Isoleucine supplier | CasNO.73-32-5

Name
L-Isoleucine
EINECS 200-798-2
CAS No. 73-32-5
Article Data209
CAS DataBase
Density 1.036 g/cm³
Solubility 41.2 g/L (50 °C) in water
Melting Point 288 °C (dec.)(lit.)
Formula C₆H₁₃NO₂
Boiling Point 225.772 °C at 760 mmHg
Molecular Weight 131.175
Flash Point 90.344 °C
Transport Information
Appearance White crystalline powder
Safety 24/25-36-22
Risk Codes 40
Molecular Structure
Hazard Symbols Xn
Synonyms (2S,3S)-Ile;L-Isoieucine;L-Isoleucine;Z-(s,S)-isoleucine;H-L-ILE-OH;H-lle-OH;L-Ile (2S,3S);N-methyl Ile;H-ILE-OH;L-Isoleusine;L(+)-Isoleucin;(2S,3S)-2-Amino-3-methylpentanoicacid;ILE;(S)-isoleucin;Isoleucin;查看更多英文别名收起
PSA 63.32000
LogP 1.14470

Synthetic route

: Poc-Ile-OH

: 73-32-5
L-isoleucine

Conditions

Conditions	Yield
With resin bound tetrathiomolybdate In methanol at 28℃; for 1.5h; ultrasonic bath;	100%

: 71989-23-6
Fmoc-Ile-OH

: 73-32-5
L-isoleucine

Conditions

Conditions	Yield
With potassium fluoride; 18-crown-6 ether In N,N-dimethyl-formamide for 9h; Ambient temperature;	98%

: 13139-16-7
N-(tert-butyloxycarbonyl)-L-isoleucine

: 73-32-5
L-isoleucine

Conditions

Conditions	Yield
With tetradecyl(trihexyl)phosphonium bistriflamide; trifluoroacetic acid at 130℃; for 0.166667h; Ionic liquid;	98%
With trifluoroacetic acid at 20℃; for 0.25h;

Boc-Ile-Merrifield resin: Boc-Ile-Merrifield resin

: 73-32-5
L-isoleucine

Conditions

Conditions	Yield
With dimethyl ether-poly(hydrogen fluoride) at 0℃; for 1h;	93%

: (2S,3S)-3-Methyl-2-[2-methyl-2-(2-nitro-phenyl)-propionylamino]-pentanoic acid benzyl ester

A: 19155-24-9
3,3-dimethyloxindole

B: 32353-29-0
1,3-dihydro-3,3-dimethyl-1-hydroxy-H-indol-2-one

C: 73-32-5
L-isoleucine

Conditions

Conditions	Yield
With hydrogen; acetic acid; palladium on activated charcoal In methanol for 0.5h;	A n/a B n/a C 85%

...Expand

: 5860-63-9, 45895-88-3, 45895-89-4, 45895-90-7, 51829-75-5
(S)-4-((S)-sec-butyl)oxazolidine-2,5-dione

: 56-40-6
L-Glycin

A: 73-32-5
L-isoleucine

B: 868-28-0
isoleucyl‐glycine

C: 462-60-2
N-carbamoylglycine

D oligomers of ile: oligomers of ile

Conditions

Conditions	Yield
With water; potassium hydroxide; potassium borate buffer at 3℃; Product distribution; effect of use of various amino acid and NCA with various concentrations; effect of use various temp.; extent of hydrolysis;	A n/a B 83.9% C n/a D n/a

...Expand

: C6H13NO2*H3N*ClH

: 73-32-5
L-isoleucine

Conditions

Conditions	Yield
With ruthenium nanoparticles dispersed in a polyvinylpyrrolidone matrix; amberlyst A-21 In methanol; dichloromethane	75%

: 26117-19-1
(2S,3S)-3-methyl-2-ureidopentanoic acid

: 73-32-5
L-isoleucine

Conditions

Conditions	Yield
With NH4Cl-NH4OH buffer pH 8.5; nickel dichloride at 60℃; for 24h; N-carbamyl-L-amino acid aminohydrolase;	55%
With sodium phosphate buffer; N-carmamyl-L-amino acid aminohydrolase of Pseudomonas sp. strain NS671; water; manganese(II) at 30℃; for 0.5h; Product distribution;	17.1 mmol
With Tris-HCl buffer; N-carbamoyl-L-amino acid hydrolase; iron(II) sulfate at 30℃; for 2h;

