Methanesulfonyl chloride supplier

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Name
Methanesulfonyl chloride
EINECS 204-706-1
CAS No. 124-63-0
Article Data97
CAS DataBase
Density 1.478 g/cm³
Solubility Slightly soluble in water, soluble in alcohol and ether
Melting Point -33 °C
Formula CH₃ClO₂S
Boiling Point 160.7 °C at 760 mmHg
Molecular Weight 114.553
Flash Point 42.2 °C
Transport Information UN 3246 6.1/PG 1
Appearance Colorless to yellow liquid
Safety 26-28-36/37/39-45-25
Risk Codes 24/25-26-34-37-35-22-41
Molecular Structure
Hazard Symbols T+,T,C
Synonyms Methane Sulfonyl Chloride;Methyl sulfonyl chloride;Chloro methyl sulfone;Mesyl chloride;Methylsulfonyl chloride;Methanesulfonic acid chloride;Methyl sulfochloride;Chloromethyl sulfone;
PSA 42.52000
LogP 1.26560

Synthetic route

: 624-92-0
Dimethyldisulphide

: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With hydrogenchloride; manganese(IV) oxide; potassium sulfate; water at 60 - 90℃; for 22h; Reagent/catalyst; Temperature; Large scale;	99.81%
With chloro-trimethyl-silane; potassium nitrate In dichloromethane at 50℃; for 8h;	90%

: 868-84-8
S,S-dimethyl dithiocarbonate

: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With water; chlorine at 5 - 10℃; for 0.25h;	95%

: 2344-80-1
Chloromethyltrimethylsilane

A: 1719-57-9
Chloro(chloromethyl)dimethylsilane

B: 20991-92-8
sulfate de bis-(dimethylchloromethylsilyle)

C: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With chlorosulfonic acid at 50 - 80℃;	A n/a B 92% C n/a

...Expand

: 766-92-7
[(methylthio)methyl]-benzene

: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With hydrogenchloride; iodosylbenzene for 0.0833333h; Chlorination; oxidation;	91%
With hydrogenchloride; iodosylbenzene for 0.0833333h;	91 % Chromat.

: 71954-24-0
N-chlorodimesylamine

: 3049-24-9
diphenyl phenylphosphonate

A: 102173-66-0
N-Mesyl-triphenoxyphosphinimid

B: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
In dichloromethane for 18h;	A 82% B n/a

...Expand

: 867-44-7
S-Methylisothiourea sulfate

: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With tert-butylhypochlorite In water; acetonitrile at 0 - 20℃;	79%
In diethyl ether; water at 0 - 20℃; for 0.5h; Green chemistry;	0.808 g

: 34557-54-5
methane

A: 75-09-2
dichloromethane

B: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With sulfur dioxide; chlorine at 25℃; under 2250.23 Torr; for 1h; Concentration; Wavelength; Irradiation;	A n/a B 69%

: 71954-24-0
N-chlorodimesylamine

A: 29651-24-9
N-Mesyl-trichlorphosphinimid

B: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With phosphorus trichloride In dichloromethane; chloroform for 12h;	A 61% B n/a

: 34557-54-5
methane

A: 56-23-5
tetrachloromethane

B: 74-87-3
methylene chloride

C: 75-09-2
dichloromethane

D: 67-66-3
chloroform

E: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With hydrogenchloride; sulfur dioxide; chlorine at 63 - 67℃; under 6750.68 Torr; Photolysis;	A n/a B n/a C n/a D n/a E 55%

...Expand

: 34557-54-5
methane

A: 75-09-2
dichloromethane

B: 67-66-3
chloroform

C: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With sulfur dioxide; chlorine at 65℃; under 2250.23 Torr; for 1h; Temperature; Irradiation;	A n/a B n/a C 54.9%

...Expand

: 5926-38-5
(dichloromethyl)trimethylsilane

A: 124-63-0
methanesulfonyl chloride

B: 107716-52-9
C3H7Cl3O3SSi

C: 107716-51-8
C3H7Cl3O3SSi

D: 107716-53-0
C6H14Cl4O4SSi2

Conditions

Conditions	Yield
at 90 - 100℃; Further byproducts given;	A n/a B 51% C n/a D n/a

...Expand

: 75-75-2
methanesulfonic acid

: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With 1,3,5-trichloro-2,4,6-triazine; triethylamine In acetone for 20h; Heating;	47%
With thionyl chloride at 95℃;
With phosphorus trichloride at 80℃;

: 34557-54-5
methane

: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With sulfur dioxide; chlorine at -10 - 110℃; for 2h; Product distribution / selectivity; Sealed reactor;	47%
With sulfuryl dichloride; sulfur trioxide; dihydrogen peroxide; rhodium(III) chloride; urea In sulfuric acid at 60℃; under 36201.3 Torr; for 12h;	1.9 mmol

