N-(2-Hydroxyethyl)piperazine supplier

Name
N-(2-Hydroxyethyl)piperazine
EINECS 203-142-3
CAS No. 103-76-4
Article Data55
CAS DataBase
Density 1.012 g/cm³
Solubility Miscible with water
Melting Point -38.5 °C
Formula C₆H₁₄N₂O
Boiling Point 245 °C at 760 mmHg
Molecular Weight 130.19
Flash Point 101.9 °C
Transport Information
Appearance Clear colorless to pale yellow oily liquid
Safety 26-36/37/39
Risk Codes 36/37/38-41
Molecular Structure
Hazard Symbols Xi
Synonyms (b-Hydroxyethyl)piperazine;1-(2-Hydroxyethyl)piperazine;1-(b-Hydroxyethyl)piperazine;2-(1-Piperazinyl)ethanol;2-(Piperazin-1-yl)ethanol;2-Piperazinoethanol;N-(2-Hydroxyethyl)piperazine;N-(2'-Hydroxyethyl)piperazine;N-(b-Hydroxyethyl)piperazine;NSC 26884;NSC 38969;NSC 60706;
PSA 35.50000
LogP -0.84940

Synthetic route

: 161742-25-2
4-[(3-methyl-2-butenyl)oxycarbonyl]-1-(2-hydroxyethyl)piperazine

: 103-76-4
1-(2-hydroxyethyl)piperazine

Conditions

Conditions	Yield
With diethylamine; Pd(0) (in situ from Pd(OAc)2 and m.sulfonated triphenylphosphine) In water; acetonitrile for 0.25h; 5 molpercent catalyst;	100%

: 27612-67-5
2-(4-allyl-piperazin-1-yl)-ethanol

: 103-76-4
1-(2-hydroxyethyl)piperazine

Conditions

Conditions	Yield
With Thiosalicylic acid; 1,4-di(diphenylphosphino)-butane; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran at 20℃; for 0.5h;	100%

: 75-21-8
oxirane

: 110-85-0
piperazine

: 103-76-4
1-(2-hydroxyethyl)piperazine

Conditions

Conditions	Yield
In various solvent(s) at 40℃; for 0.5h;	95%
In water at 15 - 35℃; for 2h; Temperature;	81.7%

: 141-43-5
ethanolamine

: 334-22-5
N,N-bis(chloro-2-ethyl)amine

: 103-76-4
1-(2-hydroxyethyl)piperazine

Conditions

Conditions	Yield
With potassium carbonate In water at 83℃; for 5h; Temperature;	94%

: 110-85-0
piperazine

: 141-46-8
Glycolaldehyde

: 103-76-4
1-(2-hydroxyethyl)piperazine

Conditions

Conditions	Yield
With manganese; chromium; hydrogen; nickel; aluminium In water at 150℃; under 22502.3 Torr; Temperature; Pressure; Reagent/catalyst; Solvent; Autoclave;	92.3%

: 23936-04-1
4-(2-hydroxyethyl)-2-piperazinone

: 103-76-4
1-(2-hydroxyethyl)piperazine

Conditions

Conditions	Yield
With ammonia at 40℃; under 1500.15 Torr; for 2.5h;	88%

: 110-85-0
piperazine

: 540-51-2
2-bromoethanol

A: 103-76-4
1-(2-hydroxyethyl)piperazine

B: 122-96-3
1,4-bis(2-hydroxyethyl)piperazine

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water for 2.5h; pH=8.5; pH-value; Reagent/catalyst; Inert atmosphere;	A 86.2% B n/a

...Expand

: 150479-63-3
8-methyl-2-(2-n-propoxyphenyl)quinazolin-4(3H)-one

A: 103-76-4
1-(2-hydroxyethyl)piperazine

B: 2-{5-[4-(2-hydroxyethyl)-1-piperazinylsulphonyl]-2-n-propoxyphenyl}-8-methylquinazolin-4(3H)-one

