Methylamine supplier | CasNO.74-89-5

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Name
Methylamine
EINECS 200-820-0
CAS No. 74-89-5
Article Data911
CAS DataBase
Density 0.70 g/cm³
Solubility Soluble in water, ethanol and ether
Melting Point -93 °C
Formula CH₅N
Boiling Point -6.5 °C
Molecular Weight 31.0574
Flash Point 61°F
Transport Information UN 1061
Appearance colourless gas
Safety 7-16-26-36/37-45-29-36/37/39-3/7-3-39-33
Risk Codes 12-20-37/38-41-34-20/22-11-39/23/24/25-36/37/38-23/24/25
Molecular Structure
Hazard Symbols F+, Xn, C, F, T
Synonyms Methylamine(8CI);Aminomethane;Carbinamine;Monomethylamine;Methylamine;
PSA 26.02000
LogP 0.27520

Synthetic route

: 107-97-1
sarcosine

A: 50-00-0
formaldehyd

B: 124-38-9
carbon dioxide

C: 74-89-5
methylamine

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide; sodium perchlorate; chlorine at 24.9℃; Mechanism; Rate constant; Equilibrium constant; multistep reaction: 1.) water, 298 deg K, 2.) water, 298 deg K; reactions under var. conditions;	A 100% B n/a C n/a

...Expand

: 52316-59-3
N-chloro-sarcosine

A: 50-00-0
formaldehyd

B: 74-89-5
methylamine

Conditions

Conditions	Yield
In water at 24.9℃; Rate constant; Mechanism; Thermodynamic data; Irradiation; I=0.5 mol-1 L-1; various pH; ΔH(excit.), ΔS(excit.);	A 100% B n/a
With water In 1,4-dioxane at 25℃;
With water In 1,4-dioxane at 25℃; Kinetics; Mechanism;

: 60-35-5
acetamide

: 79483-05-9
4,5-diethyl-2,5-dihydro-1,2,2,3-tetramethyl-1H-1,2,5-azasilaborole

A: 111869-87-5
ethylbis(dimethyl(2-penten-2-yl)silyloxy)borane

B: 74-89-5
methylamine

Conditions

Conditions	Yield
In 1,2,5-trimethyl-benzene dropwise addn. of acetamide to boron compd. soln., 160°C, 3.5h; heating (reflux), 10h; evapn.; all under Ar; distn.; elem. anal.;	A 100% B 98%

...Expand

: 75-52-5
nitromethane

: 74-89-5
methylamine

Conditions

Conditions	Yield
With borane-ammonia complex In methanol; water at 20℃; for 0.0833333h;	99%
With ammonia borane; Pd/MIL-101 In methanol; water at 20℃; for 0.025h;	99%
With sodium tetrahydroborate In methanol; water at 20℃; for 0.0666667h; Sealed tube; Green chemistry;	99%

: 110-89-4
piperidine

: 110-68-9
N-n-butyl-N-methylamine

A: 4945-48-6
1-butyl-piperidine

B: 74-89-5
methylamine

Conditions

Conditions	Yield
palladium at 160℃; for 5h;	A 98% B n/a

...Expand

: 110-89-4
piperidine

: 103-67-3
benzyl-methyl-amine

A: 2905-56-8
N-Benzylpiperidine

B: 74-89-5
methylamine

Conditions

Conditions	Yield
palladium at 130℃; for 10h;	A 97% B n/a

...Expand

: 1-methyl-2-methylamino-4-imino-6-(2,3-dimethylguanidino)-1,4-dihydro-1,3,5-triazine

A: 6726-47-2
1-methyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione

B: 3324-71-8
N,N'-dimethyl-guanidine

C: 74-89-5
methylamine

Conditions

Conditions	Yield
With hydrogenchloride for 10h; Heating;	A 15% B 96% C 4%

...Expand

: 96-31-1
N,N'-Dimethylurea

: 18522-92-4
sodium p-toluenesulfonamide

A: 13909-69-8
N-Methyl-N'-toluene-p-sulfonylurea

B: 74-89-5
methylamine

Conditions

Conditions	Yield
at 160℃; for 3h; Product distribution; Rate constant; Equilibrium constant; Other temperature, other time, other ratio of reactants, activation energy, ΔH, ΔS;;	A 95.5% B n/a
at 160℃; for 3h;	A 95.5% B n/a

