Nitroguanidine supplier | CasNO.556-88-7

Name
Nitroguanidine
EINECS 209-143-5
CAS No. 556-88-7
Article Data34
CAS DataBase
Density 2.009 g/cm³
Solubility 3 g/L (20 ºC)
Melting Point 239 °C (dec.)(lit.)
Formula CH₄N₄O₂
Boiling Point 219.348 °C at 760 mmHg
Molecular Weight 104.068
Flash Point 86.459 °C
Transport Information UN 1336 4.1/PG 1
Appearance white needle crystal
Safety 16-26-33-36/37/39-47-37/39
Risk Codes 11-36/37/38-5
Molecular Structure
Hazard Symbols F,Xi
Synonyms Guanidine,nitro- (8CI,9CI);2-Nitroguanidine;N1-Nitroguanidine;NQ;NSC 41036;Nitroguanidine;N''-Nitroguanidine;Picrite;Picrite (propellant);a-Nitroguanidine;b-Nitroguanidine;
PSA 107.72000
LogP 0.37530

Synthetic route

: 506-93-4
guanidine nitrate

: 556-88-7
nitroguanidine

Conditions

Conditions	Yield
With sulfuric acid at 20℃;	100%
With 15-crown-5; nitric acid at 5 - 32℃; for 0.666667h; Reagent/catalyst; Temperature;	99.4%
With sulfuric acid

: 62154-79-4
nitro-azidocarboxamidine

: 556-88-7
nitroguanidine

Conditions

Conditions	Yield
With sodium dithionite

: 674-81-7
nitrosoguanidine

: 556-88-7
nitroguanidine

Conditions

Conditions	Yield
With potassium permanganate; nitric acid

: 593-84-0
guanidinium thiocyanate

: 556-88-7
nitroguanidine

Conditions

Conditions	Yield
With sulfuric acid; nitric acid
With sulfuric acid; nitric acid

: 594-14-9
guanidinium sulfate

: 556-88-7
nitroguanidine

Conditions

Conditions	Yield
With sulfuric acid; nitric acid at 20℃;
With sulfuric acid; nitric acid β-Form; nachfolgenden Erwaermen auf dem Wasserbad und Eingiessen in Eiswasser;
With nitric acid

: 7697-37-2
nitric acid

: 113-00-8
guanidine nitrate

: 556-88-7
nitroguanidine

Conditions

Conditions	Yield
reagiert das Guanidinsalz;

: 18264-75-0
3-amino-1-nitroguanidine

aqueous (NH4)2CO3: aqueous (NH4)2CO3

A: 556-88-7
nitroguanidine

B: 79-17-4
aminoguanidine

C: 302-01-2
hydrazine

D diaminoguanidine: diaminoguanidine

Conditions

Conditions	Yield
Produkt 5: Guanidin;

...Expand

α-form of nitroguanidine: α-form of nitroguanidine

: 556-88-7
nitroguanidine

Conditions

Conditions	Yield
β-Form; neben anderen Produkten;

β-nitroguanidine: β-nitroguanidine

: 556-88-7
nitroguanidine

Conditions

Conditions	Yield
With sulfuric acid; water α-Form;

benzenesulfonate guanylurea: benzenesulfonate guanylurea

: 556-88-7
nitroguanidine

Conditions

Conditions	Yield
With nitric acid

: 674-81-7
nitrosoguanidine

KMnO4: KMnO4

: 556-88-7
nitroguanidine

Conditions

Conditions	Yield
in schwach saurer Loesung;

