N-Methyl-DL-alanine supplier

Name
N-ME-DL-ALA-OH HCL
EINECS
CAS No. 600-21-5
Article Data23
CAS DataBase
Density 1.048 g/cm³
Solubility
Melting Point 317 °C
Formula C₄H₉NO₂
Boiling Point 190.1 °C at 760 mmHg
Molecular Weight 103.121
Flash Point 68.8 °C
Transport Information
Appearance white crystalline powder
Safety
Risk Codes
Molecular Structure
Hazard Symbols Xi
Synonyms Methylalanine, dl-;N-Methylalanine;
PSA 49.33000
LogP 0.87180

Synthetic route

: 598-72-1
2-Bromopropionic acid

: 74-89-5
methylamine

: 600-21-5
N-methylalanine

Conditions

Conditions	Yield
In ethanol at 0 - 20℃; for 48h;	90%
With water

: 101692-94-8
(rac)-N-benzyl-N-methylalanine

: 600-21-5
N-methylalanine

Conditions

Conditions	Yield
With 10% Pd/C; hydrogen In acetic acid	70%
With hydrogen; palladium on activated charcoal

: 7464-68-8
1,2-dimethyl-4-nitro-1H-imidazole

: 600-21-5
N-methylalanine

Conditions

Conditions	Yield
With hydrogenchloride; tin(ll) chloride

: 57658-79-4
1,4-dimethyl-5-nitro-1H-imidazole

A: 871885-96-0
1,5-dimethyl-1H-imidazol-4-ylamine

B: 600-21-5
N-methylalanine

Conditions

Conditions	Yield
With hydrogenchloride; tin(ll) chloride at 10℃;

: 16752-54-8
methylaminopropionitrile

: 600-21-5
N-methylalanine

Conditions

Conditions	Yield
With hydrogenchloride
With potassium hydroxide

: 74-89-5
methylamine

: 535-13-7
2-chloro-propanoic acid, ethyl ester

: 600-21-5
N-methylalanine

Conditions

Conditions	Yield
With water at 120 - 130℃; Destillieren des Produkts und Kochen den Rueckstand mit Baryt;

: 74-89-5
methylamine

: 535-11-5, 41978-69-2
Ethyl 2-bromopropionate

: 600-21-5
N-methylalanine

Conditions

Conditions	Yield
With water at 140℃; Kochen des das erhaltene Gemisch der α-Methyl-amino-propionsaeure und ihres Methylamids mit Barytwasser;

: 98026-07-4
2-(1-Methyl-hydrazino)-propionsaeure

: 600-21-5
N-methylalanine

Conditions

Conditions	Yield
With acetic acid; sodium nitrite

: 127-17-3
2-oxo-propionic acid

: 103-67-3
benzyl-methyl-amine

: 600-21-5
N-methylalanine

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In ethanol

: 74-89-5
methylamine

: 598-78-7
(R,S)-2-chloropropionic acid

: 600-21-5
N-methylalanine

Conditions

Conditions	Yield
In water

: 32012-16-1
α-N-methylaminopropionamide

: 600-21-5
N-methylalanine

Conditions

Conditions	Yield
With potassium hydroxide; ammonia pH: 13.6;

: 7647-01-0
hydrogenchloride

: 7464-68-8
1,2-dimethyl-4-nitro-1H-imidazole

tin (II)-chloride: tin (II)-chloride

A: 871885-96-0
1,5-dimethyl-1H-imidazol-4-ylamine

B: 600-21-5
N-methylalanine

...Expand

DL-2--propionic acid: DL-2--propionic acid

: 600-21-5
N-methylalanine

Conditions

Conditions	Yield
With sulfuric acid

: 74-89-5
methylamine

DL-2-chloro-propionic acid: DL-2-chloro-propionic acid

: 600-21-5
N-methylalanine

Conditions

Conditions	Yield
at 40℃;

sodium salt of methylene-dl-alanine: sodium salt of methylene-dl-alanine

: 600-21-5
N-methylalanine

Conditions

Conditions	Yield
With ethanol; sodium in der Siedehitze;

: 74-89-5
methylamine

C: C

A: 107-97-1
sarcosine

B: 600-21-5
N-methylalanine

C: 617-45-8
aspartic Acid

Conditions

Conditions	Yield
With ammonia Yield given. Further byproducts given. Yields of byproduct given;

...Expand

: 7664-93-9
sulfuric acid

: N-methyl-N-(phenylsulfonyl)alanine

: 600-21-5
N-methylalanine

: 64-17-5
ethanol

: N-methylen-alanine ; sodium salt

sodium: sodium

: 600-21-5
N-methylalanine

Conditions

Conditions	Yield
in der Siedehitze;

