 0.0833333h;99%
In water at 80℃; for 0.0833333h; Microwave irradiation; Green chemistry; chemoselective reaction;98%
With thermally decomposed Ni-Fe-hydrotalcite at 26.84℃; for 0.0166667h; Neat (no solvent);97%
vinyl acetate
108-05-4

vinyl acetate

aniline
62-53-3

aniline

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With immobilization of Candida cylindracea lipase In hexane at 55℃; for 28h;99%
With 1-(3-sulfopropyl)pyridinium phosphotungstate In neat (no solvent) at 120℃; for 1h; Microwave irradiation;92%
With Candida antarctica lipase B; acetone oxime In tert-butyl methyl ether at 20℃; for 4h; Molecular sieve;84%
Acetic acid 3,6-diisobutyl-pyrazin-2-yl ester
87386-71-8

Acetic acid 3,6-diisobutyl-pyrazin-2-yl ester

aniline
62-53-3

aniline

A

Acetanilid
103-84-4

Acetanilid

B

2-hydroxy-3,6-diisobutylpyrazine
495-98-7

2-hydroxy-3,6-diisobutylpyrazine

Conditions
ConditionsYield
In benzene for 15h; Ambient temperature;A 99%
B n/a
In benzene for 15h; Product distribution; Ambient temperature;A 99%
B n/a
...Expand
(Z)-N′-phenylbenzimidamide
1527-91-9

(Z)-N′-phenylbenzimidamide

A

N1-(N-phenylcarbamoyl)-N2-phenylbenzimidamide
33655-23-1

N1-(N-phenylcarbamoyl)-N2-phenylbenzimidamide

B

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With [bis(acetoxy)iodo]benzene In toluene at 110℃;A 99%
B 80%
N-phenylbenzamidine
1527-91-9

N-phenylbenzamidine

A

N1-(N-Phenylcarbamoyl)-N2-phenylbenzimidamide
33655-23-1

N1-(N-Phenylcarbamoyl)-N2-phenylbenzimidamide

B

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With [bis(acetoxy)iodo]benzene In toluene at 110℃;A 99%
B 80%
aniline
62-53-3

aniline

acetonitrile
75-05-8

acetonitrile

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With aluminum oxide at 200℃; under 37503.8 Torr; for 0.45h; Reagent/catalyst; Temperature; Sonication; Green chemistry;99%
Stage #1: aniline With tetrafluoroboric acid In water
Stage #2: acetonitrile With potassium phosphate; water at 80℃; for 12h; Temperature; Reagent/catalyst; Inert atmosphere;		89%
With tert.-butylnitrite; tetrabutylammomium bromide; water; toluene-4-sulfonic acid at 60℃; for 23h;87%
Isopropenyl acetate
108-22-5

Isopropenyl acetate

aniline
62-53-3

aniline

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With iodine at 85 - 90℃; for 0.0833333h;99%
With iron(III) trifluoromethanesulfonate at 20℃; for 24h; Schlenk technique;85%
With 1,2,4-Triazole; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃; for 10h;69%
In neat (no solvent) at 20℃; for 24h; Concentration; Time; Green chemistry;69%
With cell-free extract containing recombinant PpATaseCH In aq. phosphate buffer; dimethyl sulfoxide at 35℃; for 18h; pH=7.5;
ethanol
64-17-5

ethanol

aniline
62-53-3

aniline

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With oxygen; sodium hydroxide In water at 40℃; for 18h; Green chemistry;99%
With oxygen; sodium hydroxide In water at 40℃; for 24h; Reagent/catalyst;99%
With oxygen; lithium hydroxide In water at 50℃; for 12h;86%
methanol
67-56-1

methanol

benzamide
55-21-0

benzamide

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With N-methyl-N-[3-(4-diacetoxyiodo)phenoxy-1-propyl]pyrrolidinium 4-methylbenzenesulfonate; potassium hydroxide In chloroform at 0 - 20℃; Hofmann Rearrangement; Inert atmosphere;99%
phenyl isocyanate
103-71-9

