Pentachloropyridine supplier

Name
Pentachloropyridine
EINECS 218-535-5
CAS No. 2176-62-7
Article Data40
CAS DataBase
Density 1.764 g/cm³
Solubility
Melting Point 124 °C
Formula C₅Cl₅N
Boiling Point 282.3 °C at 760 mmHg
Molecular Weight 251.327
Flash Point 151.5 °C
Transport Information
Appearance white to off-white flake
Safety 22-26-36-24/25
Risk Codes 22-36/37/38-42/43
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms Pyridine,pentachloro- (6CI,7CI,8CI,9CI);2,3,4,5,6-Pentachloropyridine;NSC 26286;Pentachloropyridine;Perchloropyridine;
PSA 12.89000
LogP 4.34860

Synthetic route

: 2402-79-1
2,3,5,6-tetrachloropyridine

: 2176-62-7
2,3,4,5,6-pentachloropyridine

Conditions

Conditions	Yield
With sodium hydroxide; hexachloroethane; tetrabutylammomium bromide In dichloromethane at 55℃;	71%
With phosphorus pentachloride

: 72012-23-8
tetrachlo-5-iodoropyridine

A: 14121-36-9
2,3,4,6-Tetrachloropyridine

B: 2176-62-7
2,3,4,5,6-pentachloropyridine

C: octachloro-3,3'-bipyridyl

Conditions

Conditions	Yield
With copper In N,N-dimethyl-formamide at 150℃;	A 3% B n/a C 71%

...Expand

: 23995-94-0
4-Bromo-2,3,5,6-tetrachloropyridine

A: 2402-79-1
2,3,5,6-tetrachloropyridine

B: 14121-36-9
2,3,4,6-Tetrachloropyridine

C: 2176-62-7
2,3,4,5,6-pentachloropyridine

D: 18725-60-5
octachloro-4,4'-bipyridyl

Conditions

Conditions	Yield
With Isopropylbenzene; copper In N,N-dimethyl-formamide at 150℃; for 1h; Further byproducts given;	A 63% B 15% C 16% D 17%

...Expand

: 30332-35-5
tetrachloro-4-iodopyridine

A: 2402-79-1
2,3,5,6-tetrachloropyridine

B: 2176-62-7
2,3,4,5,6-pentachloropyridine

C: 18725-60-5
octachloro-4,4'-bipyridyl

Conditions

Conditions	Yield
With copper In N,N-dimethyl-formamide at 150℃;	A 22% B 4% C 52%

...Expand

: 39873-38-6
bis(2,3,5,6-tetrachloropyridin-4-yl)sulfane

A: 2176-62-7
2,3,4,5,6-pentachloropyridine

B: 63954-14-3
hexachlorodipyrido<5,4-b;3,4-d>thiophen

Conditions

Conditions	Yield
In tetrachloromethane for 24h; Irradiation;	A 6.5% B 44%

: 23995-94-0
4-Bromo-2,3,5,6-tetrachloropyridine

A: 2402-79-1
2,3,5,6-tetrachloropyridine

B: 14121-36-9
2,3,4,6-Tetrachloropyridine

C: 2176-62-7
2,3,4,5,6-pentachloropyridine

D: octachloro-3,4'-bipyridyl

E: 18725-60-5
octachloro-4,4'-bipyridyl

Conditions

Conditions	Yield
With para-xylene; copper In N,N-dimethyl-formamide at 150℃; for 1h; Product distribution; Mechanism; the similar reaction without p-xylene; in presence cumene, benzoyl chloride instead p-xylene; other reagent (CuCl); other polychloroiodoarenes; tetrahalohenopyridylcopper intermediate; evidence against free radical or pyridyne intermediates;	A 42% B 5% C 15% D 4% E 18%

...Expand

: 23995-94-0
4-Bromo-2,3,5,6-tetrachloropyridine

A: 2402-79-1
2,3,5,6-tetrachloropyridine

B: 2176-62-7
2,3,4,5,6-pentachloropyridine

C: octachloro-3,4'-bipyridyl

D: 18725-60-5
octachloro-4,4'-bipyridyl

Conditions

Conditions	Yield
With para-xylene; copper In N,N-dimethyl-formamide at 150℃; for 1h; Further byproducts given;	A 42% B 15% C 4% D 18%
With copper In N,N-dimethyl-formamide at 150℃; for 0.5h;	A 17% B 21% C 8% D 14%
With copper In N,N-dimethyl-formamide at 150℃; for 0.5h; Further byproducts given;	A 10% B 10% C 9% D 8%