...Expand

: 107-15-3
ethylenediamine

: 103-67-3
benzyl-methyl-amine

A: 74-89-5
methylamine

B: 4152-09-4
N-benzylethylenediamine

Conditions

Conditions	Yield
palladium at 120℃; for 10h;	A n/a B 95%

...Expand

: 13325-10-5
4-Aminobutanol

: 79483-05-9
4,5-diethyl-2,5-dihydro-1,2,2,3-tetramethyl-1H-1,2,5-azasilaborole

A: 129363-73-1
4,5-diethyl-2,2,3-trimethyl-6-oxa-1-azonia-2-sila-5-boratabicyclo{5.3.0}dec-3-ene

B: 129363-50-4
4,5-diethyl-2,2,3-trimethyl-1-oxa-6-aza-2-sila-5-bora-3-cyclodecene

C: 74-89-5
methylamine

Conditions

Conditions	Yield
In neat (no solvent) addn. of boron compd. to equimolar amt. of aminoalkanol, room temp.; driving out CH3NH2 in a stream of Ar, 20-80°C, 4h;; distn. (vac.); elem. anal.; monocyclic : bicyclic isomer = 95:5;	A n/a B n/a C 95%

...Expand

: 79878-19-6
6-methyl-8-nitro-1,6-naphthyridin-5(6H)-one

A: 90004-07-2
8-methylpyrido<2,3-d>pyridazin-5-one

B: 74-89-5
methylamine

C NH3: NH3

Conditions

Conditions	Yield
With hydrazine hydrate at 130 - 140℃; for 5h;	A 94% B n/a C n/a

...Expand

: 79483-05-9
4,5-diethyl-2,5-dihydro-1,2,2,3-tetramethyl-1H-1,2,5-azasilaborole

: 141-43-5
ethanolamine

A: 129363-47-9
4,5-diethyl-2,2,3-trimethyl-1-oxa-6-aza-2-sila-5-bora-3-cyclooctene

B: 74-89-5
methylamine

Conditions

Conditions	Yield
In 1,2,5-trimethyl-benzene heating under Ar, 40-70°C, 4h;	A 93% B 93%
In neat (no solvent) addn. of boron compd. to equimolar amt. of aminoalkanol, room temp.; driving out CH3NH2 in a stream of Ar, 20°C, 24h;; distn. (vac.); elem. anal.;	A 82% B 87%

...Expand

: 5856-63-3
(2R)-2-aminobutan-1-ol

: 79483-05-9
4,5-diethyl-2,5-dihydro-1,2,2,3-tetramethyl-1H-1,2,5-azasilaborole

A: 129444-01-5
(R)-4,5,7-triethyl-2,2,3-trimethyl-6-oxa-1-azonia-2-sila-5-boratabicyclo{3.3.0}oct-3-ene

B: 129444-00-4
(R)-4,5,7-triethyl-2,2,3-trimethyl-1-oxa-6-aza-2-sila-5-bora-3-cyclooctene

C: 74-89-5
methylamine

Conditions

Conditions	Yield
In neat (no solvent) addn. of boron compd. to equimolar amt. of aminoalkanol, room temp.; driving out CH3NH2 in a stream of Ar, 20-25°C, 18h; distn. (vac.); elem. anal.; monocyclic : bicyclic isomer = 95:5;	A n/a B n/a C 91%

...Expand

: 123-75-1
pyrrolidine

: 103-67-3
benzyl-methyl-amine

A: 4383-25-9
N-benzylcyclohexylamine

B: 2211-66-7
N-phenyl(methylidene)cyclohexanamine

C: 74-89-5
methylamine

Conditions

Conditions	Yield
palladium at 120℃; for 10h;	A 10% B 90% C n/a

...Expand

: 96-20-8, 13054-87-0
2-aminobutanol

: 79483-05-9
4,5-diethyl-2,5-dihydro-1,2,2,3-tetramethyl-1H-1,2,5-azasilaborole

A: 129363-71-9
4,5,7-triethyl-2,2,3-trimethyl-6-oxa-1-azonia-2-sila-5-boratabicyclo{3.3.0}oct-3-ene

