Methyl 4-formylbenzoate supplier

Name
Methyl 4-formylbenzoate
EINECS 216-385-5
CAS No. 1571-08-0
Article Data256
CAS DataBase
Density 1.181 g/cm³
Solubility insoluble in water,methanol: 0.1 g/mL
Melting Point 59-63 °C(lit.)
Formula C₉H₈O₃
Boiling Point 265 °C at 760 mmHg
Molecular Weight 164.161
Flash Point 144 °C
Transport Information
Appearance white crystalline powder
Safety 24/25
Risk Codes 36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xn
Synonyms Benzoicacid, 4-formyl-, methyl ester;4-Carbomethoxybenzaldehyde;4-Formylbenzoicacid methyl ester;Methyl benzaldehyde-4-carboxylate;NSC 28459;Para(methoxycarbonyl)benzaldehyde;p-Formylbenzoic acid methyl ester;
PSA 43.37000
LogP 1.28570

Synthetic route

: 6908-41-4
4-(methoxycarbonyl)benzyl alcohol

: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
With air; poly-alkylated (nitrosyl)Ru(salen) In toluene at 20℃; for 24h; Irradiation;	100%
With dmap; tetrakis(actonitrile)copper(I) hexafluorophosphate; N,N'-di-tert-butylethylenediamine; oxygen In dichloromethane at 20℃; under 760.051 Torr; for 3h; Schlenk technique; Molecular sieve; Sealed tube;	99%
With fluorosulfonyl fluoride; potassium carbonate; dimethyl sulfoxide at 20℃; for 12h; chemoselective reaction;	99%

: 101403-69-4
methyl 4-(diethoxymethyl)benzenecarboxylate

: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate In water at 30℃; for 3h;	100%

: 619-66-9
4-Carboxybenzaldehyde

: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
In methanol	100%
In dichloromethane
In dichloromethane
Multi-step reaction with 2 steps 1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C 2: copper(II) bis(trifluoromethanesulfonate) / 16 h / 20 °C View Scheme

: 53148-13-3
4-(hydroxyiminomethyl)benzoic acid methyl ester

: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
With hydrogenchloride In water; toluene at 20℃; for 4h; Reflux; Large scale;	98%

: 42228-16-0
methyl 4-(dimethoxymethyl)benzoate

: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In acetone at 20℃; for 20h;	98%

: 176208-43-8
methyl 4-[2-(methylthio)-1,3-dithian-2-yl]benzoate

: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
With water; 2,3-dicyano-5,6-dichloro-p-benzoquinone In acetonitrile for 3h; Ambient temperature;	97%
With p-benzoquinone; sodium iodide In water; acetonitrile at 100℃; for 31h;	86 %Spectr.

: 619-66-9
4-Carboxybenzaldehyde

: 4525-33-1
dimethyl dicarbonate

: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
magnesium(II) perchlorate In nitromethane at 40℃; for 16h;	97%

: 1774-35-2
di(p-tolyl) sulfoxide

: 6908-41-4
4-(methoxycarbonyl)benzyl alcohol

A: 620-94-0
di-(p-tolyl)sulfane

B: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
With per-rhenic acid In toluene for 24h; Reflux;	A 97% B 85%

...Expand

: 67-56-1
methanol

: 619-66-9
4-Carboxybenzaldehyde

: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
With acetyl chloride at 0 - 20℃;	96%
With thionyl chloride Ambient temperature;	95%
With thionyl chloride at 0 - 20℃;	93%

: 274250-98-5
4-quinolynylmethyl 4-formylbenzoate

: 74-88-4
methyl iodide

: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
Stage #1: 4-quinolynylmethyl 4-formylbenzoate With ammonium formate; 1,2-bis-(diphenylphosphino)ethane; bis(dibenzylideneacetone)-palladium(0) In dimethyl sulfoxide at 50℃; for 12h; Reduction; Deprotection; Stage #2: methyl iodide With sodium carbonate In water; dimethyl sulfoxide at 20℃; for 12h; Methylation;	96%