...Expand

: 74894-12-5
tetrachloro-4-(2-pyridylthio)pyridine

A: 2176-62-7
2,3,4,5,6-pentachloropyridine

B: 74894-22-7
1,3,4-trichlorodipyrido<2,3-b;3,4-d>thiophen

Conditions

Conditions	Yield
In tetrahydrofuran; ethanol for 6h; Irradiation;	A 39% B 13%

: 56-23-5
tetrachloromethane

: 2402-79-1
2,3,5,6-tetrachloropyridine

A: 2176-62-7
2,3,4,5,6-pentachloropyridine

B: 37665-08-0
4-dichloromethyl-2,3,5,6-tetrachloropyridine

C: 4-trichloromethyl-2,3,5,6-tetrachloropyridine

Conditions

Conditions	Yield
With tetrachloromethane; tetrabutylammomium bromide In sodium hydroxide at 50℃; for 4h;	A n/a B 30% C n/a

...Expand

: 27425-94-1
tetrachloro-4-pyridylcopper

: 98-88-4
benzoyl chloride

A: 2402-79-1
2,3,5,6-tetrachloropyridine

B: 18613-89-3
4-benzoyltetrachloropyridine

C: 2176-62-7
2,3,4,5,6-pentachloropyridine

D: 18725-60-5
octachloro-4,4'-bipyridyl

Conditions

Conditions	Yield
With para-xylene In N,N-dimethyl-formamide for 23h; Product distribution; Mechanism; Heating; the similar reaction without p-xylene; other reaction times; similar range of products to those obtained from 4-bromotetrachloropyridine;	A 12% B 13% C 1% D 2.5%

...Expand

: 27425-94-1
tetrachloro-4-pyridylcopper

A: 2402-79-1
2,3,5,6-tetrachloropyridine

B: 18613-89-3
4-benzoyltetrachloropyridine

C: 2176-62-7
2,3,4,5,6-pentachloropyridine

D: 18725-60-5
octachloro-4,4'-bipyridyl

Conditions

Conditions	Yield
With para-xylene; benzoyl chloride In N,N-dimethyl-formamide for 23h; Heating;	A 12% B 13% C 1% D 2.5%

...Expand

: 14092-11-6
1-pyrrolidino-1-cycloheptene

: 17573-93-2
2,3,4,5,6-pentachloropyridine N-oxide

A: 71602-56-7
1-(tetrachloro-2-pyridyl)cyclohexene

B: 2176-62-7
2,3,4,5,6-pentachloropyridine

C: 76277-93-5
2-chloro-7-(tetrachloro-2-pyridyl)cycloheptanone

Conditions

Conditions	Yield
In toluene for 14h; Heating; Yields of byproduct given;	A 11% B n/a C n/a
In toluene for 14h; Heating; Yields of byproduct given;	A n/a B n/a C 5%

...Expand

: 936-52-7
1-(N-morpholino)cyclopent-1-ene

: 17573-93-2
2,3,4,5,6-pentachloropyridine N-oxide

A: 71602-52-3
2-(tetrachloro-N-oxido-2-pyridyl)cyclopentanone

B: 2176-62-7
2,3,4,5,6-pentachloropyridine

Conditions

Conditions	Yield
In toluene for 14h; Heating;	A 6% B 1%

...Expand

: 110-86-1
pyridine

: 2176-62-7
2,3,4,5,6-pentachloropyridine

Conditions

Conditions	Yield
With phosphorus pentachloride
With chlorine

: 2530-26-9
3-nitropyridine

: 2176-62-7
2,3,4,5,6-pentachloropyridine

Conditions

Conditions	Yield
With chlorine at 130 - 150℃;

: 628-13-7
pyridine hydrochloride

: 2176-62-7
2,3,4,5,6-pentachloropyridine

Conditions

Conditions	Yield
With chlorine at 115 - 120℃;

