Naphthalene-1,8-diol supplier

Name
1,8-DIHYDROXYNAPHTHALENE
EINECS 209-316-5
CAS No. 569-42-6
Article Data42
CAS DataBase
Density 1.33g/cm³
Solubility
Melting Point 142-143℃
Formula C₁₀H₈O₂
Boiling Point 375.4 °C at 760 mmHg
Molecular Weight 160.172
Flash Point 193.5 °C
Transport Information
Appearance
Safety 26-39
Risk Codes 41
Molecular Structure
Hazard Symbols Xi
Synonyms 1,8-Dihydroxynaphthalene;Naphthalene-1,8-diol;
PSA 40.46000
LogP 2.25100

Synthetic route

: 83-31-8
1,8-naphthosultone

: 569-42-6
1,8-dihydroxynaphthalene

Conditions

Conditions	Yield
With potassium hydroxide at 300℃; for 0.5h;	86%
With potassium hydroxide; water at 225℃; for 0.5h;	83%
With potassium hydroxide at 300℃; for 0.5h;	80%

: 1,1-dimethyl-1H,3H-naphtho[1,8-cd][1,2,6]oxasilaborinin-3-ol

: 569-42-6
1,8-dihydroxynaphthalene

Conditions

Conditions	Yield
With dihydrogen peroxide In tetrahydrofuran; methanol; dodecane at 20℃;	67%

: 1,8-naphthalenesultone

: 569-42-6
1,8-dihydroxynaphthalene

Conditions

Conditions	Yield
With potassium hydroxide for 0.25h; Inert atmosphere;	60%

: 1,8-naphthosultone

: 569-42-6
1,8-dihydroxynaphthalene

Conditions

Conditions	Yield
Stage #1: 1,8-naphthosultone With potassium hydroxide; sodium hydroxide at 210℃; for 0.75h; Inert atmosphere; Stage #2: With sulfuric acid; water at 0℃;	53%

: 117-22-6
8-hydroxy-naphthalene-1-sulfonic acid

: 569-42-6
1,8-dihydroxynaphthalene

Conditions

Conditions	Yield
at 230℃; in der Kalischmelze;

: 83-65-8
4,5-dihydroxy-1-naphthalene-sulfonic acid

: 569-42-6
1,8-dihydroxynaphthalene

Conditions

Conditions	Yield
With sulfuric acid at 150℃;

: 603-72-5
1,8-naphthosultam

: 569-42-6
1,8-dihydroxynaphthalene

Conditions

Conditions	Yield
bei der Kalischmelze;

: furan-2,3,5(4H)-trione pyridine (1:1)

: 82-75-7
8-anilino-1-naphthalenesulfonate

A: 569-42-6
1,8-dihydroxynaphthalene

B: 2834-91-5
8-amino-1-naphthol

C: 117-22-6
8-hydroxy-naphthalene-1-sulfonic acid

D: 134-32-7
1-amino-naphthalene

Conditions

Conditions	Yield
at 220 - 300℃; im Autoklaven;

...Expand

: 82-75-7
8-anilino-1-naphthalenesulfonate

: 569-42-6
1,8-dihydroxynaphthalene

Conditions

Conditions	Yield
With sodium hydroxide at 220 - 230℃; unter Druck;
Multi-step reaction with 2 steps 1: 92 percent / NaNO2, aq. HCl / H2O / 1 h / Heating 2: KOH / neat (no solvent) / 1.75 h / 250 - 255 °C View Scheme

: 3588-75-8
8-methoxy-naphthalen-1-ol

A: 569-42-6
1,8-dihydroxynaphthalene

B: 930-73-4
1-methyl pyridinium iodide

Conditions

Conditions	Yield
With pyridine; pyridine hydroiodide at 115℃; Rate constant; LiI, KI, var. temp.;

: 81418-05-5
2,2-Di-tert-butyl-1,3-dioxa-2-sila-phenalene

: 569-42-6
1,8-dihydroxynaphthalene

Conditions

Conditions	Yield
With pyridine hydrogenfluoride In tetrahydrofuran at 25℃;

: 104422-22-2
8-Ethoxy-naphthalen-1-ol

A: 569-42-6
1,8-dihydroxynaphthalene

B: 872-90-2
N-ethylpyridinium iodide

Conditions

Conditions	Yield
With pyridine; lithium iodide at 115℃; Rate constant;

