(RS)-mandelonitrile
(R)-Mandelic Acid
Conditions | Yield |
---|---|
In aq. phosphate buffer at 40℃; for 0.5h; pH=8; Reagent/catalyst; Time; | 100% |
With Escherichia coli M15/BCJ2315 harboring the nitrilase BCJ2315 from Burkholderia cenocepacia J2315 wet cells In methanol; aq. phosphate buffer for 24h; pH=8; Large scale; enantioselective reaction; | 93% |
With phosphate buffer; nitrilase I In methanol at 37℃; for 3h; pH=8; | 86% |
(R)-Mandelic Acid
Conditions | Yield |
---|---|
With hydrogenchloride In water-d2 at 100℃; for 16h; Inert atmosphere; | 100% |
d'acide 2-fluoro-2-phenyl acetique
A
(R)-Mandelic Acid
B
(R)-α-fluoro-α-phenylacetic acid
Conditions | Yield |
---|---|
With fluoroacetate dehalogenase RPA1163-W185N for 1h; Catalytic behavior; Kinetics; Enzymatic reaction; enantioselective reaction; | A 96.4% B 96.7% |
With fluoroacetate dehalogenase RPA1163 In aq. buffer at 30℃; for 2h; pH=7.5; Kinetics; Catalytic behavior; Resolution of racemate; Microbiological reaction; Enzymatic reaction; enantioselective reaction; | A n/a B n/a |
(R)-1-phenyl-1,2-ethanediol
(R)-Mandelic Acid
Conditions | Yield |
---|---|
With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide In acetone at 0℃; pH=8.3; chemoselective reaction; | 96% |
With recombinant alditol oxidase from Streptomyces coelicolor A3(2); catalase from bovine liver at 25℃; pH=7.5; Kinetics; Reagent/catalyst; Temperature; pH-value; aq. phosphate buffer; Enzymatic reaction; enantioselective reaction; |
(S)-2-hydroxymethyl-N-((R)-2-hydroxy-2-phenyl)-acetyl pyrrolidine
(R)-Mandelic Acid
Conditions | Yield |
---|---|
With sulfuric acid In water at 90℃; for 0.5h; | 95% |
With sulfuric acid at 90℃; for 0.5h; | 93% |
Conditions | Yield |
---|---|
With C48H50N2O2P2Ru*2C18H15P*4Cl(1-)*2Ru(2+); hydrogen; sodium acetate; triphenylphosphine In methanol at 0℃; under 30003 Torr; for 24h; Autoclave; enantioselective reaction; | 94% |
With phosphate buffer; D-glucose; 2-hydroxyethanethiol; sodium chloride; 1,4-dihydronicotinamide adenine dinucleotide; benzoylformate reductase In water; toluene at 30℃; for 48h; Product distribution; Other catalysts: bovine serum albumin, yeast alcohol dehydrogenase, glucose dehydrogenase, formate dehydrogenase; | 93% |
With phosphate buffer; D-glucose; 2-hydroxyethanethiol; sodium chloride; formate dehydrogenase; 1,4-dihydronicotinamide adenine dinucleotide; benzoylformate reductase; bovine serum albumin; yeast alcohol dehydrogenase In ethanol; water; toluene at 30℃; for 48h; | 93% |
(1S,2S)-trans-2-(N-benzyl)amino-1-cyclohexanol (S)-mandelic acid salt
A
(R)-Mandelic Acid
Conditions | Yield |
---|---|
With hydrogenchloride In water; ethyl acetate | A 94% B n/a |
vinyl acetate
MANDELIC ACID
A
(R)-Mandelic Acid
B
(S)-acetylmandelic acid
Conditions | Yield |
---|---|
In acetone; toluene at 37℃; for 24h; Pseudomonas sp. lipase; | A 92% B 84% |
With Burkholderia ambifaria YCJ01 lipase In di-isopropyl ether at 50℃; for 26h; Resolution of racemate; Enzymatic reaction; enantioselective reaction; | A n/a B n/a |
With lipase LC2-8 from P. stutzeri LC2-8 In di-isopropyl ether at 30℃; Solvent; Temperature; Resolution of racemate; Enzymatic reaction; | A n/a B n/a |
A
(SR)-(+/-)-1-phenyl-2-(1-pyrrolidinyl)-1-propanone
B
(R)-Mandelic Acid
Conditions | Yield |
---|---|
With hydrogenchloride; sodium hydroxide In water; ethyl acetate at 0 - 80℃; for 5h; pH=2; | A 89.2% B n/a |
(R)-Mandelic Acid
Conditions | Yield |
---|---|
With potassium phosphate; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; ascorbic acid In water; acetonitrile at 20℃; for 1h; Irradiation; | 89% |
(R)-Mandelonitrile
(R)-Mandelic Acid
Conditions | Yield |
---|---|
With hydrogenchloride for 6h; Heating; | 88% |