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 2176-62-7
2,3,4,5,6-pentachloropyridine

Conditions

Conditions	Yield
With phosphorus pentachloride

: 100-70-9
2-Cyanopyridine

A: 2176-62-7
2,3,4,5,6-pentachloropyridine

B: 33252-29-8
6-chloro-pyridine-2-carbonitrile

C: 17824-83-8
3,4,5,6-tetrachloropicolinonitrile

D: 139485-42-0
3,4,5-trichloro-2-picolinonitrile

Conditions

Conditions	Yield
With chlorine In tetrachloromethane at 630℃; for 0.00138889h; Product distribution; var. contact times, temperatures, and solvent systems;	A 6.1 % Chromat. B 2.0 % Chromat. C 75.4 % Chromat. D 7.7 % Chromat.

...Expand

: 1134-04-9
2,3,4,5-tetrachloro-6-(trichloromethyl)-pyridine

A: 56-23-5
tetrachloromethane

B: 2176-62-7
2,3,4,5,6-pentachloropyridine

Conditions

Conditions	Yield
With chlorine at 200℃; Rate constant;

: 2402-79-1
2,3,5,6-tetrachloropyridine

: 10026-13-8, 874483-75-7
phosphorus pentachloride

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

(excess) phosphorus pentachloride: (excess) phosphorus pentachloride

: 2176-62-7
2,3,4,5,6-pentachloropyridine

Conditions

Conditions	Yield
at 300℃; im Rohr;

: 694-59-7
pyridine N-oxide

: 7647-01-0
hydrogenchloride

: 7791-25-5
sulfuryl dichloride

A: 109-09-1
2-chloropyridine

B: 626-61-9
4-Chloropyridine

C: 2176-62-7
2,3,4,5,6-pentachloropyridine

Conditions

Conditions	Yield
at 120℃;

...Expand

: 110-86-1
pyridine

: 7782-50-5
chlorine

A: 626-60-8
3-Chloropyridine

B: 33216-52-3
3,4,5-trichloropyridine

C: 2176-62-7
2,3,4,5,6-pentachloropyridine

D: 2457-47-8
3,5-dichloropyridine

Conditions

Conditions	Yield
at 170℃; beim Behandeln des Pyridin-hydrochlorids;

...Expand

: 1201-30-5
3,4,5-trichloro-2-trichloromethyl pyridine

A: 56-23-5
tetrachloromethane

B: 2808-86-8
2,3,4,5-tetrachloro-pyridine

C: 2176-62-7
2,3,4,5,6-pentachloropyridine

D: 1134-04-9
2,3,4,5-tetrachloro-6-(trichloromethyl)-pyridine

E HCl: HCl

Conditions

Conditions	Yield
With chlorine at 200℃; for 18h; Title compound not separated from byproducts;	A n/a B 9.7 % Chromat. C 3.2 % Chromat. D 11.8 % Chromat. E n/a
With chlorine at 200℃; for 18h; Irradiation; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With chlorine at 245℃; Thermodynamic data; Kinetics; Rate constant; other temperature, irrradiation, activation energies;
With chlorine at 200℃; for 18h; Product distribution; other time;	A n/a B 9.7 % Chromat. C 3.2 % Chromat. D 11.8 % Chromat. E n/a

...Expand

carbon: carbon

A: 2176-62-7
2,3,4,5,6-pentachloropyridine

B: 67-72-1
hexachloroethane

C: 118-74-1
hexachlorobenzene

D: 29082-74-4
octachlorostyrene

Conditions

Conditions	Yield
With aluminium trichloride at 300℃; for 24h; Chlorination; cyclization; Further byproducts given. Title compound not separated from byproducts;

...Expand

anode graphite: anode graphite

A: 2176-62-7
2,3,4,5,6-pentachloropyridine

B: 87-68-3
Hexachlorobutadiene

C: 118-74-1
hexachlorobenzene

D: 29082-74-4
octachlorostyrene

Conditions

Conditions	Yield
With melt electrolyte at 700℃; Formation of xenobiotics; electrolysis; Further byproducts given. Title compound not separated from byproducts;

