Acetopromazine supplier | CasNO.61-00-7

Name
acepromazine
EINECS
CAS No. 61-00-7
Article Data13
CAS DataBase
Density 1.1075 (rough estimate)
Solubility 16mg/L(25 oC)
Melting Point <25 °C
Formula C19H22 N2 O S
Boiling Point bp0.5 220-240°
Molecular Weight 326.462
Flash Point
Transport Information
Appearance
Safety Poison by ingestion, intravenous, and subcutaneous routes. A flammable liquid. When heated to decomposition it emits toxic fumes of SO_x and NO_x. See also KETONES. An animal tranquilizer.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Ketone,10-[3-(dimethylamino)propyl]phenothiazin-2-yl methyl (8CI);10-(3-Dimethylaminopropyl)phenothiazin-3-yl methyl ketone; 1522CB;2-Acetylpromazine; 3-Acetyl-10-(3-dimethylaminopropyl)phenothiazine;Acepromazin; Acepromazine; Acetacin; Acetazin; Acetazine; Acetopromazine;Acetylpromazine; Azepromazine; CC 64; Placivet; Plegicil; Plivafen; Vetranquil
PSA 48.85000
LogP 4.50860

Synthetic route

: 1219602-22-8
C13H19IN2O

: 6320-02-1
2-bromothiophenol

: 61-00-7
acetopromazine

Conditions

Conditions	Yield
With copper(l) iodide; potassium carbonate; L-proline In ethyl methyl ether at 90 - 110℃; Inert atmosphere;	75%

: 6631-94-3
2-acetylphenothiazine

: 109-54-6
3-(Dimethylamino)propyl chloride

: 61-00-7
acetopromazine

Conditions

Conditions	Yield
Stage #1: 2-acetylphenothiazine With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: 3-(Dimethylamino)propyl chloride In N,N-dimethyl-formamide at 50℃; for 5h;	22%
With sodium hydride

: 59995-97-0
2-acetyl-phenothiazine-10-carboxylic acid 3-dimethylamino-propyl ester

: 61-00-7
acetopromazine

Conditions

Conditions	Yield
oder unter vermindertem Druck;
With copper; 1,3-Dimethoxybenzene

: 39481-55-5
2-acetyl-10-(3'-chloropropyl)-10H-phenothiazine

: 124-40-3
dimethyl amine

: 61-00-7
acetopromazine

Conditions

Conditions	Yield
In ethanol

: 109-54-6
3-(Dimethylamino)propyl chloride

lithium-compound of 2-<2-methyl-<1,3>dioxolan-2-yl>-phenothiazine: lithium-compound of 2-<2-methyl-<1,3>dioxolan-2-yl>-phenothiazine

: 61-00-7
acetopromazine

: 89-98-5
2-chloro-benzaldehyde

: 61-00-7
acetopromazine

: (E)-3-(2-chlorophenyl)-1-(10-(3-(dimethylamino)propyl)-10H-phenothiazin-2-yl)-3-phenylprop-2-en-1-one

Conditions

Conditions	Yield
Stage #1: 2-chloro-benzaldehyde; acetopromazine With sodium ethanolate In ethanol Cooling with ice; Sonication; Stage #2: With hydrogenchloride pH=5 - 7;	81%

: 104-88-1
4-chlorobenzaldehyde

: 61-00-7
acetopromazine

: (E)-3-(4-chlorophenyl)-1-(10-(3-(dimethylamino)propyl)-10H-phenothiazin-2-yl)-3-phenylprop-2-en-1-one

Conditions

Conditions	Yield
Stage #1: 4-chlorobenzaldehyde; acetopromazine With sodium ethanolate In ethanol Cooling with ice; Sonication; Stage #2: With hydrogenchloride pH=5 - 7;	78%

: 61-00-7
acetopromazine

: 100-52-7
benzaldehyde

: (E)-1-(10-(3-(dimethylamino)propyl)-10H-phenothiazin-2-yl)-3-phenylprop-2-en-1-one

