Ethyl difluoroacetate supplier

Name
Ethyl difluoroacetate
EINECS 207-223-4
CAS No. 454-31-9
Article Data46
CAS DataBase
Density 1.135 g/cm³
Solubility Slightly soluble in water
Melting Point
Formula C₄H₆F₂O₂
Boiling Point 76 °C at 760 mmHg
Molecular Weight 124.087
Flash Point 1.1 °C
Transport Information UN 1992
Appearance clear colorless liquid
Safety 45-36/37/39-26-16-27
Risk Codes 34-10
Molecular Structure
Hazard Symbols C, F, T, Xi
Synonyms Aceticacid, difluoro-, ethyl ester (6CI,7CI,8CI,9CI);2,2-Difluoroacetic acid ethylester;Difluoroacetic acid ethyl ester;Ethyl 2,2-difluoroacetate;Ethyl difluoroacetic;
PSA 26.30000
LogP 0.81460

Synthetic route

: 667-27-6
Ethyl bromodifluoroacetate

: 454-31-9
ethyl difluoroacetate

Conditions

Conditions	Yield
With 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-7-methylbenzo-[d]imidazole; [Zr(2,6-bis(5-methyl-3-phenyl-1H-pyrrol-2-yl)pyridine)2] In benzene-d6 for 2.5h; Catalytic behavior; UV-irradiation; Inert atmosphere; Schlenk technique;	98%
With 1,2,3-trimethoxybenzene; (3,5-dimethyl-2-(2-pyridyl)pyrrolide)3ZrCl; 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-7-methylbenzo-[d]imidazole In benzene-d6 at 33℃; for 0.5h; Time; Irradiation; Glovebox;	85%
With N,N,N,N,-tetramethylethylenediamine In dimethylsulfoxide-d6 at 20℃; for 15h; Irradiation;	41%
Stage #1: Ethyl bromodifluoroacetate With zinc In tetrahydrofuran at 20 - 50℃; for 1h; Inert atmosphere; Stage #2: With hydrogenchloride In tetrahydrofuran; water at 0℃; Product distribution / selectivity;	~ 90 %Chromat.
With hydrogen; nickel; triethylamine In ethanol at 80℃; under 3750.38 - 7500.75 Torr;

: 64-17-5
ethanol

: 2925-22-6
2,2-difluoroacetyl fluoride

: 454-31-9
ethyl difluoroacetate

Conditions

Conditions	Yield
With N,N-dimethyl acetamide for 4h; Product distribution / selectivity; Inert atmosphere; Sealed tube; Cooling with ice;	96%
With sodium carbonate at 5 - 20℃; for 1h; Product distribution / selectivity; Inert atmosphere;	77%
at 20℃; for 0.5h;

: 64-17-5
ethanol

: 667-50-5
Difluoroacetic acid N,N-dimethylamide

: 454-31-9
ethyl difluoroacetate

Conditions

Conditions	Yield
With sulfuric acid at 0 - 70℃; for 2h; Temperature;	93.98%

: 36589-84-1
1,1-diethoxy-2,2-difluoro-ethane

: 454-31-9
ethyl difluoroacetate

Conditions

Conditions	Yield
With dihydrogen peroxide; vanadia at 5℃; for 5h;	89.9%

: 512-51-6
1,1,2,2-tetrafluoroethyl ethyl ether

: 454-31-9
ethyl difluoroacetate

Conditions

Conditions	Yield
With sulfuric acid In water at 54 - 56℃; for 1h;	87%
Stage #1: Ethyl 1,1,2,2-tetrafluoroethyl ether With sulfuric acid; hydrogen fluoride In ethanol; water at -20 - 50℃; for 24h; Autoclave; Stage #2: With sodium hydrogencarbonate at 20℃; under 760.051 Torr; for 1h; Reagent/catalyst;	86%
With nitric acid
With sulfuric acid
With water; fluorinated γ-alumina at 180℃; for 0.0202778h; Product distribution / selectivity; Inert atmosphere; Gas phase;

