Conditions | Yield |
---|---|
With C6H5N(CH3)2; CH3OH reaction in presence of Dimethylphenyl amine:; | 90% |
With methanol; N,N-dimethyl-aniline reaction in presence of Dimethylphenyl amine:; | 90% |
With C5H5N; CH3OH reaction in presence of pyridine;; |
Conditions | Yield |
---|---|
at 35℃; for 7h; Temperature; Inert atmosphere; Large scale; | 80.2% |
Conditions | Yield |
---|---|
bismuth(III) chloride at 25℃; for 15h; Inert atmosphere; | 59% |
(chloromethyl)trimethoxysilane
A
Methyltrimethoxysilan
B
1,1,3,3,5,5-hexamethoxy-1,3,5-trisilacyclohexane
Conditions | Yield |
---|---|
With magnesium In tetrahydrofuran at -20 - 0℃; | A 0.5% B 45% C 20% |
Dimethoxymethane
tris(ethylthio)methylsilane
A
Methyltrimethoxysilan
B
(ethylthio)methoxymethane
Conditions | Yield |
---|---|
With zinc(II) chloride In toluene at 0℃; for 5h; Product distribution; other temperature; | A 4% B 10% |
With zinc(II) chloride In toluene at 0℃; for 5h; | A 4% B 10% |
Methyltrichlorosilane
A
Methyltrimethoxysilan
B
1,3-dimethyltetramethoxydisiloxane
C
1,1,3,5,5-pentamethoxy-1,3,5-trimethyl-trisiloxane
D
1,1,3,5,7,7-hexamethoxy-1,3,5,7-tetramethyl-tetrasiloxane
Conditions | Yield |
---|---|
With CH3OH | A n/a B n/a C 9.6% D 5.6% |
With CH3OH | A n/a B n/a C 9.6% D 5.6% |
1,1,2,2-tetramethoxy-1,2-dimethyl-disilane
Methyltrimethoxysilan
Conditions | Yield |
---|---|
(basic elimination); |
Methoxytrimethylsilane
methyltrifluorosilane
methylfluorodimethoxysilane
methyldifluoromethoxysilane
A
trimethylsilyl fluoride
B
Methyltrimethoxysilan
Conditions | Yield |
---|---|
at 120℃; Equilibrium constant; |
Methoxytrimethylsilane
methyltrifluorosilane
A
trimethylsilyl fluoride
B
Methyltrimethoxysilan
C
methylfluorodimethoxysilane
D
methyldifluoromethoxysilane
Conditions | Yield |
---|---|
at 120℃; Equilibrium constant; |
methyltrifluorosilane
dimethyldimethoxysilan
methoxydimethylfluorosilane
methylfluorodimethoxysilane
methyldifluoromethoxysilane
A
dimethyldifluorosilane
B
Methyltrimethoxysilan
Conditions | Yield |
---|---|
at 120℃; Equilibrium constant; |
methyltrifluorosilane
dimethyldimethoxysilan
A
dimethyldifluorosilane
B
Methyltrimethoxysilan
C
methoxydimethylfluorosilane
D
methylfluorodimethoxysilane
E
methyldifluoromethoxysilane
Conditions | Yield |
---|---|
at 120℃; Equilibrium constant; |
methanol
Methyltriethoxysilan
A
ethanol
B
Methyltrimethoxysilan
C
C6H16O3Si
Conditions | Yield |
---|---|
With sodium at 21.9℃; Rate constant; |
methanol
silicon
A
trimethoxysilane
B
tetramethylorthosilicate
C
dimethyldimethoxysilan
D
Methyltrimethoxysilan
Conditions | Yield |
---|---|
With sodium chloride at 150 - 200℃; Product distribution / selectivity; | |
With sodium chloride; copper(l) chloride at 150℃; Product distribution / selectivity; |
methanol
silicon
A
tetramethylorthosilicate
B
dimethyldimethoxysilan
C
Methyltrimethoxysilan
Conditions | Yield |
---|---|
With sodium chloride at 30 - 350℃; for 1.5 - 4.5h; Product distribution / selectivity; | |
With sodium chloride; copper(l) chloride at 200 - 300℃; for 3h; Product distribution / selectivity; |
methanol
A
trimethoxysilane
B
tetramethylorthosilicate
C
dimethyldimethoxysilan
D
Methyltrimethoxysilan
Conditions | Yield |
---|---|
With sodium chloride; copper(l) chloride at 150 - 320℃; Product distribution / selectivity; |
methanol
A
tetramethylorthosilicate