phenyl isocyanate

bis(iodozinc)methane
31729-70-1

bis(iodozinc)methane

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
Stage #1: phenyl isocyanate; bis(iodozinc)methane at 80℃; for 0.5h;
Stage #2: at 25℃; Acidic conditions;		99%
In tetrahydrofuran at 80℃; for 0.5h; Solvent;99%
4-(phenylamino)pent-3-en-2-one
7294-89-5, 26567-78-2, 147054-81-7

4-(phenylamino)pent-3-en-2-one

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With dihydrogen peroxide In water at 20℃; for 0.5h; Green chemistry;99%
With 2,2'-azobis(isobutyronitrile); oxygen In acetonitrile at 80℃; for 12h; Sealed tube;80%
With tert.-butylhydroperoxide In water; chlorobenzene at 80℃; for 2h;75%
With 5,6-bis(5-methoxythiophen-2-yl)pyrazine-2,3-dicarbonitrile; oxygen In acetonitrile at 25℃; for 12h; Solvent; Irradiation; chemoselective reaction;74%
o-iodoacetanilide
19591-17-4

o-iodoacetanilide

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With 2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline bis[(2-diphenyl-phosphino)phenyl]ether copper(I) hexafluorophosphate; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 16h; Inert atmosphere; Sealed tube; Irradiation;99%
With 2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline bis[(2-diphenyl-phosphino)phenyl]ether copper(I) hexafluorophosphate; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 16h; UV-irradiation;99%
With copper acetylacetonate; diethylamine; vasicine In ethanol at 100℃; for 12h; Time; Sealed tube;88%
With copper acetylacetonate; ethanol; diethylamine; vasicine at 100℃; for 12h; Sealed tube; regioselective reaction;86%
With potassium phosphate; palladium diacetate; hydrazine hydrate In dimethyl sulfoxide; N,N-dimethyl-formamide at 20℃; for 8h; Green chemistry;83%
acetic anhydride
108-24-7

acetic anhydride

acetic acid
64-19-7

acetic acid

aniline
62-53-3

aniline

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
at 20℃; for 0.5h; Reflux;98%
for 0.5h; Reflux;98%
...Expand
acetamide
60-35-5

acetamide

aniline
62-53-3

aniline

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With Fe3+ exchanged montmorillonite K-10 In neat (no solvent) at 110℃; for 30h; Catalytic behavior; Reagent/catalyst; Temperature; Inert atmosphere;98%
With dipotassium peroxodisulfate In water at 100℃; for 0.166667h; Solvent; Temperature; Time; Reagent/catalyst; Microwave irradiation; Green chemistry;97%
With [Ru-NHC] In toluene at 110℃; for 8h; Catalytic behavior; Solvent; Temperature; Reagent/catalyst; Inert atmosphere; Schlenk technique; Sealed tube;94%
acetophenone
98-86-2

acetophenone

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With acetylhydroxamic acid; sulfuric acid In acetonitrile for 0.5h; Reflux;98%
With mesitylenesulfonylhydroxylamine In acetonitrile at 20℃; for 5h; Reagent/catalyst; Solvent;98%
With zinc(II) chloride; hydroxylamine-O-sulfonic acid In water at 20℃; for 8h; Reagent/catalyst; Solvent; Beckmann Rearrangement;96%
1-(2-thioxobenzo[d]oxazol-3(2H)-yl)ethanone
37441-95-5