: 64-17-5
ethanol

: 512-51-6
1,1,2,2-tetrafluoroethyl ethyl ether

: 454-31-9
ethyl difluoroacetate

Conditions

Conditions	Yield
With sulfuric acid; silica gel at 50℃; for 24h; Time; Autoclave;	86%

: 383-62-0
ethyl 2-chloro-2,2-difluoroacetate

: 454-31-9
ethyl difluoroacetate

Conditions

Conditions	Yield
With palladium on activated charcoal; hydrogen; triethylamine In ethanol at 30℃; under 750.075 - 3000.3 Torr;	75%
With zinc In N,N-dimethyl-formamide at 70℃; Yield given;

: 592-76-7
1-Heptene

: 7648-30-8
ethyl 2,2-difluoro-2-iodoacetate

A: 454-31-9
ethyl difluoroacetate

B: 127224-10-6
Ethyl 2,2-Difluoro-4-iodononanoate

Conditions

Conditions	Yield
With hydroquinone; nickel dichloride; zinc In tetrahydrofuran; water 1) RT, 15 min, 2) RT, 20 min;	A 70% B 17%

...Expand

: 383-62-0
ethyl 2-chloro-2,2-difluoroacetate

A: 381-73-7
Difluoroacetic acid

B: 454-31-9
ethyl difluoroacetate

C: 76-04-0
2-chloro-2,2-difluoroacetic acid

Conditions

Conditions	Yield
With ethanol; zinc for 1 - 3h; Product distribution / selectivity; Heating / reflux;	A 9.7% B 61.6% C 0.4%

...Expand

: 64-17-5
ethanol

: 359-12-6
difluoroacetonitrile

: 454-31-9
ethyl difluoroacetate

Conditions

Conditions	Yield
With sulfuric acid In water at 10 - 120℃; for 14h;	57%

: 617-35-6
2-oxo-propionic acid ethyl ester

: 667-27-6
Ethyl bromodifluoroacetate

A: 454-31-9
ethyl difluoroacetate

B: 2,2,3,3-tetrafluoro-4-hydroxy-4-methyl-pentanedioic acid diethyl ester

Conditions

Conditions	Yield
Stage #1: 2-oxo-propionic acid ethyl ester; Ethyl bromodifluoroacetate In N,N-dimethyl-formamide at -20℃; Stage #2: With Tetrakis(dimethylamino)ethylen In N,N-dimethyl-formamide at -20 - 20℃;	A n/a B 25%

...Expand

: 667-27-6
Ethyl bromodifluoroacetate

: 58837-16-4
1,3,5-tris(4-methoxybenzyl)hexahydro-1,3,5-triazine

A: 454-31-9
ethyl difluoroacetate

B: 1-(4'-methoxybenzyl)-3,3-difluoroazetidin-2-one

C: 3,3,5,5-tetrafluoro-1-(4-methoxy-benzyl)-piperidine-2,4-dione

D: 5,5-difluoro-1,3-bis-(4-methoxy-benzyl)-tetrahydro-pyrimidin-4-one

Conditions

Conditions	Yield
Stage #1: Ethyl bromodifluoroacetate With chloro-trimethyl-silane; zinc In tetrahydrofuran for 0.416667h; Stage #2: 1,3,5-tris(4-methoxybenzyl)hexahydro-1,3,5-triazine In tetrahydrofuran at 25℃; for 3h;	A n/a B 25% C n/a D n/a

...Expand

: 535-15-9
ethyl 1,1-dichloroacetate

: 454-31-9
ethyl difluoroacetate

Conditions

Conditions	Yield
With potassium fluoride In ethanol; water at 100℃; for 40h; Solvent; Concentration;	21%
With potassium fluoride; C6H9BO4 In ISOPROPYLAMIDE at 20 - 75℃; Halex reaction;

: 75-77-4
chloro-trimethyl-silane

: 383-63-1
ethyl trifluoroacetate,

A: 454-31-9
ethyl difluoroacetate

B: 205865-67-4
α-(trimethylsilyl)difluoroacetic acid ethyl ester

C: 565214-84-8
trifluoroacetyltrimethylsilane ethyltrimethylsilyl ketal

D: 2,3-diethoxy-1,1,1,4,4,4-hexafluoro-2,3-bis-trimethylsilanyloxy-butane

Conditions

Conditions	Yield
With tetrabutylammomium bromide In tetrahydrofuran at -25℃; Electrochemical reaction; Further byproducts given;	A 8% B 8 % Spectr. C 33 % Spectr. D 1 % Spectr.