: 122127-76-8
1-methoxymethoxy-8-hydroxynaphthalene

: 569-42-6
1,8-dihydroxynaphthalene

Conditions

Conditions	Yield
With hydrogenchloride at 65℃; Rate constant;
With hydrogenchloride; ethylenediaminetetraacetic acid; buffer solution; sodium perchlorate; sodium iodide at 65℃; Rate constant; pH=3.5-9.7;

: 91-20-3
naphthalene

A: 132-86-5
1,3-dihydroxynaphthalene

B: 569-42-6
1,8-dihydroxynaphthalene

Conditions

Conditions	Yield
With water; oxygen; titanium(IV) oxide In acetonitrile Oxidation; Irradiation;

: 91-20-3
naphthalene

A: 571-60-8
1,4-Dihydroxynaphthalene

B: 90-15-3
α-naphthol

C: 582-17-2
2,7-Dihydroxynaphthalene

D: 569-42-6
1,8-dihydroxynaphthalene

E: 83-56-7
1,5-dihydroxynaphthalene

F: 135-19-3
β-naphthol

G all disubstituted naphthalenes; trisubstituted naphthalenes: all disubstituted naphthalenes; trisubstituted naphthalenes

Conditions

Conditions	Yield
With n-butyllithium; potassium tert-butylate Product distribution; multistep reaction; isomer distribution as a function of the solvent and conditions (THF only monosubstitution), also after reaction with Me2SO4;

...Expand

1.8-dioxy-naphthalene-disulfonic acid-(2.4): 1.8-dioxy-naphthalene-disulfonic acid-(2.4)

: 569-42-6
1,8-dihydroxynaphthalene

Conditions

Conditions	Yield
With sulfuric acid at 160℃;

naphthalene-sultone-(1.8): naphthalene-sultone-(1.8)

: 569-42-6
1,8-dihydroxynaphthalene

Conditions

Conditions	Yield
With potassium hydroxide; water

sultam of/the/ 1-oxy-naphthalene-sulfonic acid-(8): sultam of/the/ 1-oxy-naphthalene-sulfonic acid-(8)

: 569-42-6
1,8-dihydroxynaphthalene

Conditions

Conditions	Yield
durch Kalischmelze;

sultone of/the/ 1-oxy-naphthalene-sulfonic acid-(8): sultone of/the/ 1-oxy-naphthalene-sulfonic acid-(8)

: 569-42-6
1,8-dihydroxynaphthalene

Conditions

Conditions	Yield
With potassium hydroxide
With potassium hydroxide; water at 200 - 230℃;

: 7664-93-9
sulfuric acid

: 23894-05-5
4,5-dihydroxy-naphthalene-1,3-disulfonic acid

: 569-42-6
1,8-dihydroxynaphthalene

Conditions

Conditions	Yield
at 160℃;

: 7664-93-9
sulfuric acid

: 83-65-8
4,5-dihydroxy-1-naphthalene-sulfonic acid

: 569-42-6
1,8-dihydroxynaphthalene

Conditions

Conditions	Yield
at 150℃;

: 91-20-3
naphthalene

A: 571-60-8
1,4-Dihydroxynaphthalene

B: 132-86-5
1,3-dihydroxynaphthalene

C: 569-42-6
1,8-dihydroxynaphthalene

Conditions

Conditions	Yield
With dihydrogen peroxide; titanium(IV) oxide In water; acetonitrile for 1h; Product distribution; Quantum yield; Further Variations:; catalyst kind, reagent concentration; dihydroxylation; Irradiation;

...Expand

: dimethyl-(8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-1-yl)silane

: 569-42-6
1,8-dihydroxynaphthalene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: [Ru(p-cypene)Cl2]2 / acetonitrile / 20 °C 2: dihydrogen peroxide / tetrahydrofuran; methanol; dodecane / 20 °C View Scheme
With dihydrogen peroxide; sodium hydroxide In tetrahydrofuran; water at 0 - 20℃; for 0.25h; Inert atmosphere;	16.1 %Spectr.
Multi-step reaction with 2 steps 1: [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 / neat (no solvent) / 1 h / 20 °C / Inert atmosphere 2: dihydrogen peroxide; potassium hydrogencarbonate; tetrabutyl ammonium fluoride / tetrahydrofuran; water; methanol / 14 h / 0 - 40 °C / Inert atmosphere View Scheme