Conditions

Conditions	Yield
Stage #1: acetopromazine; benzaldehyde With sodium ethanolate In ethanol Cooling with ice; Sonication; Stage #2: With hydrogenchloride pH=5 - 7;	68%

: 61-00-7
acetopromazine

: 874-42-0
2,4-dichlorobenzaldeyhde

: (E)-3-(2,4-dichlorophenyl)-1-(10-(3-(dimethylamino)propyl)-10H-phenothiazin-2-yl)-3-phenylprop-2-en-1-one

Conditions

Conditions	Yield
Stage #1: acetopromazine; 2,4-dichlorobenzaldeyhde With sodium ethanolate In ethanol Cooling with ice; Sonication; Stage #2: With hydrogenchloride pH=5 - 7;	62%

: 447-61-0
2-Trifluoromethylbenzaldehyde

: 61-00-7
acetopromazine

: (E)-1-(10-(3-((dimethylamino)propyl)-10H-phenothiazin-2-yl)-3-(2-triuoromethyl)phenyl)prop-2-en-1-one

Conditions

Conditions	Yield
Stage #1: 2-Trifluoromethylbenzaldehyde; acetopromazine With sodium ethanolate In ethanol Cooling with ice; Sonication; Stage #2: With hydrogenchloride pH=5 - 7;	58%

: 459-57-4
4-fluorobenzaldehyde

: 61-00-7
acetopromazine

: (E)-1-(10-(3-(dimethylamino)propyl)-10H-phenothiazin-2-yl)-3-(4-fluorophenyl)prop-2-en-1-one

Conditions

Conditions	Yield
Stage #1: 4-fluorobenzaldehyde; acetopromazine With sodium ethanolate In ethanol Cooling with ice; Sonication; Stage #2: With hydrogenchloride pH=5 - 7;	57%

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 61-00-7
acetopromazine

: (E)-1-(10-(3-(dimethylamino)propyl)-10H-phenothiazin-2-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one

Conditions

Conditions	Yield
Stage #1: 3,4,5-trimethoxy-benzaldehyde; acetopromazine With sodium ethanolate In ethanol Cooling with ice; Sonication; Stage #2: With hydrogenchloride pH=5 - 7;	51%

: 3132-99-8
m-bromobenzoic aldehyde

: 61-00-7
acetopromazine

: (E)-3-(3-bromophenyl)-1-(10-(3-(dimethylamino)propyl)-10H-phenothiazin-2-yl)-3-phenylprop-2-en-1-one

Conditions

Conditions	Yield
Stage #1: m-bromobenzoic aldehyde; acetopromazine With sodium ethanolate In ethanol Cooling with ice; Sonication; Stage #2: With hydrogenchloride pH=5 - 7;	51%

: 61-00-7
acetopromazine

: 591-31-1
3-methoxy-benzaldehyde

: (E)-1-(10-(3-(dimethylamino)propyl)-10H-phenothiazin-2-yl)-3-(3-methoxyphenyl)prop-2-en-1-one

Conditions

Conditions	Yield
Stage #1: acetopromazine; 3-methoxy-benzaldehyde With sodium ethanolate In ethanol Cooling with ice; Sonication; Stage #2: With hydrogenchloride pH=5 - 7;	43%

: 387-45-1
2-chloro-6-fluorobenzaldehyde

: 61-00-7
acetopromazine

: (E)-3-(2-chloro-6-uorophenyl)-1-(10-(3-(dimethylamino)propyl)-10H-phenothiazin-2-yl)-3-phenylprop-2-en-1-one

Conditions

Conditions	Yield
Stage #1: 2-chloro-6-fluorobenzaldehyde; acetopromazine With sodium ethanolate In ethanol Cooling with ice; Sonication; Stage #2: With hydrogenchloride pH=5 - 7;	43%

: 61-00-7
acetopromazine

: 123-11-5
4-methoxy-benzaldehyde

: (E)-1-(10-(3-(dimethylamino)propyl)-10H-phenothiazin-2-yl)-3-(4-methoxyphenyl)prop-2-en-1-one