B
dimethyldimethoxysilan
C
Methyltrimethoxysilan
Conditions | Yield |
---|---|
With sodium chloride at 260℃; Product distribution / selectivity; |
Conditions | Yield |
---|---|
With sodium chloride at 320℃; Product distribution / selectivity; |
N-methyl-4-chlorophthalimide
B
Methyltrimethoxysilan
Conditions | Yield |
---|---|
In tetrakis(triphenylphosphine) palladium(0) |
methanol
silicon
A
trimethoxysilane
B
tetramethylorthosilicate
C
Methyltrimethoxysilan
D
(dimethoxy)methylsilane
Conditions | Yield |
---|---|
copper(II) orthophosphate In THERMINOL 59 at 250℃; Product distribution / selectivity; | |
copper(II) hydroxide; sodium phosphate In THERMINOL 59 at 250℃; Product distribution / selectivity; | |
copper(II) orthophosphate; copper(II) hydroxide In THERMINOL 59 at 250℃; Product distribution / selectivity; |
tetramethylorthosilicate
methyllithium
A
dimethyldimethoxysilan
B
Methyltrimethoxysilan
Conditions | Yield |
---|---|
Stage #1: methyllithium With copper(l) iodide In diethyl ether at 0℃; for 1.16h; Schlenk technique; Stage #2: tetramethylorthosilicate In diethyl ether at 0 - 23℃; for 2.16h; Schlenk technique; |
methanol
A
trimethoxysilane
B
tetramethylorthosilicate
C
Methyltrimethoxysilan
Conditions | Yield |
---|---|
With amorphous silicon at 200℃; Temperature; Inert atmosphere; Schlenk technique; |
methanol
A
trimethoxysilane
B
tetramethylorthosilicate
C
dimethyldimethoxysilan
D
Methyltrimethoxysilan
Conditions | Yield |
---|---|
With amorphous silicon In paraffin oil at -196 - 150℃; Reagent/catalyst; Sealed tube; Inert atmosphere; Schlenk technique; |
Conditions | Yield |
---|---|
With amorphous silicon In paraffin oil at 300℃; Temperature; Reagent/catalyst; Inert atmosphere; Schlenk technique; |
methanol
A
tetramethylorthosilicate
B
dimethyldimethoxysilan
C
Methyltrimethoxysilan
Conditions | Yield |
---|---|
With copper(l) chloride In paraffin oil at 300℃; Temperature; Inert atmosphere; Schlenk technique; |
Conditions | Yield |
---|---|
With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); tetrabutyl ammonium fluoride In tetrahydrofuran at 60℃; for 0.5h; Hiyama coupling; Inert atmosphere; | 100% |
With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); tetrabutyl ammonium fluoride In tetrahydrofuran at 60℃; for 0.5h; | 82% |
Conditions | Yield |
---|---|
In benzene-d6 at 60℃; for 1h; Temperature; Inert atmosphere; | 100% |
Methyltrichlorosilane
Methyltrimethoxysilan
chlorobenzene
dimethoxy(methyl)phenylsilane
Conditions | Yield |
---|---|
Stage #1: Methyltrimethoxysilan; chlorobenzene With magnesium In tetrahydrofuran for 1h; Reflux; Stage #2: Methyltrichlorosilane; Methyltrimethoxysilan; chlorobenzene In tetrahydrofuran for 6.5h; Concentration; Reflux; | 99.6% |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide; acetonitrile at 100℃; Inert atmosphere; | 99.4% |
Conditions | Yield |
---|---|
With fluorosulfonyl fluoride In chlorobenzene at 20℃; for 12h; Solvent; Sealed tube; | 99% |
With fluorosulfonyl fluoride In tetrahydrofuran at 23 - 27℃; for 12h; | 99% |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid at 85 - 153℃; for 7h; Temperature; | 98.3% |
Methyltrimethoxysilan
Conditions | Yield |
---|---|
With potassium chloride; water; acetic acid at 38℃; for 2.5h; Temperature; Reagent/catalyst; | 98.3% |
Conditions | Yield |
---|---|
