Dimethyl carbonate supplier

Name
Dimethyl carbonate
EINECS 210-478-4
CAS No. 616-38-6
Article Data337
CAS DataBase
Density 1.024 g/cm³
Solubility 139 g/L in water
Melting Point 2-4 °C(lit.)
Formula C₃H₆O₃
Boiling Point 90.5 °C at 760 mmHg
Molecular Weight 90.0788
Flash Point 18.333 °C
Transport Information UN 1161 3/PG 2
Appearance colourless liquid
Safety 9-16
Risk Codes 11
Molecular Structure
Hazard Symbols F
Synonyms Methyl carbonate ((MeO)2CO);Carbonic acid, dimethyl ester;Dimethyl carbonate [UN1161] [Flammable liquid];Carbonic acid,esters,dimethyl ester;Methyl Carbonate;
PSA 35.53000
LogP 0.39920

Synthetic route

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; triethylamine at 90 - 100℃; under 40 - 80 Torr;	100%
With <2>*H2O at 120℃; under 15200 Torr; for 7h;	45.2%
With sodium selenite; oxygen at 100℃; under 37503.8 Torr; for 2h; Reagent/catalyst; Temperature;	32.9%

: 96-49-1
[1,3]-dioxolan-2-one

: 67-56-1
methanol

A: 107-21-1
ethylene glycol

B: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
anion exchanging resin at 80.4 - 98℃; for 6h; Product distribution / selectivity;	A 99% B 99.7%
potassium hydroxide In water at 98℃; under 838.584 Torr; for 500 - 6000h; Product distribution / selectivity; Heating / reflux;	A n/a B 99.88%
potassium hydroxide at 98 - 130℃; under 784.578 - 838.584 Torr; for 500 - 6000h; Product distribution / selectivity; Heating / reflux;	A n/a B 99.99%

...Expand

: 96-49-1
[1,3]-dioxolan-2-one

: 67-56-1
methanol

A: 107-21-1
ethylene glycol

B: 616-38-6
carbonic acid dimethyl ester

C: 111-46-6
diethylene glycol

Conditions

Conditions	Yield
potassium hydroxide at 63.8 - 98℃; for 6.7h; Product distribution / selectivity;	A 99.1% B 99.8% C n/a
sodium hydroxide at 49.8 - 56.2℃; under 342.034 Torr; Product distribution / selectivity; Industry scale;	A 91.3% B 91.3% C n/a
potassium hydroxide at 47 - 56℃; under 228.023 - 342.034 Torr; Product distribution / selectivity; Industry scale;	A 90.5% B 90.5% C n/a
at 55.9 - 56℃; under 342.034 Torr; Product distribution / selectivity; Industry scale;	A 38.9% B 38.9% C n/a

...Expand

: 67-56-1
methanol

: 79-22-1
methyl chloroformate

: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
With 1-methyl-1H-imidazole In Diethyl carbonate at 0 - 20℃; for 1h;	98.2%
at 30℃; Rate constant; Mechanism; var. conc, presence of var. salts (LiCl, (CH3)4NCl, (C2H5)4NBr);
at 30℃; Thermodynamic data; Rate constant; ΔH(excit.), -ΔS(excit.);

: 67-56-1
methanol

: 116-16-5
1,1,1,3,3,3-hexachloro-propan-2-one

: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
Stage #1: methanol With Tetraethylene glycol dimethyl ether; potassium carbonate at 10 - 30℃; Stage #2: 1,1,1,3,3,3-hexachloro-propan-2-one at 30 - 75℃; Reagent/catalyst;	97%

: 67-56-1
methanol

: 124-38-9
carbon dioxide

: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
With 2-Cyanopyridine; cerium(IV) oxide at 119.84℃; under 37503.8 Torr; for 16h; Reagent/catalyst; Pressure; Temperature; Autoclave;	96%
With 2-pyrazine carbonitrile at 20 - 50℃; under 15001.5 - 45004.5 Torr; for 50h; Reagent/catalyst; Temperature; Pressure; Autoclave;	95%
With 2-Cyanopyridine; cerium(IV) oxide at 119.84℃; under 37503.8 Torr; for 12h; Autoclave;	94%