: 34557-54-5
methane

A: 67-66-3
chloroform

B: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With sulfur dioxide; chlorine at 25℃; under 2250.23 Torr; for 1h; Temperature; Irradiation;	A n/a B 43.3%

: 676-85-7
methylsulphinyl chloride

: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With chlorine	13.5%

: 556-64-9
methyl thiocyanate

: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With water; chlorine
With water; chlorine

: 917-64-6
methyl magnesium iodide

: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With sulfuryl dichloride; diethyl ether at 10℃;

: 75-18-3
dimethylsulfide

: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With water; chlorine

: 5813-48-9
Methanesulfenyl chloride

: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With diethyl ether; nitric acid at -15℃;

: 14527-26-5, 867-44-7
2-methylisothiourea sulphate

: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With water; chlorine at 10 - 15℃;

: 7143-01-3
Methanesulfonic anhydride

: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With hydrogenchloride at 105℃;

: 592-76-7
1-Heptene

: 5799-68-8
methanedisulfonyl chloride

A: 5799-71-3
1,3-dichlorooctane

B: 5799-72-4
3-chloro-octanesulfonyl chloride

C: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With dibenzoyl peroxide In benzene Heating;

...Expand

: 64258-22-6
α,α-Dichlor-dimethylsulfid

: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With water; chlorine In acetic acid

: 676-85-7
methylsulphinyl chloride

A: 2949-92-0
methanethiosulfonic acid S-methyl ester

B: 75-18-3
dimethylsulfide

C: 13882-12-7
S-methyl methanethiosulfinate

D: 14128-56-4
methyl methanesulfinyl sulfone

E: 19186-23-3
Zinc methanesulfinate

F: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With zinc In various solvent(s) at -30℃; for 1.5h; Mechanism; Product distribution; var. solv., var. time, var. temp.;	A 7 % Spectr. B 1 % Spectr. C 3 % Spectr. D 1 % Spectr. E 5 % Spectr. F 9 % Spectr.

...Expand

: 676-85-7
methylsulphinyl chloride

A: 2949-92-0
methanethiosulfonic acid S-methyl ester

B: 75-18-3
dimethylsulfide

C: 22224-96-0
S-(chloromethyl) methanesulphonothioate

D: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
triethylamine In diethyl ether at 22 - 24℃; for 24h; Product distribution; other amines;	A 6 % Spectr. B 5 % Spectr. C 27 % Spectr. D 3 % Spectr.

...Expand

: 67-68-5
dimethyl sulfoxide

A: 2949-92-0
methanethiosulfonic acid S-methyl ester

B: 67-71-0
dimethylsulfone

C: 26394-12-7
hydrochloric acid, dimethyl sulphoxide

D: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With chlorine In dichloromethane at -0.1℃;
With chlorine In dichloromethane at -0.1℃; Further byproducts given;

...Expand

: 2081-44-9
Tetrahydro-pyran-4-ol

: 124-63-0
methanesulfonyl chloride

: 134419-59-3
4-oxanyl methanesulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 2.5h;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 2.5h;	100%
With triethylamine In dichloromethane at 0℃; for 1.5h;	100%

: 67-56-1
methanol

: 124-63-0
methanesulfonyl chloride

: 66-27-3
Methyl methanesulfonate

Conditions

Conditions	Yield
Stage #1: methanol With triethylamine In dichloromethane at 25℃; Stage #2: methanesulfonyl chloride In dichloromethane at 0 - 20℃;	100%
With pyridine; diethyl ether at -30℃;
With triethylamine

: 71-23-8
propan-1-ol

: 124-63-0
methanesulfonyl chloride

: 1912-31-8
propyl methanesulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 1h;	100%
With pyridine 1.) from -20 deg C to 30 deg C, 2.) room temp., 2 h;	65%
With pyridine at 0℃;

: 100-02-7
4-nitro-phenol

: 124-63-0
methanesulfonyl chloride

: 20455-07-6
p-nitrophenyl methanesulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 0.75h;	100%
With triethylamine In dichloromethane at 0 - 20℃;	98%
With triethylamine In ethyl acetate at 0 - 20℃; for 0.166667h; Green chemistry;	97%

: 821-09-0
n-Pent-4-enyl alcohol

: 124-63-0
methanesulfonyl chloride

: 64818-35-5
4-pentenyl mesylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at -15℃; for 1h; Green chemistry;	100%
With triethylamine In dichloromethane at -5℃; for 0.666667h;	98%
With triethylamine In dichloromethane at 0 - 20℃; for 91312.5h; Inert atmosphere;	98%