: 67-56-1
methanol

: 15226-74-1, 61091-28-9, 61117-58-6
dicobalt octacarbonyl

: 4-formylphenyl 2,3,4,5,6-pentafluorobenzenesulfonate

: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate at 20℃; for 16h; Schlenk technique; Inert atmosphere; chemoselective reaction;	96%

...Expand

: 2417-72-3
Methyl 4-(bromomethyl)benzoate

: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
With potassium hydrogencarbonate; dimethyl sulfoxide for 0.05h; Microwave irradiation;	95%
With pyridine N-oxide; silver(l) oxide In acetonitrile at 25℃;	81%
With ethanol; sodium 2-nitropropane
With methanol; hexamethylenetetramine
With 4-methylmorpholine N-oxide In acetonitrile at 0℃; Inert atmosphere; Molecular sieve;

: 59153-68-3
(4-(methoxycarbonyl)phenyl)methylene diacetate

: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
With potassium tert-butylate; 3-Dimethylaminophenol In tetrahydrofuran for 0.0833333h;	92%
With zirconium(IV) chloride In methanol at 20℃; for 0.1h;	89%

: 122357-96-4
4-(diethylaminocarbonyl)benzoic acid methyl ester

: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
With Schwartz's reagent In tetrahydrofuran at 20℃; for 0.416667h; Inert atmosphere;	92%
With Schwartz's reagent In tetrahydrofuran at 20℃; for 0.5h;	73%

: 862387-17-5
methyl 4-[(hydroxy)(1,2,3,4,5-pentamethyl-2,4-cyclopentadienyl)methyl]benzoate

A: 4045-44-7
1,2,3,4,5-pentamethylcyclopentadiene

B: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
With trichloroacetic acid In dichloromethane at 28℃; for 1.5h;	A n/a B 91%

: 67-56-1
methanol

: 1314659-42-1
4-formyl-N,N-bis(pyridin-2-ylmethyl)benzamide

: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
With copper(II) bis(trifluoromethanesulfonate) at 20℃; for 16h;	91%

: 64-18-6
formic acid

: 619-44-3
methyl 4-iodobenzoate

: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
With palladium diacetate; triethylamine; dicyclohexyl-carbodiimide; tricyclohexylphosphine In N,N-dimethyl-formamide at 60℃; for 10h; Inert atmosphere; Sealed tube;	91%
Stage #1: formic acid; methyl 4-iodobenzoate With palladium diacetate; acetic anhydride; tricyclohexylphosphine In N,N-dimethyl-formamide at 30℃; for 1h; Inert atmosphere; Green chemistry; Stage #2: With triethylamine In N,N-dimethyl-formamide at 80℃; for 6h; Inert atmosphere; Green chemistry;	79%
With iodine; triethylamine; triphenylphosphine In toluene at 80℃; Inert atmosphere; Sealed tube;	71%

: 15226-74-1, 61091-28-9, 61117-58-6
dicobalt octacarbonyl

: 619-42-1
4-methoxycarbonylphenyl bromide

: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
With triethylsilane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium acetate In acetonitrile at 60℃; for 16h; Schlenk technique; Inert atmosphere;	91%

: 15226-74-1, 61091-28-9, 61117-58-6
dicobalt octacarbonyl

: 17763-71-2
4-carbomethoxyphenyl triflate

: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
With triethylsilane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium acetate In acetonitrile at 25℃; for 16h; Schlenk technique; Inert atmosphere;	91%

: 201230-82-2
carbon monoxide

: 619-44-3
methyl 4-iodobenzoate

A: 93-58-3
benzoic acid methyl ester

B: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
With tri-n-butyl-tin hydride; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 50℃; under 2280 Torr;	A 8% B 90%
With hydrogen; potassium carbonate In 1,4-dioxane at 120 - 140℃; under 30003 Torr; for 20h; Autoclave;	A 45% B 8%

