N-Methylcyclohexylamine supplier

Name
N-Methylcyclohexylamine
EINECS 202-869-3
CAS No. 100-60-7
Article Data99
CAS DataBase
Density 0.868 g/cm³
Solubility 5.4 g/100 mL (20 °C) in water
Melting Point -9--7 °C(lit.)
Formula C₇H₁₅N
Boiling Point 146.5 °C at 760 mmHg
Molecular Weight 113.203
Flash Point 29.4 °C
Transport Information UN 2734 8/PG 2
Appearance clear colourless to yellow liquid
Safety 16-26-36/37/39-45
Risk Codes 10-21/22-35-20/21/22
Molecular Structure
Hazard Symbols C
Synonyms Cyclohexylamine,N-methyl- (6CI,7CI,8CI);(Methylamino)cyclohexane;Cyclohexylmethylamine;Methylcyclohexylamine;N-Cyclohexyl-N-methylamine;N-Cyclohexylmethylamine;N-Methyl-N-cyclohexylamine;N-Methylcyclohexanamine;NSC 434;
PSA 12.03000
LogP 1.92940

Synthetic route

: 108-94-1
cyclohexanone

: 124-40-3
dimethyl amine

A: 100-60-7
N-methylcyclohexylamine

B: 98-94-2
N,N-dimethyl-cyclohexanamine

C: 108-93-0
cyclohexanol

Conditions

Conditions	Yield
With hydrogen at 160 - 220℃; under 67506.8 - 97509.8 Torr; for 100 - 1000h; Product distribution / selectivity;	A 0.1% B 96% C 0.5%
With hydrogen at 160 - 180℃; under 63756.4 - 97509.8 Torr; for 100 - 400h; Product distribution / selectivity;	A 0.1% B 94% C 2%

...Expand

: 109-73-9
N-butylamine

: 3-methyl-2-(N-methylcyclohexylamino)benzothiazolium iodide

A: 70038-63-0
butyl-(3-methyl-3H-benzothiazol-2-ylidene)-amine

B: 100-60-7
N-methylcyclohexylamine

Conditions

Conditions	Yield
at 25℃; for 3h;	A 95% B 83%
In dichloromethane at 25℃; for 3h;	A 95% B 83%

...Expand

: 931-53-3
Cyclohexyl isocyanide

: 100-60-7
N-methylcyclohexylamine

Conditions

Conditions	Yield
With Zr12(μ3-O)5[(μ3-O)CoCl]8[(μ2-O)2(μ3-O)CoCl]3Li3(triphenyldicarboxylate)9; hydrogen In toluene at 110℃; under 30003 Torr; for 42h; Catalytic behavior; Inert atmosphere; Schlenk technique;	92%
With dimethyl sulfoxide In water at 100℃; Green chemistry;	65%

: 100-61-8
N-methylaniline

: 100-60-7
N-methylcyclohexylamine

Conditions

Conditions	Yield
With hydrogen In neat (no solvent) at 80℃; under 7600.51 Torr; for 24h; Catalytic behavior; Autoclave;	91%
With dichloro(μ-chloro)(μ-hydrido)bis(η-p-cymene)diruthenium(II); hydrogen In neat (no solvent) at 75℃; under 37503.8 Torr; for 24h;	80%
With lithium; methylamine

: 593-51-1
methylamine hydrochloride

: 108-94-1
cyclohexanone

: 100-60-7
N-methylcyclohexylamine

Conditions

Conditions	Yield
With iridium bromide; zinc In 1,4-dioxane; water at 30℃; for 72h;	85%
With titanium(IV) isopropylate; sodium tetrahydroborate; triethylamine 1.) EtOH, 25 deg C, 10 h, 2.) EtOH, 25 deg C, 8 h; Yield given. Multistep reaction;

: 108-94-1
cyclohexanone

: 74-89-5
methylamine

: 100-60-7
N-methylcyclohexylamine

Conditions

Conditions	Yield
With hydrogenchloride; Zr(BH4)2Cl2(dabco)2 In methanol for 1h; Heating;	78%
With D-glucose; glucose dehydrogenase CDX-901; imine reductase 48 from Rhizobium sullae; nicotinamide adenine dinucleotide phosphate In aq. buffer at 25℃; for 24h; pH=9; Enzymatic reaction;	66%
With sodium tetrahydroborate; lithium chloride In tetrahydrofuran; methanol Flow reactor; chemoselective reaction;	37%

