Phenyl bromoacetate supplier

Name
Phenyl bromoacetate
EINECS 805-881-2
CAS No. 620-72-4
Article Data32
CAS DataBase
Density 1.533 g/cm³
Solubility Soluble in ethanol and ether, insoluble in water.
Melting Point 31-33 °C(lit.)
Formula C₈H₇BrO₂
Boiling Point 261.9 °C at 760 mmHg
Molecular Weight 215.046
Flash Point 112.2 °C
Transport Information
Appearance Liquid
Safety 24/25
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Aceticacid, bromo-, phenyl ester (6CI,7CI,8CI,9CI);alpha-Phenyl Bromoacetate;Phenyl a-bromoacetate;bromoacetic acidphenyl ester;
PSA 26.30000
LogP 1.98690

Synthetic route

: 598-21-0
2-Bromoacetyl bromide

: 108-95-2
phenol

: 620-72-4
phenyl 2-bromoacetate

Conditions

Conditions	Yield
Heating;	92%
With triethylamine In dichloromethane at 0℃; for 1.5h; Inert atmosphere;	81%
at 80℃; for 1h;	77%

: 100-66-3
methoxybenzene

: 598-21-0
2-Bromoacetyl bromide

: 620-72-4
phenyl 2-bromoacetate

Conditions

Conditions	Yield
With zinc(II) chloride at 50 - 70℃; for 3.5h;	38%

: 79-08-3
bromoacetic acid

: 108-95-2
phenol

: 620-72-4
phenyl 2-bromoacetate

Conditions

Conditions	Yield
(i) DCC, THF, (ii) /BRN= 506167/; Multistep reaction;
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃;

<β.β-dibromo-vinyl>-phenyl ether: <β.β-dibromo-vinyl>-phenyl ether

: 620-72-4
phenyl 2-bromoacetate

Conditions

Conditions	Yield
With acetic acid at 100℃; im geschlossenen Rohr;

bromoacetimidic acid phenyl ester hydrochloride: bromoacetimidic acid phenyl ester hydrochloride

: 620-72-4
phenyl 2-bromoacetate

Conditions

Conditions	Yield
With water

: 7647-01-0
hydrogenchloride

: 60-29-7
diethyl ether

: bromoethynyl-phenyl ether

: 1600-27-7
mercury(II) diacetate

: 620-72-4
phenyl 2-bromoacetate

Conditions

Conditions	Yield
at 10℃;

...Expand

: 7732-18-5
water

: 2-bromo-acetimidic acid phenyl ester; hydrochloride

: 620-72-4
phenyl 2-bromoacetate

: 106-41-2
4-bromo-phenol

: 620-72-4
phenyl 2-bromoacetate

Conditions

Conditions	Yield
With sulfuric acid In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; acetic anhydride

: 620-72-4
phenyl 2-bromoacetate

: 74802-29-2
3S-3-<<(1,1-Dimethylethoxy)carbonyl>amino>-2,5-dioxo-2,3,4,5-tetrahydro-1H-1-benzazepine

: 128776-36-3
Benzyl 2-(3S-3-<<(1,1-Dimethylethoxy)carbonyl>amino>-2,5-dioxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)-ethanoate

Conditions

Conditions	Yield
With tetrabutylammomium bromide; potassium carbonate In acetone	98%

: 620-72-4
phenyl 2-bromoacetate

: 603-35-0
triphenylphosphine

: 32443-55-3
((triphenyl)-λ5-phosphanylidene)acetic acid phenyl ester

Conditions

Conditions	Yield
Stage #1: phenyl 2-bromoacetate; triphenylphosphine In chloroform at 23℃; Inert atmosphere; Stage #2: With sodium hydroxide In water	96%
Stage #1: phenyl 2-bromoacetate; triphenylphosphine In benzene at 20℃; for 18h; Stage #2: With sodium hydroxide In dichloromethane; water for 0.5h;
Multi-step reaction with 2 steps 1: toluene / 12 h / Inert atmosphere 2: sodium hydroxide / dichloromethane; water / 0.33 h / 20 °C View Scheme

: 620-72-4
phenyl 2-bromoacetate

: 244126-36-1
(1R,9S,10R,11R,12R)-12-Amino-6-bromo-3,4-dimethoxy-5-methyl-13-(toluene-4-sulfonyl)-13-aza-tricyclo[7.3.1.02,7]trideca-2(7),3,5-triene-10,11-diol

: C24H27BrN2O7S

Conditions

Conditions	Yield
With 4 A molecular sieve; methyloxirane In acetonitrile at 80℃; Cyclization;	92%

: 620-72-4
phenyl 2-bromoacetate

: 1533519-84-4
4-(4-cyclopropylnaphthalen-1-yl)-4Η-1,2,4-triazole-3-thiol

: phenyl 2‐((4‐(4‐cyclopropylnaphthalen‐1‐yl)‐4H‐1,2,4‐triazol‐3‐yl)thio)acetate

Conditions

Conditions	Yield
Stage #1: 4-(4-cyclopropylnaphthalen-1-yl)-4Η-1,2,4-triazole-3-thiol With triethylamine In isopropyl alcohol at 20℃; for 0.333333h; Stage #2: phenyl 2-bromoacetate In isopropyl alcohol at 0 - 20℃; for 2h;	92%