...Expand

graphite: graphite

: 2176-62-7
2,3,4,5,6-pentachloropyridine

Conditions

Conditions	Yield
With oxygen; urea; copper dichloride at 300℃; Formation of xenobiotics;

: 16063-70-0
2,3,5-trichloropyridine

: 2176-62-7
2,3,4,5,6-pentachloropyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: C2Cl6; nBu4NBr; aq. NaOH / 4 h / 50 °C 2: 71 percent / C2Cl6; nBu4NBr; aq. NaOH / CH2Cl2 / 55 °C View Scheme

: 23995-94-0
4-Bromo-2,3,5,6-tetrachloropyridine

: 2176-62-7
2,3,4,5,6-pentachloropyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 39 percent / potassium carbonate / acetone / 2 h / Heating 2: 39 percent / tetrahydrofuran; ethanol / 6 h / Irradiation View Scheme

: 1122-58-3
dmap

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: 1-(4-dimethylamino)-[2,3,5,6-tetrachloro-pyridin-4-yl]pyridinium chloride

Conditions

Conditions	Yield
In 1,2-dichloro-benzene at 80℃; for 3h;	100%
In 1,2-dichloro-benzene at 60℃;	87%
In 1,2-dichloro-benzene at 80 - 90℃;

: 1122-58-3
dmap

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: (3,5-dichloropyridine-2,4,6-triyl)-1,1',1''-tris[4-(dimethylamino)pyridinium] trichloride

Conditions

Conditions	Yield
In 1,2-dichloro-benzene at 120℃; for 3h;	100%
In 1,2-dichloro-benzene Heating;
Heating;

: 504-24-5
4-aminopyridine

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: 1,1',1''-tris[4-amino-(3,5-dichloropyridine-2,4,6-triyl)-pyridinium] trichloride

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 120℃; for 1h;	100%
Heating;

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: 2456-81-7
4-pyrrolidin-1-ylpyridine

: 1,1',1''-tris[4-pyrrolidino-(3,5-dichloropyridine-2,4,6-triyl)-pyridinium] trichloride

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 120℃; for 2h;	100%

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: 2402-79-1
2,3,5,6-tetrachloropyridine

Conditions

Conditions	Yield
Stage #1: 2,3,4,5,6-pentachloropyridine With manganese; ammonium acetate In ethanol; water at 40℃; for 6h; Stage #2: With ammonia In ethanol; water at 65℃; for 1h; pH=8 - 9; Concentration; Temperature;	99.5%
With ammonium chloride; zinc In acetonitrile at 80℃; for 3h; Reagent/catalyst; Solvent; Temperature; Green chemistry;	88.4%
With ammonium chloride; dimethyl methane phosphonate; zinc In water for 0.5h; Yield given;

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: 1795-31-9
tris(trimethylsilyl) phosphite

: C11H18Cl4NO3PSi2

Conditions

Conditions	Yield
With nickel dichloride at 150℃; for 0.5h;	99%

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: 98-80-6
phenylboronic acid

: 40249-26-1
2,3,4,5,6-pentaphenylpyridine

Conditions

Conditions	Yield
With dichloro bis(acetonitrile) palladium(II); potassium phosphate; 2-dicyclohexylphosphino-2’,6’-dimethoxybiphenyl In toluene at 100℃; for 20h; Catalytic behavior; Solvent; Reagent/catalyst; Temperature; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique; Sealed tube;	99%
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro bis(acetonitrile) palladium(II)	99%

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: 5720-05-8
4-methylphenylboronic acid

: 1639431-10-9
2,3,4,5,6-pentakis(4-tolyl)pyridine

Conditions

Conditions	Yield
With dichloro bis(acetonitrile) palladium(II); potassium phosphate; 2-dicyclohexylphosphino-2’,6’-dimethoxybiphenyl In toluene at 100℃; for 20h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique; Sealed tube;	99%

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: 5720-07-0
4-methoxyphenylboronic acid

: 1639431-14-3
2,3,4,5,6-pentakis(4-methoxyphenyl)pyridine

Conditions

Conditions	Yield
With dichloro bis(acetonitrile) palladium(II); potassium phosphate; 2-dicyclohexylphosphino-2’,6’-dimethoxybiphenyl In toluene at 100℃; for 20h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique; Sealed tube;	99%

