Methylamine hydrochloride supplier

Name
Methylamine hydrochloride
EINECS 209-795-0
CAS No. 593-51-1
Article Data100
CAS DataBase
Density 0.8306 (rough estimate)
Solubility soluble in water
Melting Point 231-233 °C(lit.)
Formula CH₆ClN
Boiling Point 38.2 °C at 760 mmHg
Molecular Weight 67.5183
Flash Point 225-230°C/15mm
Transport Information
Appearance white to light tan solid
Safety 26-37/39
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms Methanamine,hydrochloride (9CI);Methanaminium chloride;Methylamine monohydrochloride;Methylammonium chloride;
PSA 26.02000
LogP 1.07720

Synthetic route

: 920-68-3
heptamethyldisilazane

A: 107-46-0
Hexamethyldisiloxane

B: 593-51-1
methylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride	A n/a B 99%

: 39885-14-8
N-Nitroso-N-methylmethoxymethylamine

: 593-51-1
methylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In methanol for 2h; Heating;	97%

: 115584-91-3
(E)-2-Chloro-3-hydroxy-but-2-enoic acid methyl ester

: 109-89-7
diethylamine

A: 593-51-1
methylamine hydrochloride

B: (E)-2-Chloro-3-hydroxy-but-2-enoic acid methyl ester; compound with diethyl-amine

Conditions

Conditions	Yield
In diethyl ether at -40℃; for 1h;	A n/a B 96%

...Expand

: 650-52-2
bis(trifluoromethyl)chlorophosphine

A: 431-98-1
methylamino-bis-trifluoromethyl-phosphine

B: 593-51-1
methylamine hydrochloride

Conditions

Conditions	Yield
With CH3NH2 In gaseous matrix 0°C;	A 95% B n/a

: 18197-25-6
N-formyl-N-methylformamide

: 593-51-1
methylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water for 168h; Ambient temperature;	94%

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 593-51-1
methylamine hydrochloride

Conditions

Conditions	Yield
Stage #1: formamide With bis(tetrahydrofuran)calcium di(bis(trimethylsilyl)amide); 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In toluene at 120℃; for 36h; Inert atmosphere; Schlenk technique; Stage #2: With hydrogenchloride In diethyl ether; toluene Inert atmosphere; Schlenk technique;	90%
Stage #1: formamide With [(aNHC)KN(SiMe3)2]2; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In toluene at 40℃; for 12h; Inert atmosphere; Glovebox; Schlenk technique; Stage #2: With water; sodium hydroxide In diethyl ether; toluene at 40℃; for 1h; Inert atmosphere; Glovebox; Schlenk technique; Stage #3: With hydrogenchloride In diethyl ether; water Inert atmosphere; Glovebox; Schlenk technique;	98 %Spectr.

: 56-40-6
glycine

: 593-51-1
methylamine hydrochloride

Conditions

Conditions	Yield
Stage #1: glycine With (R)-Carvone In propan-1-ol at 20 - 190℃; under 11251.1 Torr; for 0.216667h; Sealed tube; Microwave irradiation; Stage #2: With hydrogenchloride In propan-1-ol; water at 190℃; for 0.0833333h; Microwave irradiation;	86%

: C11H17N

: 593-51-1
methylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In propan-1-ol at 190℃; for 0.216667h; Temperature; Microwave irradiation; Green chemistry;	86%

: dichloro(nitrosyl)[tris(3,5-dimethylpyrazolyl)-borato]molybdenum

: 74-89-5
methylamine

A: Mo(HB(Me2pyz)3)(NO)Cl(NHMe)

B: 593-51-1
methylamine hydrochloride

Conditions

Conditions	Yield
In ethanol; dichloromethane under N2 soln. Mo(HB(Me2pyz)3)(NO)Cl2 in dichloromethane treated with methylamine (33% ethanolic soln.) and mixt. stirred at room temp. for 30 min; volume solvent reduced in vacuo, Et2O added, (NH3Me)Cl filtered off, filtrate reduced in vacuo; elem. anal.;	A 83% B n/a

...Expand

: 75-52-5
nitromethane

: 593-51-1
methylamine hydrochloride

Conditions

Conditions	Yield
Stage #1: nitromethane With hydrazine hydrate; zinc In methanol at 20℃; for 0.0666667h; Stage #2: With hydrogenchloride	80%
With hydrogenchloride; zinc; hydrazinium monoformate In water for 0.0416667h;	75%
Stage #1: nitromethane With formic acid; nickel In methanol at 20℃; for 0.0833333h; Reduction; Stage #2: With hydrogenchloride Addition;	45%