: 674-81-7
nitrosoguanidine

: 7697-37-2
nitric acid

potassium permanganate: potassium permanganate

: 556-88-7
nitroguanidine

...Expand

: 86119-84-8, 7664-38-2
phosphoric acid

: 506-93-4
guanidine nitrate

P2O5: P2O5

: 556-88-7
nitroguanidine

...Expand

: guanidinium nitrate

: 556-88-7
nitroguanidine

Conditions

Conditions	Yield
With phosphoric acid; phosphorus pentoxide In not given addn. of guanidinium nitrate to a mixture consisting of 85% soln. of H3PO4 and P2O5; ambient temp.;
With sulfuric acid In not given addn. of guanidinium nitrate to 96 %-soln. of H2SO4; ambient temp.;
With H2SO4 In not given addn. of guanidinium nitrate to 96 %-soln. of H2SO4; ambient temp.;
With H3PO4; P2O5 In not given addn. of guanidinium nitrate to a mixture consisting of 85% soln. of H3PO4 and P2O5; ambient temp.;

: 556-88-7
nitroguanidine

: 5000-40-8, 33689-83-7, 60361-87-7, 74356-25-5
methylamine sulfate

: methyl nitroguanidine

Conditions

Conditions	Yield
With sodium hydroxide In water	95%

: 70258-18-3
2-chloro-5-(chloromethyl)pyridine

: 556-88-7
nitroguanidine

: 107-15-3
ethylenediamine

: 105827-78-9
1-(6-chloronicotinyl)-2-nitroiminoimidazoline

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water at 50℃; for 3h; pH=4 - 5; Reagent/catalyst; Temperature; pH-value; Ionic liquid;	93%

...Expand

: 556-88-7
nitroguanidine

: DNPM

: 201938-91-2
C10H7N5O4

Conditions

Conditions	Yield
With sodium methylate In methanol for 2.5h; Heating;	92%

: 556-88-7
nitroguanidine

: 104-87-0
4-methyl-benzaldehyde

: 109-77-3
malononitrile

: 1374981-19-7
4-amino-2-(nitroamino)-6-p-tolylpyrimidine-5-carbonitrile

Conditions

Conditions	Yield
With sodium hydroxide In ethanol for 1h; Reflux;	92%

...Expand

: 120-57-0
piperonal

: 556-88-7
nitroguanidine

: 109-77-3
malononitrile

: 1374981-26-6
4-amino-6-(benzo[d][1,3]dioxol-5-yl)-2-nitroaminopyrimidine-5-carbonitrile

Conditions

Conditions	Yield
With sodium hydroxide In ethanol for 0.5h; Reflux;	92%

...Expand

: 556-88-7
nitroguanidine

: 459-57-4
4-fluorobenzaldehyde

: 109-77-3
malononitrile

: 1374981-14-2
4-amino-6-(4-fluorophenyl)-2-nitroaminopyrimidine-5-carbonitrile

Conditions

Conditions	Yield
With sodium hydroxide In ethanol for 1h; Reagent/catalyst; Reflux;	91%

...Expand

: 556-88-7
nitroguanidine

: 1122-91-4
4-bromo-benzaldehyde

: 109-77-3
malononitrile

: 1374981-18-6
4-amino-6-(4-bromophenyl)-2-(nitroamino)pyrimidine-5-carbonitrile

Conditions

Conditions	Yield
With sodium hydroxide In ethanol for 1h; Reflux;	91%

...Expand

: 556-88-7
nitroguanidine

: 123-11-5
4-methoxy-benzaldehyde

: 109-77-3
malononitrile

: 1374981-22-2
4-amino-6-(4-methoxyphenyl)-2-nitroaminopyrimidine-5-carbonitrile

Conditions

Conditions	Yield
With sodium hydroxide In ethanol for 0.5h; Reflux;	91%

...Expand

: 556-88-7
nitroguanidine

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 109-77-3
malononitrile

: 1374981-24-4
4-amino-6-(3,4-dimethoxyphenyl)-2-nitroaminopyrimidine-5-carbonitrile