Conditions

Conditions	Yield
	A n/a B 84%

: 64055-53-4
2-[2-(ethyloxy)phenyl]quinazoline-4(3H)-one

A: 103-76-4
1-(2-hydroxyethyl)piperazine

B: 150479-46-2
2-{2-Ethoxy-5-[4-(2-hydroxyethyl)-1-piperazinyl-sulphonyl]phenyl}quinazolin-4(3H)-one

Conditions

Conditions	Yield
	A n/a B 78%

: 64055-53-4
2-[2-(ethyloxy)phenyl]quinazoline-4(3H)-one

A: 103-76-4
1-(2-hydroxyethyl)piperazine

B: 150479-46-2
2-{2-Ethoxy-5-[4-(2-hydroxyethyl)-1-piperazinylsulphonyl]phenyl}quinazolin-4(3)-one

Conditions

Conditions	Yield
	A n/a B 78%

: 141-43-5
ethanolamine

A: 103-76-4
1-(2-hydroxyethyl)piperazine

B: 122-96-3
1,4-bis(2-hydroxyethyl)piperazine

Conditions

Conditions	Yield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium hydrogencarbonate In water at 140℃; for 96h; Inert atmosphere; Heating;	A 30% B 27%

: 75-21-8
oxirane

: 110-85-0
piperazine

A: 103-76-4
1-(2-hydroxyethyl)piperazine

B: 122-96-3
1,4-bis(2-hydroxyethyl)piperazine

Conditions

Conditions	Yield
With methanol
With methanol

...Expand

: Ethoxy-phenoxy-piperazin-1-yl-methanethiol

A: 103-76-4
1-(2-hydroxyethyl)piperazine

B: 116849-48-0
O-ethyl O'-phenyl thiocarbonate

Conditions

Conditions	Yield
With potassium chloride In water at 25℃; Rate constant;

N-<β-oxy-ethyl>-piperazine-N'-carboxylic acid ethyl ester: N-<β-oxy-ethyl>-piperazine-N'-carboxylic acid ethyl ester

: 103-76-4
1-(2-hydroxyethyl)piperazine

Conditions

Conditions	Yield
With hydrogenchloride

N,N'-bis-<2-hydroxy-ethyl>-ethylenediamine hydrochloride: N,N'-bis-<2-hydroxy-ethyl>-ethylenediamine hydrochloride

A: 110-85-0
piperazine

B: 103-76-4
1-(2-hydroxyethyl)piperazine

Conditions

Conditions	Yield
at 200℃;

: 89727-93-5
1-(2-bromo-ethyl)-piperazine; dihydrobromide

aqueous NaOH: aqueous NaOH

A: 103-76-4
1-(2-hydroxyethyl)piperazine

B isomeric compound to 2-piperazino-ethanol C6H14N2O: isomeric compound to 2-piperazino-ethanol C6H14N2O

Conditions

Conditions	Yield
at 50℃;

...Expand

: 56227-56-6
(4-(2-hydroxyethyl)piperazin-1-yl)(phenyl)methanone

: 103-76-4
1-(2-hydroxyethyl)piperazine

Conditions

Conditions	Yield
With hydrogenchloride Heating;

: 2-(3-trifluoromethyl-phenylamino)-nicotinic acid 2-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-2-oxo-ethyl ester

A: 103-76-4
1-(2-hydroxyethyl)piperazine

B: 2-(3-trifluoromethyl-phenylamino)nicotinic acid carboxymethyl ester

Conditions

Conditions	Yield
With phosphate buffer; potassium chloride In methanol at 37℃; for 8h; pH=7.4; Kinetics; Further Variations:; pH-values;

: 4-(2-Allyloxycarbonyloxy-ethyl)-piperazine-1-carboxylic acid 3-methyl-but-2-enyl ester

: 103-76-4
1-(2-hydroxyethyl)piperazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 100 percent / diethylamine / Pd(0) (in situ from Pd(OAc)2 and m.sulfonated triphenylphosphine) / H2O; various solvent(s) / 0.33 h / 5 molpercent catalyst 2: 100 percent / diethylamine / Pd(0) (in situ from Pd(OAc)2 and m.sulfonated triphenylphosphine) / H2O; acetonitrile / 0.25 h / 5 molpercent catalyst View Scheme

