Cyclopentanone supplier | CasNO.120-92-3

Name
Cyclopentanone
EINECS 204-435-9
CAS No. 120-92-3
Article Data679
CAS DataBase
Density 0.987 g/cm³
Solubility practically insoluble in water
Melting Point -51 °C
Formula C₅H₈O
Boiling Point 130.457 °C at 760 mmHg
Molecular Weight 84.1179
Flash Point 30.556 °C
Transport Information UN 2245 3/PG 3
Appearance colourless liquid
Safety 23
Risk Codes 10-36/38
Molecular Structure
Hazard Symbols Xi
Synonyms Adipicketone;Adipin keton;Dumasin;Ketocyclopentane;Ketopentamethylene;NSC 4122;
PSA 17.07000
LogP 1.12950

Synthetic route

: 96-41-3
Cyclopentanol

: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
With water; nickel dibromide; dibenzoyl peroxide In N,N-dimethyl acetamide at 60℃; for 3h;	100%
With Cp*Ir(6,6'-dionato-2,2'-bipyridine)(H2O) In hexane for 20h; Solvent; Reflux;	100%
With allyl methyl carbonate; dihydridotetrakis(triphenylphosphine)ruthenium In toluene at 100℃; for 13h;	99%

: 142-29-0
cyclopentene

: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
With oxygen; palladium(II) sulfate; PdSO4-H3PMo6W6O40 In cyclohexane; water at 30℃; for 6h;	100%
With oxygen; H3PMo6W6O40 In cyclohexane; water at 29.9℃; under 760 Torr; for 6h;	100%
With palladium(II) sulfate; oxygen; H3PMo6W6O40 In cyclohexane; water at 29.9℃; under 760 Torr; for 6h; Product distribution; Rate constant; other time, other Pd(II) salt, other concentration of catalyst;	100%

: 930-30-3
cyclopent-2-enone

: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
With limonene.; palladium on activated charcoal for 0.5h; Heating;	100%
With hydrogen; SC-1 Ni2B In methanol at 25℃; under 760 Torr; for 24h;	100%
With diphenylsilane; zinc(II) chloride; tetrakis(triphenylphosphine) palladium(0) In chloroform for 0.5h; Ambient temperature;	99%

: 1192-28-5
Cyclopentanone oxime

: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
With bis(1-CH2Ph-3,5,7-3N-1-N(1+)tricyclo[3.3.1.13,7]decaneS2O8 In acetonitrile for 0.0583333h; Oxidation; Heating;	100%
With potassium permanganate In water; acetonitrile at 25℃; for 1h;	96%
With dihydrogen peroxide; tripropylammonium fluorochromate (VI) In acetone at 0 - 10℃; for 2.5h;	96%

: Sodium; 6-cyclopentylideneamino-hexanoate

: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
With hydrogenchloride for 0.0416667h; Product distribution; Ambient temperature; pH = 4-6, regeneration of aldehyde;	100%

: 137-43-9
Cyclopentyl bromide

: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
With oxygen; kieselguhr; copper(l) chloride In hexane for 2.5h; Oxidation; Heating;	99%

: 85895-34-7
1,1-Bis(phenylthio)cyclopentane

: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In acetonitrile at 20 - 25℃; for 2h; Irradiation;	98%

: 98-01-1
furfural

: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
With hydrogen In water at 160℃; under 30003 Torr; for 7h; Automated synthesizer;	98%
With hydrogen In water at 160℃; under 30003 Torr; for 2.5h; Reagent/catalyst; Temperature; Pressure; Autoclave;	96%
With hydrogen In water at 150℃; under 30003 Torr; for 6h; Reagent/catalyst; Autoclave;	95%

: 287-92-3
Cyclopentane

: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
With hydrogenchloride; FeH6Mo6O24(3-)3H3N3H(1+)*7H2O; tetrabutylammomium bromide; dihydrogen peroxide In 1,4-dioxane; water at 85℃; for 24h;	96%
With [Fe4III(μ-O)2(μ-acetate)6(2,2'-bipyridine)2(H2O)2](NO3-)(OH-); dihydrogen peroxide; acetic acid In water; acetonitrile at 32℃; for 3h; Catalytic behavior;	60%
With dihydrogen peroxide; vanadium phosphorus oxide In acetonitrile at 50℃; for 20h;	48%