...Expand

: 381-73-7
Difluoroacetic acid

: 64-17-5
ethanol

: 454-31-9
ethyl difluoroacetate

Conditions

Conditions	Yield
With sulfuric acid

: 557-99-3
acetyl fluoride

: 454-31-9
ethyl difluoroacetate

Conditions

Conditions	Yield
With fluorine at 100℃; ueber Kupferdrahtnetz und Umsetzen der Reaktionsprodukte mit absol.Aethanol;

: 186581-53-3, 908094-01-9
diazomethane

: 60-29-7
diethyl ether

: 17976-35-1
1,1,2,3,4,4-hexafluoro-2-butene

A: 433-53-4
difluoroacetic acid methyl ester

B: 454-31-9
ethyl difluoroacetate

Conditions

Conditions	Yield
With potassium hydroxide; potassium permanganate 1.) 60 degC, water; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 381-73-7
Difluoroacetic acid

: 141-52-6
sodium ethanolate

: 454-31-9
ethyl difluoroacetate

Conditions

Conditions	Yield
With N-(2-chloro-1,1,2-trifluoroethyl)diethylamine; sodium fluoride 1.) -78 deg C, 15 min, 2.) triglyme; Yield given. Multistep reaction;

: 383-63-1
ethyl trifluoroacetate,

A: 74-84-0
ethane

B: 144-49-0
Fluoroacetic acid

C: 459-72-3
ethyl 2-fluoroacetate

D: 454-31-9
ethyl difluoroacetate

E: 141-78-6
ethyl acetate

Conditions

Conditions	Yield
With N,N,N,N,N,N-hexamethylphosphoric triamide for 2h; Quantum yield; Irradiation;

...Expand

: 512-51-6
1,1,2,2-tetrafluoroethyl ethyl ether

: 7664-93-9
sulfuric acid

: 454-31-9
ethyl difluoroacetate

: 64-67-5
diethyl sulfate

difluoroacetate_of sodium: difluoroacetate_of sodium

: 454-31-9
ethyl difluoroacetate

: 557-99-3
acetyl fluoride

fluorine: fluorine

copper wire: copper wire

A: 459-72-3
ethyl 2-fluoroacetate

B: 454-31-9
ethyl difluoroacetate

C: 383-63-1
ethyl trifluoroacetate,

Conditions

Conditions	Yield
at 100℃; Umsetzen der Reaktionsprodukte mit absol.Aethanol bei -80grad,zuletzt bei Siedetemperatur;

...Expand

: 780-25-6
N-benzylidene benzylamine

: 205865-67-4
α-(trimethylsilyl)difluoroacetic acid ethyl ester

A: 454-31-9
ethyl difluoroacetate

B: 53986-95-1
N-benzylidene-α-(trimethylsilyl)benzylamine

Conditions

Conditions	Yield
With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium fluoride at 50℃; for 12h;

...Expand

: 667-27-6
Ethyl bromodifluoroacetate

: 140-88-5
ethyl acrylate

A: 454-31-9
ethyl difluoroacetate

B: 428-97-7
2,2-difluoroglutaric acid diethyl ester

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; water; copper In tetrahydrofuran Michael Addition;	A 10 %Spectr. B 52 %Spectr.

...Expand

: 667-27-6
Ethyl bromodifluoroacetate

: 98-80-6
phenylboronic acid

A: 454-31-9
ethyl difluoroacetate

B: 2248-46-6
ethyl 2,2-difluoro-2-phenylacetate

Conditions

Conditions	Yield
With 2,2':6,2''-terpyridine; nickel chloride dimethyl ether; potassium carbonate In 1,4-dioxane at 80℃; for 8h; Schlenk technique; Inert atmosphere;	A 7 %Spectr. B 1 %Spectr.
With [2,2]bipyridinyl; [1,1'-bis(diphenylphosphino)ferrocene]nickel(II) chloride; potassium carbonate In 1,4-dioxane at 80℃; for 8h; Reagent/catalyst; Solvent; Schlenk technique; Inert atmosphere;	A 6 %Spectr. B 89 %Spectr.

