Conditions | Yield |
---|---|
With bis(2,2'-bipyridyl) copper(II) permanganate In acetone for 0.1h; Ambient temperature; | 100% |
With 4 A molecular sieve; tetrabutylammonium perchlorate; Ru-Cu-Al-hydrotalcite In toluene at 60℃; for 3h; | 100% |
With potassium carbonate In toluene at 70℃; for 2.5h; Reagent/catalyst; | 100% |
Conditions | Yield |
---|---|
In diethyl ether for 1h; Product distribution; Irradiation; photochemical debromination was investigated; | 100% |
furfural
Conditions | Yield |
---|---|
With hydrogenchloride for 0.0416667h; Product distribution; Ambient temperature; pH = 4-6, regeneration of aldehyde; | 100% |
Conditions | Yield |
---|---|
With sulphated zirconia In acetonitrile at 60℃; for 2h; Microwave irradiation; | 100% |
With Montmorillonite K10 In dichloromethane for 0.333333h; Heating; | 98% |
With water; Sulfate; titanium(IV) oxide In dichloromethane for 0.0833333h; Deacetylation; Heating; | 97% |
2-(1,3-dithian-2-yl)furan
furfural
Conditions | Yield |
---|---|
With dihydrogen peroxide; iodine; sodium dodecyl-sulfate In water at 20℃; for 1h; Micellar solution; | 100% |
With indium(III) trifluoride; water In acetonitrile for 3.5h; Reflux; chemoselective reaction; | 93% |
With 2,4,4,6-Tetrabromo-2,5-cyclohexadien-1-one; dihydrogen peroxide In water; acetonitrile at 20℃; for 0.75h; | 90% |
With eosin y In water; acetonitrile at 20℃; for 4h; Irradiation; | 82% |
With ammonium iodide; dihydrogen peroxide; sodium dodecyl-sulfate In water at 20℃; for 0.333333h; micellar medium; |
furfural tosylhydrazone
furfural
Conditions | Yield |
---|---|
With Cr-MCM-41 zeolite on silica gel for 0.1h; microwave irradiation; | 98% |
With benzeneseleninic anhydride In tetrahydrofuran at 40 - 50℃; for 2h; | 88% |
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane; water at 20℃; for 2h; Oxidation; oxidative cleavage; | 80% |
Conditions | Yield |
---|---|
With sulfonated graphitic carbon nitride In water at 100℃; for 0.5h; Solvent; Temperature; | 96% |
With Sulfonated graphene at 150℃; for 0.666667h; Temperature; Sealed tube; | 96% |
With hydrogenchloride; 5-methyl-dihydro-furan-2-one In water at 224.84℃; under 28443.9 Torr; for 0.0375h; Kinetics; Temperature; Reagent/catalyst; Concentration; Flow reactor; | 93% |
Conditions | Yield |
---|---|
With Montmorillonite K 10; water In acetone for 0.5h; Heating; | 96% |
With aluminum oxide; Oxone for 0.03h; Hydrolysis; Microwave irradiation; | 93% |
With iron(III) chloride hexahydrate; acetaldehyde In dichloromethane at 20℃; for 0.25h; | 90% |
Conditions | Yield |
---|---|
With water; Dess-Martin periodane In dichloromethane at 5℃; for 0.333333h; | 95% |
With silica gel; iron(III) chloride for 0.0133333h; microwave irradiation; | 92% |
With bis(pyridine)silver(I) permanganate In dichloromethane for 0.0833333h; Ambient temperature; | 90% |
2-(Iodomethyl)tetrahydrofuran
furfural
Conditions | Yield |
---|---|
With oxygen; kieselguhr; copper(l) chloride In hexane for 2h; Oxidation; Heating; | 93% |
furfural
Conditions | Yield |
---|---|
With aluminium trichloride; 1-benzyl-4-aza-1-azoniabicyclo[2.2.2]octane dichromate at 20℃; for 0.0125h; | 93% |
With sodium perborate In acetic acid at 40℃; for 1h; Oxidation; |
Conditions | Yield |
---|---|