: 2562-38-1
nitrocyclopentane

: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
With sodium perborate at 70℃; for 3h; Ionic liquid;	95%
With bis-trimethylsilanyl peroxide; sodium hydride In tetrahydrofuran at 20℃; for 24h; Hydrolysis;	65%

: 78795-44-5
1-Methanesulfonyl-1-methylsulfanyl-cyclopentane

: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
With hydrogenchloride In methanol for 3h; Heating;	94%

: 176-38-5
1-oxa-4-thia-spiro[4.4]nonane

: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
With Glyoxilic acid; Amberlyst 15 for 0.05h; microwave irradiation;	94%
With potassium superoxide; tetraethylammonium bromide In N,N-dimethyl-formamide at 20℃; for 3h;	88%

: 124-04-9
Adipic acid

: 1191-25-9
6-Hydroxyhexanoic acid

A: 502-44-3
hexahydro-2H-oxepin-2-one

B: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
at 280 - 300℃; Product distribution / selectivity;	A 7% B 94%
sodium phosphate at 290℃; Product distribution / selectivity;	A 0.3% B 77%
tin(IV) oxide at 270℃; Product distribution / selectivity;	A 1% B 73%
sodium hydroxide at 270 - 290℃; Product distribution / selectivity;	A 25% B 58%
sodium borate at 290℃; Product distribution / selectivity;	A 0.3% B 39%

...Expand

: 627-93-0
hexanedioic acid dimethyl ester

: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
Al2O3#dotK2O In water at 360℃; under 0.750075 Torr; for 500h;	93%

: 96-41-3
Cyclopentanol

: 64-19-7
acetic acid

A: 933-05-1
cyclopentyl acetate

B: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
With dihydrogen peroxide; methyltrioxorhenium(VII); sodium bromide for 10h; Ambient temperature;	A 8% B 92%

...Expand

: menthyl alcohol

: 933-06-2
1-acetoxycyclopentene

: acetic acid mentyl ester

B: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
With tetrabutylammonium tricarbonylnitrosylferrate In hexane at 20 - 80℃; Molecular sieve; Inert atmosphere;	A 92% B n/a

...Expand

: 877-46-3
4-(1-cyclopenten-1-yl)phenol

A: 120-92-3
cyclopentanone

B: 123-31-9
hydroquinone

Conditions

Conditions	Yield
With hydrogenchloride; dihydrogen peroxide In acetonitrile at 50℃; for 3h; the excess of H2O2 was removed by catalytic hydrogenation using 10percent Pd-C;	A n/a B 91.6%

: 19980-43-9
1-(trimethylsilyloxy)cyclopentene

A: 930-30-3
cyclopent-2-enone

B: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
With oxygen; palladium matal-containing silica-supported catalyst In various solvent(s) at 59.9℃; for 24h; Product distribution; Mechanism; Pd(0) supported on various zeolites , influence of calcination and reaction temperature and of the solvent;	A 90.1% B n/a
With oxygen; silica gel; palladium In various solvent(s) at 59.9℃; for 24h; Product distribution; solvent;	A 90.1% B 0.8%
With oxygen; silica gel; palladium In various solvent(s) at 59.9℃; for 24h; Yields of byproduct given;	A 90.1% B n/a
With oxygen; silica gel; palladium In various solvent(s) at 59.9℃; for 24h;	A 90.1% B 0.8%

: 176-32-9
1,4-dioxaspiro[4.4]nonane

: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
With formaldehyd; silica gel; iron(III) chloride at 20℃; for 0.0833333h;	90%
With chloral hydrate In hexane at 25℃; for 0.5h; Solvent; Temperature; Inert atmosphere;	83%
With boron trifluoride diethyl etherate; sodium iodide In acetonitrile for 2h; Heating;	82%
With water; β‐cyclodextrin at 20℃; for 16h;	98 % Chromat.

: 14090-60-9
2-cyclopentylidene-1,1-dimethylhydrazine

: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
With cerium(III) chloride; silica gel for 0.0666667h; Microwave irradiation;	90%
With sodium perborate; sodium hydroxide; potassium dihydrogenphosphate; water In tert-butyl alcohol at 60℃; for 24h;	70%
With ferric nitrate In dichloromethane 30 min., r.t., then reflux;	69%
With silica gel In tetrahydrofuran; water at 25℃; for 10h;	20%

: 1072-59-9
1-methoxycyclopentene

: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
With silica gel; iron(III) chloride at 20℃; for 0.333333h;	90%
With sulfuric acid In water at 25℃; Rate constant;