...Expand

: 600-21-5
N-methylalanine

: 40162-09-2
N-methyl-N-nitrosoalanine

Conditions

Conditions	Yield
With 3,3-dimethyl-2-nitroso-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide In 1,2-dichloro-ethane at 80℃; Sealed tube;	97%
With hydrogenchloride; sodium nitrite

: 57543-84-7
2-phenyl-3-nitro-2H-chromene

: 600-21-5
N-methylalanine

: 91-56-5
indole-2,3-dione

: (1S*,3S*,3aS*,4R*,9bR*)-2,3-dimethyl-3a-nitro-4-phenyl-2,3,3a,9b-tetrahydro-4H-spiro[chromeno[3,4-c]pyrrole-1,3’-indolin]-2’-one

Conditions

Conditions	Yield
In isopropyl alcohol at 55 - 60℃; for 5h;	95%

...Expand

: 600-21-5
N-methylalanine

: 3716-97-0
1,2-dicyanocyclobutene

: 77418-65-6
1,2,7-trimethylazepine-3,6-dicarbonitrile

Conditions

Conditions	Yield
With acetic anhydride at 95℃; for 6h;	93%

: 600-21-5
N-methylalanine

: 6-Chloro-3-nitro-2-(trifluoromethyl)-2H-chromene

: 91-56-5
indole-2,3-dione

: (1S*,3S*,3aS*,4S*,9bR*)-8-chloro-2,3-dimethyl-3a-nitro-4-(trifluoromethyl)-2,3,3a,9b-tetrahydro-4H-spiro[chromeno[3,4-c]pyrrole-1,3’-indolin]-2’-one

Conditions

Conditions	Yield
In isopropyl alcohol at 55 - 60℃; for 5h;	93%

...Expand

: 600-21-5
N-methylalanine

: 6,8-Dibromo-3-nitro-2-(trifluoromethyl)-2H-chromene

: 91-56-5
indole-2,3-dione

: (1S*,3S*,3aS*,4S*,9bR*)-6,8-dibromo-2,3-dimethyl-3a-nitro-4-(trifluoromethyl)-2,3,3a,9b-tetrahydro-4H-spiro[chromeno[3,4-c]pyrrole-1,3’-indolin]-2’-one

Conditions

Conditions	Yield
In isopropyl alcohol at 55 - 60℃; for 5h;	91%

...Expand

: 600-21-5
N-methylalanine

: 17356-08-0
thiourea

: 1,5-dimethyl-2-thioxoimidazolidin-4-one

Conditions

Conditions	Yield
at 180 - 195℃; for 1.25h;	90%

: 890095-37-1
3-nitro-2-(trifluoromethyl)-2H-chromene

: 600-21-5
N-methylalanine

: 91-56-5
indole-2,3-dione

: (1S*,3S*,3aS*,4S*,9bR*)-2,3-dimethyl-3a-nitro-4-(trifluoromethyl)-2,3,3a,9b-tetrahydro-4H-spiro[chromeno[3,4-c]pyrrole-1,3’-indolin]-2’-one

Conditions

Conditions	Yield
In isopropyl alcohol at 55 - 60℃; for 5h;	89%

...Expand

: 600-21-5
N-methylalanine

: 24424-99-5
di-tert-butyl dicarbonate

: 13734-31-1
(S)-N-tert-butoxycarbonyl-N-methyl-2-amino-propionic acid

Conditions

Conditions	Yield
Stage #1: N-methylalanine; di-tert-butyl dicarbonate In methanol; water at 20℃; for 23.0833h; Stage #2: With citric acid In methanol; water pH=3;	88%

: 1003573-84-9
6-methoxy-3-nitro-2-trifluoromethyl-2H-chromene

: 600-21-5
N-methylalanine

: 91-56-5
indole-2,3-dione

: (1S*,3S*,3aS*,4S*,9bR*)-8-methoxy-2,3-dimethyl-3a-nitro-4-(trifluoromethyl)-2,3,3a,9b-tetrahydro-4H-spiro[chromeno[3,4-c]pyrrole-1,3’-indolin]-2’-one

Conditions

Conditions	Yield
In isopropyl alcohol at 55 - 60℃; for 5h;	88%

...Expand

: 890095-37-1
3-nitro-2-(trifluoromethyl)-2H-chromene

: 2058-74-4
1-methyl-1H-indole-2,3-dione

: 600-21-5
N-methylalanine

: (1S*,3S*,3aS*,4R*,9bR*)-1’,2,3-trimethyl-3a-nitro-4-(trifluoromethyl)-2,3,3a,9b-tetrahydro-4H-spiro[chromeno[3,4-c]pyrrole-1,3’-indolin]-2’-one