1-(2-thioxobenzo[d]oxazol-3(2H)-yl)ethanone

aniline
62-53-3

aniline

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
In tetrahydrofuran at 15℃; for 0.166667h;98%
m-4-acetamidophenyl trifluoromethanesulfonate
32578-30-6

m-4-acetamidophenyl trifluoromethanesulfonate

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
With 4-methyl-morpholine; tetrahydroxydiboron; 5%-palladium/activated carbon In 1,2-dichloro-ethane at 50℃; for 5h;98%
With ammonium acetate; magnesium; palladium on activated charcoal In methanol at 20℃; for 1h;97%
With ammonium acetate; methanol; magnesium; palladium on activated charcoal at 20℃; for 1h;97%
2-acetoxy-5-chloro-3,6-diisopropylpyrazine
87386-72-9

2-acetoxy-5-chloro-3,6-diisopropylpyrazine

aniline
62-53-3

aniline

A

5-chloro-3,6-diisopropyl-2-hydroxypyrazine
87386-78-5

5-chloro-3,6-diisopropyl-2-hydroxypyrazine

B

Acetanilid
103-84-4

Acetanilid

Conditions
ConditionsYield
In benzene for 15h; Ambient temperature;A n/a
B 98%
In benzene for 15h; Product distribution; Ambient temperature;A n/a
B 98%
...Expand
Acetanilid
103-84-4

Acetanilid

4-Acetamido-1-iodobenzene
622-50-4

4-Acetamido-1-iodobenzene

Conditions
ConditionsYield
With 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione; 4,4'-dimethoxyphenyl disulfide In acetonitrile at 20℃; for 0.5h; Catalytic behavior; Reagent/catalyst; Solvent; regioselective reaction;100%
With In(OSO2CF3)3; Iodine monochloride In dichloromethane; acetonitrile at 20℃; for 0.5h;99%
With trichloroisocyanuric acid; iodine In acetonitrile at 20℃; regioselective reaction;99%
Acetanilid
103-84-4

Acetanilid

4-bromoacetanilide
103-88-8

4-bromoacetanilide

Conditions
ConditionsYield
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; 4,4'-dimethoxyphenyl disulfide In acetonitrile at 20℃; for 0.166667h; Reagent/catalyst;100%
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; 4,4'-dimethoxyphenyl disulfide In acetonitrile at 20℃; for 0.166667h;100%
With methanol; tetraethylammonium chloride; bromine In dichloromethane at 35℃;99%
N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

Acetanilid
103-84-4

Acetanilid

N1,N1-dimethyl-N2-phenylformamidine
1783-25-1

N1,N1-dimethyl-N2-phenylformamidine

Conditions
ConditionsYield
With trichlorophosphate for 4h; Heating;100%
With trichlorophosphate In toluene at 90℃; for 2h;89%
4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

Acetanilid
103-84-4

Acetanilid

N-(2-(4-chlorobenzoyl)phenyl)acetamide
92433-53-9

N-(2-(4-chlorobenzoyl)phenyl)acetamide

Conditions
ConditionsYield
With tert.-butylhydroperoxide; palladium diacetate; sodium dodecyl sulfate; trifluoroacetic acid In water at 20℃; for 24h; regioselective reaction;100%
With tert.-butylhydroperoxide; sodium dodecyl-sulfate; palladium diacetate; trifluoroacetic acid In water at 20℃; for 24h;97%
With tert.-butylhydroperoxide; palladium(II) trifluoroacetate In toluene at 20 - 90℃;81%
boron trifluoride diethyl etherate
109-63-7

boron trifluoride diethyl etherate

Acetanilid
103-84-4

Acetanilid

C8H9BF3NO

C8H9BF3NO

Conditions
ConditionsYield
In toluene Reflux;100%
Acetanilid
103-84-4

Acetanilid

4-Phenylbutyric acid
1821-12-1

4-Phenylbutyric acid

N-acetyl-N-4-diphenylbutanamide

N-acetyl-N-4-diphenylbutanamide

Conditions
ConditionsYield
With 2,6-dimethylpyridine; dmap; di-tert-butyl dicarbonate In acetonitrile at 20 - 28℃; for 24h; Inert atmosphere;100%
Acetanilid
103-84-4