...Expand

: 201230-82-2
carbon monoxide

: 619-44-3
methyl 4-iodobenzoate

: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
With sodium formate In N,N-dimethyl-formamide at 110℃; under 760.051 Torr; for 4h;	90%
With sodium formate In N,N-dimethyl-formamide at 100℃; under 760.051 Torr; for 6h;	89%
With triethylsilane; palladium diacetate; sodium hydrogencarbonate; sodium carbonate at 20℃; under 760.051 Torr; for 24h;	83%
With poly-γ-(p-diphenylphosphinophenyl)propylsiloxane Pd; sodium acetate In N,N-dimethyl-formamide at 90℃; for 8h;	81%

: N-cyclohexyl-4-(methoxycarbonyl)benzamide

: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
Stage #1: N-cyclohexyl-4-(methoxycarbonyl)benzamide With 2-fluoropyridine; trifluoromethylsulfonic anhydride In dichloromethane at -78 - 0℃; Inert atmosphere; Stage #2: With triethylsilane In dichloromethane at 0 - 25℃; Inert atmosphere; Stage #3: With citric acid In tetrahydrofuran; dichloromethane; water at 45℃; for 2h; chemoselective reaction;	90%

: 229648-45-7
methyl 4-(isopropylcarbamoyl)benzoate

: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
Stage #1: methyl 4-(isopropylcarbamoyl)benzoate With 2-fluoropyridine; trifluoromethylsulfonic anhydride In dichloromethane at 0℃; for 0.333333h; Inert atmosphere; Stage #2: With 1,1,3,3-Tetramethyldisiloxane In dichloromethane at 0 - 20℃; for 6.16667h; Inert atmosphere; Stage #3: With hydrogenchloride In dichloromethane; water at 20℃; Inert atmosphere;	90%
Multi-step reaction with 3 steps 1: phosphorus pentachloride / dichloromethane / 20 °C / Schlenk technique 2: Dimethylphenylsilane; CpRu(PiPr3)(CH3CN)2PF6; tert-butyl isocyanide / dichloromethane-d2 / 0.5 h / 20 °C / Schlenk technique 3: hydrogenchloride; water / hexane View Scheme

: 18469-52-8
methyl 4-(aminomethyl)benzoate

: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
With copper(I) 2-hydroxy-3-methylbenzoate; oxygen; ascorbic acid In N,N-dimethyl acetamide at 40℃; for 2h; chemoselective reaction;	89%
With N-chloro-succinimide In water at 24.9℃; Kinetics; Thermodynamic data; pH 10.6; ΔH(excit.), ΔS(excit.);
With N-bromoacetamide In water at 14.9 - 34.9℃; Kinetics; Thermodynamic data; ΔH(excit.), ΔS(excit.);

: 1679-64-7
Monomethyl terephthalate

: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
With P(p-CH3OC6H4)3; methylphenylsilane; 2,2-dimethylpropanoic anhydride; bis(dibenzylideneacetone)-palladium(0) In toluene at 80℃; for 20h; Schlenk technique; Inert atmosphere;	89%
With bis-triphenylphosphine-palladium(II) chloride; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; Dimethylphenylsilane In toluene at 80℃; for 7h; Inert atmosphere; Sealed tube;	89%
With palladium(II) acetylacetonate; hydrogen; 2,2-dimethylpropanoic anhydride; dicyclohexylphenylphosphine In tetrahydrofuran at 80℃; under 3750.38 Torr; for 20h; Inert atmosphere;	80%

: 619-66-9
4-Carboxybenzaldehyde

: 616-38-6
carbonic acid dimethyl ester

: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 90℃; for 16h; Inert atmosphere; Green chemistry;	89%

: 619-66-9
4-Carboxybenzaldehyde

: 119-36-8
methyl salicylate

A: 69-72-7
salicylic acid

B: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
Stage #1: 4-Carboxybenzaldehyde With potassium carbonate In N,N-dimethyl acetamide at 110℃; for 0.5h; Stage #2: methyl salicylate at 110℃; for 24h;	A n/a B 89%