Conditions

Conditions	Yield
With sodium hydroxide In ethanol for 0.5h; Reflux;	91%

...Expand

: 556-88-7
nitroguanidine

: 7440-66-6
zinc

A: 7664-41-7
ammonia

B: 302-01-2
hydrazine

Conditions

Conditions	Yield
With sodium hydroxide In acetic acid redn. with Zn dust, than heating with NaOH under reflux, 8-10 h;	A n/a B 90%
With sodium hydroxide In acetic acid redn. with Zn dust, than heating with NaOH under reflux, 8-10 h;	A n/a B 90%

...Expand

: 556-88-7
nitroguanidine

A: 7664-41-7
ammonia

B: 10034-93-2
hydrazinium sulfate

Conditions

Conditions	Yield
With sodium hydroxide In acetic acid byproducts: Na2CO3; redn. in presence of Zn dust than reflux with NaOH for 8-10 h; cooling; react. with H2SO4;	A n/a B 90%
With sodium hydroxide In acetic acid byproducts: Na2CO3; redn. in presence of Zn dust than reflux with NaOH for 8-10 h; cooling; react. with H2SO4;	A n/a B 90%

: 556-88-7
nitroguanidine

: 104-88-1
4-chlorobenzaldehyde

: 109-77-3
malononitrile

: 1374981-15-3
4-amino-6-(4-chlorophenyl)-2-nitroaminopyrimidine-5-carbonitrile

Conditions

Conditions	Yield
With sodium hydroxide In ethanol for 1h; Reflux;	90%

...Expand

: 556-88-7
nitroguanidine

: 6287-38-3
3,4-dichlorobenzaldehyde

: 109-77-3
malononitrile

: 1374981-17-5
4-amino-6-(3,4-dichlorophenyl)-2-nitroaminopyrimidine-5-carbonitrile

Conditions

Conditions	Yield
With sodium hydroxide In ethanol for 0.5h; Reflux;	90%

...Expand

: 556-88-7
nitroguanidine

: 874-42-0
2,4-dichlorobenzaldeyhde

: 109-77-3
malononitrile

: 1374981-16-4
4-amino-6-(2,4-dichlorophenyl)-2-nitroaminopyrimidine-5-carbonitrile

Conditions

Conditions	Yield
With sodium hydroxide In ethanol for 0.5h; Reflux;	89%

...Expand

: 556-88-7
nitroguanidine

: 135-02-4
ortho-anisaldehyde

: 109-77-3
malononitrile

: 1374981-21-1
4-amino-6-(2-methoxyphenyl)-2-nitroaminopyrimidine-5-carbonitrile

Conditions

Conditions	Yield
With sodium hydroxide In ethanol for 0.5h; Reflux;	89%

...Expand

: 556-88-7
nitroguanidine

: 4460-86-0
asaraldehyde

: 109-77-3
malononitrile

: 4-amino-2-nitroamino-6-(3,4,5-trimethoxyphenyl)pyrimidine-5-carbonitrile

Conditions

Conditions	Yield
With sodium hydroxide In ethanol for 1h; Reflux;	89%

...Expand

: 556-88-7
nitroguanidine

: 221121-48-8
ethyl 4-(2,6-difluorophenyl)-2-methyl-3-oxobutanoate

: C12H10F2N4O3

Conditions

Conditions	Yield
With sodium ethanolate In ethanol for 5h; Heating;	88%

: 556-88-7
nitroguanidine

: 100-52-7
benzaldehyde

: 109-77-3
malononitrile

: 1374981-13-1
4-amino-2-nitroamino-6-phenylpyrimidine-5-carbonitrile

Conditions

Conditions	Yield
With sodium hydroxide In ethanol for 1h; Reflux;	88%

...Expand

: 556-88-7
nitroguanidine

: 93-02-7
2,5-dimethoxybenzaldehyde

: 109-77-3
malononitrile

: 1374981-23-3
4-amino-6-(2,5-dimethoxyphenyl)-2-nitroaminopyrimidine-5-carbonitrile