B: 129363-48-0
4,5,7-triethyl-2,2,3-trimethyl-1-oxa-6-aza-2-sila-5-bora-3-cyclooctene

C: 74-89-5
methylamine

Conditions

Conditions	Yield
In neat (no solvent) addn. of boron compd. to equimolar amt. of aminoalkanol, room temp.; driving out CH3NH2 in a stream of Ar, 20-25°C, 22h; distn. (vac.); elem. anal.; monocyclic: bicyclic isomer = 95:5;	A n/a B n/a C 89%

...Expand

: 160745-23-3
N-methylisoephedrine

A: 52500-61-5
2-hydroxy-1-phenylpropylamine

B: 50-00-0
formaldehyd

C: 100-52-7
benzaldehyde

D: 75-07-0
acetaldehyde

E: 124-40-3
dimethyl amine

F: 74-89-5
methylamine

Conditions

Conditions	Yield
With water at 25℃; Product distribution; Mechanism; anodic oxidation, carbonate buffer, pH 10; effect of substituents investigated with different types of β-alkanolamines;	A 1.3% B 28% C 82% D 88% E 38% F 33%

...Expand

: 79483-05-9
4,5-diethyl-2,5-dihydro-1,2,2,3-tetramethyl-1H-1,2,5-azasilaborole

: 591-27-5
m-Hydroxyaniline

A: 129390-09-6
C30H48B2N2O2Si2

B: 74-89-5
methylamine

Conditions

Conditions	Yield
In 1,2,5-trimethyl-benzene at 125-150°C, 26h under Ar; evapn.; elem. anal.;	A n/a B 88%

...Expand

: 3913-67-5
N-methylalanine

A: 124-38-9
carbon dioxide

B: 75-07-0
acetaldehyde

C: 74-89-5
methylamine

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide; sodium perchlorate; chlorine at 24.9℃; Mechanism; Rate constant; Equilibrium constant; multistep reaction: 1.) water, 298 deg K, 2.) water, 298 deg K; reactions under var. conditions;	A n/a B 87% C n/a

...Expand

: 299-42-3
2-methylamino-1-phenylpropanol

A: 50-00-0
formaldehyd

B: 100-52-7
benzaldehyde

C: 75-07-0
acetaldehyde

D: 65-85-0
benzoic acid

E: 74-89-5
methylamine

Conditions

Conditions	Yield
Mechanism; Product distribution; anodic oxidation;	A 12% B 65% C 68% D 12% E 87%

...Expand

: 81620-70-4
4,5-diethyl-2,5-dihydro-3-isopropenyl-1,2,2-trimethyl-1,2,5-azasilaborole

: 141-43-5
ethanolamine

A: 129363-59-3
4,5-diethyl-3-isopropenyl-2,2-dimethyl-1-oxa-6-aza-2-sila-5-bora-3-cyclooctene

B: 129363-70-8
4,5-diethyl-3-isopropenyl-2,2-dimethyl-6-oxa-1-azonia-2-sila-5-boratabicyclo{3.3.0}oct-3-ene

C: 74-89-5
methylamine

Conditions

Conditions	Yield
In neat (no solvent) addn. of boron compd. to equimolar amt. of aminoalkanol, room temp.; driving out CH3NH2 in a stream of Ar, 20-25°C, 22h;; distn. (vac.); standing at room temp.; crystn. of bicyclic isomer; elem. anal.;	A 57% B n/a C 87%

...Expand

: 79483-05-9
4,5-diethyl-2,5-dihydro-1,2,2,3-tetramethyl-1H-1,2,5-azasilaborole

: 156-87-6
propan-1-ol-3-amine

A: 129363-72-0
4,5-diethyl-2,2,3-trimethyl-6-oxa-1-azonia-2-sila-5-boratabicyclo{4.3.0}non-3-ene