: 96-49-1
[1,3]-dioxolan-2-one

: 67-56-1
methanol

: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
With graphitic carbon nitride at 119.84℃; for 4h; Catalytic behavior; Concentration; Reagent/catalyst; Time;	93%
With 2-hydroxymethyl-1-methyl-3-n-buthylimidazole bromide; potassium carbonate at 60℃; for 1h; Green chemistry;	90%
With mesoporous carbon nitride detemplated by 0.5 M NaOH solution at 160℃; under 4500.45 Torr; for 6h; Catalytic behavior; Knoevenagel Condensation; Autoclave;	90.7%

: 108-32-7
1,2-propylene cyclic carbonate

: 67-56-1
methanol

: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
at 90℃; for 3h; Temperature; Time;	93%
With calcined hollow titanium silicon molecular sieve modified with sodium carbonate and ammonium dihydrogen phosphate In water at 100℃; for 8h; Time; Reagent/catalyst; Temperature; Autoclave;	74%
at 140℃; for 6h;	35%

: 67-56-1
methanol

: 106729-72-0
(2-hydroxyethyl) methyl carbonate

A: 107-21-1
ethylene glycol

B: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
With film supported Penicillium expansum at 60℃; for 48h; Reagent/catalyst; Concentration; Temperature; Time; Enzymatic reaction;	A 93% B 93%

...Expand

: 67-56-1
methanol

: 584-07-6
methyl N-hydroxycarbamate

: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
With lead dioxide In dichloromethane at 40℃; for 0.166667h;	92.1%

: 15411-45-7
Dimethyl peroxydicarbonate

: 931-57-7
1-methoxy-cyclohex-1-ene

A: 616-38-6
carbonic acid dimethyl ester

B: 171512-51-9
1-methoxy-cyclohex-1-en-6-yl methyl carbonate

Conditions

Conditions	Yield
In dichloromethane for 0.5h; Heating;	A n/a B 91%

...Expand

: 67-56-1
methanol

: 57-13-6
urea

: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
With sulfolane; nickel diacetate; triphenylphosphine at 85 - 170℃; for 10h;	89.3%
Stage #1: urea With carbon dioxide; 1-(6',7'-dihydroxy-4'-thioxoheptyl)-3-methylimidazolium trifluoromethanesulfonimide; zinc(II) oxide at 150℃; for 8h; Autoclave; Stage #2: methanol at 150℃; for 2h; Catalytic behavior; Reagent/catalyst; Temperature; Concentration; Autoclave;	87%
catalyst composition: potassium oxide 2 wt percent, zinc oxide 31 wt percent, Al2O3 67 wt percent at 170 - 200℃; under 15001.5 Torr; Product distribution / selectivity;	76.88%

: 124-38-9
carbon dioxide

: 77-76-9
2,2-dimethoxy-propane

A: 67-64-1
acetone

B: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
With dibutyldimethoxytin at 180℃; under 1520000 Torr; for 24h;	A 85% B 88%

...Expand

: 124-38-9
carbon dioxide

: 77-76-9
2,2-dimethoxy-propane

A: 116-11-0
2-Methoxypropene

B: 67-64-1
acetone

C: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
With dibutyldimethoxytin at 180℃; under 1520000 Torr; for 24h; Product distribution; metal-catalyzed reaction of acetals with CO2; effect of catalyst structure; effect of additives; pressure effect; possible mechanism;	A n/a B 85% C 88%

...Expand

: 108-32-7
1,2-propylene cyclic carbonate

A: 57-55-6
propylene glycol

B: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
With potassium carbonate In methanol at 119.84℃; for 2h; Temperature; Concentration; Autoclave; Industrial scale;	A n/a B 88%

: 67-56-1
methanol

: C11H17N2O3S(1+)*C2F6NO4S2(1-)

A: 1337384-29-8
1-(6',7'-dihydroxyl-4'-thiaheptyl)-3-methylimidazolium bis((trifluoromethyl)sulfonyl)imide

B: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
With zinc(II) oxide at 150℃; Concentration; Time; Green chemistry;	A n/a B 87%

...Expand

: 74-87-3
methylene chloride

: 298-14-6
potassium hydrogencarbonate

A: 115-10-6
Dimethyl ether

B: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
tetrahexylammonium chloride In N,N-dimethyl acetamide at 150℃;	A n/a B 86%