: 109-89-7
diethylamine

: 115525-64-9
(E)-2-Chloro-4,4-difluoro-3-hydroxy-but-2-enoic acid methyl ester

A: 593-51-1
methylamine hydrochloride

B: 115584-97-9
(E)-2-Chloro-4,4-difluoro-3-hydroxy-but-2-enoic acid methyl ester; compound with diethyl-amine

Conditions

Conditions	Yield
In diethyl ether at -40℃; for 1h;	A n/a B 76%

...Expand

: 74-89-5
methylamine

: 934-16-7
phenylhydroxamoyl chloride

A: 28267-98-3
(Z)-N-Methylbenzamid-oxim

B: 593-51-1
methylamine hydrochloride

Conditions

Conditions	Yield
In diethyl ether for 48h; Ambient temperature;	A 76% B n/a

...Expand

: 74-89-5
methylamine

: 5032-91-7
pentafluorophenyl dichlorophosphine

A: 7542-56-5
C6F5P{N(H)CH3}2

B: 593-51-1
methylamine hydrochloride

Conditions

Conditions	Yield
In diethyl ether byproducts: HCl; in presence of a trap for HCl;	A 75% B n/a
In diethyl ether byproducts: HCl; in presence of a trap for HCl;	A 75% B n/a

...Expand

: 109-89-7
diethylamine

: 115525-65-0
(E)-2-Chloro-4,4,4-trifluoro-3-hydroxy-but-2-enoic acid methyl ester

A: 593-51-1
methylamine hydrochloride

B: 115584-98-0
(E)-2-Chloro-4,4,4-trifluoro-3-hydroxy-but-2-enoic acid methyl ester; compound with diethyl-amine

Conditions

Conditions	Yield
In diethyl ether at -40℃; for 1h;	A n/a B 70%

...Expand

: 109-89-7
diethylamine

: 115525-66-1
(E)-2-Chloro-4,4,5,5,6,6,7,7,7-nonafluoro-3-hydroxy-hept-2-enoic acid methyl ester

A: 593-51-1
methylamine hydrochloride

B: 115584-99-1
(E)-2-Chloro-4,4,5,5,6,6,7,7,7-nonafluoro-3-hydroxy-hept-2-enoic acid methyl ester; compound with diethyl-amine

Conditions

Conditions	Yield
In diethyl ether at -40℃; for 1h;	A n/a B 69%

...Expand

: 78614-25-2
3-Methylcarbamoylsulfanyl-propionic acid methyl ester

A: 870-21-3
3-methylcarbamoylsulfanyl-propionic acid

B: 593-51-1
methylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride Heating;	A 58% B 15%

: 71179-85-6
(CO)5MoP(NHCH3)3

A: 81432-35-1
pentacarbonyl-[chloro-di(methylamino)phosphane]molybdenum(0)

B: 593-51-1
methylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In toluene (N2), HCl introduced into a soln. of the Mo-complex at room temp. for 30 min; removed in vacuo, extd. with hexane, filtered, crystd. at -35°C,elem. anal.;	A 51.2% B >99

: chromium dichloride

A: chromium (III) ion

B: 593-51-1
methylamine hydrochloride

Conditions

Conditions	Yield
With hydrogen cyanide; ammonium chloride In not given in basic soln.; NH4Cl is produced by partial hydrolysis of HCN;	A n/a B 44%
With HCN; NH4Cl In not given in basic soln.; NH4Cl is produced by partial hydrolysis of HCN;	A n/a B 44%

: 75-54-7
Dichloromethylsilane

: 74-89-5
methylamine

A: 593-51-1
methylamine hydrochloride

B: 103873-03-6
1,3-dichloro 1,2,3-trimethyl disilazane

Conditions

Conditions	Yield
In tetrahydrofuran at -30℃; for 15h;	A n/a B 43%

...Expand

: 75-54-7
Dichloromethylsilane

: 74-89-5
methylamine

A: 593-51-1
methylamine hydrochloride

B: 103873-03-6
1,3-dichloro 1,2,3-trimethyl disilazane

C: (1R,5S) and (1S,5R)-1,5-dichloro-1,2,3,4,5-pentamethyltrisilazane

Conditions

Conditions	Yield
In pentane 1.) -30 deg C, 8 h; 2.) RT, 12 h;	A n/a B 39% C 15%

...Expand

: 67-56-1
methanol

: 593-51-1
methylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; copper-salt; ammonium chloride at 370℃; unter Druck;
With hydrogenchloride; iron-salt; ammonium chloride at 370℃; unter Druck;
With copper-salt; ammonium chloride at 370℃; unter Druck;
With iron-salt; ammonium chloride at 370℃; unter Druck;