: 67-56-1
methanol

: 108-91-8
cyclohexylamine

: 100-60-7
N-methylcyclohexylamine

Conditions

Conditions	Yield
With rhodium(III) chloride hydrate; potassium tert-butylate at 130℃; for 48h; Sealed tube; High pressure;	75%
With thorium dioxide at 320℃;
rhodium hydrido (PEt3)3 complex for 10h;	99 % Chromat.
With platinum on carbon; hydrogen; sodium hydroxide at 130℃; under 30003 Torr; for 36h; Autoclave;	74 %Chromat.
With palladium 10% on activated carbon; potassium tert-butylate at 130℃; for 12h;

: 141339-38-0
N-(6-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-N-methyl-hydroxylamine

: 100-60-7
N-methylcyclohexylamine

Conditions

Conditions	Yield
With carbon disulfide In acetonitrile for 1.5h; Ambient temperature;	71%

: 15267-95-5
chloromethyltriethoxysilane

: 108-91-8
cyclohexylamine

: 100-60-7
N-methylcyclohexylamine

Conditions

Conditions	Yield
Stage #1: chloromethyltriethoxysilane; cyclohexylamine at 87℃; for 18h; Stage #2: With water In ethanol for 48h; Heating; Further stages.;	68%

: Cyclohexyl-phenylsulfanylmethyl-amine; hydrochloride

: 100-60-7
N-methylcyclohexylamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether -60 degC -> room temp.;	67%

: 138710-07-3
N-(benzenesulfenyl)-N-methylcyclohexylamine

: 100-60-7
N-methylcyclohexylamine

Conditions

Conditions	Yield
With tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) In cyclohexane Heating;	53%
With tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) In cyclohexane for 0.25h; Mechanism; Product distribution; Heating; other conditions: other solvent, no reagents and catalysts; other sulpenamides as starting material; Competitive reaction of C-SPh compound 11 with Bu3nH: comparison of the reactivities of N-SPh and C-SPh bonds;

: 108-94-1
cyclohexanone

: 74-89-5
methylamine

A: 100-60-7
N-methylcyclohexylamine

B: 108-93-0
cyclohexanol

Conditions

Conditions	Yield
With hydrogenchloride; sodium tetrahydroborate In isopropyl alcohol at 20 - 30℃;	A 45% B 40%
With potassium hydroxide; potassium phosphate In water at 18 - 20℃; pH 12, electrochemical reaction;

...Expand

: 108-91-8
cyclohexylamine

: 616-38-6
carbonic acid dimethyl ester

A: 100-60-7
N-methylcyclohexylamine

B: 98-94-2
N,N-dimethyl-cyclohexanamine

Conditions

Conditions	Yield
With binder-free NaY zeolite Heating;	A 5% B n/a

...Expand

: 186581-53-3, 908094-01-9
diazomethane

: 108-91-8
cyclohexylamine

A: 100-60-7
N-methylcyclohexylamine

B: 98-94-2
N,N-dimethyl-cyclohexanamine

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate

...Expand

: 98-94-2
N,N-dimethyl-cyclohexanamine

: 100-60-7
N-methylcyclohexylamine

Conditions

Conditions	Yield
With sodium hydroxide; potassium hexacyanoferrate(III)
With diethyl ether; bromocyane und Erhitzen des hierbei erhaltenen Reaktionsprodukts mit wss. H2SO4;
With naphthalene-1,4-dicarbonitrile In methanol; acetonitrile for 0.166667h; UV-irradiation;	11 % Chromat.

: 766-93-8
N-cyclohexylformamide

: 100-60-7
N-methylcyclohexylamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; diethyl ether

: 1074-58-4
N-(cyanomethyl)cyclohexylamine

A: 100-60-7
N-methylcyclohexylamine

B: 5700-53-8
N-cyclohexylethylenediamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; diethyl ether

: 2739-12-0
N-methylaniline hydrochloride

A: 100-60-7
N-methylcyclohexylamine

B: 7560-83-0
N-Methyldicyclohexylamine

Conditions

Conditions	Yield
With ethanol; platinum at 70℃; under 1520 - 2280 Torr; Hydrogenation;

: 22906-85-0
4-methylamino-phenol; hydrochloride

A: 100-60-7
N-methylcyclohexylamine

B: 2987-05-5
4-(methylamino)cyclohexanol

Conditions

Conditions	Yield
With water; platinum under 2280 Torr; Hydrogenation.entsteht ein Gemisch von cis- und trans-Form;