B: 129363-49-1
4,5-Diethyl-2,2,3-trimethyl-1-oxa-6-aza-2-sila-5-bora-3-cyclononene

C: 74-89-5
methylamine

Conditions

Conditions	Yield
In neat (no solvent) addn. of boron compd. to equimolar amt. of aminoalkanol, room temp.; driving out CH3NH2 in a stream of Ar, 20-80°C, 24h;; distn. (vac.); elem. anal.; monocyclic : bicyclic isomer = 95:5;	A n/a B n/a C 87%

...Expand

: 90-82-4
pseudoephedrine

: 79483-05-9
4,5-diethyl-2,5-dihydro-1,2,2,3-tetramethyl-1H-1,2,5-azasilaborole

A: 129363-65-1
(4S,5S)-2-Ethyl-4-methyl-5-phenyl-1,3,2-oxazaborolan

B: 129363-66-2
{(1S,2S)-2-[Dimethyl-((E)-1-methyl-but-1-enyl)-silanyloxy]-1-methyl-2-phenyl-ethyl}-methyl-amine

C: 129443-99-8
(7S,8S)-4,5-Diethyl-2,2,3,6,7-pentamethyl-8-phenyl-1-oxa-6-aza-2-sila-5-bora-3-cycloocten

D: 74-89-5
methylamine

Conditions

Conditions	Yield
In 1,2,5-trimethyl-benzene dropwise addn. of boron compd. to aminoalkanol soln. under Ar, 0.5h; heating to 140-150°C, 12h; evapn.; distn. (vac.); elem. anal.;	A n/a B n/a C 75% D 86%

...Expand

: 60-35-5
acetamide

: 74-89-5
methylamine

Conditions

Conditions	Yield
With sodium hydroxide; benzyltrimethylazanium tribroman-2-uide In water at 70℃; for 2h;	85%
With potassium hydroxide; bromine ueber mehrere Stufen;
With potassium hydroxide; bromine
With water; bromine; calcium carbonate ueber mehrere Stufen;
With sodium hydroxide; sodium bromite In water at 70℃; for 0.5h; Yield given;

: 103-67-3
benzyl-methyl-amine

A: 102-05-6
N-methyldibenzylamine

B: 74-89-5
methylamine

Conditions

Conditions	Yield
palladium at 120℃; for 20h;	A 85% B n/a

: 108-01-0
2-(N,N-dimethylamino)ethanol

: 79483-05-9
4,5-diethyl-2,5-dihydro-1,2,2,3-tetramethyl-1H-1,2,5-azasilaborole

A: 129363-54-8
(E)-3-<<2-(Dimethylamino)ethoxy>ethylboryl>-2-<<2-(dimethylamino)ethoxy>dimethylsilyl>-2-penten

B: 74-89-5
methylamine

Conditions

Conditions	Yield
In neat (no solvent) stirring under Ar, 0-20°C, 1-2h; heating to a maximum of 140°C, 10h; distn. (vac.); elem. anal.;	A 82% B 76%

...Expand

: 109-83-1
(2-hydroxyethyl)(methyl)amine

: 79483-05-9
4,5-diethyl-2,5-dihydro-1,2,2,3-tetramethyl-1H-1,2,5-azasilaborole

A: 129363-52-6
4,5-diethyl-2,2,3,6-tetramethyl-1-oxa-6-aza-2-sila-5-bora-3-cyclooctene

B: 74-89-5
methylamine

Conditions

Conditions	Yield
In neat (no solvent) dropwise addn. of boron compd. to aminoalkanol, 10 min; stirring in a stream of Ar, 20°C, 24h;; distn. (vac.); elem. anal.;	A 81% B 82%

...Expand

: 854457-30-0
trimethyl-borane; compound with methylamine

A: 593-90-8
trimethylborane

B: 74-89-5
methylamine

Conditions

Conditions	Yield
at 130.0°C, 77.4 Torr equilibrium;	A 81.95% B 81.95%
at 130.0°C, 77.4 Torr equilibrium;	A 81.95% B 81.95%
at 85.4°C, 52.5 Torr equilibrium;	A 38.86% B 38.86%
at 85.4°C, 52.5 Torr equilibrium;	A 38.86% B 38.86%