Conditions

Conditions	Yield
Stage #1: acetopromazine; 4-methoxy-benzaldehyde With sodium ethanolate In ethanol Cooling with ice; Sonication; Stage #2: With hydrogenchloride pH=5 - 7;	41%

: 4397-53-9
p-benzyloxybenzaldehyde

: 61-00-7
acetopromazine

: (E)-3-(4-(benzyloxy)phenyl)-1-(10-(3-(dimethylamino)propyl)-10H-phenothiazin-2-yl)-3-phenylprop-2-en-1-one

Conditions

Conditions	Yield
Stage #1: p-benzyloxybenzaldehyde; acetopromazine With sodium ethanolate In ethanol Cooling with ice; Sonication; Stage #2: With hydrogenchloride pH=5 - 7;	40%

: 61-00-7
acetopromazine

: 100-10-7
4-dimethylamino-benzaldehyde

: (E)-3-(4-(dimethylamino)phenyl)-1-(10-(3-(dimethylamino)propyl)-10H-phenothiazin-2-yl)-3-phenylprop-2-en-1-one

Conditions

Conditions	Yield
Stage #1: acetopromazine; 4-dimethylamino-benzaldehyde With sodium ethanolate In ethanol Cooling with ice; Sonication; Stage #2: With hydrogenchloride pH=5 - 7;	39%

: 23834-14-2
7-chloro-4-hydrazinoquinoline

: 61-00-7
acetopromazine

: (E)-3-(2-(1-(2-(7-chloroquinolin-4-yl)hydrazono)ethyl)-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine

Conditions

Conditions	Yield
With acetic acid In ethanol for 24h; Reflux;	35%

: 61-00-7
acetopromazine

: 73644-43-6
1-[10-(3-dimethylamino-propyl)-phenothiazin-2-yl]-ethanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; diethyl ether

: 917-54-4
methyllithium

: 61-00-7
acetopromazine

: 20828-92-6
2-[10-(3-dimethylamino-propyl)-10H-phenothiazin-2-yl]-propan-2-ol

Conditions

Conditions	Yield
In diethyl ether

: 1066-26-8
sodium acetylide

: 61-00-7
acetopromazine

: 110147-41-6
2-[10-(3-dimethylamino-propyl)-10H-phenothiazin-2-yl]-but-3-yn-2-ol

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at -14 - 20℃; for 2.5h;

: 608-05-9
5-methyl-indole-2,3-dione

: 61-00-7
acetopromazine

: 64290-13-7
2-[10-(3-dimethylamino-propyl)-10H-phenothiazin-2-yl]-6-methyl-quinoline-4-carboxylic acid

Conditions

Conditions	Yield
With potassium hydroxide In 1,4-dioxane; ethanol; water for 24h; Heating;

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 61-00-7
acetopromazine

: 64290-12-6
2-[10-(3-dimethylamino-propyl)-10H-phenothiazin-2-yl]-6-fluoro-quinoline-4-carboxylic acid

Conditions

Conditions	Yield
With potassium hydroxide In 1,4-dioxane; ethanol; water for 24h; Heating;

: 39755-95-8
5-methoxyisatine

: 61-00-7
acetopromazine

: 64290-14-8
2-[10-(3-dimethylamino-propyl)-10H-phenothiazin-2-yl]-6-methoxy-quinoline-4-carboxylic acid

Conditions

Conditions	Yield
With potassium hydroxide In 1,4-dioxane; ethanol; water for 24h; Heating;

: 91-56-5
indole-2,3-dione

: 61-00-7
acetopromazine

: 64290-11-5
2-[10-(3-dimethylamino-propyl)-10H-phenothiazin-2-yl]-quinoline-4-carboxylic acid

Conditions

Conditions	Yield
With potassium hydroxide In 1,4-dioxane; ethanol; water for 24h; Heating;

: 17630-76-1
5-chloroindole 2,3-dione

: 61-00-7
acetopromazine

: 64323-68-8
6-chloro-2-[10-(3-dimethylamino-propyl)-10H-phenothiazin-2-yl]-quinoline-4-carboxylic acid