...Expand

: 619-66-9
4-Carboxybenzaldehyde

: 74-88-4
methyl iodide

: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃; for 1h;	88%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃; for 2h;	71%
With potassium carbonate In N-methyl-acetamide; water	4.7 g (84%)
With potassium carbonate In N,N-dimethyl-formamide at 60℃; Darkness;

: 67-56-1
methanol

: 15226-74-1, 61091-28-9, 61117-58-6
dicobalt octacarbonyl

: 17763-69-8
4-(trifluormethanesulfonyloxy)benzaldehyde

: 1571-08-0
methyl 4-formylbenzoate

Conditions

Conditions	Yield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate at 20℃; for 16h; Schlenk technique; Inert atmosphere; chemoselective reaction;	88%

...Expand

: 1571-08-0
methyl 4-formylbenzoate

: 1679-64-7
Monomethyl terephthalate

Conditions

Conditions	Yield
With phosphate-buffered silica gel supported KMnO4 In cyclohexane at 65℃;	100%
With chromium(VI) oxide; sulfuric acid In water; acetone at 0℃; Jones Oxidation;	97%
With selenium(IV) oxide; dihydrogen peroxide In tetrahydrofuran for 5h; Heating;	95%

: 126-30-7
2,2-Dimethyl-1,3-propanediol

: 1571-08-0
methyl 4-formylbenzoate

: 138536-73-9
4-(5,5-Dimethyl-[1,3]dioxan-2-yl)-benzoic acid methyl ester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 2h; Heating;	100%
With toluene-4-sulfonic acid In toluene for 24h; Reflux;	66%

: 7677-24-9
trimethylsilyl cyanide

: 1571-08-0
methyl 4-formylbenzoate

: 93555-00-1
methyl 4-(cyano(trimethylsilyloxy)methyl)benzoate

Conditions

Conditions	Yield
In diethyl ether at 0℃; for 1h;	100%
With Al(3+)*C36H48NO3(3-) In acetonitrile at 20℃; for 9.5h; Inert atmosphere; Schlenk techniques;	92%
With iodine In dichloromethane at 20℃; for 0.05h;	90%

: 3017-53-6
benzyl 2-bromopropionate

: 1571-08-0
methyl 4-formylbenzoate

: 122594-12-1
benzyl 2-methyl-3-hydroxy-p-carbomethoxyhydrocinnamate

Conditions

Conditions	Yield
With iodine; zinc In benzene for 18h; Heating;	100%

: 42115-51-5
2-bromobutyric acid benzyl ester

: 1571-08-0
methyl 4-formylbenzoate

: 122594-13-2
4-(2-Benzyloxycarbonyl-1-hydroxy-butyl)-benzoic acid methyl ester

Conditions

Conditions	Yield
With iodine; zinc In benzene Heating;	100%

: (Z)-2-(1-methoxyethyl)-2,4-pentadienyltrimethyltin

: 1571-08-0
methyl 4-formylbenzoate

: 4-((1S,2R,4R)-1-Hydroxy-4-methoxy-3-methylene-2-vinyl-pentyl)-benzoic acid methyl ester

Conditions

Conditions	Yield
With TiCl4*Et2O In dichloromethane at -78℃; for 2h;	100%

: 1571-08-0
methyl 4-formylbenzoate

: 6908-41-4
4-(methoxycarbonyl)benzyl alcohol

Conditions

Conditions	Yield
With sodium tetrahydroborate In ethanol at 5℃; for 0.5h;	100%
With zirconium dioxide hydrate; isopropyl alcohol at 60℃; for 0.133333h; Meerwein-Ponndorf-Verley Reduction;	100%
Stage #1: methyl 4-formylbenzoate With polymethylhydrosiloxane; iron(II) acetate; tricyclohexylphosphine In tetrahydrofuran at 65℃; for 16h; Stage #2: With sodium hydrogencarbonate In tetrahydrofuran; methanol at 0 - 20℃; Further stages.;	99%