: DL-α-keto-β-methyl-n-valerate

A: 319-78-8, 443-79-8, 1509-34-8, 1509-35-9, 3107-04-8, 7004-09-3, 73-32-5
isoleucine

B: 73-32-5
L-isoleucine

Conditions

Conditions	Yield
With ammonium formate; tris hydrochloride; nicotinamide adenine dinucleotide; formate dehydrogenase; phenylalanine dehydrogenase In water at 30℃; for 24h;	A 50% B 48%

: (2RS,3S)-2-amino-3-methylpentanoic acid

A: 73-32-5
L-isoleucine

B: 1509-35-9
D-alloisoleucine

Conditions

Conditions	Yield
With C13H15NO5V(1-)*C16H36N(1+) In ethanol; water	A n/a B 50%
With C13H15NO5V(1-)*C16H36N(1+) In ethanol; water	A 24% B n/a

: C7H16N2O*H(1+)

: 73-32-5
L-isoleucine

Conditions

Conditions	Yield
With hydrogenchloride; Dowex 50W In toluene at 110℃;	34%

: 50-99-7
D-glucose

: 73-32-5
L-isoleucine

Conditions

Conditions	Yield
With Escherichia coli TVD5 at 37℃; for 24h; biotransformation; Microbiological reaction;	25.5%

: 24424-99-5
di-tert-butyl dicarbonate

: 77120-55-9
N-chloro-(2S,3S)-amino-3-methyl-pentanoic acid ethyl ester

A: 73-32-5
L-isoleucine

B: 411225-57-5
(2S,3S)-1-tert-butyl 2-ethyl 3-methyl-pyrrolidine-1,2-dicarboxylate

Conditions

Conditions	Yield
Stage #1: N-chloro-(2S,3S)-amino-3-methyl-pentanoic acid ethyl ester With sulfuric acid at 3 - 9℃; for 3h; UV-irradiation; Stage #2: di-tert-butyl dicarbonate With potassium carbonate In 1,4-dioxane; water at 0 - 20℃; Further stages.;	A n/a B 25%

...Expand

: 74-90-8
hydrogen cyanide

: 1730-97-8
(S)-2-methylbutyraldehyde

A: 73-32-5
L-isoleucine

B: 1509-35-9
D-alloisoleucine

Conditions

Conditions	Yield
With ammonia durch Verseifung des entstandenen Aminonitrils mit Salzsaeure;

...Expand

: 319-78-8, 443-79-8, 1509-34-8, 1509-35-9, 3107-04-8, 7004-09-3, 73-32-5
isoleucine

: 73-32-5
L-isoleucine

Conditions

Conditions	Yield
durch gaerende Hefe;
With D-amino acid oxide ase-substances Durch selektiven Abbau;

: 73-32-5, 319-78-8, 443-79-8, 1509-34-8, 1509-35-9, 3107-04-8, 7004-09-3
DL-isoleucine

: 73-32-5
L-isoleucine

Conditions

Conditions	Yield
fuehrt man dieses in Formyl-dl-isoleucin ueber und zerlegt letzteres in konz. alkoh. Loesung durch Brucin in die aktiven Komponenten;

: 4101-35-3, 89810-44-6
N-formyl-L-isoleucine

: 73-32-5
L-isoleucine

Conditions

Conditions	Yield
With hydrogen bromide

: 1115-24-8, 67253-30-9
N-chloroacetyl-isoleucine

: 73-32-5
L-isoleucine

Conditions

Conditions	Yield
With acylase-I-substances Hydrolysis;

: 1115-24-8, 67253-30-9
N-chloroacetyl-DL-isoleucine

A: 73-32-5
L-isoleucine

B: 907582-60-9
N-chloroacetyl-D-isoleucine

Conditions

Conditions	Yield
bei der Einwirkung von Acylase-I-Praeparaten aus Schweinenieren;

: N-isobutyryl-L-isoleucine anilide

: 73-32-5
L-isoleucine

Conditions

Conditions	Yield
With hydrogenchloride

: 2280-44-6
D-Glucose

A: 73-32-5
L-isoleucine

B: 56-86-0
L-glutamic acid

C: 657-27-2, 10098-89-2
L-Lysine hydrochloride

D: 60-18-4
L-tyrosine

Conditions

Conditions	Yield
at 30℃; for 72h; Brevibacterium flavum, mutant strain AH-198, soybean-meal hydrolysate, (NH4)2SO4; Yield given. Further byproducts given. Yields of byproduct given;

