Chlorocyclohexane supplier

Name
Chlorocyclohexane
EINECS 208-806-6
CAS No. 542-18-7
Article Data304
CAS DataBase
Density 1 g/mL at 25 °C(lit.)
Solubility 0.02 g/L (20 ºC)
Melting Point - 44 °C
Formula C₆H₁₁Cl
Boiling Point 142 °C at 760 mmHg
Molecular Weight 118.606
Flash Point 28.9 °C
Transport Information UN 1993 3/PG 3
Appearance clear liquid
Safety 26-36-37/39-16
Risk Codes 10-36/37/38-20
Molecular Structure
Hazard Symbols Xi,Xn
Synonyms chlor-cyclohexane;4-05-00-00048 (Beilstein Handbook Reference);1/C6H11Cl/c7-6-4-2-1-3-5-6/h6H,1-5H;cyclohexane, chloro-;Monochlorocyclohexane;Cyclohexyl Chloride;
PSA 0.00000
LogP 2.55790

Synthetic route

: 32308-83-1
nonafluoro-tert-butanesulfenyl chloride

: 110-82-7
cyclohexane

A: 32308-82-0
nonafluoro-tert-butanethiol

B: 542-18-7
cyclohexyl chloride

Conditions

Conditions	Yield
	A 100% B 100%
	A 100% B 100%

...Expand

: 108-93-0
cyclohexanol

: 542-18-7
cyclohexyl chloride

Conditions

Conditions	Yield
With bismuth(III) chloride In tetrachloromethane for 0.0833333h; Heating;	99%
With 1,2,3-Benzotriazole; thionyl chloride In dichloromethane at 20℃; Substitution;	92%
With triphenylphosphine; zinc(II) chloride; diethylazodicarboxylate In tetrahydrofuran for 2h; Ambient temperature;	90%

: 626-62-0
1-iodocyclohexane

: 542-18-7
cyclohexyl chloride

Conditions

Conditions	Yield
With bismuth(III) chloride In 1,2-dichloro-ethane for 0.25h; Heating;	98%

: 110-82-7
cyclohexane

: 542-18-7
cyclohexyl chloride

Conditions

Conditions	Yield
With hydrogenchloride; tetrabutyl-ammonium chloride; sodium chloride In water at 20℃; for 5h; Reagent/catalyst;	97%
With hydrogenchloride; potassium chloride; tetrabutyl-ammonium chloride In water at 20℃; Irradiation; Green chemistry;	95%
With sodium hypochlorite In water; acetone at 20℃; for 2h; Reagent/catalyst; Solvent; Time; Inert atmosphere;	93%

: 110-82-7
cyclohexane

: 2712-93-8
dichlorofluoromethanesulphenyl chloride

A: 542-18-7
cyclohexyl chloride

B: 675-63-8
bis(dichlorofluoromethyl)disulfane

C: 68409-02-9
Dichlorfluormethyl-cyclohexylsulfid

Conditions

Conditions	Yield
	A 63.6% B 97% C 3%
	A 63.6% B 97% C 3%

...Expand

: 110-83-8
cyclohexene

: 542-18-7
cyclohexyl chloride

Conditions

Conditions	Yield
With ethanol; trichlorovinylsilane; tin(IV) chloride for 1h; Ambient temperature;	90%
With dichloromethane; RhCl(PPh3)3	72%
With chloro-trimethyl-silane; water for 15h; Ambient temperature;	70%

: 372-46-3
fluorocyclohexane

: 542-18-7
cyclohexyl chloride

Conditions

Conditions	Yield
With hydrogenchloride at 105℃; for 3h;	90%
With boron trichloride In hexane at 0℃; for 0.0833333h;	78%
With diethylaluminium chloride In hexane at -78℃; for 0.166667h;	74 % Chromat.