: 299-42-3
L(-)-ephedrine hemihydrate

: 79483-05-9
4,5-diethyl-2,5-dihydro-1,2,2,3-tetramethyl-1H-1,2,5-azasilaborole

A: 129363-53-7
(7S,8R)-4,5-diethyl-2,2,3,6,7-pentamethyl-1-oxa-6-aza-2-sila-5-bora-3-cyclooctene

B: 74-89-5
methylamine

Conditions

Conditions	Yield
In neat (no solvent) dropwise addn. of boron compd. to aminoalkanol under Ar, 5 min; heating to 110-150°C, 8.5h;; distn. (vac.); elem. anal.;	A 73% B 80.5%

...Expand

: 110-68-9
N-n-butyl-N-methylamine

: 103-67-3
benzyl-methyl-amine

A: 31844-65-2
N-Butyl-N-methylbenzenemethanamine

B: 74-89-5
methylamine

Conditions

Conditions	Yield
palladium at 120℃; for 10h;	A 80% B n/a

...Expand

: 123-56-8
Succinimide

: 74-89-5
methylamine

: 3025-97-6
N-methyl-succinic diamide

Conditions

Conditions	Yield
at 20℃; under 600.048 - 750.06 Torr; Addition; soid-gas reaction; ring cleavage;	100%
With water
In water for 1h; Ambient temperature;

: 487-89-8
Indole-3-carboxaldehyde

: 74-89-5
methylamine

: 22980-06-9
3-(N-methylformimidoyl)-1H-indole

Conditions

Conditions	Yield
With magnesium sulfate In methanol; dichloromethane for 7h; Heating;	100%
With water
In water 1.) 40 - 45 deg C, 15 min, 2.) room temp., 4 h; Yield given;

: 87-41-2
2-benzofuran-1(3H)-one

: 74-89-5
methylamine

: 5342-91-6
2-methylisoindolin-1-one

Conditions

Conditions	Yield
In water at 220℃; under 114000 Torr; for 4h;	100%
With ethanol at 220℃;
In 5,5-dimethyl-1,3-cyclohexadiene

: 136918-14-4
phthalimide

: 74-89-5
methylamine

: 19532-98-0
N1,N2-dimethylphthalamide

Conditions

Conditions	Yield
at -20℃; under 75.006 Torr; Addition; solid-gas reaction; ring cleavage;	100%
In ethanol	55%

: 81-84-5
1,8-Naphthalic anhydride

: 74-89-5
methylamine

: 2382-08-3
N-methylnaphthalimide

Conditions

Conditions	Yield
In ethanol; water at 20℃; for 72h; Inert atmosphere;	100%
In water for 72h; Reflux;	100%
In water	100%

: 4295-06-1
4-chloro-2-methylquinoline

: 74-89-5
methylamine

: 21875-68-3
N,2-dimethylquinolin-4-amine

Conditions

Conditions	Yield
In ethanol at 120℃; for 7h; Sealed tube; Microwave irradiation;	100%
With ethanol at 120℃;
With phenol at 190℃;

: 104-87-0
4-methyl-benzaldehyde

: 74-89-5
methylamine

: 17972-13-3, 29086-13-3, 53699-34-6
p-methylbenzylidene-methylamine

Conditions

Conditions	Yield
at 20℃; for 12h;	100%
In methanol; dichloromethane for 18h; Molecular sieve;	86%

: 2004-06-0
6-Chloropurine riboside

: 74-89-5
methylamine

: 1867-73-8
N6-methyladenosine

Conditions

Conditions	Yield
With triethylamine In ethanol for 4h; Reflux;	100%
In ethanol; water Sealed tube; Reflux;	94%
In ethanol; water at 100℃; for 72h; Sealed tube;	54%

: 100-52-7
benzaldehyde

: 74-89-5
methylamine

: 622-29-7
N-Benzylidenemethylamine

Conditions

Conditions	Yield
at 20℃; for 12h;	100%
In water for 1h; Ambient temperature;	95%
at 20℃; for 15h;	95%