With hydrogenchloride 1a) r.t., 18 h, 1b) 60 deg C, 3 h, 1c) reflux, 2 h; | 82% |
With hydrogenchloride; water at 65 - 70℃; for 40h; optical yield given as %ee; enantioselective reaction; | 10.34 g |
(R)-S-ethyl hydroxy-phenyl-thioacetate
(R)-Mandelic Acid
Conditions | Yield |
---|---|
With lithium hydroxide; dihydrogen peroxide In tetrahydrofuran | 86% |
With lithium hydroxide; dihydrogen peroxide In tetrahydrofuran; water at 0℃; for 0.5h; Hydrolysis; | 85% |
(R)-Mandelic Acid
Conditions | Yield |
---|---|
With hydrogenchloride In acetic acid at 120℃; | 81% |
(R)-Mandelic Acid
Conditions | Yield |
---|---|
With hydrogenchloride In water for 2h; Reflux; | 80% |
(R)-methyl mandelate
(R)-Mandelic Acid
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol at 0℃; for 2h; | 74% |
With sodium dihydrogenphosphate; Candida antarctica B lipase immobilized on polyethyleneimine In water at 25℃; pH=7; Kinetics; Further Variations:; Reagents; pH-values; | |
With sodium hydroxide In water at 40℃; for 1h; | 41.4 g |
(1R,4R)-sertraline*(R)-mandelic acid
(R)-Mandelic Acid
Conditions | Yield |
---|---|
Stage #1: (1R,4R)-sertraline*(R)-mandelic acid With sodium hydroxide In water; toluene at 70℃; for 0.5 - 1h; Stage #2: With hydrogenchloride; water pH=< 0.5; | 70% |
MANDELIC ACID
A
(S)-Mandelic acid
B
(R)-Mandelic Acid
Conditions | Yield |
---|---|
Stage #1: MANDELIC ACID With (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R)-2-[(R)-1-benzylamino-1-phenylmethyl]butanoate In dichloromethane; acetone at 25℃; for 12h; Resolution of racemate; Stage #2: With sodium carbonate In diethyl ether Stage #3: With hydrogenchloride In diethyl ether; water optical yield given as %ee; | A 61% B 28% |
Stage #1: MANDELIC ACID With L-alanin In water at 20℃; for 48h; resolution of racemate; Stage #2: With hydrogenchloride In water | |
With (2S,3S)-2,3-dibenzyloxy-1,4-bis(hydroxyamino)butane In ethanol; water Resolution of racemate; |
2-acetoxy-2-phenylacetic acid
A
(R)-Mandelic Acid
B
(S)-acetylmandelic acid
Conditions | Yield |
---|---|
With immobilized lipase B from Candida antarctica; ammonia In di-isopropyl ether at 25℃; for 12h; Solvent; Temperature; Resolution of racemate; Enzymatic reaction; | A 49% B n/a |
(R)-Mandelic Acid
Conditions | Yield |
---|---|
With sodium hydroxide In water | 46% |
MANDELIC ACID
A
(S)-Mandelic acid
B
(2R)-mandelamide
C
(R)-Mandelic Acid
Conditions | Yield |
---|---|
With ammonium bicarbonate In water; dimethyl sulfoxide at 50℃; for 8h; Time; Reagent/catalyst; Temperature; Enzymatic reaction; | A n/a B 46% C n/a |
MANDELIC ACID
(R)-Mandelic Acid
Conditions | Yield |
---|---|
Stage #1: MANDELIC ACID With (1R,2R,4R)-N-benzyl-1,7,7-trimethylbicyclo[2.2.1]heptan-2-amine In acetonitrile at 20℃; Reflux; Inert atmosphere; Resolution of racemate; Stage #2: With hydrogenchloride In water Inert atmosphere; | 37% |
With ethanol; ephedrine | |
With (+)-neoisothujylamine |
MANDELIC ACID
A
(S)-Mandelic acid
B
(R)-Mandelic Acid
C
Benzoylformic acid
D
benzoic acid
Conditions | Yield |
---|---|
With potassium phosphate buffer; Pseudomonas putida ECU1009 at 30℃; for 6h; pH=6.0; | A n/a B n/a C 2% D n/a |
Conditions | Yield |
---|---|
With bacterium ascendens; calcium carbonate | |
With bacterium subtilis; calcium carbonate | |
With bacterium prodigiosum; bacterium proteus; calcium carbonate | |
bei der Einw. von Bact. coli, fluorescens und pyocyaneum; | |
With bacterium lactis aerogenes |
Conditions | Yield |
---|---|
With fermenting yeast | |
With oidium lactis |
(R)-2-bromo-2-phenylacetic acid
(R)-Mandelic Acid
Conditions | Yield |
---|---|
With ammonium hydroxide |
hydroxy-phenyl-acetic acid ethyl ester
(R)-Mandelic Acid
Conditions | Yield |