: 620-72-4
phenyl 2-bromoacetate

: sodium salt of 2-nitroimidazole

: 165062-75-9
(2-Nitro-imidazol-1-yl)-acetic acid phenyl ester

Conditions

Conditions	Yield
With 15-crown-5 In acetonitrile for 3h; Ambient temperature;	91%

: (S)-2-amino-3-((tert-butyldiphenylsilyl)oxy)propan-1-ol

: 620-72-4
phenyl 2-bromoacetate

: C21H27NO3Si

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 4h;	91%

: 620-72-4
phenyl 2-bromoacetate

: 1414948-65-4
(1R,3S)-2-chloroethyl 1-[(R)-1-amino-2-hydroxyethyl]-8-benzyloxy-3-(dimethoxymethyl)-7-methoxy-6-methyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1414948-69-8
(1R,3S)-2-chloroethyl 8-(benzyloxy)-3-(dimethoxymethyl)-7-methoxy-6-methyl-1-[(R)-6-oxomorpholin-3-yl]-3,4-dihydroisoquinoline-2(1H)-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 0 - 20℃; for 23.5h;	91%

: 620-72-4
phenyl 2-bromoacetate

: C10H13N3O3S

: C12H13N3O4S

Conditions

Conditions	Yield
With sulfuric acid; sodium acetate In acetonitrile for 0.333333h; Reflux;	91%

: 874758-59-5
(1R,3S)-3-Acetoxymethyl-8-allyloxy-1-((R)-1-amino-2-hydroxy-ethyl)-7-methoxy-6-methyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid allyl ester

: 620-72-4
phenyl 2-bromoacetate

: C25H32N2O8

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 10℃; for 4h;	90%

: 620-72-4
phenyl 2-bromoacetate

: 1-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)ethan-1-one N-ethyl thiosemicarbazone

: C13H15N3O4S

Conditions

Conditions	Yield
With sulfuric acid; sodium acetate In acetonitrile for 0.166667h; Reflux;	90%

: 620-72-4
phenyl 2-bromoacetate

: 305837-95-0
4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide

: phenyl N-(3-phenylprop-2-yn-1-yl)-N-tosylglycinate

Conditions

Conditions	Yield
With potassium carbonate In acetone at 20℃; for 16h;	90%

: 620-72-4
phenyl 2-bromoacetate

: 75843-20-8
3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one thiosemicarbazone

: C11H11N3O4S

Conditions

Conditions	Yield
With sulfuric acid; sodium acetate In acetonitrile for 0.333333h; Reflux;	88%

: 620-72-4
phenyl 2-bromoacetate

: 110480-87-0
(R)-1-amino-2-methyl-1-phenyl-propan-2-ol

: ((R)-2-Hydroxy-2-methyl-1-phenyl-propylamino)-acetic acid phenyl ester

Conditions

Conditions	Yield
With methyloxirane In acetonitrile at 50℃;	81%

: 24424-99-5
di-tert-butyl dicarbonate

: 620-72-4
phenyl 2-bromoacetate

: 883442-71-5
tert-butyl (5R)-5-[(1S,2S)-1-benzyloxy-3-(3,5-difluorophenyl)-2-methylpropyl]-2-oxomorpholine-4-carboxylate

Conditions

Conditions	Yield
Stage #1: (2R,3R,4S)-2-amino-3-benzyloxy-4-dibenzylamino-5-(3,5-difluorophenyl)-pentan-1-ol; phenyl 2-bromoacetate With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 14h; Stage #2: di-tert-butyl dicarbonate In N,N-dimethyl-formamide at 20℃; for 20h;	81%

: 620-72-4
phenyl 2-bromoacetate

: 56613-80-0
(R)-Phenylglycinol

: 121269-45-2
(R)-5-phenyl-3,4,5,6-tetrahydro-2H-1,4-oxazin-2-one

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 18h; Ambient temperature;	78%
With N-ethyl-N,N-diisopropylamine In acetonitrile	24%
With N-ethyl-N,N-diisopropylamine In acetonitrile

: 620-72-4
phenyl 2-bromoacetate

: 2-(1-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)ethylidene)-N-phenylhydrazinecarbothioamide

: C17H15N3O4S

Conditions

Conditions	Yield
With sulfuric acid; sodium acetate In acetonitrile for 0.333333h; Reflux;	78%

: 620-72-4
phenyl 2-bromoacetate

: 1444623-25-9
diethyl 2-allyl-2-(4-methoxyphenethyl)malonate

: 563-63-3
silver(I) acetate

: C29H36O9

Conditions

Conditions	Yield
With tris[2-phenylpyridinato-C2,N]iridium(III) In dichloromethane at 25℃; Irradiation;	78%