Stage #1: 2-(1,3-dithiolan-2-yl)furan In ethanol at 20℃; Stage #2: With water In ethanol at 20℃; | 93% |
With indium(III) trifluoride; water In acetonitrile for 3.5h; Reflux; chemoselective reaction; | 89% |
With indium (III) iodide; dihydrogen peroxide In water; toluene at 20℃; for 15h; Inert atmosphere; Sealed tube; |
2-(furan-2-yl)-1,3-oxathiolane
furfural
Conditions | Yield |
---|---|
Stage #1: 2-(furan-2-yl)-1,3-oxathiolane In ethanol at 20℃; Stage #2: With water In ethanol at 20℃; | 93% |
With copper(II) nitrate monohydrate at 90℃; for 0.333333h; | 85% |
Conditions | Yield |
---|---|
With potassium carbonate In chloroform at 20℃; for 24h; Irradiation; Inert atmosphere; | 93% |
3-bromofurfural
furfural
Conditions | Yield |
---|---|
In diethyl ether for 1h; Product distribution; Irradiation; photochemical debromination was investigated; | 92% |
D-Arabinose
furfural
Conditions | Yield |
---|---|
With Dowex 50Wx8-100 ion-exchange resin at 100℃; for 6h; Ionic liquid; Sealed tube; | 92% |
With silicoaluminophosphate-44 In water; toluene at 170℃; for 8h; | 63% |
With 1-butyl-3-methylimidazolium tetrachloridoferrate(III) In water; butanone at 160℃; for 3h; | 50.7% |
Conditions | Yield |
---|---|
With nickel-doped graphene carbon nitride nanoparticles; air In ethanol at 25℃; for 8h; Irradiation; Green chemistry; | 92% |
With oxygen In acetonitrile at 20℃; for 18h; Irradiation; | 95 %Spectr. |
With tert.-butylhydroperoxide; C29H25Cl2N4Ru(1+)*F6P(1-) In acetonitrile at 60℃; for 3h; Schlenk technique; Inert atmosphere; | 71 %Chromat. |
Conditions | Yield |
---|---|
With 1-methyl-3-(4-sulfobutyl)-1H-imidazol-3-ium hydrogensulfate; 4-methyl-2-pentanone In water at 150℃; under 760.051 Torr; for 0.416667h; Autoclave; | 91.4% |
Conditions | Yield |
---|---|
With D-Xylose In water at 180℃; for 0.666667h; Temperature; Reagent/catalyst; | 91.4% |
Conditions | Yield |
---|---|
With phosphorus and fluorine co-doped amorphous carbon nitride In tetrahydrofuran; water at 130℃; for 5h; | 91% |
With hydrogen In water at 150℃; under 750.075 Torr; Temperature; | 87.6% |
With vanadyl pyrophosphate In water; toluene at 170℃; for 6h; | 56% |
Conditions | Yield |
---|---|
With aluminum oxide; potassium permanganate In dichloromethane at 20℃; | 90% |
tert-butyldimethyl(2,2,2-trichloro-1-furan-2-ylethoxy)silane
furfural
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride In tetrahydrofuran; N,N-dimethyl-formamide at 50℃; | 90% |
Conditions | Yield |
---|---|
With water; 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate In acetonitrile at 20℃; for 8h; | 90% |
2-(bis(phenylthio)methyl)furan
furfural
Conditions | Yield |
---|---|
With indium(III) trifluoride; water In acetonitrile for 3h; Reflux; chemoselective reaction; | 90% |
Conditions | Yield |
---|---|
With Dowex 50Wx8-200 ion-exchange resin at 100℃; for 3h; Ionic liquid; Sealed tube; | 90% |
With 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate; copper dichloride at 120℃; for 0.3h; Reagent/catalyst; Ionic liquid; | 67 %Chromat. |
Conditions | Yield |
---|---|
With indium(III) trifluoride; water In acetonitrile for 2.5h; Reflux; chemoselective reaction; | 89% |
Conditions | Yield |
---|---|
With pentacoordinated hydrogenosilane 1 | 87% |
With bis(triphenylphosphine)copper(I) tetrahydroborate; triphenylphosphine In acetone at 25℃; for 1h; | 78% |