: 1132-58-7
cyclopentanone phenylhydrazone

: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
With zirconium hydrogen sulfate; silica gel In hexane for 1.5h; Heating;	90%

: bis(η5-cyclopentadienyl)molybdenacyclopentane

A: cyclopentadienylmolybdenum tricarbonyl dimer

B: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
With CO In toluene toluene soln. of Mo complex placed in autoclave under 50 atm CO pressure, stirred at 90°C for 12 h; distn., trapping at -78°C;	A 83% B 90%

: (C4H9)3SnOC5H8Br

: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
decompn. at 150°C for 0.5 h;	88%
decompn. at 150°C for 0.5 h;	88%

: 6651-36-1
1-(Trimethylsilyloxy)cyclohexene

A: 930-68-7
cyclohexenone

B: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
With oxygen; silica gel; palladium In various solvent(s) at 59.9℃; for 24h;	A 87.4% B 0.8%

: 7148-07-4
1-pyrrolidinocyclopent-1-ene

: 719-98-2
2-((trifluoromethyl)thio)isoindoline-1,3-dione

A: 120-92-3
cyclopentanone

B: 2-((trifluoromethyl)thio)cyclopentanone

Conditions

Conditions	Yield
In acetonitrile at 25℃; for 48h; Hydrolysis; trifluoromethylthiolation;	A 12.9% B 87.1%

...Expand

: 142-29-0
cyclopentene

: 10230-26-9
trans-1,2-dibromocyclopentane

B: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
With water; oxygen; lithium bromide; copper(ll) bromide In tetrahydrofuran at 25℃; under 760.051 Torr;	A 87% B n/a

: 274-09-9
Methylenedioxybenzene

A: 120-80-9
benzene-1,2-diol

B: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
With iodo trichloro silane for 1h; Ambient temperature;	A 86% B 39%

: 124-04-9
Adipic acid

: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
With pyrographite at 450℃; for 0.5h;	85%
With calcium hydroxide at 350℃; Product distribution; Further Variations:; Reagents;	84.2%
at 290℃;

: 1003-03-8
Cyclopentamine

: 120-92-3
cyclopentanone

Conditions

Conditions	Yield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene In dichloromethane at 0 - 20℃; for 0.333333h; Inert atmosphere; Green chemistry;	85%
With oxygen; potassium iodide; sodium nitrite In water; acetonitrile for 8h; Reflux;	75%
With potassium hydroxide In ethyl acetate at -78℃; Product distribution;	18%

: 551-93-9
2-aminoacetophenone

: 120-92-3
cyclopentanone

: 6829-07-8
9-methyl-2,3-dihydro-1H-cyclopenta[b]quinoline

Conditions

Conditions	Yield
With 3-methyl-1-sulfoimidazolium trichloroacetate; trichloroacetic acid In neat (no solvent) at 100℃; Friedlaender Quinoline Synthesis;	100%
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In ethyl acetate; N,N-dimethyl-formamide at 90℃; Friedlaender reaction;	98%
With ammonium cerium (IV) nitrate In ethanol for 16h; Friedlaender synthesis; Reflux;	97%

: 100-52-7
benzaldehyde

: 120-92-3
cyclopentanone

: 895-80-7
2,5-dibenzylidenecyclopentanone

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 20℃; Aldol Condensation;	100%
With molybdenum(V) chloride In neat (no solvent) for 0.0416667h; Claisen-Schmidt Condensation; Microwave irradiation; Green chemistry;	99%
With potassium hydroxide In ethanol at 40℃; for 0.00138889h;	98%

: 123-11-5
4-methoxy-benzaldehyde

: 120-92-3
cyclopentanone

: 5447-53-0, 106115-46-2
(2E,5E)-2,5-bis(4-methoxybenzylidene)cyclopentanone

Conditions

Conditions	Yield
With lithium perchlorate; triethylamine at 20℃; for 0.0166667h;	100%
With trichloro(trifluoromethanesulfonato)titanium(IV) at 20℃; for 2h; aldol condensation;	97%
With animal bone meal catalyst modified with Na In water for 0.25h; Reflux;	97%

: 120-92-3
cyclopentanone

: 105-56-6
ethyl 2-cyanoacetate

: 5407-83-0
ethyl 2-cyano-2-cyclopentylideneacetate

Conditions

Conditions	Yield
piperidine at 23℃; under 750.06 Torr; for 2h; Knoevenagel condensation;	100%
With morpholine; bis(acetylacetonate)oxovanadium at 40℃; for 1h; Reagent/catalyst; Temperature; Time; Knoevenagel Condensation;	99%
With ammonium acetate; acetic acid In toluene Knoevenagel Condensation; Reflux;	93%