: 50-00-0
formaldehyd

: 593-51-1
methylamine hydrochloride

Conditions

Conditions	Yield
With water; ammonium chloride
With ammonium chloride at 120 - 210℃;

: 593-81-7
trimethylamine hydrochloride

A: 74-87-3
methylene chloride

B: 593-51-1
methylamine hydrochloride

C: 75-50-3
trimethylamine

Conditions

Conditions	Yield
at 285℃;

...Expand

: 50-98-6
ephedrine hydrochloride

A: 593-51-1
methylamine hydrochloride

B: 93-55-0
1-phenyl-propan-1-one

Conditions

Conditions	Yield
Destillation im CO2-Strom;

: 67-56-1
methanol

: 57-13-6
urea

: 593-51-1
methylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; copper-salt at 370℃; unter Druck;
With hydrogenchloride; iron-salt at 370℃; unter Druck;

: 74-87-3
methylene chloride

: 74-89-5
methylamine

A: 593-51-1
methylamine hydrochloride

B: 75-57-0
tetramethlyammonium chloride

...Expand

: 71-23-8
propan-1-ol

: 703-86-6
2,4,6-trichloro-1,3,5-trimethylborazine

: 71-43-2
benzene

A: 688-71-1
tri-n-propyl borate

B: 593-51-1
methylamine hydrochloride

...Expand

: 50-00-0
formaldehyd

A: 64-18-6
formic acid

B: 3088-27-5
monomethanolamine

C: 593-51-1
methylamine hydrochloride

D: 3684-39-7
N-methylhydroxylamine hydrochloride

Conditions

Conditions	Yield
With ammonium chloride; water at 25℃; for 24h; Further byproducts given;

...Expand

: 50-00-0
formaldehyd

A: 3400-38-2
methylaminomethanol

B: 3088-27-5
monomethanolamine

C: 593-51-1
methylamine hydrochloride

D: 22031-26-1
N-methyldiethanolamine

E: CH5NO*H(1+)

F: 3684-39-7
N-methylhydroxylamine hydrochloride

Conditions

Conditions	Yield
With ammonium chloride In water at 25℃; for 24h; Mechanism;

...Expand

: 124-13-0
Octanal

: 593-51-1
methylamine hydrochloride

: 151-50-8
potassium cyanide

: 112101-12-9
2-Methylamino-nonanenitrile

Conditions

Conditions	Yield
With aluminum oxide In acetonitrile at 50℃; for 22h; ultrasound;	100%

...Expand

: 2011-06-5
2-benzyloxy-3-methoxybenzaldehyde

: 593-51-1
methylamine hydrochloride

: 88741-41-7
1-(2-(benzyloxy)-3-methoxyphenyl)-N-methylmethanamine

Conditions

Conditions	Yield
With sodium tetrahydroborate	100%

: 593-51-1
methylamine hydrochloride

: 149967-29-3
N-[(R)-1-[(1,1-dimethylethoxy)carbonyl]-3-(1,3-dihydro-1,3-dioxo-2H-benz[f]isoindol-2-yl)propyl]-L-leucine

: 154296-26-1
N-<1-(R)-<(1,1-dimethylethoxy)carbonyl>-3-(1,3-dihydro-1,3-dioxo-2H-benzisoindol-2-yl)propyl>-N'-methyl-L-leucinamide

Conditions

Conditions	Yield
With 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide In dichloromethane for 18h; Ambient temperature;	100%

: 593-51-1
methylamine hydrochloride

: 2004-06-0
6-Chloropurine riboside

: 1867-73-8
N6-methyladenosine

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide for 72h;	100%

: 593-51-1
methylamine hydrochloride

: 151-50-8
potassium cyanide

: 98-86-2
acetophenone

: 112101-15-2
2-methylamino-2-phenyl-propionitrile

Conditions

Conditions	Yield
With aluminum oxide In acetonitrile at 50℃; for 24h; ultrasound;	100%