Conditions

Conditions	Yield
With sodium hydroxide In ethanol for 1h; Reflux;	87%

...Expand

: 5973-71-7
3,4-dimethylbenzaldehyde

: 556-88-7
nitroguanidine

: 109-77-3
malononitrile

: 1374981-20-0
4-amino-6-(3,4-dimethylphenyl)-2-nitroaminopyrimidine-5-carbonitrile

Conditions

Conditions	Yield
With sodium hydroxide In ethanol for 1h; Reflux;	86%

...Expand

: 556-88-7
nitroguanidine

: 221121-46-6
ethyl 4-(2,6-difluorophenyl)-3-oxobutanoate

: C11H8F2N4O3

Conditions

Conditions	Yield
With sodium ethanolate In ethanol for 5h; Heating;	85%

: 556-88-7
nitroguanidine

: 66-77-3
1-naphthaldehyde

: 109-77-3
malononitrile

: 1374981-27-7
4-amino-6-(naphthalene-1-yl)-2-nitroaminopyrimidine-5-carbonitrile

Conditions

Conditions	Yield
With sodium hydroxide In ethanol for 1h; Reflux;	85%

...Expand

: 556-88-7
nitroguanidine

: 1655-07-8
ethyl 2-oxocyclohexane carboxylate

: 54069-45-3
2-nitroamino-5,6,7,8-tetrahydro-4(3H)-quinazolinone

Conditions

Conditions	Yield
With sodium methylate at 20℃; for 0.75h; Heating / reflux;	84%

: 556-88-7
nitroguanidine

: 622-59-3
1-isothiocyanato-4-methylbenzene

: 90559-99-2
1-(4-methylphenyl)-3-(N-nitroamidino)thiourea

Conditions

Conditions	Yield
With potassium hydroxide In N,N-dimethyl-formamide 1.) r.t., 10 min, 2.) r.t., 30 min;	84%
With potassium hydroxide In N,N-dimethyl-formamide
With sodium hydroxide In dimethyl sulfoxide for 1h;
With potassium hydroxide In N,N-dimethyl-formamide at 20℃; for 1.5h;

: 556-88-7
nitroguanidine

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 1-(4-chlorophenyl-3-(N-nitroguanidine))thiourea

Conditions

Conditions	Yield
With potassium hydroxide In N,N-dimethyl-formamide 1.) r.t., 10 min, 2.) r.t., 30 min;	83%
With potassium hydroxide In N,N-dimethyl-formamide
With sodium hydroxide In dimethyl sulfoxide for 1h;
With potassium hydroxide In N,N-dimethyl-formamide at 20℃; for 1.5h;

: 556-88-7
nitroguanidine

: 2284-20-0
4-Methoxyphenyl isothiocyanate

: C9H11N5O3S

Conditions

Conditions	Yield
With potassium hydroxide In N,N-dimethyl-formamide 1.) r.t., 10 min, 2.) r.t., 30 min;	82%
With potassium hydroxide In N,N-dimethyl-formamide at 20℃; for 1.5h;

: 556-88-7
nitroguanidine

: 103-72-0
phenyl isothiocyanate

: 90223-75-9
1-(phenyl-3-(N-nitroguanidine))thiourea

Conditions

Conditions	Yield
With potassium hydroxide In N,N-dimethyl-formamide 1.) r.t., 10 min, 2.) r.t., 30 min;	80%
With potassium hydroxide In N,N-dimethyl-formamide
With sodium hydroxide In dimethyl sulfoxide for 1h;
With potassium hydroxide In N,N-dimethyl-formamide at 20℃; for 1.5h;

: 556-88-7
nitroguanidine

: 74-89-5
methylamine

: 4245-76-5
N-methyl-N'-nitroguanidine

Conditions

Conditions	Yield
In water at 10 - 30℃; for 5h; Temperature; Reagent/catalyst; Sealed tube;	79.58%
at 60 - 70℃;