: 120-92-3
cyclopentanone

: 694-28-0
2-chlorocyclopentanone

Conditions

Conditions	Yield
With iodine; mercury dichloride In dichloromethane for 1h; Ambient temperature;	100%
With N-chloro-succinimide In various solvent(s) at 20℃; for 0.5h;	91%
With N-chloro-succinimide In dimethyl sulfoxide at 20℃; for 0.25h;	87%

: 120-92-3
cyclopentanone

: 1192-28-5
Cyclopentanone oxime

Conditions

Conditions	Yield
With N,O-bis(trimethylsilyl)hydroxylamine; potassium hydride In tetrahydrofuran for 1.5h; Ambient temperature; - 78 deg C to room temp.;	100%
With sodium hydroxide; hydroxylamine hydrochloride at 20℃; for 0.5h; grinding;	100%
With hydroxylamine hydrochloride; sodium acetate In methanol Heating;	100%

: 120-92-3
cyclopentanone

: 96-41-3
Cyclopentanol

Conditions

Conditions	Yield
With zirconium dioxide hydrate; isopropyl alcohol at 130℃; for 0.666667h; Meerwein-Ponndorf-Verley Reduction;	100%
Stage #1: cyclopentanone With tetrabutylammonium tricarbonylnitrosylferrate; tricyclohexylphosphine In 1,4-dioxane at 50℃; Inert atmosphere; Stage #2: With water; sodium hydroxide In 1,4-dioxane; methanol at 20℃; for 1.5h; Inert atmosphere; chemoselective reaction;	99%
With C15H18BF3; hydrogen; tert-butylimino-tri(pyrrolidino)phosphorane In tetrahydrofuran at 75℃; under 75007.5 Torr; for 20h; Glovebox;	99%

: 75-77-4
chloro-trimethyl-silane

: 120-92-3
cyclopentanone

: 19980-43-9
1-(trimethylsilyloxy)cyclopentene

Conditions

Conditions	Yield
With triethylamine; sodium iodide In acetonitrile at 23℃; for 1.5h; Inert atmosphere;	100%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 40℃; for 0.5h;	98%
With magnesium In N,N-dimethyl-formamide at 15 - 25℃;	94%

: 34164-50-6
4-penten-1-ylmagnesium bromide

: 120-92-3
cyclopentanone

: 16133-77-0
1-(pent-4'-enyl)cyclopentan-1-ol

Conditions

Conditions	Yield
	100%
at 0℃;	90%
In diethyl ether for 2h; Ambient temperature;	72%

: 75-52-5
nitromethane

: 120-92-3
cyclopentanone

: 100-53-8
phenylmethanethiol

: 335458-23-6
1-benzylthio-1-nitromethylcyclopentane

Conditions

Conditions	Yield
With piperidine In benzene	100%
With piperidine In acetonitrile for 4h; Heating;	94%
With piperidine In benzene Heating;

...Expand

: 613-94-5
benzoic acid hydrazide

: 120-92-3
cyclopentanone

: 24214-78-6
N'-cyclopentylidene benzohydrazide

Conditions

Conditions	Yield
at 143℃; under 2100.21 Torr; for 0.05h; Microwave irradiation; neat (no solvent);	100%
for 0.05h; Microwave irradiation;	100%
at 20℃; for 0.05h; Microwave irradiation;	100%

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 120-92-3
cyclopentanone

: 106115-49-5
2,5-Bis<(3,4-dimethoxyphenyl)methylen>cyclopentanon

Conditions

Conditions	Yield
With lithium perchlorate; triethylamine at 20℃; for 96h;	100%
With hydrogenchloride; acetic acid at 25 - 30℃; for 2h;	85%
With hydrogenchloride In acetic acid at 25 - 30℃; for 2h;	85%

: 106-95-6
allyl bromide

: 120-92-3
cyclopentanone

: 36399-21-0
1-allylcyclopentan-1-ol

Conditions

Conditions	Yield
With ammonium acetate; zinc In tetrahydrofuran at 0℃; for 0.166667h; Inert atmosphere;	100%
With zinc; bis(cyclopentadienyl)titanium dichloride In tetrahydrofuran for 0.0833333h; Ambient temperature;	98%
With ammonium chloride; zinc In tetrahydrofuran; water at 20℃; for 10h;	90%