With fluorosulfonyl fluoride In chlorobenzene at 20℃; for 12h; Solvent; Sealed tube; | 98% |
Conditions | Yield |
---|---|
With sodium hydroxide In N,N-dimethyl-formamide; acetonitrile at 100℃; Inert atmosphere; | 97.6% |
Conditions | Yield |
---|---|
In ethanol; water for 240h; | 97% |
Conditions | Yield |
---|---|
With fluorosulfonyl fluoride In chlorobenzene at 20℃; for 12h; Solvent; Sealed tube; | 97% |
With fluorosulfonyl fluoride In chlorobenzene at 23 - 27℃; for 12h; | 97% |
Conditions | Yield |
---|---|
Stage #1: Hexamethyldisiloxane With oxygen-containing linear phosphazene chloride In dichloromethane; isopropyl alcohol at 10℃; for 1.66667h; Stage #2: Methyltrimethoxysilan In dichloromethane; water; isopropyl alcohol at 5 - 25℃; for 12h; Temperature; Reagent/catalyst; | 96.9% |
Stage #1: Hexamethyldisiloxane With methanol; sulfuric acid at -10 - 10℃; for 0.75 - 1h; Stage #2: Methyltrimethoxysilan at 5 - 10℃; for 0.5 - 1.75h; Stage #3: With water at 5 - 25℃; for 4h; | 88.1% |
Stage #1: Hexamethyldisiloxane With ethanol; trifluorormethanesulfonic acid at -10 - 10℃; for 0.833333h; Stage #2: Methyltrimethoxysilan at 5 - 10℃; for 1.5h; Stage #3: With water at 5 - 25℃; for 5h; | 88% |
Methyltrimethoxysilan
1-oxo-1-methyl-4-ethyl-4-hydroxymethyl-2,6-dioxa-1-phosphacyclohexane
Conditions | Yield |
---|---|
In diethylene glycol dimethyl ether at 100℃; for 8h; Solvent; Temperature; Inert atmosphere; | 95.5% |
Methyltrimethoxysilan
phenylmagnesium bromide
dimethoxy(methyl)phenylsilane
Conditions | Yield |
---|---|
In diethyl ether for 1h; Reflux; | 95% |
Conditions | Yield |
---|---|
With fluorosulfonyl fluoride In chlorobenzene at 20℃; for 12h; Solvent; Sealed tube; | 95% |
Conditions | Yield |
---|---|
With dimethyl sulfate at 102 - 150℃; for 13h; Concentration; Temperature; Reagent/catalyst; Solvent; Inert atmosphere; | 94.5% |
Conditions | Yield |
---|---|
With hydrogenchloride at 65℃; | 94% |
Methyltrimethoxysilan
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 24h; Solvent; Temperature; Inert atmosphere; | 94% |
Methyltrimethoxysilan
Conditions | Yield |
---|---|
With methoxybenzene at 100 - 150℃; for 16h; Temperature; | 93.6% |
Conditions | Yield |
---|---|
With magnesium; potassium iodide for 4.5h; Reflux; Inert atmosphere; | 92.75% |
Methyltrimethoxysilan
4-(hydroxymethyl)-1-oxido-2,6,7-trioxa-1-phosphabicyclo [2.2.2] octane
Conditions | Yield |
---|---|
In 1,4-dioxane at 100℃; for 7h; Solvent; Temperature; Inert atmosphere; | 92.7% |
Conditions | Yield |
---|---|
Stage #1: Isobutyl bromide With magnesium; methyl iodide In tetrahydrofuran for 0.1h; Inert atmosphere; Reflux; Large scale; Stage #2: Methyltrimethoxysilan In tetrahydrofuran at 89℃; for 4.2h; Temperature; Inert atmosphere; Large scale; | 92.3% |
Methyltrimethoxysilan
Hexamethyldisiloxane
A
methyltrimethicone
B
1,1,1,3,5,5,5-heptamethyl-3-methoxytrisiloxane
C
1,1,1,3,5,5,5-heptamethyltrisiloxan-3-ole
Conditions | Yield |
---|---|
Stage #1: Hexamethyldisiloxane With methanol; sulfuric acid at 5 - 10℃; for 1h; Stage #2: Methyltrimethoxysilan at 5 - 10℃; for 1.5 - 1.75h; Stage #3: With sulfuric acid; water Product distribution / selectivity; more than 3 stages; | A 91.5% B n/a C n/a |