Conditions

Conditions	Yield
With potassium hydroxide In 1,4-dioxane; ethanol; water for 24h; Heating;

: 593-56-6
N-methoxylamine hydrochloride

: 61-00-7
acetopromazine

: 1-[10-(3-Dimethylamino-propyl)-10H-phenothiazin-2-yl]-ethanone O-methyl-oxime

Conditions

Conditions	Yield
With pyridine

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 61-00-7
acetopromazine

: 1-[10-(3-Dimethylamino-propyl)-10H-phenothiazin-2-yl]-ethanone O-benzyl-oxime

Conditions

Conditions	Yield
With pyridine

Acetopromazine Chemical Properties

Molecular Structure of Acetopromazine (CAS NO.61-00-7):

IUPAC Name: 1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]ethanone
Empirical Formula: C₁₉H₂₂N₂OS
Molecular Weight: 326.4558
Index of Refraction: 1.609
Surface Tension: 45.4 dyne/cm
Density: 1.155 g/cm³
Flash Point: 254.4 °C
Enthalpy of Vaporization: 76.49 kJ/mol
Boiling Point: 497 °C at 760 mmHg
Vapour Pressure: 5.13E-10 mmHg at 25°C
Synonyms of Acetopromazine (CAS NO.61-00-7): acepromazine ; 10-[3-[Dimethylamino] propyl] phenothiazin-2-yl methyl ketone ; Acetylpromazine;Ethanone, 1-10-3-(dimethylamino)propyl-10H-phenothiazin-2-yl-;KETONEketone,10-(3-(dimethylamino)propyl)phenothiazin-2-ylmethyl ; 10-(3-dimethylaminopropyl)phenothiazine-3ethylone ; Acepromazine (base and/or unspecified salts) ; 1-[10-(3-dimethylaminopropyl)phenothiazin-2-yl]ethanone

Acetopromazine Toxicity Data With Reference

1.	ipr-rat LD50:140 mg/kg	FATOAO Farmakologiya i Toksikologiya (Moscow). 24 (1961),136.
2.	orl-mus LDLo:200 mg/kg	AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 113 (1957),53.
3.	ipr-mus LD50:350 mg/kg	RMNIBN Revista Medico-Chirurgicala. 81 (1977),105.
4.	scu-mus LD50:130 mg/kg	AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 113 (1957),53.
5.	ivn-mus LD50:59 mg/kg	AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 115 (1958),1.

Acetopromazine Safety Profile

Poison by ingestion, intravenous, and subcutaneous routes. A flammable liquid. When heated to decomposition it emits toxic fumes of SO_x and NO_x. See also KETONES. An animal tranquilizer.

Acetopromazine Standards and Recommendations

DOT Classification: 3; Label: Flammable Liquid

Acetopromazine Specification

Acetopromazine (CAS NO.61-00-7) is an orange yellow oily liquid. Boiling point is 220-240 ℃ (66.5Pa),its maleate yellow crystal, melting point is 135-136 ℃, soluble in water, 0.1% of the aqueous solution pH is 5.2, no foul and bitter taste, flammable,thermal decomposition would release toxic fumes of nitrogen oxides and sulfur oxides,it should be stored in low temperature, ventilation, drying environmental conditions,separated with food and raw materials, besides water, carbon oxides and oxidation of toxic carbon dioxide, dry powder, sand, water mist fire extinguishing agent can be used if emergency.
Its use is similar with chlorpromazine , but stable activity is weaker than chlorpromazine , poorer treatment outcomes. Used for sedation, anti-psychotic, antiemetic, analgesic and anti-convulsive and so on. And analgesics, hypnotics, local anesthetics such as in combination can strengthen its role. Be connection with pethidine, promethazine combination agent for the artificial hibernation.

Product Name

acepromazine

Synthetic route

Acetopromazine Chemical Properties

Acetopromazine Toxicity Data With Reference

Acetopromazine Safety Profile

Acetopromazine Standards and Recommendations

Acetopromazine Specification

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