Conditions

Conditions	Yield
In isopropyl alcohol at 55 - 60℃; for 5h;	87%

...Expand

: 600-21-5
N-methylalanine

: 3-nitro-2-(trifluoromethyl)-2-phenyl-2H-chromene

: 91-56-5
indole-2,3-dione

: (1S*,3S*,3aS*,4S*,9bR*)-2,3,8-trimethyl-3a-nitro-4-(trifluoromethyl)-2,3,3a,9b-tetrahydro-4H-spiro[chromeno[3,4-c]pyrrole-1,3’-indolin]-2’-one

Conditions

Conditions	Yield
In isopropyl alcohol at 55 - 60℃; for 5h;	85%

...Expand

: 600-21-5
N-methylalanine

: 2-(2-(5-amino-1,3,4-thiadiazol-2-yl)ethyl)-3-((5-amino-1,3,4-thiadiazol-2-yl)methyl)quinazolin-4(3H)-one

: 2-(methylamino)-N-(5-((2-(2-(5-(2-(methylamino)propanamido)-1,3,4-thiadiazol-2-yl)ethyl)-4-oxoquinazolin-3(4H)-yl)methyl)-1,3,4-thiadiazol-2-yl)propanamide

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In tetrahydrofuran for 24h;	85%

: 64-18-6
formic acid

: 600-21-5
N-methylalanine

: 108732-17-8
N-formyl-N-methyl-D,L-alanine

Conditions

Conditions	Yield
With acetic anhydride for 12h; Ambient temperature;	84%

: 600-21-5
N-methylalanine

: 1217-89-6
1-benzylisatin

: 21728-28-9
(2-oxo-1,2-dihydro-indol-3-ylidene)-acetic acid ethyl ester

: C30H29N3O4

Conditions

Conditions	Yield
In methanol at 30℃; for 28h; diastereoselective reaction;	84%

...Expand

: 600-21-5
N-methylalanine

: 383-63-1
ethyl trifluoroacetate,

: N-methyl-N-trifluoroacetylalanine

Conditions

Conditions	Yield
With N,N,N',N'-tetramethylguanidine In methanol at 20℃; for 14h;	80.4%

: 1631-26-1
1-benzyl-1H-pyrrole-2,5-dione

: 600-21-5
N-methylalanine

: 91-56-5
indole-2,3-dione

: 4-benzyl-1,6-dimethylpyrrolidino[3,4-c]pyrrole-2-spiro-3'-(2-oxindole)-3,5-dione

Conditions

Conditions	Yield
In methanol at 90℃; for 18h;	79%

...Expand

: 3,6-dinitro-2-trifluoromethyl-2H-chromene

: 600-21-5
N-methylalanine

: 91-56-5
indole-2,3-dione

: (1S*,3S*,3aS*,4S*,9bR*)-2,3-dimethyl-3a,8-dinitro-4-(trifluoromethyl)-2,3,3a,9b-tetrahydro-4H-spiro[chromeno[3,4-c]pyrrole-1,3’-indolin]-2’-one

Conditions

Conditions	Yield
In isopropyl alcohol at 55 - 60℃; for 5h;	79%

...Expand

: 600-21-5
N-methylalanine

: 79-04-9
chloroacetyl chloride

: 138062-74-5
N-Chloracetyl-N-methyl-DL-alanin

Conditions

Conditions	Yield
With hydroxide	73%
With sodium hydroxide

: 64-17-5
ethanol

: 600-21-5
N-methylalanine

: 814-68-6
acryloyl chloride

: N-acryloyl-N-methylalanine ethyl ester

Conditions

Conditions	Yield
Stage #1: ethanol; N-methylalanine With thionyl chloride Cooling with ice; Stage #2: With potassium carbonate In water at 20℃; for 1h; Stage #3: acryloyl chloride In water at 20℃; for 2h; Cooling with ice;	71%

...Expand

: 890095-37-1
3-nitro-2-(trifluoromethyl)-2H-chromene

: 608-05-9
5-methyl-indole-2,3-dione

: 600-21-5
N-methylalanine

: (1S*,3S*,3aS*,4R*,9bR*)-2,3,5’-trimethyl-3a-nitro-4-(trifluoromethyl)-2,3,3a,9b-tetrahydro-4Hspiro[chromeno[3,4-c]pyrrole-1,3’-indolin]-2’-one