: 108-93-0
cyclohexanol

A: 1499-17-8
o-phenylene chlorophosphate

B: 542-18-7
cyclohexyl chloride

Conditions

Conditions	Yield
With CPT	A n/a B 90%

: 993-38-4
chlorodifluoromethansulfenylchloride

: 110-82-7
cyclohexane

A: 542-18-7
cyclohexyl chloride

B: 692-58-0
bis(chlorodifluoromethyl)disulfane

C: 68409-01-8
(Chloro-difluoro-methylsulfanyl)-cyclohexane

D: 68409-06-3
benzyl chloro-difluoromethyl sulfide

Conditions

Conditions	Yield
	A 39.4% B 88.4% C 11.6% D 65%
	A 39.4% B 88.4% C 11.6% D 65%

...Expand

: 1,3-dioxoisoindolin-2-yl cyclohexanecarboxylate

: 542-18-7
cyclohexyl chloride

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane; tetrachloromethane In water; tert-butyl alcohol for 4h; Irradiation;	86%

: 662-42-0
heptafluoro-propane-1-sulphenic acid chloride

: 110-82-7
cyclohexane

A: 356-07-0
bis(perfluoro-n-propyl)disulfane

B: 542-18-7
cyclohexyl chloride

C: 68409-00-7
heptafluoro-n-propyl cyclohexyl sulfide

Conditions

Conditions	Yield
	A 85.7% B 43.2% C 14.3%
	A 85.7% B 43.2% C 14.3%
for 0.1h; Mechanism; Irradiation; effect of bis(trifluoromethyl) disulfide;

...Expand

: 931-56-6
2-methoxycyclohexane

A: 542-18-7
cyclohexyl chloride

B: 101-41-7
benzeneacetic acid methyl ester

Conditions

Conditions	Yield
With phenylacetyl chloride; zinc In Petroleum ether at 28℃; for 4h; Yields of byproduct given;	A 84% B n/a

: 931-56-6
2-methoxycyclohexane

: 103-80-0
phenylacetyl chloride

A: 542-18-7
cyclohexyl chloride

B: 101-41-7
benzeneacetic acid methyl ester

Conditions

Conditions	Yield
With zinc In Petroleum ether at 28℃; for 4h; Yields of byproduct given;	A n/a B 84%

...Expand

: 108-93-0
cyclohexanol

A: 542-18-7
cyclohexyl chloride

B: 110-83-8
cyclohexene

Conditions

Conditions	Yield
With 1-chloro-1-(dimethylamino)-2-methyl-1-propene In dichloromethane 1.) 0 deg C; 2.) rt., 3h;	A 18 % Spectr. B 82%
With hydrogenchloride
With aluminium trichloride Erwaermen auf dem Dampfbad;

: cyclohexyl o-(N-methylcarbamoyl)phenyl sulphoxide

A: 2527-66-4
2-methyl-1,2-benzisothiazole-3(2H)-one

B: 542-18-7
cyclohexyl chloride

C: 2-chlorocyclohexyl o-(N-methylcarbamoyl)phenyl sulfide

D: 110-83-8
cyclohexene

Conditions

Conditions	Yield
With thionyl chloride In dichloromethane for 1h; Mechanism; Product distribution; Heating; also pyrolysis in toluene, 110 deg C, 20 h, without SOCl2; further o-(N-methylcarbamoyl)phenyl sulphoxides;	A 81% B 11% C 16% D 67%
With thionyl chloride In dichloromethane for 1h; Heating;	A 81% B 11% C 16% D 67%

...Expand

: 33427-17-7
(1R,2R)-1-Chloro-2-iodo-cyclohexane

: 542-18-7
cyclohexyl chloride

Conditions

Conditions	Yield
With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; tri-n-butyl-tin hydride In tetrahydrofuran for 0.25h; Ambient temperature;	80%