: 107-15-3
ethylenediamine

A: 110-85-0
piperazine

B: 103-76-4
1-(2-hydroxyethyl)piperazine

C: 140-31-8
aminoethylpiperazine

D: 111-41-1
2-(2-Aminoethylamino)ethanol

E: 111-40-0
1,5-diamino-3-azapentane

F: 112-24-3
triethylentetramine

Conditions

Conditions	Yield
With hydrogen at 150 - 160℃; under 22502.3 Torr;

...Expand

: 141-43-5
ethanolamine

A: 110-85-0
piperazine

B: 103-76-4
1-(2-hydroxyethyl)piperazine

C: 140-31-8
aminoethylpiperazine

D: 111-41-1
2-(2-Aminoethylamino)ethanol

E: 107-15-3
ethylenediamine

F: 111-40-0
1,5-diamino-3-azapentane

G: 112-24-3
triethylentetramine

Conditions

Conditions	Yield
With ammonia; hydrogen at 170℃; under 150015 Torr;

...Expand

: 110-85-0
piperazine

: 624-76-0
Iodoethanol

: 103-76-4
1-(2-hydroxyethyl)piperazine

Conditions

Conditions	Yield
With potassium carbonate; sodium iodide In ethanol for 12h; Reflux;

: 102-71-6
triethanolamine

A: 110-85-0
piperazine

B: 103-76-4
1-(2-hydroxyethyl)piperazine

C: 140-31-8
aminoethylpiperazine

Conditions

Conditions	Yield
With ammonia; hydrogen; Ni/Re (6.8wtpercent/1.8wtpercent) on silica/alumina (80/20) at 170℃; under 85781.4 - 99537.9 Torr; for 16h; Product distribution / selectivity; Autoclave;

...Expand

: 102-71-6
triethanolamine

A: 110-85-0
piperazine

B: 103-76-4
1-(2-hydroxyethyl)piperazine

C: 140-31-8
aminoethylpiperazine

D: 3197-06-6
N,N-bis(2-hydroxyethyl)ethylidenediamine

Conditions

Conditions	Yield
With ammonia; hydrogen; Ni/Re (6.8wtpercent/1.8wtpercent) on silica/alumina (80/20) at 170℃; under 85781.4 - 99537.9 Torr; for 10h; Product distribution / selectivity; Autoclave;

...Expand

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 24424-99-5
di-tert-butyl dicarbonate

: 77279-24-4
tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate

Conditions

Conditions	Yield
In tetrahydrofuran for 3h;	100%
With triethylamine In tetrahydrofuran	100%
In tetrahydrofuran for 2h;	100%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 845526-60-5
4-chlorobutyric acid 3-diethylaminopropyl ester

: 845526-69-4
4-[4-(2-hydroxyethyl)piperazin-1-yl]butyric acid 3-diethylaminopropyl ester

Conditions

Conditions	Yield
With potassium carbonate In toluene at 100℃; for 48h;	100%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 2923-96-8
4-fluoro-2-nitrobenzaldehyde

: 904896-09-9
4-[4-(2-hydroxyethyl)piperazin-1-yl]-2-nitrobenzaldehyde

Conditions

Conditions	Yield
In dimethyl sulfoxide at 100℃; for 1.5h;	100%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 501-53-1
benzyl chloroformate

: 14000-67-0
benzyl 4-(2-hydroxyethyl)-1-piperazinecarboxylate

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 20℃; for 3.5h;	100%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 24h;	91%
With sodium hydroxide In water; acetonitrile at 20℃; pH=9; Inert atmosphere;	90%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 1780-26-3
2,4-dichloro-2-methylpyrimidine

: 127116-19-2
2-(4-(6-chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 30℃;	100%
Stage #1: 1-(2-hydroxyethyl)piperazine; 2,4-dichloro-2-methylpyrimidine In dichloromethane at 30℃; for 2.5h; Stage #2: With triethylamine In dichloromethane	89.8%
Stage #1: 1-(2-hydroxyethyl)piperazine; 2,4-dichloro-2-methylpyrimidine In dichloromethane at 30℃; for 2.5h; Stage #2: With triethylamine In dichloromethane	89.8%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 1067884-35-8
(2′Z-3′E)-6-bromoindirubin-3′-[O-(2-bromoethyl)oxime]