With tert-butyl isocyanide; CpRu(PiPr3)(CH3CN)2PF6; Dimethylphenylsilane In [(2)H6]acetone at 20℃; for 24h; chemoselective reaction; | 100 %Spectr. |
With tert-butyl isocyanide; CpRu(PiPr3)(CH3CN)2PF6; Dimethylphenylsilane In [(2)H6]acetone at 20℃; for 24h; chemoselective reaction; | Ca. 100 %Spectr. |
Conditions | Yield |
---|---|
With indium(III) trifluoride; water In acetonitrile for 2h; Reflux; chemoselective reaction; | 87% |
indium(III) chloride In methanol; water for 2h; Heating; | 85% |
Conditions | Yield |
---|---|
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene In dichloromethane at 0 - 20℃; for 0.333333h; Inert atmosphere; Green chemistry; | 87% |
With pyridoxal 5'-phosphate; sodium pyruvate In aq. phosphate buffer at 30℃; pH=7.5; Reagent/catalyst; Enzymatic reaction; |
Conditions | Yield |
---|---|
With manganese triacetate In benzene for 1h; Heating; | 86% |
With antimonypentachloride In dichloromethane at 20℃; for 2.3h; | 75% |
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol for 0.025h; microwave irradiation; | 100% |
With sodium hydroxide In ethanol; water at 20℃; for 24h; Inert atmosphere; Green chemistry; | 99% |
aluminum oxide for 0.0416667h; microwave irradiation; | 98% |
Conditions | Yield |
---|---|
In methanol at 20℃; for 24h; | 100% |
In methanol at 20℃; for 24h; | 100% |
In methanol at 20℃; | 85% |
Conditions | Yield |
---|---|
With sodium sulfate In benzene for 0.5h; Ambient temperature; | 100% |
In methanol at 20℃; for 24h; | 100% |
In methanol at 20℃; for 24h; | 100% |
Conditions | Yield |
---|---|
With copper(II) bis(trifluoromethanesulfonate) In water at 20℃; for 0.0166667h; | 100% |
With aluminum oxide for 5h; Milling; | 100% |
sodium hydrogen sulfate; silica gel at 56 - 58℃; for 0.0244444h; microwave irradiation; | 98% |
furfural
phosphonic acid diethyl ester
diethyl (hydroxy(furan-2-yl)methyl)phosphonate
Conditions | Yield |
---|---|
With triethylamine In neat (no solvent) at 20℃; Pudovik Reaction; Inert atmosphere; | 100% |
With triethylamine at 50℃; Pudovik Reaction; Inert atmosphere; Sealed tube; | 100% |
With 2-tert-butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine supported on polystyrene In neat (no solvent) at 30℃; for 3h; Pudovik Reaction; Green chemistry; | 99% |
furfural
ethyl 2-cyanoacetate
ethyl (E)-2-cyano-3-(2-furyl)-2-propenoate
Conditions | Yield |
---|---|
With L-proline for 0.0333333h; Knoevenagel condensation; microwave irradiation; | 100% |
ytterbium(III) perfluorooctanesulfonate In toluene at 80℃; for 3h; Knoevenagel condensation; | 99% |
With polyacrylonitrile fiber modified with triethylenetetramine In water at 50℃; for 1.5h; Knoevenagel condensation; | 99% |
furfural
naphthalen-2-ylamine
(E)-1-(furan-2-yl)-N-(naphthalen-2-yl)methanimine
Conditions | Yield |
---|---|
In diethyl ether at 20℃; Inert atmosphere; Molecular sieve; Darkness; | 100% |
Conditions | Yield |
---|---|
With piperidine; acetic acid In dichloromethane at 0 - 20℃; Michael Addition; Molecular sieve; | 100% |
With L-Lysine hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 3h; Knoevenagel Condensation; | 98.3% |
With cross-linked polystyrene-titanium tetrachloride complex In neat (no solvent) at 60℃; for 2h; Knoevenagel Condensation; | 98% |