: 110-82-7
cyclohexane

: 114541-87-6
benzyloxychlorocarbene

A: 542-18-7
cyclohexyl chloride

B: 100-44-7
benzyl chloride

C: 108-93-0
cyclohexanol

Conditions

Conditions	Yield
at 25℃; Photolysis;	A 9% B 80% C 11%

...Expand

: C20H26OP(1+)*Cl(1-)

A: 542-18-7
cyclohexyl chloride

B: C14H16OP(1+)*Cl(1-)

Conditions

Conditions	Yield
In benzene at 30℃; Kinetics; Solvent; Temperature; Inert atmosphere; Schlenk technique;	A n/a B 70%

: 110-82-7
cyclohexane

: 98-85-1, 13323-81-4
1-Phenylethanol

A: 542-18-7
cyclohexyl chloride

B: 10017-37-5
tert-butylamine hydrochloride

C: 98-86-2
acetophenone

Conditions

Conditions	Yield
With N,N-dichloro-t-butylamine at 20℃; for 1h; Irradiation;	A 68% B n/a C n/a

...Expand

: 108-94-1
cyclohexanone

: 542-18-7
cyclohexyl chloride

Conditions

Conditions	Yield
With dichloromethylsilane; iron(III) chloride In 1,2-dimethoxyethane for 6h; Heating;	66%
Multi-step reaction with 2 steps 1: diethyl ether; sodium; alcohol / Reagens 4: Kaliumcarbonat 2: fuming hydrochloric acid / 100 °C View Scheme
Stage #1: cyclohexanone With iron(III) chloride In ethyl acetate at 20℃; for 0.0166667h; Stage #2: With dimethylmonochlorosilane In ethyl acetate at 20℃;

: 110-82-7
cyclohexane

: 51031-50-6
heptafluoropropane-2-sulphenic acid chloride

A: 542-18-7
cyclohexyl chloride

B: 754-62-1
bis(perfluoroisopropyl) disulfide

C: 68408-97-9
heptafluoropropane-2-thiol

D: 68408-99-1
Heptafluorisopropylcyclohexylsulfid

Conditions

Conditions	Yield
	A 37.7% B 65% C n/a D 0.5%
	A 37.7% B 65% C n/a D 0.5%

...Expand

: 98-07-7
Benzotrichlorid

: 108-93-0
cyclohexanol

A: 98-87-3
benzylidene dichloride

B: 542-18-7
cyclohexyl chloride

Conditions

Conditions	Yield
With TOP; phenylsilane In neat (no solvent) at 100℃; for 24h; Appel Halogenation; Inert atmosphere;	A n/a B 57%

...Expand

: 110-82-7
cyclohexane

A: 542-18-7
cyclohexyl chloride

B: 108-93-0
cyclohexanol

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; (FeCl2(C6H6N2CO)(CH3)2(C5H4N)2(C(O)OCH3)2); tetrabutyl-ammonium chloride In acetonitrile at 25℃; for 0.583333h; Inert atmosphere; chemoselective reaction;	A 5.1% B 55.4%
With [FeIV(1,1-di(pyridin-2-yl)-N,N-bis(quinolin-2-ylmethyl)methanamine)(O)]2+; [FeII(1,1-di(pyridin-2-yl)-N,N-bis(quinolin-2-ylmethyl)methanamine)(Cl)]Cl In acetonitrile at 25℃; for 0.5h; Inert atmosphere; Glovebox;	A 52% B n/a
With 5,10,15,20-tetraphenyl-21 H,23-H-porphine manganese(III)chloride; iodosylbenzene In dichloromethane; water for 12h;	A 18% B 30%

: 421-17-0
Trifluoromethylsulfenyl chloride

: 110-82-7
cyclohexane

A: 372-64-5
Bis(trifluoromethyl)disulfid

B: 6476-52-4
cyclohexyl(trifluoromethyl)sulfane

C: 542-18-7
cyclohexyl chloride

Conditions

Conditions	Yield
byproducts: HCl; Irradiation (UV/VIS);	A 35% B 45% C 28%
byproducts: HCl; Irradiation (UV/VIS);	A 35% B 45% C 28%
for 0.2h; Mechanism; Irradiation; effect of bis(heptafluoro-n-propyl) disulfide;