: 123-08-0
4-hydroxy-benzaldehyde

: 74-89-5
methylamine

: 5766-74-5
4-(Methylimino-methyl)-phenol

Conditions

Conditions	Yield
at 0℃; under 187.515 Torr; Solid phase reaction; gas-solid reaction;	100%
at 20℃; for 12h;	100%
With ethanol; water at 40℃;

: 123-11-5
4-methoxy-benzaldehyde

: 74-89-5
methylamine

: 13114-23-3
4-methoxybenzyl-N-methylimine

Conditions

Conditions	Yield
In ethanol; water at 40℃; for 2h;	100%
In ethanol at 0 - 40℃;	90%
In water for 10h; Ambient temperature;	80%

: 90-02-8
salicylaldehyde

: 74-89-5
methylamine

: 3117-65-5
2-(methyliminomethyl)phenol

Conditions

Conditions	Yield
In ethanol at 20℃; for 8h;	100%
In ethanol at 20℃; for 8h;	100%
With molecular sieve In ethanol; water for 0.5h;	96%

: 1605-65-8
N,N,N',N'-Tetramethylphosphorodiamidic chloride

: 74-89-5
methylamine

: 10159-46-3
Pentamethylphosphoramide

Conditions

Conditions	Yield
at 20℃; for 48h;	100%
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane at 0℃; for 1h;	83%
	64%

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 74-89-5
methylamine

: 17972-14-4
N-(3,4-dimethoxybenzylidene)methanamine

Conditions

Conditions	Yield
With 4 A molecular sieve In toluene at 0℃;	100%
With benzene
In methanol at 40℃; for 5h;
In ethanol at 50℃;
In benzene for 2h; Reflux;

: 100-83-4
meta-hydroxybenzaldehyde

: 74-89-5
methylamine

: 7221-33-2
3-(Methylimino-methyl)-phenol

Conditions

Conditions	Yield
In ethanol at 0 - 5℃; for 2h;	100%
at 20℃; for 12h;	100%
With benzene zuletzt unter Abdestillieren des gebildeten Wassers;

: 556-61-6
methyl thioisocyanate

: 74-89-5
methylamine

: 534-13-4
N,N-dimethylthiourea

Conditions

Conditions	Yield
at 0℃; under 375.03 Torr; Addition; solid-gas reaction;	100%

: 292638-85-8
acrylic acid methyl ester

: 74-89-5
methylamine

: 24549-12-0
methyl 3-(methylamino)propanoate

Conditions

Conditions	Yield
In diethyl ether at 4℃; Addition;	100%
With C12H18NO3S(1+)*HO4S(1-) at 25℃; for 0.0833333h; Ionic liquid; Neat (no solvent); chemoselective reaction;	99%
In ethanol at -10℃;	86%

: 98-86-2
acetophenone

: 74-89-5
methylamine

: 6907-71-7
N-(1-phenylethylidene)methanamine

Conditions

Conditions	Yield
In ethanol at 20℃; for 48h; Molecular sieve; Inert atmosphere;	100%
In ethanol at 20℃; for 48h; Molecular sieve; Inert atmosphere;	100%
With triethylamine In ethanol for 1h; Molecular sieve;	97%

: 591-31-1
3-methoxy-benzaldehyde

: 74-89-5
methylamine

: 16928-30-6
N-(3-methoxybenzylidene)methanamine

Conditions

Conditions	Yield
at 20℃; for 12h;	100%
In ethanol at 0 - 40℃;	90%
In water for 10h; Ambient temperature;	86%

: 135-02-4
ortho-anisaldehyde

: 74-89-5
methylamine

: 1125-90-2
1-(2-methoxyphenyl)-N-methylmethanimine

Conditions

Conditions	Yield
In ethanol at 0 - 40℃;	100%
In water for 10h; Ambient temperature;	80%
With water

: 100-10-7
4-dimethylamino-benzaldehyde

: 74-89-5
methylamine

: 877-79-2
4-(dimethylamino)-N-methylbenzylimine

Conditions

Conditions	Yield
at 20℃; under 750.06 Torr; Solid phase reaction; gas-solid reaction;	100%
at 20℃; for 12h;	100%
With benzene