...Expand

: 73-32-5, 319-78-8, 443-79-8, 1509-34-8, 1509-35-9, 3107-04-8, 7004-09-3
DL-isoleucine

A: 73-32-5
L-isoleucine

B: 319-78-8
D-Isoleucine

: 2627-86-3
(S)-1-phenyl-ethylamine

: 2-methyl-4-sec-butylidene-5-oxazolone

A: 1509-34-8
D-allo-isoleucine

B: 73-32-5
L-isoleucine

C: 319-78-8
D-Isoleucine

D: 1509-35-9
D-alloisoleucine

Conditions

Conditions	Yield
Product distribution; Rate constant; multistep reaction;

...Expand

: 129505-17-5
(2S,3S)-2-Amino-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-3-methyl-pentan-1-one

: 73-32-5
L-isoleucine

Conditions

Conditions	Yield
With lithium hydroxide; ion exchange 1.) THF; Yield given. Multistep reaction;

: 201230-82-2
carbon monoxide

A: 56-45-1
L-serin

B: 72-19-5
L-threonine

C: 73-32-5
L-isoleucine

D: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
With sodium molybdate; ammonium iron (II) sulfate; water; sodium carbonate; ammonium chloride; calcium chloride; magnesium chloride; zinc(II) chloride for 5h; Ambient temperature; Irradiation; pH=7.0; Further byproducts given;

...Expand

: 80995-96-6
(2S,3S)-2-{[1-(3-Hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-yl)-meth-(Z)-ylidene]-amino}-3-methyl-pentanoic acid

A: 73-32-5
L-isoleucine

B: 54-47-7
pyridoxal 5'-phosphate

Conditions

Conditions	Yield
In water at 25℃; Equilibrium constant; Mechanism; over a wide pH range;
With phosphate buffer; Carbonate buffer at 25℃; Equilibrium constant; var. pH;

: 106749-12-6
(2S,3R)-2-Azido-3-methyl-pentanoic acid (1R,2S,4S)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

A: 1509-34-8
D-allo-isoleucine

B: 73-32-5
L-isoleucine

C: 319-78-8
D-Isoleucine

D: 1509-35-9
D-alloisoleucine

Conditions

Conditions	Yield
With titanium tetrakis(benzyl alkoxide); hydrogen; Pd-BaSO4 1.) benzyl alcohol, 130 gradC 2.) EtOH, EtOAc, 1 atm, r.t.; Yield given. Multistep reaction. Title compound not separated from byproducts;

...Expand

: 27395-04-6, 114284-90-1, 114284-91-2
N-(S)-2-methylbutylformamide

A: 73-32-5
L-isoleucine

B: 1509-35-9
D-alloisoleucine

Conditions

Conditions	Yield
With hydrogenchloride; Dowex 50(H+) at 100 - 110℃; for 24h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

: 114284-92-3, 114284-93-4
N-((S)-1-Cyano-2-methyl-butyl)-acetamide

A: 73-32-5
L-isoleucine

B: 1509-35-9
D-alloisoleucine

Conditions

Conditions	Yield
With hydrogenchloride; Dowex 50(H+) at 100 - 110℃; for 24h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

: ((S)-1-Cyano-2-methyl-butyl)-carbamic acid methyl ester

A: 73-32-5
L-isoleucine

B: 1509-35-9
D-alloisoleucine

Conditions

Conditions	Yield
With hydrogenchloride; Dowex 50(H+) at 100 - 110℃; for 24h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

: 67-56-1
methanol

: 73-32-5
L-isoleucine

: 2577-46-0
L-isoleucine methyl ester

Conditions

Conditions	Yield
Stage #1: methanol With thionyl chloride at -15 - 0℃; for 1h; Stage #2: L-isoleucine for 3h; Reflux;	100%
With hydrogenchloride	96%
With thionyl chloride at 0℃; for 12h; Reflux;	95%

: 64-17-5
ethanol

: 73-32-5
L-isoleucine

: 921-74-4
L-isoleucine ethyl ester

Conditions

Conditions	Yield
With thionyl chloride for 38h; Heating;	100%
With thionyl chloride	100%
With thionyl chloride for 10h; Heating;	65%