...Expand

: 56-34-8
tetraethylammonium chloride

: 937-14-4
3-chloro-benzenecarboperoxoic acid

A: 542-18-7
cyclohexyl chloride

B: 1128-76-3
3-chloro-benzoic acid ethyl ester

Conditions

Conditions	Yield
With cyclohexane In acetonitrile at 20℃; for 3h; Yields of byproduct given;	A n/a B 38%

...Expand

: 110-82-7
cyclohexane

A: 542-18-7
cyclohexyl chloride

B: 108-94-1
cyclohexanone

C: 108-93-0
cyclohexanol

Conditions

Conditions	Yield
With chloroform; pyrimido<5,4-g>pteridine N-oxide for 3h; Product distribution; Mechanism; Irradiation;	A 11% B 12% C 37%
With [oxoiron(IV)(tris-(quinolyl-2-methyl)amine)(chloride)](1+) In [D3]acetonitrile at -40℃; Reagent/catalyst;	A 35% B 3% C 7%
With barium hexaferrite; acetic acid; magnesium chloride In dichloromethane at 23℃; for 2h; Product distribution; Further Variations:; Reagents;	A 31% B 13% C 10%

...Expand

: 110-82-7
cyclohexane

A: 542-18-7
cyclohexyl chloride

B: 108-94-1
cyclohexanone

Conditions

Conditions	Yield
With potassium permanganate; aluminium trichloride In acetonitrile for 0.5h;	A 35% B 15%
With [oxoiron(IV)(tris(pyridyl-2-methyl)amine)(chloride)](triflate) In [D3]acetonitrile at 25℃; Inert atmosphere;	A 11% B 2%
With cis-VI(6,6'-Cl2bpy)2O2> In tetrachloromethane; acetonitrile at 20℃; for 0.5h; Oxidation;	A 0.5 % Chromat. B 50 % Chromat.
With peracetic acid; triethylamine hydrochloride; acetic acid In acetonitrile at 22℃; Inert atmosphere; sealed system;

: 56-23-5
tetrachloromethane

: 110-83-8
cyclohexene

A: 542-18-7
cyclohexyl chloride

: 7484-12-0, 55756-67-7, 62435-49-8
trans-1-trichloromethyl-2-chlorocyclohexane

: trans-1-hydroxy-2-trichloromethylcyclohexane

Conditions

Conditions	Yield
With tris(triphenylphosphine)ruthenium(II) chloride; water at 150℃; for 6h; Autoclave;	A n/a B 25% C 25%

...Expand

: 110-82-7
cyclohexane

A: 542-18-7
cyclohexyl chloride

B: 15619-54-2
tert-butyl cyclohexyl peroxide

C: 108-94-1
cyclohexanone

D: 108-93-0
cyclohexanol

Conditions

Conditions	Yield
With Co(III)(BPI)(OAc)(OO-tBu) at 60℃; for 2h; Product distribution; stoichiometric oxidation by various cobalt(III)alkylperoxy complexes, solvents;	A n/a B 18% C 24% D 18%

...Expand

: 75-91-2
tert.-butylhydroperoxide

: 110-82-7
cyclohexane

: 107-13-1
acrylonitrile

A: 542-18-7
cyclohexyl chloride

B: 75354-09-5
2-Chlor-3-cyclohexylpropiononitril

C: 158750-03-9
2-tert-Butylperoxy-3-cyclohexyl-propionitrile

Conditions

Conditions	Yield
With acetic acid; ferric nitrate; copper dichloride In pyridine at 60℃; Product distribution; Mechanism; further with LiCl;	A 15.8% B 8.7% C 3.1%