: 1067884-47-2
(2'Z-3'E)-6-bromoindirubin-3'-(O-{2-[4-(2-hydroxyethyl)piperazin-1-yl]ethyl}oxime)

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 50℃;	100%
In N,N-dimethyl-formamide at 90℃; for 0.666667h; Inert atmosphere; Microwave irradiation;

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 105-34-0
methyl 2-cyanoacetate

: 15029-35-3
3-[4-(2-hydroxyethyl)piperazin-1-yl]-3-oxopropanenitrile

Conditions

Conditions	Yield
neat (no solvent);	100%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 1159982-72-5
5,7-dichloro-2-phenylpyrazolo[1,5-a]pyrimidine

: 1232224-20-2
5-Chloro-7-[1-(2-hydroxyethyl)-piperazin-4-yl]-2-phenyl-pyrazolo[1,5-a]-pyrimidine

Conditions

Conditions	Yield
In 1,4-dioxane at 1 - 30℃; for 1h;	100%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 95365-88-1
cis-10-(3-Dimethylamino-propyliden)-2-trifluormethyl-thiaxanthen

: 2709-56-0
2-{4-[3-(2-trifluoromethyl-thioxanthen-9-ylidene)-propyl]-piperazin-1-yl}-ethanol

Conditions

Conditions	Yield
at 140℃; for 36h; Temperature; Large scale;	100%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: N-[2,4-dibromo-6-methylpyridin-3-yl]-2-bromoacetamide

: N-[2,4-dibromo-6-methylpyridin-3-yl]-2-[4-(2-hydroxyethyl)piperazin-1-yl]acetamide

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 20℃; for 24h;	99%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 1254043-23-6
6-chloro-N-methyl-4-propylnicotinamide

: 1254043-24-7
6-[4-(2-hydroxyethyl)piperazin-1-yl]-N-methyl-4-propylnicotinamide

Conditions

Conditions	Yield
In tetrahydrofuran at 20 - 100℃; for 18h;	99%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 66074-00-8
3,4-bis(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide

: 1245575-37-4
3-(phenylsulfonyl)-4-(2-(piperazin-1-yl)ethoxy)-1,2,5-oxadiazole-2-oxide

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 0℃; for 4h;	99%
With sodium hydride In tetrahydrofuran at 0℃; for 4h;	99%
With sodium hydroxide In tetrahydrofuran; water at 0 - 20℃;	56%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 66298-49-5
4,6-diiodo-2-methylpyrimidine

: 2-(4-(6-iodo-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol

Conditions

Conditions	Yield
With triethylamine In isopropyl alcohol at 60℃; for 1h;	99%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 3,3'-bis(3-bromopropoxy)-2,2'-dimethyl-1,1'-biphenyl

: 76-05-1
trifluoroacetic acid

: 2,2'-((((2,2'-dimethyl-[1,1'-biphenyl]-3,3'-diyl)bis(oxy))bis(propane-3,1-diyl))bis(piperazine-4,1-diyl))bis(ethan-1-ol) trifluoroacetate

Conditions

Conditions	Yield
Stage #1: 1-(2-hydroxyethyl)piperazine; 3,3'-bis(3-bromopropoxy)-2,2'-dimethyl-1,1'-biphenyl With N-ethyl-N,N-diisopropylamine In methanol at 65℃; for 72h; Inert atmosphere; Stage #2: trifluoroacetic acid In water; acetonitrile	99%

...Expand

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 1'-(2-bromoacetyl)spiro[chromane-2,4'-piperidin]-4-one

: 1'-(2-(4-(2-hydroxyethyl)piperazin-1-yl)acetyl)spiro[chromane-2,4'-piperidin]-4-one

Conditions

Conditions	Yield
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 60℃; for 2h;	99%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 95893-90-6
2-(chloromethyl)-1-(ethoxyethyl)-1H-benzimidazole

: 95894-06-7
2-{4-[1-(2-Ethoxy-ethyl)-1H-benzoimidazol-2-ylmethyl]-piperazin-1-yl}-ethanol