: 73-32-5
L-isoleucine

: 24424-99-5
di-tert-butyl dicarbonate

: 13139-16-7
N-(tert-butyloxycarbonyl)-L-isoleucine

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane; water at 20℃; for 24h;	100%
Stage #1: L-isoleucine With sodium hydroxide In 1,4-dioxane; water at 0℃; Stage #2: di-tert-butyl dicarbonate In 1,4-dioxane; water at 0 - 20℃;	100%
With sodium hydroxide In 1,4-dioxane; water at 0℃;	100%

: 85-44-9
phthalic anhydride

: 73-32-5
L-isoleucine

: 29588-88-3
N-phthaloyl-L-isoleucine

Conditions

Conditions	Yield
at 135℃;	100%
at 140℃; for 0.166667h;	99%
With triethylamine Inert atmosphere;	98%

: 73-32-5
L-isoleucine

: 501-53-1
benzyl chloroformate

: 3160-59-6
N-Cbz-L-Isoleucine

Conditions

Conditions	Yield
With sodium hydroxide In water at 0 - 20℃;	100%
With sodium hydroxide In 1,4-dioxane; toluene at 0℃;	97%
With water; sodium hydrogencarbonate; sodium carbonate In acetone at 15 - 20℃; pH=8 - 10;	95%

: 73-32-5
L-isoleucine

: 81-30-1
1,4,5,8-naphthalenetetracarboxylic dianhydride

: 1313710-81-4
2,2'-(1,3,6,8-tetraoxo-1,3,6,8-tetrahydrobenzo[lmn][3,8]phenanthroline-2,7-diyl)bis(3-methylpentanoic acid)

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 110℃; for 24h;	100%
With acetic acid for 36h; Reflux;	89%

: 59985-82-9
5-phenylisoxazole-3-carbaldehyde

: 73-32-5
L-isoleucine

: C16H17N2O3(1-)*Li(1+)

Conditions

Conditions	Yield
With lithium hydride In methanol Reflux;	100%

: 59985-82-9
5-phenylisoxazole-3-carbaldehyde

: 73-32-5
L-isoleucine

: Na(1+)*C16H17N2O3(1-)

Conditions

Conditions	Yield
With sodium methylate In methanol Reflux;	100%

: 59985-82-9
5-phenylisoxazole-3-carbaldehyde

: 73-32-5
L-isoleucine

: Cs(1+)*C16H17N2O3(1-)

Conditions

Conditions	Yield
With caesium carbonate In methanol Reflux;	100%

: 59985-82-9
5-phenylisoxazole-3-carbaldehyde

: 73-32-5
L-isoleucine

: Ca(2+)*2C16H17N2O3(1-)

Conditions

Conditions	Yield
With calcium hydride In methanol Reflux;	100%

: 73-32-5
L-isoleucine

: 640292-02-0
5-(4-methylphenyl)-1,2-oxazole-3-carbaldehyde

: C17H19N2O3(1-)*Li(1+)

Conditions

Conditions	Yield
With lithium hydride In methanol Reflux;	100%

: 73-32-5
L-isoleucine

: 640292-02-0
5-(4-methylphenyl)-1,2-oxazole-3-carbaldehyde

: C17H19N2O3(1-)*Na(1+)

Conditions

Conditions	Yield
With sodium methylate In methanol Reflux;	100%

: 73-32-5
L-isoleucine

: 640292-02-0
5-(4-methylphenyl)-1,2-oxazole-3-carbaldehyde

: C17H19N2O3(1-)*Cs(1+)

Conditions

Conditions	Yield
With caesium carbonate In methanol Reflux;	100%

: 73-32-5
L-isoleucine

: 640292-02-0
5-(4-methylphenyl)-1,2-oxazole-3-carbaldehyde

: 2C17H19N2O3(1-)*Ca(2+)

Conditions

Conditions	Yield
With calcium hydride In methanol Reflux;	100%

: 73-32-5
L-isoleucine

: 32315-10-9
bis(trichloromethyl) carbonate

: 5860-63-9, 45895-88-3, 45895-89-4, 45895-90-7, 51829-75-5
(S)-4-((S)-sec-butyl)oxazolidine-2,5-dione

Conditions

Conditions	Yield
In tetrahydrofuran at 50℃; for 4.5h; Inert atmosphere;	100%

: 59-67-6
nicotinic acid

: 73-32-5
L-isoleucine

: (1S,2S)-1-carboxy-2-methylbutan-1-aminium nicotinate

Conditions

Conditions	Yield
In water for 0.166667h; pH=Ca. 2.3 - 3.3; Cooling with ice;	100%