...Expand

: 96-49-1
[1,3]-dioxolan-2-one

A: 107-21-1
ethylene glycol

B: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
With potassium carbonate In methanol at 169.84℃; for 1h; Temperature; Reagent/catalyst; Autoclave;	A n/a B 86%
With polystyrene resin bound methylimidazole hydroxyl ionic liquid catalyst In methanol at 80℃; for 8h; Catalytic behavior; Temperature; Ionic liquid;
With 2,6-di(isopropyl)pyridine In methanol at 90℃; under 760.051 Torr; for 10h; Temperature; Reagent/catalyst; Solvent; Inert atmosphere;
With methanol; C5H11N4(1+)*HO(1-) at 20℃; for 12h; Reagent/catalyst; Temperature; Flow reactor;

: 74-87-3
methylene chloride

: 534-17-8
caesium carbonate

: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
In 1-methyl-pyrrolidin-2-one; water at 155 - 160℃; under 11251.1 - 15001.5 Torr; for 12h;	85.3%

: 67-56-1
methanol

: 57-13-6
urea

A: 598-55-0
methyl carbamate

B: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
at 179.84℃; for 10h;	A 84.8% B 6.5%
With zinc/aluminum mixed oxide at 179.84℃; for 10h; Reagent/catalyst; Autoclave;	A 55.1% B 36.5%
calcined La(NO3)3x6H2O at 170℃; under 14821 Torr; for 4h; Product distribution / selectivity; Autoclave; Inert atmosphere;	A 41.2% B 53.4%
With Zn/Ca-catalyst at 179.84℃; for 10h;	A 50.5% B 41.2%
With Ga2O3/CeO2-Al2O3 at 110℃; for 5h;

...Expand

: 96-49-1
[1,3]-dioxolan-2-one

: 67-56-1
methanol

A: 106729-72-0
(2-hydroxyethyl) methyl carbonate

B: 107-21-1
ethylene glycol

C: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
With carbon dioxide at 160℃; under 4500.45 Torr; for 4h; Catalytic behavior; Reagent/catalyst; Autoclave;	A n/a B n/a C 83.3%
at 65.5456 - 162.768℃; under 5171.62 Torr; for 8h; Conversion of starting material;
With 1-octyl-4-aza-1-azoniabicyclo[2.2.2]octane bromide at 70℃; for 4h;	A n/a B 21 %Chromat. C 22 %Chromat.
With potassium hydrogencarbonate at 120℃; under 16274.9 Torr; Temperature; Reagent/catalyst;

...Expand

: 74-87-3
methylene chloride

: 497-19-8
sodium carbonate

: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
In ethanol; water at 115 - 120℃; under 7500.75 - 11251.1 Torr; for 16h;	82.8%

: 124-38-9
carbon dioxide

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

A: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

B: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
at 110℃; under 37503 Torr; for 15h;	A n/a B 82%

...Expand

: 67-56-1
methanol

: 124-38-9
carbon dioxide

: 6257-10-9
N,N'-dicyclohexyl-O-methyl isourea

: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
With sodium methyl carbonate at 64.85℃; under 37503 Torr; for 24h;	80.3%

...Expand

: 108-32-7
1,2-propylene cyclic carbonate

: 67-56-1
methanol

A: 57-55-6
propylene glycol

B: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
With eggshell calcinated at 800 grad C at 25℃; under 760.051 Torr; for 2h;	A 60% B 80%
With superbasic sodium stannate sample(623) at 79.84℃; for 5h;	A n/a B 72.6%
With MCM-41-pr-TMEDA(+)Cl(-) at 120℃; for 4h;	A n/a B 68%

...Expand

: 67-56-1
methanol

: 826-29-9
4-allyloxymethyl-1,3-dioxolan-2-one

A: 123-34-2
3-allyloxy-1,2-propanediol

B: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
With MCM-41-pr-TMEDA(+)Cl(-) at 120℃; for 4h;	A n/a B 79%

...Expand

: 584-07-6
methyl N-hydroxycarbamate

: 67-63-0
isopropyl alcohol

A: 51729-83-0
methyl 1-methylethyl carbonate

B: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
With lead dioxide In dichloromethane at 40℃; for 0.166667h;	A 77.7% B 14.6%

...Expand

: 74-87-3
methylene chloride

: 584-08-7
potassium carbonate

: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
In N,N-dimethyl acetamide; water at 145 - 150℃; for 11h;	74.7%