Stage #1: Hexamethyldisiloxane With methanol; sulfuric acid at 5 - 10℃; for 1h; Stage #2: Methyltrimethoxysilan at 5 - 10℃; for 1.5h; Stage #3: With hydrogenchloride; water Product distribution / selectivity; more than 3 stages; | A 91% B n/a C n/a |
Conditions | Yield |
---|---|
Stage #1: bromobenzene With magnesium; methyl iodide In tetrahydrofuran for 0.1h; Inert atmosphere; Reflux; Large scale; Stage #2: Methyltrimethoxysilan In tetrahydrofuran at 90℃; for 6.3h; Inert atmosphere; Large scale; | 90.2% |
With sodium at 38℃; for 2h; Temperature; Reagent/catalyst; | 80% |
Methyltrimethoxysilan
benzene-1,2-diol
sodium bis(1,2-benzenediolato)methylsilicate
Conditions | Yield |
---|---|
With sodium methylate In methanol at 45℃; for 4h; | 90% |
Conditions | Yield |
---|---|
With iron(III) chloride at 90℃; for 0.75h; polycondensation; | 89% |
Methyltrimethoxysilan
[RuCl2(NC5H4C5H4N)((CH3CH2O)3Si(CH2)3NHC(O)NHCH2C6H4P(C6H5)CH2CH2OCH3)2]
Conditions | Yield |
---|---|
With water; dibutyltin diacetate In tetrahydrofuran; methanol calcd. amt. of Si compd., H2O and (n-Bu)2Sn(OAc)2 added to soln. of Ru complex in MeOH/THF (1:3), stirred for 3 d at room temp.; pptd. gel washed with toluene, Et2O and petroleum ether (40-70), xerogelgrinded and dried under vac. for 24 h, elem. anal.; | 89% |
Conditions | Yield |
---|---|
With potassium hexamethylsilazane In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; | 89% |
Methyltrimethoxysilan
6-(9H-fluorenyl)hexyltrimethoxysilane
Conditions | Yield |
---|---|
With ammonia In methanol; water at 30℃; for 12h; | 88.2% |
Reported in EPA TSCA Inventory.
The Methyltrimethoxysilane, with the CAS registry number 1185-55-3, is also known as Trimethoxy(methyl)silane. It belongs to the product categories of Organosilicon;Self Assembly &;Silane Coupling Agents/Adhesion Promoters.This chemical's molecular formula is C4H12O3Si and molecular weight is 136.22.Its EINECS number is 214-685-0. What's more,Its systematic name is Trimethoxy(methyl)silane.It is a colorless clear liquid.And it is stable,but moisture sensitive, highly flammable,incompatible with water, strong acids, strong oxidizing agents.It is highly Flammable,when you use it ,keep away from sources of ignition-No smoking.
Physical properties about Methyltrimethoxysilane are:
(1)ACD/LogP: 1.653; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.65; (4)ACD/LogD (pH 7.4): 1.65; (5)ACD/BCF (pH 5.5): 10.62; (6)ACD/BCF (pH 7.4): 10.62; (7)ACD/KOC (pH 5.5): 188.84; (8)ACD/KOC (pH 7.4): 188.84; (9)#H bond acceptors: 3; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 3; (12)Index of Refraction: 1.379; (13)Molar Refractivity: 34.533 cm3; (14)Molar Volume: 149.386 cm3; (15)Surface Tension: 18.4139995574951 dyne/cm; (16)Density: 0.912 g/cm3; (17)Flash Point: 11.111 °C; (18)Enthalpy of Vaporization: 32.75 kJ/mol; (19)Boiling Point: 102.499 °C at 760 mmHg; (20)Vapour Pressure: 38.8209991455078 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)(1)SMILES:O(C)[Si](OC)(OC)C;
(2)Std. InChI:InChI=1S/C4H12O3Si/c1-5-8(4,6-2)7-3/h1-4H3;
(3)Std. InChIKey:BFXIKLCIZHOAAZ-UHFFFAOYSA-N.
The toxicity data of Methyltrimethoxysilane as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
rabbit | LD | skin | > 10mL/kg (10mL/kg) | Union Carbide Data Sheet. Vol. 1/17/1972, | |
rat | LD50 | oral | 12300uL/kg (12.3mL/kg) | Union Carbide Data Sheet. Vol. 1/17/1972, |
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