: 1493-27-2
ortho-nitrofluorobenzene

: 74-89-5
methylamine

: 612-28-2
2-nitro-N-methylaniline

Conditions

Conditions	Yield
In ethanol; water Reflux;	100%
In methanol; water Heating;	98%
In water at 20℃; for 2h; Inert atmosphere;	93%

: 97-00-7
1-chloro-2,4-dinitro-benzene

: 74-89-5
methylamine

: 2044-88-4
N-methyl-2,4-dinitroaniline

Conditions

Conditions	Yield
In ethanol at 20℃; for 15h;	100%
In ethanol; water at 20℃; for 1h;	100%
In ethanol at 0 - 20℃; for 15h;	95%

: 551-06-4
1-isothiocyanatonaphthalene

: 74-89-5
methylamine

: 2740-98-9
1-methyl-3-naphthalene-1-yl-thiourea

Conditions

Conditions	Yield
at 20℃; under 750.06 Torr; Addition; solid-gas reaction;	100%
With ethanol

: 2131-61-5
p-nitrophenyl isothiocyanate

: 74-89-5
methylamine

: 16361-69-6
1-(4-nitrophenyl)-3-methyl-thiourea

Conditions

Conditions	Yield
at 20℃; under 750.06 Torr; Addition; solid-gas reaction;	100%

: 74-89-5
methylamine

: 135-19-3
β-naphthol

: 2216-67-3
2-N-methylaminonaphthalene

Conditions

Conditions	Yield
With ammonium chloride In ethanol at 200℃; for 20h;	100%
With water at 200 - 220℃; unter Druck;
With sodium hydrogensulfite In water Bucherer reaction; Autoclave;

: 74-89-5
methylamine

: 28188-41-2
3-(bromomethyl)benzonitrile

: 90389-96-1
3-((methylamino)methyl)benzonitrile

Conditions

Conditions	Yield
In THjfF (tetrahydrofuran) at 20℃; for 3h; Inert atmosphere;	100%
In tetrahydrofuran at 20℃; for 24h;	96%
In water at 0 - 20℃; for 3.16h;	82%

: 74-89-5
methylamine

: 1985-12-2
4-Bromophenyl isothiocyanate

: 61449-55-6
1-(4-bromophenyl)-3-methyl-thiourea

Conditions

Conditions	Yield
at 20℃; under 750.06 Torr; Addition; solid-gas reaction;	100%
With ethanol

: 74-89-5
methylamine

: 86-51-1
2,3-dimethyoxybenzaldehyde

: 722495-95-6
(2,3-dimethoxy-benzylidene)-methyl-amine

Conditions

Conditions	Yield
at 20℃; for 12h;	100%
In ethanol at 0 - 40℃;	90%
With benzene zuletzt unter Erwaermen und Entfernen des gebildeten Wassers;
In benzene for 2h; Reflux;
In ethanol; water

: 74-89-5
methylamine

: 49845-33-2
2,4-Dichloro-5-nitropyrimidine

: 89283-49-8
2-chloro-4-(methylamino)-5-nitropyrimidine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; methanol at -78 - 20℃; for 3h;	100%
With N-ethyl-N,N-diisopropylamine In dichloromethane at -60℃; for 1h;	85%
With N-ethyl-N,N-diisopropylamine In ethanol; dichloromethane at 0℃; for 0.5h;	85.4%

Methylamine History

Methylamine(74-89-5) was first prepared by Wurtz by the hydrolysis of methylisocyanate and related compounds.

Methylamine Consensus Reports

Reported in EPA TSCA Inventory.

Methylamine Standards and Recommendations

OSHA PEL: TWA 10 ppm
ACGIH TLV: TWA 5 ppm; STEL 15 ppm
DFG MAK: 10 ppm (13 mg/m³)
DOT Classification: 2.3; Label: Poison Gas, Flammable Gas (UN 1061); DOT Class: 3; Label: Flammable Liquid, Corrosive (UN 1235)

Methylamine Analytical Methods

For occupational chemical analysis use OSHA: #40.