...Expand

: 542-18-7
cyclohexyl chloride

: 108-85-0
1-bromocyclohexane

Conditions

Conditions	Yield
With hydrogen bromide; ferric(III) bromide In dichloromethane at 25℃; for 0.3h;	99%
With hydrogen bromide at 105℃; for 4h;	90%
With ferric(III) bromide; hydrogen bromide In dichloromethane at 25℃; for 2h;
With hydrogen bromide; cetyltributylphosphonium bromide at 105℃; for 7h;	80 % Chromat.
With ferric(III) bromide; hydrogen bromide In dichloromethane at 25℃; for 0.3h; Product distribution; Mechanism; other alkyl chlorides; other hydrogen halide; also without HBr; var. reaction conditions;	99 % Chromat.

: 542-18-7
cyclohexyl chloride

: 15769-84-3
N-<(S)-1-phenylethyl>-2-pyridinecarboxamide

: 3-cyclohexyl-N-(1-phenylethyl)picolinamide

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; ethylmagnesium bromide; manganese(ll) chloride In tetrahydrofuran at 60℃; for 14h; Catalytic behavior; Reagent/catalyst; Schlenk technique; Inert atmosphere; chemoselective reaction;	99%

: 542-18-7
cyclohexyl chloride

: 13139-86-1
4-methoxyphenyl magnesium bromide

: 613-36-5
4-cyclohexylanisole

Conditions

Conditions	Yield
With iron(III) chloride; N,N′-bis(2,6-diisopropylphenyl)imidazol-2-ylidene hydrochloride In tetrahydrofuran at 0 - 40℃; for 1.66667h;	98%
Stage #1: cyclohexyl chloride With [1,3-bis(3,5-di-tert-butyl-2-hydroxybenzyl)benzimidazolium][FeCl4] In diethyl ether at 0℃; for 0.0333333h; Schlenk technique; Inert atmosphere; Stage #2: 4-methoxyphenyl magnesium bromide In diethyl ether at 0 - 30℃; for 2h; Temperature; Schlenk technique; Inert atmosphere;	86%
With iron(III) chloride; triethylamine In diethyl ether for 0.5h; Grignard cross-coupling reaction; Heating;

: N(C4H9)4(1+)*Cu(1+)*2CN(1-)=(N(C4H9)4)[Cu(CN)2]

: 542-18-7
cyclohexyl chloride

: 766-05-2
cyclohexane carbonitrile

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide In acetonitrile at 20℃; for 4h; Reagent/catalyst; Inert atmosphere; UV-irradiation;	98%

: 542-18-7
cyclohexyl chloride

: 71-43-2
benzene

: 7325-14-6
1,3,5-tricyclohexylbenzene

Conditions

Conditions	Yield
With aluminum (III) chloride at 0 - 20℃; for 4h; Friedel-Crafts Alkylation;	95%
With aluminum (III) chloride at 3 - 20℃;

: 542-18-7
cyclohexyl chloride

: 352-13-6
4-flourophenylmagnesium bromide

: 1717-84-6
1-cyclohexyl-4-fluorobenzene

Conditions

Conditions	Yield
With iron(III) chloride; N,N′-bis(2,6-diisopropylphenyl)imidazol-2-ylidene hydrochloride In tetrahydrofuran at 0 - 40℃; for 1.66667h;	95%
Stage #1: cyclohexyl chloride With [1,3-bis(3,5-di-tert-butyl-2-hydroxybenzyl)benzimidazolium][FeCl4] In diethyl ether at 0℃; for 0.0333333h; Schlenk technique; Inert atmosphere; Stage #2: 4-flourophenylmagnesium bromide In diethyl ether at 0 - 30℃; for 2h; Temperature; Schlenk technique; Inert atmosphere;	78%

: 542-18-7
cyclohexyl chloride

: 1521266-22-7
1-(4-butoxyphenyl)-1-cyclohexyl-3-[4-(2,5-dimethylphenyl)piperazin-1-yl]-2-phenylpropan-1-one