...Expand

: 88-12-0
1-ethenyl-2-pyrrolidinone

: 667-27-6
Ethyl bromodifluoroacetate

: 5122-94-1
4-biphenylboronic acid

A: 454-31-9
ethyl difluoroacetate

B: ethyl 4-([1,1'-biphenyl]-4-yl)-2,2-difluoro-4-(2-oxopyrrolidin-1-yl)butanoate

C: 73789-98-7
2-([1,1'-biphenyl]-4-yl)-2,2-difluoroacetic acid ethyl ester

Conditions

Conditions	Yield
With (1,2-dimethoxyethane)dichloronickel(II); 4,4'-dibromo-2,2'-bipyridine; potassium carbonate In tetrahydrofuran at 80℃; for 24h; Reagent/catalyst; Solvent; Schlenk technique; Inert atmosphere;	A 15 %Spectr. B 53 %Spectr. C 13 %Spectr.

...Expand

: 88-12-0
1-ethenyl-2-pyrrolidinone

: 667-27-6
Ethyl bromodifluoroacetate

: 5122-94-1
4-biphenylboronic acid

A: 454-31-9
ethyl difluoroacetate

B: ethyl 4-([1,1'-biphenyl]-4-yl)-2,2-difluoro-4-(2-oxopyrrolidin-1-yl)butanoate

C: C10H13F2NO3

D: 73789-98-7
2-([1,1'-biphenyl]-4-yl)-2,2-difluoroacetic acid ethyl ester

Conditions

Conditions	Yield
With bis(triphenylphosphine)nickel(II) chloride; 4,4'-Dimethoxy-2,2'-bipyridin; potassium carbonate In tetrahydrofuran at 80℃; for 24h; Concentration; Reagent/catalyst; Solvent; Schlenk technique; Inert atmosphere;	A 13 %Spectr. B 49 %Spectr. C 7 %Spectr. D 36 %Spectr.

...Expand

: 383-62-0
ethyl 2-chloro-2,2-difluoroacetate

A: 359-13-7
difluoroethanol

B: 454-31-9
ethyl difluoroacetate

Conditions

Conditions	Yield
With palladium on activated charcoal; hydrogen; triethylamine In ethanol at 45℃; under 7500.75 - 30003 Torr; for 5h; Temperature; Time; Pressure;

: 7648-30-8
ethyl 2,2-difluoro-2-iodoacetate

: 454-31-9
ethyl difluoroacetate

Conditions

Conditions	Yield
With palladium on activated charcoal; hydrogen; triethylamine In tetrahydrofuran at 100℃; under 750.075 - 15001.5 Torr;
With diethylzinc In hexane; [D3]acetonitrile at -20℃; for 8h; Schlenk technique; Inert atmosphere;

: 454-31-9
ethyl difluoroacetate

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at -78℃; for 2.75h;	100%
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at -78℃; for 3h;	60%
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at -78℃; for 3h; Reagent/catalyst; Solvent;	60%

: 454-31-9
ethyl difluoroacetate

: 90-76-6, 90-77-7, 530-23-4, 579-32-8, 579-33-9, 643-68-5, 2596-19-2, 6490-68-2, 6490-70-6, 6490-72-8, 6490-73-9, 6490-74-0, 14196-84-0, 14196-86-2, 14257-69-3, 58381-21-8
D-mannosamine

: N-difluoroacetyl-D-mannosamine

Conditions

Conditions	Yield
In methanol at 20℃; for 16h;	100%

: 454-31-9
ethyl difluoroacetate

: C13H23NO3

: C15H23F2NO4

Conditions

Conditions	Yield
With potassium tert-butylate In toluene at 0 - 20℃; for 2h; Inert atmosphere;	100%
With potassium tert-butylate In toluene at 0 - 20℃; for 2h; Inert atmosphere;	100%
With potassium tert-butylate In toluene at 0 - 20℃; Inert atmosphere;	100%
With potassium tert-butylate In toluene at 0 - 20℃; for 2h; Inert atmosphere;	100%