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: 51379-64-7
2,3,5,6-tetrachloro-4-azidopyridine

Conditions

Conditions	Yield
With sodium azide In acetone at 20℃;	98%

: 2176-62-7
2,3,4,5,6-pentachloropyridine

A: 6515-09-9
2,3,6-trichloropyridine

B: 16063-70-0
2,3,5-trichloropyridine

C: 2402-79-1
2,3,5,6-tetrachloropyridine

Conditions

Conditions	Yield
With ammonium chloride; dimethyl methane phosphonate; zinc In water at 85 - 90℃; Product distribution; other ammonium salts; other methylphosphonates/phosphates;	A 0.9% B 1% C 97.6%

...Expand

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: 5188-07-8
sodium thiomethoxide

: 22963-62-8
2,3,5,6-tetrachloro-4-methylmercaptopyridine

Conditions

Conditions	Yield
With sodium iodide In methanol; water at 20℃; for 4h; Solvent; Reagent/catalyst; Cooling with ice;	96%
In tetrahydrofuran; water at 20℃; for 1h; Temperature; Large scale;

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: 1737-93-5
3,5-dichloro-2,4,6-trifluoropyridine

Conditions

Conditions	Yield
With potassium fluoride at 90℃; for 1.5h; Temperature; Reagent/catalyst; Concentration;	95.42%
With hydrogen fluoride; tetramethylammonium fluoride In water; isopropyl alcohol at -10 - 135℃; Temperature; Flow reactor; Green chemistry;	94.7%
With potassium fluoride In sulfolane at 190℃; for 72h;	93%

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: 2456-81-7
4-pyrrolidin-1-ylpyridine

: 1-(4-pyrrolidino)-[2,3,5,6-tetrachloropyridin-4-yl]-pyridinium chloride

Conditions

Conditions	Yield
In 1,2-dichloro-benzene at 20℃; for 24h;	95%

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: 51379-63-6
3,5-dichloro-2,4,6-triazido-pyridine

Conditions

Conditions	Yield
With sodium azide In water; acetone at 70℃; for 72h; azidation;	94%
With sodium azide In acetone at 70℃; for 72h;	84%

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: 536-74-3
phenylacetylene

: 1269423-16-6
2,3,4,5,6-pentakis(phenylethynyl)pyridine

Conditions

Conditions	Yield
With dichloro bis(acetonitrile) palladium(II); copper(l) iodide; diisopropylamine; XPhos In 1,4-dioxane at 80℃; for 10h; Sonogashira coupling; Inert atmosphere; Sealed tube;	92%

: 2176-62-7
2,3,4,5,6-pentachloropyridine

A: 2322-38-5
2,3,5,6-tetrachloro-4-pyridinol

B: 17368-22-8
3,4,5,6-tetrachloro-2-pyridinol

Conditions

Conditions	Yield
With potassium hydroxide In tert-butyl alcohol for 10h; Heating;	A n/a B 90%

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: 2617-79-0
N-(4-chlorophenyl)formamide

: 33028-83-0
2,3,5,6-tetrachloro-N-(4-chlorophenyl)pyridin-4-amine

Conditions

Conditions	Yield
Stage #1: N-(4-chlorophenyl)formamide With potassium carbonate In acetonitrile for 0.5h; Reflux; Stage #2: 2,3,4,5,6-pentachloropyridine In acetonitrile at 85℃; for 12h; Solvent; Temperature;	90%

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: 1141931-76-1
1,3,4-trichloro-9-(4-methylbenzylidene)-6-(p-tolyl)-6,7,8,9-tetrahydrocyclopenta[D]pyrido[4′,3′:4,5]thiazolo[3,2-a]pyrimidine

: C27H20Cl3N3S

Conditions

Conditions	Yield
Stage #1: 1,3,4-trichloro-9-(4-methylbenzylidene)-6-(p-tolyl)-6,7,8,9-tetrahydrocyclopenta[D]pyrido[4′,3′:4,5]thiazolo[3,2-a]pyrimidine With potassium carbonate In acetonitrile at 100 - 110℃; for 0.5h; Stage #2: 2,3,4,5,6-pentachloropyridine In acetonitrile for 24h; Solvent; Reflux;	90%