Conditions

Conditions	Yield
Stage #1: cyclohexyl chloride With magnesium In diethyl ether Stage #2: With 1-(4-butoxyphenyl)-3-[4-(2,5-dimethylphenyl)piperazin-1-yl]-2-phenylpropan-1-one In diethyl ether for 6h; Heating;	95%

: 542-18-7
cyclohexyl chloride

: 455-18-5
4-CF3C6H4CN

: N-cyclohexyl-4-(trifluoromethyl)benzamide

Conditions

Conditions	Yield
With zinc perchlorate In neat (no solvent) at 80℃; for 3h; Ritter Amidation;	94%
With iron(II) chloride tetrahydrate In neat (no solvent) at 80℃; for 4h; Ritter Amidation;	94%

: 199477-91-3
N-(2-phenylethyl)pyridine-2-carboxamide

: 542-18-7
cyclohexyl chloride

: 3-cyclohexyl-N-phenylethylpicolinamide

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; ethylmagnesium bromide; manganese(ll) chloride In tetrahydrofuran at 60℃; for 14h; Schlenk technique; Inert atmosphere; chemoselective reaction;	94%

: 873-73-4
4-n-chlorophenylacetylene

: 542-18-7
cyclohexyl chloride

: 1-chloro-4-(2-cyclohexylethynyl)benzene

Conditions

Conditions	Yield
With copper(l) iodide; C21H23ClNiP2S; caesium carbonate; sodium iodide In dimethyl sulfoxide at 50℃; for 12h; Sonogashira Cross-Coupling; Schlenk technique; Inert atmosphere;	94%

: 14159-55-8
2-cyclohex-1-enyl-pyridine

: 542-18-7
cyclohexyl chloride

: 2-([1,1'-bi(cyclohexan)]-1-en-2-yl)pyridine

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; neopentylmagnesium bromide; cobalt(II) bromide; 1,3-diisopropyl-1H-benzo[d]imidazol-3-ium bromide In tetrahydrofuran at 0 - 20℃; for 6h; Catalytic behavior; Reagent/catalyst; Temperature; Schlenk technique;	92%

: 542-18-7
cyclohexyl chloride

: 10354-51-5
N-butyl-pyridine-2-carboxylic acid amide

: N-n-butyl-3-cyclohexylpicolinamide

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; ethylmagnesium bromide; manganese(ll) chloride In tetrahydrofuran at 60℃; for 14h; Schlenk technique; Inert atmosphere; chemoselective reaction;	92%

: 542-18-7
cyclohexyl chloride

: 886-06-6
1-phenyl-3-piperidino-propan-1-one; hydrochloride

: 52-49-3
trihexylphenidyl hydrochloride

Conditions

Conditions	Yield
Stage #1: cyclohexyl chloride With iodine; magnesium In 1,2-dimethoxyethane; tert-butyl methyl ether at 45 - 55℃; for 2h; Sealed tube; Inert atmosphere; Large scale; Stage #2: 1-phenyl-3-piperidino-propan-1-one; hydrochloride In 1,2-dimethoxyethane; tert-butyl methyl ether at 5 - 10℃; for 2h; Solvent; Sealed tube; Inert atmosphere; Large scale;	90.5%
Stage #1: cyclohexyl chloride With magnesium In tetrahydrofuran; ethyl bromide at 45 - 65℃; for 3h; Stage #2: 1-phenyl-3-piperidino-propan-1-one; hydrochloride In tetrahydrofuran; ethyl bromide at 65℃; for 4h; Stage #3: With hydrogenchloride In tetrahydrofuran; ethyl bromide; water at 65℃; for 0.8h; Temperature;	70.3%