: 123-39-7
N-Methylformamide

: 108-94-1
cyclohexanone

A: 100-60-7
N-methylcyclohexylamine

B: 7560-83-0
N-Methyldicyclohexylamine

Conditions

Conditions	Yield
With formic acid

...Expand

: 60-29-7
diethyl ether

: 108-91-8
cyclohexylamine

: 77-78-1
dimethyl sulfate

A: 100-60-7
N-methylcyclohexylamine

B: 98-94-2
N,N-dimethyl-cyclohexanamine

...Expand

: 108-91-8
cyclohexylamine

: 77-78-1
dimethyl sulfate

: 100-60-7
N-methylcyclohexylamine

Conditions

Conditions	Yield
With diethyl ether

: 16770-34-6
N-(α-phenylbenzylidene)cyclohexylamine

: 74-88-4
methyl iodide

A: 119-61-9
benzophenone

B: 100-60-7
N-methylcyclohexylamine

Conditions

Conditions	Yield
anschliessend beim Kochen mit 90prozentigem Alkohol;

...Expand

: 6154-14-9
N-chloromethylamine

: 127146-33-2
cyclohexyl-dimethylborane

: 100-60-7
N-methylcyclohexylamine

Conditions

Conditions	Yield
a) 0 deg C, 5-10 min, b) RT, 60 min; Yield given;

: 101-81-5
Diphenylmethane

: 84602-11-9
lithium cyclohexyl(methyl)amide

A: 100-60-7
N-methylcyclohexylamine

B: 881-42-5
diphenylmethyllithium

Conditions

Conditions	Yield
In tetrahydrofuran at 30℃; Equilibrium constant;

...Expand

: 519-73-3
triphenylmethane

: 84602-11-9
lithium cyclohexyl(methyl)amide

A: 100-60-7
N-methylcyclohexylamine

B: 733-90-4
trityllithium

Conditions

Conditions	Yield
In tetrahydrofuran at 30℃; Equilibrium constant;

...Expand

: 6281-14-7
1,3,5-tricyclohexyl-[1,3,5]triazinane

: 100-60-7
N-methylcyclohexylamine

Conditions

Conditions	Yield
With hydrogenchloride; zinc

: 67-56-1
methanol

: 108-91-8
cyclohexylamine

A: 100-60-7
N-methylcyclohexylamine

B: 98-94-2
N,N-dimethyl-cyclohexanamine

Conditions

Conditions	Yield
ruthenium trichloride; tri-n-butyl phosphite In 1,4-dioxane at 180℃; for 15h;	A 3 % Chromat. B 14 % Chromat.
With carbonylhydrido(tetrahydroborato)[bis(2-diphenylphosphinoethyl)amino]ruthenium(II); hydrogen at 120℃; under 30003 Torr; for 24h; Glovebox;	A n/a B 31 %Spectr.
With C19H37IrN4(2+)2Cl(1-)2H2O; potassium carbonate at 50℃; for 17h; Reagent/catalyst; Inert atmosphere; Schlenk technique; Sealed tube;	A 14 %Chromat. B 61 %Chromat.
With hydrogen at 55℃; under 750.075 Torr; for 24h; Irradiation; Green chemistry;

...Expand

: 15294-11-8
Methyltrimethoxyphosphonium tetrafluoroborate

: 108-91-8
cyclohexylamine

A: 100-60-7
N-methylcyclohexylamine

B: 98-94-2
N,N-dimethyl-cyclohexanamine

Conditions

Conditions	Yield
for 12h; Ambient temperature; Yield given. Yields of byproduct given;

...Expand

: 100-60-7
N-methylcyclohexylamine

: 59565-09-2
2-(vinyloxy)ethyl isothiocyanate

: 121612-59-7
1-Cyclohexyl-1-methyl-3-(2-vinyloxy-ethyl)-thiourea

Conditions

Conditions	Yield
	100%

: 100-60-7
N-methylcyclohexylamine

: 65439-58-9
2-phenyl-1-(2-thioxothiazolidin-3-yl)ethan-1-one

: 74472-25-6
N-cyclohexyl-N-methyl-2-phenylacetamide

Conditions

Conditions	Yield
	100%
In dichloromethane for 0.0333333h; Ambient temperature;	100%