: 141-82-2
malonic acid

: 1571-08-0
methyl 4-formylbenzoate

: 19473-96-2
4-(2-carboxyvinyl)benzoic acid methyl ester

Conditions

Conditions	Yield
With piperidine; pyridine at 120℃; for 12h;	100%
With piperidine In pyridine at 100 - 120℃; for 19h;	99.39%
With piperidine; pyridine at 80 - 100℃; for 4h;	91.6%
With piperidine; pyridine at 110℃; for 2h;	75%
With piperidine; pyridine for 5h; Reflux;	36%

: 26138-64-7
3-acetyl-2,4-dihydroxyquinoline

: 1571-08-0
methyl 4-formylbenzoate

: 4-[(E)-3-(2,4-Dihydroxy-quinolin-3-yl)-3-oxo-propenyl]-benzoic acid methyl ester

Conditions

Conditions	Yield
	100%

: 100-46-9
benzylamine

: 1571-08-0
methyl 4-formylbenzoate

: 193821-09-9
N-benzyl-(4-methoxycarbonylphenyl)methanimine

Conditions

Conditions	Yield
In toluene for 15.5h; Heating;	100%
With 4 A molecular sieve In methanol for 4h; Heating;	96%
In methanol

: 1571-08-0
methyl 4-formylbenzoate

: 168699-41-0
methyl 4-[(1E)-(hydroxyimino)methyl]benzoate

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; sodium acetate In methanol; water Reflux;	100%
With hydroxylamine hydrochloride; sodium acetate In methanol; water for 0.5h; Reflux;	79%
With hydroxylamine hydrochloride; sodium hydrogencarbonate In methanol at 20℃; for 4h;	60%

: 4231-62-3
1-benzoyl-1H-benzotriazole

: 1571-08-0
methyl 4-formylbenzoate

: methyl 4-<1H-1,2,3-benzotriazol-1-yl(benzoyloxy)methyl> benzoate

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 20℃; for 10h;	100%

: 124-09-4
1,6-Hexanediamine

: 1571-08-0
methyl 4-formylbenzoate

: 106872-64-4
1,6-bis(4-methoxycarbonylbenzylidene)hexanediamine

Conditions

Conditions	Yield
In toluene for 0.5h; Condensation; Heating;	100%
In toluene for 1h; Reflux; Dean-Stark trap;	100%

: 606-23-5
1H-indene-1,3(2H)-dione

: 1896-62-4
(E)-benzalacetone

: 1571-08-0
methyl 4-formylbenzoate

: 2-[4-(methoxycarbonyl)phenyl]-6-phenylspiro[cyclohexane-1,2'-indan]-1',3',4-trione

Conditions

Conditions	Yield
Stage #1: 1H-indene-1,3(2H)-dione; methyl 4-formylbenzoate With L-proline In methanol at 20℃; for 0.5h; organocatalytic Knoevenagel condensation; Stage #2: (E)-benzalacetone In methanol at 25℃; for 96h; Diels-Alder/epimerization reaction;	100%

...Expand

: 72476-03-0
(E)-3-methyl-4-methoxy-2-[(trimethylsilyl)oxy]-1,3-butadiene

: 1571-08-0
methyl 4-formylbenzoate

: 4-(5-methyl-4-oxo-3,4-dihydro-2H-pyran-2-yl)-benzoic acid methyl ester

Conditions

Conditions	Yield
Stage #1: (E)-3-methyl-4-methoxy-2-[(trimethylsilyl)oxy]-1,3-butadiene; methyl 4-formylbenzoate With lithium methanolate In N,N-dimethyl-formamide at 0℃; Mukaiyama aldol addition; Stage #2: With trifluoroacetic acid In N,N-dimethyl-formamide at 0℃;	100%