Conditions

Conditions	Yield
In 1,4-dioxane at 50℃; for 2h;	98%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 4739-94-0
ethyl 2,3-dihydro-1,4-benzodioxin-2-carboxylate

: N-(2,3-dihydrobenzo<1,4>dioxin-2-carbonyl)-N'-(2-hydroxyethyl)piperazine

Conditions

Conditions	Yield
at 110℃; for 3h;	98%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 98596-13-5
methyl 6,11-dioxo-6,11- dihydrobenzo[f]pyrido [1,2-a]indole-12-carboxylate

: 12-[4-(2-hydroxy-ethyl)-piperazine-1-carbonyl]-benzo[f]pyrido[1,2-a]indole-6,11-dione

Conditions

Conditions	Yield
at 80℃; for 3h;	98%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 937394-83-7
methyl 7,10-dihydroxy-6,11-dioxo-6,11-dihydro-benzo[f]pyrido[1,2-a]indole-12-carboxylate

: 7,10-dihydroxy-12-[4-(2-hydroxy-ethyl)-piperazine-1-carbonyl]-benzo[f]pyrido[1,2-a]indole-6,11-dione

Conditions

Conditions	Yield
at 80℃; for 3h;	98%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: C16H20BrF3O4

: C22H33F3N2O5

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; for 5h;	98%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 459-57-4
4-fluorobenzaldehyde

: 4-benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In water at 100℃; for 12h;	98%
With potassium carbonate In water at 80℃; for 24h;	95%
With potassium carbonate In dimethyl sulfoxide at 100℃; for 12h;	70%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 1780-26-3
2,4-dichloro-2-methylpyrimidine

: 2-amino-7-hydroxy-4-(4-methoxyphenyl)-1,4-dihydroquinoline-3-carbonitrile

: 2-amino-7-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)oxy)-4-(4-methoxyphenyl)-1,4-dihydroquinoline-3-carbonitrile

Conditions

Conditions	Yield
Stage #1: 2-amino-7-hydroxy-4-(4-methoxyphenyl)-1,4-dihydroquinoline-3-carbonitrile With potassium carbonate In acetone at 20℃; for 0.25h; Stage #2: 2,4-dichloro-2-methylpyrimidine In acetone at 80℃; for 0.25h; Stage #3: 1-(2-hydroxyethyl)piperazine In acetone at 80℃; for 12h;	98%

...Expand

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 14625-39-9
2-(chloromethyl)-6-nitro-1H-benzo[d]imidazole

: 2-(4-((6-nitro-1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)ethan-1-ol

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 3h;	97.8%
With potassium carbonate In tetrahydrofuran at 20℃; for 1h;	87.6%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 5271-67-0
2-Thiophenecarbonyl chloride

: 80838-51-3
Thiophene-2-carboxylic acid 2-[4-(thiophene-2-carbonyl)-piperazin-1-yl]-ethyl ester

Conditions

Conditions	Yield
In benzene for 1h; Heating;	97%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 72966-79-1
2,6-bis(3-chloropropionamido)anthracene-9,10-dione

: 134888-47-4
2,6-bis<3-<4-(2-hydroxyethyl)piperazino>propionamido>anthracene-9,10-dione

Conditions

Conditions	Yield
In ethanol for 14h; Heating;	97%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 105189-21-7
2-chloro-4-(4-fluorophenyl)quinoline

: 105188-98-5
2-[4-(2-hydroxyethyl)-1-piperazinyl]-4-(4-fluorophenyl)quinoline dihydrochloride

Conditions

Conditions	Yield
at 130℃; for 2h;	97%
In water

: 185-78-4
1-thiaspiro<2.5>octane

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 2-[4-(1-mercapto-cyclohexylmethyl)-piperazin-1-yl]-ethanol

Conditions

Conditions	Yield
at 80℃; for 4h;	97%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 302964-08-5
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

: 302962-49-8
dasatanib

Conditions

Conditions	Yield
With tetrabutylammomium bromide In acetonitrile at 30 - 80℃;	97%
In propan-1-ol at 115 - 120℃; Temperature;	93%
With copper(l) chloride In N,N-dimethyl-formamide at 65℃; for 2h; Temperature; Reagent/catalyst;	91.6%

N-(2-Hydroxyethyl)piperazine Consensus Reports

Reported in EPA TSCA Inventory.