: 100-60-7
N-methylcyclohexylamine

: 931-59-9
benzenesulfenyl chloride

: 138710-07-3
N-(benzenesulfenyl)-N-methylcyclohexylamine

Conditions

Conditions	Yield
With triethylamine In diethyl ether for 0.166667h;	100%

: 100-60-7
N-methylcyclohexylamine

: 32315-10-9
bis(trichloromethyl) carbonate

: 35028-38-7
N-methyl-N-cyclohexylaminocarbonyl chloride

Conditions

Conditions	Yield
With pyridine In toluene	100%
With pyridine In toluene
With pyridine In dichloromethane at 20℃; for 2h;

: 67-56-1
methanol

: 100-60-7
N-methylcyclohexylamine

: 98-94-2
N,N-dimethyl-cyclohexanamine

Conditions

Conditions	Yield
chloro(cyclopentadienyl)bis(triphenylphosphine)ruthenium (II) at 100℃;	100%
With rhodium(III) chloride hydrate; potassium tert-butylate at 130℃; for 48h; Sealed tube; High pressure;	45%
With Ru(OAc)2(1,1′-bis(diisopropylphosphino)ferrocene)(CO); trifluoroacetic acid at 100℃; for 24h; Temperature; Inert atmosphere; Schlenk technique;
With palladium 10% on activated carbon; potassium tert-butylate at 130℃; for 14h;

: 100-60-7
N-methylcyclohexylamine

: 5432-28-0
N-nitroso-N-methylcyclohexylamine

Conditions

Conditions	Yield
With trichloroisocyanuric acid; silica gel; sodium nitrite In dichloromethane at 20℃; for 0.25h;	99%
With sulfuric acid; silica gel; sodium nitrite In dichloromethane at 20℃; for 0.166667h;	98%
With N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide; water; silica gel; sodium nitrite In dichloromethane at 20℃; for 0.0666667h; Reagent/catalyst;	98%

: 100-60-7
N-methylcyclohexylamine

: 74058-64-3
1-(2-Thioxo-thiazolidin-3-yl)-hexadecan-1-one

: 74058-73-4
N-cyclohexyl-N-methylhexadecanamide

Conditions

Conditions	Yield
In dichloromethane for 0.166667h; Ambient temperature;	99%

: 100-60-7
N-methylcyclohexylamine

: 7154-66-7
2-bromobenzoic acid chloride

: 349395-89-7
2-bromo-N-cyclohexyl-N-methylbenzamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 2h; Ambient temperature;	99%
With N-ethyl-N,N-diisopropylamine In diethyl ether at 0 - 20℃; Inert atmosphere;	4.5 g

: 100-60-7
N-methylcyclohexylamine

: 3680-69-1
4-chloro-1H-pyrrolo[2,3-d]pyrimidine

: 252722-30-8
N-cyclohexyl-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Conditions

Conditions	Yield
In 1,4-dioxane at 110℃; for 9h; Microwave irradiation; Sealed tube;	99%
Stage #1: N-methylcyclohexylamine; 4-chloro-1H-pyrrolo[2,3-d]pyrimidine In tert-butyl alcohol at 100℃; for 24h; Stage #2: With hydrogenchloride In water; tert-butyl alcohol pH=1; Stage #3: With sodium hydroxide In water; tert-butyl alcohol pH=14;	88%
In tert-butyl alcohol at 85℃;

: 108-75-8
2,4,6-trimethyl-pyridine

: 100-60-7
N-methylcyclohexylamine

: 7664-93-9
sulfuric acid

: 1643-19-2
tetrabutylammomium bromide

: N-Isobutenyloxycarbonyl-N-methylcyclohexylamine

Conditions

Conditions	Yield
In 1,1,2,2-tetrachloroethylene	99%

...Expand

: 100-60-7
N-methylcyclohexylamine

: 3433-80-5
1-Bromo-2-bromomethyl-benzene

: 92299-13-3
N-(2-bromobenzyl)-N-methylcyclohexylamine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide Inert atmosphere;	99%

: 3034-52-4
2-chlorothiazole

: 100-60-7
N-methylcyclohexylamine

: N-cyclohexyl-N-methylthiazol-2-amine

Conditions

Conditions	Yield
With C50H61Cl2N3Pd; potassium tert-butylate In 1,4-dioxane at 100℃; for 2h;	99%

: 615-18-9
2-chloro-1,3-benzoxazole

: 100-60-7
N-methylcyclohexylamine

: 34173-49-4
N-cyclohexyl-N-methylbenzo[d]oxazol-2-amine

Conditions

Conditions	Yield
With C50H61Cl2N3Pd; potassium tert-butylate In 1,4-dioxane at 100℃; for 2h;	99%