: 542-18-7
cyclohexyl chloride

: 626-62-0
1-iodocyclohexane

Conditions

Conditions	Yield
With hydrogen iodide; cetyltributylphosphonium bromide at 105℃; for 7h;	90%
With hydrogen iodide at 105℃; for 2.5h;	85%
With hydrogen iodide

: 542-18-7
cyclohexyl chloride

: 111757-80-3
(-)-(2S)-trifluoromethanesulfonyloxy-propionic acid tert-butyl ester

: 1059044-01-7
(+)-(2S)-cyclohexyl-propionic acid tert-butyl ester

Conditions

Conditions	Yield
Stage #1: cyclohexyl chloride With magnesium In tetrahydrofuran Inert atmosphere; Stage #2: (-)-(2S)-trifluoromethanesulfonyloxy-propionic acid tert-butyl ester With zinc(II) chloride In tetrahydrofuran at 0℃; for 3h; Inert atmosphere; optical yield given as %ee; enantiospecific reaction;	90%

: 542-18-7
cyclohexyl chloride

: 827-52-1
1-phenyl-1-cyclohexane

: 7325-14-6
1,3,5-tricyclohexylbenzene

Conditions

Conditions	Yield
With aluminum (III) chloride at 0 - 20℃; for 4h; Friedel-Crafts Alkylation;	90%
With aluminum (III) chloride at 0 - 20℃; for 5h;	90%

: 542-18-7
cyclohexyl chloride

: 4294-57-9
para-methylphenylmagnesium bromide

: 4501-36-4
1-cyclohexyl-4-methylbenzene

Conditions

Conditions	Yield
Stage #1: cyclohexyl chloride With [1,3-bis(3,5-di-tert-butyl-2-hydroxybenzyl)benzimidazolium][FeCl4] In diethyl ether at 0℃; for 0.0333333h; Schlenk technique; Inert atmosphere; Stage #2: para-methylphenylmagnesium bromide In diethyl ether at 0 - 30℃; for 2h; Temperature; Reagent/catalyst; Schlenk technique; Inert atmosphere;	89%
With C33H49N2O2(1+)*Cl4Fe(1-) In diethyl ether Reagent/catalyst; Grignard Reaction;	77%
With butylmethylimidazolium tetrachloroferrate In diethyl ether at 0 - 20℃;	75%

: 136918-14-4
phthalimide

: 542-18-7
cyclohexyl chloride

: 2133-65-5
N-cyclohexylphthalimide

Conditions

Conditions	Yield
With potassium fluoride on basic alumina In 2-methyltetrahydrofuran at 90℃; for 12h; Inert atmosphere; chemoselective reaction;	89%

: 124-38-9
carbon dioxide

: 542-18-7
cyclohexyl chloride

: 62-53-3
aniline

: 3770-95-4
O-cyclohexyl N-phenylcarbamate

Conditions

Conditions	Yield
With choline chloride * 2ZnCl2 at 20℃; under 760.051 Torr; for 2h; Green chemistry;	89%

...Expand

: 542-18-7
cyclohexyl chloride

: 108-94-1
cyclohexanone

Conditions

Conditions	Yield
With oxygen; kieselguhr; copper(l) chloride In hexane for 3h; Oxidation; Heating;	88%
Stage #1: cyclohexyl chloride With sodium hydroxide In water at 45 - 50℃; for 2.5h; Stage #2: With quinolinium chlorochromate(VI) In water for 18h;	37%
With pumice stone; vanadia at 350℃; beim Leiten im Gemisch mit Luft und Wasserdampf;

: 542-18-7
cyclohexyl chloride

: (2SP,4R,5S)-(-)-3,4-dimethyl-2,5-diphenyl-1,3,2-oxazaphospholidine borane

: (Sp)-(-)-N-methyl-N-[(1R,2S)-(2-hydroxy-1-methyl-2-phenyl)ethyl]aminocyclohexylphenylphosphine borane