---|---|
Enzymatische Hydrolyse.Hydrolysis; | |
Multi-step reaction with 3 steps 1: 84 percent / C5H5N 2: 4.85 g / 72 h / 30 °C / microbial hydrolysis 3: 985 mg / 2.4 N HCl / 4 h / Heating View Scheme |
Conditions | Yield |
---|---|
With emulsin; water Verseifung mit Salzsaeure; |
amygdalin
(R)-Mandelic Acid
Conditions | Yield |
---|---|
With hydrogenchloride | |
With sulfuric acid Hydrolysis; |
phenylethane 1,2-diol
A
(S)-Mandelic acid
B
(R)-1-phenyl-1,2-ethanediol
C
(R)-Mandelic Acid
D
Benzoylformic acid
E
benzoic acid
Conditions | Yield |
---|---|
In ethanol; water at 30℃; for 168h; Product distribution; Mechanism; Bacillus subtilis subsp. niger IFO 3108, on nutrient agar plates pH 7.0; other solvents, other microorganisms; stereoselectivity; |
phenylethane 1,2-diol
A
(S)-Mandelic acid
B
(R)-Mandelic Acid
C
Benzoylformic acid
D
benzoic acid
Conditions | Yield |
---|---|
In ethanol; water at 30℃; for 168h; Bacillus subtilis subsp. niger IFO 3108, on nutrient agar plates pH 7.0; Yield given. Further byproducts given. Yields of byproduct given; |
(R)-Mandelic Acid
methyl iodide
methyl (R)-(-)-2-methoxy-2-phenylacetate
Conditions | Yield |
---|---|
With silver(l) oxide for 1h; Heating; | 100% |
Stage #1: (R)-Mandelic Acid With n-butyllithium; dimethyl sulfoxide In hexane for 2h; Stage #2: methyl iodide In hexane; dimethyl sulfoxide | 100% |
Stage #1: (R)-Mandelic Acid With MeSOCH2Li In dimethyl sulfoxide Stage #2: methyl iodide In dimethyl sulfoxide | 99.5% |
Conditions | Yield |
---|---|
In diethyl ether Methylation; | 100% |
90% |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid for 3h; Heating; | 100% |
With toluene-4-sulfonic acid for 3h; Reflux; Inert atmosphere; | 100% |
With thionyl chloride 10 min at -10 deg C and 4 h at r.t.; | 98% |
Conditions | Yield |
---|---|
With potassium hydroxide In diethyl ether; water at 0℃; for 0.25h; | 100% |
Conditions | Yield |
---|---|
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 20℃; for 16h; | 99.8% |
N,N-dimethylaminomethyltriethoxysilane
(R)-Mandelic Acid
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; | 99.1% |
Conditions | Yield |
---|---|
With dihydroxy-methyl-borane; water In o-xylene for 12h; Molecular sieve; Reflux; chemoselective reaction; | 99% |
Conditions | Yield |
---|---|
With (2-(thiophen-2-ylmethyl)phenyl)boronic acid In 1,2-dichloro-ethane at 65℃; for 48h; Inert atmosphere; Molecular sieve; | 99% |
With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide In tetrahydrofuran at 0 - 20℃; for 20.25h; | 57% |
With tris(2,2,2-trifluoroethyl) borate at 125℃; under 760.051 Torr; for 24h; | 24% |
(R)-Mandelic Acid
tetra-n-butylphosphonium hydroxide
Conditions | Yield |
---|---|
In water at 20℃; for 2h; | 99% |
bis(trichloromethyl) carbonate
(R)-Mandelic Acid
(R)-(-)-5-phenyl-1,3-dioxolane-2,4-dione
Conditions | Yield |
---|---|
With triethylamine In acetonitrile at 25℃; for 6h; Temperature; Solvent; | 99% |
With pyrographite In tetrahydrofuran at 20℃; for 20h; |
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; | 98.7% |
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate for 1h; Esterification; Heating; | 98% |
With sulfuric acid for 4h; Heating; | 91% |
With sulfuric acid |
Conditions | Yield |
---|---|
98% | |
With pyridine In dichloromethane 0 deg C, 15 min and 2 h, 20 deg C; Yield given; | |
for 1h; Heating; |
Conditions | Yield |
---|---|
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 1h; Esterification; | 98% |
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane | 98% |
(R)-Mandelic Acid
benzyl-methyl-amine
(R)-N-benzyl-2-hydroxy-N-methyl-2-phenylacetamide
Conditions | Yield |
---|---|