...Expand

: 623950-04-9
4'-carboxyl N-Boc-2',6'-dimethyl-L-phenylalanine methyl ester

: 593-51-1
methylamine hydrochloride

: 861676-19-9
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(2,6-dimethyl-4-(methylcarbamoyl)phenyl)propanoate

Conditions

Conditions	Yield
With ammonium chloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide; tert-butyl alcohol at 20℃; for 0.666667h;	100%

: 593-51-1
methylamine hydrochloride

: 126093-01-4
methyl 4-<<<4-<<<4-<<(tert-butyloxy)carbonyl>amino>-1-methyl-pyrrol-2-yl>carbonyl>amino>-1-methyl-pyrrol-2-yl>carbonyl>amino>-1-methyl-pyrrole-2-carboxylic acid

: {1-methyl-5-[1-methyl-5-(1-methyl-5-methylcarbamoyl-1H-pyrrol-3-ylcarbamoyl)-1H-pyrrol-3-ylcarbamoyl]-1H-pyrrol-3-yl}-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 14h;	100%

: 593-51-1
methylamine hydrochloride

: 1009303-67-6
5-bromo-2-difluoromethoxy-N-methyl-benzamide

Conditions

Conditions	Yield
Stage #1: 5-bromo-2-difluoromethoxy-benzoic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: methylamine hydrochloride In N,N-dimethyl-formamide at 20℃; for 2h;	100%

: 621685-61-8
C16H16N4O3

: 593-51-1
methylamine hydrochloride

: 621685-62-9
C17H19N5O2

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In DMF (N,N-dimethyl-formamide) at 20℃;	100%

: 369-34-6
3,4-difluoronitrobenzene

: 593-51-1
methylamine hydrochloride

: 124431-92-1
N-methyl-2-fluoro-4-nitroaniline

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 24h;	100%

: 5081-36-7
3-methoxy-4-nitrobenzoic acid

: 593-51-1
methylamine hydrochloride

: 878160-13-5
3-methoxy-N-methyl-4-nitrobenzamide

Conditions

Conditions	Yield
Stage #1: 3-methoxy-4-nitrobenzoic acid; methylamine hydrochloride With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.0833333h; Stage #2: With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h;	100%
With benzotriazol-1-ol In N,N-dimethyl-formamide at 20℃; for 18h;

: 593-51-1
methylamine hydrochloride

: 111-64-8
n-octanoic acid chloride

: 1119-57-9
N-methyloctanoylamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 5℃; for 2.5h;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 3h;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 3h;	100%

: 881673-82-1
5-bromo-1-(phenylsulfonyl)-1H-pyrrole-3-carbaldehyde

: 593-51-1
methylamine hydrochloride

: 881673-83-2
1-[5-bromo-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine

Conditions

Conditions	Yield
With sodium cyanoborohydride In methanol at 20℃; for 1h;	100%
With methanol; sodium cyanoborohydride at 20℃; for 1h;	100%
With methanol; sodium cyanoborohydride at 10 - 35℃; for 1h;	100%

: 915037-54-6
4-(5-nitro-1H-indol-3-yl)cyclohex-3-enone

: 593-51-1
methylamine hydrochloride

: 915037-55-7
N-methyl-4-(5-nitro-1H-indol-3-yl)cyclohex-3-enamine

Conditions

Conditions	Yield
Stage #1: 4-(5-nitro-1H-indol-3-yl)cyclohex-3-enone; methylamine hydrochloride With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; for 14h; Stage #2: With sodium hydroxide In water; 1,2-dichloro-ethane	100%
Stage #1: 4-(5-nitro-1H-indol-3-yl)cyclohex-3-enone; methylamine hydrochloride With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; for 14h; Stage #2: With sodium hydroxide In water; 1,2-dichloro-ethane	100%
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; for 14h; Inert atmosphere;	54%

: 15761-38-3
L-N-Boc-Ala

: 593-51-1
methylamine hydrochloride

: 84851-00-3
tert-butyl N-[(1S)-1-(methylcarbamoyl)ethyl]carbamate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 17.5h;	100%
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In acetonitrile at 25℃; for 10h;	68%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0 - 20℃;	50%
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine In dichloromethane at 23℃; for 12h;
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 2h;