: 616-38-6
carbonic acid dimethyl ester

: 32315-10-9
bis(trichloromethyl) carbonate

Conditions

Conditions	Yield
With chlorine In tetrachloromethane for 18h; Irradiation;	100%
With chlorine In tetrachloromethane for 28h; Irradiation;	97%
With chlorine for 33h; chlorination;	88%

: 108-94-1
cyclohexanone

: 616-38-6
carbonic acid dimethyl ester

: 41302-34-5
2-(methoxycarbonyl)cyclohexanone

Conditions

Conditions	Yield
Stage #1: carbonic acid dimethyl ester With sodium hydride In toluene; mineral oil for 1h; Reflux; Stage #2: cyclohexanone In toluene; mineral oil for 3h; Reflux;	100%
Stage #1: carbonic acid dimethyl ester With sodium hydride In tetrahydrofuran at 100℃; Heating / reflux; Stage #2: cyclohexanone With potassium hydride In tetrahydrofuran at 0℃; for 1.86667h; Heating / reflux; Stage #3: With acetic acid In tetrahydrofuran; water	91%
With potassium hydride; sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Reflux;	91%

: 530-93-8
1,2,3,4-tetrahydronaphthalen-2-one

: 616-38-6
carbonic acid dimethyl ester

: 31202-23-0
methyl 3,4-dihydro-2(2H)-naphthalenone-1-carboxylate

Conditions

Conditions	Yield
With sodium methylate In methanol at 80℃; for 2h;	100%
With sodium hydride In methanol; mineral oil at 80℃; for 3h; Inert atmosphere;	100%
With sodium hydride In benzene at 65 - 70℃; for 5h;	93%

: 98-86-2
acetophenone

: 616-38-6
carbonic acid dimethyl ester

: 614-27-7
methyl 3-oxo-3-phenylpropionate

Conditions

Conditions	Yield
With sodium hydride In toluene; mineral oil Reflux; Inert atmosphere;	100%
With sodium hydride In toluene; mineral oil at 95℃;	100%
Stage #1: carbonic acid dimethyl ester With sodium hydride In toluene; mineral oil Inert atmosphere; Sealed tube; Reflux; Stage #2: acetophenone In toluene; mineral oil for 0.5h; Inert atmosphere; Sealed tube;	98%

: 529-34-0
3,4-dihydronaphthalene-1(2H)-one

: 616-38-6
carbonic acid dimethyl ester

: 7442-52-6, 125117-36-4
methyl 1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate

Conditions

Conditions	Yield
With sodium hydride In methanol; mineral oil at 80℃; for 3h; Inert atmosphere; Further stages;	100%
With sodium hydride In methanol; toluene at 90℃; for 2h;	100%
With sodium hydride In toluene; mineral oil at 0 - 120℃; for 18h;	99%

: 2107-69-9
5,6-dimethoxy-1-indanone

: 616-38-6
carbonic acid dimethyl ester

: 119035-03-9
5,6-dimethoxy-2-methoxycarbonylindan-1-one

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran; mineral oil Reflux; Inert atmosphere;	100%
With sodium hydride In paraffin oil at 90℃;	92%
With sodium hydride In paraffin oil at 90℃; Inert atmosphere;	92%

: 502-49-8
cycloactanone

: 616-38-6
carbonic acid dimethyl ester

: 5452-73-3
methyl 2-oxocyclooctanecarboxylate

Conditions

Conditions	Yield
With sodium hydride In 1,4-dioxane at 90℃; Reflux;	100%
Stage #1: carbonic acid dimethyl ester With sodium hydride In tetrahydrofuran at 5 - 10℃; for 0.5h; Inert atmosphere; Stage #2: cycloactanone In tetrahydrofuran for 4.5h; Reflux; Inert atmosphere;	88%
Stage #1: carbonic acid dimethyl ester With sodium hydride In tetrahydrofuran at 5 - 10℃; for 0.5h; Stage #2: cycloactanone In tetrahydrofuran for 4.5h; Reflux;	88%

: 106-41-2
4-bromo-phenol

: 616-38-6
carbonic acid dimethyl ester

: 104-92-7
1-bromo-4-methoxy-benzene

Conditions

Conditions	Yield
With N,N'-dimethylimidazolium-2-carboxylate In acetonitrile at 160℃; for 2h; Microwave irradiation; Green chemistry;	100%
With layered double hydroxide - supported L-methionine at 180℃; for 6h; Autoclave; chemoselective reaction;	95%
With magnesium oxide In N,N-dimethyl-formamide at 170℃; for 0.5h; Microwave irradiation; Green chemistry;	95%