With dihydroxy-methyl-borane; water In toluene for 24h; Molecular sieve; Reflux; | 98% |
Conditions | Yield |
---|---|
With N-iodo-succinimide In dichloromethane at 20 - 22℃; for 0.25h; regioselective reaction; | 98% |
Conditions | Yield |
---|---|
In ethyl acetate at 25 - 50℃; Product distribution / selectivity; | 97% |
(R)-Mandelic Acid
dodecyl-dimethyl-(2-phenoxy-ethyl)-ammonium; chloride
domiphen (R)-(-)-mandelate
Conditions | Yield |
---|---|
With potassium hydroxide In water at 60℃; for 5h; | 97% |
Cyclododecylamine
(R)-Mandelic Acid
(R)-N-cyclododecyl-2-hydroxy-2-phenylacetamide
Conditions | Yield |
---|---|
With dihydroxy-methyl-borane; water; benzoic acid In toluene for 12h; Molecular sieve; Reflux; | 97% |
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 24h; | 97% |
(R)-Mandelic Acid
N,N-bis(trimethylsilyloxy)-1-propen-2-amine
Conditions | Yield |
---|---|
In dichloromethane; N,N-dimethyl-formamide at 20℃; for 2h; regioselective reaction; | A n/a B 97% |
Conditions | Yield |
---|---|
With sodium hydroxide In water Darkness; | 96% |
(R)-Mandelic Acid
pivalaldehyde
(2R,5R)-2-(tert-butyl)-5-phenyl-1,3-dioxolan-4-one
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid In pentane for 6h; Reflux; | 95% |
With trifluorormethanesulfonic acid In pentane for 6h; Heating; | 91% |
With toluene-4-sulfonic acid In pentane for 7h; Heating; | 85% |
1,1-Diphenylmethanol
(R)-Mandelic Acid
benzhydryl (2R)-2-hydroxy-2-phenylacetate
Conditions | Yield |
---|---|
With iron(III)-acetylacetonate In 5,5-dimethyl-1,3-cyclohexadiene for 16h; Inert atmosphere; Reflux; | 95% |
The D-mandelic acid is an organic compound with the formula C8H8O3. The IUPAC name of this chemical is (2R)-2-hydroxy-2-phenylacetic acid. With the CAS registry number 611-71-2, it is also named as 2-hydroxy-2-phenylacetic acid. The product's categories are Fine Chemical & Intermediates; Chiral Compounds; Chiral; Miscellaneous; Analytical Chemistry; Carboxylic Acids (Chiral); Chiral Building Blocks; e.e. / Absolute Configuration Determination (NMR); Enantiomer Excess & Absolute Configuration Determination; for Resolution of Bases; Optical Resolution; Synthetic Organic Chemistry; Chiral Compound. Besides, it is a white to light yellow crystal powder, which should be stored in a closed cool and dry place.
Physical properties about D-mandelic acid are: (1)ACD/LogP: 0.55; (2)ACD/LogD (pH 5.5): -1.98; (3)ACD/LogD (pH 7.4): -3.12; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 1.00; (7)ACD/KOC (pH 7.4): 1.00; (8)#H bond acceptors: 3 ; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 3; (11)Index of Refraction: 1.591; (12)Molar Refractivity: 38.904 cm3; (13)Molar Volume: 115.131 cm3; (14)Polarizability: 15.423 10-24cm3; (15)Surface Tension: 60.4739990234375 dyne/cm; (16)Density: 1.322 g/cm3; (17)Flash Point: 162.649 °C; (18)Enthalpy of Vaporization: 59.501 kJ/mol; (19)Boiling Point: 321.827 °C at 760 mmHg
Preparation of D-mandelic acid: this chemical can be prepared by 2,2-dichloro-1-phenyl-ethanone. This reaction will need reagent NaOH-solution.
Uses of D-mandelic acid: it can be used to produce acetoxy-phenyl-acetic acid bt heating. This reaction time is 1 hour.
When you are using this chemical, please be cautious about it as the following:
It is risk of serious damage to eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable protective clothing, do not breathe dust and avoid contact with skin and eyes.
You can still convert the following datas into molecular structure:
(1)InChI=1S/C8H8O3/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5,7,9H,(H,10,11)/t7-/m1/s1;
(2)InChIKey=IWYDHOAUDWTVEP-SSDOTTSWSA-N;
(3)Smilesc1([C@H](C(O)=O)O)ccccc1
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View