: 556-88-7
nitroguanidine

: 1-(4-chloro-2-fluorophenyl)propan-2-one

: 1-(4-chloro-2-fluoro-5-nitrophenyl)propan-2-one

Conditions

Conditions	Yield
With sulfuric acid at 0℃; for 2h;	78%

Nitroguanidine Chemical Properties

Product Name: Nitroguanidine (CAS NO.556-88-7):

IUPAC NAME: 2-Nitroguanidine
Molecular Formula: CH₄N₄O₂
Molecular Weight: 104.07 g/mol
CAS No.: 556-88-7
EINECS: 209-143-5
RTECS: MF4600000
RTECS Class: Drug ; Mutagen ; Primary Irritant
Melting Point: 239 °C (dec.)(lit.)
Density: 2 g/cm³
Flash Point: 149.3 °C
Boiling Point: 323.3 °C at 760 mmHg
Product Categories about Nitroguanidine (CAS NO.556-88-7) are Guanidines ; Nitrogen Compounds ; Organic Building Blocks
The chemical synonymous of are Labotest-Bb Ltbb000482 ; [Oxido(oxo)hydrazono]methanediamine ; 1-Nitro-guanidin ; Nitroguanidine ; 2-Nitroguanidine ; Alpha-nitroguanidine ; Beta-nitroguanidine ; Guanidine, 1-nitro-

Nitroguanidine Uses

Nitroguanidine (CAS NO.556-88-7) is used for the preparation of explosives.

Nitroguanidine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	oral	3120mg/kg (3120mg/kg)	LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(1), Pg. 18, 1980.
mouse	LD50	intraperitoneal	48mg/kg (48mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Pharmaceutical Chemistry Journal Vol. 10, Pg. 1504, 1976.
mouse	LD50	oral	3850mg/kg (3850mg/kg)	LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(1), Pg. 18, 1980.
rabbit	LD	skin	> 2gm/kg (2000mg/kg)		National Technical Information Service. Vol. AD-A191-796,
rat	LD50	oral	10200mg/kg (10200mg/kg)	LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(1), Pg. 18, 1980.

Nitroguanidine Consensus Reports

Reported in EPA TSCA Inventory.

Nitroguanidine Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. Mutation data reported. A very dangerous fire hazard when exposed to heat, flame, or by chemical reaction with oxidizers. A severe explosion hazard when shocked or exposed to heat or flame. It is about as powerful as TNT. It is normally mixed with colloided nitrocellulose or ammonium nitrate and paraffin wax. Can react vigorously with oxidizing materials and the derivatives can be explosive. The mercury and silver salts and other derivatives are much more impact-sensitive. When heated to decomposition it emits highly toxic fumes of NO_x. See also NITRO COMPOUNDS.
Hazard Codes:
F: Flammable
Xi: Irritant
Risk Statements about Nitroguanidine (CAS NO.556-88-7):
R5 Heating may cause an explosion.
R11 Highly flammable.
R36/37/38 Irritating to eyes, respiratory system and skin.
Safety Statements about α-Nitroguanidine (CAS NO.556-88-7):
S16 Keep away from sources of ignition - No smoking.
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39 Wear suitable gloves and eye/face protection.
S47 Keep at temperature not exceeding ...°C (to be specified by the manufacturer).

Nitroguanidine Standards and Recommendations

DOT Classification: EXPLOSIVE 1.1D; Label: EXPLOSIVE 1.1D (UN 0282); DOT Class: 4.1; Label: Flammable Solid (UN 1336)

Nitroguanidine Specification

Attention:
1. Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
2. Handling: Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.

Product Name

Nitroguanidine

Synthetic route

Nitroguanidine Chemical Properties

Nitroguanidine Uses

Nitroguanidine Toxicity Data With Reference

Nitroguanidine Consensus Reports

Nitroguanidine Safety Profile

Nitroguanidine Standards and Recommendations

Nitroguanidine Specification

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