: 38274-80-5
dimethyl(naphthalen-1-yl)silane

: 569-42-6
1,8-dihydroxynaphthalene

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: 3,4,7,8-Tetramethyl-o-phenanthrolin; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere; Glovebox 1.2: 80 °C / Inert atmosphere; Sealed tube 2.1: [Ru(p-cypene)Cl2]2 / acetonitrile / 20 °C 3.1: dihydrogen peroxide / tetrahydrofuran; methanol; dodecane / 20 °C View Scheme
Multi-step reaction with 2 steps 1: bis(1,5-cyclooctadiene)diiridium(I) dichloride; 3,4,7,8-Tetramethyl-o-phenanthrolin / tetrahydrofuran / 3 h / 80 °C / Inert atmosphere 2: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; water / 0.25 h / 0 - 20 °C / Inert atmosphere View Scheme
Multi-step reaction with 2 steps 1: bis(1,5-cyclooctadiene)diiridium(I) dichloride; 3,4,7,8-Tetramethyl-o-phenanthrolin / tetrahydrofuran / 4 h / 80 °C / Inert atmosphere 2: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; water / 0.25 h / 0 - 20 °C / Inert atmosphere View Scheme
Multi-step reaction with 3 steps 1: bis(1,5-cyclooctadiene)diiridium(I) dichloride; 3,4,7,8-Tetramethyl-o-phenanthrolin / tetrahydrofuran / 3 h / 80 °C / Inert atmosphere 2: [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 / neat (no solvent) / 1 h / 20 °C / Inert atmosphere 3: dihydrogen peroxide; potassium hydrogencarbonate; tetrabutyl ammonium fluoride / tetrahydrofuran; water; methanol / 14 h / 0 - 40 °C / Inert atmosphere View Scheme
Multi-step reaction with 3 steps 1: bis(1,5-cyclooctadiene)diiridium(I) dichloride; 3,4,7,8-Tetramethyl-o-phenanthrolin / tetrahydrofuran / 4 h / 80 °C / Inert atmosphere 2: [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 / neat (no solvent) / 1 h / 20 °C / Inert atmosphere 3: dihydrogen peroxide; potassium hydrogencarbonate; tetrabutyl ammonium fluoride / tetrahydrofuran; water; methanol / 14 h / 0 - 40 °C / Inert atmosphere View Scheme

: 90-11-9
1-Bromonaphthalene

: 569-42-6
1,8-dihydroxynaphthalene

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: n-butyllithium / hexane; tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere 1.2: 0.5 h / -78 - 20 °C / Inert atmosphere 2.1: 3,4,7,8-Tetramethyl-o-phenanthrolin; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere; Glovebox 2.2: 80 °C / Inert atmosphere; Sealed tube 3.1: [Ru(p-cypene)Cl2]2 / acetonitrile / 20 °C 4.1: dihydrogen peroxide / tetrahydrofuran; methanol; dodecane / 20 °C View Scheme
Multi-step reaction with 3 steps 1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 20 °C / Inert atmosphere 2: bis(1,5-cyclooctadiene)diiridium(I) dichloride; 3,4,7,8-Tetramethyl-o-phenanthrolin / tetrahydrofuran / 3 h / 80 °C / Inert atmosphere 3: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; water / 0.25 h / 0 - 20 °C / Inert atmosphere View Scheme
Multi-step reaction with 3 steps 1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 20 °C / Inert atmosphere 2: bis(1,5-cyclooctadiene)diiridium(I) dichloride; 3,4,7,8-Tetramethyl-o-phenanthrolin / tetrahydrofuran / 4 h / 80 °C / Inert atmosphere 3: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; water / 0.25 h / 0 - 20 °C / Inert atmosphere View Scheme
Multi-step reaction with 4 steps 1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 20 °C / Inert atmosphere 2: bis(1,5-cyclooctadiene)diiridium(I) dichloride; 3,4,7,8-Tetramethyl-o-phenanthrolin / tetrahydrofuran / 3 h / 80 °C / Inert atmosphere 3: [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 / neat (no solvent) / 1 h / 20 °C / Inert atmosphere 4: dihydrogen peroxide; potassium hydrogencarbonate; tetrabutyl ammonium fluoride / tetrahydrofuran; water; methanol / 14 h / 0 - 40 °C / Inert atmosphere View Scheme
Multi-step reaction with 4 steps 1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 20 °C / Inert atmosphere 2: bis(1,5-cyclooctadiene)diiridium(I) dichloride; 3,4,7,8-Tetramethyl-o-phenanthrolin / tetrahydrofuran / 4 h / 80 °C / Inert atmosphere 3: [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 / neat (no solvent) / 1 h / 20 °C / Inert atmosphere 4: dihydrogen peroxide; potassium hydrogencarbonate; tetrabutyl ammonium fluoride / tetrahydrofuran; water; methanol / 14 h / 0 - 40 °C / Inert atmosphere View Scheme