: 454-31-9
ethyl difluoroacetate

: C13H23NO3

: C15H23F2NO4

Conditions

Conditions	Yield
With potassium tert-butylate In toluene at 0 - 20℃; for 2h; Inert atmosphere;	100%

: 681425-32-1
(S)-{(1α,5α,6α)-3-[4-(5-aminomethyl-2-oxooxazolidin-3-yl)-2,6-difluorophenyl]-3-azabicyclo[3.1.0]hex-6-yl}carbamic acid tert-butyl ester

: 454-31-9
ethyl difluoroacetate

: 681425-33-2
(S)-[(1α,5α,6α)-3-(4-{5-[(2,2-difluoroacetylamino)methyl]-2-oxooxazolidin-3-yl}-2,6-difluorophenyl)-3-azabicyclo[3.1.0]hex-6-yl]carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With triethylamine In methanol at 20℃; for 15h;	99%
With triethylamine In methanol at 20℃; for 15h;	99%

: 454-31-9
ethyl difluoroacetate

: 97004-04-1
5-(aminomethyl)-2-chloropyridine

: 1135440-09-3
N-(2-chloro-5-aminomethylpyridine)-1,1-difluoroacetamide

Conditions

Conditions	Yield
at 100℃; for 1h; Reflux;	99%

: 454-31-9
ethyl difluoroacetate

: 76-05-1
trifluoroacetic acid

A: 381-73-7
Difluoroacetic acid

B: 383-63-1
ethyl trifluoroacetate,

Conditions

Conditions	Yield
at 85℃; Product distribution / selectivity;	A 99% B n/a

...Expand

: 454-31-9
ethyl difluoroacetate

: C14H23NO3

: C16H23F2NO4

Conditions

Conditions	Yield
With potassium tert-butylate In toluene at 0 - 20℃; for 2h; Inert atmosphere;	99%
With potassium tert-butylate In toluene at 0 - 20℃; Inert atmosphere;	99%

: 454-31-9
ethyl difluoroacetate

: C13H22FNO3

: C15H22F3NO4

Conditions

Conditions	Yield
With potassium tert-butylate In toluene at 0 - 20℃; Inert atmosphere;	99%

: 75-77-4
chloro-trimethyl-silane

: 119-61-9
benzophenone

: 454-31-9
ethyl difluoroacetate

: 14629-59-5
diphenylmethyl trimethylsilyl ether

Conditions

Conditions	Yield
With magnesium In 1-methyl-pyrrolidin-2-one at 20℃; Inert atmosphere;	98%

...Expand

: 858643-92-2
tert-butyl 3-acetylpiperidine-1-carboxylate

: 454-31-9
ethyl difluoroacetate

: tert-butyl 3-(4,4-difluoro-3-oxobutanoyl)piperidine-1-carboxylate

Conditions

Conditions	Yield
With potassium tert-butylate In benzene at 0 - 20℃; for 5h; Inert atmosphere;	98%
With potassium tert-butylate In benzene at 0 - 20℃; for 5h; Inert atmosphere;	97%

: 454-31-9
ethyl difluoroacetate

: 64-04-0
phenethylamine

: 2,2-difluoro-N-(2-phenylethyl)acetamide

Conditions

Conditions	Yield
In dichloromethane for 16h; Reflux; Inert atmosphere;	98%

: 454-31-9
ethyl difluoroacetate

: 51-45-6
histamine

: 2,2-difluoro-N-[2-(1H-imidazol-4-yl)ethyl]acetamide

Conditions

Conditions	Yield
In dichloromethane for 16h; Reflux; Inert atmosphere;	98%

: 454-31-9
ethyl difluoroacetate

: 484-51-5
5-acetyl-6-hydroxy-4,7-dimethoxybenzofuran

: 376384-40-6
7-(difluoromethyl)-7-hydroxy-4,9-dimethoxy-6,7-dihydro-5H-furo[3,2-g]chromen-5-one