Conditions

Conditions	Yield
In isopropyl alcohol at 55 - 60℃; for 5h;	70%

...Expand

: 600-21-5
N-methylalanine

: 108-24-7
acetic anhydride

: 70717-18-9
N-acetyl-N-methylalanine

Conditions

Conditions	Yield
With sodium hydroxide at 50℃; for 1.5h;	66%

: 600-21-5
N-methylalanine

: 19241-36-2
5-chloro-2-methylphenylisothiocyanate

: 3-(5-chloro-2-methyl-phenyl)-1,5-dimethyl-2-thioxo-imidazolidin-4-one

Conditions

Conditions	Yield
With triethylamine In chloroform for 18h; Heating;	64%

: 600-21-5
N-methylalanine

: 98-59-9
p-toluenesulfonyl chloride

: 374622-04-5
N-methyl-N-[(4-methylphenyl)sulfonyl]alanine

Conditions

Conditions	Yield
With sodium carbonate In water	63.6%

: 600-21-5
N-methylalanine

: 27646-78-2
2-(methylamino)propan-1-ol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 70℃; for 16h;	61%
With lithium aluminium tetrahydride; diethyl ether

: 292638-84-7
styrene

: 600-21-5
N-methylalanine

: 609-36-9
rac-Pro-OH

: 6,10-dimethyl-7-phenyl-6,7,8,9-tetrahydro-5H-6,9-epiminopy-rrolo[1,2-a]azepin-5-o ne

Conditions

Conditions	Yield
With acetic acid at 110℃; for 24h; Inert atmosphere; Sealed tube; Green chemistry;	60%

...Expand

: 600-21-5
N-methylalanine

: 65211-53-2
2-Prop-2-ynyloxybenzoic acid chloride

: 120801-39-0
N-methyl-N-<2-(prop-2-ynyloxy)benzoyl>alanine

Conditions

Conditions	Yield
With sodium hydroxide In benzene for 0.5h;	58%

: 600-21-5
N-methylalanine

: 100-51-6
benzyl alcohol

: N-methylalanine benzyl ester hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; thionyl chloride at 95 - 100℃; for 7h;	56%

: 600-21-5
N-methylalanine

: 98-09-9
benzenesulfonyl chloride

: N-methyl-N-(phenylsulfonyl)alanine

Conditions

Conditions	Yield
With sodium carbonate In water	51.7%

N-Methyl-DL-alanine Specification

The CAS registry number of N-Methyl-DL-alanine is 600-21-5. In addition, the molecular formula is C₄H₉NO₂ and the molecular weight is 103.12. The IUPAC name is 2-(methylamino)propanoic acid and it is also called N-Methyl-L-alanine, (2S)-2-(methylamino)propanoic acid, CHEMBL1234201, CHEBI:17519, 3913-67-5, N-Methyl alanine, Methylalanine. What's more, it should be stored in sealed container, and put in a cool and dry place.

Physical properties about N-Methyl-DL-alanine are: (1)ACD/LogP: -0.45; (2)ACD/LogD (pH 5.5): -2.94; (3)ACD/LogD (pH 7.4): -2.95; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 3; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 2; (11)Polar Surface Area: 29.54 Å²; (12)Index of Refraction: 1.435; (13)Molar Refractivity: 25.69 cm³; (14)Molar Volume: 98.3 cm³; (15)Polarizability: 10.18 ×10^-24cm³; (16)Surface Tension: 34.4 dyne/cm; (17)Density: 1.048 g/cm³; (18)Flash Point: 68.8 °C; (19)Enthalpy of Vaporization: 46.99 kJ/mol; (20)Boiling Point: 190.1 °C at 760 mmHg; (21)Vapour Pressure: 0.244 mmHg at 25°C.

Uses of N-Methyl-DL-alanine: it can react with 2-prop-2-ynyloxy-benzoyl chloride to get N-methyl-N-[2-(prop-2-ynyloxy)benzoyl]alanine. This reaction will need reagent aq. NaOH and solvent benzene. The reaction time is 0.5 hour. And the yield is about 80%.

DL-Alanine, N-methyl- can react with 2-prop-2-ynyloxy-benzoyl chloride to get N-methyl-N-[2-(prop-2-ynyloxy)benzoyl]alanine

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(O)C(NC)C
(2)Std.InChI: InChI=1S/C4H9NO2/c1-3(5-2)4(6)7/h3,5H,1-2H3,(H,6,7)
(3)Std.InChIKey: GDFAOVXKHJXLEI-UHFFFAOYSA-N

Product Name

N-ME-DL-ALA-OH HCL

Synthetic route

N-Methyl-DL-alanine Specification

Related Products

Hot Products