Acetanilid

N-(4-chlorophenyl)acetamide
539-03-7

N-(4-chlorophenyl)acetamide

Conditions
ConditionsYield
With N-chloro-N-(benzenesulfonyl)benzenesulfonamide In acetonitrile at 20 - 25℃; for 0.166667h; Green chemistry;99.9%
With hydrogenchloride; 1-chloro-2,2,6,6-tetramethylpiperidine In benzene at 50 - 60℃;92%
With sodium perborate; potassium chloride; sodium tungstate In acetic acid at 20℃; for 1.08333h; Chlorination;86%
Acetanilid
103-84-4

Acetanilid

N-(4-Nitrophenyl)acetamide
104-04-1

N-(4-Nitrophenyl)acetamide

Conditions
ConditionsYield
With sodium nitrate; sulfuric acid at 0 - 5℃; for 3h;99%
With ammonium molybdate; water; nitric acid In chloroform for 6h; Nitration; Heating;99%
With nitric acid; cetyltrimethylammonim bromide In acetonitrile at 24.84℃; for 2h; Micellar solution; regioselective reaction;85%
2-methoxybenzo[d][1,3]dithiole
53301-48-7

2-methoxybenzo[d][1,3]dithiole

Acetanilid
103-84-4

Acetanilid

A

dibenzotetrathiafulvalene
24648-13-3

dibenzotetrathiafulvalene

B

N-Benzo[1,3]dithiol-2-yl-N-phenyl-acetamide
103214-93-3

N-Benzo[1,3]dithiol-2-yl-N-phenyl-acetamide

Conditions
ConditionsYield
With trichloroacetic acid In benzene for 9h; Heating;A n/a
B 99%
...Expand
Acetanilid
103-84-4

Acetanilid

3-Chloro-2-methylpropene
563-47-3

3-Chloro-2-methylpropene

N-(2-methylprop-2-ene-1-yl)-N-phenylacetamide
102860-03-7

N-(2-methylprop-2-ene-1-yl)-N-phenylacetamide

Conditions
ConditionsYield
With sodium hydroxide; tetrabutylammomium bromide In toluene at 75℃; for 2.25h;99%
With tetrabutylammomium bromide; potassium carbonate; sodium hydroxide In toluene at 75℃;85%
Acetanilid
103-84-4

Acetanilid

diphenyl acetylene
501-65-5

diphenyl acetylene

1-(2,3-diphenyl-1H-indol-1-yl)ethan-1-one
1239-56-1

1-(2,3-diphenyl-1H-indol-1-yl)ethan-1-one

Conditions
ConditionsYield
With silver hexafluoroantimonate; dichloro[1,3-di(ethoxycarbonyl)-2,4,5-trimethylcyclopentadienyl]rhodium(III) dimer; copper diacetate In acetone at 20℃; for 16h;99%
With silver hexafluoroantimonate; dichloro[1,3-di(ethoxycarbonyl)-2,4,5-trimethylcyclopentadienyl]rhodium(III) dimer; copper(II) acetate monohydrate In acetone at 20℃; for 72h; Reagent/catalyst; Sealed tube;99%
With silver hexafluoroantimonate; rhodium(III) trichloride hydrate; 2-[4,6-diphenyl-1H-cyclopenta[c]furan-5(3H)-ylidene]-N-phenylacetamide; copper(II) acetate monohydrate In ethanol; acetone at 20℃; for 40h; Catalytic behavior; Reagent/catalyst; Time; Schlenk technique; Inert atmosphere; Sealed tube;99%

Acetanilide Consensus Reports

ACETANILIDE is reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Acetanilide Specification

The Acetanilide, with the CAS registry number 103-84-4 and EINECS registry number 203-150-7, has the systematic name of N-phenylacetamide, and it is also known as Antifebrin. It is an odourless solid chemical of leaf or flake-like appearance, and the pure crystals are plate shaped and colorless to white. It is slightly soluble in water, and stable under most conditions. The molecular formula of this chemical is C8H9NO.