Conditions | Yield |
---|---|
With copper(II) bis(trifluoromethanesulfonate) In water at 20℃; for 0.0166667h; | 100% |
In water at 20℃; for 2h; | 93% |
In dichloromethane Inert atmosphere; Molecular sieve; | 81% |
Conditions | Yield |
---|---|
With 1-butyl-1,4-diazabicyclo[2.2.2]octanylium hydrotetrafluoroborate In water at 20℃; for 0.0166667h; Knoevenagel condensation; | 100% |
With 1,4-diaza-bicyclo[2.2.2]octane In water at 20℃; for 0.0166667h; Knoevenagel Condensation; Green chemistry; | 100% |
With hydroquinone; p-benzoquinone In water at 20℃; for 3h; Reagent/catalyst; Knoevenagel Condensation; Inert atmosphere; Sealed tube; | 100% |
Conditions | Yield |
---|---|
With Yb(III)-coordinated adamantane-based porous polymer In methanol at 20℃; for 12h; Catalytic behavior; Reagent/catalyst; | 100% |
indium(III) triflate In dichloromethane at 20℃; for 0.0833333h; | 99% |
With cerium triflate In methanol at 20℃; for 0.0333333h; | 99% |
Conditions | Yield |
---|---|
With hydrogen In ethanol at 60℃; under 15001.5 Torr; for 4h; Catalytic behavior; Reagent/catalyst; Temperature; Solvent; Pressure; Autoclave; Green chemistry; | 100% |
With hydrogen In butan-1-ol at 80℃; under 30003 Torr; for 5h; Catalytic behavior; Temperature; Reagent/catalyst; | 99% |
With hydrogen In isopropyl alcohol at 179.84℃; under 22502.3 Torr; for 1.25h; Reagent/catalyst; | 99% |
Conditions | Yield |
---|---|
With hydrogen under 2250.23 Torr; for 15h; | 100% |
With hydrogen at 200℃; under 760.051 Torr; | 95.5% |
With hydrogen at 120℃; under 760.051 Torr; for 24h; Catalytic behavior; Reagent/catalyst; Temperature; | 94.5% |
Conditions | Yield |
---|---|
With Pt(3)Co(3)/C; hydrogen In water at 35℃; under 750.075 Torr; for 10h; Reagent/catalyst; Pressure; Temperature; Solvent; Concentration; | 100% |
With HRO/TiO2; hydrogen In water at 150℃; under 15001.5 Torr; for 3h; | 100% |
With hydrogen In isopropyl alcohol at 179.84℃; under 22502.3 Torr; for 1.25h; Reagent/catalyst; | 100% |
furfural
5-hydroxy-2-(5H)-furanone
Conditions | Yield |
---|---|
With methanol; oxygen Irradiation; | 100% |
With oxygen; methylene blue In methanol at -78 - 20℃; for 23h; Irradiation; | 98% |
With oxygen; Rose Bengal lactone In methanol at 20℃; for 24h; Photolysis; | 93% |
Conditions | Yield |
---|---|
With ammonia; hydrogen In tetrahydrofuran at 80℃; for 2h; Autoclave; | 100% |
With ammonia; hydrogen In methanol at 30℃; for 24h; Autoclave; | 91% |
With ammonium hydroxide; Ni6AlO(z); hydrogen at 100℃; under 3000.3 Torr; for 5h; Autoclave; | 90% |
Conditions | Yield |
---|---|
With pyridine; hydroxylamine hydrochloride In ethanol | 100% |
With hydroxylamine hydrochloride In ethanol; water for 0.166667h; Microwave irradiation; | 89% |
With N-hydroxyphthalimide In water at 90℃; for 3h; Sealed tube; | 89% |
furfural
1,2-di-furan-2-yl-ethane-1,2-diol
Conditions | Yield |
---|---|
With tris(2,2’-bipyridine)ruthenium(II); ascorbate In water for 3h; pH=12.7; Irradiation; | 100% |
With ammonium chloride; magnesium Ambient temperature; | 92% |
With triethylammonium formate; magnesium In methanol; water at 25℃; for 0.333333h; | 74% |
Conditions | Yield |
---|---|
With lithium tetrafluoroborate at 0℃; for 5h; | 100% |
With amberlyst-15 In acetonitrile for 1h; | 99.92% |