: 90-15-3
α-naphthol

: 616-38-6
carbonic acid dimethyl ester

: 2216-69-5
1-Methoxynaphthalene

Conditions

Conditions	Yield
With caesium carbonate at 120℃; for 4h;	100%
With 1,8-diazabicyclo[5.4.0]undec-7-ene at 90℃; for 16h; Product distribution; Further Variations:; Temperatures; Solvents; Pressures; reaction times; microwave irradiation;	99%
With N,N'-dimethylimidazolium-2-carboxylate In acetonitrile at 160℃; for 2h; Microwave irradiation; Green chemistry;	99%

: 78098-11-0
C19H26O3

: 616-38-6
carbonic acid dimethyl ester

: 131250-73-2
methyl 2-(ethylenedioxy)-1α,4aβ,8aβ-trimethyl-8-oxo-1,2,3,4,4a,6,7,8,8a,9-decahydrophenanthrene-7α-carboxylate

Conditions

Conditions	Yield
With potassium hydride; sodium hydride In 1,2-dimethoxyethane for 1h; Heating;	100%

: 616-38-6
carbonic acid dimethyl ester

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 22027-50-5
methyl 3-(4-methoxybenzoyl)acetate

Conditions

Conditions	Yield
With sodium hydride In toluene at 110℃;	100%
Stage #1: carbonic acid dimethyl ester With sodium hydride In toluene at 110℃; Stage #2: 1-(4-methoxyphenyl)ethanone In toluene at 110℃;	100%
With sodium hydride In toluene for 4h; Inert atmosphere; Reflux;	98%

: 616-38-6
carbonic acid dimethyl ester

: 108-95-2
phenol

: 100-66-3
methoxybenzene

Conditions

Conditions	Yield
N,N,N',N'-tetrabutyl-N''-methylguanidine at 160℃; for 4.5h;	100%
N,N,N',N'-tetrabutyl-N''-methylguanidine at 160℃; for 4.5h; Product distribution; other catalysts, other reaction conditions, other phenols;	100%
With tetrabutylammomium bromide; potassium carbonate at 93℃; for 5h;	99%

: 616-38-6
carbonic acid dimethyl ester

: 502-42-1
cycloheptanone

: 52784-32-4
2-(methoxycarbonyl)cycloheptanone

Conditions

Conditions	Yield
Stage #1: carbonic acid dimethyl ester With sodium hydride In toluene; mineral oil for 1h; Reflux; Stage #2: cycloheptanone In toluene; mineral oil for 3h; Reflux;	100%
Stage #1: carbonic acid dimethyl ester; cycloheptanone With sodium hydride In mineral oil; benzene for 3.84h; Inert atmosphere; Reflux; Stage #2: With acetic acid In mineral oil; benzene at 0℃; Inert atmosphere;	94%
With sodium hydride In benzene for 3h; Reflux;	94%

: 13336-31-7
4-methoxylindanone

: 616-38-6
carbonic acid dimethyl ester

: 131308-27-5
methyl 4-methoxy-2,3-dihydro-1-oxo-1H-indene-2-carboxylate

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran for 6h; Heating;	100%
With sodium hydride In mineral oil for 0.5h; Inert atmosphere; Schlenk technique; Reflux;
Stage #1: carbonic acid dimethyl ester With potassium tert-butylate; sodium hydride In tetrahydrofuran at 20℃; for 0.0833333h; Stage #2: 4-methoxylindanone In tetrahydrofuran at 20℃; for 2h;

: 121704-77-6
3-(prop-1-yloxy)acetophenone

: 616-38-6
carbonic acid dimethyl ester

: 150356-60-8
methyl 3-(prop-1-yloxy)benzoylacetate

Conditions

Conditions	Yield
With sodium hydride	100%
With sodium hydride Substitution;

: 616-38-6
carbonic acid dimethyl ester

: 586-37-8
1-(3-Methoxyphenyl)ethanone

: 779-81-7
methyl 3-(3-methoxyphenyl)-3-oxopropanoate

Conditions

Conditions	Yield
With sodium hydride In toluene; mineral oil for 2h; Inert atmosphere; Reflux;	100%
With sodium hydride In toluene for 4h; Inert atmosphere; Reflux;	97%
With sodium hydride at 80℃; for 0.116667h;	82%