The physical properties of Acetanilide are as followings: (1)ACD/LogP: 1.08; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.08; (4)ACD/LogD (pH 7.4): 1.08; (5)ACD/BCF (pH 5.5): 3.91; (6)ACD/BCF (pH 7.4): 3.91; (7)ACD/KOC (pH 5.5): 92.44; (8)ACD/KOC (pH 7.4): 92.44; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 20.31 Å2; (13)Index of Refraction: 1.575; (14)Molar Refractivity: 40.52 cm3; (15)Molar Volume: 122.5 cm3; (16)Polarizability: 16.06×10-24cm3; (17)Surface Tension: 41.5 dyne/cm; (18)Density: 1.103 g/cm3; (19)Flash Point: 173.9 °C; (20)Enthalpy of Vaporization: 54.49 kJ/mol; (21)Boiling Point: 304.5 °C at 760 mmHg; (22)Vapour Pressure: 0.000871 mmHg at 25°C.

Preparation of Acetanilide: It can be prepared by reacting acetic anhydride with aniline: 
C6H5NH2 + (CH3CO)2O → C6H5NHCOCH3 + CH3COOH

Applictions of Acetanilide: It is often used as an inhibitor in hydrogen peroxide to stabilize cellulose ester varnishes. It is also used in the intermediation in rubber accelerator synthesis, dyes and dye intermediate synthesis, camphor synthesis and so on. It is used for the production of 4-acetamidobenzenesulfonyl chloride, a key intermediate for the manufacture of the sulfa drugs as well. What's more, it is also a precursor in the synthesis of penicillin and other pharmaceuticals.

You should be cautious while dealing with this chemical. It irritates to eyes, respiratory system and skin, and it is also harmful if swallowed. Therefore, you had better take the following instructions: Do not breathe dust; Wear suitable protective clothing, gloves and eye/face protection, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.
 
You can still convert the following datas into molecular structure:
(1)SMILES: O=C(Nc1ccccc1)C
(2)InChI: InChI=1/C8H9NO/c1-7(10)9-8-5-3-2-4-6-8/h2-6H,1H3,(H,9,10)
(3)InChIKey: FZERHIULMFGESH-UHFFFAOYAA

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 8500ug/kg (8.5mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 30, Pg. 91, 1941.
cat LDLo oral 250mg/kg (250mg/kg)   Journal of the American Pharmaceutical Association. Vol. 28, Pg. 70, 1939.
dog LDLo intravenous 300mg/kg (300mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1290, 1935.
dog LDLo oral 500mg/kg (500mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1290, 1935.
guinea pig LDLo oral 200mg/kg (200mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1290, 1935.
human TDLo oral 14mg/kg/D (14mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN		 "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 62, 1969.
man LDLo oral 56mg/kg/H-I (56mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

GASTROINTESTINAL: DECREASED MOTILITY OR CONSTIPATION		 American Journal of the Medical Sciences. Vol. 122, Pg. 770, 1901.
man LDLo unreported 59mg/kg (59mg/kg)   "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
man TDLo oral 405mg/kg (405mg/kg) BEHAVIORAL: SLEEP

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 JAMA, Journal of the American Medical Association. Vol. 12, Pg. 103, 1889.
mouse LD50 intraperitoneal 500mg/kg (500mg/kg)   National Technical Information Service. Vol. AD277-689,
mouse LD50 oral 1210mg/kg (1210mg/kg)   Toxicology and Applied Pharmacology. Vol. 19, Pg. 20, 1971.
rabbit LDLo oral 1500mg/kg (1500mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 466, 1933.
rat LD50 intraperitoneal 540mg/kg (540mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 48, Pg. 204, 1959.
rat LD50 oral 800mg/kg (800mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 54, Pg. 159, 1935.

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