: 593-51-1
methylamine hydrochloride

: 126832-81-3
1-(pyridin-4-yl)-4-oxopiperidine

: 392330-66-4
N-methyl-1-(pyridin-4-yl)piperidin-4-amine

Conditions

Conditions	Yield
With sodium cyanoborohydride In methanol at 20℃; for 17h;	100%
Stage #1: methylamine hydrochloride; 1-(pyridin-4-yl)-4-oxopiperidine; acetic acid In methanol at 20℃; for 0.333333h; Stage #2: With sodium cyanoborohydride In methanol at 20℃; for 16h;

: 593-51-1
methylamine hydrochloride

: 171348-52-0
2-((tert-butoxycarbonyl)amino)-3-fluoro-3-methylbutanoic acid

: 171348-53-1
tert-butyl 3-fluoro-3-methyl-1-(methylamino)-1-oxobutan-2-ylcarbamate

Conditions

Conditions	Yield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine In dichloromethane for 18h;	100%

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 593-51-1
methylamine hydrochloride

: 405057-75-2
4-methylamino-piperidine-1-carboxylic acid benzyl ester

Conditions

Conditions	Yield
Stage #1: benzyl 4-oxo-1-piperidinecarboxylate; methylamine hydrochloride With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; Stage #2: With sodium hydrogencarbonate In water; 1,2-dichloro-ethane	100%

: potassium cyanide

: 40320-60-3
N-benzhydryl 3-azetidinone

: 593-51-1
methylamine hydrochloride

: 1-Benzhydryl-3-methylaminoazetidine-3-carbonitrile

Conditions

Conditions	Yield
Stage #1: N-benzhydryl 3-azetidinone; methylamine hydrochloride With acetic acid In methanol at 20℃; for 0.0833333h; Stage #2: potassium cyanide at 60℃; for 19h;	100%
Stage #1: N-benzhydryl 3-azetidinone; methylamine hydrochloride With acetic acid In methanol at 20℃; for 0.0833333h; Stage #2: potassium cyanide at 60℃; for 19h;	100%
Stage #1: N-benzhydryl 3-azetidinone; methylamine hydrochloride With acetic acid In methanol at 20℃; for 0.0833333h; Stage #2: potassium cyanide In methanol at 60℃; for 19h;	100%

...Expand

: 876-08-4
p-(chloromethyl)benzoyl chloride

: 593-51-1
methylamine hydrochloride

: 220875-88-7
4-(chloromethyl)-N-methylbenzamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 1h;	100%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;

: 1177420-61-9
3-Fluoro-4-{3-[(1S)-2-methoxy-1-methylethoxy]-5-[5-(1,3-thiazol-2-yl)-1H-pyrrol-2-yl]phenoxy}benzoic acid

: 593-51-1
methylamine hydrochloride

: 1177418-90-4
3-fluoro-4-{3-[(1S)-2-methoxy-1-methylethoxy]-5-[5-(1,3-thiazol-2-yl)-1H-pyrrol-2-yl]phenoxy}-N-methylbenzamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In tetrahydrofuran at 20℃; for 4h; Inert atmosphere;	100%

: 1567687-33-5
2-((2R,3R,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)acetic acid

: 593-51-1
methylamine hydrochloride

: 1567688-08-7
(2R,3R,4R,5R)-tert-butyl 3,4-bis(benzyloxy)-2-((benzyloxy)methyl)-5-(2-(methylamino)-2-oxoethyl)pyrrolidine-1-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 48h;	100%

: 1613515-91-5
1-(5-bromopentyl)-5-fluoro-3-iodo-1H-indazole

: 593-51-1
methylamine hydrochloride

: 1613516-39-4
5-(5-fluoro-3-iodo-1H-indazol-1-yl)-N-methylpentan-1-amine

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In tetrahydrofuran at 90℃; Sealed tube;	100%

: 593-51-1
methylamine hydrochloride

: 6404-31-5
Z-D-proline

: 66877-06-3
benzyl (2R)-2-(methylcarbamoyl)pyrrolidine-1-carboxylate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0 - 25℃; for 7h;	100%