: 100-60-7
N-methylcyclohexylamine

: 10026-11-6
zirconium(IV) chloride

: 610786-42-0
tetrakis(cyclohexylmethylamide)zirconium

Conditions

Conditions	Yield
With Li-n-Bu In hexane; toluene in oxygen and moisture free atmosphere; soln. of ligand in toluene addeddropwise to soln. of Li-n-Bu in hexane; stirred at room temp. for 2.5 h ; ZrCl4 added gradually for 30 min; stirred for 18 h; filtered; filtrate reduced to oil under reduced pressure; elem. anal.;	98.7%

: 120-72-9
indole

: 100-60-7
N-methylcyclohexylamine

: 75-09-2
dichloromethane

: Cyclohexyl-(1H-indol-3-ylmethyl)-methyl-amine

Conditions

Conditions	Yield
In methanol at 50℃; under 6000480 Torr; for 96h;	98%

...Expand

: 100-60-7
N-methylcyclohexylamine

: 16024-82-1
methyl 2-isothiocyanatobenzoate

: 905486-98-8
methyl 2-(3-cyclohexyl-3-methylthioureido)benzoate

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 3h;	98%
In dichloromethane at 20℃;

: 10531-78-9
5-methyl-1,3-benzoxazole

: 100-60-7
N-methylcyclohexylamine

: 1323158-79-7
N-cyclohexyl-N'-(2-hydroxy-5-methylphenyl)-N-methylmethanimidamide

Conditions

Conditions	Yield
at 80℃; for 12h;	98%
In acetonitrile at 80℃; for 10h;

: 100-60-7
N-methylcyclohexylamine

: 609-67-6
2-Iodobenzoyl chloride

: 1083239-65-9
N-cyclohexyl-2-iodo-N-methylbenzamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 5h;	98%

: 100-60-7
N-methylcyclohexylamine

: 1038502-72-5
1-tosyl-4-vinyl-1,4-dihydro-2H-benzo[d] [1,3]oxazin-2-one

: (S)-N-(2-(1-(cyclohexyl(methyl)amino)allyl)phenyl)-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
Stage #1: N-methylcyclohexylamine With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 1-((11bS)-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl)-1,2,3,4-tetrahydroquinoline In tetrahydrofuran at -10 - 20℃; for 0.166667h; Schlenk technique; Inert atmosphere; Stage #2: 1-tosyl-4-vinyl-1,4-dihydro-2H-benzo[d] [1,3]oxazin-2-one In tetrahydrofuran at -10℃; for 5h; Schlenk technique; Inert atmosphere; enantioselective reaction;	98%

Yield

Stage #1: N-methylcyclohexylamine With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 1-((11bS)-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl)-1,2,3,4-tetrahydroquinoline In tetrahydrofuran at -10 - 20℃; for 0.166667h; Schlenk technique; Inert atmosphere;
Stage #2: 1-tosyl-4-vinyl-1,4-dihydro-2H-benzo[d] [1,3]oxazin-2-one In tetrahydrofuran at -10℃; for 5h; Schlenk technique; Inert atmosphere; enantioselective reaction;

98%

: 100-60-7
N-methylcyclohexylamine

: 227617-16-5
ethyl 4-chloro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

: ethyl 4-(cyclohexyl(methyl)amino)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

Conditions

Conditions	Yield
In ethanol at 80℃; for 2h; Inert atmosphere;	98%

: 100-60-7
N-methylcyclohexylamine

: 24424-99-5
di-tert-butyl dicarbonate

: tert-butyl cyclohexyl(methyl)carbamate

Conditions

Conditions	Yield
With saccharin sulfonic acid In hexane at 20℃; for 1h;	97%
With piperazine functionalized zirconium-Fe3O4-MCM-41 magnetic nanoparticles In neat (no solvent) at 20℃; for 0.166667h; Time;	91%
With 1,3-disulfonic acid imidazolium hydrogen sulfate In neat (no solvent) at 20℃; for 0.166667h; Green chemistry; chemoselective reaction;	90%

: 100-60-7
N-methylcyclohexylamine

: 471-25-0
Propiolic acid

: 1309932-49-7
N-cyclohexyl-N-methylpropiolamide

Conditions

Conditions	Yield
Stage #1: Propiolic acid With pivaloyl chloride; potassium carbonate In tetrahydrofuran for 1h; Inert atmosphere; Cooling; Stage #2: N-methylcyclohexylamine In tetrahydrofuran for 1h; Inert atmosphere;	97%