: 94190-73-5
(1H,1H,2H,2H-perfluorooctyl)triphenylphosphonium iodide

: 1571-08-0
methyl 4-formylbenzoate

: 944720-88-1
C17H11F13O2

Conditions

Conditions	Yield
With potassium carbonate In 1,4-dioxane; water Wittig reaction; Heating;	100%

: 1000533-03-8
2-(5-fluoro-2-methoxyphenyl)ethanamine

: 1571-08-0
methyl 4-formylbenzoate

: 4-({[2-(5-fluoro-2-methoxyphenyl)ethyl]imino}methyl)benzoic acid methyl ester

Conditions

Conditions	Yield
In ethanol for 2h; Heating / reflux;	100%

: 3300-51-4
p-Trifluoromethylbenzylamine

: 1571-08-0
methyl 4-formylbenzoate

: 1276692-13-7
N-(4-(methylcarboxy)benzylidene)-p-trifluoromethylbenzylamine

Conditions

Conditions	Yield
In toluene Reflux;	100%

: tert-butyl 1-(2-bromobenzyl)hydrazine-1-carboxylate

: 1571-08-0
methyl 4-formylbenzoate

: C21H23BrN2O4

Conditions

Conditions	Yield
In ethanol at 20℃;	100%

: 20781-20-8
2,4-Dimethoxybenzylamine

: 1571-08-0
methyl 4-formylbenzoate

: methyl (E)-4-(2,4-dimethoxybenzyliminomethyl)benzoate

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; for 12h; Inert atmosphere;	100%

: 7677-24-9
trimethylsilyl cyanide

: 2038-57-5
3-Phenylpropan-1-amine

: 1571-08-0
methyl 4-formylbenzoate

: 1108730-71-7
methyl 4-[cyano(3-phenylpropylamino)methyl]benzoate

Conditions

Conditions	Yield
With polymer-supported scandium(III) bis(trifluoromethanesulfonate) In acetonitrile at 20℃; for 1h; Strecker reaction; Combinatorial reaction / High throughput screening (HTS); chemoselective reaction;	99.9%

...Expand

: 7677-24-9
trimethylsilyl cyanide

: 64-04-0
phenethylamine

: 1571-08-0
methyl 4-formylbenzoate

: 1108730-70-6
methyl 4-[cyano(phenethylamino)methyl]benzoate

Conditions

Conditions	Yield
With polymer-supported scandium(III) bis(trifluoromethanesulfonate) In acetonitrile at 20℃; for 1h; Strecker reaction; Combinatorial reaction / High throughput screening (HTS); chemoselective reaction;	99.9%

...Expand

: 7677-24-9
trimethylsilyl cyanide

: 62-53-3
aniline

: 1571-08-0
methyl 4-formylbenzoate

: 1108730-68-2
methyl 4-[cyano(phenylamino)methyl]benzoate

Conditions

Conditions	Yield
With polymer-supported scandium(III) bis(trifluoromethanesulfonate) In acetonitrile at 20℃; for 1h; Strecker reaction; Combinatorial reaction / High throughput screening (HTS); chemoselective reaction;	99.8%
With polymer-supported gallium(III) bis(trifluoromethanesulfonate) In dichloromethane at 40℃; under 15001.5 Torr; for 1h; Strecker reaction; Microreactor;	99.9%

...Expand

: 7677-24-9
trimethylsilyl cyanide

: 100-46-9
benzylamine

: 1571-08-0
methyl 4-formylbenzoate

: 1108730-69-3
methyl 4-((benzylamino)(cyano)methyl)benzoate

Conditions

Conditions	Yield
With polymer-supported scandium(III) bis(trifluoromethanesulfonate) In acetonitrile at 20℃; for 1h; Strecker reaction; Combinatorial reaction / High throughput screening (HTS); chemoselective reaction;	99.9%

...Expand

: 105-56-6
ethyl 2-cyanoacetate

: 1571-08-0
methyl 4-formylbenzoate

: C14H13NO4

Conditions

Conditions	Yield
With piperazine In acetonitrile for 1h; Knoevenagel condensation; electroosmos;	99.8%