: methoxydimethyl(8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-1-yl)silane

: 569-42-6
1,8-dihydroxynaphthalene

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride; dihydrogen peroxide; potassium hydrogencarbonate In tetrahydrofuran; methanol; water at 0 - 40℃; for 14h; Inert atmosphere;	19.2 mg

: 117-56-6
1-naphthol-4,8-disulfonic acid

: 569-42-6
1,8-dihydroxynaphthalene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: beim Verschmelzen 2: sulfuric acid / 150 °C View Scheme

: 60548-84-7
1,8-naphthylene phenylboronate

: 7732-18-5
water

A: 569-42-6
1,8-dihydroxynaphthalene

B: 98-80-6
phenylboronic acid

Conditions

Conditions	Yield
In dimethylsulfoxide-d6 at 20℃;

...Expand

: 569-42-6
1,8-dihydroxynaphthalene

: 74-88-4
methyl iodide

: 10075-66-8
1,8-dimethoxy-naphthalene

Conditions

Conditions	Yield
With potassium carbonate In acetone for 24h; Inert atmosphere; Reflux;	100%
With Aliquat (at)366; sodium hydroxide at 60 - 70℃; for 2h;	70%
With sodium hydroxide; tetrabutylammomium bromide In dichloromethane at 40℃; for 45h;	67%

: 569-42-6
1,8-dihydroxynaphthalene

: 105-36-2
ethyl bromoacetate

: diethyl 2,2'-(naphthalene-1,8-diylbis(oxy))diacetate

Conditions

Conditions	Yield
With potassium carbonate In acetone for 21h; Reflux;	100%

: 569-42-6
1,8-dihydroxynaphthalene

: 77-78-1
dimethyl sulfate

: 3588-75-8
8-methoxy-naphthalen-1-ol

Conditions

Conditions	Yield
Stage #1: 1,8-dihydroxynaphthalene With sodium hydride In tetrahydrofuran; mineral oil at 0℃; Inert atmosphere; Stage #2: dimethyl sulfate In tetrahydrofuran; mineral oil at 0 - 25℃; Inert atmosphere;	99%
Stage #1: 1,8-dihydroxynaphthalene With sodium hydride In tetrahydrofuran; mineral oil at 0℃; Inert atmosphere; Stage #2: dimethyl sulfate In tetrahydrofuran; mineral oil at 0 - 25℃; for 14h;	99%
With sodium hydroxide
With sodium hydroxide In diethyl ether

: 121-43-7
Trimethyl borate

: 569-42-6
1,8-dihydroxynaphthalene

: C11H9BO3

Conditions

Conditions	Yield
In dichloromethane at 20℃;	98%

: 569-42-6
1,8-dihydroxynaphthalene

: 2-(4-amino-2-hydroxybenzoyl)benzoic acid

: C24H15NO4

Conditions

Conditions	Yield
With methanesulfonic acid; trifluoroacetic acid at 80℃; for 24h;	97%

: 3876-61-7
1-benzoyl-2-bromoacetylene

: 569-42-6
1,8-dihydroxynaphthalene

: 2-(naphtho[1,8-de][1,3]dioxin-2-ylidene)-1-phenylethan-1-one

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere;	97%

: 569-42-6
1,8-dihydroxynaphthalene

: 74-88-4
methyl iodide

: 3588-75-8
8-methoxy-naphthalen-1-ol

Conditions

Conditions	Yield
With potassium carbonate In acetone at 23℃; for 24h;	96%
Stage #1: 1,8-dihydroxynaphthalene; methyl iodide With potassium carbonate In acetone at 18℃; for 10h; Stage #2: With hydrogenchloride In water; acetone	95%
With caesium carbonate In acetone for 4h; Inert atmosphere; Reflux;	84.4%