Methylamine Specification

The IUPAC name of this chemical is methanamine. With the CAS registry number 74-89-5, it is also named as Aminomethane. The product's categories are Refrigerants; Alkylamines; Biochemistry; Monofunctional & alpha,omega-Bifunctional Alkanes; Monofunctional Alkanes; Reagents for Oligosaccharide Synthesis. It is colourless gas which is soluble in water, ethanol and ether. In addition, it is the simplest primary amine. It is sold as a solution in methanol, ethanol, THF, and water, or as the anhydrous gas in pressurized metal containers. It is flammable by fire and heat. When heated to decomposition it emits toxic fumes of NO_x. So the storage environment should be ventilate, low-temperature and dry.

The other characteristics of Methylamine can be summarized as:
(1)ACD/LogP: -0.66; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.76; (4)ACD/LogD (pH 7.4): -3.54; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 1; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 0; (12)Index of Refraction: 1.34; (13)Molar Refractivity: 10.21 cm³; (14)Molar Volume: 48.7 cm³; (15)Polarizability: 4.05×10^-24 cm³; (16)Surface Tension: 18.4 dyne/cm; (17)Enthalpy of Vaporization: 25.6 kJ/mol; (18)Vapour Pressure: 3970 mmHg at 25°C; (19)Exact Mass: 31.042199; (20)MonoIsotopic Mass: 31.042199; (21)Topological Polar Surface Area: 26; (22)Heavy Atom Count: 2; (23)Complexity: 2.

Preparation of Methylamine:
It can be obtained by many methods. For example: it is produced by the reaction of ammonia with methanol in the presence of a silicoaluminate catalyst. Dimethylamine and trimethylamine are coproduced. CH₃OH + NH₃ → CH₃NH₂ + H₂O
2CH₃OH+NH₃→(CH₃)₂NH+2H₂O
3CH₃OH+NH₃→(CH₃)₃N+3H₂O

Uses of Methylamine:
It is widely used in manufacturing of pharmaceuticals, pesticides, explosives, dyes, photographic developer, vulcanization accelerators, surfactants, preservatives, etc. And it is a good nucleophile as it is highly basic and unhindered, though, as an amine it is considered a weak base. Its use in organic chemistry is pervasive. Liquid methylamine can be used as a solvent analogous to liquid ammonia. Methylamine can also be used for scavenging H₂S from hydrocarbon in refining applications. Furthermore, it is used as a building block for the synthesis of many other commercially available compounds.

When you are using Methylamine, please be cautious about it as the following:
It is extremely flammable and can cause burns, so people should keep it away from sources of ignition. And it is not only toxic by inhalation, in contact with skin and if swallowed, but also irritating to eyes, respiratory system and skin. So it must not empty into drains. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

People can use the following data to convert to the molecule structure.
1. SMILES:NC
2. InChI:InChI=1/CH5N/c1-2/h2H2,1H3
3. InChIKey:BAVYZALUXZFZLV-UHFFFAOYAN

The following are the toxicity data of Methylamine:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LDLo	subcutaneous	200mg/kg (200mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
mammal (species unspecified)	LC50	inhalation	2400mg/m³ (2400mg/m³)		Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 80, 1975.
mouse	LC50	inhalation	2400mg/m³/2H (2400mg/m³)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 81, 1982.
mouse	LDLo	subcutaneous	2500mg/kg (2500mg/kg)		"Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 949, 1989.
rat	LC50	inhalation	448ppm/2.5H (448ppm)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA SKIN AND APPENDAGES (SKIN): "DERMATITIS, IRRITATIVE: AFTER SYSTEMIC EXPOSURE"	Journal of Environmental Biology. Vol. 13, Pg. 273, 1992.
rat	LD50	oral	100mg/kg (100mg/kg)		Inhalation Toxicology. Vol. 2, Pg. 29, 1990.
rat	LDLo	subcutaneous	200mg/kg (200mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.

Product Name

Methylamine

Synthetic route

Methylamine History

Methylamine Consensus Reports

Methylamine Standards and Recommendations

Methylamine Analytical Methods

Methylamine Specification

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