With dimethylbromosulphonium bromide at 20℃; for 0.0833333h; | 98% |
furfural
diethoxyphosphoryl-acetic acid ethyl ester
ethyl (E)-3-(2-furyl)prop-2-enoate
Conditions | Yield |
---|---|
With potassium carbonate In neat (no solvent) Mechanism; var. other bases, effect of water; | 100% |
With water; barium dihydroxide In 1,4-dioxane at 70℃; for 0.416667h; | 100% |
With water; barium dihydroxide In 1,4-dioxane at 70℃; for 0.416667h; Product distribution; other catalyst, other solvents, influence of water; | 100% |
Conditions | Yield |
---|---|
With (R)-oxynitrilase (almond meal) In di-isopropyl ether at 4℃; for 48h; | 100% |
With almond meal ((R)-oxynitrilase) In di-isopropyl ether at 4 - 30℃; | 100% |
With almond meal In di-isopropyl ether at 15℃; | 100% |
furfural
trimethylsilyl cyanide
2-(2-furyl)-2-(trimethylsilyloxy)acetonitrile
Conditions | Yield |
---|---|
With Eu2(benzene-1,2,3,4,5,6-hexacarboxylate)(H2O)3 In acetonitrile at 20 - 100℃; for 1h; | 100% |
With 1-methoxy-2-methyl-1-(trimethylsiloxy)propene at 19℃; for 10h; | 99% |
With potassium phtalimide at 20℃; for 1.16667h; solvent-free; | 99% |
Conditions | Yield |
---|---|
With water; barium dihydroxide In 1,4-dioxane at 70℃; for 0.666667h; | 100% |
Stage #1: diethyl 1-cyanomethylphosphonate With sodium hydride In tetrahydrofuran at 20℃; for 1h; Inert atmosphere; Stage #2: furfural In tetrahydrofuran at 28℃; | |
Stage #1: diethyl 1-cyanomethylphosphonate With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Stage #2: furfural In tetrahydrofuran; mineral oil at 0 - 25℃; for 2h; |
furfural
1-(Hydroxyaminomethyl)-1-cyclohexanol
N-Furfuryliden-(1-hydroxycyclohexyl)methanamin-N-oxid
Conditions | Yield |
---|---|
In ethanol Ambient temperature; | 100% |
furfural
(R)-Phenylglycinol
(R)-2-{[1-Furan-2-yl-meth-(E)-ylidene]-amino}-2-phenyl-ethanol
Conditions | Yield |
---|---|
With magnesium sulfate In dichloromethane at 20℃; for 12h; | 100% |
In benzene Heating; | 88% |
In benzene Heating; | 85% |
With magnesium sulfate In dichloromethane | |
In toluene Condensation; Heating; |
Conditions | Yield |
---|---|
With potassium hydroxide In neat (no solvent) Mechanism; var. other bases, effect of water; | 100% |
With potassium hydroxide In water; acetonitrile | 98% |
With potassium hydroxide; water In acetonitrile at 40℃; for 0.833333h; Product distribution; | 93% |
Conditions | Yield |
---|---|
In tetrahydrofuran at 0℃; for 1h; Inert atmosphere; | 100% |
In tetrahydrofuran at 0 - 20℃; Inert atmosphere; | 98% |
In tetrahydrofuran at 0 - 20℃; Inert atmosphere; | 92% |
furfural
sodium cyanide
chloroformic acid ethyl ester
carbonic acid, cyano(2-furyl)methyl ethyl ester
Conditions | Yield |
---|---|
With tetrabutyl-ammonium chloride In dichloromethane; water Heating; | 100% |
Conditions | Yield |
---|---|
In methanol at 20℃; for 24h; | 100% |
for 2h; Yield given; | |
With magnesium sulfate In ethanol at 20℃; |
furfural
4-penten-1-ylmagnesium bromide
(+/-)-1-(furan-2-yl)hex-5-en-1-ol
Conditions | Yield |
---|---|
In tetrahydrofuran at 0℃; | 100% |
In tetrahydrofuran at 0 - 20℃; for 2h; Inert atmosphere; | 86% |
In tetrahydrofuran at 0℃; | 73% |
In 1832, the German chemist Johann Wolfgang D?bereiner ,first isolated furfural ,he formed a very small quantity of it as a byproduct of formic acid synthesis.