: 52340-78-0
(R,R)-hydroxybenzoin

: 616-38-6
carbonic acid dimethyl ester

: 181783-75-5
(+)-(R,R)-1,2-diphenylethylene carbonate

Conditions

Conditions	Yield
With sodium hydroxide at 60℃; for 0.5h;	100%
With sodium hydroxide at 60℃; for 0.5h; Yield given;

: 616-38-6
carbonic acid dimethyl ester

: 286931-54-2
3'-chloro-2',5'-dimethoxyacetophenone

: 286931-55-3
methyl 3-(3-chloro-2,5-dimethoxyphenyl)-3-oxopropionate

Conditions

Conditions	Yield
With sodium methylate In methanol Acylation; Heating;	100%
With sodium methylate In methanol for 3h; Heating;	100%

: 616-38-6
carbonic acid dimethyl ester

: 3'-bromo-2',5'-dimethoxyacetophenone

: 286931-61-1
methyl 3-(3-bromo-2,5-dimethoxyphenyl)-3-oxopropionate

Conditions

Conditions	Yield
With sodium methylate In methanol Acylation; Heating;	100%
With sodium methylate In methanol for 3h; Heating;	100%

: 615-16-7
1,3-dihydro-2H-benzimidazol-2-one

: 616-38-6
carbonic acid dimethyl ester

: 3097-21-0
1,3-dimethyl-1,3-dihydrobenzimidazol-2-one

Conditions

Conditions	Yield
With lead(II) nitrate at 199.85℃; for 20h;	100%

: 1849-01-0
1-methyl-2-benzimidazolone

: 616-38-6
carbonic acid dimethyl ester

: 3097-21-0
1,3-dimethyl-1,3-dihydrobenzimidazol-2-one

Conditions

Conditions	Yield
With lead(II) nitrate at 199.85℃; for 20h;	100%

: 95-54-5
1,2-diamino-benzene

: 616-38-6
carbonic acid dimethyl ester

: 3097-21-0
1,3-dimethyl-1,3-dihydrobenzimidazol-2-one

Conditions

Conditions	Yield
With lead acetate at 199.85℃; for 20h;	100%

: 616-38-6
carbonic acid dimethyl ester

: 177476-32-3
C14H22O3

: 352354-89-3
C16H24O5

Conditions

Conditions	Yield
With methanol; sodium hydride at 60℃;	100%

: 616-38-6
carbonic acid dimethyl ester

: 100-46-9
benzylamine

: 5817-70-9
methyl N-benzylcarbamate

Conditions

Conditions	Yield
at 20℃; under 6000600 Torr; for 16h; neat (no solvent);	100%
lipase from Candida antarctica In toluene at 70℃; for 15h;	99%
With tetrabutylammomium bromide; L-proline at 20℃; for 3h; Catalytic behavior; Solvent; Green chemistry;	96%

: 104-47-2
p-methoxybenzylnitrile

: 616-38-6
carbonic acid dimethyl ester

: 30698-32-9
methyl 2-cyano-2-(4-methoxyphenyl) acetate

Conditions

Conditions	Yield
With sodium hydride In toluene; mineral oil at 80℃; for 5.5h;	100%
With sodium hydride In toluene at 80℃; for 5h; Inert atmosphere; Cooling with ice;	81%
With sodium methylate In methanol; toluene at 75 - 80℃; for 12h;	42%

: 616-38-6
carbonic acid dimethyl ester

: 3218-49-3
3,4-dichloro-benzeneacetonitrile

: 849589-04-4
cyano-(3,4-dichlorophenyl)acetic acid methyl ester

Conditions

Conditions	Yield
With sodium methylate In toluene Heating;	100%
With sodium methylate In toluene Heating;	100%
With sodium methylate In toluene at 85℃; for 3h;	93%

: 4133-34-0
7-methoxyl-2-tetralone

: 616-38-6
carbonic acid dimethyl ester

: 34865-33-3
methyl 7-methoxy-2-oxotetralin-1-carboxylate

Conditions

Conditions	Yield
With sodium hydride In benzene for 2h; Heating;	100%

: 98-53-3
4-tercbutyl-cyclohexanone

: 616-38-6
carbonic acid dimethyl ester

: 74851-58-4
5-tert-butyl-2-oxocyclohexanecarboxylic acid methyl ester

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 75℃;	100%
With sodium hydride In 1,4-dioxane at 90℃; Reflux; Inert atmosphere;	100%
With sodium hydride In tetrahydrofuran; mineral oil for 2h; Reflux;	99%
With potassium hydride; sodium hydride In tetrahydrofuran for 0.666667h; Heating;	95%