N-(2-Hydroxyethyl)piperazine Specification

The 1-(2-Hydroxyethyl)piperazine with CAS registry number of 103-76-4 is also known as (b-Hydroxyethyl)piperazine. The IUPAC name is 2-Piperazin-1-ylethanol. It belongs to product categories of Piperaizine. Its EINECS registry number is 203-142-3. In addition, the formula is C₆H₁₄N₂O and the molecular weight is 130.19. This chemical is a clear colorless to pale yellow oily liquid that miscible with water. It may cause inflammation to the skin or other mucous membranes and should be sealed in ventilated, cool, dry place away from fire, heat, oxidants. What's more, this chemical is used as for organic synthesis.

Physical properties about 1-(2-Hydroxyethyl)piperazine are: (1)ACD/LogP: -0.45; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.43; (4)ACD/LogD (pH 7.4): -2.15; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 15.71; (13)Index of Refraction: 1.475; (14)Molar Refractivity: 36.22 cm³; (15)Molar Volume: 128.6 cm³; (16)Polarizability: 14.35×10^-24 cm³; (17)Surface Tension: 34.7 dyne/cm; (18)Density: 1.012 g/cm³; (19)Flash Point: 101.9 °C; (20)Enthalpy of Vaporization: 56.01 kJ/mol; (21)Boiling Point: 245 °C at 760 mmHg; (22)Vapour Pressure: 0.00492 mmHg at 25°C; (23)Exact Mass: 130.110613; (24)MonoIsotopic Mass: 130.110613; (25)Topological Polar Surface Area: 35.5; (26)Heavy Atom Count: 9; (27)Complexity: 71.5; (28)Covalently-Bonded Unit Count: 1.

Preparation of 1-(2-Hydroxyethyl)piperazine: it is prepared by reaction of piperazine hexahydrate with ethylene oxide. Firstly, piperazine hexahydrate is dissolved in water, stirred and cooled to 15-20 °C. Then ethylene oxide is passed into solution and reaction occurs at the temperature of 30-35 °C for 2 hours under stirring. At last, product is obtained by cooling, filtration, vacuum distillation and collecting distillate at 145-155 °C (5.33kPa).

Use of 1-(2-Hydroxyethyl)piperazine: it is used to produce (2,3-dihydro-benzo[1,4]dioxin-2-yl)-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-methanone by reaction with 2,3-dihydro-benzo[1,4]dioxine-2-carboxylic acid ethyl ester. This reaction occurs at the temperature of 110 °C for 3 hours. The yield is about 98%.

1-(2-Hydroxyethyl)piperazine is used to produce (2,3-dihydro-benzo[1,4]dioxin-2-yl)-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-methanone by reaction with 2,3-dihydro-benzo[1,4]dioxine-2-carboxylic acid ethyl ester.

When you are using this chemical, please be cautious about it. As a chemical, it is irritating to eyes, respiratory system, skin and may have risk of serious damage to eyes. Therefore, you should wear suitable protective clothing, gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: C1CN(CCN1)CCO
2. InChI: InChI=1S/C6H14N2O/c9-6-5-8-3-1-7-2-4-8/h7,9H,1-6H2
3. InChIKey: WFCSWCVEJLETKA-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	oral	3720mg/kg (3720mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(5), Pg. 67, 1980.
mouse	LD50	intraperitoneal	100mg/kg (100mg/kg)		National Technical Information Service. Vol. AD277-689,
rabbit	LD50	oral	3350mg/kg (3350mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(5), Pg. 67, 1980.
rabbit	LD50	skin	> 5mL/kg (5mL/kg)		Union Carbide Data Sheet. Vol. 1/6/1970,
rat	LD50	oral	4920uL/kg (4.92mL/kg)		American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.

Product Name

N-(2-Hydroxyethyl)piperazine

Synthetic route

N-(2-Hydroxyethyl)piperazine Consensus Reports

N-(2-Hydroxyethyl)piperazine Specification

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