: 4375-83-1
tris(dimethylamino)borane

: 569-42-6
1,8-dihydroxynaphthalene

: C20H12BO4(1-)*H(1+)*C2H7N

Conditions

Conditions	Yield
In tetrahydrofuran for 1h;	96%

: 569-42-6
1,8-dihydroxynaphthalene

: 7695-47-8
8-hydroxy-1,2,3,4-tetrahydro-1-naphthalenone

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In ethanol at 60℃; under 3040.2 Torr; for 48h; Autoclave;	95%
With palladium on activated charcoal; hydrogen In ethanol at 60℃; for 24h;	74%
With aluminum (III) chloride In cyclohexane at 110℃; for 2h; Sealed tube;	70%
With aluminum (III) chloride In cyclohexane at 110℃; for 2h; Sealed tube;	30%
With ethanol; nickel Hydrogenation;

: 569-42-6
1,8-dihydroxynaphthalene

: 4923-58-4
3,5-dihydroxy-2,3-dihydro-1,4-naphthoquinone

Conditions

Conditions	Yield
With KO2 In tetrahydrofuran; toluene at -10℃; for 6h;	95%

: 569-42-6
1,8-dihydroxynaphthalene

: 10294-34-5
boron trichloride

: C10H6BClO2

Conditions

Conditions	Yield
In hexane; dichloromethane at -78 - 20℃;	95%

: 569-42-6
1,8-dihydroxynaphthalene

: 143418-49-9
3,4,5-trifluorophenylboronic acid

: C16H8BF3O2

Conditions

Conditions	Yield
In acetonitrile Heating;	95%

: 569-42-6
1,8-dihydroxynaphthalene

: 71-43-2
benzene

: 8-hydroxy-4-phenyl-1-tetralone

Conditions

Conditions	Yield
With aluminum (III) chloride at 20℃; for 48h; Reagent/catalyst;	93%

: 107070-67-7
2-(8-hydroxy-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline-9-carbonyl)benzoic acid

: 569-42-6
1,8-dihydroxynaphthalene

: C30H23NO4

Conditions

Conditions	Yield
With methanesulfonic acid; trifluoroacetic acid at 80℃; for 24h;	93%

: 4426-47-5
butylboronic acid

: 569-42-6
1,8-dihydroxynaphthalene

: C14H15BO2

Conditions

Conditions	Yield
In acetonitrile at 80℃;	93%

: 569-42-6
1,8-dihydroxynaphthalene

: 11113-50-1
boric acid

: C10H7BO3

Conditions

Conditions	Yield
In acetonitrile at 80℃; for 1h;	93%

: 569-42-6
1,8-dihydroxynaphthalene

: 481-39-0
5-hydroxynaphtho-1,4-quinone

Conditions

Conditions	Yield
With K10 montmorillonite; iodic acid for 0.366667h; Heating;	92%
With 1,1,1,3',3',3'-hexafluoro-propanol; urea hydrogen peroxide adduct at 45℃; Sealed tube; Green chemistry;	83%
With potassium nitrososulfonate; acetone

: 569-42-6
1,8-dihydroxynaphthalene

: 77-78-1
dimethyl sulfate

: 10075-66-8
1,8-dimethoxy-naphthalene

Conditions

Conditions	Yield
With potassium carbonate In acetone at 70℃; for 24h;	92%
With potassium hydroxide
In potassium hydroxide for 3h; Ambient temperature; Yield given;

: 75-30-9
2-iodo-propane

: 569-42-6
1,8-dihydroxynaphthalene

: 1257243-81-4
8-isopropoxynaphthalen-1-ol

Conditions

Conditions	Yield
With potassium carbonate In acetone at 20 - 56℃; for 20h;	92%

: 569-42-6
1,8-dihydroxynaphthalene

: 1-bromo-4,4-dimethyl-1-pentyn-3-one

: 3,3-dimethyl-1-(naphtho[1,8-de][1,3]dioxin-2-ylidene)butan-2-one

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere;	92%

: 569-42-6
1,8-dihydroxynaphthalene

: 182482-25-3
2,4,6-trifluorophenylboronic acid

: C16H8BF3O2

Conditions

Conditions	Yield
In acetonitrile Heating;	92%

: 463-71-8
thiophosgene

: 569-42-6
1,8-dihydroxynaphthalene

: 524047-44-7
naphtho[1,8-de][1,3]dioxine-2-thione

Conditions

Conditions	Yield
With pyridine; dmap In dichloromethane at -50℃;	91%

: 569-42-6
1,8-dihydroxynaphthalene

: 4-nitro-1,8-naphthalene diol

Conditions

Conditions	Yield
With copper nitrate hemi(pentahydrate); acetic anhydride; acetic acid at 25℃; for 5h;	91%
With aluminum(III) nitrate nonahydrate; acetic anhydride; acetic acid at 20℃; for 6h;	90%