: 67-56-1
methanol

: 120-92-3
cyclopentanone

: 931-94-2
1,1-dimethoxycyclopentane

Conditions

Conditions	Yield
With trimethyl orthoformate at 40℃; under 6000480 Torr; for 8h;	100%
Irradiation;	25%
Ce(3+)-mont at 25℃; for 0.5h; Yield given;

: 870-46-2
t-butoxycarbonylhydrazine

: 120-92-3
cyclopentanone

: 79201-39-1
tert-butyl 2-cyclopentylidenehydrazine carboxylate

Conditions

Conditions	Yield
In methanol at 20℃; for 2h;	100%
In methanol at 20℃; for 3h; Inert atmosphere;	98%
In hexane for 0.333333h; Heating;	96%

: 90-11-9
1-Bromonaphthalene

: 120-92-3
cyclopentanone

: 74709-98-1
1-Naphthylcyclopentanol

Conditions

Conditions	Yield
With iodine; magnesium In diethyl ether for 3h; Grignard reaction; Heating;	100%
With iodine; magnesium 1.) ether, reflux, 2.) ether, benzene, RT, 2 h; Yield given. Multistep reaction;
Stage #1: 1-Bromonaphthalene With magnesium In diethyl ether Stage #2: cyclopentanone In diethyl ether for 3h; Grignard reaction;
Stage #1: 1-Bromonaphthalene With magnesium In diethyl ether for 0.5h; Reflux; Stage #2: cyclopentanone In diethyl ether at 0℃; for 1h;

: 16182-15-3
2,4,6-trimethylbenzenesulfonohydrazide

: 120-92-3
cyclopentanone

: 83477-71-8
N'-cyclopentylidene-2,4,6-trimethylbenzenesulfonohydrazide

Conditions

Conditions	Yield
In methanol at 20℃;	100%
In methanol 1.) 50 deg, 2.) room temperature;	88%

: 69739-34-0
t-butyldimethylsiyl triflate

: 120-92-3
cyclopentanone

: 68081-15-2
1-tert-butyldimethylsilyloxycyclopentene

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 0.0833333h;	100%
With 2,6-dimethylpyridine In tetrahydrofuran at 0℃; for 1h;	71%
With triethylamine In dichloromethane at 0℃;

: 78396-88-0
ethyl hydrogen (5,6-dihydro-p-dioxin-2-yl)ethylphosphonite

: 120-92-3
cyclopentanone

: ethyl (5,6-dihydro-p-dioxin-2-yl)(1-hydroxycyclopentyl)phosphinate

Conditions

Conditions	Yield
for 600h; Ambient temperature;	100%

: 120-92-3
cyclopentanone

: 95-54-5
1,2-diamino-benzene

: 41526-78-7
2,3-cyclopentano-3,4-dihydro-5H-4-spirocyclopentano-1,5-benzodiazepine

Conditions

Conditions	Yield
With mesoporous aluminosilicate MCM-41(14) at 100℃; for 1h;	100%
With ytterbium(III) triflate at 20℃; for 4h;	99%
With octadecafluorodecahydronaphthalene (cis+trans) at 60℃; for 2h;	99%

: 120-92-3
cyclopentanone

: 1576-35-8
toluene-4-sulfonic acid hydrazide

: 17529-98-5
cyclopentanone p-tolylsulfonylhydrazone

Conditions

Conditions	Yield
In ethanol at 100℃; for 1h;	100%
In ethanol at 100℃; for 1.66667h; Inert atmosphere;	100%
In methanol at 20℃; Inert atmosphere;	99.5%

: 120-92-3
cyclopentanone

: 4403-69-4
2-amino-1-benzylamine

: 84571-63-1
3',4'-dihydro-1'H-spiro[cyclopentane-1,2'-quinazoline]

Conditions

Conditions	Yield
In chloroform at 60℃; for 24h;	100%
With acetic acid In ethanol for 3h; Heating;	82%