...Expand

: 620-72-4
phenyl 2-bromoacetate

: (Rp)-13-iodo-1,4(1,4)-dibenzenacyclohexaphan-12-ol

: phenyl (Rp)-2-[(13-iodo-1,4(1,4)-dibenzenacyclohexaphane-12-yl)oxy]acetate

Conditions

Conditions	Yield
With potassium carbonate In acetone at 0 - 20℃; for 10h;	77%

: 620-72-4
phenyl 2-bromoacetate

: 346621-58-7
dimethyl 2-(3-phenylprop-2-yn-1-yl)malonate

: 2,2-dimethyl 1-phenyl 5-phenylpent-4-yne-1,2,2-tricarboxylate

Conditions

Conditions	Yield
Stage #1: dimethyl 2-(3-phenylprop-2-yn-1-yl)malonate With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 0.75h; Cooling with ice; Stage #2: phenyl 2-bromoacetate In tetrahydrofuran; mineral oil at 0℃; for 2.5h;	76%

: 620-72-4
phenyl 2-bromoacetate

: 20989-17-7
(2S)-2-phenylglycinol

: 144896-92-4
(5S)-5-phenylmorpholin-2-one

Conditions

Conditions	Yield
	75%
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 24h;	70%
With N-ethyl-N,N-diisopropylamine In acetonitrile Inert atmosphere;	53%
With N-ethyl-N,N-diisopropylamine In acetonitrile at -5 - 20℃; for 20.5h; Inert atmosphere;	53%
Stage #1: (2S)-2-phenylglycinol With N-ethyl-N,N-diisopropylamine In acetonitrile Stage #2: phenyl 2-bromoacetate In acetonitrile at 20℃; for 3.75h;

: 620-72-4
phenyl 2-bromoacetate

: 110480-86-9
(1S)-1-amino-2-methyl-1-phenylpropan-2-ol

: 723262-92-8
(S)-6,6-dimethyl-5-phenylmorpholin-2-one

Conditions

Conditions	Yield
Stage #1: phenyl 2-bromoacetate; (1S)-1-amino-2-methyl-1-phenylpropan-2-ol With methyloxirane In acetonitrile at 80℃; for 4h; Stage #2: In toluene for 15h; Heating;	75%

: 620-72-4
phenyl 2-bromoacetate

: 71335-68-7
4-(N,N-dimethylamino)-2,2,6,6-tetramethylpiperidin-1-oxyl

: 1051372-91-8
Br(1-)*C19H30N2O3(1+)

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 8h;	75%

: 530-48-3
1,1-Diphenylethylene

: 620-72-4
phenyl 2-bromoacetate

: 7746-94-3
5,5-diphenyldihydrofuran-2(3H)-one

Conditions

Conditions	Yield
With lithium tetrafluoroborate; fac-tris[2-phenylpyridinato-C2,N]iridium(III) In water; acetonitrile at 20℃; for 24h; Mechanism; Inert atmosphere; Irradiation; regioselective reaction;	75%

: 110-86-1
pyridine

: 620-72-4
phenyl 2-bromoacetate

: 1-(2-oxo-2-phenoxyethyl)pyridin-1-ium bromide

Conditions

Conditions	Yield
In tetrahydrofuran at 60℃; for 12h; Inert atmosphere;	74.7%

: 620-72-4
phenyl 2-bromoacetate

: 7480-35-5, 13286-59-4, 74165-73-4, 126456-43-7, 136030-00-7, 140632-19-5, 140632-20-8
(1S,2R)-1-amino-2-indanol

: 1428243-82-6
(4aS,9aR)-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-2(3H)-one

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 3h; Inert atmosphere;	72.1%

: 620-72-4
phenyl 2-bromoacetate

: tris-4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyl allyl stannane

: 51231-09-5
phenyl pent-4-enoate

Conditions

Conditions	Yield
With α,α,α-trifluorotoluene at 25℃; Irradiation;	72%

Phenyl bromoacetate Chemical Properties

Product Name: Phenyl bromoacetate (CAS NO.620-72-4)

Molecular Formula: C₈H₇BrO₂
Molecular Weight: 215.04g/mol
Mol File: 620-72-4.mol
Melting Point: 31-33 °C(lit.)
Boiling point: 261.9 °C at 760 mmHg
Flash Point: 112.2 °C
Density: 1.533 g/cm³
Surface Tension: 43.8 dyne/cm
Enthalpy of Vaporization: 49.97 kJ/mol
Vapour Pressure: 0.0112 mmHg at 25°C
Product Categories: C8 to C9; Carbonyl Compounds; Esters

Phenyl bromoacetate Specification

Phenyl bromoacetate , its CAS NO. is 620-72-4, the synonym is alpha-Phenyl Bromoacetate .

Product Name

Phenyl bromoacetate

Synthetic route

Phenyl bromoacetate Chemical Properties

Phenyl bromoacetate Specification

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