: 569-42-6
1,8-dihydroxynaphthalene

: 107-30-2
chloromethyl methyl ether

: 172915-62-7
1,8-bis(methoxymethoxy)naphthalene

Conditions

Conditions	Yield
Stage #1: 1,8-dihydroxynaphthalene With sodium hydride In N,N-dimethyl-formamide at 0℃; Stage #2: chloromethyl methyl ether In diethyl ether; N,N-dimethyl-formamide for 6h;	90%
With sodium hydride In diethyl ether; N,N-dimethyl-formamide at 25℃;	88%
With sodium hydride In N,N-dimethyl-formamide at 0℃; for 1h;	85%

: 569-42-6
1,8-dihydroxynaphthalene

: 87293-26-3
4-bromo-3-butyn-2-one

: 1-(naphtho[1,8-de][1,3]dioxin-2-ylidene)propan-2-one

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere;	89%

: 569-42-6
1,8-dihydroxynaphthalene

: 2524-64-3
chlorophosphoric acid diphenyl ester

: 2-Phenoxy-1,3-dioxa-2-phospha-phenalene 2-oxide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 16h; Inert atmosphere; Sealed tube;	89%

: 569-42-6
1,8-dihydroxynaphthalene

: 141-97-9
ethyl acetoacetate

: 33396-80-4
10‐hydroxy‐4‐methyl‐2H‐benzo[h]chromen‐2‐one

Conditions

Conditions	Yield
With MnSb2O6-chitosan nanocomposite In neat (no solvent) at 80℃; for 0.583333h; Pechmann Condensation;	88%
With sulfuric acid
With hydrogenchloride; ethanol

: 569-42-6
1,8-dihydroxynaphthalene

: 75-03-6
ethyl iodide

: 104422-22-2
8-Ethoxy-naphthalen-1-ol

Conditions

Conditions	Yield
With sodium hydroxide; tetrabutylammomium bromide In dichloromethane at 40℃; for 24h;	88%

: 569-42-6
1,8-dihydroxynaphthalene

: 33892-75-0
5-Methoxy-1-tetralone

: 207504-79-8
5-Methoxy-1,2,3,4-tetrahydrospiro<1,3>dioxine>

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 48h; Heating;	86%
With sulfuric acid In toluene for 72h; Heating;	69%
With toluene-4-sulfonic acid In toluene for 72h; Reflux;	57%
With 4 A molecular sieve; p-toluenesulfonic acid monohydrate In toluene for 72h; Heating;	53%

Naphthalene-1,8-diol Chemical Properties

Molecular Structure of 1,8-Naphthalenediol (CAS NO.569-42-6):

IUPAC Name: naphthalene-1,8-diol
Empirical Formula: C₁₀H₈O₂
Molecular Weight: 160.1693
H bond acceptors: 2
H bond donors: 2
Freely Rotating Bonds: 2
Polar Surface Area: 18.46 Å²
Index of Refraction: 1.725
Molar Refractivity: 47.85 cm3
Molar Volume: 120.4 cm³
Surface Tension: 64.4 dyne/cm
Density: 1.33 g/cm³
Flash Point: 193.5 °C
Enthalpy of Vaporization: 64.73 kJ/mol
Boiling Point: 375.4 °C at 760 mmHg
Vapour Pressure: 3.62E-06 mmHg at 25°C
EINECS: 209-316-5
InChI
InChI=1/C10H8O2/c11-8-5-1-3-7-4-2-6-9(12)10(7)8/h1-6,11-12H
Smiles
c12c(O)cccc2cccc1O

Naphthalene-1,8-diol Specification

1,8-Naphthalenediol , with CAS number of 569-42-6, can be called 1,8-Dihydroxynaphthalene ; Naphthalene-1,8-diol .

Product Name

1,8-DIHYDROXYNAPHTHALENE

Synthetic route

Naphthalene-1,8-diol Chemical Properties

Naphthalene-1,8-diol Specification

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