Conditions

Conditions	Yield
Stage #1: cyclohexyl chloride With naphthalene; lithium In tetrahydrofuran at -78℃; for 3h; Stage #2: (2SP,4R,5S)-(-)-3,4-dimethyl-2,5-diphenyl-1,3,2-oxazaphospholidine borane In tetrahydrofuran at -78℃; Further stages.;	88%
Stage #1: cyclohexyl chloride With lithium In Petroleum ether for 5h; Heating; Stage #2: (2SP,4R,5S)-(-)-3,4-dimethyl-2,5-diphenyl-1,3,2-oxazaphospholidine borane In tetrahydrofuran; Petroleum ether at -78 - 0℃;	87%

Chlorocyclohexane Chemical Properties

Molecule structure of Chlorocyclohexane (CAS NO.542-18-7):

IUPAC Name: Chlorocyclohexane
Molecular Formula: C₆H₁₁Cl
Molecular Weight: 118.62 g/mol
Density: 1 g/mL at 25 °C(lit.)
Melting Point: -44 °C
Boiling Point: 142 °C at 760 mmHg
Flash Point: 28.9 °C
Storage Temp.: Flammables area
Water Solubility: 0.02 g/L (20 °C)
Index of Refraction: 1.451
Molar Refractivity: 32.58 cm³
Molar Volume: 120.9 cm³
Surface Tension: 27.7 dyne/cm
XLogP3: 3
Exact Mass: 118.054928
MonoIsotopic Mass: 118.054928
Canonical SMILES: C1CCC(CC1)Cl
InChI: InChI=1S/C6H11Cl/c7-6-4-2-1-3-5-6/h6H,1-5H2
InChIKey: UNFUYWDGSFDHCW-UHFFFAOYSA-N
EINECS: 208-806-6
Product Categories: CHLORO ALKANE COMPOUNDS

Chlorocyclohexane Uses

Chlorocyclohexane (CAS NO.542-18-7) is used as pharmaceutical intermediates. It is also used in organic synthesis.

Chlorocyclohexane Toxicity Data With Reference

1.		ihl-rat LCLo:31 g/m³		GTPZAB Gigiena Truda i Professionalnye Zabolevaniia. Labor Hygiene and Occupational Diseases. 10 (1)(1966),49.
2.		ihl-mus LC50:31 g/m³/2H		85GMAT Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure Izmerov, N.F., et al.,Moscow, USSR.: Centre of International Projects, GKNT,1982,36.

Chlorocyclohexane Consensus Reports

Reported in EPA TSCA Inventory.

Chlorocyclohexane Safety Profile

Hazard Codes: Irritant Xi, Harmful Xn
Risk Statements: 10-36/37/38-20
R10:Flammable.
R36/37/38:Irritating to eyes, respiratory system and skin.
R20:Harmful by inhalation.
Safety Statements: 26-36-37/39-16
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37/39:Wear suitable gloves and eye/face protection.
S16:Keep away from sources of ignition.
RIDADR: UN 1993 3/PG 3
WGK Germany: 1
RTECS: GU8685000
HazardClass: 3
PackingGroup: III
HS Code: 29035990
Slightly toxic by inhalation. When heated to decomposition it emits toxic vapors of Cl⁻.

Chlorocyclohexane Specification

Chlorocyclohexane (CAS NO.542-18-7) is also named as 4-05-00-00048 (Beilstein Handbook Reference) ; AI3-23841 ; BRN 1900796 ; Cyclohexyl chloride ; HSDB 2801 ; Monochlorocyclohexane ; NSC 8434 ; Cyclohexane, chloro- . Chlorocyclohexane (CAS NO.542-18-7) is clear liquid.

Product Name

Chlorocyclohexane

Synthetic route

Chlorocyclohexane Chemical Properties

Chlorocyclohexane Uses

Chlorocyclohexane Toxicity Data With Reference

Chlorocyclohexane Consensus Reports

Chlorocyclohexane Safety Profile

Chlorocyclohexane Specification

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