: 67-56-1
methanol

: 73-32-5
L-isoleucine

: 18598-74-8
methyl L-isoleucinate hydrochloride

Conditions

Conditions	Yield
With acetyl chloride for 18h; Reflux;	99%
With hydrogenchloride Ambient temperature;	98%
Stage #1: methanol With thionyl chloride at 0℃; for 0.5h; Stage #2: L-isoleucine In methanol at 0℃;	97.5%

: 73-32-5
L-isoleucine

: 488-15-3, 59653-35-9, 70748-47-9, 86540-81-0, 86630-77-5, 51576-04-6
(2S,3S)-2-Hydroxy-3-methylpentanoic acid

Conditions

Conditions	Yield
With sulfuric acid; sodium nitrite In water at 0 - 20℃;	99%
With sulfuric acid; sodium nitrite at 0 - 20℃; for 18h;	92%
With sulfuric acid; water; sodium nitrite at 60℃; Flow reactor;	92%

: 73-32-5
L-isoleucine

: 159407-40-6
(2S,3S)-2-azido-3-methylpentanoic acid

Conditions

Conditions	Yield
With sodium azide; copper(ll) sulfate pentahydrate; trifluoromethylsulfonic anhydride; potassium carbonate In methanol; dichloromethane; water at 0 - 20℃; for 16h;	99%
With sodium azide; trifluoromethylsulfonic anhydride; copper sulfate pentahydrate; potassium carbonate In dichloromethane; water at 20℃; for 16h;	99%
With sodium azide; copper(ll) sulfate pentahydrate; trifluoromethylsulfonic anhydride; potassium carbonate In dichloromethane; water at 0 - 20℃; for 16h;	99%

: 73-32-5
L-isoleucine

: 192999-60-3
4-(phenylacetoxy)benzyl-L-phenylalanine

: 4-(phenylacetoxy)benzyl-Phe-Ile-OH

Conditions

Conditions	Yield
With HEPES-buffer; calcium chloride; thermolysin In ethyl acetate at 40℃; for 48h; pH=6.5;	99%

: 73-32-5
L-isoleucine

: 2483-49-0
tert-butyloxycarbonyl-L-alanine p-nitrophenyl ester

: 70396-21-3
Boc-Ala-Ile-OH

Conditions

Conditions	Yield
Stage #1: L-isoleucine With calcium hydroxide In water at 20℃; Stage #2: tert-butyloxycarbonyl-L-alanine p-nitrophenyl ester In N,N-dimethyl-formamide at 25℃; for 24h;	99%

: 61-90-5
L-leucine

: 73-32-5
L-isoleucine

: 141-82-2
malonic acid

: 98137-41-8
L-valinal

Fmoc-Asn(PG)-OH: Fmoc-Asn(PG)-OH

Fmoc-Ser(PG)-OH: Fmoc-Ser(PG)-OH

Fmoc-Lys(PG)-OH: Fmoc-Lys(PG)-OH

Fmoc-Asp(PG)-OH: Fmoc-Asp(PG)-OH

: 1571091-79-6
(Ac)-NSLKIDNLDV-CONH2

Conditions

Conditions	Yield
Stage #1: L-valinal With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide Stage #2: With piperidine for 0.333333h; Microwave irradiation; Stage #3: L-leucine; L-isoleucine; malonic acid; Fmoc-Asn(PG)-OH; Fmoc-Ser(PG)-OH; Fmoc-Lys(PG)-OH; Fmoc-Asp(PG)-OH Further stages;	99%

...Expand

: 73-32-5
L-isoleucine

: 3855-45-6
triflic azide

: 159407-40-6
(2S,3S)-2-azido-3-methylpentanoic acid

Conditions

Conditions	Yield
With copper(ll) sulfate pentahydrate; potassium carbonate In methanol; water at 20℃; for 16h;	99%
With copper(ll) sulfate pentahydrate; potassium carbonate In methanol; dichloromethane; water at 20℃;	75%

: 872-85-5
pyridine-4-carbaldehyde

: 73-32-5
L-isoleucine

: C12H18N2O2

Conditions

Conditions	Yield
Stage #1: pyridine-4-carbaldehyde; L-isoleucine With sodium carbonate In water at 60℃; for 3h; Stage #2: With sodium tetrahydroborate In water at 0℃;	98.15%