Conditions

Conditions	Yield
With lithium hydride In tetrahydrofuran Heating;	97%

: 454-31-9
ethyl difluoroacetate

: 683-08-9
Diethyl methylphosphonate

: 1023327-32-3
diethyl (3,3-difluoro-2-oxopropyl)phosphonate

Conditions

Conditions	Yield
Stage #1: Diethyl methylphosphonate With n-butyllithium In tetrahydrofuran; hexane at -95℃; for 1h; Inert atmosphere; Stage #2: ethyl difluoroacetate In tetrahydrofuran; hexane at -95 - -90℃; for 1h; Inert atmosphere;	97%
Stage #1: Diethyl methylphosphonate With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 1h; Stage #2: ethyl difluoroacetate In tetrahydrofuran at -78 - 0℃; Further stages.;	82%
With n-butyllithium In tetrahydrofuran; hexane at -78 - -65℃; for 3h;

: 454-31-9
ethyl difluoroacetate

: 359-38-6
2,2-difluoroacetamide

Conditions

Conditions	Yield
With ammonia In ethanol at 0 - 25℃; for 2.5h;	96%
With ammonia

: 454-31-9
ethyl difluoroacetate

: 455-91-4
1-(3-fluoro-4-methoxyphenyl)ethanone

: 170570-77-1
4,4-difluoro-1-(3-fluoro-4-methoxyohenyl)-butane-1,3-dione

Conditions

Conditions	Yield
With hydrogenchloride; sodium methylate In tert-butyl methyl ether	96%
With hydrogenchloride; sodium methylate In tert-butyl methyl ether	96%
With hydrogenchloride; sodium methylate In tert-butyl methyl ether	96%

: 64-18-6
formic acid

: 454-31-9
ethyl difluoroacetate

A: 381-73-7
Difluoroacetic acid

B: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
sulfuric acid at 70℃; Product distribution / selectivity;	A 96% B n/a

...Expand

: 454-31-9
ethyl difluoroacetate

: 141-78-6
ethyl acetate

: 352-24-9
ethyl 4,4-difluoro-3-oxobutyrate

Conditions

Conditions	Yield
Stage #1: ethyl acetate With sodium ethanolate at 25℃; Stage #2: ethyl difluoroacetate at 10 - 65℃; Stage #3: With sulfuric acid; water at 20 - 25℃; for 0.333333h; Product distribution / selectivity;	95.5%
With multielement hydrotalcite at 55℃; for 8h; Catalytic behavior; Temperature; Reagent/catalyst; Green chemistry;	88.9%
With lithium diisopropyl amide In diethyl ether at -70℃; for 4h;	82%

: 454-31-9
ethyl difluoroacetate

: 536-74-3
phenylacetylene

: 117710-72-2
1,1-difluoro-4-phenyl-3-butyn-2-one

Conditions

Conditions	Yield
Stage #1: phenylacetylene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 3h; Inert atmosphere; Stage #2: ethyl difluoroacetate With boron trifluoride diethyl etherate In tetrahydrofuran; hexane at -78℃; for 2h; Inert atmosphere;	95%
With n-butyllithium; boron trifluoride diethyl etherate 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 90 min; Yield given. Multistep reaction;
With n-butyllithium; boron trifluoride diethyl etherate 1.) hexane, THF, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 1.5 h; Yield given. Multistep reaction;
With n-butyllithium; boron trifluoride diethyl etherate

: 51-17-2
benzoimidazole

: 454-31-9
ethyl difluoroacetate

: 84941-15-1
1-(difluoromethyl)-1H-benzo[d]imidazole

Conditions

Conditions	Yield
With potassium hydroxide In acetonitrile at 60℃; for 6h; Concentration; Solvent; Temperature; Sealed tube;	95%

: 454-31-9
ethyl difluoroacetate

: 359-13-7
difluoroethanol

Conditions

Conditions	Yield
With hydrogen at 110℃; under 3750.38 - 15001.5 Torr; for 4h; Temperature; Pressure; Autoclave;	93.3%
With C39H53ClN2P2Ru; potassium methanolate; hydrogen In tetrahydrofuran at 20℃; under 38002.6 Torr; for 16h; Glovebox; Autoclave;	93%
With lithium aluminium tetrahydride In tetrahydrofuran at -10℃; for 1h;	44.6%