: 1571-08-0
methyl 4-formylbenzoate

: 53148-13-3
4-(hydroxyiminomethyl)benzoic acid methyl ester

Conditions

Conditions	Yield
Stage #1: methyl 4-formylbenzoate With hydroxylamine hydrochloride In methanol; water at 25 - 35℃; for 2h; Stage #2: With sodium hydroxide In methanol; water pH=7.5 - 8;	99.5%
Stage #1: methyl 4-formylbenzoate With hydroxylamine hydrochloride; 5%-palladium/activated carbon In methanol; water at 25 - 35℃; for 2h; Stage #2: With sodium hydroxide In methanol; water pH=7.5 - 8; Product distribution / selectivity;	99.5%
With hydroxylamine hydrochloride In methanol; water at 20℃; for 6h; Large scale;	95%

: 1571-08-0
methyl 4-formylbenzoate

: 149-73-5
trimethyl orthoformate

: 42228-16-0
methyl 4-(dimethoxymethyl)benzoate

Conditions

Conditions	Yield
With *OTf3 In methanol for 5h; Ambient temperature;	99%
With amberlyst-15 In acetonitrile for 1h; electroosmos;	99.4%
With amberlyst-15 In acetonitrile for 0.166667h;	95.3%

Methyl 4-formylbenzoate Chemical Properties

Empirical Formula: C₉H₈O₃
Molecular Weight: 164.158 g/mol
Index of Refraction: 1.557
Density: 1.181 g/cm³
Flash Point: 122.5 °C
Water solubility: Insoluble
Sensitive: Air Sensitive
Melting point: 59-63 °C(lit.)
Enthalpy of Vaporization: 50.29 kJ/mol
Boiling Point: 265 °C at 760 mmHg
Vapour Pressure: 0.0094 mmHg at 25 °C
Solubility: Methanol : 0.1 g/mL, clear
Appearance: White crystalline powder
Structure of Methyl 4-formylbenzoate (CAS NO.1571-08-0):

IUPAC Name: Methyl 4-formylbenzoate
Product Category of Methyl 4-formylbenzoate (CAS NO.1571-08-0): Intermediates of Dyes and Pigments;Aromatic Aldehydes & Derivatives (substituted)

Methyl 4-formylbenzoate Uses

Methyl 4-formylbenzoate (CAS NO.1571-08-0) can be used as drugs' intermediate and fluorescent brighteners' intermediate.

Methyl 4-formylbenzoate Toxicity Data With Reference

Methyl 4-formylbenzoate (CAS NO.1571-08-0) hasn't been listed as a carcinogen by NTP, IARC, ACGIH, or CA Prop 65. And the toxicological properties have not been fully investigated.

Methyl 4-formylbenzoate Safety Profile

Hazard Codes: Harmful Xn, Irritant Xi
Risk Statements: 36/37/38-20/21/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.

Methyl 4-formylbenzoate Specification

Methyl 4-formylbenzoate , its cas register number is 1571-08-0. It also can be called 4-Carbomethoxybenzaldehyde; p-Carbomethoxybenzaldehyde ; 4-(Methoxycarbonyl)benzaldehyde ; Methyl benzaldehyde-4-carboxylate ; Methyl terephthalaldehydate ; and 4-Carboxybenzaldehyde methyl ester . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product: Wash mouth out with water, and get medical aid immediately. Notes to physician: Treat supportively and symptomatically.
In addition, Methyl 4-formylbenzoate (CAS NO.1571-08-0) is not compatible with strong oxidizing agents, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: carbon monoxide, carbon dioxide.

Product Name

Methyl 4-formylbenzoate

Synthetic route

Methyl 4-formylbenzoate Chemical Properties

Methyl 4-formylbenzoate Uses

Methyl 4-formylbenzoate Toxicity Data With Reference

Methyl 4-formylbenzoate Safety Profile

Methyl 4-formylbenzoate Specification

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