In 1840, the Scottish chemist John Stenhouse found that the same chemical could be produced by distilling a wide variety of crop materials, including bran, corn, oats, and sawdust, with aqueous sulfuric acid, and he determined that this chemical had an empirical formula of C5H4O2.
In 1901, the German chemist Carl Harries deduced furfural's structure.
NTP Carcinogenesis Studies (gavage); Clear Evidence: mouse NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NTP-TR-382,90, . , Some Evidence: rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NTP-TR-382 ,1990. . EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.
OSHA PEL: TWA 2 ppm (skin)
ACGIH TLV: TWA 2 ppm (skin); Animal Carcinogen: BEI: 200 mg/g creatinine of total furoic acid in urine at end of shift
DFG MAK: Confirmed Animal Carcinogen with Unknown Relevance to Humans
DOT Classification: 3; Label: Flammable Liquid
For occupational chemical analysis use OSHA: #ID-72 or NIOSH: Furfural, 2529.
Furfural is an heterocyclic aldehyde, with the ring structure shown at right. Its chemical formula is OC4H3CHO. It is a colorless oily liquid with the odor of almonds, but upon exposure to air samples quickly become yellow. With the CAS NO. 98-01-1, Furfural dissolves readily in most polar organic solvents, but is only slightly soluble in either water or alkanes. When heated above 250 °C, furfural decomposes into furan and carbon monoxide, sometimes explosively.
Physical properties Furfural are:
(1)ACD/LogP: 0.731; (2)ACD/LogD (pH 5.5): 0.73; (3)ACD/LogD (pH 7.4): 0.73; (4)ACD/BCF (pH 5.5): 2.12; (5)ACD/BCF (pH 7.4): 2.12; (6)ACD/KOC (pH 5.5): 59.53; (7)ACD/KOC (pH 7.4): 59.53; (8)#H bond acceptors:2; (9)#Freely Rotating Bonds: 1; (10)Index of Refraction: 1.515; (11)Molar Refractivity: 25.305 cm3; (12)Molar Volume: 83.894 cm3; (13)Polarizability: 10.032 10-24cm3; (14)Surface Tension: 36.5740013122559 dyne/cm; (15)Density: 1.145 g/cm3; (16)Flash Point: 58.333 °C; (17)Enthalpy of Vaporization: 39.837 kJ/mol; (18)Boiling Point: 161.799 °C at 760 mmHg; (19)Vapour Pressure: 2.23399996757507 mmHg at 25°C
Preparation of Furfural:
Many plant materials contain the polysaccharide hemicellulose, a polymer of sugars containing five carbon atoms each. When heated with sulfuric acid, hemicellulose undergoes hydrolysis to yield these sugars, principally xylose. Under the same conditions of heat and acid, xylose and other five carbon sugars undergo dehydration, losing three water molecules to become furfural:
C5H10O5 → C5H4O2 + 3 H2O
Uses of Furfural:
Furfural is used as a solvent in petrochemical refining to extract dienes ( used to make synthetic rubber) from other hydrocarbons . Furfural also can be used either by themselves or in together with phenol, acetone, or urea to make solid resins. It is also used as a chemical intermediate in the production of the solvents furan and tetrahydrofuran.