: 590-28-3
potassium cyanate

: 100-60-7
N-methylcyclohexylamine

: 586-78-7
para-nitrophenyl bromide

: 1442042-63-8
1-cyclohexyl-3-(4-nitrophenyl)-1-methyl-urea

Conditions

Conditions	Yield
With copper(I) oxide; 2-(2,6-dimethylphenyl-amino)-2-oxoacetic acid potassium salt In acetonitrile at 110℃; Schlenk technique; Inert atmosphere;	97%

...Expand

: 591-50-4
iodobenzene

: 100-60-7
N-methylcyclohexylamine

: 18707-43-2
N-cyclohexyl-N-methylaniline

Conditions

Conditions	Yield
With [Pd{C6H4(CH2N(CH2Ph)2)}(μ-Br)]2; potassium hydroxide In dimethyl sulfoxide at 120℃; for 0.5h;	97%
With sodium t-butanolate In dimethyl sulfoxide at 110℃; for 12h; Buchwald-Hartwig Coupling; Green chemistry;	95%
With sodium t-butanolate In dimethyl sulfoxide at 110℃; for 12h; Buchwald-Hartwig Coupling;	87%
With potassium hydroxide In dimethyl sulfoxide at 120℃; for 0.666667h;	75%
With copper(l) iodide; cesium fluoride In dimethyl sulfoxide at 130℃; for 24h; Ullmann Condensation; Inert atmosphere; Glovebox;

: 50-00-0
formaldehyd

: 100-60-7
N-methylcyclohexylamine

: 135-19-3
β-naphthol

: N-[methyl(2-naphthyl)]-N-methyl-N-cyclohexylamine

Conditions

Conditions	Yield
In methanol; water for 0.25h; Inert atmosphere;	97%

...Expand

: 100-60-7
N-methylcyclohexylamine

: 85716-87-6
ethyl 2-isothiocyanato-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

: 207743-82-6
2-(3-Cyclohexyl-3-methyl-thioureido)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester

Conditions

Conditions	Yield
In dichloromethane for 5h; Ambient temperature;	96%
In dichloromethane at 20℃; for 3h;

: 100-60-7
N-methylcyclohexylamine

: 108-94-1
cyclohexanone

: 62372-47-8
N-cyclohexyl-N-methylcyclohex-1-enamine

Conditions

Conditions	Yield
With titanium tetrachloride In cyclohexane at 0 - 20℃; Inert atmosphere;	96%

: 100-60-7
N-methylcyclohexylamine

: 2905-25-1
o-bromobenzenesulfonyl chloride

: 1022649-92-8
2-bromo-N-cyclohexyl-N-methylbenzenesulfonamide

Conditions

Conditions	Yield
With dmap; triethylamine In tetrahydrofuran at 20℃; for 16h; Inert atmosphere;	96%

: 100-60-7
N-methylcyclohexylamine

: 154318-75-9
4-tert-butylphenyl triflate

: C17H27N*ClH

Conditions

Conditions	Yield
Stage #1: N-methylcyclohexylamine; 4-tert-butylphenyl triflate With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); XPhos In tetrahydrofuran at 80℃; for 16h; Buchwald-Hartwig Coupling; Inert atmosphere; Sealed tube; Stage #2: With hydrogenchloride In diethyl ether Inert atmosphere;	96%

N-Methylcyclohexylamine Chemical Properties

MF: C₇H₁₅N
MW: 113.2
EINECS: 202-869-3
mp -9 ~ -7 °C(lit.)
bp 149 °C(lit.)
density 0.868 g/mL at 25 °C(lit.)
vapor density 4 (vs air)
vapor pressure 11 mm Hg ( 40 °C)
refractive index n20/D 1.456(lit.)
Fp 85 °F
storage temp. Flammables area
Water Solubility 5.4 g/100 mL (20 ^oC)
Sensitive Air Sensitive

N-Methylcyclohexylamine Toxicity Data With Reference

RTECS GX1529000

N-Methylcyclohexylamine Safety Profile

Hazard Codes C
Risk Statements 10-21/22-35-20/21/22
Safety Statements 16-26-36/37/39-45
RIDADR UN 2734 8/PG 2
WGK Germany 1
Hazard Note Corrosive
HazardClass 8

Product Name

N-Methylcyclohexylamine

Synthetic route

N-Methylcyclohexylamine Chemical Properties

N-Methylcyclohexylamine Toxicity Data With Reference

N-Methylcyclohexylamine Safety Profile

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