: 73-32-5
L-isoleucine

: 98-59-9
p-toluenesulfonyl chloride

: 34235-81-9
3-methyl-2-{[(4-methylphenyl)sulfonyl]amino}pentanoic acid

Conditions

Conditions	Yield
In water at 110℃; for 0.0833333h; Microwave irradiation; Green chemistry; chemoselective reaction;	98%
With sodium carbonate In water for 5h;	95.74%
With sodium carbonate In water for 4h;	95.74%

: 73-32-5
L-isoleucine

: 448211-74-3
4-(phenylacetoxy)benzyl-L-methionine

: 4-(phenylacetoxy)benzyl-Met-Ile-OH

Conditions

Conditions	Yield
With HEPES-buffer; calcium chloride; thermolysin In ethyl acetate at 40℃; for 24h; pH=6.5;	98%

: 73-32-5
L-isoleucine

: 25570-03-0
(+)-(S)-2-methylbutane nitrile

Conditions

Conditions	Yield
With sodium hydroxide; trichloroisocyanuric acid at 25℃; for 0.5h;	98%
With trichloroisocyanuric acid; sodium hydrogencarbonate In water at 5 - 15℃; for 3.25h;	93.2%
With ammonium bromide In methanol; water Electrochemical reaction;	86%

: 3,5-dioxopiperidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

: 73-32-5
L-isoleucine

: 811450-60-9
5-(1-carboxy-2-methyl-butylamino)-3-oxo-3,6-dihydro-2H-pyridine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Conditions

Conditions	Yield
In methanol at 60℃;	98%

Isoleucine Consensus Reports

Reported in EPA TSCA Inventory.

Isoleucine Specification

Isoleucine is an α-amino acid with the chemical formula HO₂CCH(NH₂)CH(CH₃)CH₂CH₃. With the CAS NO.73-32-5, it also called (2S,3S)-2-Amino-3-methylpentansαure; (2s,3s)-alpha-amino-beta-merthylvalericacid; (2s,3s)-alpha-amino-beta-methyl-n-valericacid; (s-(r*,r*))-2-amino-3-methylpentanoicaci; (s-(r*,r*))-2-amino-3-methylpentanoicacid; (S,S)-2-amino-3-methyl-pentanoicacid; (s,s)-isoleucine; [S-(R*,R*)]-2-Amino-3-methylpentanoic acid. And it is a white crystals or crystalline solid. Isoleucine can be used in biochemical research, and in medicine used for nutritional supplements.

Physical properties about Isoleucine are: (1)ACD/LogP: 0.799; (2)ACD/LogD (pH 5.5): -1.70; (3)ACD/LogD (pH 7.4): -1.70; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 1.00; (7)ACD/KOC (pH 7.4): 1.00; (8)#H bond acceptors: 3; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 4; (11)Index of Refraction: 1.463; (12)Molar Refractivity: 34.863 cm³; (13)Molar Volume: 126.632 cm³; (14)Polarizability: 13.821 10-24cm³; (15)Surface Tension: 39.0019989013672 dyne/cm; (16)Density: 1.036 g/cm³; (17)Flash Point: 90.344 °C; (18)Enthalpy of Vaporization: 50.93 kJ/mol; (19)Boiling Point: 225.772 °C at 760 mmHg; (20)Vapour Pressure: 0.0309999994933605 mmHg at 25°C

Preparation of Isoleucine: Isoleucine(CAS NO.73-32-5) can be produced with sugar, ammonia, D-threonine as raw material.Serratia spp race (Serratia marcescens) fermentation derived. Or with sugar, ammonia, α-amino butyric acid as raw material.And it derived from yellow cocci (Micrococcus flavum), or Bacillus subtilis (Bacillus subtilis; Aerobactor) fermentation.

When you are using this chemical, please be cautious about it as the following:
1. Avoid contact with skin and eyes
2. Wear suitable protective clothing
3. Do not breathe dust

You can still convert the following datas into molecular structure:
(1)InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1;
(2)InChIKey=AGPKZVBTJJNPAG-WHFBIAKZSA-N;
(3)SmilesC([C@H]([C@H](CC)C)N)(O)=O;

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rat	LD50	intraperitoneal	6822mg/kg (6822mg/kg)		Archives of Biochemistry and Biophysics. Vol. 58, Pg. 253, 1955.
rat	LD50	intraperitoneal	6822mg/kg (6822mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Archives of Biochemistry and Biophysics. Vol. 58, Pg. 253, 1955.

Product Name

L-Isoleucine

Synthetic route

Isoleucine Consensus Reports

Isoleucine Specification

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