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: 128-04-1
sodium dimethyldithiocarbamate

: 2,3,5,6-tetrachloro-4-pyridyl N,N-dimethyldithiocarbamate

Conditions

Conditions	Yield
In acetone for 5h; Heating;	89%
In acetone	89%

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: 772-38-3
4-tert-Butylphenylacetylene

: 1269423-18-8
2,3,4,5,6-pentakis(4-tert-butylphenylethynyl)pyridine

Conditions

Conditions	Yield
With dichloro bis(acetonitrile) palladium(II); copper(l) iodide; diisopropylamine; XPhos In 1,4-dioxane at 80℃; for 10h; Sonogashira coupling; Inert atmosphere; Sealed tube;	89%

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: 123324-71-0
4-tert-butylphenylboronic acid

: 1639431-13-2
2,3,4,5,6-pentakis(4-tert-butylphenyl)pyridine

Conditions

Conditions	Yield
With dichloro bis(acetonitrile) palladium(II); potassium phosphate; 2-dicyclohexylphosphino-2’,6’-dimethoxybiphenyl In toluene at 100℃; for 20h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique; Sealed tube;	89%

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: 139301-27-2
4-trifluoromethoxyphenylboronic acid

: 1639431-20-1
2,3,4,5,6-pentakis[4-(trifluoromethoxy)phenyl]pyridine

Conditions

Conditions	Yield
With dichloro bis(acetonitrile) palladium(II); potassium phosphate; 2-dicyclohexylphosphino-2’,6’-dimethoxybiphenyl In toluene at 100℃; for 20h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique; Sealed tube;	89%

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: 65331-29-5
8-(4-methylbenzylidene)-3,4,5,6,7,8-hexahydro-4-(4-methylphenyl)quinazoline-2(1H)-thione

: C28H22Cl3N3S

Conditions

Conditions	Yield
Stage #1: 8-(4-methylbenzylidene)-3,4,5,6,7,8-hexahydro-4-(4-methylphenyl)quinazoline-2(1H)-thione With potassium carbonate In acetonitrile at 100 - 110℃; for 0.5h; Stage #2: 2,3,4,5,6-pentachloropyridine In acetonitrile for 22h; Reflux;	89%

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: C24H26N2O4S

: C29H24Cl3N3O4S

Conditions

Conditions	Yield
Stage #1: C24H26N2O4S With potassium carbonate In acetonitrile at 100 - 110℃; for 0.5h; Stage #2: 2,3,4,5,6-pentachloropyridine In acetonitrile for 25h; Reflux;	89%

: 766-98-3
1-ethynyl-4-fluorobenzene

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: 1269423-19-9
2,3,4,5,6-pentakis(4-fluorophenylethynyl)pyridine

Conditions

Conditions	Yield
With dichloro bis(acetonitrile) palladium(II); copper(l) iodide; diisopropylamine; XPhos In 1,4-dioxane at 80℃; for 8h; Sonogashira coupling; Inert atmosphere; Sealed tube;	88%

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: 131652-00-1
7-(4-methoxybenzylidene)-4-(4-methoxyphenyl)-3, 4, 6,7-tetrahydro-1H cyclopenta[d]pyrimidin-2(5H)-thione

: C27H20Cl3N3O2S

Conditions

Conditions	Yield
Stage #1: 7-(4-methoxybenzylidene)-4-(4-methoxyphenyl)-3, 4, 6,7-tetrahydro-1H cyclopenta[d]pyrimidin-2(5H)-thione With potassium carbonate In acetonitrile at 100 - 110℃; for 0.5h; Stage #2: 2,3,4,5,6-pentachloropyridine In acetonitrile for 26h; Reflux;	88%

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: N-Fluoropentachloropyridinium tetrafluoroborate

Conditions

Conditions	Yield
With boron trifluoride; fluorine In trifluoroacetic acid at 10℃; for 3h;	87%

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: 52207-49-5
potassium S-i-propyltrithiocarbonate