: 454-31-9
ethyl difluoroacetate

: 23699-74-3
1-(2-anilinophenyl)ethan-1-one

: 837364-34-8
2-(difluoromethyl)-1-phenylquinolin-4(1H)-one

Conditions

Conditions	Yield
With lithium hydride In tetrahydrofuran for 1h; Heating;	93%

: 454-31-9
ethyl difluoroacetate

: 54696-05-8
4'-benzyloxy-acetophenone

: 4,4-difluoromethyl-1-(4-benzyloxyphenyl)-butane-1,3-dione

Conditions

Conditions	Yield
With sodium methylate In methanol	93%

: 454-31-9
ethyl difluoroacetate

: 932-66-1
1-cyclohexenyl methyl ketone

: 4,4-difluoro-1-[2-cyclohexenyl]-butane-1,3-dione

Conditions

Conditions	Yield
With hydrogenchloride; sodium methylate	93%
With hydrogenchloride; sodium methylate	93%

: 454-31-9
ethyl difluoroacetate

: C10H11FN2O

: C12H11F3N2O2

Conditions

Conditions	Yield
With dmap In methanol at 20℃; for 12h;	92.8%

Ethyl difluoroacetate Chemical Properties

IUPAC Name: Ethyl 2,2-difluoroacetate
Following is the structure of Aceticacid, 2,2-difluoro-, ethyl ester (CAS NO.454-31-9):

Molecular Formula: C₄H₆F₂O₂
Molecular Weight: 124.09g/mol
Mol File: 454-31-9.mol
EINECS: 207-223-4
Flash Point: 1.1 °C
Density: 1.135 g/cm³
Refractive index: 1.3465-1.3485
Surface Tension: 20.4 dyne/cm
Boiling point: 76 °C at 760 mmHg
Enthalpy of Vaporization: 31.71 kJ/mol
Vapour Pressure: 103 mmHg at 25°C
XLogP3-AA: 0.9
H-Bond Acceptor: 4
Molar Refractivity: 22.64 cm³
Molar Volume: 109.3 cm³
Appearance of Aceticacid, 2,2-difluoro-, ethyl ester (CAS NO.454-31-9): Colorless to light brown clear liquid
Product Categories of Aceticacid, 2,2-difluoro-, ethyl ester (CAS NO.454-31-9): Pharmaceutical Intermediates; Fluoro-Aliphatics ; Organic Fluorides; Fluorochemicals; Fluorinated Building Blocks; Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds; Synthetic Organic Chemistry; C2 to C5; Carbonyl Compounds; Esters
Canonical SMILES: CCOC(=O)C(F)F
InChI: InChI=1S/C4H6F2O2/c1-2-8-4(7)3(5)6/h3H,2H2,1H3
InChIKey: GZKHDVAKKLTJPO-UHFFFAOYSA-N

Ethyl difluoroacetate Safety Profile

Safety Information of Aceticacid, 2,2-difluoro-, ethyl ester (CAS NO.454-31-9):
Hazard Codes: C Corrosive ,F,T Toxic ,Xi Irritant
Risk Statements: 34-10
10: Flammable
34: Causes burns
Safety Statements: 45-36/37/39-26-16-27
16: Keep away from sources of ignition - No smoking
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
27: Take off immediately all contaminated clothing
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
RIDADR: 1992
Hazard Note: Flammable
HazardClass: 3
PackingGroup: III

Ethyl difluoroacetate Specification

Aceticacid, 2,2-difluoro-, ethyl ester , its CAS NO. is 454-31-9, the synonyms are Ethyl difluoroacetate ; and Acetic acid, difluoro-, ethyl ester .

Product Name

Ethyl difluoroacetate

Synthetic route

Ethyl difluoroacetate Chemical Properties

Ethyl difluoroacetate Safety Profile

Ethyl difluoroacetate Specification

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