Dimethyl carbonate Chemical Properties

Molecule structure of Dimethyl carbonate (CAS NO.616-38-6):

IUPAC Name: Dimethyl carbonate
Molecular Weight: 90.07794 g/mol
Molecular Formula: C₃H₆O₃
Density: 1.024 g/cm³
Melting Point: 2-4 °C(lit.)
Boiling Point: 90.5 °C at 760 mmHg
Flash Point: 18.3 °C
Index of Refraction: 1.361
Molar Refractivity: 19.46 cm³
Molar Volume: 87.9 cm³
Surface Tension: 24.6 dyne/cm
Enthalpy of Vaporization: 33.05 kJ/mol
Vapour Pressure: 56 mmHg at 25 °C
Storage Temp.: flammables area
Water Solubility: 139 g/L
XLogP3-AA: 0.5
H-Bond Acceptor: 3
Rotatable Bond Count: 2
Exact Mass: 90.031694
MonoIsotopic Mass: 90.031694
Topological Polar Surface Area: 35.5
Heavy Atom Count: 6
Canonical SMILES: COC(=O)OC
InChI: InChI=1S/C3H6O3/c1-5-3(4)6-2/h1-2H3
InChIKey: IEJIGPNLZYLLBP-UHFFFAOYSA-N
EINECS: 210-478-4
Product Categories: Pharmaceutical Intermediates; Organics; Alternative Energy; Electrolytes; Materials Science; Anhydrous Grade SolventsSolvents; Solvent Bottles; Solvents; Sure/Seal Bottles; Carbonates; Carbonyl Compounds; Organic Building Blocks

Dimethyl carbonate Uses

Dimethyl carbonate (CAS NO.616-38-6) is a carbonate ester which has recently found use as a methylating reagent. It is also used as intermediate of herbicide.

Dimethyl carbonate Production

Dimethyl carbonate (CAS NO.616-38-6) is now prepared from catalytic oxidative carbonylation of methanol with carbon monoxide and oxygen, instead of from phosgene.

Dimethyl carbonate Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	800mg/kg (800mg/kg)	Food and Cosmetics Toxicology. Vol. 17, Pg. 361, 1979.
mouse	LD50	oral	6gm/kg (6000mg/kg)	Food and Cosmetics Toxicology. Vol. 17, Pg. 361, 1979.
rabbit	LD50	skin	> 5gm/kg (5000mg/kg)	Food and Cosmetics Toxicology. Vol. 17, Pg. 361, 1979.
rat	LD50	intraperitoneal	1600mg/kg (1600mg/kg)	Food and Cosmetics Toxicology. Vol. 17, Pg. 361, 1979.
rat	LD50	oral	13gm/kg (13000mg/kg)	Food and Cosmetics Toxicology. Vol. 17, Pg. 361, 1979.

Dimethyl carbonate Safety Profile

Hazard Codes: F
Risk Statements: 11
R11:Highly flammable.
Safety Statements: 9-16
S9:Keep container in a well-ventilated place.
S16:Keep away from sources of ignition.
RIDADR: UN 1161 3/PG 2
WGK Germany: 1
RTECS: FG0450000
HazardClass: 3
PackingGroup: II

Dimethyl carbonate Specification

Dimethyl carbonate (CAS NO.616-38-6) is also named as AI3-14705 ; HSDB 6928 ; Methyl carbonate ; Methyl carbonate ((MeO)₂CO) ; NSC 9371 ; Carbonic acid, dimethyl ester . Dimethyl carbonate is colourless liquid with a pleasant odor. It is slightly soluble in water and highly flammable. Dimethyl carbonate reacts with acids to liberate heat along with methanol and carbon dioxide. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction with caustic solutions. Flammable hydrogen is generated by mixing with alkali metals and hydrides. It may cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. It will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated.

Product Name

Dimethyl carbonate

Synthetic route

Dimethyl carbonate Chemical Properties

Dimethyl carbonate Uses

Dimethyl carbonate Production

Dimethyl carbonate Toxicity Data With Reference

Dimethyl carbonate Safety Profile

Dimethyl carbonate Specification

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