: quartz

: 593-51-1
methylamine hydrochloride

: lead(II) chloride

Reaxys ID: 28470677: Reaxys ID: 28470677

Conditions

Conditions	Yield
In dichloromethane; N,N-dimethyl-formamide	100%

...Expand

: quartz

: 593-51-1
methylamine hydrochloride

: lead(II) bromide

: 6876-37-5
methylammonium bromide

: lead(II) chloride

Reaxys ID: 28470674: Reaxys ID: 28470674

Conditions

Conditions	Yield
In dichloromethane; N,N-dimethyl-formamide	100%

...Expand

: (R)-tert-butyl 3-(5-iodo-2-(methoxycarbonyl)phenoxy)pyrrolidine-1-carboxylate

: 593-51-1
methylamine hydrochloride

: (R)-tert-butyl 3-(5-iodo-2-(methylcarbamoyl)phenoxy)pyrrolidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: (R)-tert-butyl 3-(5-iodo-2-(methoxycarbonyl)phenoxy)pyrrolidine-1-carboxylate With sodium hydroxide In tetrahydrofuran; methanol at 25℃; for 2h; Stage #2: methylamine hydrochloride With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In tetrahydrofuran; methanol for 2h;	100%

: 593-51-1
methylamine hydrochloride

: 530-62-1
1,1'-carbonyldiimidazole

: 72002-25-6
imidazole-1-carboxylic acid N-methylamide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide; acetonitrile at 20℃; for 2h;	100%
In N,N-dimethyl-formamide; acetonitrile at 20℃; for 2h;	75%
In N,N-dimethyl-formamide; acetonitrile at 20℃; for 2h;	68%
In N,N-dimethyl-formamide; acetonitrile at 20℃; for 3.25h;	57%
In N,N-dimethyl-formamide; acetonitrile at 20℃;	9.87 g

: C18H17N3O4

: 593-51-1
methylamine hydrochloride

: C19H20N4O3

Conditions

Conditions	Yield
With 1-hydroxy-7-aza-benzotriazole; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;	100%

: 10-bromo-2-carbamoyl-9-fluoro-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-3-carboxylic acid

: 593-51-1
methylamine hydrochloride

: 10-bromo-9-fluoro-N3-methyl-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2,3-dicarboxamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In tetrahydrofuran	100%

Methylamine hydrochloride Specification

The IUPAC name of this chemical is Methanamine,hydrochloride. With the CAS registry number 593-51-1 and EINECS registry number 209-795-0, it is also named as methanaminium chloride. In addition, the molecular formula is CH₆ClN. It is a kind of white to light tan solid and incompatible with strong oxidizing agents. And it may be sensitive with moisture. In addition, it can be used as a reagent for the analysis and used for organic synthesis.

Physical properties about Methylamine hydrochloride are:
(1)ACD/LogP: -0.66; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.76; (4)ACD/LogD (pH 7.4): -3.54; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 1; (10)#H bond donors: 2; (11)Enthalpy of Vaporization: 25.6 kJ/mol; (12)Boiling Point: 38.2 °C at 760 mmHg; (13)Vapour Pressure: 3970 mmHg at 25°C.

Preparation of Methylamine hydrochloride:
It can be prepared by carboamine solution. Add the hydrochloric acid into the carboamine solution. The pH value should be controlled at 2-3. And then after a series of decoloring, filtration, concentration and crystallization you can get the desired product. The equation is as follows:

Uses of Methylamine hydrochloride:
It can be used to get methylsulfamoyl chloride. This reaction will need reagent SO₂Cl₂, catalyst SbCl₅ and solvent acetonitrile. The yield is about 66%.
Methanamine,hydrochloride (1:1) can be used to get methylsulfamoyl chloride

Safety information of Methylamine hydrochloride:
When you are using Methylamine hydrochloride, please be cautious about it as the following:This chemical is harmful if swallowed. It is irritating to eyes, respiratory system and skin. Whenever you will contact it, please wear gloves and eye/face protection. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: [Cl-].[NH3+]C
(2)InChI: InChI=1/CH5N.ClH/c1-2;/h2H2,1H3;1H
(3)InChIKey: NQMRYBIKMRVZLB-UHFFFAOYAJ

The toxicity data of Methylamine hydrochloride is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
guinea pig	LD50	skin	> 2gm/kg (2000mg/kg)	Kodak Company Reports. Vol. 21MAY1971,
mouse	LD50	intraperitoneal	2160mg/kg (2160mg/kg)	Yakugaku Zasshi. Journal of Pharmacy. Vol. 97, Pg. 1117, 1977.
rat	LD50	oral	1600mg/kg (1600mg/kg)	Inhalation Toxicology. Vol. 2, Pg. 29, 1990.

Product Name

Methylamine hydrochloride

Synthetic route

Methylamine hydrochloride Specification

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