: 19050-46-5
2,3,5,6-tetrachloro-4-(isopropylsulfanyl)pyridine

Conditions

Conditions	Yield
In ethanol at 20℃; for 6h; Substitution;	87%

: 2176-62-7
2,3,4,5,6-pentachloropyridine

: 65331-30-8
8-(4-methoxybenzylidene)-3,4,5,6,7,8-hexahydro-4-(4-methoxyphenyl)quinazoline-2(1H)-thione

: C28H22Cl3N3O2S

Conditions

Conditions	Yield
Stage #1: 8-(4-methoxybenzylidene)-3,4,5,6,7,8-hexahydro-4-(4-methoxyphenyl)quinazoline-2(1H)-thione With potassium carbonate In acetonitrile at 100 - 110℃; for 0.5h; Stage #2: 2,3,4,5,6-pentachloropyridine In acetonitrile for 23h; Reflux;	87%

Pentachloropyridine Consensus Reports

Reported in EPA TSCA Inventory.

Pentachloropyridine Specification

The Pentachloropyridine is an organic compound with the formula C₅Cl₅N. The IUPAC name of this chemical is 2,3,4,5,6-pentachloropyridine. With the CAS registry number 2176-62-7, it is also named as pyridine, 2,3,4,5,6-pentachloro-. The product's categories are Chloropyridines; Halopyridines; C5Heterocyclic Building Blocks; Halogenated Heterocycles; Heterocyclic Building Blocks; Pyridines. Besides, it is white to off-white flake, which should be stored in a closed cool and dry place. It is used as a pesticide and pharmaceutical intermediates, which can be used for production pesticides of chlorpyrifos and dichloro-pyridine acid.

Physical properties about Pentachloropyridine are: (1)ACD/LogP: 3.61; (2)ACD/LogD (pH 5.5): 3.61; (3)ACD/LogD (pH 7.4): 3.61; (4)ACD/BCF (pH 5.5): 323.72; (5)ACD/BCF (pH 7.4): 323.72; (6)ACD/KOC (pH 5.5): 2179.63; (7)ACD/KOC (pH 7.4): 2179.63; (8)#H bond acceptors: 1; (9)Polar Surface Area: 12.89 Å²; (10)Index of Refraction: 1.601; (11)Molar Refractivity: 48.81 cm³; (12)Molar Volume: 142.4 cm³; (13)Polarizability: 19.35×10^-24cm³; (14)Surface Tension: 51.1 dyne/cm; (15)Density: 1.764 g/cm³; (16)Flash Point: 151.5 °C; (17)Enthalpy of Vaporization: 50.02 kJ/mol; (18)Boiling Point: 282.3 °C at 760 mmHg; (19)Vapour Pressure: 0.00579 mmHg at 25°C.

Preparation: this chemical can be prepared by octachloro-4,4'-sulfanediyl-bis-pyridine. This reaction will need reagent CCl₄. The reaction time is 22 hours. The yield is about 44%.

Uses of Pentachloropyridine: it can be used to produce 3,5-dichloro-2,4,6-trifluoro-pyridine at temperature of 190 °C. It will need reagent KF and solvent tetrahydrothiophene 1,1-dioxide with reaction time of 3 days. The yield is about 93%.

When you are using this chemical, please be cautious about it as the following:
It is harmful if swallowed and may cause sensitisation by inhalation and skin contact. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable protective clothing, do not breathe dust and avoid contact with skin and eyes.

You can still convert the following datas into molecular structure:
(1)SMILES: Clc1c(Cl)c(Cl)nc(Cl)c1Cl
(2)InChI: InChI=1/C5Cl5N/c6-1-2(7)4(9)11-5(10)3(1)8
(3)InChIKey: DNDPLEAVNVOOQZ-UHFFFAOYAW
(4)Std. InChI: InChI=1S/C5Cl5N/c6-1-2(7)4(9)11-5(10)3(1)8
(5)Std. InChIKey: DNDPLEAVNVOOQZ-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	235mg/kg (235mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ANTIPSYCHOTIC LIVER: FATTY LIVER DEGERATION	Toxicology and Applied Pharmacology. Vol. 11, Pg. 361, 1967.
rat	LD50	oral	435mg/kg (435mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	National Technical Information Service. Vol. OTS0536503,

Product Name

Pentachloropyridine

Synthetic route

Pentachloropyridine Consensus Reports

Pentachloropyridine Specification

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