: 120-92-3
cyclopentanone

: 352-13-6
4-flourophenylmagnesium bromide

: 827-57-6
1-cyclopent-1-enyl 4-fluorobenzene

Conditions

Conditions	Yield
Stage #1: cyclopentanone; 4-flourophenylmagnesium bromide In tetrahydrofuran at 0℃; Reflux; Stage #2: With hydrogenchloride In tetrahydrofuran; water	100%
In tetrahydrofuran; diethyl ether at 0℃; for 2h; Reflux;	100%
Stage #1: cyclopentanone; 4-flourophenylmagnesium bromide In tetrahydrofuran at 0℃; for 2h; Reflux; Stage #2: With hydrogenchloride; water In tetrahydrofuran Cooling with ice;	100%
In diethyl ether Grignard reaction; Reflux;	61%
(i), (ii) KHSO4; Multistep reaction;

: 98-01-1
furfural

: 120-92-3
cyclopentanone

: α,α'-bis(2-furylmethylidene)cyclopentanone

Conditions

Conditions	Yield
With sodium hydroxide In ethanol for 0.0166667h; microwave irradiation;	100%
With aluminum oxide; potassium fluoride In methanol at 35 - 40℃; for 0.5h; Claisen-Schmidt condensation; ultrasound irradiation;	96%
With sodium-modified hydroxyapatite In water for 0.5h; Aldol condensation; Reflux;	96%

: 75-52-5
nitromethane

: 108-98-5
thiophenol

: 120-92-3
cyclopentanone

: 109585-27-5
1-nitromethyl-1-phenylthiocyclopentane

Conditions

Conditions	Yield
With piperidine In benzene for 61h; Heating;	100%

...Expand

Cyclopentanone Specification

The Cyclopentanone, with the CAS registry number 120-92-3 and EINECS registry number 204-435-9, is a clear colorless liquid with a petroleum-like odor. It belongs to the following product categories: Pharmaceutical Intermediates; Organics; Alpha Sort; C; Volatiles/ Semivolatiles; C3 to C6; Carbonyl Compounds; Ketones; Alphabetical Listings; C-D; Flavors and Fragrances. And the molecular formula of the chemical is C₅H₈O. What's more, it is commonly used as a thinner for various epoxies used in MEMS fabrication, such as SU-8.

The physical properties of Cyclopentanone are as followings: (1)ACD/LogP: 0.29; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.293; (4)ACD/LogD (pH 7.4): 0.293; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 34.405; (8)ACD/KOC (pH 7.4): 34.405; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 17.07 Å²; (13)Index of Refraction: 1.457; (14)Molar Refractivity: 23.189 cm³; (15)Molar Volume: 85.214 cm³; (16)Polarizability: 9.193×10^-24cm³; (17)Surface Tension: 34.01 dyne/cm; (18)Density: 0.987 g/cm³; (19)Flash Point: 30.556 °C; (20)Enthalpy of Vaporization: 36.35 kJ/mol; (21)Boiling Point: 130.457 °C at 760 mmHg; (22)Vapour Pressure: 9.702 mmHg at 25°C.

Preparation of Cyclopentanone: This chemical can be prepared by adipate in the presence of baryta with heating.

Uses of Cyclopentanone: It can react with pyrrolidine to produce 1-cyclopent-1-enyl-pyrrolidine. This reaction will need reagent methyl iodide and bis(trimethylsilyl)acetamide, and the menstruum petroleum ether. The reaction time is 1.5 hours with temperature of 40-50°C, and the yield is about 82%.

You should be cautious while dealing with this chemical. It is a kind of flammble chemical which irritates to eyes and skin. Therefore, you had better not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer).

You can still convert the following datas into molecular structure:
(1)SMILES: C1CCC(=O)C1
(2)InChI: InChI=1/C5H8O/c6-5-3-1-2-4-5/h1-4H2
(3)InChIKey: BGTOWKSIORTVQH-UHFFFAOYAP

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
frog	LDLo	subcutaneous	3gm/kg (3000mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) SKIN AND APPENDAGES (SKIN): SWEATING: OTHER AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC	Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 50, Pg. 199, 1903.
mammal (species unspecified)	LD50	oral	2gm/kg (2000mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(10), Pg. 25, 1988.
mouse	LD50	intraperitoneal	1950mg/kg (1950mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: COMA	Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. Vol. 254, Pg. 2245, 1962.
mouse	LDLo	subcutaneous	2600mg/kg (2600mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: COMA AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC	Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 50, Pg. 199, 1903.
rat	LC50	inhalation	19500mg/m3 (19500mg/m3)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: DYSPNEA LIVER: OTHER CHANGES	National Technical Information Service. Vol. OTS0572861,

Product Name

Cyclopentanone

Synthetic route

Cyclopentanone Specification

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