Safety information of Furfural:
When you are using this chemical, please be cautious about it as the following:(1)In case of contact with eyes, rinse immediately with plenty of water and seek medical advice; (2)Wear suitable protective clothing, gloves and eye/face protection; (3)In case of accident or if you feel unwell, seek medical advice immediately (show label where possible); (4)Keep locked up and out of the reach of children;
You can still convert the following datas into molecular structure:
(1)InChI=1S/C5H4O2/c6-4-5-2-1-3-7-5/h1-4H;
(2)InChIKey=HYBBIBNJHNGZAN-UHFFFAOYSA-N;
(3)Smilesc1(ccco1)C=O;
The toxiciy data of Furfural is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LC50 | inhalation | 370ppm/6H (370ppm) | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 279, 1969. | |
dog | LD50 | intravenous | 250mg/kg (250mg/kg) | Food and Cosmetics Toxicology. Vol. 16, Pg. 759, 1978. | |
dog | LD50 | oral | 950mg/kg (950mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: ATAXIA | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 279, 1969. |
dog | LD50 | subcutaneous | 214mg/kg (214mg/kg) | Food and Cosmetics Toxicology. Vol. 16, Pg. 759, 1978. | |
frog | LDLo | parenteral | 23gm/kg (23000mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 21, Pg. 65, 1923. | |
guinea pig | LD50 | oral | 541mg/kg (541mg/kg) | KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" BLOOD: HEMORRHAGE | Hygiene and Sanitation Vol. 32(5), Pg. 158, 1967. |
guinea pig | LDLo | subcutaneous | 100mg/kg (100mg/kg) | Food and Cosmetics Toxicology. Vol. 16, Pg. 759, 1978. | |
human | TCLo | inhalation | 310ug/m3 (.31mg/m3) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 26(6), Pg. 3, 1961. | |
mouse | LCLo | inhalation | 370ppm/6H (370ppm) | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 279, 1969. | |
mouse | LD50 | intraperitoneal | 102mg/kg (102mg/kg) | Food and Cosmetics Toxicology. Vol. 16, Pg. 759, 1978. | |
mouse | LD50 | intravenous | 152mg/kg (152mg/kg) | Food and Cosmetics Toxicology. Vol. 16, Pg. 759, 1978. | |
mouse | LD50 | oral | 400mg/kg (400mg/kg) | Biochemical Journal. Vol. 34, Pg. 1196, 1940. | |
mouse | LD50 | subcutaneous | 119mg/kg (119mg/kg) | Food and Cosmetics Toxicology. Vol. 16, Pg. 759, 1978. | |
rabbit | LD50 | intramuscular | 78mg/kg (78mg/kg) | Food and Cosmetics Toxicology. Vol. 16, Pg. 759, 1978. | |
rabbit | LDLo | oral | 800mg/kg (800mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Journal of Pharmacology and Experimental Therapeutics. Vol. 21, Pg. 65, 1923. |
rabbit | LDLo | skin | 620mg/kg (620mg/kg) | Food and Cosmetics Toxicology. Vol. 16, Pg. 759, 1978. | |
rabbit | LDLo | subcutaneous | 500mg/kg (500mg/kg) | Hygiene and Sanitation Vol. 32(5), Pg. 158, 1967. | |
rat | LC50 | inhalation | 175ppm/6H (175ppm) | American Industrial Hygiene Association Journal. Vol. 50, Pg. A359, 1989. | |
rat | LC50 | inhalation | 175ppm/6H (175ppm) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | American Industrial Hygiene Association Journal. Vol. 50, Pg. A359, 1989. |
rat | LD50 | intraperitoneal | 20mg/kg (20mg/kg) | Food and Cosmetics Toxicology. Vol. 16, Pg. 759, 1978. | |
rat | LD50 | oral | 65mg/kg (65mg/kg) | Bromatologia i Chemia Toksykologiczna. Vol. 13, Pg. 371, 1980. | |
rat | LD50 | subcutaneous | 148mg/kg (148mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 279, 1969. |
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