Methanesulfonyl chloride Chemical Properties

IUPAC Name: Methanesulfonyl chloride
Synonyms of Methanesulfonyl chloride (CAS NO.124-63-0): Mesyl chloride ; Methanesulfonic acid chloride ; Methanesulfonyl chloride ; Methanesulphonyl chloride
CAS NO: 124-63-0
Molecular Formula: CH₃ClO₂S
Molecular Weight: 114.54
Molecular Structure:
EINECS: 204-706-1
H bond acceptors: 2
H bond donors: 0
Freely Rotating Bonds: 0
Polar Surface Area: 42.52 Å²
Index of Refraction: 1.437
Molar Refractivity: 20.31 cm³
Molar Volume: 77.4 cm³
Surface Tension: 38.9 dyne/cm
Density: 1.478 g/cm³
Flash Point: 42.2 °C
Enthalpy of Vaporization: 38.09 kJ/mol
Boiling Point: 160.7 °C at 760 mmHg
Vapour Pressure: 3.07 mmHg at 25°C
Melting Point: -33°C
Storage temp: Store at R.T.
Sensitive: Moisture Sensitive
Appearance: Colorless to yellow liquid
Solubility: Slightly soluble in water, soluble in alcohol and ether
Product Categories of Methanesulfonyl chloride (CAS NO.124-63-0): Organics

Methanesulfonyl chloride Uses

Methanesulfonyl chloride (CAS NO.124-63-0) is used to make methanesulfonates and to generate sulfene. It is mainly used for the formation of methanesulfonates from alcohols and a non-nucleophilic base.

Methanesulfonyl chloride Production

Here are preparation, manufacture and handling of Methanesulfonyl chloride (CAS NO.124-63-0):
Methanesulfonyl chloride is manufactured either via direct synthesis from methane and sulfuryl chloride in a radical reaction (1):

CH₄ (g) + SO₂Cl₂ (g) → CH₃SO₂Cl + HCl (g) (1)
other method of manufacture starts with methanesulfonic acid, which is accessible out of methane and sulfur trioxide (2) or by vigorous oxidation of methanethiol (3):

CH₄(g) + SO₃ (g) → CH₃SO₃H (l) (2)
CH₃SH + HNO₃ → CH₃SO₃H + H₂O + NOx (3)
The methanesulfonic acid prepared is reacted with thionyl chloride (4) or phosgene (5) to form mesyl chloride:

CH₃SO₃H + SOCl₂ → CH₃SO₂Cl + SO₂ + HCl (4)
CH₃SO₃H + COCl₂ → CH₃SO₂Cl + CO₂ + HCl (5)

Methanesulfonyl chloride Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	skin	100uL/kg (0.1mL/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	National Technical Information Service. Vol. OTS0571119,
mouse	LD50	intraperitoneal	10mg/kg (10mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	National Technical Information Service. Vol. OTS0571119,
mouse	LD50	oral	200mg/kg (200mg/kg)	KIDNEY, URETER, AND BLADDER: HEMATURIA	National Technical Information Service. Vol. OTS0571119,
rat	LCLo	inhalation	620mg/m3/6H (620mg/m3)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS SKIN AND APPENDAGES (SKIN): HAIR: OTHER	National Technical Information Service. Vol. OTS0571119,
rat	LD50	oral	50mg/kg (50mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD KIDNEY, URETER, AND BLADDER: HEMATURIA	National Technical Information Service. Vol. OTS0571119,
rat	LDLo	intraperitoneal	5mg/kg (5mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD KIDNEY, URETER, AND BLADDER: HEMATURIA	National Technical Information Service. Vol. OTS0571119

Methanesulfonyl chloride Safety Profile

Safety Information about Methanesulfonyl chloride (CAS NO.124-63-0):
Hazard Codes: Very T+T, Corrosive C
Risk Statements: 24/25-26-34-37-35-22-41
R22: Harmful if swallowed.
R24/25: Toxic in contact with skin and if swallowed
R26: Very toxic by inhalation.
R34: Causes burns.
R35: Causes severe burns.
R37: Irritating to respiratory system
R41: Risk of serious damage to the eyes.
Safety Statements: 26-28-36/37/39-45-25
S25: Avoid contact with eyes.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S28: After contact with skin, wash immediately with plenty of soap-suds.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3246 6.1/PG 1
WGK Germany: 2
RTECS: PB2790000
Hazard Note: Toxic/Corrosive
HazardClass: 6.1
PackingGroup: I

Product Name

Methanesulfonyl chloride

Synthetic route

Methanesulfonyl chloride Chemical Properties

Methanesulfonyl chloride Uses

Methanesulfonyl chloride Production

Methanesulfonyl chloride Toxicity Data With Reference

Methanesulfonyl chloride Safety Profile

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